Resumen Los avances tecnológicos y el contexto de pandemia han posicionado a la mediación virtual como una potente alternativa para el tránsito y proyección de las instituciones de educación superior y su adaptabilidad a las nuevas demandas, contextos y cambios. La implementación de la mediación virtual a distancia como consecuencia de la pandemia por Covid-19 ha impactado en el sentido de pertenencia y el compromiso estudiantil en la educación superior con modalidad presencial; sin embargo, surge la pregunta de cómo se consolida el comportamiento de estas variables en instituciones de educación superior en las cuales la mediación virtual a distancia siempre ha sido su sello metodológico. Con el objetivo de establecer el perfil del estudiantado de la Universidad Nacional Abierta y a Distancia (UNAD) en estos contextos y el análisis e interacción de las variables de compromiso estudiantil y sentido de pertenencia, en este orden de ideas y de manera aleatoria, se toma una muestra de 312 estudiantes de la universidad anteriormente mencionada. Este estudio se desarrolla desde un paradigma positivista, con un nivel de profundización descriptivo-inferencial, con registro prospectivo, transversal y no experimental. Se hizo uso de 2 instrumentos para la recolección de información, el primero centrado en la medición del grado y la orientación del compromiso estudiantil y el segundo identifica factores determinantes en el sentido de pertenencia. Finalmente, se concluye que existe una diferencia tangible entre el perfil del estudiante de educación a distancia al ponerlo en comparación con el estudiante de educación presencial; por otra parte, se recomienda ahondar en investigaciones centradas en los procesos de sentido de pertenencia y de compromiso estudiantil, más aún en la Educación Superior a distancia, la cual no ha sido lo suficientemente explorada.

Abstract Both technological advances and the context of the pandemic have positioned virtual mediation as a strong alternative for the transit and projection of higher education institutions and their adaptability to new demands, contexts, and changes. The implementation of remote virtual mediation as a consequence of the Covid-19 pandemic has impacted the sense of belonging and student commitment in higher education with face-to-face modality. However, the question arises as to how the behavior of these variables is consolidated in higher education institutions in which remote virtual mediation has always been their methodological hallmark. Seeking to establish the profile of the students of the National Open and Distance University (UNAD) in these contexts and to analyze the interaction of the variables of student commitment and sense of belonging, in this order of ideas and in a random manner, the investigators took a sample of 312 students from the aforementioned university. In this way, the study was developed from a positivist paradigm, with a descriptive-inferential level of depth, with a prospective, cross-sectional and non-experimental record. In addition, the authors used 2 instruments for data collection. The first one was focused on the measurement of the degree and the orientation of the student commitment, while the second one identified determinant factors in the sense of belonging. Finally, the investigators concluded that there is a tangible difference between the profile of the distance education student and that of face-to-face education. Likewise, it is recommended to delve into research focused on the processes of a sense of belonging and student commitment, even more so in distance Higher Education, which has not been sufficiently explored.

ABSTRACT Objectives: To determine the frequency of depression and anxiety among Latin American medical students during social distancing in the COVID-19 outbreak period. Methods: Observational, descriptive and cross-sectional design, the study included all Latin American medical students affiliated to the Federación Latinoamericana de Sociedades Científicas de Estudiantes de Medicina (FELSOCEM) selected through non-probabilistic convenience sampling who agreed to participate in the study. Data was collected through a questionnaire, consisting primarily of socio-demographic characteristics such as age, gender, marital status, and country of origin; as a second section, the Goldberg depression and anxiety test was applied, and an analysis was carried out by the nature of the variables. The research protocol was approved by an institutional ethics committee. Results: Of 1579 participating students, from 15 Latin American countries, 68.59% (1083) were women, 65.04% (1027) were between 20 and 24 years old, 95.63% (1510) were single, 23.18% (366) lived in Panama and 11.08% (175) in Chile. 87.14% (1376) have symptoms of anxiety, 66.88% (1056) have symptoms of depression and 64.34% (1016) have both symptoms. Conclusions: A high percentage of medical students in Latin American population suffered symptoms of anxiety and depression during the social distancing measures in the covid-19 outbreak period, data that must be taken into account for future mental health strategies.

