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Resumo Fundamento A síndrome de takotsubo (takotsubo) é uma forma de cardiomiopatia adquirida. Dados nacionais sobre essa condição são escassos. O Registro REMUTA é o primeiro a incluir dados multicêntricos dessa condição no nosso país. Objetivo Descrever as características clínicas, prognóstico, tratamento intra-hospitalar e mortalidade hospitalar e em 1 ano de seguimento. Métodos Estudo observacional, retrospectivo, tipo registro. Incluídos pacientes internados com diagnóstico de takotsubo ou que desenvolveram esta condição durante internação por outra causa. Os desfechos avaliados incluíram fator desencadeador, análise dos exames, uso de medicações, complicações e óbito intra-hospitalar e em 1 ano de seguimento. O nível de significância adotado foi de 5%. Resultados Foram incluídos 169 pacientes, em 12 centros no Estado do Rio de Janeiro. A idade média foi de 70,9 ± 14,1 anos e 90,5% eram do sexo feminino; 63% dos casos foram de takotsubo primário e 37% secundário. Troponina I foi positiva em 92,5% dos pacientes e a mediana de BNP foi de 395 (176,5; 1725). Supradesnivelamento do segmento ST esteve presente em 28% dos pacientes. A fração de ejeção do ventrículo esquerdo teve mediana de 40 (35; 48)%. Observamos taxa de 25,7% de ventilação mecânica invasiva e 17,4% de choque. Suporte circulatório mecânico foi utilizado em 7,7%. A mortalidade intra-hospitalar foi de 10,6% e a mortalidade ao final de 1 ano foi de 16,5%. Takotsubo secundário e choque cardiogênico foram preditores independentes de mortalidade. Conclusão Os resultados do REMUTA mostram que takotsubo não se trata de patologia benigna como se pensava, especialmente no grupo de takotsubo secundário que acarreta elevada taxa de complicações e de mortalidade. (Arq Bras Cardiol. 2020; 115(2):207-216)

Abstract Background Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil. Objective To describe the clinical characteristics, prognosis, in-hospital treatment, in-hospital mortality, and mortality during 1 year of follow-up. Methods This is an observational, retrospective registry study including patients admitted to the hospital with diagnosis of TTS and patients admitted for other reasons who developed this condition. Evaluated outcomes included triggering factor, analysis of exams, use of medications, complications, in-hospital mortality, and mortality during 1 year of follow-up. A significance level of 5% was adopted. Results The registry included 169 patients from 12 centers in the state of Rio de Janeiro, Brazil. Mean age was 70.9 ± 14.1 years, and 90.5% of patients were female; 63% of cases were primary TTS, and 37% were secondary. Troponin I was positive in 92.5% of patients, and median BNP was 395 (176.5; 1725). ST-segment elevation was present in 28% of patients. Median left ventricular ejection fraction was 40 (35; 48)%. We observed invasive mechanical ventilation in 25.7% of cases and shock in 17.4%. Mechanical circulatory support was used in 7.7%. In-hospital mortality was 10.6%, and mortality at 1 year of follow-up was 16.5%. Secondary TTS and cardiogenic shock were independent predictors of mortality. Conclusion The results of the REMUTA show that TTS is not a benign pathology, as was once thought, especially regarding the secondary TTS group, which has a high rate of complications and mortality. (Arq Bras Cardiol. 2020; 115(2):207-216)

https://doi.org/10.36660/abc.20190166 1217 downloads

Chitosan Nanoparticles Loaded with Carvacrol and Carvacryl Acetate for Improved Anthelmintic Activity
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André, Weibson P. P.

; Paiva Jr., José R.

; Cavalcante, Géssica S.

; Ribeiro, Wesley L. C.

; Araújo Filho, José V. de

; Cavalcanti, Bruno C.

; Morais, Selene M. de

; Oliveira, Lorena M. B. de

; Bevilaqua, Claudia M. L.

