Resumen Introducción: Existen dos formas de presentación clínica de los síndromes coronarios agudos (SCA): con elevación del segmento ST (SCACEST) y sin elevación (SCASEST). Los mecanismos que determi nan ambas presentaciones no se conocen completamente. El objetivo del estudio fue definir la asociación entre factores de riesgo cardiovascular y otras variables clínicas con la presentación de los SCA como SCACEST o SCASEST. Métodos: Analizamos información de pacientes incluidos prospectivamente en el Registro Epi-Cardio con diagnóstico de SCA desde abril de 2006 a abril de 2018.Se incluyeron un total de 10 019 pacientes. Resul tados: En el análisis multivariado, el sexo masculino (OR 1.5) y el tabaquismo activo (OR 1.71) se asociaron positivamente con el SCACEST. Contrariamente, la hipertensión (OR 0.71), las dislipidemias (OR 0.74), la edad (OR 0.97 por quintilo), historia de infarto (OR 0.57), angina crónica (OR 0.44), presencia de comorbilidades (OR 0.64), y la extensión de enfermedad coronaria (OR 0.84) se asociaron negativamente con el SCACEST. Las mujeres presentaron mayor incidencia de SCASEST, debido a una mayor proporción de SCA sin obstrucción coronaria significativa. Conclusión: Concluimos que algunos factores de riesgo cardiovascular y otras variables clínicas se asociaron independientemente con la presentación clínica como SCACEST o SCASEST, confirmando su influencia en la fisiopatología y en la presentación clínica y electrocardiográfica de los SCA.

Abstract Introduction: Two clinical presentations of acute coronary syndrome (ACS) have been defined: ST- segment elevation ACS (STEACS) or non-ST-segment elevation ACS (NSTEACS). The mecha nism that determines the clinical presentation of ACS is not clearly understood. The aim of this study was to define the association between cardiovascular risk factors and other clinical variables with the clinical presentation of ACS as STEACS or NSTEACS. Methods: We analyzed data of patients prospectively included in the Epi-Cardio Registry with a diagnosis of ACS from April 2006 to April 2018. A total of 10 019 patients were included in the study. Results: In the multivariate analysis, male sex (OR 1.5) and active smoking (OR 1.71) were positively associated with STEACS presentation. Conversely, hypertension (OR 0.71), dyslipidemia (OR 0.74), age (OR 0.97 per quintile), history of myocardial infarction (OR 0.57), chronic angina (OR 0.44), presence of comorbidities (OR 0.64), and extension of coronary heart disease (OR 0.84) were negatively associated with STEACS. Women differed from men by presenting a higher incidence of NSTEACS, due to a greater proportion of ACS without obstructive coronary heart disease. Conclusion: Some cardiovascular risk factors and other clinical variables are independently associated with the presentation of ACS as ST EACS or NSTEACS. These findings confirm the influence of risk factors and clinical history on the pathophysiology, clinical and electrocardiographic presentation of ACS.

Chagas disease, caused by the parasite Trypanosoma cruzi, occurs most commonly in Latin America. As the treatment is highly toxic and ineffective in the chronic phase of the disease, alternative treatments are needed. Through quantitative structure-activity relationship modeling (QSAR) analysis using ligand-based and structure-based virtual screening methods, we predicted the trypanocidal potential of 47 neolignans against three targets, the enzymes cruzain, trypanothione reductase, and sterol 14-alpha demethylase. A combined analysis allowed for the selection of potent inhibitors against Trypanosoma cruzi. Of these compounds, two were isolated and shown to inhibit the growth of epimastigotes at concentrations of 9.64 and 8.72 µM, and trypomastigote forms at 4.88 and 2.73 µM. Therefore, the compounds (2R, 3R)-2,3-dihydro-2 (4 methoxyphenyl)-3-methyl-5-(E)-propenylbenzofuran (46) and ottomentosa (47) may be a good option of growth inhibitors for the parasite stages and warrant additional study.