RESUMEN Objetivos: Determinar la frecuencia de depresión y ansiedad en estudiantes de la carrera de medicina de Latinoamérica durante el distanciamiento social en el período de brote del COVID-19. Métodos: Diseño observacional, descriptivo y corte transversal, se incluyó en el estudio todos los estudiantes de medicina de Latinoamérica que se encuentren afiliados a la Federación Latinoamericana de Sociedades Científicas de Estudiantes de Medicina (FELSOCEM) seleccionados a través del muestreo no probabilístico por conveniencia que accedieron participar del estudio. Mediante un cuestionario se recopilaron datos, compuesto primeramente por características sociodemográficas como edad, género, estado civil y país de procedencia; como segunda sección, el instrumento estuvo compuesto por el test de depresión y ansiedad de Goldberg, se realizó un análisis en concordancia con la naturaleza de las variables. El protocolo de investigación fue aprobado por un comité de ética institucional. Resultados: De 1579 estudiantes participantes, de 15 países latinoamericanos, 68.59% (1083) fueron mujeres, 65.04% (1027) tenían entre 20 y 24 años, 95.63% (1510) eran solteros, 23.18% (366) vivían en Panamá y 11.08% (175) en Chile. El 87.14% (1,376) tienen síntomas de ansiedad, el 66.88% (1,056) tienen síntomas de depresión y el 64.34% (1,016) tienen ambos síntomas. Conclusiones: Un alto porcentaje de la población médico-estudiantil latinoamericana padecieron de síntomas de ansiedad y depresión durante las medidas de distanciamiento social en el periodo de brote del covid-19, dato que tiene que ser tomado en cuenta para futuras estrategias sobre salud mental.

Resumen Introducción: Aunque COVID-19 (enfermedad por coronavirus 2019) en niños es usualmente leve, en casos excepcionales requieren hospitalización y cuidados intensivos. Los resultados adversos han sido observados principalmente en los niños con comorbilidades, justificando su vacunación. El objetivo de este estudio fue evaluar el riesgo de hospitalización y muerte en niños y adolescentes mexicanos con COVID-19 y comorbilidades. Métodos: Estudio transversal en 366,542 casos de COVID-19 confirmados, menores de 18 años y reportados por la Secretaría de Salud de México, hasta el 9 de julio del 2022. Se ejecutaron modelos multivariados de regresión logística. Resultados: El promedio de edad fue de 10.98 años, 50.6% de sexo masculino, y 7.3% reportaron al menos una comorbilidad. El porcentaje de hospitalización y muerte en pacientes con COVID-19 sin comorbilidades fue 3.52% y 0.20%, respectivamente; mientras que los pacientes con comorbilidades presentaron más elevados porcentajes de hospitalización (14.0%) y muerte (1.9%). La probabilidad de hospitalización fue 5.6 veces más en los pacientes con COVID-19 y comorbilidades, comparando con aquellos sin comorbilidades. Las comorbilidades que mostraron más riesgo fueron inmunosupresión (razón de momios (RM) 22.06), enfermedad renal crónica (ERC) (RM 11.36) y enfermedades cardiovasculares (RM 5.66). La probabilidad de muerte en los pacientes con comorbilidades fue 11.01 veces más que en aquellos sin enfermedades, y fue más elevado en aquellos con ERC (RM 12.57), enfermedades cardiovasculares (RM 6.87) y diabetes (RM 5.83). Conclusiones: Los pacientes pediátricos con comorbilidades presentaron mayor riesgo de COVID-19 severo, por lo que se sugiere promover con mayor énfasis la vacunación en ellos.

Abstract Background: Although COVID-19 (coronavirus disease 2019) in children is usually mild, they need hospitalization and intensive care in exceptional cases. Adverse outcomes have been observed mainly among children with comorbidities, justifying their vaccination. This study aimed to assess the risk of hospitalization and death in Mexican children and adolescents with COVID-19 and comorbidities. Methods: A cross-sectional study was performed on 366,542 confirmed COVID-19 cases under 18 years, reported by the Mexican Ministry of Health up to July 9, 2022. Logistic regression models were performed. Results: The mean age was 10.98 years, 50.6% were male, and 7.3% reported at least one comorbidity. The percentage of hospitalization and death in COVID-19 patients with and without comorbidities was 3.52%, and 0.20%, respectively; children with comorbidities presented a higher percentage of hospitalization (14.0%) and death (1.9%). The probability of hospitalization was 5.6 times greater in pediatric patients with COVID-19 and comorbidities, and the comorbidities that showed the greatest risk were immunosuppression (odds ratio (OR) 22.06), chronic kidney disease (CKD) (11.36), and cardiovascular diseases (5.66). The probability of death in patients with comorbidities was 11.01 times higher than in those without diseases, and the highest risk was observed in those with CKD (OR 12.57), cardiovascular diseases (6.87), and diabetes (5.83). Conclusions: Pediatric patients with comorbidities presented a higher risk of severe COVID-19. It is suggested that vaccination should be promoted with greater emphasis on pediatric patients with comorbidities.

