Abstract Saccharomyces cerevisiae (S. cerevisiae) has been studied as a model microorganism to understand the mechanism of glutathione (GSH) production. Furthermore, magnetic field (MF) application is a novel approach to stimulate microorganism metabolism to increase growth and produce more biomolecules. This study aimed to evaluate whether GSH production by S. cerevisiae ATCC 7754 would be affected by different pressure levels and MF application in an airlift bioreactor. Influence of pressure (0.0 - 0.15 MPa), medium recycle velocity (3.0 and 15.0 cm s-1) and MF application (0.0 and 3.0 mT) was evaluated. Biomass and GSH concentrations at high pressure and medium recycle velocity were higher than the ones in the control, whereas MF decreased biomass and GSH concentrations. The best results of biomass concentration and GSH production were 17.79 g L-1 and 162.92 mg L-1, respectively. at 0.05 MPa, 15.0 cm s- 1 and without any MF application. Results of the pressured airlift bioreactor showed that this kind of reactor may be used for producing GSH and for reducing energy costs.

O artigo analisa o modelo de Gestão Compartilhada de P&D entre a Petrobras e a Universidade Federal do Rio Grande do Norte (UFRN) à luz das teorias da Dependência de Recursos e de Redes Interorganizacionais. Este sistema é uma parceria tecnológica alinhada ao modelo da hélice tripla, onde o conhecimento está sendo construído através da interação empresa & universidade & governo. A parceria, incentivada pela Lei do Petróleo, é coordenada pelo Centro de Pesquisas da Petrobras e serviu de modelo para a criação de redes temáticas da Petrobras. As redes desenvolvem as pesquisas que, por alguma razão, não podem ser realizadas pela estrutura própria da companhia e atuam de forma complementar a seus processos internos de P&D. Apresenta-se o histórico do relacionamento entre a organização empresarial de base tecnológica e a organização acadêmica. Fazem-se considerações teóricas sobre o modelo ao mesmo tempo que são propostos alguns pontos para melhoria.

The article analyzes the model of Shared Management of R & D between Petrobras and the Federal University of Rio Grande do Norte according to the theories of Resource Dependence and Interorganizational Networks. This system is a technological partnership aligned to the triple helix model, where knowledge is being built through the interaction of firm & university & government. The partnership encouraged by the Petroleum Law, is coordinated by the Research Center of Petrobras and served as a model for the creation of thematic networks of Petrobras. Those networks develop the researches that for some reason cannot be performed by the company's own structure and acts in a complementary way to its internal processes of R & D. The article also presents the history of the relationship between a business-technology based firm with an academic organization. Also are presented some theoretical considerations on the model meanwhile are suggested some points for improvement.