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Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

SOLUÇÕES PARA PROBLEMAS PÚBLICOS EM JUÍZO: UMA PRÁTICA INTERDISCIPLINAR ENTRE CAMPO DE PÚBLICAS E DIREITO
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Silveira, Raquel Maria da Costa

; Leite, Gisele Maria da Silva Araújo

; Cavalcanti, Flávio Luiz Carneiro

; Meira, Maísa de Oliveira

; Inácio, Márcio Vinícius do Nascimento

Cadernos Gestão Pública e Cidadania

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2023, Volume 28 elocation e86370

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT This article reflects on the experience of the university extension project Building Collaborative Solutions for Judicialized Public Issues, highlighting the potential of the Public Field in the debate about judicialized public issues. The study was based on bibliographic and documentary research and interviews with students who participated in the extension project. The results showed the lessons learned from participating in the project and from the Undergraduate Program in Public Policy Management of the Universidade Federal do Rio Grande do Norte, which is related to the extension project. Also, the findings show the benefits of extension projects to motivate participants to engage in innovative learning opportunities. The study demonstrates the potential of the project to contribute to mediating judicialized public conflicts and, equally, to strengthening the link between knowledge and teaching, research, and extension. The project has achieved concrete results, expanding the dialogue between the many institutions involved.

RESUMEN Este artículo pretende reflexionar sobre la experiencia del Proyecto de Extensión “Construyendo Soluciones Colaborativas para Conflictos Públicos Judicializados”, tomándolo como base para resaltar el potencial del Campo de las Políticas Públicas en el debate sobre los conflictos públicos que se judicializan. Para ello, se ha basado en la investigación bibliográfica y documental. Además, se recogió información sobre la percepción de los estudiantes participantes a través de entrevistas, generando resultados relacionados con los aprendizajes construidos y proporcionados por la participación en esta extensión, así como los de la Licenciatura en Gestión de Políticas Públicas de la Universidade Federal do Rio Grande do Norte y la contribución del proyecto, como actividad extensionista, en la motivación de la búsqueda de nuevos aprendizajes. Al final, se destacó el potencial de la iniciativa en la participación de las mediaciones para los conflictos públicos judicializados e, igualmente, en el fortalecimiento del vínculo entre los conocimientos y entre la enseñanza, la investigación y la extensión. Se demostró que el proyecto ha ido generando resultados concretos, ampliando la apertura al diálogo entre diversas instituciones.

RESUMO O presente artigo objetiva refletir sobre a experiência do Projeto de Extensão Construindo Soluções Colaborativas para Questões Públicas Judicializadas, tomando-a como base para destacar a potencialidade do Campo de Públicas no debate sobre conflitos públicos judicializados. Para tanto, fundamentou-se em pesquisas bibliográfica e documental. Além disso, foram coletadas informações sobre a percepção dos discentes participantes por meio de entrevistas, gerando resultados relativos aos aprendizados construídos e proporcionados pela participação nessa extensão, como também por aqueles próprios do Bacharelado em Gestão de Políticas Públicas da Universidade Federal do Rio Grande do Norte e do Projeto, como atividade extensionista, na motivação para a busca de novas aprendizagens. Ao final, foram destacadas as potencialidades da iniciativa na participação de mediações para conflitos públicos judicializados e, igualmente, no fortalecimento do elo entre saberes e o ensino, a pesquisa e a extensão. Demonstrou-se que o Projeto vem gerando frutos concretos, ampliando a abertura ao diálogo entre diversas instituições.

https://doi.org/10.12660/cgpc.v28.86370

A systematic review of hormone levels, biomarkers of cellular injury and oxidative stress in multi-stressor military field training exercises
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Silva, Filipe Brasil e

; Vaisman, Mario

; Ponce, Thalita

; Barros, Thiago Ramos de

; Silva, Camila Brasil e

; Salerno, Verônica Pinto

; Mainenti, Míriam Raquel Meira

Archives of Endocrinology and Metabolism

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jun 2022, Volume 66 N. 3 Pages 382 - 392

