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au:MACHADO, CRISTINA MARIA MONTEIRO

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Mirabegron and Anticholinergics in the Treatment of Overactive Bladder Syndrome: A Meta-analysis
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Sartori, Luisa Gracio Ferreira

; Nunes, Bruno Monteiro

; Farah, Daniela

; Oliveira, Leticia Maria de

; Novoa, Claudia Cristina Takano

; Sartori, Marair Gracio Ferreira

; Fonseca, Marcelo Cunio Machado

Revista Brasileira de Ginecologia e Obstetrícia

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jun 2023, Volume 45 N. 6 Pages 337 - 346

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective To compare the use of mirabegron with anticholinergics drugs for the treatment of overactive bladder (OB). Data Source Systematic searches were conducted in EMBASE, PUBMED, Cochrane, and LILACS databases from inception to September 2021. We included RCTs, women with clinically proven OB symptoms, studies that compared mirabegron to antimuscarinic drugs, and that evaluated the efficacy, safety or adherence. Data Collection RevMan 5.4 was used to combine results across studies. We derived risk ratios (RRs) and mean differences with 95% CIs using a random-effects meta-analytic model. Cochrane Collaboration Tool and GRADE was applied for risk of bias and quality of the evidence. Data Synthesis We included 14 studies with a total of 10,774 patients. Fewer total adverse events was reported in mirabegron group than in antimuscarinics group [RR 0.93 (0.89–0.98)]. The risk of gastrointestinal tract disorders and dry mouth were lower with mirabegron [RR 0,58 (0.48–0.68); 9375 patients; RR 0.44 (0.35–0.56), 9375 patients, respectively]. No difference was reported between mirabegron and antimuscarinics drugs for efficacy. The adherence to treatment was 87.7% in both groups [RR 0.99 (0.98–1.00)]. Conclusion Mirabegron and antimuscarinics have comparable efficacy and adherence rates; however, mirabegron showed fewer total and isolated adverse events.

Resumo Objetivo Comparar o uso de mirabegrom com anticolinérgicos para o tratamento da bexiga hiperativa (BH). Fonte de Dados Buscas sistemáticas foram realizadas nas bases de dados EMBASE, PUBMED, Cochrane e LILACS desde o início até setembro de 2021. Incluímos ECR, mulheres com sintomas de BH clinicamente comprovados, estudos que compararam mirabegrom a medicamentos antimuscarínicos e avaliaram a eficácia, segurança ou adesão. Coleta de Dados RevMan 5.4 foi usado para combinar os resultados entre os estudos. Derivamos razões de risco (RRs) e diferenças médias com intervalo de confiança (IC) de 95% usando um modelo meta-analítico de efeitos aleatórios. Cochrane Collaboration Tool e GRADE foi aplicado para risco de viés e qualidade da evidência. Síntese dos Dados Foram incluídos 14 estudos com um total de 10.774 pacientes. Menos eventos adversos totais foram relatados no grupo mirabegrom do que no grupo antimuscarínicos [RR: 0,93 (0,89–0,98)]. O risco de distúrbios do trato gastrointestinal e boca seca foram menores com mirabegrom [RR: 0,58 (0,48–0,68); 9.375 pacientes; RR: 0,44 (0,35–0,56), 9.375 pacientes, respectivamente]. Nenhuma diferença foi relatada entre mirabegrom e drogas antimuscarínicos para eficácia. A adesão ao tratamento foi de 87,7% em ambos os grupos [RR: 0,99 (0,98–1,00)]. Conclusão Mirabegrom e antimuscarínicos têm eficácia e taxas de adesão comparáveis, porém o mirabegrom apresentou menos eventos adversos totais e isolados.

https://doi.org/10.1055/s-0043-1770093

Detection of HPV DNA in vaginal samples self-collected by women living with HIV treated through the Brazilian public health system: Prevalence and analysis of risk factors
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Silveira, Mariângela Freitas da