RESUMO OBJETIVO Descrever as tendências na produção de próteses odontológicas pelo Sistema Único de Saúde (SUS) em idosos de 60 anos ou mais no Brasil e nas regiões do país de 2010 a 2019, e o impacto da pandemia de covid-19 na produção esperada para 2020 e 2021. MÉTODOS Estudo de séries temporais que utilizou dados secundários provenientes do banco de dados do SUS (Datasus–Tabnet), e do Instituto Brasileiro de Geografia e Estatística, no período de 2010 a 2021. Calcularam-se as taxas padronizadas por idade para o Brasil e regiões de cada ano analisado. Regressões lineares generalizadas, pelo método de estimação de Prais-Winstein, estimaram as tendências das produções. RESULTADOS Houve tendência de crescimento na taxa padronizada de produção das próteses totais e das demais próteses para cada 100 mil habitantes, no Brasil e em todas as regiões do país. O aumento na produção de próteses totais foi maior na região Nordeste (50,3%/ano) e menor na região Norte (19,1%/ano). As tendências na produção das demais próteses foram maiores na região Sudeste (120,7%/ano) e menores na região Norte (24,5%/ano). A produção de próteses para ambos os grupos diminuiu nos anos de pandemia. Em 2020, a diferença relativa variou de -36,4% (Norte) até -61,7% (Nordeste) para a produção de próteses totais e de -17,9% (Norte) até -68,4% (Nordeste) para as demais próteses. Em 2021, as taxas padronizadas e a produção absoluta aumentaram quando comparadas ao ano anterior, todavia, em relação aos valores esperados, as diferenças foram próximas às encontradas em 2020. CONCLUSÃO Políticas voltadas para a produção de próteses totais e das demais próteses vêm tomando forças e crescendo. Todavia, a produção se mantém distante da necessidade da população e não há equidade na oferta dos serviços. A pandemia de covid-19 impactou negativamente na produção de próteses dentárias pelo SUS.

ABSTRACT OBJECTIVE Describe the trends in the production of dental prosthetics by the Unified Health System (SUS) in older people aged 60 years or older in Brazil and country regions from 2010 to 2019 and the impact of the covid-19 pandemic on the expected production for 2020 and 2021. METHODS A time series study using secondary data from the SUS database (Datasus-Tabnet) and the Instituto Brasileiro de Geografia e Estatística (Brazilian Institute of Geography and Statistics - IBGE) from 2010 to 2021. Age-standardized rates were calculated for Brazil and regions for each year analyzed. Generalized linear regressions estimated production trends using the Prais-Winstein estimation method. RESULTS A growth trend occurred in the standardized production rate of complete dentures and other prosthetics per 100,000 inhabitants in Brazil and all country regions. The increase in the production of complete dentures was higher in the Northeast region (50.3%/year) and lower in the North region (19.1%/year). Trends in the production of other prosthetics were higher in the Southeast region (120.7%/year) and lower in the North region (24.5%/year). The output of prosthetics for both groups decreased in the pandemic years. In 2020, the relative difference ranged from -36.4% (North) to -61.7% (Northeast) for producing complete dentures and from -17.9% (North) to -68.4% (Northeast) for other prosthetics. In 2021, standardized rates and total production increased compared to the previous year. However, compared with expected values, the differences were close to those in 2020. CONCLUSION Policies aimed at producing complete dentures and other prosthetics have been increasing. However, production remains far from the population’s needs, and there is no equity in providing services. The covid-19 pandemic negatively impacted the production of dental prosthetics by SUS.