; Abreu, Flávia O. M. S.

Journal of the Brazilian Chemical Society

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aug 2020, Volume 31 N. 8 Pages 1614 - 1622

Abstract: En | Text: En | PDF: En

Carvacrol (CV) and carvacryl acetate (CVA) are bioactive compounds that have anthelmintic action and the nanoencapsulation may be an alternative to potentialize their efficacy. The aim of this work was to nanoencapsulate CV and CVA using chitosan/gums and evaluate cytotoxicity and the anthelmintic activity. A 24 factorial experimental design was performed to determine the influence of gum type (arabic or chichá), amount of surfactant and the number of layers in the nanoencapsulation degree. CVA and CV presented encapsulation efficiency (EE) optimum values of 90 and 20% (experiments 8 and 9), respectively. The monolayer and bilayer formulations presented maximum size of 479 and 811 nm, respectively. Nanoencapsulated CVA (nCVA) with bilayer coating and higher surfactant levels showed good thermal stability and no toxicity. In vitro kinetics for nCVA with chitosan/chichá gum showed slower release profiles than nCVA with chitosan/gum arabic, with 50% release after 30 and 20 h, respectively. CVA and nCVA at a concentration of 150 µg mL−1 reduced the motility of H. contortus adult nematodes by 100 and 91.7%, respectively. In summary, nCVA chitosan/chichá gum showed high encapsulation efficiency, favorable release rate and anthelmintic activity against H. contortus.

https://doi.org/10.21577/0103-5053.20200047 382 downloads

Computational prediction and characterisation of miRNAs and their pathway genes in human schistosomiasis caused by Schistosoma haematobium
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Cardoso, Thaís Cunha de Sousa

; de Araújo, Carlos Bruno

; Portilho, Laysa Gomes

; Mendes, Luiz Guilherme Alves

; Alves, Tamires Caixeta

; Silva, Gustavo Caetano

; Ribeiro, Thales Henrique Cherubino

; Gandolfi, Peterson Elizandro

; Morais, Enyara Rezende

; do Amaral, Laurence Rodrigues

; Gomes, Matheus de Souza

Memórias do Instituto Oswaldo Cruz

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2020, Volume 115 elocation e190378

Abstract: En | Text: En | PDF: En

BACKGROUND Key genes control the infectivity of the Schistosoma haematobium causing schistosomiasis. A method for understanding the regulation of these genes might help in developing new disease strategies to control schistosomiasis, such as the silencing mediated by microRNAs (miRNAs). The miRNAs have been studied in schistosome species and they play important roles in the post-transcriptional regulation of genes, and in parasite-host interactions. However, genome-wide identification and characterisation of novel miRNAs and their pathway genes and their gene expression have not been explored deeply in the genome and transcriptome of S. haematobium. OBJECTIVES Identify and characterise mature and precursor miRNAs and their pathway genes in the S. haematobium genome. METHODS Computational prediction and characterisation of miRNAs and genes involved in miRNA pathway from S. haematobium genome on SchistoDB. Conserved domain analysis was performed using PFAM and CDD databases. A robust algorithm was applied to identify mature miRNAs and their precursors. The characterisation of the precursor miRNAs was performed using RNAfold, RNAalifold and Perl scripts. FINDINGS We identified and characterised 14 putative proteins involved in miRNA pathway including ARGONAUTE and DICER in S. haematobium. Besides that, 149 mature miRNAs and 131 precursor miRNAs were identified in the genome including novel miRNAs. MAIN CONCLUSIONS miRNA pathway occurs in the S. haematobium, including endogenous miRNAs and miRNA pathway components, suggesting a role of this type of non-coding RNAs in gene regulation in the parasite. The results found in this work will open up a new avenue for studying miRNAs in the S. haematobium biology in helping to understand the mechanism of gene silencing in the human parasite Schistosome.

https://doi.org/10.1590/0074-02760190378 953 downloads

Aspectos epidemiológicos, clínico-patológicos e diagnóstico precoce da seneciose bovina no Oeste do Rio Grande do Sul
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Krabbe, Adriano A.