; Buffarini, Romina

; Gaspar, Pâmela Cristina

; Machado, Hanalydia de Melo

; Bazzo, Maria Luiza

; Scherer, Aline

; Colusso, Álvaro Luis

; Travassos, Ana Gabriela Álvares

; Arakaki-Sanchez, Denise

; Baia-da-Silva, Djane Clarys

; Oliveira, Eduardo Campos de

; Zago, Isabella Ribeiro

; Moura, Marcos de Assis

; Lacerda, Marcus Vinicius Guimarães de

; Martins, Simone Murta

; Reuter, Tânia

; Pinto, Valdir Monteiro

; Perini, Waltesia

; Pereira, Gerson Fernando Mendes

; Miranda, Angélica Espinosa

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0277-2023

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Women living with human immunodeficiency virus (HIV) (WLWH) are more likely to be infected with the oncogenic human papillomavirus (HPV). We assessed the prevalence of high-risk (HR) (16/18/31/33/35/39/45/51/52/56/58/59/68/73/82), probable high-risk (pHR) (26/53/66), and low-risk (LR) (6/11/40/42/43/44/54/61/70) HPV types and their associated risk factors. Methods: This cross-sectional study of WLWH aged 18-64 years included one laboratory and eight HIV-specialty healthcare facilities in the pilot network. Descriptive statistics were used to assess sociodemographic and behavioral characteristics. Adjusted analyses were conducted to evaluate risk factors associated with HR and/or pHR HPV infection in WLWH. Results: From May/2021 to May/2022, 1,914 (92.5%) WLWH participated in the pilot study and had valid HPV-DNA results of self-collected vaginal samples. The median age of the participants was 45 years, 60.1% had ≥ 9 years of schooling, 80.5% were ≤ 18 years at first sexual intercourse, and 51.7% had > 4 sexual partners throughout life. The prevalence of any HPV type, HR HPV, pHR HPV, and LR HPV was 65.8%, 49.6%, 16.7%, and 40.0%, respectively. Age was inversely associated with pHR and/or HR-HPV (p < 0.001), and education level was inversely associated with HR-HPV (p = 0.003) types. Any HR or pHR was associated with being single (p = 0.029) and exchanging sex for drugs (p = 0.037). Conclusions: The prevalence of HPV, especially HR HPV, among WLWH is high in Brazil, highlighting the need for HPV screening in this population. Self-collection of vaginal samples is an important strategy for increasing testing access.

https://doi.org/10.1590/0037-8682-0277-2023

Benefícios previdenciários de pescadores artesanais e marisqueiras em comunidade quilombola no Nordeste do Brasil
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Bastos, Maria Luiza Almeida

; Carvalho, Thalyta Gleyane Silva de

; Knierim, Gislei Siqueira

; Machado, Jorge Mesquita Hued

; Fenner, André Luiz Dutra

; Silva, Fátima Cristina Cunha Maia

; Batista, Maximiria Holanda

; Ferreira, Marcelo José Monteiro

Revista Brasileira de Saúde Ocupacional

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2023, Volume 48 elocation e9

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: artisanal fishing and shellfish gathering are considered special activities under the Brazilian general social security system for the purposes of social security benefits. Objective: to describe the access to social security benefits for a traditional fishing quilombola community in northeastern Brazil, whose main occupational activity is shellfish extraction and processing. Methods: a cross-sectional descriptive study conducted in a community from Ilha da Maré, Salvador, Bahia, Brazil. Results: 213 fishermen (76.5% female) participated in the study, of which 62.9% did not receive social benefits. Although most participants undergoing an exhausting working hours (90.9%), with exposure to chemicals (83.9%), noise (69.9%) and solar radiation (88.2%), the majority of them do not earn an income that guarantees their family’s subsistence (79.6%). Conclusion: there is an important deficit in social security benefits access for a traditional quilombola population that meets the criteria for special insurance. Legislation must be adapted to ensure fairer access to social benefits for this population.

Resumo Introdução: a pesca artesanal e a mariscagem são consideradas atividades especiais, para fins de benefícios, no âmbito do Regime Geral de Previdência Social do Brasil. Objetivo: descrever o acesso aos benefícios previdenciários por uma população quilombola tradicional pesqueira no Nordeste do Brasil, cuja principal atividade ocupacional é a extração e beneficiamento de mariscos. Métodos: estudo transversal, descritivo, em uma comunidade da Ilha da Maré, em Salvador, Bahia, Brasil. Os dados foram coletados por meio de entrevistas, utilizando questionários padronizados. Resultados: participaram 213 pescadores artesanais e marisqueiras, 76,5% do sexo feminino. Dentre os participantes, 62,9% não recebem nenhum tipo de benefício previdenciário. Apesar de se submeter a uma jornada de trabalho exaustiva (90,9%), com exposição a substâncias químicas (83,9%), ruído (69,9%) e radiação solar (88,2%), a maioria não obtém rendimentos que garantam a subsistência familiar (79,6%). Conclusão: há um importante déficit no recebimento de benefícios previdenciários em uma população quilombola tradicional que atende aos critérios de segurados especiais. Sugere-se adequação da legislação, de forma que o acesso aos benefícios se torne mais justo para as comunidades tradicionais.

https://doi.org/10.1590/2317-6369/20821pt2023v48e9

Vínculo longitudinal da Estratégia Saúde da Família na linha de frente da pandemia da Covid-19
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Frota, Amanda Cavalcante