Abstract Introduction Vancomycin is widely prescribed to treat or prevent Gram-positive infections in pediatric liver transplant recipients. The objective of this prospective cohort study is to describe vancomycin pharmacokinetics and to evaluate the therapeutic target attainment after initial dose regimen. Materials and methods Patients with previous renal injury were excluded. Vancomycin therapy started with 40‒60 mg/kg/day. The pharmacokinetic parameters were assessed using two steady-state blood samples and the first-order kinetic equations. Therapeutic target was defined as vancomycin 24-hour Area Under the Curve/Minimum Inhibitory Concentration (AUC/MIC) ≥ 400 and < 600. Results Sixteen patients were included. The found vancomycin clearance, half-life, and volume of distribution were, respectively: 2.1 (1.3‒2.8) mL/kg/min, 3.3 (2.7‒4.4) hours, and 0.7 (0.5‒0.9) L/kg. With the initial dose, only 6 (37 %) patients reached the therapeutic target against Gram-positive pathogens with MIC 1 mg/L. After individual dose adjustments, all patients reached the target. The correlation between trough levels and AUC was low (R2= 0.5). Conclusions Pediatric patients with preserved renal function after liver transplantation have an increased volume of distribution for vancomycin, and most patients present subtherapeutic levels after the standard initial dosing regimen. With the vancomycin AUC-guided monitoring and dosing, it is possible to improve therapeutic target attainment.

Abstract Objective: To describe the speech pattern of patients with hereditary Spastic Paraplegia type 4 (SPG4) and correlated it with their clinical data. Methods: Cross-sectional study was carried out in two university hospitals in Brazil. Two groups participated in the study: the case group (n = 28) with a confirmed genetic diagnosis for SPG4 and a control group (n = 17) matched for sex and age. The speech assessment of both groups included: speech task recording, acoustic analysis, and auditory-perceptual analysis. In addition, disease severity was assessed with the Spastic Paraplegia Rating Scale (SPRS). Results: In the auditory-perceptual analysis, 53.5% (n = 15) of individuals with SPG4 were dysarthric, with mild to moderate changes in the subsystems of phonation and articulation. On acoustic analysis, SPG4 subjects’ performances were worse in measurements related to breathing (maximum phonation time) and articulation (speech rate, articulation rate). The articulation variables (speech rate, articulation rate) are related to the age of onset of the first motor symptom. Conclusion: Dysarthria in SPG4 is frequent and mild, and it did not evolve in conjunction with more advanced motor diseases. This data suggest that diagnosed patients should be screened and referred for speech therapy evaluation and those pathophysiological mechanisms of speech involvement may differ from the length-dependent degeneration of the corticospinal tract.

Abstract This study aimed to analyze the molecular characteristics of oral epithelial dysplasia (OED), highlighting the pathways and variants of genes that are frequently mutated in oral squamous cell carcinoma (OSCC) and other cancers. Ten archival OED cases were retrieved for retrospective clinicopathological analysis and exome sequencing. Comparative genomic analysis was performed between high-grade dysplasia (HGD) and low-grade dysplasia (LGD), focusing on 57 well-known cancer genes, of which 10 were previously described as the most mutated in OSCC. HGD cases had significantly more variants; however, a similar mutational landscape to OSCC was observed in both groups. CASP8+FAT1/HRAS, TP53, and miscellaneous molecular signatures were also present. FAT1 is the gene that is most affected by pathogenic variants. Hierarchical divisive clustering showed division between the two groups: “HGD-like cluster” with 4HGD and 2LGD and “LGD-like cluster” with 4 LGD. MLL4 pathogenic variants were exclusively in the “LGD-like cluster”. TP53 was affected in one case of HGD; however, its pathway was usually altered. We describe new insights into the genetic basis of epithelial malignant transformation by genomic analysis, highlighting those associated with FAT1 and TP53. Some LGDs presented a similar mutational landscape to HGD after cluster analysis. Perhaps molecular alterations have not yet been reflected in histomorphology. The relative risk of malignant transformation in this molecular subgroup should be addressed in future studies.

ABSTRACT OBJECTIVE Describe the trends in the production of dental prosthetics by the Unified Health System (SUS) in older people aged 60 years or older in Brazil and country regions from 2010 to 2019 and the impact of the covid-19 pandemic on the expected production for 2020 and 2021. METHODS A time series study using secondary data from the SUS database (Datasus-Tabnet) and the Instituto Brasileiro de Geografia e Estatística (Brazilian Institute of Geography and Statistics - IBGE) from 2010 to 2021. Age-standardized rates were calculated for Brazil and regions for each year analyzed. Generalized linear regressions estimated production trends using the Prais-Winstein estimation method. RESULTS A growth trend occurred in the standardized production rate of complete dentures and other prosthetics per 100,000 inhabitants in Brazil and all country regions. The increase in the production of complete dentures was higher in the Northeast region (50.3%/year) and lower in the North region (19.1%/year). Trends in the production of other prosthetics were higher in the Southeast region (120.7%/year) and lower in the North region (24.5%/year). The output of prosthetics for both groups decreased in the pandemic years. In 2020, the relative difference ranged from -36.4% (North) to -61.7% (Northeast) for producing complete dentures and from -17.9% (North) to -68.4% (Northeast) for other prosthetics. In 2021, standardized rates and total production increased compared to the previous year. However, compared with expected values, the differences were close to those in 2020. CONCLUSION Policies aimed at producing complete dentures and other prosthetics have been increasing. However, production remains far from the population’s needs, and there is no equity in providing services. The covid-19 pandemic negatively impacted the production of dental prosthetics by SUS.