; Gonçalves, Maiara A.

; Silveira, Caroline S.

; Morais, Raissa M.

; Quevedo, Lucas S.

; Ribeiro, Paula V.R.

; Anjos, Bruno L.

Pesquisa Veterinária Brasileira

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dec 2017, Volume 37 N. 12 Pages 1423 - 1429

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A ingestão de Senecio spp. (maria-mole) é, possivelmente, a principal causa de morte de bovinos por agentes tóxicos nas regiões central e sul do Rio Grande do Sul. Ao considerar a limitação de informações acerca dessa condição no Oeste do Rio Grande do Sul, esse trabalho objetiva descrever os principais aspectos epidemiológicos e clínico-patológicos da seneciose em bovinos nessa região. O estudo foi realizado por meio da aplicação de questionários em 16 propriedades rurais de municípios da região que apresentaram casos suspeitos da intoxicação em bovinos, de agosto de 2011 a março de 2014. Durante as visitas as propriedades foram coletadas plantas do gênero Senecio para identificação botânica, bem como se procedeu a coleta de fragmentos de fígado através de biópsia transtorácica para confirmação da intoxicação. As espécies de Senecio mais frequentes nas propriedades foram S. brasiliensis e S. heterotrichius. De um total de 88 bovinos, de nove propriedades distintas, que apresentaram falha no ganho de peso, 69 animais (aproximadamente 80%) foram positivos para seneciose crônica por apresentarem lesões características da intoxicação, tais como fibrose periportal (78% dos casos), megalocitose (76% dos casos) e proliferação de ductos biliares (68% dos casos), classificadas entre discretas e acentuadas. O trabalho confirmou a ocorrência da doença, mesmo em bovinos sem sinais clínicos evidentes. Os resultados obtidos nessas avaliações foram fundamentais para orientar proprietários e técnicos quanto às principais características da doença e às formas de controle a serem adotadas. O emprego da biópsia hepática possibilitou o diagnóstico precoce da intoxicação e auxiliou os criadores quanto ao descarte mais criterioso de bovinos e a real situação da intoxicação no rebanho, minimizando as perdas econômicas.

ABSTRACT: The ingestion of Senecio spp. (ragwort) is perhaps the leading cause of death of cattle in central and southern Rio Grande do Sul, Brazil. Considering the limited information about this condition in the Western region of Rio Grande do Sul, Brazil, this paper describes main epidemiological clinical and pathological aspects of seneciosis in cattle. The assessments were made through questionnaires on 16 rural properties which had suspected cases of poisoning in cattle, from August 2011 to March 2014. During the visits were evaluated epidemiological aspects of poisoning and performed sample collection of Senecio plants for botanical identification, as well as collection of liver samples using transthoracic biopsy for confirmation of the poisoning. Senecio species most common on farms were S. brasiliensis and S. heterotrichius. From 88 cattle that failed to thrive on nine different farms, 69 animals (about 80%) were positive for chronic seneciosis with periportal fibrosis (78% of cases), megalocytosis (76% of cases) and with bile duct proliferation (68% of cases). Lesions were classified as mild, moderate or marked. The current study confirms the occurrence of this poisoning, even in cattle without evident clinical signs. The use of liver biopsy enabled the early diagnosis of poisoning and helped farmers carefully to dispose affectd cattle, as well as to recognize the real situation of poisoning in the herd and minimize economic losses.

https://doi.org/10.1590/s0100-736x2017001200011 1465 downloads

Nonfunctional overreaching and hepatic adaptations of APPL1 and APPL2
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Morais, Gustavo P.

; Vicente, Larissa Gaioto de

; Oliveira, Luciana da C.

; Pinto, Ana P.

; Rocha, Alisson L. da

; Pereira, Bruno C.