; Barreto, Ivana Cristina de Holanda Cunha

; Carvalho, André Luís Bonifácio de

; Ouverney, Assis Luiz Mafort

; Andrade, Luiz Odorico Monteiro de

; Machado, Nádia Maria da Silva

Saúde em Debate

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2022, Volume 46 N. spe1 Pages 131 - 151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este artigo analisa o processo de trabalho da Estratégia Saúde da Família (ESF) na pandemia da Covid-19 segundo o atributo do vínculo longitudinal da Atenção Primária à Saúde. Estudo transversal, de caráter descritivo e analítico, com levantamento de dados primários, coletados mediante inquérito nacional por meio de um survey eletrônico, de abrangência nacional, realizado no 2º semestre de convivência com a doença. No presente recorte, incluíram-se o Ceará e a Paraíba, estados do Nordeste com mais de 84% de cobertura da ESF. Prevaleceram as participações de trabalhadoras (962), sendo agentes comunitários de saúde (29%) e enfermeiras (26,61%), mulheres (81,19%), de 18 a 39 anos (61,85%), servidoras estatutárias (48,75%), atuantes em territórios urbanos (58,63%). Das participantes, 92,54% trabalhavam no período, sendo apenas 4,7% a distância. Em relação às atividades, 51,53% declararam estar ‘realizando atividades de rotina, como antes’; e 31,42% revelaram estar ‘priorizando atividades relacionadas a Covid-19’. Novos cadastros do Cartão SUS foram efetivados segundo 67,94% das participantes. A pesquisa confirma que a ESF é porta de entrada muito frequente, se não a principal, de casos de Covid-19 e que embora atenda às dimensões do atributo, está fragilizada em sua efetivação para o cuidado dos usuários adscritos.

ABSTRACT This paper analyzes the Family Health Strategy (ESF) work process in the Covid-19 pan- demic per the PHC longitudinal linkage attribute. This cross-sectional, descriptive, and analytical study collected primary data from a national electronic survey carried out from September to December 2020. Ceará and Paraíba, States of the Northeastern region with more than 84% ESF coverage, were included in this excerpt. The participation of female workers (962) prevailed, with Community Health Workers (ACS, 29%) and nurses (26.61%), women (81.19%), 18-39 years of age (61.85%), statutory public servants (48,75%), active in urban territories (58.63%). Approximately 92.54% of the participants worked in the period, with only 4.70% working remotely. A total of 51.53% stated that they were ‘carrying out routine activities, as before’, and 31.42% revealed they were ‘prioritizing activities related to Covid-19’. New SUS Card registrations were made according to 67.94% of the participants. The research confirms that the ESF is a very frequent gateway, if not the main one, for Covid-19 cases and that its effectiveness for the care of the registered users is weakened although it meets the dimensions of its attribute.

https://doi.org/10.1590/0103-11042022e109

Vínculo longitudinal da Estratégia Saúde da Família na linha de frente da pandemia da Covid-19
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Frota, Amanda Cavalcante

; Barreto, Ivana Cristina de Holanda Cunha

; Carvalho, André Luís Bonifácio de

; Ouverney, Assis Luiz Mafort

; Andrade, Luiz Odorico Monteiro de

; Machado, Nádia Maria da Silva

Saúde em Debate

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2022, Volume 46 N. spe1 Pages 131 - 151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0103-11042022e109

Factors associated with hospitalizations for Covid-19 in patients with rheumatoid arthritis: data from the Reumacov Brazil registry
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Gomides, Ana Paula Monteiro

; Albuquerque, Cleandro Pires de

; Mota, Licia Maria Henrique da

; Devidé, Guilherme

; Dias, Laiza Hombre

; Duarte, Angela Luzia Branco Pinto

; Giovelli, Raquel Altoé

; Karnopp, Thais Evelyn

; Lima, Hugo Deleon de

; Marinho, Adriana

; Oliveira, Marianne Schrader de

; Omura, Felipe

; Ranzolin, Aline

; Resende, Gustavo

; Ribeiro, Francinne Machado

; Ribeiro, Sandra Lúcia Euzébio

; Sacilotto, Nathália de Carvalho

; Santos, Wander Gonzaga dos

; Shinjo, Samuel Katsuyuki

; Studart, Samia Araujo de Sousa

; Teixeira, Flávia Patricia Sena

; Yazbek, Michel Alexandre

; Ferreira, Gilda Aparecida

; Monticielo, Odirlei A.

; Paiva, Eduardo

; Pileggi, Gecilmara Cristina Salviato

; Reis Neto, Edgard Torres dos

; Pinheiro, Marcelo de Medeiros

; Marques, Claudia D. L.