RESUMO OBJETIVO Descrever as tendências na produção de próteses odontológicas pelo Sistema Único de Saúde (SUS) em idosos de 60 anos ou mais no Brasil e nas regiões do país de 2010 a 2019, e o impacto da pandemia de covid-19 na produção esperada para 2020 e 2021. MÉTODOS Estudo de séries temporais que utilizou dados secundários provenientes do banco de dados do SUS (Datasus–Tabnet), e do Instituto Brasileiro de Geografia e Estatística, no período de 2010 a 2021. Calcularam-se as taxas padronizadas por idade para o Brasil e regiões de cada ano analisado. Regressões lineares generalizadas, pelo método de estimação de Prais-Winstein, estimaram as tendências das produções. RESULTADOS Houve tendência de crescimento na taxa padronizada de produção das próteses totais e das demais próteses para cada 100 mil habitantes, no Brasil e em todas as regiões do país. O aumento na produção de próteses totais foi maior na região Nordeste (50,3%/ano) e menor na região Norte (19,1%/ano). As tendências na produção das demais próteses foram maiores na região Sudeste (120,7%/ano) e menores na região Norte (24,5%/ano). A produção de próteses para ambos os grupos diminuiu nos anos de pandemia. Em 2020, a diferença relativa variou de -36,4% (Norte) até -61,7% (Nordeste) para a produção de próteses totais e de -17,9% (Norte) até -68,4% (Nordeste) para as demais próteses. Em 2021, as taxas padronizadas e a produção absoluta aumentaram quando comparadas ao ano anterior, todavia, em relação aos valores esperados, as diferenças foram próximas às encontradas em 2020. CONCLUSÃO Políticas voltadas para a produção de próteses totais e das demais próteses vêm tomando forças e crescendo. Todavia, a produção se mantém distante da necessidade da população e não há equidade na oferta dos serviços. A pandemia de covid-19 impactou negativamente na produção de próteses dentárias pelo SUS.

Resumen Introducción: El vitiligo es incurable, lentamente progresivo, su prevalencia varía de 0.4 a 2.0 %. La calidad de vida relacionada con la salud (CVRS) se refiere al bienestar autopercibido asociado a la presencia de una enfermedad y su tratamiento. Métodos: Estudio transversal en un centro dermatológico. Se incluyeron adultos con vitiligo no segmentario (VNS), en tanto que se excluyeron pacientes con otros trastornos pigmentarios y otros tipos de vitiligo. Se aplicó el cuestionario VitiQoL (0 = sin afectación, 90 = máxima afectación), el Vitiligo Extent Score (VES) y el Vitiligo Area Scoring Index (VASI). Resultados: Participaron 492 pacientes, 63 % mujeres. Se obtuvieron 32.6 puntos de promedio en el VitiQoL (IC 95 % = 30.6-34.5). La autopercepción de gravedad y la CVRS se correlacionaron (r = 0.568, p < 0.001). La edad, el sexo femenino, la menor educación y la mayor gravedad autopercibida se asociaron a peor CVRS. La proporción de personas que reportaron una adicción fue similar en los grupos con peor y mejor CVRS (28 % versus 32 %, p = 0.23). Conclusión: La peor CVRS se explica por la autopercepción de gravedad, preocupación por la progresión de la enfermedad, aspecto de la piel y acciones necesarias para evitar la exposición al sol durante la recreación.

