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ABSTRACT: Pythiosis is the disease caused by aquatic oomycetes of the genus Pythium. In dogs the typical course of the disease involves the gastrointestinal tract, characterized by transmural thickening of the stomach or intestines. However, infection by Pythium spp. has only rarely been recognized as a cause of esophagitis in dogs. Thus, the present reports a case of esophageal and gastric pythiosis in an eight-month-old female pit bull dog. The dog was attended at the hospital after two months presenting regurgitation and dyspnea. It was reported that the dog lived in an urban area and had no previous sanitary issues. At clinical examination it was noted that the dog presented crackling sounds at pulmonary auscultation. A support therapy accompanied by antibiotics has been employed; however, 22 days after hospitalization the clinical condition worsened, and the dog died. At necropsy, the wall of the distal segment of the esophagus and the cardia and part of the fundus of the stomach were expanded by a focal extensive irregular intramural annular mass. Additionally, there was a transmural esophageal fistula. At histology, the walls of the esophagus and stomach were extensively expanded by multifocal extensive areas of necrosis, associated with a pyogranulomatous infiltrate and abundant granulation tissue containing multiple negative images of hyphae that were highlighted by silver impregnation (Grocott). Furthermore, immunohistochemistry and PCR for P. insidiosum were both positive in samples of paraffin-embedded esophageal tissue.

RESUMO: A Pitiose é uma doença causada por oomicetos aquáticos do gênero Pythium. Em cães o curso típico da doença envolve o trato gastrointestinal, caracterizado por espessamento transmural do estômago ou intestinos. No entanto, a infecção por Pythium spp. raramente foi reconhecida como causa de esofagite em caninos. Assim, o presente trabalho tem como objetivo relatar um caso de pitiose esofágica e gástrica em um canino Pit Bull fêmea de oito meses de idade. O cão foi recebido no hospital com histórico de regurgitação e dispneia durante dois meses. Foi relatado que o animal era de um domicílio de área urbana e não possuía histórico pregresso de enfermidades. No exame clínico contatou-se ainda crepitações à ausculta pulmonar. Foi instituído tratamento de suporte e antibioticoterapia, porém após 22 dias de internação, o cão evoluiu para o óbito. Na necropsia, as paredes do segmento distal do esôfago e o cárdia e parte do fundo do estômago estavam expandidos por uma massa anular intramural focalmente extensiva e irregular. Além disso, havia uma fístula esofágica transmural. À histologia, as paredes do esôfago e do estômago apresentavam-se difusamente expandidas por áreas multifocais extensas de necrose, associadas a infiltrado piogranulomatoso, abundante proliferação de fibroblastos imaturos, neovascularização e contendo múltiplas imagens negativas de hifas realçadas pela impregnação por prata (Grocott). Além disso, tanto a imuno-histoquímica como PCR para P. insidiosum foram positivas em amostras de esôfago embebidas em parafina.

https://doi.org/10.1590/0103-8478cr20230272

Brain-derived neurotrophic factor serum levels following ketamine and esketamine intervention for treatment-resistant depression: secondary analysis from a randomized trial
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Caliman-Fontes, Ana Teresa

; Leal, Gustavo C.

; Correia-Melo, Fernanda S.

; Paixao, Camilla S.

; Carvalho, Michelle S.

; Jesus-Nunes, Ana Paula

; Vieira, Flavia

; Magnavita, Guilherme

; Bandeira, Igor D.

; Mello, Rodrigo P.

; Beanes, Graziele

; Silva, Samantha S.

; Echegaray, Mariana

; Carvalho, Lucas P.

; Machado, Paulo

; Sampaio, Aline S.

; Cardoso, Taiane de A.

; Kapczinski, Flávio

; Lacerda, Acioly L. T.

; Quarantini, Lucas C.

Trends in Psychiatry and Psychotherapy

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2023, Volume 45 elocation e20210298

Abstract: En | Text: En | PDF: En

Abstract Objectives Evidence suggests that ketamine’s influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion There was no significant treatment impact on BDNF serum levels – neither with ketamine nor esketamine – despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion. This clinical trial is registered on the Japan Primary Registries Network: UMIN000032355.

https://doi.org/10.47626/2237-6089-2021-0298

Avaliação no Mundo Real de um Stent Eluidor de Sirolimus de Hastes Ultrafinas em Pacientes com Infarto do Miocárdio com Supradesnivelamento do Segmento ST Submetidos à Intervenção Coronária Percutânea Primária (Registro INSTEMI)
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Araujo, Gustavo N.

; Machado, Guilherme P.

; Moura, Marcia

; Silveira, Anderson D.

; Bergoli, Luiz Carlos

; Fuchs, Felipe Costa

; Gonçalves, Sandro Cadaval

; Wainstein, Rodrigo Vugman

; Lemos, Pedro A.

; Quadros, Alexandre S.

; Wainstein, Marco V.