RESUMEN El aumento del área agrícola en el norte de la provincia de Entre Ríos resulta de la pérdida del bosque nativo. Este cambio del uso del suelo impacta los servicios ecosistémicos que brindan las cuencas hidrográficas, e incrementa el riesgo de degradación y pérdida de suelo por erosión. Actualmente el límite de pérdida de suelo utilizado para diseñar prácticas de sistematización de tierras es 15 Mg.ha-1.año-1, valor tres veces mayor al umbral para una producción sustentable. Este trabajo relaciona la cartografía de variables hidrológicas y pérdida de suelos para localizar y caracterizar áreas vulnerables a la erosión hídrica, como herramientas de ordenamiento territorial de cuencas. Se usaron los parámetros de curva número (CN), índice topográfico (TCI) y la ecuación USLE. Se trabajó en un entorno SIG en la cuenca del A° Estacas, con resolución espacial de 30 metros. Las imágenes fueron referenciadas al sistema POSGAR 2007 - FAJA 5. Como datos de entrada se utilizó: MDE ALOS PALSAR, carta de suelos de la provincia a escala 1:100.000, precipitación media anual, e imágenes Landsat 8. Se realizaron estadísticas por composición de mapas, gráficos de densidad por Kernel y ajuste por estimadores de máxima verosimilitud. Se observó que la pérdida de suelo se incrementa directamente con la generación de escurrimiento (CN), e inversamente con la probabilidad de encharcamiento (TCI). La cartografía generada verificó que reducir el umbral de pérdida de suelo a 3 Mg.ha-1.año-1 es factible como límite para una producción sustentable en la cuenca, independientemente del uso de suelo. Se definieron sectores que requieren una rápida acción correctiva, donde las pérdidas de suelo superan las 15 Mg.ha-1.año-1. Además, se identificaron áreas vulnerables entre 5 y 15 Mg.ha-1.año-1, tanto bajo uso agrícola como ganadero, donde se necesita revisar la intervención.

ABSTRACT Expansion of agricultural land use in the north of Entre Ríos province diminishes land occupied by native forests. At watershed scale, this change in land use impacts the provision of ecosystem services and in-creases soil´s degradation and water erosion. Current limit of soil loss for design of terraces is 15 Mg.ha-1. yr-1, three times larger than FAO threshold for sustainable agricultural production. In this work the mapping of hydrological variables and soil loss is combined to determine and characterize vulnerable areas to soil water erosion, as tools for watershed land use planning. The parameters of curve number (CN), topographic index (TCI) and the USLE equation were used. Work was carried out in a GIS environment in the A° Estacas watershed, with a spatial resolution of 30 meters. The images were referenced to the POSGAR 2007 - FAJA 5 system. The input data used were: ALOS PALSAR DEM, soil map of the province at a scale of 1:100,000, average annual precipitation, and Landsat 8 images. Statistical methods included univariate analyses, Kernel density distribution, and máximum likelihood. Soil loss increased directly with runoff generation (CN), and inversely with the probability of waterlogging (TCI). The generated mapping verified that regardless of land use, it is feasible to reduce the soil loss threshold for sustainable production in the basin to 3 Mg.ha-1. yr-1. The proposed mapping defined areas requiring rapid corrective actions, where estimated soil losses exceeded 15 Mg.ha-1.yr-1. In addition, the mapping allowed to localize vulnerable areas within the watershed, with soil loss between 5 and 15 Mg.ha-1.yr-1, under agricultural and livestock use, where their intervention should be reviewed.

