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ABSTRACT The objective of this study is to present the protocol of a cluster randomized clinical trial to be conducted through the TeleICU project - Qualification of Intensive Care by Telemedicine. The study will consist of a cluster randomized clinical trial, open label, in pediatric intensive care units, with an allocation ratio of 1:1, to compare the intervention group (support of Telemedicine for patients admitted to the pediatric intensive care unit) with a control group (pediatric intensive care unit usual care). The study proposed to select 16 pediatric intensive care units, including 100 participants per site, with a total of 1,600 participants. The intervention group will receive telerounds from Monday to Friday and will have specialists and continuing education activities available. The primary outcome measure will be the length of stay in the pediatric intensive care unit, defined as the difference between the date of discharge of the participant and the date of admission to the intensive care unit. The secondary outcomes will be mortality rate, invasive mechanical ventilation-free days, days using antibiotics, days using vasoactive drugs and days using sedoanalgesia. This study will be conducted in accordance with Resolution 466/12 of the National Health Council, with approval by the Research Ethics Committee of the institutions involved. The present study has the potential to reproduce studies on Telemedicine in intensive care and may make important contributions to care in intensive care units in Brazil and other settings. If Telemedicine shows positive clinical care results compared to conventional treatment, more pediatric patients may benefit. ClinicalTrials.gov registry: NCT05260710

RESUMO O objetivo deste estudo será apresentar o protocolo de um ensaio clínico randomizado em cluster a ser realizado por meio do projeto TeleUTI - Qualificação da Assistência em Terapia Intensiva por Telemedicina. O estudo consistirá em um ensaio clínico randomizado por cluster, open label, em unidades de terapia intensiva pediátricas, com proporção de alocação de 1:1, com o intuito de comparar o grupo de intervenção (apoio da telemedicina para os pacientes internados na unidade de terapia intensiva pediátrica) com um grupo controle (cuidados habituais da unidade de terapia intensiva pediátrica). O estudo se propõe a selecionar 16 unidades de terapia intensiva pediátricas, incluindo 100 participantes por local, com o total de 1.600 participantes. O grupo intervenção receberá telerounds de segunda-feira a sexta-feira e terá à disposição especialistas e atividades de educação continuada. O desfecho primário a ser avaliado será o tempo de permanência nas unidades de terapia intensiva pediátricas, definido pela diferença entre a data de alta do participante com a data de admissão na unidade de terapia intensiva. Os desfechos secundários serão: taxa de mortalidade; dias livres de ventilação mecânica, dias de uso de antibióticos, dias de uso de drogas vasoativas e dias de uso de sedoanalgesia. Este estudo será conduzido em conformidade com a resolução 466/12 do Conselho Nacional de Saúde, com aprovação pelo Comitê de Ética em Pesquisa das instituições hospitalares envolvidas. O trabalho tem o potencial de reproduzir estudos sobre Telemedicina em cuidados intensivos, podendo trazer contribuições importantes ao atendimento em unidades de terapia intensiva no Brasil e em outras realidades. Se a Telemedicina mostrar resultados clínicos assistenciais positivos em relação ao tratamento convencional, mais pacientes pediátricos poderão ser beneficiados. Registro ClinicalTrials.gov: NCT05260710

https://doi.org/10.5935/2965-2774.20230223-en

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition
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Pinto, Marcus Vinicius

; França Jr, Marcondes Cavalcante

; Gonçalves, Marcus Vinicius Magno

; Machado-Costa, Marcela Câmara

; Freitas, Marcos Raimundo Gomes de

; Gondim, Francisco de Assis Aquino

; Marrone, Carlo Domenico

; Martinez, Alberto Rolim Muro

; Moreira, Carolina Lavigne

; Nascimento, Osvaldo J. M.

; Covaleski, Anna Paula Paranhos

; Oliveira, Acary Souza Bulle de

; Pupe, Camila Castelo Branco

; Rodrigues, Marcia Maria Jardim

; Rotta, Francisco Tellechea

; Scola, Rosana Herminia

; Marques Jr, Wilson

; Waddington-Cruz, Márcia

Arquivos de Neuro-Psiquiatria

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mar 2023, Volume 81 N. 3 Pages 308 - 321

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene. Hereditary transthyretin amyloidosis with peripheral neuropathy is a disabling, progressive and life-threatening genetic condition that leads to death in ~ 10 years if untreated. The prospects for ATTRv-PN have changed in the last decades, as it has become a treatable neuropathy. In addition to liver transplantation, initiated in 1990, there are now at least 3 drugs approved in many countries, including Brazil, and many more are being developed. The first Brazilian consensus on ATTRv-PN was held in the city of Fortaleza, Brazil, in June 2017. Given the new advances in the area over the last 5 years, the Peripheral Neuropathy Scientific Department of the Brazilian Academy of Neurology organized a second edition of the consensus. Each panelist was responsible for reviewing the literature and updating a section of the previous paper. Thereafter, the 18 panelists got together virtually after careful review of the draft, discussed each section of the text, and reached a consensus for the final version of the manuscript.