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 6 elocation e20220594

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The current gold standard of coronary drug-eluting stents (DES) consists of metal alloys with thinner struts and bioresorbable polymers. Objectives Our aim was to compare an ultrathin strut, sirolimus-eluting stent (Inspiron®) with other third-generation DES platforms in patients with ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous coronary intervention (PCI). Methods We analyzed data from a STEMI multicenter registry from reference centers in the South Region of Brazil. All patients were submitted to primary PCI, either with Inspiron® or other second- or third-generation DES. Propensity score matching (PSM) was computed to generate similar groups (Inspiron® versus other stents) in relation to clinical and procedural characteristics. All hypothesis tests had a two-sided significance level of 0.05. Results From January 2017 to January 2021, 1711 patients underwent primary PCI, and 1417 patients met our entry criteria (709 patients in the Inspiron® group and 708 patients in the other second- or third-generation DES group). After PSM, the study sample was comprised of 706 patients (353 patients in the Inspiron® group and 353 patients in the other the other second- or third-generation DES group). The rates of target vessel revascularization (OR 0.52, CI 0.21 – 1.34, p = 0.173), stent thrombosis (OR 1.00, CI 0.29 – 3.48, p = 1.000), mortality (HR 0.724, CI 0.41 – 1.27, p = 0.257), and major cardiovascular outcomes (OR 1.170, CI 0.77 – 1.77, p = 0.526) were similar between groups after a median follow-up of 17 months. Conclusion Our findings show that Inspiron® was effective and safe when compared to other second- or third-generation DES in a contemporary cohort of real-world STEMI patients submitted to primary PCI.

Resumo Fundamento O padrão-ouro atual dos stents farmacológicos (SF) coronários consiste em ligas metálicas com hastes mais finas e polímeros bioabsorvíveis. Objetivos Nosso objetivo foi comparar um stent eluidor de sirolimus de hastes ultrafinas (Inspiron®) com outras plataformas de SF de terceira geração em pacientes com infarto do miocárdio com supradesnivelamento do segmento ST (IAMCSST) submetidos à intervenção coronária percutânea (ICP) primária. Métodos Analisamos dados de um registro multicêntrico de IAMCSST de centros de referência da Região Sul do Brasil. Todos os pacientes foram submetidos à ICP primária, seja com Inspiron® ou outro SF de segunda ou terceira geração. Foi calculado pareamento por escore de propensão (PEP) para gerar grupos semelhantes (Inspiron® versus outros stents) em relação às características clínicas e do procedimento. Todos os testes de hipótese tiveram um nível de significância bilateral de 0,05. Resultados De janeiro de 2017 a janeiro de 2021, 1.711 pacientes foram submetidos à ICP primária, e 1.417 pacientes preencheram nossos critérios de inclusão (709 pacientes no grupo Inspiron® e 708 pacientes no grupo dos outros SF de segunda ou terceira geração). Após PEP, a amostra do estudo foi composta por 706 pacientes (353 pacientes no grupo Inspiron® e 353 pacientes no grupo dos demais SF de segunda ou terceira geração). As taxas de revascularização do vaso alvo (odds ratio [OR] 0,52; intervalo de confiança [IC] 0,21 a 1,34; p = 0,173), trombose de stent (OR 1,00; IC 0,29 a 3,48;p = 1,000), mortalidade (hazard ratio 0,724; IC 0,41 a 1,27; p = 0,257) e os desfechos cardiovasculares maiores (OR 1,170; IC 0,77 a 1,77; p = 0,526) foram semelhantes entre os grupos após um acompanhamento mediano de 17 meses. Conclusão Nossos achados mostram que o stent Inspiron® foi eficaz e seguro quando comparado a outros SF de segunda ou terceira geração em uma coorte contemporânea do mundo real de pacientes com IAMCSST submetidos à ICP primária.

https://doi.org/10.36660/abc.20220594

Diferenças entre os Sexos nos Desfechos de Pacientes com Infarto do Miocárdio com Supradesnivelamento do Segmento ST Submetidos à Intervenção Coronária Percutânea Primária
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Milan, Victoria B.

; Alves, Yasmin F. S.

; Machado, Guilherme P.

; Araujo, Gustavo Neves de

; Krepsky, Ana Maria

; Chies, Angelo

; Niches, Matheus

; Fracasso, Julia

; Goncalves, Sandro Cadaval

; Wainstein, Marco

; Polanczyk, Carisi Anne

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 6 elocation e20220673

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Several studies have shown that women are usually undertreated and have worse outcomes after ST-segment elevation myocardial infarction (STEMI), hence the need to investigate questions related to sex in Brazil to better deal with the problem. Objective To determine whether female sex is still associated with adverse events in a contemporary cohort of patients with STEMI undergoing primary percutaneous coronary intervention (pPCI). Methods This was a prospective cohort study of STEMI patients submitted to pPCI in a tertiary university hospital between March 2011 and December 2021. Patients were categorized into groups based on their sex at birth. The primary clinical outcome was long-term MACCE. Patients were followed-up for up to five years. All hypothesis tests had a two-sided significance level of 0.05. Results Among 1457 patients admitted with STEMI in the study period, 1362 were included and 468 (34.4%) were women. Female patients had a higher prevalence of hypertension (73% vs. 60%, p <0.001), diabetes (32% vs. 25%, p=0.003) and Killip class 3-4 at hospital admission (17% vs. 12%, p=0.01); TIMI risk score was higher among women (4 [2, 6] vs. 3 [2, 5], p<0.001). In-hospital mortality was not different between groups (12.8% vs. 10.5%, p=0.20). In-hospital MACCE (16.0% vs. 12.6%, p=0.085) and long-term MACCE (28.7% vs. 24.4%, p=0.089) were numerically higher in women, with borderline significance. After multivariate analysis, female sex was not associated with MACCE (HR = 1.14; 95% CI 0.86 – 1.51; p = 0.36). Conclusion In a prospective cohort of STEMI patients submitted to pPCI, female patients were older and had more comorbidities at baseline, but no significant differences were found in terms of long-term adverse outcomes.