Abstract Cancer patients are exposed to more complications from COVID-19 than non-cancer patients. We report a cohort of 74 cancer patients (87.8% with solid neoplasia and 12.2% with hematological diseases) with COVID-19 infection admitted to a tertiary medical cancer center in Argentina. Pulmonary infiltrates were diagnosed at admission in 78.3% (N = 58) of the cases. COVID-19 infection was hospital-acquired in 20 (27.0%) patients. Thirty-nine patients (52.7%) received anticancer therapy within the 30 days prior to COVID-19 diagnosis; one was on radiation therapy. Twenty-four (32.4%) patients were admitted in the intensive care unit (ICU) and 18 (75.0%) required mechanical ventilation. All cause in-hospital mortality was 32.4% (N = 24) and ICU mortality was 62.5% (N = 15). Mortality under me chanical ventilation was 72.2% (N = 13). In the univariate analysis age, neutrophil count, neutrophil/lymphocyte index, D-dimer, ferritin, smoking, and nosocomial acquired infection were associated with in-hospital mortality. There were no statistically significant differences in mortality related to disease stage for solid tumors, neither cancer treatment within 30 days of COVID-19 diagnosis. Age and smoking were associated with mortality in the multivariate analysis. The adjusted odds ratios (95 CI) for age ≥ 65 years and smoking were 8.87 (1.35-58.02) and 8.64 (1.32 - 56.64), respectively. Our experience can be useful for other institutions that assist cancer patients during the pandemic.

Resumen Los pacientes con cáncer y COVID-19 tienen más complicaciones que la población general. Comunicamos una cohorte de 74 pacientes con cáncer y COVID-19 internados en una institución on cológica. El 87.8% tenía diagnóstico de tumores sólidos y 12.2% oncohematológicos. Entre los tumores sólidos, el 61.5% presentó enfermedad metastásica. El 78.3% (N = 58) tenía infiltrados pulmonares al diagnóstico de COVID-19. La infección fue intrahospitalaria en 20 pacientes. Habían recibido tratamiento antineoplásico den tro de los 30 días anteriores al diagnóstico 39 pacientes (52.7%); uno se encontraba recibiendo radioterapia. Veinticuatro pacientes (32.4%) se derivaron a terapia intensiva (UTI) y 18 (75%) de ellos requirieron asistencia respiratoria mecánica (ARM). La mortalidad general durante la internación fue 32.4% (N = 24). La mortalidad en UTI fue 62.5% (N = 15). La mortalidad en ARM fue 72.2% (N = 13). La edad, recuento de neutrófilos, índice neutrófilo/linfocito, dímero D, ferritina, tabaquismo y haber adquirido la infección durante la internación resultaron estadísticamente significativos en el análisis univariado para mortalidad. No hallamos diferencias en mortalidad por estadio de enfermedad, en los pacientes con tumores sólidos, ni por haber recibido tratamiento antineoplá sico dentro de los 30 días del diagnóstico de COVID-19. En el análisis multivariado con el modelo de regresión logística, solo la edad y el tabaquismo fueron predictores de mortalidad. Los odds ratios (IC 95) ajustados para la edad ≥65 años y el tabaquismo fueron 8.87 (1.35-58.02) y 8.64 (1.32-56.64), respectivamente. Este trabajo puede resultar de utilidad para instituciones polivalentes que asistan pacientes oncológicos durante la pandemia.

Abstract Introduction: The Technical Performance Score (TPS) was developed and subsequently refined at the Boston Children's Hospital. Our objective was to translate and validate its application in a developing country. Methods: The score was translated into the Portuguese language and approved by the TPS authors. Subsequently, we studied 1,030 surgeries from June 2018 to October 2020. TPS could not be assigned in 58 surgeries, and these were excluded. Surgical risk score was evaluated using Risk Adjustment in Congenital Heart Surgery (or RACHS-1). The impact of TPS on outcomes was studied using multivariable linear and logistic regression adjusting for important perioperative covariates. Results: Median age and weight were 2.2 (interquartile range [IQR] = 0.5-13) years and 10.8 (IQR = 5.6-40) kilograms, respectively. In-hospital mortality was 6.58% (n=64), and postoperative complications occurred in 19.7% (n=192) of the cases. TPS was categorized as 1 in 359 cases (37%), 2 in 464 (47.7%), and 3 in 149 (15.3%). Multivariable analysis identified TPS class 3 as a predictor of longer hospital stay (coefficient: 6.6; standard error: 2.2; P=0.003), higher number of complications (odds ratio [OR]: 1.84; 95% confidence interval [CI]: 1.1-3; P=0.01), and higher mortality (OR: 3.2; 95% CI: 1.4-7; P=0.004). Conclusion: TPS translated into the Portuguese language was validated and showed to be able to predict higher mortality, complication rate, and prolonged postoperative hospital stay in a high-volume Latin-American congenital heart surgery program. TPS is generalizable and can be used as an outcome assessment tool in resource diverse settings.

