Early career researchers at African universities face numerous challenges and demands within a context of minimum resources; yet on the other hand, there is significant expectation for doing excellent science that is of high quality with integrity, while aligning science with societal goals. Furthermore, there is also expectation to increase outputs, make the system more inclusive, attract international partners and contribute to the University's global rankings. The need therefore to build research capacity, expand the number of active researchers and advance the careers of African researchers has never been more critical, particularly if continental and other global priorities are to be achieved. There is consensus that research leadership is essential to building research capacity in African universities. As a result, there have been increasing investments in building research capacity and research leadership, with initiatives ranging from the creation of north-south research partnerships across disciplines and empirical subjects, to training research leaders and university administrators in top ranking universities in Europe and North America, as well as building the capacity of funders and science systems in Africa. This article will examine the competencies required to be a research leader and the programs that are currently available that support capacity building in research leadership. In addition, it will provide perspectives on the role that global and African funders should play to advance the careers of early career researchers to transition into research leaders, foster innovation, build linkages with policy makers and promote scientific leadership in Africa.

The aim of this study was to compare the effects of cryopreservation at approximately -196 ºC in liquid nitrogen (N) and freezing at approximately -20 ºC in a freezer, on the viability and survival of eight different mastitogenic bacteria inoculated in milk. Bacteria were frozen at approximately -20 ºC in a freezer and cryopreserved at approximately -196 ºC in liquid nitrogen. An effective preservation method was needed for follow-up samples from cows identified in the South African National Milk Recording Scheme (NMRS) with somatic cell counts above 250 000 cells/mL milk. The organisation responsible for sample collection of the NMRS milk samples also provides producers with liquid nitrogen for their semen flasks at the collection sites. This existing mode of storage and transport could therefore be utilised. Ten samples of each organism were thawed and cultured bi-weekly until week 18 for both temperature treatments. An additional sampling was performed at week 30 for samples frozen at approximately -20 ºC. Freezing and cryopreservation did not impair subsequent isolation of Streptococcus dysgalactiae, Streptococcus uberis, Enterococcus faecalis, Staphylococcus aureus (STH) (phage type lytic group III) or Sta. aureus (STA) (phage typed, other than lytic group III). Survival was indicated by the isolation of bacteria from samples, and viability by the strength of growth of the bacteria isolated. The survival of Streptococcus agalactiae decreased after week 12 and Escherichia coli after week 16 of freezing, but both organisms survived under cryogenic preservation until week 18. Coagulase-negative staphylococci survived until week 18 for both freezing and cryogenic preservation. Both storage methods could thus contribute to the improvement of a pro-active approach towards udder health management in South African dairy herds.

Large scale Monte Carlo simulations have been used to study long-time domain growth behavior in a compressible, two-dimensional Ising model undergoing phase separation. The system is quenched below the transition temperature from a random spin state, and we investigated the late-time domain size growth law, R(t) = A + Bt n. For "lattice mismatched" systems, we found n = 0.224 ± 0.004 which deviates significantly from the Lifshitz-Slyozov value of n = 1/3 for late-time growth . For a compressible model with no mismatch, we find only a slight deviation from n = 1/3. These results strongly suggest that we do not yet fully understand domain growth.

Drug delivery system controls the distribution of drugs for optimal therapeutic efficacy. The complex of higly active drugs with macromolecular carriers seems to offer a promising way to optimize their delivery. Dendrimers can be used as drug delivery system and this paper addresses the effectivenes of the approach. The host-guest system improves the solubility of hydrazides and mesoionic 1,3,4-thiadiazolium-2-aminide compounds.

The apical membrane antigen (AMA-1) family of malaria merozoite proteins is characterised by a high degree of inter-species conservation. Evidence that the protein (PK66/AMA-1) from the simian parasite Plasmodium knowlesi was protective in rhesus monkeys suggested that the 83kDa P. falciparum equivalent (PF83/AMA-1) should be investigated for protective effects in humans. Here we briefly review pertinent comparative data, and describe the use of an eukaryotic full length recombinant PF83/AMA-1 molecule to develop a sensitive ELISA for the determination of serological responses in endemic populations. The assay has revealed surprisingly high levels of humoral response to this quantitatively minor antigen. We also show that PK66/AMA-1 inhibitory mAb's are active against merozoites subsequent to release from schizont-infected red cells, further implicating AMA-1 molecules in red cell invasion.