Abstract Introduction: Vitiligo is an incurable, slowly progressive skin condition, the prevalence of which ranges from 0.4 to 2.0%. Health-related quality of life (HRQoL) refers to self-perceived well-being associated with the presence of a disease and its treatment. Methods: Cross-sectional study at a dermatological center. Adults with non-segmental vitiligo (NSV) were included, while patients with other pigmentary disorders and other types of vitiligo were excluded. The VitiQoL questionnaire (0 = no skin involvement, 90 = maximum skin involvement), the Vitiligo Extent Score (VES) and the Vitiligo Area Scoring Index (VASI) were applied. Results: 492 patients did participate; 63% were women. An average score of 32.6 was obtained on VitiQoL (95% CI = 30.6-34.5). Self-perception of severity and HRQoL were correlated (r = 0.568, p < 0.001). Age, the female gender, lower education and higher self-perceived severity were associated with poorer HRQoL. The proportion of subjects who reported an addiction was similar in the worst and best HRQoL groups (28% vs. 32%, p = 0.23). Conclusion: Poorer HRQoL is explained by severity self-perception, concern about disease progression, appearance of the skin and necessary actions to avoid sun exposure during recreation.

ABSTRACT The medical records of all liver transplant patients attended at the Centro Especializado San Vicente Fundación between January 2013 and June 2017 were reviewed in order to determine the frequency of post-transplant metabolic syndrome (MS). We collected sociodemographic data, pathological history, toxicological history, complications, and ATP III criteria in a validated instrument. The statistical analysis was carried out with OpenEpi 3.01; p<0.05 was considered as statistically significant. Of the 102 reviewed medical records, 73 met the inclusion criteria (no MS diagnosis prior to transplant and complete information for the instrument) and were analyzed. Most patients were male (59%), older adults (64%) and married (62%). The frequency of MS after liver transplant was 66%. The association between MS and history of hypertension and diabetes was significant. We confirmed that MS is a frequent complication in liver transplant recipients and that history of hypertension and diabetes are the most frequent associated factors.

RESUMEN Se revisaron las historias clínicas de todos los pacientes con trasplante hepático atendidos en el Centro Especializado San Vicente Fundación entre enero de 2013 y junio de 2017, para determinar la frecuencia de síndrome metabólico (SM) postrasplante. En instrumento validado se registraron datos sociodemográficos, antecedentes patológicos, antecedentes toxicológicos, complicaciones y criterios ATP III. Se utilizó OpenEpi 3,01 para análisis estadístico; se consideró significancia estadística con p<0,05. De 102 historias clínicas revisadas, se analizaron 73 que cumplieron criterios de inclusión (sin diagnóstico de SM pretrasplante y con información completa para el instrumento). La mayoría de los pacientes eran hombres (59%), adultos mayores (64%) y casados (62%). La frecuencia de SM postrasplante fue 66%; hubo asociación significativa entre SM y antecedentes de hipertensión arterial y diabetes. Se confirma que el SM es una complicación frecuente de los trasplantados hepáticos y los antecedentes de hipertensión y diabetes son los factores asociados más frecuentes.

Resumen Objetivo: Reportar los resultados iniciales de la cirugía estereotáctica con CyberKnife® (CK®) para etapas avanzadas de melanoma de cuerpo ciliar y coroides (MCC-C) en pacientes mexicanos. Método: Revisión retrospectiva de expedientes clínicos. Se analizaron los resultados de los pacientes a quienes se trató con CK® (Accuray Inc, Sunnyvale, CA, Estados Unidos). Resultados: Cuatro pacientes con MCC-C fueron tratados bajo este protocolo. La media de edad fue de 53.2 ± 5.3 años (rango: 47-60). La mediana de seguimiento fue de 9.5 ± 3.1 meses (rango: 5-12). El diámetro promedio del tumor fue de 13.49 mm, el grosor promedio fue de 11.74 mm y el volumen tumoral promedio fue de 1251.97 mm3. Los tumores tuvieron una configuración de domo (50%) y de seta (50%), de tamaño mediano a grande. Tres pacientes tuvieron un tumor T3b y uno tuvo un tumor T4d en fase inicial según el American Joint Committee on Cancer (AJCC). Se prescribió una dosis promedio de radiación de 2763 ± 181,3 cGy al 90% de la línea de isodosis. Todos los pacientes lograron el control local del tumor después de una sesión de radiocirugía en la última visita de seguimiento. Un paciente presentó datos de toxicidad aguda (desprendimiento seroso de retina) y fue tratado con éxito. Ninguno de los pacientes precisó enucleación secundaria. Conclusiones: El abordaje multidisciplinario con CK® es una terapia efectiva en el manejo del MCC-C de tamaño mediano a grande. Es necesario mayor tiempo de seguimiento para confirmar estos hallazgos y evaluar la morbilidad a largo plazo.