Resumo Polineuropatia amiloidótica familiar associada a transtirretina (ATTRv-PN) é uma polineuropatia sensitivo-motora e autonômica hereditária autossômica dominante com mais de 130 variantes patogênicas já identificadas no gene TTR. A ATTRv-PN é uma condição genética debilitante, progressiva e que ameaça a vida, levando à morte em ~ 10 anos se não for tratada. Nas últimas décadas, a ATTRv-PN se tornou uma neuropatia tratável. Além do transplante de fígado, iniciado em 1990, temos agora 3 medicamentos modificadores de doença aprovados em muitos países, incluindo o Brasil, e muitas outras medicações estão em desenvolvimento. O primeiro consenso brasileiro em ATTRv-PN foi realizado em Fortaleza em junho de 2017. Devido aos novos avanços nesta área nos últimos 5 anos, o Departamento Científico de Neuropatias Periféricas da Academia Brasileira de Neurologia organizou uma segunda edição do consenso. Cada panelista ficou responsável por rever a literatura e atualizar uma parte do manuscrito. Finalmente, os 18 panelistas se reuniram virtualmente após revisão da primeira versão, discutiram cada parte do artigo e chegaram a um consenso sobre a versão final do manuscrito.

https://doi.org/10.1055/s-0043-1764412

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice
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LIRA, Sandra Machado

; HOLANDA, Marcelo Oliveira

; SILVA, José Ytalo Gomes da

; MARQUES, Chayane Gomes

; COELHO, Lia Corrêa

; LIMA, Carla Laíne Silva

; COSTA, Joana Talita Galdino

; DANTAS, Juliana Barbosa

; MACIEL, Gladstone Lima

; SILVA, Gisele Silvestre da

; SANTOS, Glauber Batista Moreira

; ZOCOLO, Guilherme Julião

; DIONÍSIO, Ana Paula

; GUEDES, Maria Izabel Florindo

Food Science and Technology

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2023, Volume 43 elocation e56822

Abstract: En | Text: En | PDF: En

Abstract Pitaya is a rich source of bioactive compounds, such as polyphenols and betalains. Moreover, these compounds has been associated with reduced risk of type 2 diabetes mellitus. The aim of this study is to evaluate the effect of this fruit on glycemia and oxidative stress in aloxan-induced diabetic mice. Thus, considering that In the in vivo assays, the mice were divided into 5 groups (n = 6): (a) healthy group treated with water; (b) diabetic mice treated with metformin at 200 mg/kg body weight diluted in water; (c) untreated diabetic mice; (d) diabetic mice treated with pitaya at 200 mg/kg and (e) diabetic mice treated with pitaya at 400 mg/kg of body weight diluted in water. The results shows that pitaya was able significantly to reduce blood glucose (p < 0.05) (200 mg/kg); significantly reduce cholesterol (200 and 400 mg/kg) and significantly increase HDL-c (400 mg/kg) levels. In the oxidative stress experiment, Malondialdehyde levels in the liver were significantly reduced (p < 0.05) in the groups treated with pitaya, when compared to the other groups, suggesting lower lipid peroxidation. The consumption of pitaya reduced the blood glucose and cholesterol and increase the HDL, in addition, the lipid peroxidation - which is common in diabetic patients, was reduced.

https://doi.org/10.1590/fst.56822

Acompanhamento de Dois Anos de Pacientes com Cardiopatia Isquêmica Crônica em um Centro Especializado no Brasil
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Moreira, Eduardo Martelli

; Pinesi, Henrique Trombini

; Martins, Eduardo Bello

; Pitta, Fábio Grunspun

; Bolta, Paula Mathias Paulino

; Segre, Carlos Alexandre Wainrober

; Favarato, Desiderio

; Rached, Fabiana Hanna

; Hueb, Whady Armindo

; Lima, Eduardo Gomes

; Kalil Filho, Roberto

; Garzillo, Cibele Larrosa

; Serrano Jr, Carlos Vicente

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 10 elocation e20220440

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background The incidence of cardiovascular events in patients with chronic ischemic heart disease (CIHD) may vary significantly among countries. Although populous, Brazil is often underrepresented in international records. Objectives This study aimed to describe the quality of care and the two-year incidence of cardiovascular events and associated prognostic factors in CIHD patients in a tertiary public health care center in Brazil. Methods Patients with CIHD who reported for clinical evaluation at Instituto do Coração (São Paulo, Brazil) were registered and followed for two years. The primary endpoint was a composite of myocardial infarction (MI), stroke, or death. A significance level of 0.05 was adopted. Results From January 2016 to December 2018, 625 participants were included in the study. Baseline characteristics show that 33.1% were women, median age 66.1 [59.6 – 71.9], 48.6% had diabetes, 83.1% had hypertension, 62.6% had previous MI, and 70.4% went through some revascularization procedure. At a median follow-up (FU) of 881 days, we noted 37 (7.05%) primary endpoints. After adjustments, age, previous stroke, and LDL-cholesterol were independently associated with the primary endpoint. Comparing baseline versus FU, participants experienced relief of angina based on the Canadian Cardiovascular Society (CCS) scale according to the following percentages: 65.7% vs. 81.7% were asymptomatic and 4.2% vs. 2.9% CCS 3 or 4 (p < 0.001). They also experienced better quality of medication prescription: 65.8% vs. 73.6% (p < 0.001). However, there was no improvement in LDL-cholesterol or blood pressure control. Conclusion This study shows that CIHD patients had a two-year incidence of the primary composite endpoint of 7.05%, and the reduction of LDL-cholesterol was the only modifiable risk factor associated with prognosis.