Resumo Fundamento Vários estudos têm mostrado que as mulheres não recebem tratamento adequado e apresentam piores desfechos após infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAMCSST). Por isso, é necessário investigar questões relacionadas ao gênero para melhor lidar com esse problema no Brasil. Objetivo Determinar se existe associação entre o sexo feminino e eventos adversos em uma coorte contemporânea de pacientes com IAMCSST submetidos à intervenção coronária percutânea primária (ICPp). Métodos Este foi um estudo prospectivo do tipo coorte de pacientes com IAMCSST submetidos à ICPp em um hospital universitário terciário entre março de 2011 e dezembro de 2021. Os pacientes foram categorizados em grupos de acordo com o sexo ao nascimento. O primeiro desfecho clínico foi ECAM em longo prazo. Os pacientes foram acompanhados por um período máximo de cinco anos. Um nível de significância bilateral de 0,05 foi aplicado em todos os testes de hipóteses. Resultados Entre os 1457 pacientes internados por IAMCSST no período do estudo, 1362 foram incluídos e 468 (34,4%) eram do sexo feminino. As mulheres apresentaram maior prevalência de hipertensão (73% vs. 60%, p<0,001), diabetes (32% vs. 25%, p=0,003) e classe Killip 3-4 na internação (17% vs. 12%, p=0,01); o escore de risco TIMI foi maior nas mulheres [4 (2, 6) vs. 3 (2, 5), p<0.001]. A mortalidade hospitalar não foi diferente entre os grupos (12,8% vs. 10,5%; p=0,20). Os ECAMs foram numericamente maiores nas mulheres que nos homens tanto durante a internação (16,0% vs. 12,6%, p=0,085) como em longo prazo (28,7% vs. 24,4%, p=0,089), com significância limítrofe. Após a análise multivariada, o sexo feminino não foi associado a ECAMs (HR = 1,14; IC95% 0,86 – 1,51; p = 0,36). Conclusão Em uma coorte prospectiva contemporânea de pacientes com IAMCSST submetidos à ICPp, pacientes do sexo feminino apresentaram idade mais avançada e mais comorbidades no basal que os pacientes do sexo masculino, mas não houve diferenças significativas entre os sexos quanto aos desfechos adversos no hospital ou em longo prazo.

https://doi.org/10.36660/abc.20220673

Lagged response of Tropical Atlantic Ocean to cold and fresh water pulse from Antarctic sea ice melting
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TORRES, ANA LAURA R.

; PARISE, CLAUDIA K.

; PEZZI, LUCIANO P.

; QUEIROZ, MICHELLY G. DOS SANTOS

; MACHADO, ADILSON M.B.

; CERVEIRA, GABRIEL S.

; CORREIA, GUSTAVO S.

; BARBOSA, WESLEY L.

; LIMA, LEONARDO G. DE

; SUTIL, UESLEI A.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Suppl. 1 elocation e20210800

Abstract: En | Text: En | PDF: En

Abstract The formation of dense water masses at polar regions has been largely influenced by climate changes arising from global warming. In this context, based on ensemble simulations with a coupled model we evaluate the meridional shift of a climate signal (i.e., a cold and fresh water input pulse generated from melting of positive Antarctic sea ice (ASI) extremes) towards the Tropical Atlantic Ocean (TAO). This oceanic signal propagated from Southern Ocean towards the equator through the upper layers due to an increase in its buoyance. Its northward shift has given by the Subantarctic Mode Water (SAMW) and Antarctic Intermediate Water (AAIW) flows, that inject cold and fresh mode/intermediate waters from into subtropical basin. The signal has reached low latitudes through the equatorial upwelling and spreads out southwards, through the upper branch of southern subtropical gyre. We concluded that 10 years of coupled simulations was enough time to propagate the climate signal generated by ASI positive extremes melting, which reached TOA around 2 year later. The oceanic connection between Southern Ocean and TAO is indeed established within the timescale analyzed in the study (10 years). Nonetheless, the period needed to completely dissipate the disturbance generated from ASI seems to be longer.

https://doi.org/10.1590/0001-3765202220210800

Characteristics and Surgical Outcomes in Very Elderly Patients (≥75 years) with Renal Cell Carcinoma: Data from the Latin American Renal Cancer Group
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Garza-Gangemi, Adrián M.

; Castillejos-Molina, Ricardo A.

; Gueglio, Guillermo

; Tobia-Gonzalez, Ignacio P.

; Jurado, Alberto M.

; Meza-Montoya, Luis

; Scorticati, Carlos H.

; Henriques-da-Costa, Walter

; Yandian, Juan

; Ubillos, Luis

; Glina, Sidney

; Tobias-Machado, Marcos

; Rodríguez-Faba, Oscar

; Ameri, Carlos

; Nolazco, Alejandro

; Martinez, Pablo

; Franco Carvalhal, Gustavo

; Bengio, Ruben G.

; Arribillaga, Leandro Cristian

; Langenhin, Raúl

; Muguruza, Diego

; Campos-Salcedo, José G.

; Bravo-Castro, Edgar I.

; Mingote, Pablo A.

; Ginestar, Nicolás

; Autran-Gomez, Ana M.

; Puente, Roberto

; Decia, Ricardo

; Cardoso-Guimarães, Gustavo

; Palou-Redorta, Joan

; Abreu-Clavijo, Diego

; Cassio-Zequi, Stenio de

; Rodriguez-Covarrubias, Francisco T.