Abstract Objective: To report the early results of CyberKnife® (CK®) stereotactic radiosurgery in advanced stages of ciliochoroidal (CBCh) melanoma in Mexican patients. Method: A retrospective review of charts was performed to analyze the outcomes of patients who underwent CK® (Accuray Inc, Sunnyvale, CA, USA). Results: Four patients with CBCh melanoma were treated under this protocol. The mean age was 53.2 ± 5.3 years (range: 47-60). Median of follow-up was 9.5 ± 3.1 months (range: 5-12). Mean tumor diameter was 13.49 mm, mean thickness, 11.74 mm, and mean gross tumor volume, 1251.97 mm3. Tumors were dome- (50%) and mushroom-spahed (50%), in medium-to-large sizes. Three patients had T3b tumors, and 1 had a T4d tumor at the early tumor staging according to the American Joint Committee on Cancer (AJCC). A mean dose of 2763 ± 181.3 cGy was prescribed to the 90% isodose line. All patients achieved local tumor control after a single radiosurgical session at the latest follow-up. One patient presented with acute toxicity (extensive serous retinal detachment associated with radiation induced tumor vasculopathy) that was promptly managed. None of the patients required secondary enucleation. Conclusions: CK® appears to be an effective therapy for the management of medium-to-large sized CBCh melanoma. A prospective comparative study with longer follow-up is needed to confirm these findings and assess long-term morbidity.

Resumo: Este artigo apresenta as experiências que vivem os estudantes universitários no contexto do isolamento físico como resultado da pandemia COVID-19. A metodologia utilizada é a pesquisa qualitativa, os participantes foram seis estudantes de La Araucanía, Chile. O instrumento utilizado para coletar a informação é a entrevista semiestruturada. Os resultados mostram situações que geraram ansiedade nos estudantes universitários, o que afetou sua vida pessoal, social e acadêmica, levando a uma reestruturação de sua vida cotidiana. Concluímos que existe a necessidade de um treinamento profissional que forneça estratégias, conhecimentos e habilidades para lidar com problemas de saúde mental.

Abstract: The article exposes experiences by university students in the context of physical isolation due to the COVID-19 pandemic. The methodology used is qualitative research; the participants were six students from La Araucanía, Chile. The information-gathering instrument is the semi-structured interview. The results reveal situations that have generated anxiety in university students, which has affected the personal, social and academic environment, leading to a restructuring of their daily lives. We conclude the need for professional training that provides strategies, knowledge, and skills to face mental health problems.

Resumen: El artículo expone experiencias que viven los estudiantes universitarios en contexto de aislamiento físico producto de la pandemia COVID-19. La metodología utilizada es la investigación cualitativa, los participantes fueron seis estudiantes de La Araucanía, Chile. El instrumento de recolección de información es la entrevista semiestructurada. Los resultados dan cuenta de situaciones que han generado ansiedad en los estudiantes universitarios, lo que ha afectado el ámbito personal, social y académico, llevando a una reestructuración de su vida cotidiana. Concluimos en la necesidad de una formación profesional que aporte con estrategias, conocimientos y habilidades, para enfrentar problemas de salud mental.

Abstract Introduction. The liver continues to be one of the most affected organs in trauma patients. Its evaluation and management have changed substantially with technological advances in diagnosis and less invasive techniques. The objective of this study was to perform an analysis of the results of non-operative management of liver trauma in terms of incidence, efficacy, morbidity and mortality, need for surgical intervention, rate and factors related to the failure of non-operative management. Methods. A retrospective observational descriptive study was performed, analyzing patients with hepatic trauma confirmed by tomography or surgery, during a period of 72 months at the Hospital Universitario San Vicente Fundación level 4 medical center, in Medellín, Colombia. Results. 341 patients with liver trauma were analyzed, 224 with penetrating trauma and 117 with blunt trauma. In the penetrating trauma group, 208 patients were taken to surgery immediately, the rest were managed nonoperatively with a failure in 20 patients. In the blunt trauma group, 22 were taken to immediate surgery and 95 underwent nonoperative management, with failure in nine patients. Overall mortality was 9.7% and mortality related to liver trauma was 4.4%. Trauma grade, trauma severity index, and non-hepatic abdominal injuries were not considered risk factors for failure of nonoperative management Conclusions. Nonoperative management continues to be a safe and effective alternative for patients with liver trauma, especially in blunt trauma. In penetrating trauma, an adequate selection of patients must be made.