; Pauli, José R.

; Silva, Adelino S. R. da

Motriz: Revista de Educação Física

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2017, Volume 23 N. spe elocation e101611

Abstract: En | Text: En | PDF: En

Abstract AIMS Previously, we verified that overtrained mice upregulated the TRB3 levels, its association with Akt, and the hepatic concentrations of glycogen. It is known that APPL1 can limit the interaction between TRB3 and Akt, playing an important role in the glucose homeostasis. Thus, we verified the effects of three overtraining protocols on the hepatic levels of APPL1 and APPL2. METHODS Rodents were divided into control (CT), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up) and overtrained by running without inclination (OTR). The hepatic contents of APPL1 and APPl2 were measured by the immunoblotting technique. RESULTS Significant elevation of APPL1 observed in the OTR/down and OTR/up groups, as well as the tendency of increase (p=0.071) observed in the OTR group. CONCLUSION These results indicate that this particular protein is likely to participate in the glucose homeostasis previously observed in response to these OT protocols.

https://doi.org/10.1590/s1980-6574201700si0014 890 downloads

Hypothalamic endoplasmic reticulum stress of overtrained mice after recovery
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Pinto, Ana P.

; Oliveira, Luciana da C.

; Rocha, Alisson L. da

; Pereira, Bruno C.

; Morais, Gustavo P.

; Vicente, Larissa Gaioto de

; Moura, Leandro P.

; Pauli, José R.

; Silva, Adelino S. R. da

Motriz: Revista de Educação Física

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2017, Volume 23 N. spe elocation e101605

Abstract: En | Text: En | PDF: En

Abstract AIMS knowing the relationship between endoplasmic reticulum (ER) stress and inflammation and based on the fact that downhill running-based overtraining (OT) model increases hypothalamus levels of some pro-inflammatory cytokines, we verified the effects of three OT protocols on the levels of BiP, pIRE-1 (Ser734), pPERK (Thr981), pelF2alpha (Ser52), ATF-6 and GRP-94 proteins in the mouse hypothalamus after two weeks of recovery. METHODS the mice were randomized into control (CT), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up) and overtrained by running without inclination (OTR) groups. After 2-week total recovery period (i.e., week 10), hypothalamus was removed and used for immunoblotting. RESULTS the OTR/down group exhibited high levels of BiP and ATF6. The other OT protocols showed higher levels of pPERK (Th981) and pelf-2alpha (Ser52) when compared with the CT group. CONCLUSION the current results suggest that after a 2-week total recovery period, the overtrained groups increased partially their ER stress protein levels, but without hypothalamic inflammation, which characterizes a physiological condition related to an adaptation mechanism.

https://doi.org/10.1590/s1980-6574201700si0012 938 downloads

Lesões podais em ovinos da Mesorregião Sudoeste do Rio Grande do Sul
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Silveira, Caroline S.

; Damboriarena, Pedro A.

; Morais, Raissa M.

; Trost, Maria Elisa

; Pozzobon, Ricardo

; Anjos, Bruno L.

Pesquisa Veterinária Brasileira

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oct 2016, Volume 36 N. 10 Pages 971 - 978

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Lesões podais em ovinos são causas importantes de perdas econômicas por quedas na produtividade, na reprodução, por gastos com tratamentos ineficientes e com o descarte de animais afetados. Dessa forma, os objetivos foram descrever as principais características das lesões podais observadas em ovinos da Mesorregião Sudoeste do Rio Grande do Sul, seus aspectos epidemiológicos e a importância da ocorrência desses distúrbios para a criação de ovinos nessa região. Foram coletados dados epidemiológicos e clinicopatológicos de rebanhos ovinos da região entre abril de 2014 e abril de 2015 através de visitas técnicas em propriedades rurais. Foram avaliados rebanhos ovinos em 27 propriedades rurais localizadas em diferentes municípios, dos quais 21 registraram a ocorrência de lesões podais com relato de perdas econômicas significativas. Aproximadamente 1.700 ovinos, em média 10% dos rebanhos, apresentavam diferentes graus de claudicação decorrente de lesões podais que variavam de brandas a severas. Verificou-se que diversos fatores como clima e manejo foram favoráveis para o desenvolvimento das lesões podais e essas podem estar associadas a diferentes distúrbios e agentes etiológicos. No entanto, embora essas condições sejam importantes, o controle e a prevenção tem se mostrado ineficientes. Observou-se ainda que a pododermatite infecciosa dos ovinos (Footrot), parece ser a principal doença podal na região e atualmente pode ser considerada uma doença negligenciada.

