RESUMO Objetivo: Avaliar a frequência dos sintomas oftalmológicos, neurológicos e sistêmicos mais comuns em pacientes sintomáticos atendidos no serviço de triagem de COVID-19 do Hospital das Clínicas da UFPE. Métodos: Cento e quatro pacientes com suspeita clínica de infecção por Sars-Cov-2 foram submetidos a avaliação médica e aplicação de questionário sobre a sintomatologia oftalmológica, neurológica e sistêmica. Todos os participantes do estudo tiveram exame de RT-PCR para COVID-19 solicitado. Resultados: A média de idade foi de 38,8 anos, com 44,23% entre 31 e 40 anos. Mulheres corresponderam a 68,27% dos atendimentos e homens a 31,73%. Os sintomas mais frequentes nos pacientes com RT-PCR positivo foram: tosse (69,23%), febre (42,3%), mialgia (38,46%), hiposmia (38,46%), e ageusia (30,77%). Neste grupo, os sintomas oftalmológicos estiveram presentes em 34,61%, sendo: ardor (19,23%), dor ocular (11,54%), sensação de corpo estranho (7,7%), hiperemia (7,7%) e lacrimejamento (3,84%) os mais encontrados. Conclusões: O quadro clínico sistêmico foi característico de infecção respiratória alta, porém os achados neurológicos de hiposmia e anosmia mostraram-se importantes marcadores para a suspeição dos casos de infecção por COVID-19. Os sintomas oftalmológicos dos pacientes com COVID-19 foram semelhantes aos presentes em outros quadros virais, podendo preceder o quadro sistêmico. Houve uma alta taxa de automedicação para os sintomas gerais quando comparado ao quadro oftalmológico.

ABSTRACT Purpose: This study evaluated the frequency of the most common ophthalmological, neurological, and systemic findings in symptomatic patients seen at a COVID-19 screening service at Hospital das Clínicas - Universidade Federal de Pernambuco. Methods: A total of 104 patients under clinical suspicion of SARS-CoV-2 infection underwent medical evaluation through an ophthalmological and systemic symptoms survey. All participants selected for the study underwent COVID-19 RT-PCR testing. Results: The mean age was 38.8 years, with 44.23% between 31 and 40 years old, 68.27% female, and 31.73% male. The most common symptoms in patients with a positive RT-PCR test were cough (69.23%), fever (42.3%), hyposmia (38.46%), myalgia (38.46%), and ageusia (30.77%). In the positive group, 34.61% presented with ophthalmological symptoms: burning (19.23%), eye pain (11.54%), foreign body sensation (7.7%), hyperemia (7.7%), and tearing (3.84%). Conclusions: Systemic clinical features were characteristic of upper respiratory infection, but neurological findings of hyposmia and anosmia proved to be important markers for suspicion of SARS-CoV-2 infection. Ophthalmic symptoms in patients with COVID-19 were similar to those observed in other viral conditions and may precede systemic conditions. A high rate of self-medication was observed for general symptoms compared with ophthalmological conditions.

OBJECTIVES: To retrospectively evaluate the performance and distinctive pattern of latent tuberculosis (TB) infection (LTBI) screening and treatment in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) under anti-tumor necrosis factor (TNF) therapy and determine the relevance of re-exposure and other risk factors for TB development. METHODS: A total of 135 and 83 patients with AS and PsA, respectively, were evaluated for LTBI treatment before receiving anti-TNF drugs via the tuberculin skin test (TST), chest radiography, and TB exposure history assessment. All subjects were evaluated for TB infection at 3-month intervals. RESULTS: The patients with AS were more often treated for LTBI than were those with PsA (42% versus 30%, p=0.043). The former also presented a higher frequency of TST positivity (93% versus 64%, p=0.002), although they had a lower frequency of exposure history (18% versus 52%, p=0.027) and previous TB (0.7% versus 6%, p=0.03). During follow-up [median, 5.8 years; interquartile range (1QR), 2.2-9.0 years], 11/218 (5%) patients developed active TB (AS, n=7; PsA, n=4). TB re-exposure was the main cause in seven patients (64%) after 12 months of therapy (median, 21.9 months; IQR, 14.2-42.8 months) and five LTBI-negative patients. TB was identified within the first year in four patients (36.3%) (median, 5.3 months; IQR, 1.2-8.8 months), two of whom were LTBI-positive. There was no difference in the TB-free survival according to the anti-TNF drug type/class; neither synthetic drug nor prednisone use was related to TB occurrence (p>0.05). CONCLUSION: Known re-exposure is the most critical factor for incident TB cases in spondyloarthritis. There are also some distinct features in AS and PsA LTBI screening, considering the higher frequency of LTBI and TST positivities in patients with AS. Annual risk reassessment taking into consideration these peculiar features and including the TST should be recommended for patients in endemic countries.

Resumo O texto aborda a participação de Machado de Assis nos festejos pela Abolição – missa, cortejos e poesia –, estando também entre aqueles que produziram uma memória para o grande feito do 13 de maio: o fim da escravidão. Se os relatos sobre a Abolição tratam sempre de um "delírio" machadiano, nem sempre abordam as diferentes funções desse literato para o processo, tendo sido funcionário público desde 1873, cargo em que atuou pela liberdade dos escravos, e, em 1888, também um intérprete da abolição, através das crônicas e poesias. As festas da Abolição ficariam na memória desse literato que nos anos seguintes usou esse "dia de delírio" para comentar o seu presente republicano e o futuro das festas da Abolição.

Abstract The text addresses Machado de Assis’s participation in the Abolition celebrations – mass, courtship, and poetry – as he was among those who created a memory for the great feat of May 13: the end of slavery. Although the reports about Abolition always discuss a Machadian "delirium," they do not always address the different roles this literary figure played in the process, as he had been a civil servant since 1873, where he worked for the freedom of slaves, and in 1888, as an interpreter of abolition through chronicles and poetry. The festivals of abolition would be in the memory of this writer who in the following years used this "day of delirium" to comment on his Republican gift and the future of the Abolition celebrations.

A abolição da escravidão no Brasil, em maio de 1888, não envolveu apenas literatos, políticos, jornalistas e a família imperial, mas também, trabalhadores, abolicionistas e moradores dos subúrbios da província do Rio de Janeiro e de locais mais afastados. A participação desses foi marcada, por exemplo, pela subscrição popular realizada nas vésperas da Abolição e apoiada por um jornal, O Paiz, no intuito de comprar a pena de ouro a ser utilizada pela princesa regente no momento da assinatura da lei. A oferta do dinheiro foi feita por meio de doações individuais ou coletivas em que se depositaram também as expectativas em torno do fim da escravidão e os sentidos de liberdade mais amplos associados à Abolição. Os outros festejos promovidos pela imprensa são fundamentais para entendermos a mediação desses sentidos feita por ela.

The abolition of slavery in Brazil on May 1888 involved not only writers, politicians, journalists and the imperial family, but also workers, abolitionists and people who lived in distant neighborhoods of Rio de Janeiro and other even farther places. The participation of these people was highlighted, for instance, by the popular money collection supported by a newspaper named O Paiz on the eve of the Abolition. The purpose of such collection was the purchase of a feather-shaped gold pen to be used by the Princess Regent on the occasion of the signing of the law. The money was offered by individual and collective donations in which the expectations about the end of slavery and the deepest senses of freedom associated to the Abolition were also present. The other celebrations promoted by the press are essential to understand the explanations it offered about those meanings.