Resumen Introducción. El hígado continúa siendo uno de los órganos más afectados en los pacientes con trauma. Su evaluación y manejo han cambiado sustancialmente con los avances tecnológicos en cuanto a diagnóstico y las técnicas de manejo menos invasivas. El objetivo de este estudio fue realizar un análisis de los resultados del manejo no operatorio del trauma hepático en cuanto a incidencia, eficacia, morbimortalidad, necesidad de intervención quirúrgica, tasa y factores relacionados con el fallo del manejo no operatorio. Métodos. Se realizó un estudio descriptivo observacional retrospectivo, analizando pacientes con trauma hepático confirmado con tomografía o cirugía, durante un periodo de 72 meses, en el Hospital Universitario San Vicente Fundación, un centro de IV nivel de atención, en Medellín, Colombia. Resultados. Se incluyeron 341 pacientes con trauma hepático, 224 por trauma penetrante y 117 por trauma cerrado. En trauma penetrante, 208 pacientes fueron llevados a cirugía inmediatamente, el resto fueron manejados de manera no operatoria, con una falla en el manejo en 20 pacientes. En trauma cerrado, 22 fueron llevados a cirugía inmediata y 95 sometidos a manejo no operatorio, con una falla en 9 pacientes. La mortalidad global fue de 9,7 % y la mortalidad relacionada al trauma hepático fue de 4,4 %. El grado del trauma, el índice de severidad del trauma y las lesiones abdominales no hepáticas no se consideraron factores de riesgo para la falla del manejo no operatorio. Conclusiones. El manejo no operatorio continúa siendo una alternativa segura y efectiva para pacientes con trauma hepático, sobretodo en trauma cerrado. En trauma penetrante se debe realizar una adecuada selección de los pacientes.

Abstract Matters of care has been a relevant issue for several decades in feminist studies, particularly in relation to the power relations that have been built from their feminization, and the consequences they have had in all spheres of life. Despite their importance, the way care is spatialized has not been sufficiently treated based on the daily interrelations in which they are part of. Based on research taken place over the course of a decade by a collective group of researchers on the daily mobility practices as well as on care issues, we have been able to identify six categories that contribute to the spatialization of care from a relational spaces approach. Through mobile ethnographies of urban dwellers’ daily lives, we were able to understand how care strategies and circulations take place, and their relation with subjects of care, practices, time spaces, places, affects, materialities and objects that support care in cities like Santiago, Concepción or Temuco. Understanding them from a perspective of relational space helps to visualize the complexity that care implies, and at the same time the intertwined implications of space that go beyond domestic space. This paper contributes to the existing work on the invisible aspects of care including the spatialization of care and to the discussion on the need to defamiliarize and collectivize care in Chile. This is particularly relevant today, as care became a major issue in Chile and globally due to the COVID-19 pandemic, as it was possible to identify the material reality of care in tangible ways, and also to question the ways we want to care for ourselves and our living space in the future.

Resumen Los cuidados han sido un tema clave en los estudios feministas por varias décadas, particularmente en cuanto a las relaciones de poder que se han construido a partir de su feminización y a las consecuencias que han tenido en todas las esferas de la vida. Pese a su importancia, las espacialidades del cuidado no han sido suficientemente profundizadas desde sus interrelaciones cotidianas. A partir de una serie de investigaciones que han puesto el foco en la movilidad cotidiana de las personas y otras específicamente enfocadas al cuidado se han podido identificar categorías relevantes al momento de entender, desde los espacios relacionales evidenciados por la movilidad, las espacialidades del cuidado. Por medio de etnografías móviles, fue posible mostrar aquellas negociaciones, gestiones, objetos y espacios que permiten cuidar en la ciudad. Las categorías resultantes develan seis dimensiones: los sujetos de cuidados, sus prácticas, lugares, materialidades y objetos, temporalidades y afectos que sostienen los cuidados en ciudades como Santiago, Concepción o Temuco. Al entenderlos desde la perspectiva del espacio relacional, es posible visualizar la complejidad que implica cuidar y, al mismo tiempo, la necesidad de espacio que tienen, el que va más allá del espacio doméstico. Esta propuesta contribuye a la importancia de la espacialización de los cuidados al momento de pensar en formas de desfamiliarización y colectivización de los cuidados en general. Esto es particularmente relevante hoy, ya que la pandemia del COVID-19 relevó la realidad material de los cuidados de manera tangible, y nos instó, además, a replantearnos el cómo nos cuidaremos entre humanos y no humanos en el futuro.