Revista de investigación clínica

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oct 2020, Volume 72 N. 5 Pages 308 - 315

Abstract: En | Text: En | PDF: En

Background: The incidence of renal cell carcinoma (RCC) is increasing globally due to an aging population and widespread use of imaging studies. Objective: The aim of this study was to describe the characteristics and perioperative outcomes of RCC surgery in very elderly patients (VEP), ≥ 75 years of age. Methods: This is a retrospective comparative study of 3656 patients who underwent the treatment for RCC from 1990 to 2015 in 28 centers from eight Latin American countries. We compared baseline characteristics as well as clinical and perioperative outcomes according to age groups (<75 vs. ≥75 years). Surgical complications were classified with the Clavien-Dindo score. We performed logistic regression analysis to identify factors associated with perioperative complications. Results: There were 410 VEP patients (11.2%). On bivariate analysis, VEP had a lower body mass index (p < 0.01) and higher ASA score (ASA >2 in 26.3% vs. 12.4%, p < 0.01). There was no difference in performance status and clinical stage between the study groups. There were no differences in surgical margins, estimated blood loss (EBL), complication, and mortality rates (1.3% vs. 0.4%, p = 0.17). On multivariate regression analysis, age ≥75 years (odds ratio [OR] 2.33, p < 0.01), EBL ≥ 500 cc (OR 3.34, p < 0.01), and > pT2 stage (OR 1.63, p = 0.04) were independently associated with perioperative complications. Conclusions: Surgical resection of RCC was safe and successful in VEP. Age ≥75 years was independently associated with 30-day perioperative complications. However, the vast majority were low-grade complications. Age alone should not guide decision-making in these patients, and treatment must be tailored according to performance status and severity of comorbidities. (REV INVEST CLIN. 2020;72(5):308-15)

https://doi.org/10.24875/ric.20000018 141 downloads

MORPHOLOGICAL AND PHYSIOLOGICAL PARAMETERS IN YOUNG PLANTS OF Cordia trichotoma SUBMITTED TO THE APPLICATION OF PHOSPHORUS IN THE SOIL
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Berghetti, Álvaro Luís Pasquetti

; Araujo, Maristela Machado

; Tabaldi, Luciane Almeri

; Aimi, Suelen Carpenedo

; Tonetto, Thaise da Silva

; Turchetto, Felipe

; Brunetto, Gustavo

Revista Árvore

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2020, Volume 44 elocation e4404

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A aplicação de doses de fósforo (P) no solo pode aumentar o crescimento de espécies arbóreas nativas de interesse econômico e ambiental, como a Cordia trichotoma. Assim, esta pesquisa tem por objetivo avaliar parâmetros morfológicos e fisiológicos em mudas de C. trichotoma cultivadas em solo com aumento do teor de P. O experimento foi conduzido em casa de vegetação, em vasos com 2,5 dm-3 de solo, com quatro doses de P (0, 150, 300 e 450 mg dm-3) e seis repetições. O teor de P no solo, as concentrações de P nas folhas, os atributos morfológicos (altura, diâmetro do coleto, matéria seca aérea, matéria seca radicular e área foliar) e os atributos fisiológicos (teor de pigmentos fotossintéticos e fluorescência da clorofila a) foram determinados aos 180 dias após o transplante. O incremento no teor de P disponível no solo permitiu maior absorção desse elemento pelas raízes das plantas, elevando a concentração nas folhas. Isso favoreceu o metabolismo energético das plantas, proporcionando maior crescimento. Além disso, o maior influxo e acúmulo de P na planta quando utilizado 450 mg dm-3, incrementou a concentração dos pigmentos fotossintéticos e elevou a capacidade fotossintética das mudas de C. trichotoma. O maior aproveitamento da energia luminosa pelo fotossistema II (Fv/Fm = 0,76) foi observado nas mudas cultivadas com 450 mg dm-3 de P, com aumento de 95% quando comparadas às mudas sem adição de P. Assim, percebemos que essa espécie arbórea, é exigente e responsiva em relação ao maior teor de P disponível no solo.

ABSTRACT The application of phosphorus (P) doses in the soil can increase the growth of native tree species of economic and environmental interest, such as Cordia trichotoma. Thus, this research aims to evaluate the morphological and the physiological parameters in C. trichotoma seedlings, cultivated in soil with increased P content. The experiment was conducted under greenhouse conditions in pots with 2.5 dm-3 of soil, four doses of P (0, 150, 300 and 450 mg dm-3), and six replicates. P content in the soil, P concentrations in the leaves, morphological attributes (height, stem diameter, aerial dry matter, root dry matter, and leaf area) and physiological attributes (photosynthetic pigment content and chlorophyll α fluorescence) were determined 180 days after transplantation. The increase in the available P content in the soil allowed greater absorption of this element by the plant’s roots, increasing the concentration in the leaves, and therefore favoring the energetic metabolism of the plants. In addition, the higher influx and accumulation of P in the plant when 450 mg dm-3 was used, increased the concentration of the photosynthetic pigments and increased the photosynthetic capacity of the C. trichotoma seedlings. The highest use of the light energy by photosystem II (Fv/Fm = 0.76) was observed in the seedlings cultivated with 450 mg dm-3 of P, with a 95% increase when compared to seedlings without P. Thus, we observed that this tree species is demanding and responsive to the higher P content available in the soil.

https://doi.org/10.1590/1806-908820200000004 1150 downloads

Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon
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Pratt-Riccio, Lilian Rose