Advances in Rheumatology

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2022, Volume 62 elocation 13

Abstract: En | Text: En | PDF: En

Abstract Background: Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID 19 in these patients, especially in patients with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the risk factors associated with COVID 19 hospitalizations in patients with RA. Methods: This multicenter, prospective cohort study is within the ReumaCoV Brazil registry and included 489 patients with RA. In this context, 269 patients who tested positive for COVID 19 were compared to 220 patients who tested negative for COVID 19 (control group). All patient data were collected from the Research Electronic Data Capture database. Results: The participants were predominantly female (90.6%) with a mean age of 53 ±12 years. Of the patients with COVID 19, 54 (20.1%) required hospitalization. After multiple adjustments, the final regression model showed that heart disease (OR =4.61, 95% CI 1.06–20.02. P < 0.001) and current use of glucocorticoids (OR =20.66, 95% CI 3.09–138. P < 0.002) were the risk factors associated with hospitalization. In addition, anosmia was associated with a lower chance of hospitalization (OR =0.26; 95% CI 0.10–0.67, P < 0.005). Conclusion: Our results demonstrated that heart disease and the use of glucocorticoids were associated with a higher number of hospital admissions for COVID 19 in patients with RA. Trial registration: Brazilian Registry of Clinical Trials RBR 33YTQC.

https://doi.org/10.1186/s42358-022-00244-5

Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil
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Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Gomides Reis, Ana Paula Monteiro

; Reis Neto, Edgard Torres

; Abreu, Mirhelen Mendes

; Albuquerque, Cleandro Pires

; Araújo, Nafice Costa

; Bacchiega, Ana Beatriz

; Bianchi, Dante Valdetaro

; Bica, Blanca

; Bonfa, Eloisa Duarte

; Borba, Eduardo Ferreira

; Brito, Danielle Christinne Soares Egypto

; Duarte, Ângela Luzia Branco Pinto

; Santo, Rafaela Cavalheiro Espírito

; Fernandes, Paula Reale

; Guimarães, Mariana Peixoto

; Gomes, Kirla Wagner Poti

; Kakehasi, Adriana Maria

; Klumb, Evandro Mendes

; Lanna, Cristina Costa Duarte

; Marques, Claudia Diniz Lopes

; Monticielo, Odirlei André

; Mota, Licia Maria Henrique

; Munhoz, Gabriela Araújo

; Paiva, Eduardo Santos

; Pereira, Helena Lucia Alves

; Provenza, José Roberto

; Ribeiro, Sandra Lucia Euzébio

; Rocha Junior, Laurindo Ferreira

; Sampaio, Camila Santana Justo Cintra

; Sampaio, Vanderson Souza

; Sato, Emília Inoue

; Skare, Thelma

; de Souza, Viviane Angelina

; Valim, Valeria

; Lacerda, Marcus Vinícius Guimarães

; Xavier, Ricardo Machado

; Pinheiro, Marcelo Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 60

Abstract: En | Text: En | PDF: En

Abstract Background: There is a lack of information on the role of chronic use of hydroxychloroquine during the SARS-CoV-2 outbreak. Our aim was to compare the occurrence of COVID-19 between rheumatic disease patients on hydroxychloroquine with individuals from the same household not taking the drug during the first 8 weeks of community viral transmission in Brazil. Methods: This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. All information regarding COVID-19 symptoms, epidemiological, clinical, and demographic data were recorded on a specific web-based platform using telephone calls from physicians and medical students. COVID-19 was defined according to the Brazilian Ministry of Health (BMH) criteria. Mann-Whitney, Chi-square and Exact Fisher tests were used for statistical analysis and two binary Final Logistic Regression Model by Wald test were developed using a backward-stepwise method for the presence of COVID-19. Results: From March 29th to May 17st, 2020, a total of 10,443 participants were enrolled, including 5166 (53.9%) rheumatic disease patients, of whom 82.5% had systemic erythematosus lupus, 7.8% rheumatoid arthritis, 3.7% Sjögren’s syndrome and 0.8% systemic sclerosis. In total, 1822 (19.1%) participants reported flu symptoms within the 30 days prior to enrollment, of which 3.1% fulfilled the BMH criteria, but with no significant difference between rheumatic disease patients (4.03%) and controls (3.25%). After adjustments for multiple confounders, the main risk factor significantly associated with a COVID-19 diagnosis was lung disease (OR 1.63; 95% CI 1.03-2.58); and for rheumatic disease patients were diagnosis of systemic sclerosis (OR 2.8; 95% CI 1.19-6.63) and glucocorticoids above 10 mg/ day (OR 2.05; 95% CI 1.31-3.19). In addition, a recent influenza vaccination had a protective effect (OR 0.674; 95% CI 0.46-0.98). Conclusion: Patients with rheumatic disease on hydroxychloroquine presented a similar occurrence of COVID-19 to household cohabitants, suggesting a lack of any protective role against SARS-CoV-2 infection. Trial registration Brazilian Registry of Clinical Trials (ReBEC; RBR - 9KTWX6).

https://doi.org/10.1186/s42358-021-00217-0 22 downloads

Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
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Bonfiglioli, Karina Rossi