Abstract Introduction: Elevated neutrophil-lymphocyte ratio (NLR) has been associated with poorer outcomes in cyanotic patients undergoing single ventricle palliation. Little is known about this biomarker on patients with tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. Our objective is to study the impact of preoperative NLR on outcomes of TOF patients undergoing total repair. Methods: This retrospective study included 116 consecutive patients between January 2014 and December 2018. Preoperative NLR was measured from the last complete blood count test before the surgery. Using the cutoff value of 0.80, according to the receiver-operating characteristic (ROC) curve, the sample was divided into two groups (NLR < 0.80 and ≥ 0.80). The primary endpoint was hospital length of stay (LOS). Results: ROC curves showed that higher preoperative NLR was associated with longer hospital LOS, with an area under the curve of 0.801±0.040 (95% confidence interval 0.722 - 0.879; P<0.001). High preoperative NLR was also associated with long intensive care unit (ICU) LOS (P=0.035). Preoperative NLR predicted longer hospital LOS with a sensitivity of 63% and a specificity of 81.4%. Conclusion: Higher preoperative NLR was associated with long ICU and hospital LOS in patients undergoing TOF repair.

Abstract The management of patients with immune-related adverse events (irAEs) frequently demands a multidisciplinary approach. We reviewed the causes and clinical course of medical visits and admissions at the Instituto Alexander Fleming due to irAEs between September 2015 and July 2019. Demographic data, diagnosis, toxicity and its severity, requirement of admission, treatment, mortality, and evaluation of the re-administration of immunotherapy were collected. We found 124 irAEs in 89 patients. Sixty-eight of them received monotherapy (76.4%) and 21 (23.6%) combination of drugs. Cutaneous manifestations were the most frequent cause of irAEs, followed by general manifestations, endocrine dysfunctions (hypothyroidism the most frequent), colitis, pneumonitis, neurologic dis orders, and hepatitis. In 26 adverse events (in 25 patients), severity grade was ≥ 3. Fifteen were admitted and 6 required ICU admission. One patient died. Thirty-four received glucocorticoids, 12 of them by intravenous route. One patient received mycophenolate and one IVIG. In 20, the treatment was discontinued; 8 were re-exposed, with definitive discontinuation in one patient. In this case series we report our experience in the diagnosis and management of adverse reactions related to a family of drugs whose use has grown in recent years.

Resumen El manejo de las reacciones adversas inducidas por los inhibidores del punto de control inmunitario (IPCI) en cáncer, demanda un trabajo multidisciplinario. Revisamos las causas y el curso clínico de las consultas e internaciones debidas a reacciones adversas de los IPCI entre septiembre de 2015 y julio de 2019 en el Instituto Alexander Fleming. Se registraron los datos demográficos, diagnóstico oncológico, reacción adversa y su grado, requerimiento de internación, tratamiento, mortalidad y evaluación de la reexposición. Se registraron 124 reacciones adversas por IPCI en 89 pacientes. Sesenta y ocho recibían monoterapia y 21 terapia combinada. Las manifestaciones cutáneas fueron las más frecuentes, seguidas de las generales, endocrinas (con mayor frecuencia hipotiroidismo), colitis, neumonitis, neurológicas y hepatitis. Fueron graves (grado ≥ 3), 26 toxicidades en 25 pacientes. Se internaron 15, y 6 de ellos requirieron terapia intensiva. Un caso fue fatal. Recibieron glucocorticoides 34 (12 de ellos por vía intravenosa). Un paciente recibió micofenolato y uno inmuno globulina endovenosa. En 20 se discontinuó el tratamiento. Ocho se reexpusieron y uno de ellos debió suspender definitivamente. Se presenta en esta serie de casos nuestra experiencia con el diagnóstico y tratamiento de las reacciones adversas de una familia de drogas cuya utilización ha crecido en los últimos años.