ABSTRACT: Foot lesions in sheep are important causes of economic loss due to fall in productivity, reproduction, by spending on ineffective treatment and elimination of affected animals. The purpose of this study was described the main features of foot lesions of sheep from southwestern Rio Grande do Sul, as well as epidemiological aspects and the importance of occurrence of these lesions for sheep farming in the region. Epidemiological and clinic-pathological information of sheep herds from the region between April 2014 and April 2015, by means of visits to farms. In the study were evaluated 27 sheep flocks on farms located in different municipalities. In 21 farms was reported occurrence of foot lesions in sheep having caused significant economic losses. About 1700 sheep, 10% of herds, showed different degree of lameness caused by foot lesions ranging from mild to severe. It was found that several factors, such as climate and breeding were favorable for the development of foot injuries which may be associated with different disorders and etiologic agents. Although these injuries are important, the control and prevention has proved ineffective. Also was observed that infectious pododermatitis (Footrot) may be the main foot disease of sheep in the region, and can be considered a neglected disease.

https://doi.org/10.1590/s0100-736x2016001000009 4046 downloads

Natural Sarcocystis gigantea infection in sheep from Southern Brazil
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Damboriarena, Pedro Araujo

; Silveira, Caroline Silva

; Morais, Raissa Moreira

; Anjos, Bruno Leite

Ciência Rural

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jul 2016, Volume 46 N. 7 Pages 1229 - 1232

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Doenças causadas por protozoários do gênero Sarcocystispodem causar sérios prejuízos em rebanhos de ovinos, por induzirem retardo no crescimento e condenação parcial ou total das carcaças em abatedouro. O presente trabalho descreve a infecção natural por Sarcocystis giganteaem ovinos abatidos em uma propriedade rural no Rio grande do Sul. Entre julho e setembro de 2013, três ovinos apresentaram múltiplos nódulos no esôfago, os quais, microscopicamente, corresponderam a cistos circundados por cápsula rugosa, repletos de estruturas alongadas, basofílicas e nucleadas, morfologicamente compatíveis com bradizoítos de S. gigantea.Os dados epidemiológicos unidos aos achados macroscópicos e microscópicos permitiram o diagnóstico conclusivo. Esse foi o primeiro relato dessa infecção no Rio Grande Sul e deve ser reconhecida por veterinários de campo e especialmente no momento da inspeção das carcaças no abatedouro.

ABSTRACT: Protozoal diseases caused by species of Sarcocystiscan cause serious damage in sheep flocks, inducing decreased growth conversion rates and partial or complete loss of carcasses at the slaughterhouse. This article describes an outbreak of Sarcocystis giganteainfection in sheep slaughtered in a farm in Rio Grande do Sul State, Brazil. Between July and September 2013, three sheep showed multiple nodules in the esophagus that were microscopically characterized as encapsulated cysts filled with elongated, basophilic, nucleated structures morphologically consistent with S. giganteabradyzoites. Diagnosis was made based on the epidemiological, macroscopic, and microscopic findings. This is the first report of this infection in sheep in Rio Grande do Sul and should be recognized by veterinarians, especially during meat inspection.

https://doi.org/10.1590/0103-8478cr20151183 3021 downloads

Influence of preoperative propranolol on cardiac index during the anhepatic phase of liver transplantation
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Seiberlich, Emerson

; Sanches, Marcelo D.