; Mota, Licia Maria Henrique da

; Ribeiro, Ana Cristina de Medeiros

; Kakehasi, Adriana Maria

; Laurindo, Ieda Maria Magalhães

; Giorgi, Rina Dalva Neubarth

; Duarte, Angela Luzia Branco Pinto

; Reis, Ana Paula Monteiro Gomides

; Souza, Mariana Peixoto Guimarães Ubirajara e Silva de

; Brenol, Claiton Viegas

; Pinheiro, Geraldo da Rocha Castelar

; Albuquerque, Cleandro Pires de

; Castro, Charlles Heldan de Moura

; Pinto, Gustavo Luiz Behrens

; Verztman, Jose Fernando

; Muniz, Luciana Feitosa

; Bertolo, Manoel Barros

; Pinto, Maria Raquel da Costa

; Louzada Júnior, Paulo

; Cruz, Vitor Alves

; Pereira, Ivanio Alves

; Freitas, Max Vitor Carioca de

; Cruz, Bóris Afonso

; Paiva, Eduardo

; Monticielo, Odirlei

; Provenza, José Roberto

; Xavier, Ricardo Machado

Advances in Rheumatology

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2021, Volume 61 elocation 70

Abstract: En | Text: En | PDF: En

Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.

https://doi.org/10.1186/s42358-021-00228-x

Oncicola venezuelensis () (Acanthocephala: Oligacanthorhynchidae) in Puma concolor in Rio de Janeiro, Brazil
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Palmer, João Pedro Siqueira

; Dib, Laís Verdan

; Lobão, Lucas Fernandes

; Pinheiro, Jessica Lima

; Ramos, Raissa Cristina Ferreira

; Uchoa, Claudia Maria Antunes

; Bastos, Otilio Machado Pereira

; Silva, Maria Eduarda Monteiro

; Nascimento, Jorge Luiz do

; Pissinatti, Alcides

; Barbosa, Alynne da Silva

Revista Brasileira de Parasitologia Veterinária

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2020, Volume 29 N. 3 elocation e009620

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Espécimes de Oncicola venezuelensis (Marteau, 1997) foram recuperados de fragmentos do tecido intestinal de uma fêmea de Puma concolor (Linn, 1771) encontrada morta em Petrópolis, Rio de Janeiro, em 2017. Um total de 140 helmintos foram recuperados. Cinco machos e 5 cinco fêmeas dos helmintos foram analisados morfologicamente, bem como 50 ovos dos parasitos recuperados no conteúdo intestinal. Morfologicamente, esses helmintos eram compatíveis com o gênero Oncicola, devido ao tamanho e formato da probóscide, o tamanho e disposição do leminisco e a morfometria dos ovos, que apresentaram membrana externa da casca delicada e clara. A partir da histopatologia, pode-se verificar que os helmintos estavam profundamente inseridos na mucosa, atingindo até a camada muscular. Um espécime também foi identificado molecularmente com primers universais que amplificam a região ITS-1.5.8S.ITS-2. Após as análises moleculares, foi verificado que os helmintos apresentavam 99% de identidade com sequência gênica de O. venezuelensis que está depositada no Genbank. É importante enfatizar, que esse parasito foi muito pouco relatado na literatura, demonstrando a importância deste relato.

Abstract Specimens of Oncicola venezuelensis (Marteau, 1977) were recovered from fragments of intestinal tissue of a female Puma concolar (Linn, 1771) found dead in Petrópolis, Rio de Janeiro in 2017. A total of 140 helminths were recovered. Five males and 5 females of the helminths were analyzed morphologically as well as 50 parasite eggs recovered in intestinal contents. Morphologically, these helminths were compatible with the genus Oncicola, because of the size and shape of the proboscis, the size and disposition of the lemnisci and the morphometry of the eggs, in which the external membrane of the shell was delicate and clear. From histopathology, the helminths were deeply embeded in the mucosa reaching up to the muscle layer. One specimen was also identified molecularly with universal primers that amplified the eukaryote region ITS1-5.8S-ITS2. The helminth showed 99% identity with the gene sequence of O. venezuelensis deposited in GenBank. It is important to emphasize, this parasite has been very little reported in the literature, which reinforces the importance of this report.

https://doi.org/10.1590/s1984-29612020046 745 downloads

10.

Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases
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Reis Neto, Edgard Torres dos

; Kakehasi, Adriana Maria

; Pinheiro, Marcelo de Medeiros

; Ferreira, Gilda Aparecida

; Marques, Cláudia Diniz Lopes

; Mota, Licia Maria Henrique da

; Paiva, Eduardo dos Santos

; Pileggi, Gecilmara Cristina Salviato

; Sato, Emília Inoue

; Reis, Ana Paula Monteiro Gomides

; Xavier, Ricardo Machado

; Provenza, José Roberto

Advances in Rheumatology

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2020, Volume 60 elocation 32

Abstract: En | Text: En | PDF: En

Abstract Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. We also discuss possible adverse effects, adding a practical and comprehensive approach to monitoring rheumatic patients during treatment with these drugs.

https://doi.org/10.1186/s42358-020-00134-8 2393 downloads

11.