; Baptista, Bárbara de Oliveira

; Torres, Vanessa Rodrigues

; Bianco-Junior, Cesare

; Perce-Da-Silva, Daiana de Souza

; Riccio, Evelyn Kety Pratt

; Lima-Junior, Josué da Costa

; Totino, Paulo Renato Rivas

; Cassiano, Gustavo Capatti

; Storti-Melo, Luciane Moreno

; Machado, Ricardo Luiz Dantas

; de Oliveira-Ferreira, Joseli

; Banic, Dalma Maria

; Carvalho, Leonardo José de Moura

; Daniel-Ribeiro, Cláudio Tadeu

Memórias do Instituto Oswaldo Cruz

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2019, Volume 114 elocation e190054

Abstract: En | Text: En | PDF: En

BACKGROUND The central repetitive region (CRR) of the Plasmodium vivax circumsporozoite surface protein (CSP) is composed of a repetitive sequence that is characterised by three variants: VK210, VK247 and P. vivax-like. The most important challenge in the treatment of P. vivax infection is the possibility of differential response based on the parasite genotype. OBJECTIVES To characterise the CSP variants in P. vivax isolates from individuals residing in a malaria-endemic region in Brazil and to profile these variants based on sensitivity to chloroquine and mefloquine. METHODS The CSP variants were determined by sequencing and the sensitivity of the P. vivax isolates to chloroquine and mefloquine was determined by Deli-test. FINDINGS Although five different allele sizes were amplified, the sequencing results showed that all of the isolates belonged to the VK210 variant. However, we observed substantial genetic diversity in the CRR, resulting in the identification of 10 different VK210 subtypes. The frequency of isolates that were resistant to chloroquine and mefloquine was 11.8 and 23.8%, respectively. However, we did not observe any difference in the frequency of the resistant isolates belonging to the VK210 subtypes. MAIN CONCLUSION The VK210 variant is the most frequently observed in the studied region and there is significant genetic variability in the CRR of the P. vivax CSP. Moreover, the antimalarial drug sensitivity profiles of the isolates does not seem to be related to the VK210 subtypes.

https://doi.org/10.1590/0074-02760190054 912 downloads

Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period
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SANTOS, DAIANE S. DOS

; BOITO, JHONATAN P.

; KLAUCK, VANDERLEI

; REIS, JOÃO H. DOS

; GEBERT, ROGER R.

; GLOMBOWSKY, PATRÍCIA

; BIAZUS, ANGELISA H.

; BOTTARI, NATHIELI B.

; SOUSA, REJANE S.

; MACHADO, GUSTAVO

; LEAL, MARTA L.R.

; BALDISSERA, MATHEUS D.

; BERWANGER, JEAN C.

; SILVA, ALEKSANDRO S. DA

Anais da Academia Brasileira de Ciências

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2019, Volume 91 N. 1 elocation e20171042

Abstract: En | Text: En | PDF: En

Abstract: The aims of this study were to investigate whether treatments with zinc edetate (Zn) and diphenyl diselenide ((PhSe)2) enhance performance, immune responses, protein metabolism, and oxidant/antioxidant status in calf serum and muscle. Animals were divided into four groups (n=6 each): control (without supplementation), and groups supplemented on days 50 and 70 of life with (PhSe)2, Zn, and a combination of (PhSe)2 and Zn. Animals treated with (PhSe)2 gained more weight by experimental day 220 than did the control group, but there was no difference by the end of the experiment (day 300). The absolute number of leukocytes and lymphocytes increased in groups Zn and (PhSe)2+Zn on day 20 of experiment, but decreased on day 40 in groups (PhSe)2, and (PhSe)2+Zn. The number of monocytes decreased in all groups compared with control. One of the principal findings was that (PhSe)2+Zn together had beneficial effects on protein metabolism, represented by increases total protein and globulin levels, compared with the control group. The combination of (PhSe)2 and Zn led to low levels of TBARS and ROS in serum and muscle, and stimulated antioxidant enzyme activities. Thus, supplementation with (PhSe)2+Zn may be a compelling approach to augmenting the calf antioxidant system during weaning.

https://doi.org/10.1590/0001-3765201920171042 1416 downloads

10.

Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
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Chapadense, Francesca

; Machado, Ricardo Luiz Dantas

; Ventura, Ana Maria Revorêdo da Silva

; Áreas, André

; Machado, Renato Beilner

; Viana, Giselle Rachid

; Zalis, Mariano Gustavo

; Castro, Ana Maria de

; Cravo, Pedro

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180225

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. CONCLUSIONS: Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.

https://doi.org/10.1590/0037-8682-0225-2018 1502 downloads

11.

Levels of shading and application of glyphosate and carfentrazone-ethyl in the control of Macroptilium atropurpureum
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Costa, Gustavo A.

; Santos, Leonardo D. T.

; Ferreira, Guilherme A. de P.

; Cruz, Leandro R. da

; Machado, Vitor D.

; Rocha, Leonardo M.