Resumo Fundamento A incidência de eventos cardiovasculares em pacientes com doença cardíaca isquêmica crônica (DCIC) pode variar significativamente entre os países. Embora populoso, o Brasil é frequentemente sub-representado nos registros internacionais. Objetivos Este estudo teve como objetivo descrever a qualidade do atendimento e a incidência de eventos cardiovasculares em dois anos, além de fatores prognósticos associados em pacientes com DCIC em um centro terciário de saúde pública no Brasil. Métodos Pacientes com DCIC que compareceram para avaliação clínica no Instituto do Coração (São Paulo, Brasil) foram cadastrados e acompanhados por dois anos. O desfecho primário foi um composto de infarto do miocárdio (IM), acidente vascular encefálico ou morte. Um nível de significância de 0,05 foi adotado. Resultados De janeiro de 2016 a dezembro de 2018, 625 participantes foram incluídos no estudo. As características basais mostram que 33,1% eram mulheres, a idade mediana era de 66,1 [59,6 – 71,9], 48,6% tinham diabetes, 83,1% tinham hipertensão, 62,6% tinham IM prévio e 70,4% passaram por algum procedimento de revascularização. Em um acompanhamento mediano de 881 dias, 37 (7,05%) desfechos primários foram observados. Após ajustes, idade, acidente vascular encefálico prévio e colesterol LDL foram independentemente associados ao desfecho primário. Comparando a linha de base com o acompanhamento, os participantes relataram alívio da angina com base na escala da Sociedade Cardiovascular Canadense (SCC) de acordo com as seguintes porcentagens: 65,7% vs. 81,7% eram assintomáticos e 4,2% vs. 2,9% eram SCC 3 ou 4 (p < 0,001). Eles também relataram melhor qualidade na prescrição de medicamentos: 65,8% vs. 73,6% (p < 0,001). No entanto, não houve melhora no colesterol LDL ou no controle da pressão arterial. Conclusão O presente estudo mostra que pacientes com DCIC apresentaram uma incidência de 7,05% do desfecho primário composto em um período de dois anos, sendo a diminuição do colesterol LDL o único fator de risco modificável associado ao prognóstico.

https://doi.org/10.36660/abc.20220440

Chemical composition of forage watermelon fruit at different maturity stage or storage length
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Azeredo, Alessandra Bezerra de

; Silva, Ana Paula Ribeiro da

; Matias, Alex Gomes da Silva

; Silva, Valterlina Moreira da

; Correia, Airton Alves Vieira

; Voltolini, Tadeu Vinhas

Acta Scientiarum. Animal Sciences

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2022, Volume 44 elocation e53624

Abstract: En | Text: En | PDF: En

ABSTRACT. This study aimed to assess the chemical responses of forage watermelon fruit at different maturity stages or storage lengths, performing two experimental tests. In the first test, four maturity stages were assessed: 30, 45, 60, and 75 days after anthesis, with four replicates. In the second test, fruits were maintained under three storage lengths: T1D (harvest day), T3M (3 months after harvest), and T6M (6 months after harvest), with eight replicates. Experimental design was completely randomized in both experimental tests. Fruit maturity stage did not affect crude protein, total carbohydrate, neutral detergent fiber, in vitro dry matter digestibility (IVDMD), pulp firmness, soluble solids content and total pectin content, but increased acid detergent fiber content from 45 days after anthesis. Storage length up to six months after harvest increased ash, crude protein and IVDMD, and reduced the content of soluble solids. Forage watermelon fruit can be harvested from 30 to 75 days after anthesis equivalent to 75 - 120 days after planting, and they can be stored under tree shade up to 6 months after harvest.

https://doi.org/10.4025/actascianimsci.v44i1.53624

Associative bacterial diversity of pangolão, a stressresilient tropical grass
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Alves, Michelle Justino Gomes

; Oliveira, Cybelle Souza

; Vitalino, Gisely Moreira

; Carvalho, Eric Xavier de

; Oliveira, José de Paula

; Fracetto, Giselle Gomes Monteiro

; Fracetto, Felipe José Cury

; Lira Junior, Mario Andrade

Bragantia

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2022, Volume 81 elocation e4622