Abstract: En | Text: En | PDF: En

ABSTRACT The fundamental objective of military field training exercises (FTX) is to prepare military personnel for real-life operations through simulated scenarios. These training sessions often require extreme physical efforts with prolonged, high-intensity exercises that can be combined with food restrictions and partial, or total, sleep deprivation. Such conditions can compromise an individual’s physical performance and cause tissue damage, thus affecting their health. This study aimed to perform a systematic review of the literature to identify studies that measured the changes in hormone levels and biomarkers of cellular injury and oxidative stress resulting from FTX with high levels of energy expenditure combined with food and sleep restrictions. PubMed and the Scopus database were searched for articles that combined physical effort/food restriction/sleep deprivation with military training. The initial database search identified 158 articles that were reduced to 18 after confirmation. Significant reductions were reported in thyroid hormones, T3, T4, and anabolic hormones such as testosterone, insulin and androstenedione. An exception for GH was found, which increased throughout FTX. Less distinct responses to FTX were observed with cortisol, TSH and LH. The presence of biomarkers for cellular damage (myoglobin, TNF, and CRP) and increased immune response activities were also described. The scarcity of information on oxidative stress, analyses of cellular injury and biomarkers of inflammatory responses warrants the future study of these topics, which could be helpful in facilitating the safe and effective physical preparations of the members of the armed forces.

https://doi.org/10.20945/2359-3997000000443

Running velocity at maximum oxygen uptake and at maximum effort: important variables for female military pentathlon
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Mainenti, Míriam Raquel Meira

; Vigário, Patrícia dos Santos

; Batista, Hugo Brito

; Bastos, Luiz Fernando Valverde

; Mello, Danielli Braga de

Motriz: Revista de Educação Física

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2022, Volume 28 N. spe1 elocation e10220018921

Abstract: En | Text: En | PDF: En

Abstract Aim: to correlate cardiopulmonary capacity widely used variables with athletic performance in 4 km cross country race, in elite female military pentathlon athletes. Methods: Five military pentathlon athletes from Brazilian team with 27.5 [25.0; 29.3] years old underwent an incremental ramp treadmill test to determine VO2max, vVO2max (velocity of initial VO2 plateau), maximum velocity, and these same variables in anaerobic threshold. Furthermore, the performance obtained on the cross-country race of the last trial before the world military games was recorded. Spearman’s correlations were used to investigate the association between cardiopulmonary variables and athletic performance (p < 0.05). Results: The athletes exhibited a median total body weight of 64.3 [60.9; 66.6] kg and height of 1.75 [1.66; 1.76] cm. Race performance was positively correlated with vVO2max (r = 0.98, very strong correlation) and maximum velocity reached (r = 0.95, very strong correlation). The remaining cardiopulmonary variables did not show similar behavior, with r varying between -0.26 and 0.44. Conclusion: Maximum velocity and vVO2max indicators are directly related to athletic performance in the 4 km cross country race of elite female military pentathlon athletes. Thus, the technical team must pay particular attention to athletic performance in these cardiopulmonary variables in both the selection of new athletes and the identification of the effectiveness of applied training strategies.

https://doi.org/10.1590/s1980-657420220018921

Female military pentathlon athletes and scientific research - a mini-review
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Mainenti, Míriam Raquel Meira

; Miarka, Bianca

; Loyola, Marcos Vinícius Marques

; Santos, Lucas Vieira Coelho dos

; Mello, Danielli Braga de

Motriz: Revista de Educação Física

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2022, Volume 28 N. spe1 elocation e10220017921

Abstract: En | Text: En | PDF: En

Abstract Aim: to compile existing information in the scientific literature on female military pentathlon athletes. Methods: searches were performed on Pubmed/Medline, Scielo, and Scholar Google databases with specific strings in English and Portuguese. Results: military pentathlon is a discipline that comprises five events, namely: rifle shooting, obstacle run, obstacle swimming, throwing, and cross country running. Our search initially identified 275 records, which were reduced to the final list of 14 after the eligibility criteria analysis was performed in two phases: title + abstract reading and full-text reading. The first record was published in 2007 (recent field of study) and most studies were cross-sectional ones (scarcity of experimental studies), investigating outcomes like psychological, anthropometric, biochemical, biomechanics, cardiopulmonary, nutritional, skin temperature, performance, and prevalence of injury. The female military pentathlon athletes present low values of body fat, energy intake, and high weekly training volume, so professionals must be aware to prevent relative energy deficiency in sports (RED-S) syndrome. The obstacle run was the most investigated event, with lower blood lactate and skin temperature for women athletes. It was also observed that anthropometric, muscle power, and cardiopulmonary variables are well correlated with athletic performance and in some studies, these correlations were stronger for female athletes. Conclusion: scientific research with female military pentathlon athletes is still incipient, especially for experimental design researches, which are highly encouraged in future studies.