Associação entre sinais de sofrimento psíquico até dezoito meses e rebaixamento da qualidade de vida aos seis anos de idade
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Mota, Angela Di Paolo

; Lerner, Rogério

; Escobar, Ana Maria de Ulhôa

; Kupfer, Maria Cristina Machado

; Rocha, Francisco Marcelo Monteiro da

; Santos, Luiz Silva dos

Psicologia USP

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dec 2015, Volume 26 N. 3 Pages 464 - 473

Resumo: A pedido do Ministério da Saúde foi desenvolvido e validado um protocolo de Indicadores clínicos de Risco para o Desenvolvimento Infantil (IRDI) para detectar riscos para transtornos psíquicos de desenvolvimento em bebês de 0 a 18 meses. Este trabalho teve como objetivo verificar a validade preditiva do IRDI, a partir de sua relação com dois instrumentos: o Autoquestionnaire Qualité de Vie Enfant Imagé (AUQUEI) e o Child Health Questionnaire (CHQ), ambos já validados no Brasil e aplicados aos seis anos de vida. A amostra foi composta por 46 crianças de três centros de saúde de São Paulo. Os resultados indicaram que o IRDI não se mostrou sensível à avaliação de qualidade de vida obtida com o uso do AUQUEI. No entanto, a associação estatisticamente significante encontrada entre resultados obtidos no IRDI e no CHQ mostrou maior capacidade do IRDI para predizer qualidade de vida relacionada ao índice psicossocial do que ao índice físico do mesmo instrumento.

Abstract: At the request of the Ministry of Health, a protocol of Clinical Risk Indicators for Child Development (IRDI) capable of detecting risk for psychic development disorders in infants aged between 0 and 18 months was developed and validated. This study aimed to verify the degree of association between IRDI and two other instruments for assessing quality of life: Autoquestionnaire Qualité de Vie Enfant Image - AUQUEI and Child Health Questionnaire - CHQ, both already validated in Brazil and applied at the age of six years. The sample comprised 46 children from three health centers in São Paulo, Brazil. The results indicated that IRDI was not sensitive to the assessment of quality of life achieved by using AUQUEI. However, a statistically significant association found between the results of IRDI and CHQ showed higher capacity of IRDI to predict quality of life related to psychosocial index than the physical index of the same instrument.

Resumen: Un protocolo de Indicadores clínicos de Riesgo para el Desarrollo Infantil (IRDI) fue desarrollado y validado a demanda del Ministerio de Salud para detectar los riesgos de trastornos psíquicos de desarrollo en los niños de 0 a 18 meses. Este estudio tuvo como objetivo determinar el grado de asociación entre el IRDI y otros dos instrumentos que evalúan la calidad de vida: el Autoquestionnaire Qualité de Vie Enfant Imagen (AUQUEI) y el Child Health Questionnaire (CHQ), ambos ya validados en Brasil y aplicados a los seis años de edad. La muestra consta de 46 niños de tres centros de salud de São Paulo. Los resultados indicaron que el IRDI no se mostró sensible a la evaluación de la calidad de vida obtenida mediante el uso del AUQUEI. Sin embargo, la asociación estadísticamente significativa encontrada entre los resultados obtenidos en el IRDI y CHQ mostró una mayor capacidad del IRDI para predecir la calidad de vida relacionada al índice psicosocial que al físico del mismo instrumento.

Résumé: À la demande du Ministère de la Santé, un groupe de psychanalystes a développé et validé un protocole d'Indicateurs de Risque Cliniques pour le Développement de l'Enfant (IRDI), capable de détecter les risques de troubles dans le développement mentaux chez bébés d'âge entre 0 et 18 mois. Cette étude visait à déterminer le degré d'association entre l'IRDI et des deux autres instruments qui évaluent la qualité de vie : l'Autoquestionnaire Qualité de Vie Enfant Imagé (AUQUEI) et le Child Health Qtuestionnaire (CHQ). Les deux ont été validés au Brésil et on été appliqués aux enfants à l'áge de six ans. L'échantillon comprenait 46 enfants hospitalisés dans trois centres de santé à São Paulo, au Brésil. Les résultats indiquent que l'IRDI n'est pas sensible à l'évaluation de la qualité de vie obtenue par l'AUQUEI. Cependant, l'association statistiquement significatif trouvée dans les résultats a montrée une capacité du IRDI de prédire la qualité de vie liée à l'index psychosocial plus grande que de laquelle liée à l'index physique du même instrument.

https://doi.org/10.1590/0103-656420130043 4780 downloads

12.