Revista Brasileira de Engenharia Agrícola e Ambiental

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dec 2018, Volume 22 N. 12 Pages 819 - 824

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Variações nas condições ambientais, como a disponibilidade luminosa, podem afetar a eficiência de controle dos herbicidas por alterar características biológicas das plantas relacionadas à sensibilidade aos herbicidas. Desse modo, objetivou-se avaliar a influência do cultivo em ambientes com diferentes disponibilidades luminosas e da aplicação isolada ou em mistura de glifosato e carfentrazone-etil, sobre a morfofisiologia e o controle de M. atropurpureum. O delineamento adotado foi o de blocos casualizados, em esquema de parcelas subdivididas com 5 repetições. As parcelas foram constituídas de três níveis de sombreamento (pleno sol, 50 e 70% de sombra) e as subparcelas de dois herbicidas (glifosato e carfentrazone-etil) combinados ou não. As doses de glifosato + carfentrazone-etil utilizadas foram 0+40 g ha-1 de carfentrazone-etil, 1,440+0 g ha-1 de glifosato, 1,080+30 g ha-1 de glifosato + carfentrazone-etil e mais um tratamento sem aplicação de herbicida. Plantas de M. atropurpureum cultivadas sob sombreamento apresentaram maior sensibilidade aos herbicidas, maior área dos folíolos e menor taxa fotossintética em comparação ao seu cultivo em ambiente a pleno sol. Em sombreamento, tanto os herbicidas aplicados isoladamente quanto a mistura são efetivos no controle do M. atropurpureum, o que indica maior susceptibilidade dessa espécie aos herbicidas em ambientes com restrição luminosa. A espécie é tolerante aos dois herbicidas testados, isolados ou em mistura, quando crescida a pleno sol.

ABSTRACT Variations in environmental conditions, such as the availability of light, can affect the efficacy of herbicides because they alter the biological characteristics of plants including those that are related to the plant’s sensitivity to herbicides. Therefore, the objective of the present study was to assess the influence of environments with different light availabilities, and of the application of glyphosate and carfentrazone-ethyl (separately or in combination) on the morphophysiology and control of Macroptilium atropurpureum. An experimental design of randomized blocks with five replicates was used, with treatments arranged in a split-plot design. The plots were composed of three levels of shading (full sunlight, 50% shading, and 70% shading); within each plot there were sub-plots, one for each of the two herbicides (glyphosate and carfentrazone-ethyl), used either separately or in combination. The doses of glyphosate + carfentrazone-ethyl applied in the treatments were 0+40 g ha-1 of carfentrazone-ethyl, 1.440+0 g ha-1 of glyphosate, 1.080+30 g ha-1 of glyphosate + carfentrazone-ethyl, and there was an additional treatment that did not include the application of an herbicide. Plants of M. atropurpureum cultivated under shading exhibited higher sensitivity to the herbicides, greater leaflet area, and lower photosynthetic rates than plants cultivated under full sunlight conditions. Under shading, both herbicides applied separately or in combination were effective in controlling M. atropurpureum, which indicates a greater susceptibility of this species to these herbicides in environments with light restriction. The species was tolerant to the two tested herbicides, used either alone or in combination, when grown under full sunlight conditions.

https://doi.org/10.1590/1807-1929/agriambi.v22n12p819-824 787 downloads

12.

Insecticidal and repellent effect of cinnamon oil on flies associated with livestock
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Boito, Jhonatan P.

; Da Silva, Aleksandro S.

; dos Reis, João H.

; Santos, Daiane S.

; Gebert, Roger R.

; Biazus, Angelisa H.

; Santos, Roberto C.V.

; Quatrin, Priscilla M.

; Ourique4, Aline F

; Boligon, Aline A.

; Baretta, Dilmar

; Baldissera, Matheus D.

; Stefani, Lenita M.

; Machado, Gustavo

Revista MVZ Córdoba

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aug 2018, Volume 23 N. 2 Pages 6628 - 6636

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Objetivo. Debido a la mayor resistencia parásita, hay una necesidad de explorar insecticidas alternativos, incluidos los productos naturales, tales como aceites esenciales. En este sentido, el objetivo de este estudio fue evaluar, para el primer equipo, el efecto insecticida y repelente de Cinnamomum zeylanicum (formas libres y nanoemulsión) in vitro e in vivo. Materiales y métodos. Para ello, el efecto insecticida de la forma libre se ensayó a 1.0, 5.0 y 10%, mientras que la forma nanoemulsión se ensayó a 0.5, 1.0 y 5.0% frente a las moscas domésticas adultas, Musca domestica. Para la validación de la prueba, las moscas fueron rociados con el diluyente (agua y triton 10%) y con nanoemulsión en blanco (sin aceite esencial de C. zeylanicum). También, fueron realizados pruebas in vivo usando vacas naturalmente infestadas con Haemotobia irritans. Resultados. Los resultados demostraron que el aceite de canela (10%) y la nanoemulsión (5%) fueron 100% eficaz contra M. domestica después de 90 minutos de exposición. El efecto repelente se ensayó in vivo usando 5% de aceite de canela en vacas Holstein, naturalmente infestados por Haemotobia irritans. Se contaron las moscas a las 0, 1, 2, 3, 9 y 24 h después del tratamiento el aceite de canela. Se verificó disminución significativa (p<0.05) en el número de moscas vivas de vacas canela pulverizada en todo momento. Conclusiones. En base a estos resultados, C. zeylanicum mostró un efecto insecticida (in vitro) contra las moscas domésticas y efecto repelente (in vivo) contra la mosca de los cuernos.

Abstract Objective. Due to the increased parasitic resistance, there is a need to explore alternative insecticides, including natural products, such essential oils. In this sense, the aim of this study was to evaluate, for the first time, the insecticidal and repellent effect of Cinnamomun zeylanicum (free and nanoemulsion forms) in vitro and in vivo. Materials and methods. For that, the insecticidal effect of the free form was tested at 1.0, 5.0 and 10%, while the nanoemulsion form was tested at 0.5, 1.0 and 5.0% against adult house flies, Musca domestica. For validation of the test, the flies were sprayed with the diluent (water and triton 10%) and with blank nanoemulsion (without C. zeylanicum essential oil). Moreover, in vivo test was performed using cows naturally infested with Haemotobia irritans. Results. The results demonstrated that cinnamon oil (10%) and the nanoemulsion (5%) were 100% effective against M. domestica after 90 minutes of exposure. The repellent effect was tested in vivo using 5% of cinnamon oil on Holstein cows naturally infested by Haemotobia irritans. The flies were counted at 0, 1, 2, 3, 9 and 24 h after cinnamon oil treatment. It was verified significant decrease (p<0.05) in the number of flies on cows sprayed with cinnamon in all times. Conclusions. Based on these results, C. zeylanicum showed insecticidal effect (in vitro) against domestic flies and repellent effect (in vivo) against the horn fly.

https://doi.org/10.21897/rmvz.1337 1534 downloads

13.