https://doi.org/10.1590/s1980-657420220017921

Association between the orientation received during hospitalization and the occurrence of wound healing
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Ramos, Fabiana Tomé

; Meira, Jéssica Renata Reis de

; Colenci, Raquel

; Alencar, Rúbia de Aguiar

Revista Brasileira de Enfermagem

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2021, Volume 74 N. 2 elocation e20190647

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: avaliar se há associação entre a orientação recebida durante a internação e a ocorrência de cicatrização de feridas na perspectiva do paciente após a alta hospitalar. Métodos: coorte concorrente, com follow-up de 180 dias, realizada em Enfermaria de Dermatologia. Foram avaliados 62 pacientes com feridas que necessitaram de cuidado após alta, entre julho de 2015 e novembro de 2016. Informações sobre a orientação foram obtidas por ligação telefônica entre 7 e 10, 60, 120 e 180 dias após alta. Resultados: quanto maior a idade, menor a chance de cicatrização em até 10 dias; e quanto maior o tempo de internação, menor a chance de cicatrização. Receberam orientação na alta 90,3%, enquanto 87% entenderam as orientações. Conclusões: não houve associação entre a orientação recebida durante a internação e a ocorrência de cicatrização de feridas na perspectiva do paciente após a alta hospitalar.

ABSTRACT Objectives: to assess whether there is an association between the orientation received during hospitalization and the occurrence of wound healing from the patient’s perspective after hospital discharge. Methods: concurrent cohort, with 180-day follow-up, held in Dermatology Ward. A total of 62 patients with wounds requiring care after discharge were evaluated between July 2015 and November 2016. Information about the orientation was obtained by phone call between 7 and 10, 60, 120 and 180 days after discharge. Results: the older the patient, the lower the chance of healing in up to ten days; and the longer the hospitalization, the lower the chance of healing. They received orientation in the high 90.3%, while 87% understood the orientations. Conclusions: there was no association between the orientation received during hospitalization and the occurrence of wound healing from the patient’s perspective after hospital discharge.

RESUMEN Objetivos: evaluar si hay relación entre la orientación recibida durante la internación y la ocurrencia de cicatrización de heridas en la perspectiva del paciente después del alta hospitalaria. Métodos: corte concurrente, con follow-up de 180 días, realizada en Enfermería de Dermatología. Se evaluaron 62 pacientes con heridas que necesitaran de cuidado después del alta, entre julio de 2015 y noviembre de 2016. Informaciones sobre la orientación han sido obtenidas por llamada telefónica entre 7 y 10, 60, 120 y 180 días después del alta. Resultados: cuanto mayor la edad, menor la chance de cicatrización en hasta 10 días; y cuanto mayor el tiempo de internación, menor la chance de cicatrización. Recibieran orientación en la alta 90,3%, mientras 87% comprendieran las orientaciones. Conclusiones: no hubo relación entre la orientación recibida durante la internación y la ocurrencia de cicatrización de heridas en la perspectiva del paciente después del alta hospitalaria.

https://doi.org/10.1590/0034-7167-2019-0647 122 downloads

Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits
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Meira, Raquel de Oliveira

; Braga, Daniel Nogueira Mendes

; Pinheiro, Leni Safira Gonçalves

; Amorim, Izabela Ferreira Gontijo

; Vasconcellos, Leonardo de Souza

; Alberti, Luiz Ronaldo

Acta Cirúrgica Brasileira

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2020, Volume 35 N. 10 elocation e202001006

Abstract: En | Text: En | PDF: En

Abstract Purpose: To evaluate and compare the effects of homologous and heterologous PRP (Platelet-Rich Plasma) on the quality and speed of skin wound healing, compared to Poor Platelet Plasma (PPP). Methods: Twenty-one male adult rabbits were used; two for preparing homologous PRP, with the rest of them separated randomly in three groups, according to the treatment received: PPP - control (n=5), homologous PRP (n=7), heterologous (n=7). Excisional skin wounds were made on the back of the animals, for the application of homologous and heterologous PPP and PRP. At the 14th post-operative day (POD), the animals were subjected to a new wound, and the treatments were inverted. The wounds were evaluated macroscopically and histologically. Results: A larger percentage of scar retraction was observed on the group treated with heterologous PRP, compared to homologous PRP, at the third POD, an increase of 25.03% (p=0.01). No other statistically significant differences among treatments were observed. Among every group, skin healing was efficient, without local adverse effects. Conclusions: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets, which could also contribute to the wound healing process, and thus, should be further investigated.