Resumo Este estudo teve como objetivo determinar a co-soropositividade para agentes transmitidos por carrapatos, como Anaplasma marginale, Babesia bovis, Babesia bigemina, Coxiella burnetii, Anaplasma phagocytophilum, e Trypanosoma vivax em bovinos de corte do Pantanal Brasileiro. Amostras de soro foram colhidas de 400 animais (200 vacas; 200 bezerros) e submetidas a Ensaios Imunoenzimáticos Indiretos (iELISA) para detecção de anticorpos IgG anti- A. marginale, anti- B. bovis, anti- B. bigemina e anti- T. vivax, e à Reação de Imunofluorescência Indireta (RIFI) para detecção de anticorpos IgG anti -C. burnetii e anti- A. phagocytophilum. Ausência de correlação foi vista entre os animais soropositivos para C. burnetii e A. phagocytophilum com os outros agentes e correlação moderada ocorreu entre A. marginale x B. bigemina x B. bovis. Vacas foram mais soropositivas que bezerros para T. vivax e bezerros mais soropositivos que vacas para B. bovis e B. bigemina. Maior número de animais soropositivos para um único agente foi visto para T. vivax (15,2%). Vacas demonstraram maior co-soropositividade para T. vivax + A. marginale (25,5%) e bezerros para T. vivax + B. bovis + B. bigemina + A. marginale (57,5%). A alta correlação entre a soropositividade para A. marginale x B. bovis x B. bigemina é provavelmente devida à presença do vetor biológico, o carrapato Rhipicephalus microplus, nas fazendas estudadas. As vias de transmissão comuns, mediadas por dípteros hematófagos e fômites, podem explicar a alta co-soropositividade das vacas para A. marginale e T. vivax. A baixa soropositividade para C. burnetii é provavelmente devida ao tipo de sistema de criação empregado (extenso). A soropositividade para A. phagocytophilum em apenas um animal sugere a ocorrência de reação sorológica cruzada com outro agente do gênero Anaplasma.

Abstract This study investigated the seropositivity for five different tick-borne agents, namely Anaplasma marginale, Babesia bovis, Babesia bigemina, Coxiella burnetii, Anaplasma phagocytophilum, and Trypanosoma vivax in beef cattle in the Brazilian Pantanal. The serum samples collected from animals (200 cows; 200 calves) were used in indirect enzyme-linked immunosorbent assays (iELISA) to detect IgG antibodies against A. marginale, B. bovis, B. bigemina, and T. vivax, and Indirect Fluorescent Antibody Test (IFAT) for detecting IgG antibodies against C. burnetii and A. phagocytophilum. No correlation was observed between seropositivity for C. burnetii and A. phagocytophilum with other agents whereas moderate correlation was observed for A. marginalexB. bigemina x B. bovis. Cows were more seropositive for T. vivax whereas calves were more seropositive for B. bovis and B. bigemina. The highest number of seropositive animals by a single agent was observed for T. vivax (15.2%). Co-seropositivity for T. vivax + A. marginale was higher in cows (25.5%) and for T. vivax + B. bovis + B. bigemina + A. marginale was higher in calves (57.5%). The high seropositivity correlation for A. marginale x B. bovis x B. bigemina is probably due to the presence of the tick biological vector, Rhipicephalus microplus, in the studied farms. Common transmission pathways, mediated by hematophagous dipterans and fomites, may explain the high co-seropositivity of cows for A. marginale and T. vivax. Low seropositivity to C. burnetii is probably due to the type of breeding system employed (extensive). Seropositivity for A. phagocytophilum in only one animal suggests the occurrence of a cross-serological reaction with another agent of the genus Anaplasma.