Abstract: En | Text: En | PDF: En

ABSTRACT Some forage species, such as pangolão grass (Digitaria eriantha Steud. cv. Survenola), are resilient in tropical semi arid regions. A possible reason for this is the presence of endophytic and rhizospheric microorganisms. Thus, this study evaluated the diversity of associative bacteria in pangolão grass. Bacteria associated with the roots, culm, leaves, and rhizospheric soil were isolated and characterized in three municipalities of Pernambuco, Brazil. An initial phenotypic characterization was followed by a genotypic assessment by based repetitive extragenic palindromic-polymerase chain reaction (BOX-PCR) and partial sequencing of the 16S rRNA gene. We obtained 325 phenotypically-characterized isolates grouped into 243 strains with 100% similarity by BOX-PCR. The most diverse sampling environment was Araripina, and all factors affected bacterial diversity. There were 135 groups with 90% similarity, that were represented by a single strain each for sequencing. Among the sequenced strains, 118 showed 96.84–99.9% similarity with previously described strains, whereas 17 could not be identified. The following 18 genera were identified from three phyla, five classes, seven orders, and 13 families: Achromobacter, Agrobacterium, Bacillus, Burkholderia, Curtobacterium, Enterobacter, Herbaspirillum, Kosakonia, Ochrobactrum, Paenibacillus, Pantoea, Priestia, Pseudomonas, Rhizobium, Serratia, Shinella, Stenotrophomonas, and Variovorax. The diversity of endophytic and rhizospheric bacteria may contribute to the resilience of pangolão, as various strains of these genera have been described as plant growth promoters. This is the first evaluation of pangolão bacterial diversity under tropical semi arid conditions. Since several of the genera include strains known to promote plant growth, we propose further research to evaluate this on crops.

https://doi.org/10.1590/1678-4499.20220071

HIGHLY SELECTIVE HF-LPME-GC-MS FOR COCAINE AND BIOTRANSFORMATION PRODUCTS IN HUMAN HAIR TO MONITOR DRUG ADDICTS
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Scanferla, Deborah Thais Palma

; Sakurada, Jessica Yuri

; Oliveira, Luís Otávio de

; Lini, Renata Sano

; Aguera, Raul Gomes

; Madia, Mariana Aparecida Oliveira

; Moreira, Paula Pessoa

; Romoli, Jessica Cristina Zoratto

; Bando, Érika

; Machinski Junior, Miguel

; Marchioni, Camila

; Mossini, Simone Aparecida Galerani

Química Nova

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aug 2021, Volume 44 N. 8 Pages 921 - 928

Abstract: En | Text: En | PDF: En

This study aimed to investigate a miniaturized extraction methodology with analysis by GC-MS for simultaneous detection and quantification of cocaine (COC), benzoylecgonine (BZE) and cocaethylene (CE) in hair to monitor drug addicts. The process was done following the international guide of the Scientific Task Force on Forensic Toxicology. After sample extraction, derivatizing solution was added, clean-up was done by the Hollow Fiber Liquid Phase Microextraction (HF-LPME) and adapted to use the ultrasonic bath, a simple and easy-to-handle device. Isobutylchloroformate was first used as derivatization reagent to convert benzoylecgonine to isobutylbenzoylecgonine. Analytes quantification occurred within a linear range of 0.1 to 20 ng mg-1 for COC and 0.05 to 5 ng mg-1 for BZE and CE, with a correlation coefficient of r > 0.99. Limits of detection were 0.05; 0.03 and 0.03 ng mg-1, whereas limits of quantification were 0.1; 0.05 and 0.05 ng mg-1 for COC; BZE and CE, respectively. There was no matrix effect interference. Intra and inter-day precision and accuracy were acceptable according to international guidelines. The analytical method HF-LPME-GC-MS was successfully applied to 14 hair samples from patients admitted in drugs detoxification programs. All samples resulted positive for cocaine (0.80-> 20 ng mg-1) and benzoylecgonine (0.20-> 5 ng mg-1), 11 samples were positive for cocaethylene (0.10-> 0.60 ng mg-1).

https://doi.org/10.21577/0100-4042.20170737 72 downloads

Cardiovascular Risk Factors in Patients with Chronic Kidney Disease Under Conservative Treatment
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Oliveira, Cássia

; Pereira, Priscila Moreira de Lima

; Soares, Iris Teixeira

; Monteiro, Melina Gabriela

; Bastos, Marcus Gomes

; Cândido, Ana Paula Carlos

International Journal of Cardiovascular Sciences

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apr 2021, Volume 34 N. 2 Pages 170 - 178

Abstract: En | Text: En | PDF: En

Abstract Background Cardiovascular disease (CVD) is commonly associated with chronic kidney disease (CKD). These diseases have a significant impact on life expectancy. Individuals with CKD are more likely to die from CVD than to progress to end-stage kidney disease. Objective To assess cardiovascular risk factors of patients with CKD under conservative treatment. Methods This was an observational, cross-sectional study. Socioeconomic, anthropometric, biochemical, and physical inactivity data were assessed, and 10-year risk for CVD were estimated using the Framingham Score in patients with CKD under conservative treatment. For statistical analysis, the Student’s t-test and Pearson’s chi-square test were performed. Results A total of 172 individuals were evaluated, 57% of whom were male, with an average age of 68.85 ± 11.41 years. The prevalence of hypertension and diabetes were 87.2% and 53.5%, respectively; 62.2% were physically inactive; 9.9% of men were smokers and 12.8% consumed alcohol. According to BMI, 82.4% of adults <60 years old and 60.6% of those older than 60 years were overweight. High waist circumference and a high waist-hip ratio were highly prevalent in females (91.9% and 83.8%, respectively) and males (64.3% and 39.8%, respectively); 92.4% had a high body fat percentage and 73.3% high uric acid levels. According to the Framingham score, 57% have a medium or high risk of developing CVD in 10 years. Conclusion There was a high prevalence of cardiovascular risk factors in the population studied. The assessment of cardiovascular risk factors in patients with CKD makes it possible to guide the conduct of health professionals to prevent mortality from cardiovascular causes. Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0

https://doi.org/10.36660/ijcs.20190195 429 downloads

Atividade estrogênica de desreguladores endócrinos em águas superficiais do município de Santa Maria Madalena, Sudeste do Brasil
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Cunha, Danieli Lima da