https://doi.org/10.1590/s0102-865020200100000006 564 downloads

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial
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Werneck, Francisco Zacaron

; Coelho, Emerson Filipino

; Almas, Saulo Peters

; Garcia, Marília Mendes do Nascimento

; Bonfante, Heloina Lamha Machado

; Lima, Jorge Roberto Perrout de

; Vigário, Patrícia dos Santos

; Mainenti, Míriam Raquel Meira

; Teixeira, Patrícia de Fátima dos Santos

; Vaisman, Mário

Archives of Endocrinology and Metabolism

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oct 2018, Volume 62 N. 5 Pages 530 - 536

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. Subjects and methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) - participants that performed an exercise program - and sHT-Sed (n = 10) - controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months. Results: Women with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (770 ± 23.0 vs. 88.8 ± 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes. Conclusion: After 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT.

https://doi.org/10.20945/2359-3997000000073 4516 downloads

POSTURAL CONTROL IN ATHLETES WITH DIFFERENT DEGREES OF VISUAL IMPAIRMENT
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Santos, Claudemir do Nascimento

; Carvalho, Thiago Lemos de

; Felício, Lilian Ramiro

; Mainenti, Míriam Raquel Meira

; Vigário, Patrícia dos Santos

Journal of Physical Education

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2018, Volume 29 elocation e2936

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo do estudo foi descrever o controle postural na posição ereta semiestática de atletas com diferentes graus de deficiência visual e verificar se existem diferenças de acordo com a modalidade esportiva praticada. Participaram deste estudo seccional 22 atletas com perda total da visão (classificação funcional B1) e 17 com baixa visão (classificação funcional B2 e B3) das modalidades judô (n=17), goalball (n=12) e futebol de cinco (n=10). O controle postural foi investigado utilizando uma plataforma de força, sendo calculadas a área da elipse de 95% de intervalo de confiança (mm2) e a velocidade média de deslocamento (mm/s). A tarefa postural foi realizada com os pés unidos e olhos fechados e vendados. Atletas com perda total da visão apresentaram menores valores para área de oscilação (p=0,02) em relação aos atletas com baixa visão. Na comparação quanto à modalidade esportiva, foi possível observar que os atletas de goalball oscilaram menos e apresentaram menor velocidade de deslocamento que os atletas de judô. Em paralelo, os jogadores de futebol de cinco foram aqueles que apresentaram melhor controle postural. As diferenças encontradas no controle postural de atletas com deficiência visual parecem estar associadas ao grau de perda visual e às especificidades das modalidades esportivas.

ABSTRACT The aim of this study was to describe postural control in athletes with different degrees of visual impairment in erect semi-static position and verify whether it differs with sport modalities. Twenty-two athletes with total loss of vision (functional classification B1) and 17 with partial loss of vision (functional classification B2 and B3) were included in this cross-sectional study. Their sport modalities were judo (n = 17), goalball (n = 12) and five-a-side football (n=10). Postural control was investigated on a force platform with athletes in bipedal stance with eyes closed and blindfolded. The elliptical area of 95% confidence interval (mm2) and the mean displacement velocity (mm/s) were calculated. Athletes with total loss of vision presented smaller oscillation area values (p = 0.02) when compared to athletes with partial loss of vision. Considering sport modality, five-a-side athletes were found to present the best postural control. Moreover, goalball athletes oscillated less and presented a lower mean displacement velocity in relation to judoists. The differences found in postural control in visually impaired athletes seem to be associated with the degree of loss of vision and specificities of each sport modality.

https://doi.org/10.4025/jphyseduc.v29i1.2936 1265 downloads

10.

ATLETAS DE PENTATLO MILITAR FEMININO COM MELHOR COMPOSIÇÃO CORPORAL APRESENTAM MELHOR DESEMPENHO NA MODALIDADE
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Schramm, Fernando Fracalossi

; Bastos, Luiz Fernando Valverde

; Mainenti, Míriam Raquel Meira

Journal of Physical Education

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2017, Volume 28 elocation e2806

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Com a recente ampliação do público feminino nas forças armadas, cresce a necessidade de estudos sobre a seleção e o treinamento das atletas militares brasileiras. O objetivo do estudo foi determinar as características antropométricas das atletas de Pentatlo Militar da equipe do Exército, e identificar quais variáveis estão presentes nas atletas de melhor desempenho na modalidade. Foram coletados os dados antropométricos e de desempenho atlético (seletiva para os 6º Jogos Mundiais Militares 2015) de cinco atletas de Pentatlo Militar do Exército e foram realizadas análises de grupamentos (Cluster). Foi observada a existência de dois grupos quanto à composição corporal: o formado pelas atletas com os maiores valores de massa livre de gordura e circunferência muscular do braço, bem como menores valores de soma de dobras cutâneas e percentual de gordura, pertenciam ao grupo de melhores atletas quanto a rendimento nas provas. Esse comportamento não foi observado para dimensões corporais.