; Morais, Bruno S.

; Maciel, Jader F.

Revista Brasileira de Anestesiologia

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jun 2015, Volume 65 N. 3 Pages 170 - 176

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

INTRODUÇÃO: O transplante hepático (TH) é a melhor opção terapêutica para doença hepática em estágio terminal (DHET). As medicações betabloqueadoras não seletivas, como o propranolol, atuam diretamente no sistema cardiovascular (SCV) e são frequentemente usadas na prevenção de hemorragia digestiva decorrente da HP. Os efeitos do propranolol no SCV de cirróticos durante o TH não são conhecidos. OBJETIVO: Avaliar a influência do uso pré-operatório do propranolol no índice cardíaco (IC) durante a fase anepática do TH. MÉTODO: Avaliaram-se 101 pacientes adultos (73 homens, 72,2%) submetidos a transplante ortotópico de fígado doador cadáver, pela técnica de piggyback com preservação da veia cava inferior retro-hepática, feito no Hospital das Clínicas da Universidade Federal de Minas Gerais. Não houve diferença de gravidade pelo sistema MELD entre os grupos, p = 0,70. Foram comparados o uso pré-operatório de propranolol com o desfecho do IC durante a fase anepática do TH em cinco grupos (I: aumento do IC; II: redução do IC inferior a 16%; III: redução do IC igual a ou maior do que 16% e menor do que 31%; IV: redução do IC igual a ou maior do que 31% e menor do que 46%;V: redução do IC igual a ou maior do que 46%). RESULTADOS: Pacientes que fizeram uso pré-operatório de propranolol no grupo I (46,4%) foram estatisticamente semelhantes aos dos grupos II (60%), III (72,7%), IV (50%) e V (30,8%), p = 0,57. CONCLUSÃO: O propranolol no pré-transplante, como profilaxia para hemorragia digestiva, pode ser considerado seguro, pois não se associou à pioria do IC na fase anepática do TH.

INTRODUCTION: Liver transplantation is the best therapeutic option for end-stage liver disease. Non-selective beta-blocker medications such as propranolol act directly on the cardiovascular system and are often used in the prevention of gastrointestinal bleeding resulting from HP. The effects of propranolol on cardiovascular system of cirrhotic patients during liver transplantation are not known. OBJECTIVE: Evaluate the influence of propranolol used preoperatively on cardiac index during the anhepatic phase of liver transplantation. METHOD: 101 adult patients (73 male [72.2%]) who underwent cadaveric donor orthotopic liver transplantation by piggyback technique with preservation of the retrohepatic inferior vena cava performed at Hospital das Clinicas, Federal University of Minas Gerais were evaluated. There was no difference in severity between groups by the MELD system, p = 0.70. The preoperative use of propranolol and the cardiac index outcome were compared during the anhepatic phase of liver transplantation in 5 groups (I: increased cardiac index, II: cardiac index reduction lower than 16%, III: cardiac index reduction equal to or greater than 16% and less than 31%, IV: cardiac index reduction equal to or greater than 31% and less than 46%, V: cardiac index reduction equal to or greater than 46%). RESULTS: Patients in group I (46.4%) who received propranolol preoperatively were statistically similar to groups II (60%), III (72.7%), IV (50%) and V (30.8%), p = 0.57. CONCLUSION: The use of propranolol before transplantation as prophylaxis for gastrointestinal bleeding may be considered safe, as it was not associated with worsening of cardiac index in anhepatic phase of liver transplantation.