RESUMO: Avaliou-se neste estudo a atividade antimicrobiana e a toxicidades aguda e crônica do extrato da entrecasca de Stryphnodendron adstringens. A partir do extrato seco, obtido através da maceração estática da casca do caule em etanol de cereais, foi realizada a quantificação de taninos totais (32,7%) pelo método de Folin-Denis. A atividade antimicrobiana do extrato seco extraído de cascas do caule de S. adstringens foi avaliada pela técnica de disco-difusão para os micro-organismos Escherichia coli (ATCC 25922) e Staphylococcus aureus (ATCC 25923) nas concentrações de 200, 400 e 600μL/mL. Os testes de concentração inibitória mínima revelaram que 600μL/mL inibiu o crescimento dos dois micro-organismos testados; o mesmo resultado foi observado para atividade bactericida na concentração de 600μL/mL sobre essas espécies. Efeitos tóxicos sistêmicos agudos e crônicos do extrato seco de S. adstringens administrados por gavagem foram estudados em ratos Wistar, utilizando as doses de 400, 600 e 800mg/kg. Foi observada degeneração hepática no grupo de animais que receberam 800mg/kg tanto no estudo da toxicidade aguda quanto crônica, que pode indicar algum grau de toxicidade de S. adstringens nessa concentração. Considerando o amplo uso de S. adstringens como fitoterápico para humanos e animais, atenção deve ser dispensada para ingestão em altas doses mediante os efeitos tóxicos observados neste estudo.

ABSTRACT: This study evaluated the antimicrobial activity and acute or chronic toxicity of the extract of Stryphnodendron adstringens. The stem bark dry extract was obtained by static maceration with ethanol. Quantification of tannins was performed by the Folin-Denis method, which indicated a total tannin content of 32.7%. The antimicrobial activity of the dry extract of S. adstringens was evaluated by agar-based disk diffusion assay with Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) in the concentration of 200, 400 and 600μL/mL. The results indicated that 600μL/mL inhibited microbial growth, i.e. had antimicrobial activity against these species. Acute and chronic toxic effects of S. adstringens was evaluated in Wistar rats treated with 200, 400, 600 and 800mg/kg of extract, administrated by gavage. Liver degeneration was observed in the group of rats receiving 800mg/kg in chronic exposure, what may indicate some degree of toxicity at this concentration. However, no systemic toxicity was observed at lower doses. Considering the broad use of S. adstringens as a phytotherapeutic agent for various human and animal diseases and the livertoxicity observed at high concentrations, attention should be paid to the possible adverse effect of using the extract from this plant at high concentration.

RESUMO: O milho é uma cultura exigente em nitrogênio e a utilização de práticas de manejo como a inoculação das sementes com bactérias diazotróficas, poderão maximizar a produtividade da cultura, atrelados a redução do uso de adubos nitrogenados, podendo refletir em menor custo de produção. O presente trabalho objetivou avaliar o efeito da inoculação de sementes de milho com Azospirillum brasilense e adição controlada de nitrogênio em cobertura sobre a nutrição, componentes da produção e produtividade de grãos da cultura. O delineamento experimental foi o de blocos casualizados, com quatro repetições, em esquema fatorial 2 x 5. Os tratamentos foram constituídos pela inoculação ou não das sementes do milho com A. brasilense (dose de 100 mL para 25 kg de sementes) e cinco doses de nitrogênio (N) em cobertura (0, 30, 60, 90 e 120 kg N ha-1 fonte ureia [45% N]) foram aplicadas quando o milho estava no estádio fenológico V6. Teores de macronutrientes foliares, o índice de clorofila foliar (FCI), os componentes da produção e a produtividade de grãos do milho foram avaliados. Constatou-se que a inoculação das sementes de milho com A. brasilense incrementou a altura de plantas e a produtividade de grãos. A adubação em cobertura, com a dose de até 120 kg N ha-1, aumentou linearmente os teores nutricionais foliares e a produtividade de grãos do milho irrigado cultivado na primavera/verão na região de Cerrado de baixa altitude do Brasil.