ABSTRACT The recent increase of the women working for the military forces augments the need for studies that aim to optimize the selection and training of Brazilian athletes. The aim of the present study was to determine the anthropometric characteristics of female Military Pentathlon Army team, and identify which variables present the best values within the best performance athletes group. We collected anthropometric and performance data (selective for the 6th Military World Games) from five athletes of female Military Pentathlon Army team and data were analized by cluster analysis. It has been detected two groups in terms of body composition: one composed by the athletes with the highest fat free mass values and arm muscle circumference, as well as smaller sum of skinfold values and fat percentage which also composed the group of top athletic performance athletes. This fact was not observed for body size variables.

https://doi.org/10.4025/jphyseduc.v28i1.2806 1631 downloads

11.

THE IMPACT OF PILATES EXERCISES ON THE POSTURAL ALIGNMENT OF HEALTHY ADULTS
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Krawczky, Bruna

; Mainenti, Míriam Raquel Meira

; Pacheco, Antonio Guilherme Fonseca

Revista Brasileira de Medicina do Esporte

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dec 2016, Volume 22 N. 6 Pages 485 - 490

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: Os exercícios do método Pilates têm sido amplamente utilizados com a finalidade de melhorar o alinhamento postural. Existem evidências científicas fortes que favorecem seu uso na melhora da flexibilidade e do equilíbrio, bem como alguma evidência de melhora da força muscular. Entretanto, os benefícios relacionados à postura não estão bem estabelecidos. Objetivo: Investigar, em adultos saudáveis, o impacto do método Pilates no alinhamento postural, por meio de alguns ângulos no plano sagital e da ocorrência de dor antes e após uma sessão de exercícios, e também após o término de um programa de 16 sessões. Métodos: Este é um estudo quase-experimental do tipo pré e pós-intervenção. Adultos saudáveis (n = 37) interessados em iniciar Pilates foram avaliados quanto aos efeitos agudos sobre a postura após uma sessão de Pilates (n = 37) e após um programa de 16 sessões, por um período de 10 semanas (n = 13). Usando o software para análise postural (SAPO), seis ângulos foram analisados: alinhamento horizontal da cabeça (AHC); alinhamento horizontal da pelve (AHP), ângulo do quadril (AQ), alinhamento vertical do corpo (AVC), cifose torácica (CT) e lordose lombar (LL). A ocorrência de dor foi investigada para controlar efeitos adversos. Resultados: Diferenças estatisticamente significativas (p < 0,05) encontradas após uma sessão incluem aumento do AHC (perfil esquerdo), redução do AVC (perfil esquerdo) e da CT (ambos os perfis). Depois de 16 sessões, foi observado aumento do AHC e redução da CT, LL (ambos os perfis) e AQ (perfil direito). Todas as diferenças encontradas apontam para a melhora do alinhamento postural. Uma redução significativa de prevalência de dor foi verificada após a primeira sessão (40,5% vs. 13,5%; p = 0,004) e após o programa completo (30,8% vs. 15,3%; p = 0,02). Conclusões: Nossos resultados sugerem que o método Pilates tem impacto positivo sobre o alinhamento postural de adultos saudáveis, além de ser um exercício físico seguro.