; Muylaert, Samuel

; Nascimento, Marilia Teresa Lima do

; Silva, Giselle Gomes Moreira da

; Fonseca, Estefan Monteiro da

; Bila, Daniele Maia

; Sarcinelli, Paula de Novaes

; Larentis, Ariane Leites

Engenharia Sanitaria e Ambiental

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feb 2021, Volume 26 N. 1 Pages 21 - 28

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Nas últimas décadas se intensificou o lançamento, no meio hídrico, de contaminantes com capacidade de desregulação endócrina. Nesse contexto, a aplicação e o aprimoramento de métodos analíticos eficientes passam a ser cada vez mais requeridos para verificar os potenciais impactos dessas substâncias sobre os organismos a elas expostos. Bioensaios podem ser conduzidos para esse fim, como, por exemplo, o ensaio in vitro yeast estrogen screen (YES), que permite a detecção de compostos estrogênicos e citotóxicos. Este estudo, aplicando tal ensaio, investigou a atividade estrogênica das águas e seus potenciais riscos à biota aquática de dois corpos hídricos do município de Santa Maria Madalena, no estado do Rio de Janeiro, Sudeste do Brasil. Observou-se atividade estrogênica apenas no córrego São Domingos, com concentrações de equivalente estradiol (EQ-E2) de 23 e 10.4 ng.L−1 no período de estiagem e chuvoso, respectivamente. Os potenciais riscos desse nível de atividade estrogênica foram mensurados por meio de uma avaliação de risco, que revelou alto e médio risco nas estações seca e chuvosa, respectivamente. Cabe mencionar que, entre os corpos hídricos estudados, a área do córrego São Domingos é aquela com maior adensamento populacional e menor cobertura de coleta e tratamento de esgotos. O ensaio YES mostrou ser uma boa ferramenta para a detecção da presença de desreguladores endócrinos estrogênicos, que pode subsidiar o avanço do conhecimento de corpos hídricos e a formulação de legislação e regulamentações da área ambiental.

ABSTRACT In recent decades, the release of contaminants with endocrine disrupting capacity into the water environment has intensified. In this context, the application and improvement of efficient analytical methods are increasingly required to verify the potential impacts of these substances on the organisms exposed to them. Bioassays can be conducted with this purpose, such as the yeast estrogen screen (YES) in vitro assay, which allows the detection of estrogenic and cytotoxic compounds. This study, applying the YES assay, investigated the estrogenic activity and its potential risks to the aquatic biota of two streams in Santa Maria Madalena, Rio de Janeiro State, Southeastern Brazil. Estrogenic activity was observed only in São Domingos stream, with estradiol equivalent (EEQ) concentrations of 23 and 10.4 ng.L−1 during the dry and rainy season, respectively. The potential risks of this level of estrogenic activity were evaluated by a risk assessment, which revealed a high and medium risk to the local biota in the dry and rainy seasons, respectively. Among the studied water bodies, São Domingos watershed has a bigger population density and less sewage collection and treatment comparatively to Ribeirão Santíssimo stream. The YES assay presented itself as a useful tool for spotting estrogenic endocrine disruptors, with the potential to help in expanding knowledge about water bodies and to create and enforce environmental legislation and regulations.

https://doi.org/10.1590/s1413-415220180133 542 downloads

10.

EXPERIMENTOS E PSICOLOGIA SOVIÉTICA: UMA ANTÍTESE METODOLÓGICA EQUIVOCADA
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Moreira, Ana Paula Gomes

; Brockington, Guilherme

; Guzzo, Raquel Souza Lobo

Psicologia Escolar e Educacional

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2021, Volume 25 elocation e228188

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Este trabalho apresenta-se como um ensaio teórico dedicado a enfatizar as bases ontológicas e epistemológicas da Psicologia Soviética para delimitar suas necessárias propriedades metodológicas. Acentuamos o risco anunciado para o campo da Psicologia Histórico-Cultural quando cedemos ao equívoco de esvaziar os sentidos atribuídos por Vigotski e pelos integrantes de seu Círculo ao Método Genético-Experimental à organização metodológica no campo das pesquisas em Psicologia. Por isso, propõe-se como objetivo deste trabalho o resgate da ênfase sobre as dimensões de experimentação no âmbito da organização da psicologia soviética com o intuito de desvendar seu impacto a esse respeito no campo das produções brasileiras, na interface entre a Psicologia e a Educação. Esse cuidado evita que contribuamos com a manutenção de um projeto teórico e político que anunciamos combater. Pretende-se contribuir com a compreensão de que as atividades de experimentação não se opõem às dimensões da crítica no interior do Materialismo Histórico-Dialético, ao contrário, são, muitas vezes, requeridas por ele.

