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Abstract Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.

https://doi.org/10.1590/0001-3765202220211590

Structure and Absolute Configuration of Secondary Metabolites from Two Strains of Streptomyces chartreusis Associated with Attine Ants
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Ortega, Humberto E.

; Batista Jr., João M.

; Melo, Weilan G. P.

; Paula, Gabriela T. de

; Pupo, Mônica T.

Journal of the Brazilian Chemical Society

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dec 2019, Volume 30 N. 12 Pages 2672 - 2680

Abstract: En | Text: En | PDF: En

The antibiotic streptazolin (1), its E-isomer (2), along with the stereoisomers strepchazolin A (3) and strepchazolin B (4) and the inorganic compound cyclooctasulfur (5) were produced in solid culture by Streptomyces chartreusis ICBG377, which was isolated from the fungal garden of the leaf-cutter ant Acromyrmex subterraneus brunneus. This is the first time compound 2 is reported as a natural product. Compound 5, which showed antagonist activity against the specialized pathogenic fungus Escovopsis sp., was also produced by Streptomyces chartreusis ICBG323, isolated from the exoskeleton of winged male of Mycocepurus goeldii. The absolute configurations of 3 and 4 were confirmed by the combination of vibrational circular dichroism (VCD) spectroscopy and density functional theory (DFT) calculations. These results clearly demostrate the power of VCD to tell apart epimeric natural products. Compounds 1, 3 and 4 were produced by geographically distant but phylogenetically close strains, S. chartreusis ICBG 377 isolated in Brazil, and S. chartreusis NA02069, a marine sediment strain isolated in China.

https://doi.org/10.21577/0103-5053.20190194 340 downloads

Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats
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Paixão, Mônica S.

; Melo, Mônica S.

; Damascena, Nicole P.

; Araújo, Adriano A.S.

; Soares, Andrea F.

; Oliveira, Denise V.A.

; Oliveira, Jeison S.

; Almeida, Fabrício T.C.

; Amaral, Francilene S.

; Araújo, Brancilene S.

; Estevam, Charles S.

; Botelho, Marco A.

; Quintans-Júnior, Lucindo J.

Revista Brasileira de Farmacognosia

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feb 2015, Volume 25 N. 1 Pages 35 - 41

Abstract: En | Text: En | PDF: En

Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5% (GS5%) and 10% (GS10%), comparing their effects with doxycycline gel at 10% (D10%, positive control), vehicle gel (negative control) and a group with experimental periodontal disease, but non-treated. The gels were locally applied in the gingival region immediately after the experimental periodontal disease induction by ligature (3×/day, 11 days). Bone destruction was determined through clinical exam, histopathological analysis and cone beam computed tomography of the experimental animals (n = 36). After 11 days of periodontitis induction, all groups that received ligature presented a decrease in the corporal mass, except to the naïve group (without experimental periodontal disease) (p < 0.05). Computed tomography results have shown healthy bone structure in the group I and bone resorption for the test groups. Histopathological analysis confirmed the healthy bone structure for naïve group animals, while the test groups exhibited bone loss in several degrees. In particular, the non-treated group animals had an intense inflammatory process. When the periodontium of the animals treated with GS10% was histopathologically analyzed, insertion periodontium was preserved. The results for these groups were significantly different of the vehicle group (p < 0.05). According to the results, the gel based in the aqueous extract of H. pectinata at 10% can prevent bone loss in experimental periodontal disease similarly to doxycycline 10%.

https://doi.org/10.1016/j.bjp.2014.12.002 1330 downloads

II Diretriz de Ressonância Magnética e Tomografia Computadorizada Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia
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Sara, Leonardo

; Szarf, Gilberto

; Tachibana, Adriano

; Shiozaki, Afonso Akio

; Villa, Alexandre Volney

; Oliveira, Amarino Carvalho de

; Albuquerque, Andrei Skromov de

; Rochitte, Carlos Eduardo

; Nomura, César Higa

; Azevedo, Clerio Francisco

; Jasinowodolinski, Dany

; Tassi, Eduardo Marinho

; Medeiros, Fabio de Morais

; Kay, Fernando Uliana

; Junqueira, Flávia Pegado

; Azevedo, Guilherme S. A.