ABSTRACT Introduction: Exercises of Pilates method have been widely used to improve postural alignment. There is strong evidence favoring their use in improving flexibility and balance, as well as some evidence of improvement in muscle strength. However, the benefits related to posture are not well established. Objective: To investigate in healthy adults, the impact of the Pilates method in the postural alignment through some angles in the sagittal plane and the occurrence of pain before and after an exercise session, and after the completion of a 16-session program. Methods: This is a quasi-experimental study of pre and post-intervention type. Healthy adults (n = 37) interested in starting Pilates were evaluated for acute effects on posture after a Pilates session (n = 37) and after a 16-session program, for a period of 10 weeks (n = 13). Using the postural assessment software (SAPO), six angles were analyzed: head horizontal alignment (HHA), pelvis horizontal alignment (PHA), hip angle (HA), vertical alignment of the body (VAB), thoracic kyphosis (TK), and lumbar lordosis (LL). The occurrence of pain was investigated to control adverse effects. Results: Statistically significant (p<0.05) differences found after one session include increased HHA (left view), decreased VAB (left view) and TK (both side views). After 16 sessions, we observed an increase of HHA, and a decrease of TK, LL (both side views) and HA (right view). All the differences point to an improvement of postural alignment. A significant reduction of prevalence of pain was verified after the first session (40.5% vs. 13.5%; p=0.004) and after the full program (30.8% vs. 15.3%; p=0.02). Conclusions: Our results suggest that the Pilates method has a positive impact on postural alignment in healthy adults, besides being a safe exercise.

RESUMEN Introducción: Los ejercicios del método Pilates se han utilizado ampliamente con el fin de mejorar la alineación postural. Hay una fuerte evidencia científica que favorece su uso para la mejora de la flexibilidad y el equilibrio, así como algunos indicios de mejora de la fuerza muscular. Sin embargo, los beneficios relacionados con la postura no están tan bien establecidos. Objetivo: Investigar en adultos sanos, el impacto del método de Pilates en la alineación postural a través de algunos ángulos en el plan sagital y en la aparición de dolor antes y después de una sesión de ejercicios, y también después de un programa de 16 sesiones. Métodos: Se trata de un estudio cuasi-experimental del tipo antes y después de la intervención. Se evaluaron adultos sanos (n = 37) interesados en iniciar Pilates para efectos agudos sobre la postura después de una sesión de Pilates (n = 37) y después de un programa de 16 sesiones durante 10 semanas (n = 13). Usando el software para el análisis postural (SAPO), se analizaron seis ángulos: alineación horizontal de la cabeza (AHC); alineación horizontal de la pelvis (AHP), el ángulo de cadera (AC), la alineación vertical del cuerpo (AVC), cifosis torácica (CT) y la lordosis lumbar (LL). La aparición de dolor se investigó para controlar los efectos adversos. Resultados: Las diferencias estadísticamente significativas (p < 0,05) encontradas después de una sesión incluyen aumento de AHC (perfil izquierdo), reducción de la AVC (perfil izquierdo) y aumento de la CT (ambos perfiles). Después de 16 sesiones, se observó un aumento de la AHC y reducción de la CT, LL (ambos perfiles) y AC (perfil derecho). Todas las diferencias apuntan a la mejora de la alineación postural. Se observó una reducción significativa en la prevalencia del dolor después de la primera sesión (40,5% vs. 13,5% p = 0,004) y después del programa completo (30,8% vs. 15,3%, p = 0,02). Conclusiones: Nuestros resultados sugieren que el método Pilates tiene un impacto positivo sobre la alineación postural en adultos sanos, además de ser un ejercicio seguro.

https://doi.org/10.1590/1517-869220162206153957 8687 downloads

12.

Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndromes: a Brazilian cohort screening study
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Donaires, Flávia Sacilotto

; Martelli, Felipe

; Alves-Paiva, Raquel de Melo

; Magalhães, Silvia Maria Meira

; Pinheiro, Ronald Feitosa

; Calado, Rodrigo Tocantins

Revista Brasileira de Hematologia e Hemoterapia

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dec 2016, Volume 38 N. 4 Pages 320 - 324

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Myelodysplastic syndromes (MDS) comprise a group of malignant clonal hematologic disorders characterized by ineffective hematopoiesis and propensity for progression to acute myeloid leukemia. Acquired mutations in the gene encoding RNA splicing factor 3B subunit 1 (SF3B1) are highly associated with the MDS subtypes presenting ring sideroblasts, and represent a specific nosological entity. The effects of these mutations on clinical outcomes are diverse and contrasting. Methods: A cohort of 91 Brazilian MDS patients, including patients with ring sideroblasts in the bone marrow, were screened for mutations in the SF3B1 hotspots (exons 12-15) by direct Sanger sequencing. Results: SF3B1 heterozygous mutations were identified in six patients (7%), all of them with ring sideroblasts, thus confirming the association between SF3B1 mutations and myelodysplastic syndrome subtypes bearing this morphologic feature (frequency of 6/13, p-value < 0.0001). Conclusion: This is the first screening of SF3B1 mutations in a cohort of Brazilian myelodysplastic syndrome patients. Our findings confirm that mutations in this splicing gene correlate with bone marrow ringed sideroblasts.

https://doi.org/10.1016/j.bjhh.2016.06.002 955 downloads

13.