ABSTRACT This work presents itself as a theoretical essay dedicated to emphasizing the ontological and epistemological Soviet Psychology bases to delimit its necessary methodological properties. We accentuate the risk announced for the field of Historical-Cultural Psychology when we give in to the mistake of emptying the meanings attributed by Vigotski and by the members of his Circle to the Genetic-Experimental Method to the methodological organization in the in Psychology research field. Therefore, the aim of this work is to recover the emphasis about the dimensions of experimentation within the organization of Soviet psychology in order to unveil its impact in this regard in the Brazilian productions field, at the interface between Psychology and Education. This care prevents us from contributing to the maintenance of a theoretical and political project that we announce to be fighting. It is intended to contribute to the understanding that the experimentation activities do not oppose the dimensions of criticism within Historical-Dialectical Materialism, on the contrary, they are often required by it.

RESUMEN Este estudio se presenta como ensayo teórico dedicado a enfatizar las bases ontológicas y epistemológicas de la Psicología Soviética para delimitar sus necesarias propriedades metodológicas. Destacamos el riesgo anunciado para el campo de la Psicología Histórico-Cultural cuando cedemos al equívoco de vaciar los sentidos atribuidos por Vygotsky y por los integrantes de su Círculo al Método Genético-Experimental a la organización metodológica en el campo de las investigaciones en Psicología. Por eso, se propone como objetivo de este estudio el rescate del énfasis sobre las dimensiones de experimentación en el ámbito de la organización de la psicología soviética con el intuito de descubrir su impacto a este respeto en el campo de las producciones brasileñas, en interfaz entre la Psicología y la Educación. Este cuidado evita que contribuyamos con la manutención de un proyecto teórico y político que anunciamos combatir. Se pretende contribuir con la comprensión de que las actividades de experimentación no se oponen a las dimensiones de la crítica en el interior del Materialismo Histórico-Dialéctico, al contrario, son, muchas veces, requeridas por él.

https://doi.org/10.1590/2175-35392021228188

11.

Synchronization of follicular wave emergence does not improve embryonic yield in superovulated ewes
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Brasil, Oscar Oliveira

; Moreira, Nathalia Hack

; Conceição, Fábia Fernanda Cardoso de Barros da

; Souto, Paula Lorena Grangeira

; Silva, Cleidson Manoel Gomes da

; Ramos, Alexandre Floriani

Animal Reproduction

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2021, Volume 18 N. 4 elocation e20210084

Abstract: En | Text: En | PDF: En

Abstract The present study aimed to investigate the effects of a combination of progesterone with different doses of E-17β on following end points: (1) ovarian follicular dynamics and emergence of a new follicular wave, and (2) superovulatory response and embryo yield. In Experiment 1, 28 ewes were randomly divided into four groups (n = 7) to receive either 2.0 mg, 1.0 mg, 0.5 mg or none E-17β one day after insertion of a progesterone device. The different doses of estradiol similarly delayed the moment of follicular emergence (overall mean = 3.1 ± 1.0 days vs. control group = 0.86 ± 1.0 days; P < 0.01), but the emergence of the new wave showed greater synchronization with the 0.5 mg dosage of E-17β. In Experiment 2, sixty-two donor ewes received an internal progesterone release device (day -1) for 7 d and 1 d after the insertion of this device (day 0) were allocated randomly to receive 0.5 mg of E-17β or only the vehicle (control group). Superstimulation was initiated on day 3 with the administration of 133 mg of pFSH in eight decreasing doses. Contrary to expectations, the protocol with the administration of 0.5 mg E-17β did not improve the percentage of donors with > 2 CL, the number of CL and the production of embryos (P > 0.05). It was concluded that the combination of progesterone and 0.5 mg E-17β was more efficient in synchronizing the emergence of the new follicular wave, however this approach seems to be unnecessary in ewe’s superovulation programs.

https://doi.org/10.1590/1984-3143-ar2021-0084

12.

Atitudes e embaraço face ao preservativo em estudantes de enfermagem
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Cunha-Oliveira, Aliete Cristina Gomes Dias Pedrosa da

; Camarneiro, Ana Paula Forte

; Xavier, Beatriz de Oliveira

; Silva, Margarida Alexandra Nunes Carramanho Gomes Martins Moreira da

; Simões, Isabel Maria Henriques

; Cardoso, Ilda Maria Morais Massano

Acta Paulista de Enfermagem

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2021, Volume 34 elocation eAPE01954