ABSTRACT: Corn is a nitrogen-intensive crop, and the use of management practices such as inoculation of the seed with diazotrophic bacteria, which can maximize crop productivity and reduce the need of nitrogen fertilizers, may result in lower production costs. The present study aimed to evaluate the effect of inoculation of corn seed with Azospirillum brasilense and controlled addition of nitrogen to topdressing on the nutrition, production components, and productivity of crop grain. The experimental design was a randomized block design, with four replications in a 2 × 5 factorial scheme. The treatments consisted of inoculation or not of corn seed with A. brasilense (at 100 mL per 25 kg of seed) and five nitrogen (N) levels in topdressing (0, 30, 60, 90, and 120 kg N ha-1 from urea [45% N]) were applied when the corn was in the phenological growth stage V6. Foliar macronutrients, foliar chlorophyll index (FCI), production components, and yield of corn grain were valuated. Inoculation of corn seeds with A. brasilense increased plant height and grain yield. Fertilization in topdressing, with N levels up to 120 kg ha-1, linearly increased the foliar nutrients and productivity of corn cultivated in the spring/summer in the low-altitude Cerrado region of Brazil.

La terminología empleada para definir los depósitos clásticos relacionados con la actividad volcánica, tiene importantes implicaciones para la sociedad en regiones circundantes a volcanes. Teniendo en cuenta la importancia de un lenguaje común, que se incrementa cuando se relaciona el registro geológico con las amenazas volcánicas potenciales, y la sociedad en general, en este trabajo se presenta una clasificación integral que conecta las características de los depósitos volcaniclásticos y los fragmentos constituyentes con la formación y los procesos de sedimentación (eruptivos y no eruptivos). Esta clasificación se propone como base de referencia para la comunidad científica hispanohablante con el fin de saldar las incontables inconsistencias dadas a partir de múltiples traducciones. Adicionalmente, se presenta un diagrama de flujo tanto en español como en inglés, que ilustra el sistema de clasificación integral el cual es útil para describir y definir tanto depósitos consolidados/litificados como no consolidados. Esta clasificación es útil para ser usada tanto en definición como en comunicación de la amenaza volcánica potencial.

The terms used to define the clastic deposits related to volcanic activity have important implications for the society in volcanic regions. Taking into account the importance of using a common terminology when considering natural hazards in the Spanish-speaking world, this study presents a classification of volcaniclastic deposits. This classification attempts to integrate the terminology related to the formational and depositional processes (eruptive and non-eruptive) taking place at volcanoes with the resulting volcaniclastic deposits and their constituent components. The classification emphasizes on how both physical and temporal variations in volcanic activity are responsible for observed differences in the related deposits. The purpose of this classification is to be a reference for the Spanishspeaking scientific community in order to avoid the numerous inconsistencies derived from the existing translations from multiple authors. Additionally, we present a flow diagram in both Spanish and English to illustrate that this classification system can be used to define and classify consolidated/lithified, and unconsolidated deposits. The appropriate classification of volcaniclastic deposits and their constituents can ultimately improve the definition and communication of potential volcanic hazards.

Human beings have accumulated rich experience with natural resources over time, but such knowledge can be strongly influenced by several factors, such as age, sex and occupation. This study focuses on the influence of these factors on knowledge of medicinal plants in a rural community in northeastern Brazil. Data were collected through semi-structured interviews with 102 people, with the number of plants and uses cited studied for quantitative analysis. Through this research, it was possible to show that the social variables studied (age, sex and informants occupation) have contributed to the formation of different patterns of knowledge regarding medicinal resources. The results indicate that awareness of this dynamic is necessary for the proper implementation of projects where the goal is the sustainable use of natural resources (because it indicates the different levels of knowledge within a community), for studies intended to discover new drugs (because it indicates the peculiarities of certain groups), and for biodiversity conservation strategies.