; Monte, Guilherme Urpia

; Pinto, Ibraim Masciarelli Francisco

; Gottlieb, Ilan

; Andrade, Joalbo

; Lima, João A. C.

; Parga Filho, José Rodrigues

; Kelendjian, Juliana

; Fernandes, Juliano Lara

; Iquizli, Leonardo

; Correia, Luis C. L.

; Quaglia, Luiz Augusto

; Gonçalves, Luiz Flavio Galvão

; Ávila, Luiz Francisco

; Zapparoli, Marcello

; Hadlich, Marcelo

; Nacif, Marcelo Souto

; Barbosa, Márcia de Melo

; Minami, Márcio Hiroshi

; Bittencourt, Marcio Sommer

; Siqueira, Maria Helena Albernaz

; Silva, Marly Conceição

; Lopes, Marly Maria Uellendahl

; Marques, Mateus Diniz

; Vieira, Mônica La Rocca

; Coellho Filho, Otávio Rizzi

; Schvartzman, Paulo R.

; Santos, Raul D.

; Cury, Ricardo C.

; Loureiro, Ricardo

; Cury, Roberto Caldeira

; Sasdelli Neto, Roberto

; Macedo, Robson

; Cerci, Rodrigo Julio

; Faria Filho, Rui Alberto de

; Cardoso, Sávio

; Naves, Thiago

; Magalhães, Tiago Augusto

; Senra, Tiago

; Burgos, Ursula Maria Moreira Costa

; Moreira, Valéria de Melo

; Ishikawa, Walther Yoshiharu

Arquivos Brasileiros de Cardiologia

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dec 2014, Volume 103 N. 6 Pages 1 - 86

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.2014S006 67586 downloads

Quality of papaya hybrid grown under different irrigation depths
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Silva, Mônica S. da

; Melo, Alberto S. de

; Pedroza, Juarez P.

; Gomes, Josivanda P.

; M. Júnior, Sebastião de Oliveira

Engenharia Agrícola

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aug 2013, Volume 33 N. 4 Pages 865 - 875

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A irrigação é uma prática muito utilizada na fruticultura no Nordeste brasileiro, inclusive no cultivo do mamoeiro, a fim de aumentar sua produtividade. Desejando-se conhecer o potencial produtivo de híbridos de mamoeiro irrigado, realizou-se experimento com o objetivo de avaliar a qualidade de frutos de mamoeiro (Carica papaya L.) híbrido em função de diferentes lâminas de irrigação. Foram testadas quatro lâminas de irrigação (50; 75; 100 e 125% da ETo), sendo a evapotranspiração de referência calculada pelo modelo de Penman-Monteith. Utilizou-se o mamoeiro UENF/Caliman 01, que foi plantado em fileiras simples, sendo o plantio realizado no espaçamento de 4 m x 2 m, irrigado por gotejamento. O delineamento experimental foi em blocos ao acaso, com seis repetições e três plantas úteis por parcela. As variáveis estudadas foram: diâmetro transversal, diâmetro longitudinal, espessura da polpa, aparências externa e interna, sólidos solúveis, acidez titulável, pH e relação sólidos solúveis/acidez titulável. Os maiores diâmetros transversal e longitudinal dos frutos foram obtidos nas lâminas de irrigação de cerca de 108% da evapotranspiração. O híbrido UENF/Caliman 01 pode ser cultivado na região do sertão paraibano com taxa de reposição de 100% da ETo, sem comprometer a qualidade dos frutos.

Irrigation is a practice widely used in fruit production in the Brazilian Northeast region, including in the papaya crop in order to increase their productivity. For the purpose of knowing the productive potential of papaya hybrid irrigated, an experiment was carried out in order to evaluate the performance of a papaya hybrid under different irrigations depths. Four irrigation depths (50, 75, 100 and 125% of ETo) were tested and the reference evapotranspiration was calculated by the Penman-Monteith model. The hybrid papaya used was UENF/Caliman 01, which was planted in single rows, spaced 4 x 2m from each other, and irrigated by dripping. The experimental design in randomized blocks was used with six replications and three plants per plot. The following variables were evaluated: transversal diameter, longitudinal diameter, pulp thickness, external and internal appearances, soluble solids, titratable acidity, pulp pH and soluble solids/titratable acidity relation. The higher transversal and longitudinal diameters of the fruit were obtained applying an irrigation depth of about 108% of evapotranspiration. The UENF/Caliman 01 hybrid can be cultivated in the semiarid region of the State of Paraiba, Brazil, with replacement rate of 100% ETo, without compromising the quality of the fruits.