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo Conhecer a perceção do risco individual de infeção HIV; avaliar conhecimentos sobre infeção HIV; conhecer atitudes face ao uso do preservativo em função do sexo; conhecer o embaraço na aquisição, negociação e uso do preservativo em função do sexo, independentemente de preservativo masculino ou feminino. Métodos Estudo analítico-transversal. Amostra não probabilística constituída por 102 estudantes de Enfermagem. Instrumentos: questionário sociodemográfico e perceção do risco; teste de conhecimentos; escala de embaraço no uso do preservativo; escala de atitudes face ao uso do preservativo. Resultados A perceção do risco de infeção HIV é favorável/muito favorável para mais de 50% dos jovens e não estatisticamente diferente entre sexos (X2= 2,213; GL= 4, p= 0,697). Dos jovens inquiridos, 86,3% nunca fez teste HIV e 86,1% não se recorda de qualquer campanha de prevenção. O teste de conhecimentos teve resultado global de 83,7%. A dimensão médico-científica mostrou os resultados mais baixos (77,8%). O embaraço na aquisição do preservativo é superior nas inquiridas comparativamente com os inquiridos (t= -2,08; p= 0,04). A atitude face ao uso do preservativo não é significativamente diferente em função do sexo (t= -1,20; p= 0,23). Conclusão Os estudantes têm boa perceção do risco de infeção de HIV, mas baixa adesão à realização do teste e a maioria não se recorda da última campanha de prevenção. Os conhecimentos revelados são elevados, mas necessitam de ser incrementados na dimensão médico-científica. As estudantes revelam mais embaraço do que os estudantes face ao preservativo, porém, as atitudes manifestadas são idênticas. Programas formativos continuam imprescindíveis.

Abstract Objective To investigate the perception of individual risk of HIV infection; to assess knowledge about HIV infection; to learn about condom use attitudes according to gender; to investigate embarrassment about obtaining, negotiating and using condoms according to gender, whether male or female condom. Method This was an analytical cross-sectional study. A non-probabilistic sample was assembled consisting of 102 nursing students. Instruments: sociodemographic and risk perception questionnaire; knowledge test; scale of embarrassment about condom use; condom attitudes scale. Results Perception of risk of HIV infection is favorable/very favorable for more than 50% of young people and there was no statistical difference between the sexes (X 2=2.213; GL= 4, p= 0.697). Of the participants, 86.3% had never been tested for HIV and 86.1% did not recall any HIV prevention campaign. The global result of the knowledge test was 83.7%. The medical-scientific dimension presented the lowest results (77.8%) Embarrassment about obtaining condoms was higher among the women than men (t=-2.08; p=0.04). Attitude towards using condoms was not significantly different between the genders (t= -1.20; p= 0.23). Conclusion The students had a good perception of the risk of HIV infection, but presented low adherence to HIV testing and most did not remember the last prevention campaign. They presented having a high level of knowledge, but they need to improve their knowledge in the medical-scientific dimension. Female students were more embarrassed than the male students about condoms, however, the attitudes towards them were identical. Educational programs continue to be essential.

Resumen Objetivo Conocer la percepción del riesgo individual de infección por VIH. Evaluar los conocimientos sobre infección por VIH. Conocer las actitudes ante el uso del preservativo en función del sexo. Conocer el nivel de vergüenza en la adquisición, negociación y uso de preservativos en función del sexo, tanto preservativos masculinos como femeninos. Métodos Estudio analítico transversal. Muestra no probabilística, formada por 102 estudiantes de enfermería. Instrumentos: cuestionario sociodemográfico y percepción del riesgo, prueba de conocimientos, escala de vergüenza en el uso de preservativos, escala de actitudes ante el uso de preservativos. Resultados La percepción del riesgo de infección por VIH es favorable/muy favorable para más del 50 % de los jóvenes y no es estadísticamente diferente entre sexos (X2= 2,213; GL= 4, p= 0,697). De los jóvenes encuestados, el 86,3 % nunca realizó una prueba de VIH y el 86,1 % no recuerda ninguna campaña de prevención. El resultado global de la prueba de conocimientos fue del 83,7 %. La dimensión médico-científica tuvo los resultados más bajos (77,8 %). La vergüenza en la adquisición de preservativos es superior en las encuestadas en comparación con los encuestados (t= -2,08; p= 0,04). La actitud ante el uso del preservativo no es significativamente diferente en función del sexo (t= -1,20; p= 0,23). Conclusión Los estudiantes tienen una buena percepción del riesgo de infección por VIH, pero una baja adherencia a la realización de pruebas y la mayoría no recuerda la última campaña de prevención. Los conocimientos revelados son altos, pero necesitan aumentar en la dimensión médico-científica. Las estudiantes revelan más vergüenza que los estudiantes ante el preservativo, pero las actitudes manifestadas son idénticas. Los programas educativos continúan siendo imprescindibles.

https://doi.org/10.37689/acta-ape/2021ao01954 1 downloads

13.

Tio2-modified Pinus elliottii: A pine wood presenting increased resistance to water and ultraviolet radiation
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Pereira Acosta, Andrey

; Zanatta, Paula

; Gallio, Ezequiel

; Freire, Nivaldo

; Lazarotto, Marília

; Gomes Jardim, Pedro Lovato

; Gatto, Darci Alberto

; Moreira, Mario Lucio

Maderas. Ciencia y tecnología

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2021, Volume 23 elocation 38