Detection of Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli in Brazilian mastitic milk goats by multiplex-PCR
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Machado, Gustavo P.

; Silva, Rodrigo C.

; Guimarães, Felipe F.

; Salina, Anelise

; Langoni, Hélio

Pesquisa Veterinária Brasileira

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jul 2018, Volume 38 N. 7 Pages 1358 - 1364

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este estudo avaliou por multiplex-PCR a prevalência de Staphylococcus aureus, Streptococcus agalactiae e Escherichia coli em amostras de leite de 257 caprinos (513 tetos) e dez tanques de expansão, em dez fazendas leiteiras do estado de São Paulo, Brasil. As amostras foram triadas por cultura microbiológica (padrão-uro) e testadas por diferentes protocolos multiplex-PCR para a detecção de cada bactéria. Um total de 178 amostras de leite foram positivos na cultura microbiológica, com estafilococos coagulase-negativos (70%), S. aureus (13,5%), S. intermedius (7,9%) e Enterobacteriaceae (4%) como patógenos prevalentes. Por outro lado, a PCR multiplex detectou 173 patógenos em 151/523 (28,9%, IC95% 25,2-32,9%) amostras de leite, 144/513 (28,1%) amostras de tetos e 7/10 (70%) em tanques de expansão, E. coli (86/162, 51,9%) e S. aureus (50/162, 30,9%) foram identificados nas amostras de tetos e S. aureus (6/10, 60%) e E. coli (4/5, 36,4%) em tanques expansão. Multiplex-PCR mostrou um alto desempenho para a detecção das três bactérias em leite de cabra com mastite ou em tanques de expansão. Dessa forma, este protocolo multiplex-PCR provou ser uma ferramenta adequada para a identificação dos patógenos mais comuns da mastite, independentemente de suas características fenotípicas no diagnóstico de mastite clínica em caprinos, permitindo uma vigilância contínua e melhor acompanhamento do rebanho, sendo incluído em programas de qualidade.

ABSTRACT: This study evalueted the prevalence of Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli in milk samples from 257 goats (513 half-udders) and ten bulk tanks, from ten dairy goat farms of São Paulo State, Brazil, by multiplex-PCR. The samples were screened by microbiological culture (gold-standard), and tested by different multiplex-PCR protocols for the detection of each bacterium. A total of 178 half-udders resulted positive by microbiological culture, with coagulase-negative staphylococci (70%), S. aureus (13.5%), S. intermedius (7.9%), and Enterobacteriaceae (4%) the prevalent pathogens. In other way, multiplex-PCR detected 173 pathogens in 151/523 (28.9%; CI95% 25.2-32.9%) milk samples 144/513 (28.1%) half-udders and 7/10 (70%) bulk tanks, with E. coli (86/162, 51.9%) and S. aureus (50/162, 30.9%) the prevalent ones in half-udders, and S. aureus (6/10, 60%) and E. coli (4/5, 36.4%) in bulk tanks. Multiplex-PCR showed a high performance for the detection of three bacteria at a time in mastitic goat milk direct from half-udders or bulk tanks. Thus, this multiplex-PCR protocol proved to be an adequate tool for the identification of the most common mastitis pathogens, independent of their phenotypic characteristics in the diagnosis of clinical mastitis in goats, allowing a continuous and better vigilance and monitoring the herd, being included in quality programs.

https://doi.org/10.1590/1678-5150-pvb-55141 1265 downloads

14.

Injectable diphenyl diselenide supplementation in dairy sheep
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Biazus, Angeliza H

; Cazarotto, Chrystian J

; Gebert, Roger R

; Reis, João H. dos

; Zortea, Talyta

; Baretta, Dilmar

; Machado, Gustavo

; Boito,, Jhonatan P.

; Baldissera,, Matheus D.

; Silva, Aleksandro S da

Revista MVZ Córdoba

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apr 2018, Volume 23 N. 1 Pages 6438 - 6447

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Objetivo. El objetivo de este estudio fue evaluar la influencia de la suplementación subcutánea con diselenuro de difenilo (PhSe)2 en ovejas lecheras infectadas con nematodos sobre la salud animal y posible daño al ambiente cuando las heces de estos animales se utilicen para fertilizar. Materiales y métodos. El experimento se realizó utilizando 16 ovejas lecheras, que se dividieron en dos grupos: el grupo A se usó como control y el grupo B se suplementó con 3 µmol/kg of (PhSe)2 vía subcutánea. Se utilizaron muestras de sangre para determinar la función hepática, así como el metabolismo de proteínas y lípidos en animales. Las heces se utilizaron para determinar el número de huevos por gramo de heces (EPG), así como para las pruebas de ecotoxicología. Resultados . La suplementación (PhSe)2 no afectó la reproducción de helmintos. Los niveles totales de proteína y globulina aumentan (p<0.05) en los animales suplementados, mientras que los niveles séricos de alanina aminotransferasa (ALT) disminuyen (p<0.05) al final del diseño experimental. Los niveles de colesterol aumentan (p<0.05) en los animales suplementados, mientras que los triglicéridos, la albúmina y la urea no difieren entre los grupos (p>0.05). Las heces de ovejas suplementadas no interferían en la reproducción de las colas de caballo. Conclusiones. A la dosis administrada, el (PhSe)2 no es capaz de controlar el parasitismo; sin embargo, aumenta los niveles de globulinas y colesterol, que son importantes para la respuesta inmune y para la reproducción, respectivamente. Las heces de animales suplementados pueden usarse como fertilizantes orgánicos, sin impactos negativos en ambiente.