1614 downloads

Quantitative assessment of S. mutans and C. albicans in patients with Haas and Hyrax expanders
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Pithon, Matheus Melo

; Santos, Rogério Lacerda dos

; Alviano, Wagner Sales

; Ruellas, Antonio Carlos de Oliveira

; Araújo, Mônica Tirre de Souza

Dental Press Journal of Orthodontics

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jun 2012, Volume 17 N. 3 Pages e1 - e6

Abstract: En | Text: En | PDF: En

OBJECTIVE: To assess and compare the number of Streptococcus mutans and Candida albicans colonies in patients with Haas and Hyrax appliances before and after insertion. METHODS: The sample consisted of 84 patients requiring orthodontic treatment. For all patients a midpalatal suture expansion was indicated. Patients were randomly divided into Group HA, who used the Haas appliance (n = 42) and Group HY, who used the Hyrax appliance (n = 42). Initially and thirty days after appliance insertion all patients were submitted to saliva collections. The saliva was diluted followed by seeding in Mitis Salivarius and CHROMagar media, for growth of S. mutans and C. albicans respectively. RESULTS: Results showed statistically significant difference between groups HA and HY for Streptococcus mutans and Candida albicans (p <0.05). Haas appliance promoted greater S. mutans and C. albicans proliferation when compared to Hyrax appliance. CONCLUSION: The Haas appliance favored greater proliferation of S. mutans and C. albicans when compared with the Hyrax appliance. Insertion of the appliances resulted in greater buildup of microorganisms.

2934 downloads

Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil
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Lima, Gabrielle M.

; Quintans-Júnior, Lucindo J.

; Thomazzi, Sara M.

; Almeida, Emyle M. S. A.

; Melo, Mônica S.

; Serafini, Mairim R.

; Cavalcanti, Sócrates C. H.

; Gelain, Daniel P.

; Santos, João Paulo A.

; Blank, Arie F.

; Alves, Péricles B.

; Oliveira Neta, Paulina M.

; Lima, Julianeli T.

; Rocha, Ricardo F.

; Moreira, José Claúdio F.

; Araújo, Adriano A. S.

Revista Brasileira de Farmacognosia

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apr 2012, Volume 22 N. 2 Pages 443 - 450

Abstract: En | Text: En | PDF: En

Chrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. The present study evaluated the antinociceptive and anti-inflammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identified as khusimol (19.57%), E-isovalencenol (13.24%), α-vetivone (5.25%), β-vetivone (4.87%) and hydroxy-valencene (4.64%). Following intraperitoneal injection (i.p.), EO at 50 and 100 mg/kg significantly reduced the number of writhes (51.9 and 64.9%, respectively) and the number of paw licks during phase 2 (56.7 and 86.2%, respectively) of a formalin model when compared to control group animals. However, EO-treated mice were ineffective at all doses in hot-plate and rota-rod tests. The EO inhibited the carrageenan-induced leukocyte migration to the peritoneal cavity in a dose-dependent manner (34.7, 35.4, and 62.5% at doses of 25, 50 and 100 mg/kg, respectively). In the paw edema test, the EO (100 mg/kg) inhibited all three phases of the edema equally well, suggesting that the EO has a non-selective inhibitory effect on the release or actions of these mediators. Our results suggest possible antinociceptive and anti-inflammatory effects of the EO.

4212 downloads

p-Cymene reduces orofacial nociceptive response in mice
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Santana, Michele F.

; Quintans-Júnior, Lucindo J.

; Cavalcanti, Sócrates C. H.

; Oliveira, Makson G. B.

; Guimarães, Adriana G.

; Cunha, Edisleide S.

; Melo, Mônica S.

; Santos, Márcio R. V.

; Araújo, Adriano A. S.

; Bonjardim, Leonardo R.