Does low serum TSH within the normal range have negative impact on physical exercise capacity and quality of life of healthy elderly people?
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Chachamovitz, Dhiãnah Santini de Oliveira

; Vigário, Patrícia dos Santos

; Carvalho, Rafael Cavalcante

; Silvestre, Diego Henrique da Silva

; Moerbeck, Ana Eduarda Vieira

; Soffientini, Mariana Guimarães

; Luna, Érika Luciana Gomes

; Rosemberg, Clara Werner

; Mainenti, Míriam Raquel Meira

; Vaisman, Mário

; Teixeira, Patricia de Fátima dos Santos

Archives of Endocrinology and Metabolism

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jun 2016, Volume 60 N. 3 Pages 236 - 245

Abstract: En | Text: En | PDF: En

Objective Investigate the differences in cardiopulmonary (CP) capacity and Quality of Life (QOL) between healthy elderly (≥ 65 years) with different TSH levels (< 1.0 and ≥ 1.0 μIU/mL) both within the normal range. Also, evaluate the effects of TSH elevation on CP test and QOL, by administering methimazole to subjects with initial lower-normal TSH, in order to elevate it to superior-normal limit. Materials and methods Initially, a cross-sectional study was performed to compare CP capacity at peak exercise and QOL (using WHOQOL-OLD questionnaire) between healthy seniors (age ≥ 65 years) with TSH < 1.0 μIU/mL vs. TSH ≥1.0 μIU/mL. In the second phase, participants with TSH < 1.0 μIU/mL were included in a non-controlled-prospective-interventional study to investigate the effect of TSH elevation, using methimazole, on QOL and CP capacity at peak exercise. Results From 89 elderly evaluated, 75 had TSH ≥ 1 μIU/mL and 14 TSH < 1 μIU/mL. The two groups had similar basal clinical characteristics. No difference in WHOQOL-OLD scores was observed between groups and they did not differ in terms of CP function at peak exercise. QOL and CP variables were not correlated with TSH levels. Twelve of 14 participants with TSH < 1.0 μIU/mL entered in the prospective study. After one year, no significant differences in clinical caracteristics, QOL, and CP variables were detected in paired analysis before and after methimazole intervention. Conclusions We found no differences in CP capacity and QOL between health elderly with different TSH levels within normal range and no impact after one year of methimazole treatment. More prospective-controlled-randomized studies are necessary to confirm or not the possible harm effect in normal low TSH.

https://doi.org/10.1590/2359-3997000000079 4716 downloads

14.

Association among body composition, muscle performance and functional autonomy in older adults
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Gonçalves, Bruno Lucas

; Guimarães, Fernando Silva

; Souza, Marcel Lima Lessa de

; Ferreira, Arthur de Sá

; Mainenti, Míriam Raquel Meira

Fisioterapia em Movimento

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mar 2015, Volume 28 N. 1 Pages 49 - 59

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Introdução A diminuição da massa muscular e o aumento da gordura corporal são alterações marcantes do envelhecimento. O declínio de força e de resistência à fadiga pode levar o idoso à diminuição da autonomia funcional. Objetivo O presente estudo teve como objetivo verificar a existência de relação entre composição corporal, força muscular, fadiga de membros inferiores e autonomia funcional em idosas ativas. Materiais e métodos A amostra foi constituída de 29 idosas com idade média de 68,2 (± 7,3) anos. Foram analisadas a composição corporal pela bioimpedância total e segmentar e a fadiga muscular por meio da eletromiografia, pelos valores de frequência mediana e da raiz quadrática média, em um teste de um minuto a 50% da contração voluntária máxima. A autonomia funcional foi avaliada pelo protocolo do Grupo de Desenvolvimento Latino-Americano para a Maturidade (GDLAM). Resultados Foram observadas correlações significativas entre estatura e força (r = 0,49), idade e massa magra (r = -0,42), percentual de gordura (%G) e testes do GDLAM (r de 0,39 a 0,41). A massa magra se correlacionou positivamente com a força (r = 0,55), mas não com o resultado do teste de resistência à fadiga. Conclusão A massa magra das idosas avaliadas está associada ao desempenho no teste de força máxima, mas não no de resistência à fadiga, mostrando que esses dois parâmetros (força e fadiga) se comportam de maneira independente. As idosas com maior %G tiveram um pior desempenho no GDLAM, mostrando que indivíduos idosos com maiores níveis de adiposidade corporal apresentam mais limitações relacionadas à autonomia funcional.