INTRODUCCIÓN: El trasplante hepático (TH) es la mejor opción terapéutica para la enfermedad hepática en estado terminal. Los betabloqueantes no selectivos, como el propranolol, actúan directamente en el sistema cardiovascular y a menudo son usadas en la prevención de la hemorragia digestiva proveniente de la hipertensión portal. Los efectos del propranolol en el sistema cardiovascular de cirróticos durante el TH no se conocen. OBJETIVO: Evaluar la influencia del uso preoperatorio del propranolol en el índice cardíaco (IC) durante la fase anhepática del TH. MÉTODO: Se estudiaron 101 pacientes adultos (73 hombres [72,2%]) sometidos a trasplante ortotópico de hígado de donante cadáver, por la técnica de piggyback con preservación de la vena cava inferior retrohepática, en el Hospital das Clínicas de la Universidad Federal de Minas Gerais. No hubo diferencia respecto a la gravedad por el sistema Meld entre los grupos (p = 0,70). Se comparó el uso preoperatorio del propranolol con el resultado del IC durante la fase anhepática del TH en 5 grupos (i: aumento del IC; ii: reducción del IC < 16%; iii: reducción del IC ≥ 16% y < 31%; iv: reducción del IC ≥ 31% y < 46%;v: reducción del IC ≥ 46%). RESULTADOS: El número de pacientes que usaron el propranolol en el preoperatorio en el grupo i (46,4%) fue estadísticamente similar a los grupos ii (60%), iii (72,7%), iv (50%) y v (30,8%), p = 0,57. CONCLUSIÓN: El propranolol en el pretrasplante, como profilaxis para la hemorragia digestiva, puede ser considerado seguro porque no se asoció con el empeoramiento del IC en la fase anhepática del TH.

https://doi.org/10.1016/j.bjane.2014.02.017 2892 downloads

10.

Adubação nitrogenada e idade de corte na produção de matéria seca do capim-elefante no Cerrado
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Flores, Rilner A.

; Urquiaga, Segundo S.

; Alves, Bruno J. R.

; Collier, Leonardo S.

; Morais, Rafael F. de

; Prado, Renato de M.

Revista Brasileira de Engenharia Agrícola e Ambiental

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dec 2012, Volume 16 N. 12 Pages 1282 - 1288

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Propôs-se, com este trabalho, avaliar o efeito da aplicação de N e da idade de corte na produção de biomassa e acúmulo de nitrogênio pelo capim-elefante. O experimento foi realizado com o capim-elefante cv. Paraíso, cultivado em um Latossolo Vermelho-Amarelo distrófico, município de Gurupi, TO, safra 2008/2009. Foram testadas quatro doses de N-uréia (0, 50, 100 e 150 kg ha-1) e três idades de corte do capim (120, 150 e 180 dias após o brotamento). Avaliou-se, em cada idade de corte, a produção de matéria seca da parte aérea (folhas e colmos) e o acúmulo de N na planta. A produção de matéria seca do capim-elefante aumentou com a adição de N porém o efeito foi maior para as plantas cortadas com 180 dias de idade. Encontrou-se um incremento linear na acumulação de matéria seca (R² = 0,75**) e na acumulação de N (R² = 0,96**), permitindo uma produtividade de 34 t ha-1 de matéria seca, que implicou em uma extração de N de 471 kg ha-1. A eficiência de utilização do N pela cultura variou com o aumento da idade da planta, o que significou maior quantidade de biomassa por unidade de N absorvido. O índice de eficiência mostra que o corte tardio pode favorecer a qualidade da biomassa para fins energéticos, por se tratar de um material mais fibroso.

The objective of this study was to investigate the effect of the application of N fertilizer and the cutting age on the dry biomass production of elephant grass. The experiment was performed with the variety Paraíso and planted in a Ferralsol in 2008 in the district of Gurupi (State of Tocantins). Four different rates of urea application were tested (0, 50, 100 and 150 kg ha-1) and harvests were made at 120, 150 or 180 days after germination (DAG) of the setts. The dry matter and total N accumulation were evaluated. Dry matter production increased with dose of N, the greatest effect being observed at 180 DAG. There was a linear increase in dry matter (R² = 0.75**) and N accumulation (R² = 0.96**) permitting a productivity of 34 t ha-1 of dry matter and an accumulation of 471 kg N ha-1. The N utilization efficiency (biomass production per unit of applied N) increased with plant age. The higher efficiency of N use favored the quality of biomass production for energy production owing to the higher fibre content.