Revista Brasileira de Farmacognosia

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dec 2011, Volume 21 N. 6 Pages 1138 - 1143

Abstract: En | Text: En | PDF: En

This study investigated the possible antinociceptive effect of p-cymene in different tests of orofacial nociception. The animals (mice) were pretreated (i.p.) with p-cymene (25, 50, 100 mg/kg), morphine (5 mg/kg), or vehicle (0.2% Tween 80+saline), and were then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, and glutamate. The nociceptive behavior response was characterized by the time in s that the mice remained rubbing the orofacial region, for a period of 40 min in the formalin test (first phase, 0-6 min; and second phase, 21-40 min), and for 42 and 15 min in the capsaicin and glutamate tests, respectively. To verify the possible opioid involvement in the antinociceptive effects, naloxone (i.p.) was administered into the mice 15 min prior to the pretreatment with p-cymene (100 mg/kg). Finally, whether or not the p-cymene evoked any change in motor performance in the Rota-rod test was evaluated. The results showed that the treatment with p-cymene, at all doses, reduced (p<0.001) the nociceptive behavior in all nociception tests. The antinociceptive effect of p-cymene was antagonized by naloxone (1.5 mg/kg). Additionally, mice treated with p-cymene did not show any change in motor performance. In conclusion, p-cymene attenuated orofacial nociception, suggesting an involvement of the opioid system in this effect. Thus, p-cymene might represent an important biomolecule for management and/or treatment of orofacial pain.

2936 downloads

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach
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Venâncio, Antônio M.

; Marchioro, Murilo

; Estavam, Charles S.

; Melo, Mônica S.

; Santana, Marília T.

; Onofre, Alexandre S.C.

; Guimarães, Adriana G.

; Oliveira, Makson G. B.

; Alves, Péricles B

; Pimentel, Hugo de Carvalho

; Quintans-Júnior, Lucindo J.

Revista Brasileira de Farmacognosia

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dec 2011, Volume 21 N. 6 Pages 1043 - 1051

Abstract: En | Text: En | PDF: En

The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.

4359 downloads

10.

Bioassay-guided evaluation of central nervous system effects of citronellal in rodents
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Melo, Mônica S.

; Santana, Marilia T. de

; Guimarães, Adriana G.

; Siqueira, Rosana S.

; Sousa, Damião P. De

; Santos, R. V.

; Bonjardim, Leonardo R.

; Araújo, Adriano A. S.

; Onofre, Alexandre S. C.

; Lima, Julianeli T.

; Almeida, Jackson R. G. S.

; Quintans-Júnior, Lucindo J.

Revista Brasileira de Farmacognosia

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aug 2011, Volume 21 N. 4 Pages 697 - 703

Abstract: En | Text: En | PDF: En

The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABA A receptor. These results suggest a possible CNS depressant and anticonvulsant activities.

2443 downloads

11.

Anticonvulsant evaluation of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, in rodents
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Quintans-Júnior, Lucindo J.

; Siqueira, Jullyana S.

; Melo, Mônica S.

; Silva, Davi A.

; Morais, Liana C. S. L.

; Souza, Maria de Fátima V.

; Almeida, Reinaldo N.

Revista Brasileira de Farmacognosia

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mar 2010, Volume 20 N. 1 Pages 54 - 59

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo buscou avaliar os efeitos do extrato etanólico das raízes de Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, (EER) e sua possível atividade anticonvulsivante em roedores. No teste das convulsões induzidas pelo pentilenotetrazol (PTZ) os animais tratados com EER, 250 mg/kg (i.p.), apresentaram aumento significativo (p<0,05) da latência para o aparecimento das convulsões (328,9±47,5) quando comparado aos do grupo controle (103,5±21,8) e reduziu o número de óbitos. Esse efeito foi bloqueado pela administração do flumazenil. O EER produziu aumento significativo (p<0,05) na latência nos testes da picrotoxina (PIC) e da estricnina (EST), nas maiores doses. No modelo do eletrochoque auricular o EER não produziu alterações significativas em nenhum dos parâmetros avaliados. Entretanto, no modelo do abrasamento induzido pelo PTZ, a administração com o EER produziu um efeito protetor, atenuando de forma significativa (p<0,05) o desenvolvimento e a severidade das crises convulsivas. Os resultados, sugerem que o EER induziu efeito anticonvulsivante em roedores e que o sistema GABAérgico pode estar envolvido nessa resposta.