Alterações físicas e químicas em cebolas armazenadas sob refrigeração
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Melo, Cleneide Oliveira

; Moretti, Celso Luiz

; Machado, Cristina Maria Monteiro

; Mattos, Leonora Mansur

; Muniz, Lidiane Batista

Ciência Rural

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nov 2012, Volume 42 N. 11 Pages 2078 - 2084

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Bulbos de cebolas armazenados sob refrigeração sofrem alterações físicas e químicas. Entretanto a intensidade das alterações depende das condições de armazenamento e cultivar. Este trabalho objetivou avaliar alterações em cebolas das cultivares 'Beta Cristal' e 'Óptima' armazenadas sob refrigeração. Bulbos colhidos no campo experimental da Embrapa Hortaliças - Brasília DF, após cura, foram transportados para o laboratório onde foram selecionados e armazenados a 5±1°C e umidade relativa de 85±5%, durante 60 dias. A cada 10 dias, foram feitas análises de perda de massa, cor (L*), firmeza (N), pungência, acidez titulável e sólidos solúveis. Observou-se, durante o armazenamento, nas duas cultivares estudadas, incremento na perda de massa, redução nos teores de sólidos solúveis e na acidez titulável. Houve grande variação na luminosidade dos bulbos durante o armazenamento. Entretanto, após 60 dias, o brilho das cebolas das duas cultivares foi significativamente maior, quando comparado ao início dos experimentos. Houve aumento significativo da firmeza dos bulbos da cultivar 'Óptima'. Ao final do experimento, a pungência foi 6 e 5 vezes maior nas cultivares 'Beta Cristal' e 'Óptima', respectivamente, em relação ao início do período de armazenamento.

Storage under low temperatures, immediately after the harvest, is the most used technique to extend the shelf life of different fresh produce. The present work was carried out with the objective of assessing physical and chemical alterations in onions stored under refrigeration. Onions (Allium cepa L.) cultivars 'Beta Cristal' and 'Óptima' were harvested at Embrapa Vegetables experimental fields, were cured and taken to the Food Science and Technology Lab where bulbs were selected and stored at 5±1°C and 85±5% relative humidity for 60 days. Every 10 days bulbs wee assessed for dry matter, mass loss (%), brightness, firmness, titratable acidity, soluble solids and pungency. It was observed during the storage period for both cultivars an increase in weight loss, a reduction in the content of soluble solids and titratable acidity. There was a significant variation in bulbs brightness during storage. After 60 days, onions from both cultivars presented higher brightness comparing to the beginning of the experiments. There was a significant increase in firmness for 'Óptima' bulbs. At the end of the experiment, pungency was 6 and 5 times higher in 'Beta Cristal' and 'Óptima' cultivars, respectively, when compared to the values observed in the beginning of the experiment.

3110 downloads Cited 1 time in SciELO

13.

Gestão participativa no SUS e a integração ensino, serviço e comunidade: a experiência da Liga de Saúde da Família, Fortaleza, CE
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Barreto, Ivana Cristina de Holanda Cunha

; Andrade, Luiz Odorico Monteiro de

; Moreira, Ana Ester Maria Melo

; Machado, Márcia Maria Tavares

; Silva, Maria Rocineide Ferreira da

; Oliveira, Lúcia Conde de

; Moura, Walda Viana Brígido

; Góis, Cezar Wagner de Lima

; Cavalcanti, Caio Garcia Correia Sá

; Ávila, Maria Marlene Marques

; Araujo, Maria Fátima Maciel

; Silva, Lucilane Maria Sales da

; Peixoto, Maria Graça Barbosa

; Arruda, Carlos André Moura

; Silva, André Luís Façanha da

; Lins, Herley Medeiros

Saúde e Sociedade

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may 2012, Volume 21 Suppl. 1 Pages 80 - 93

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Fruto da experiência de duas universidades públicas e uma privada, o Projeto de Extensão Liga Saúde da Família (LSF) constitui-se numa estratégia de gestão participativa no campo da formação de profissionais da área da saúde, com base nos conceitos de educação permanente em saúde, educação popular em saúde, equipe multiprofissional e interdisciplinar, atenção primária à saúde, promoção da saúde, estratégia saúde da família, metodologias participativas de pesquisa e atuação inserida no território vivo. Este relato apresenta a experiência da integração ensino-serviço-comunidade por meio do Projeto de Extensão Liga Saúde da Família, no contexto do Sistema Municipal de Saúde Escola (SMSE), em Fortaleza-Ceará, que dialoga com a gestão participativa no Sistema Único de Saúde (SUS). Esta proposta do LSF foi implantada no SMSE a partir de uma ação apoiada pelo sistema de saúde de Fortaleza que visa potencializar os espaços de co-gestão docente-assistencial, por meio da proposta do método da roda e da tenda invertida. O protagonismo dos integrantes e da comunidade na construção das atividades do projeto e a ampliação do olhar crítico sobre a realidade social e do trabalho em saúde estão entre os maiores avanços surgidos dessa experiência. Esse projeto permitiu a integração ensino - serviço - comunidade, atendendo a uma perspectiva de gestão participativa e dialógica.