Introduction Decrease in muscle mass and increase in body fat are important changes that occur with aging. Strength decline and worse resistance to fatigue can lead to a decreased functional autonomy of the elderly. Objective The present study aimed to verify the existence of a relationship between body composition, muscle strength, lower limbs fatigue and functional autonomy in active elderly women. Materials and methods The sample consisted of 29 elderly women with a mean age of 68.2 (± 7.3) years. Body composition was analyzed by total and segmental bioelectrical impedance. Muscle fatigue was assessed using electromyography, through the analysis of median frequency and root mean square during a 60-second sustained isometric knee extension contraction, at 50% of the maximum voluntary isometric contraction. Functional autonomy was assessed by using the Latin American Development Group for Maturity (GDLAM) protocol. Results There were significant correlations between height and strength (r = 0.49), age and lean body mass (r = -0.42), body fat percentage (BF%) and GDLAM tests (r = 0.39-0.41). The lean body mass was positively correlated with strength (r = 0.55), but not with resistance to fatigue. Conclusion The lean body mass of the analyzed sample was found to be associated with the performance on the maximum strength test, but not with the performance on the resistance to fatigue test. This shows that these two parameters (strength and fatigue) are independent of one another. Elderly women with higher BF% showed worse performance on the GDLAM tests. This evidences that individuals with high adiposity levels tend to have a more limited functional autonomy.

https://doi.org/10.1590/0103-5150.028.001.AO05 2802 downloads

15.

Pulpotomy in deciduous tooth with mineral trioxid aggregate
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PIVA, Fabiane

; COELHO-DE-SOUZA, Fábio Herrmann

; MEIRA, Raquel

; ROTTA, Gabriela Taube

; VOLKWEISS, Taytianne

RGO - Revista Gaúcha de Odontologia

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dec 2014, Volume 62 N. 4 Pages 449 - 452

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Diversos medicamentos vêm sendo testados e utilizados na terapia pulpar conservadora de dentes decíduos, no entanto, o formocresol continua sendo o material de escolha nas pulpotomias, mesmo não atendendo às exigências de biocompatibilidade e promovendo a fixação do tecido pulpar vital e não o seu reparo. Com o surgimento do Agregado Trióxido Mineral (MTA) como um material com propriedades físico-químicas que promovem o reparo tecidual, aliados a outras propriedades importantes, tais como a ação antimicrobiana e a biocompatibilidade aos tecidos pulpares surgiu uma nova alternativa de material na Odontologia. O objetivo deste estudo foi relatar o desempenho do MTA em uma pulpotomia em molar decíduo e seu acompanhamento por um período de 1 ano. Foi realizada a pulpotomia com o uso do MTA no dente 85 de um paciente de 5 anos de idade cujos resultados obtidos foram bastante favoráveis, demonstrando sucesso clínico e radiográfico no período avaliado. Apesar do pouco tempo de acompanhamento do dente decíduo tratado, acredita-se que o MTA possa ter um grande potencial biológico e futuramente podendo transformar-se em uma opção de material para ser utilizado como rotina nas pulpotomias de dentes decíduos.

Several medicines have been tested and used in the conservative pulp therapy of deciduous teeth, however, the formocresol has being the elected material in the pulpotomies, even not assisting the biocompatibility demands and promoting the fixation of the vital pulp tissue and not its repair. After Mineral Trioxide Aggregate (MTA) appearance as a material with physico-chemical properties that promotes the tissue repair, allied to other important properties, such as the antimicrobial action and the biocompatibility to the pulpal tissues, a new alternative material appeared for the dentistry. The aim of this study was to report the effect of MTA in a pulpotomy of deciduous molar, and its 1-year follow-up. The pulpotomy was made with MTA in the tooth 85 in a 5-year-old patient. The results obtained were quite favorable, demonstrating clinical and radiographic success, as well as absence of painful symptomatology reported by the patient. In spite of the little time of follow-up of the treated deciduous tooth, MTA has a great biological potential and could be an alternative material to be used in the pulpotomies of deciduous teeth.

https://doi.org/10.1590/1981-863720140004000015978 3651 downloads

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