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11.

Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites
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Kossuga, Miriam H.

; Romminger, Stelamar

; Xavier, Camila

; Milanetto, Marília C.

; Valle, Milene Z. do

; Pimenta, Eli F.

; Morais, Raquel P.

; Carvalho, Erica de

; Mizuno, Carolina M.

; Coradello, Luís Fernando C.

; Barroso, Vinícius de M.

; Vacondio, Bruna

; Javaroti, Darci C. D.

; Seleghim, Mirna H. R.

; Cavalcanti, Bruno C.

; Pessoa, Claudia

; Moraes, Manoel O.

; Lima, Bruna A.

; Gonçalves, Reginaldo

; Bonugli-Santos, Rafaella C.

; Sette, Lara D.

; Berlinck, Roberto G. S.

Revista Brasileira de Farmacognosia

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apr 2012, Volume 22 N. 2 Pages 257 - 267

Abstract: En | Text: En | PDF: En

In the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains isolation and growth, and yielded the largest number of strains from marine macroorganisms. The percentage of strains isolated using each of the growth media which yielded cytotoxic and/or antibiotic extracts was in the range of 23-35%, regardless of the growth media used. Further investigation of extracts obtained from different marine-derived fungal strains yielded several bioactive secondary metabolites, among which (E)-4-methoxy-5-(3-methoxybut-1-enyl)-6-methyl-2H-pyran-2-one is a new metabolite isolated from the Penicillium paxilli strain Ma(G)K.

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12.

Corpo estranho no cone orbitário: relato de caso
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Leal Filho, Manoel Baldoino

; Almeida, Bruno Ribeiro de

; Aguiar, Aline de Almeida Xavier

; Vieira, Marcelo Adriano C. S.

; Morais, Ricardo Keyson P. de

; Dantas, Karoline da Silva

Arquivos de Neuro-Psiquiatria

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jun 2003, Volume 61 N. 2B Pages 490 - 493

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Traumatismos orbitários podem estar associados à presença de corpos estranhos, cuja retenção leva a prejuízos, como perda da visão ou abscesso cerebral. Apresentamos o caso de um homem de 21 anos, que evoluiu com ptose palpebral, limitação dos movimentos oculares e reação inflamatória no olho direito, após colisão com um galho de árvore. A TC de órbitas evidenciou uma área de densidade aumentada no cone orbitário direito. Após a retirada neurocirúrgica do corpo estranho, um fragmento de madeira medindo 2,0x0,3 cm, o paciente evoluiu bem, sem déficit visual, com regressão da ptose e resolução do processo inflamatório. A TC de controle pós-operatório não identificou fragmentos do corpo estranho. O caso chama a atenção pelo fato de o fragmento de madeira ter sido visualizado no estudo tomográfico com densidade elevada (136 UH) 2 meses após o acidente e pela aplicação da craniotomia supra-orbitária para a sua retirada.

Orbital injuries may be associated with the presence of foreign bodies in which long retention leads to damages such as loss of vision or cerebral abscess. We present the case of a 21-year-old male patient that developed ptosis, limitation of movements and an inflammatory reaction in the right eye after being hit by a tree branch. A CT scan of the orbits revealed an increased density in the right orbital cone. After the neurosurgical approach for the removal of the foreign body, a wooden fragment measuring 2.0x0.3 cm, the patient had a good outcome without visual deficits, ptosis regression and resolution of the inflammatory process. The postoperative CT scan didn't identify any remaining foreign body fragment. This case calls attention to the fact that the wooden splinter presented on CT scan with high density (136 HU) two months after the trauma and was removed by a supraorbital craniotomy.

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