Abstract: En | Text: En | PDF: En

Abstract: The aim of the present study is to subject Pinus elliottii wood specimens to TiO2-based modification in order to make them resistant to water and UV radiation. The microwave-assisted solvothermal method, which is little reported in the literature, was here in use for this purpose. The adopted methodology led to a 1 % mass gain; although it was a low value, it was enough to fully coat the surface of the wood with nanoparticles to the extent of changing its characteristics and turning it into a functional material. The nanoparticle distribution on the surface of the wood changed your natural topography by increasing the surface area and, consequently, increasing the contact angle of the modified wood (approximately 130°). The leaching test showed that the wood remained coated after it was immersed in water, as well as that it did not lose its water-repelling ability. This result demonstrates the stable interaction between the two materials, due to hydroxyl radicals found in them. The coating also protected the wood against UV radiation for 500 hours of intense exposure, besides preserving its initial color. The properties achieved through this simple and fast modification process provide an alternative to help to improve the performance of the herein investigated wood species, mainly for applications in environments subjected to high solar incidence and humidity.

https://doi.org/10.4067/s0718-221x2021000100438 228 downloads

14.

Insect (Hexapoda) diversity in the oceanic archipelago of Fernando de Noronha, Brazil: updated taxonomic checklist and new records
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Rafael, José Albertino

; Limeira-de-Oliveira, Francisco

; Hutchings, Roger William

; Miranda, Gil Felipe Gonçalves

; Silva Neto, Alberto Moreira da

; Somavilla, Alexandre

; Camargo, Alexssandro

; Asenjo, Angélico

; Pinto, Ângelo Parise

; Bello, Ayr de Moura

; Dalmorra, Camila

; Mello-Patiu, Cátia Antunes de

; Carvalho, Claudio José Barros de

; Takiya, Daniela Maeda

; Parizotto, Daniele Regina

; Marques, Dayse Willkenia Almeida

; Cavalheiro, Denis de Oliveira

; Mendes, Diego Matheus de Mello

; Zeppelini, Douglas

; Carneiro, Eduardo

; Lima, Élison Fabrício Bezerra

; Lima, Estevam Cipriano Araújo de

; Godoi, Fabio Siqueira Pitaluga de

; Pessoa, Felipe Arley Costa

; Vaz-de-Mello, Fernando Zagury

; Sosa-Duque, Francisco José

; Flores, Heloísa Fernandes

; Fernandes, Itanna Oliveira

; Silva-Júnior, José Osvaldo

; Gomes, Lucas Roberto Pereira

; Monné, Marcela Laura

; Castro, Marcelo Cutrim Moreira de

; Silva, Marcelo Peixoto Gomes da

; Couri, Márcia Souto

; Gottschalk, Marco Silva

; Soares, Matheus Mickael Mota

; Monné, Miguel Angel

; Rafael, Miriam Silva

; Casagrande, Mirna Martins

; Mielke, Olaf Hermann Hendrik

; Grossi, Paschoal Coelho

; Pinto, Paula Jéssica Costa

; Bartholomay, Pedro Reck

; Sobral, Rafael

; Heleodoro, Raphael Aquino

; Machado, Renato José Pires

; Corrêa, Robson Crepes

; Hutchings, Rosa Sá Gomes

; Ale-Rocha, Rosaly

; Santos, Sandra Duque dos

; Lima, Sheila Pereira de

; Mahlmann, Thiago

; Silva, Vera Cristina

; Fernandes, Daniell Rodrigo Rodrigues

Revista Brasileira de Entomologia

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2020, Volume 64 N. 3 elocation e20200052

Abstract: En | Text: En | PDF: En

ABSTRACT Hexapods, commonly known as insects, are a neglected taxonomic group in the Fernando de Noronha archipelago, with unanswered questions about their species richness and the ecological processes in which they are involved (e.g., colonization, introduction, establishment, and extinction). Herein, we provide an updated Hexapod checklist with current nomenclatural combinations. The entomofauna of the Fernando de Noronha archipelago is currently composed of 453 species in 21 orders. The orders, and their respective number of species, are: Blattaria (9), Coleoptera (118), Collembola (29), Dermaptera (3), Diplura (1), Diptera (134), Embioptera (1), Hemiptera (29), Hymenoptera (59), Isoptera (2), Lepidoptera (25), Mantodea (1), Neuroptera (3), Odonata (5), Orthoptera (11), Phasmatodea (1), Phthiraptera (6), Psocoptera (3), Siphonaptera (1), Thysanoptera (10), and Zygentoma (2). The archipelago has 263 new taxon records (family + genera + species). Thirty-eight species (3.39%) were described from local specimens and most of them are likely endemic species. This study more than doubles our knowledge (from the previous 190 records) of the entomofauna in this large Brazilian archipelago. This study also provides a baseline for studies on its conservation status and for implementing future environmental management programs.

https://doi.org/10.1590/1806-9665-rbent-2020-0052 2462 downloads

15.

Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
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Kobata, Silvia Iovine

; Teixeira, Luiz Eduardo Moreira

; Fernandes, Simone Odilia Antunes

; Faraco, André Augusto Gomes

; Vidigal, Paula Vieira Teixeira

; Araújo, Ivana Duval de

Acta Cirúrgica Brasileira

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2020, Volume 35 N. 8 elocation e202000803

Abstract: En | Text: En | PDF: En

Abstract Purpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables. Results Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05). Conclusion Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.

https://doi.org/10.1590/s0102-865020200080000003 997 downloads

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