The Aim of this study was to evaluated the effects of the ethanol extract of Rauvolfia ligustrina Willd. ex Roem. & Schult., Apocynaceae, roots (EER) in animal models of epilepsy. The EER increased the latency for convulsions significantly different from control (p<0,05) and in the PTZ induced convulsions test on 62,5 mg/kg (i.p.) decreased mortality. This effect was blocked by flumazenil administration, suggesting an involvement of GABAergic system in the anticonvulsant activity of EER. The EER had a moderate effect only against PIC- or STR-induced convulsions at doses 125 and 250 mg/kg. But in the MES test it did not demonstrate effect on this animal model. Therefore, the EER reduced the development of PTZ-induced kindling in both experimental groups. It also significantly (p<0.05) decreased the latency for convulsions and reduced its percentage. Our results suggest that EER owns anticonvulsant property.

2123 downloads

12.

Antinociceptive and anti-inflammatory effects of the essential oil of Eugenia candolleana DC., Myrtaceae, on mice
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Guimarães, Adriana G.

; Melo, Mônica S.

; Bonfim, Rangel R.

; Passos, Luiz O.

; Machado, Samísia M.F.

; Ribeiro, Adauto de S.

; Sobral, Marcos

; Thomazzi, Sara M.

; Quintans-Júnior, Lucindo J.

Revista Brasileira de Farmacognosia

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dec 2009, Volume 19 N. 4 Pages 883 - 887

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Eugenia candolleana DC. (Myrtaceae), conhecida popularmente como "murta" ou "murtinha", é uma espécie vegetal sem estudos químicos e farmacológicos descritos na literatura, distribuída no Nordeste brasileiro, principalmente, na Zona da Mata. Na medicina popular do Estado de Sergipe é utilizada no tratamento de distúrbios febris e da dor. O presente estudo buscou avaliar as possíveis atividades antinociceptiva e antiinflamatória do óleo essencial extraído das folhas de E. candolleana DC (OEEc) em roedores. A administração intraperitoneal (i.p.) do OEEc (25, 50 e 100 mg/kg) reduziu significativamente o número de contorções no teste das contorções abdominais e a duração da lambida da pata na segunda fase do teste da formalina (p < 0,001). Entretanto, a administração do OEEc não alterou o tempo de reação no teste da placa quente. No experimento de peritonite induzido por carragenina, o OEEc reduziu de forma significativa (p < 0,01) a migração de leucócitos para a cavidade peritoneal. Os resultados obtidos sugerem que o OEEc possui ação antinociceptiva, provavelmente mediado por mecanismos periféricos, e ação antiinflamatória.

Eugenia candolleana DC. (Myrtaceae), commonly known as "murta" or "murtinha", is a plant species without any chemical or pharmacological study described in the literature. It has been popularly used for the treatment of pain and fever. This report aimed to investigate the possible antinociceptive and anti-inflammatory effects of the essential oil extracted from fresh leaves of Eugenia candolleana DC. (EOEc) in rodents. Following intraperitoneal injection, EOEc (25, 50 and 100 mg/kg) reduced the number of writhes significantly in a writhing test and the number of paw licks during phase two of formalin test (p < 0.001). However, administration of EOEc did not alter the time of reaction in hot plate test. Furthermore, EOEc inhibited (p < 0.01) the carrageenan-induced leukocyte migration to the peritoneal cavity. These results indicate antinociceptive and anti-inflammatory properties of EOEc probably mediated via inhibition of prostaglandin synthesis or other peripherally pathway.

2925 downloads

13.

P53 gene deletion in multiple myeloma
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Ortega, Manoela M.

; Melo, Mônica B.

; Souza, Cármino A. de

; Lorand-Metze, Irene

; Costa, Fernando F.

; Lima, Carmen S. P.

Revista Brasileira de Hematologia e Hemoterapia

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jun 2003, Volume 25 N. 2 Pages 131 - 132

Abstract: En | Text: En | PDF: En

1449 downloads

14.