As a result of the experience of two public universities and a private one, the Extension Project "Family Health League" (LSF) introduced a participative management strategy in the field of education of health professionals, with the support of power-ideas such as permanent education in health, popular education, multiprofessional and interdisciplinary groups, primary health attention, family health strategy, participative methodologies and practice inserted in a live territory. This report aims to introduce an experience of integrating teaching to community service through the Family Health League Extension Project (LSF), in the context of the Health-School Municipal System (SMSE) in the city of Fortaleza, Ceará, Brazil. This experience was planned in the spirit of participative management in the National Health System (SUS). The proposal of LSF emerges, in the SMSE, from a recommendation supported by the city's health system which aimed at improving co-management spaces of education and services and used the methods of circle discussion and inverted tent. The protagonism of the project members and of the community in the organization of the project's activities and the amplification of a critical view over social reality and health work are amongst the major advances which emerged from this experience. This project has made possible the integration of teaching, health service and community, from the perspective of a communicative and participative management.

10997 downloads Cited 2 times in SciELO

14.

Gestão participativa no SUS e a integração ensino, serviço e comunidade: a experiência da Liga de Saúde da Família, Fortaleza, CE
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Barreto, Ivana Cristina de Holanda Cunha

; Andrade, Luiz Odorico Monteiro de

; Moreira, Ana Ester Maria Melo

; Machado, Márcia Maria Tavares

; Silva, Maria Rocineide Ferreira da

; Oliveira, Lúcia Conde de

; Moura, Walda Viana Brígido

; Góis, Cezar Wagner de Lima

; Cavalcanti, Caio Garcia Correia Sá

; Ávila, Maria Marlene Marques

; Araujo, Maria Fátima Maciel

; Silva, Lucilane Maria Sales da

; Peixoto, Maria Graça Barbosa

; Arruda, Carlos André Moura

; Silva, André Luís Façanha da

; Lins, Herley Medeiros

Saúde e Sociedade

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may 2012, Volume 21 Suppl. 1 Pages 80 - 93

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

397 downloads

15.

The effectiveness of chemical denture cleansers and ultrasonic device in biofilm removal from complete dentures
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Cruz, Patrícia Costa

; Andrade, Ingrid Machado de

; Peracini, Amanda

; Souza-Gugelmin, Maria Cristina Monteiro de

; Silva-Lovato, Cláudia Helena

; Souza, Raphael Freitas de

; Paranhos, Helena de Freitas Oliveira

Journal of Applied Oral Science

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dec 2011, Volume 19 N. 6 Pages 668 - 673

Abstract: En | Text: En | PDF: En

Adequate denture hygiene can prevent and treat infection in edentulous patients. They are usually elderly and have difficulty for brushing their teeth. OBJECTIVE: This study evaluated the efficacy of complete denture biofilm removal using chemical (alkaline peroxide-effervescent tablets), mechanical (ultrasonic) and combined (association of the effervescent and ultrasonic) methods. MATERIAL AND METHODS: Eighty complete denture wearers participated in the experiment for 21 days. They were distributed into 4 groups (n=20): (1) Brushing with water (Control); (2) Effervescent tablets (Corega Tabs); (3) Ultrasonic device (Ultrasonic Cleaner, model 2840 D); (4) Association of effervescent tablets and ultrasonic device. All groups brushed their dentures with a specific brush (Bitufo) and water, 3 times a day, before applying their treatments. Denture biofilm was collected at baseline and after 21 days. To quantify the biofilm, the internal surfaces of the maxillary complete dentures were stained and photographed at 45º. The photographs were processed and the areas (total internal surface stained with biofilm) quantified (Image Tool 2.02). The percentage of the biofilm was calculated by the ratio between the biofilm area multiplied by 100 and the total area of the internal surface of the maxillary complete denture. RESULTS: The Kruskal-Wallis test was used for comparison among groups followed by the Dunn multiple-comparison test. All tests were performed respecting a significance level of 0.05. Significant difference was found among the treatments (KW=21.18; P<0.001), the mean ranks for the treatments and results for Dunn multiple comparison test were: Control (60.9); Chemical (37.2); Mechanical (35.2) and Combined (29.1). CONCLUSION: The experimental methods were equally effective regarding the ability to remove biofilm and were superior to the control method (brushing with water). Immersion in alkaline peroxide and ultrasonic vibration can be used as auxiliary agents for cleaning complete dentures.

9993 downloads Cited 4 times in SciELO

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