Introduction The Argentina Continental Margin (MCA) is one of the largest margins around the world (2x10(6) km²), which in most of its area of development (between 35 and 48ºS) belongs to a typical extensional volcanic passive margin (Mohriak et al., 2002). The region is located in a key area of the Southwestern Atlantic Ocean due to its significance in the global oceanographic-climatic interaction (Wefer et al., 1996, 2004; Carter and Cortese, 2009). As a result, the study of the Cenozoic sedimentary sequences preserved in the geological record is very important for paleoceanographic-paleoclimatic-paleoenvironmental reconstructions. The study area is included in the northern part of the MCA adjacent to eastern Buenos Aires province (Fig. 1a). The major physiographic units are the shelf, slope, rise and the Mar del Plata Submarine Canyon. This work describes the Cenozoic morphosedimentary, stratigraphic and evolutive aspects of the continental slope in the region. The study is based on high resolution seismic (multi and monochannel) complemented with sediment analysis on piston and gravity cores as well as grab sa

El Margen Continental Argentino es uno de los márgenes más extensos del mundo (2 x 10(6) km²) cuyo mayor desarrollo, entre 35 y 48ºS, corresponde a un típico margen pasivo volcánico. Allí se desarrollan los siguientes rasgos: plataforma, talud, emersión y el Cañón Submarino Mar del Plata. Este trabajo describe los aspectos morfosedimentarios, estratigráficos y evolutivos del talud adyacente al litoral del este bonaerense. El estudio se basó en información sísmica mono y multicanal de alta resolución complementada con el análisis de muestras del fondo marino, fundamentalmente testigos verticales. El talud se desarrolla entre 120 y 3500 m de profundidad. Está formado por tres sectores principales. El más cercano a la plataforma es el talud superior situado por encima de los 700/800 m, de fuerte pendiente. A partir de allí se desarrolla el talud medio, constituido por la Terraza Ewing, cuya superficie de baja pendiente llega hasta los 1300 m de profundidad. Finalmente, el talud inferior vuelve a ser de fuerte pendiente y llega hasta los 3500 m, desde donde grada hacia la emersión continental. El talud es atravesado por el Cañón Submarino Mar del Plata, que comienza alrededor de los 500 m de profundidad aunque adquiere una típica configuración de valle en V entre 1200 y 3700 metros. La cobertura sedimentaria del talud es silicoclástica, formada por fangos algo arenosos que muestran mayores porcentajes de arena e inclusive rodados en los alrededores del cañón, particularmente en sus cabeceras. La asociación mineralógica es volcánico-piroclástica de origen pampeano-patagónico. A través de la aplicación de métodos sismoestratigráficos se identificaron siete "Secuencias Depositacionales" que abarcan desde el Cretácico superior hasta el presente, las cuales están separadas por horizontes sísmicos mayores que representan discontinuidades resultantes de la ocurrencia de significativos eventos climáticos-oceanográficos de amplia extensión regional. La sucesión de secuencias señala que el talud comenzó a evolucionar a partir de la transición Eoceno-Oligoceno en respuesta a complejos procesos de agradación y progradación con depósitos turbidíticos y contorníticos, y formación de cañones submarinos. Se definen cuatro etapas evolutivas principales: 1) Agradacional, del Cretácico-Eoceno, con fuerte acreción vertical del talud asociada a subsidencia térmica de la Cuenca del Salado, con alta tasa de sedimentación. 2) Desarrollo del talud durante el Eoceno superior-Mioceno medio, cuando se estructura el margen pasivo y comienza a evidenciarse la influencia de las masas de agua de origen antártico, lo que se manifiesta en la formación de secuencias sedimentarias complejas con períodos alternantes de progradación-retrogradación aunque con predominio de los primeros (con alta dinámica turbidítica y formación de cañones submarinos) que hacen avanzar progresivamente el talud en dirección al mar. 3) Desarrollo de la Terraza Ewing en el Mioceno medio-superior, cuando la dinámica sedimentaria asociada a la circulación de las corrientes oceánicas de origen antártico favorece la migración hacia el norte de grandes depósitos contorníticos. 4) Configuración definitiva del talud en el Plioceno-Cuaternario, al desarrollarse la Terraza Ewing y el Cañón Submarino Mar del Plata con sus características presentes.