Melanoma maligno da mucosa nasossinusal: revisão da literatura e relato de dois casos
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Guimarães, Roberto E. S.

; Becker, Helena M. G.

; Ribeiro, Carlos A.

; Crossara, Paulo F. B. T.

; Brum, Luís R. A.

; Melo, Mônica M. O.

Revista Brasileira de Otorrinolaringologia

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jan 2003, Volume 69 N. 1 Pages 131 - 135

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O melanoma maligno da mucosa nasossinusal é um tumor indubitavelmente raro e agressivo que acomete pacientes acima dos sessenta anos e não tem associação com o sexo. A obstrução nasal e a epistaxe são os sintomas mais freqüentemente relatados, embora a sintomatologia seja tardia e inespecífica, o que retarda o diagnóstico e piora o prognóstico. A abordagem tradicional tem sido o tratamento cirúrgico; a radioterapia é também utilizada, entretanto sua eficácia ainda é discutida. O objetivo desse trabalho é relatar dois casos da doença em mucosa nasossinusal e realizar uma revisão da literatura sobre o assunto.

Malignant melanoma of the sinonasal mucosa is undoubtedly a rare and aggressive tumor, which affects patients over sixty years of age and is not associated with gender. Nasal obstruction and epistaxis are the most frequently reported symptoms, although the presentation is late and unspecific, which delays the diagnosis and worsens the prognosis. The traditional approach has been surgical treatment; radiotherapy has also been used; however its effectiveness remains uncertain. The purpose of the present study is to report two cases of malignant melanoma of the sinonasal mucosa and present a literature review.

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Extreme resistance to two Brazilian strains of Potato virus Y (PVY) in transgenic potato, cv. Achat, expressing the PVYº coat protein
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Romano, Eduardo

; Ferreira, Adriana T.

; Dusi, André N.

; Proite, Karina

; Buso, Jose A.

; Ávila, Antonio C.

; Nishijima, Marta L.

; Nascimento, Adriana S.

; Bravo-Almonacid, Fernando

; Mentaberry, Alejandro

; Monte, Damares

; Campos, Magnólia A.

; Melo, Paulo Eduardo

; Cattony, Monica K.

; Torres, Antonio C.

Horticultura Brasileira

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jul 2001, Volume 19 N. 2 Pages 118 - 122

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O gene da capa protéica (CP) do Potato virus Y estirpe "o", foi introduzido em batata cultivar Achat, via Agrobacterium tumefaciens. Sessenta e três linhas possivelmente transgênicas foram desafiadas com as estirpes brasileiras PVY-OBR e PVY-NBR. Uma linha apresentou extrema resistência às duas estirpes inoculadas, e foi denominado clone 1P. Não foram observados sintomas sistêmicos de infecção e as plantas foram negativas em Elisa. Outra linha, denominada clone 63P, mostrou algum nível de resistência. Análises por Southern blot indicaram a presença de pelo menos cinco cópias do gen CP no clone 1P e pelo menos três cópias no clone 63P. A estabilidade do gene introduzido no clone 1P foi avaliada durante três anos, após várias multiplicações in vitro. Não foram observadas mudanças no padrão do Southern blot. A estabilidade do transgene, na ausência de infecções primárias e relativo largo espectro de resistência sugerem que o clone 1P pode ser utilizado para fins comerciais.

The coat protein (CP) gene of the potato virus Y strain "o" (PVY O) was introduced into potato, cultivar Achat, via Agrobacterium tumefaciens-mediated transformation. Sixty three putative transgenic lines were challenged against the Brazilian strains PVY-OBR and PVY-NBR. An extremely resistant phenotype, against the two strains, was observed in one line, denominated 1P. No symptoms or positive ELISA results were observed in 16 challenged plants from this line. Another clone, named as 63P, showed a lower level of resistance. Southern blot analysis showed five copies of the CP gene in the extremely resistant line and at least three copies in the other resistant line. The stability of the integrated transgenes in the extreme resistant line was examined during several in vitro multiplications over a period of three years, with no modification in the Southern pattern was observed. The stability of the transgenes, the absence of primary infections and the relatively broad spectrum of resistance suggest that the extremely resistant line obtained in this work can be useful for agricultural purposes.

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