ABSTRACT Objective. The aim of this study was to evaluate the influence of subcutaneous supplementation with diphenyl diselenide ((PhSe)2) in dairy sheep infected with gastrointestinal nematodes on animal health and possible damage to environment when the feces of these animals will be used for fertilizing. Materials and methods. The experiment was performed using 16 primipara dairy sheep, that were divided into two groups: the group A as control and the group B supplemented with 3 µmol/kg of (PhSe)2 subcutaneously. Blood samples were used to determine the hepatic function, as well as the protein and lipid metabolism in animals. Feces were used to determine the number of helminths eggs per gram of feces (EPG), as well as used for ecotoxicology tests. Results. The (PhSe)2 supplementation not affected the helminths reproduction, since the EPG did not differ (p>0.05) between groups. Total protein and globulin levels increase (p<0.05) in supplemented animals, while the seric alanine aminotransferase (ALT) levels decrease (p<0.05) in the end of experimental design. Cholesterol levels increase (p<0.05) in the supplemented animals, while triglycerides, albumin and urea not differ between groups (p>0.05). The feces of supplemented sheep not interfered the springtails reproduction. Conclusions. At the administered dose, the (PhSe)2 is not able to control the parasitism, however, it did increase the globulins and cholesterol levels, that are important to immune response and for sheep reproduction, respectively. Also, the feces of supplemented animals with (PhSe)2 can be used as organic fertilizing, without negative impacts to environment.

https://doi.org/10.21897/rmvz.1239 274 downloads

15.

Influence of visual field results in the glaucoma diagnosis
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Magacho, Leopoldo

; Franco, Cláudia Gomide Vilela de Sousa

; Figueiredo, Gustavo de Paula

; Vale, Arnaldo Machado Borges do

; Rassi, Bruna Thomé

; Ávila, Marcos P.

Revista Brasileira de Oftalmologia

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dec 2017, Volume 76 N. 6 Pages 285 - 288

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Avaliar a influência da campimetria computadorizada no diagnóstico do glaucoma. Métodos: Foi realizado questionário com oftalmologistas apresentando slides com uma fotografia digital de disco óptico e campo visual computadorizado. Os médicos deveriam assinalar se o exames apresentados eram de glaucoma ou não. Nenhuma outra informação foi passada para os examinadores. Metade dos pacientes apresentavam glaucoma com dano correspondente de campo visual, e a outra metade aumento fisiológico da escavação e campo visual normal. Os slides foram igualmente divididos em: retinografia e campo visual correspondentes (mesmo paciente) e exames invertidos de forma aleatória, colocando um disco óptico de glaucoma com um campo visual normal e vice-versa. A ordem de apresentação dos slides foi randomizada previamente. Resultados: Foram incluídos 40 slides, avaliados por 29 oftalmologistas. Nenhum especialista em glaucoma foi incluído. A concordância entre os examinadores (Kappa) foi de 0,270 ± 0,281, sendo de 0,261 ± 0,238 para os exames correspondentes e 0,274 ± 0,217 para os slides com os exames trocados (p=0,4). O diagnóstico foi realizado corretamente nos pacientes com glaucoma com o campo visual correspondente em 66,89% dos casos, e em 66,20% nos pacientes com aumento da escavação (normais). Quando houve a troca da correspondência dos exames, os valores caíram para 34,13% e 35,86%, respectivamente (p<0,001 para ambos). Conclusão: O conhecimento prévio dos resultados do campo visual pode influenciar o diagnóstico do glaucoma.

Abstract Objective: To determine the influence of visual field results in the diagnosis of glaucoma. Methods: A questionnaire with ophthalmologists was conducted where slides of a digital photograph of the optic disc and computerized visual field exam were presented.(Physicians were instructed to answer whether glaucoma was observed in each of the slides). No other information was given to those examiners. Half of the patients had glaucoma with corresponding visual field, and the other half had physiological cupping and normal visual field. The slides were equally divided between retinography and corresponding visual field (same patient) and exams randomly exchanged, where an optic disc of glaucoma with a normal visual field was placed, and vice-versa. The order in which the slides were presented was also randomized. Results: Forty slides were evaluated by 29 ophthalmologists. No glaucoma specialist was included. The overall agreement among the examiners (Kappa) was 0.270 ± 0.281, and 0.261 ± 0.238 for the exams of the same eye and was 0.274 ± 0.217 from the slides with the exams changed (p=0.4). The diagnosis was made correctly in glaucoma patients with corresponding visual field exam in 66.89% of the cases, and in 66.20% of patients with physiological cupping. When the exams were exchanged, the results dropped to 34.13% and 35.86%, respectively (p<0.001 for both). Conclusion: Visual field results may influence the diagnosis of glaucoma by non-glaucoma specialists.

https://doi.org/10.5935/0034-7280.20170059 692 downloads

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