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au:MOTA, CAROLINE DA COSTA

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Genetic variability in the neurobiology of nicotine dependence: effects on smoking behavior dependence
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Mota, Caroline de Lima

; Barata-Silva, Cristiane

; Moreira, Josino Costa

; Mitri, Simone

Cadernos Saúde Coletiva

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2023, Volume 31 N. 1 elocation e31010250

Abstract: En | Text: En | PDF: En

Abstract Background Smoking dependence is a chronic disease and a public health problem. The neurobiology of nicotine addiction can explain smoking behavior. This system has genetic variability that has been associated with vulnerability to dependence. Genetic variability in the neurobiology of smoking can help to understand why individuals exposed to drugs may or may not become addicted. Objective This study aims to address genetic variability in the neurobiology of smoking addiction with a focus on polymorphic genes related to the nicotinic response and the dopaminergic reward pathway. Method This work involved a search of the main scientific research on genetic variability in the neurobiology of smoking and its effects on smoking behavior. One hundred and five studies were selected, most of which highlighted polymorphisms in the genes of nicotinic receptors, dopamine receptors, and nicotine metabolism. Results The majority of studies have focused on genes related to the activation of the dopaminergic reward system by nicotine. Combinations between different polymorphisms were also highlighted, showing that interactions can determine a genetic profile of predisposition to smoking addiction. Additionally, gender and ethnicity were identified as relevant factors. Conclusion Knowledge of the genetic bases involved in the individual response to smoking can enable a better understanding of inter-individual differences in smoking behavior, and contribute to improving the treatment of addiction. problem behavior addicted pathway selected receptors metabolism Additionally factors interindividual inter

https://doi.org/10.1590/1414-462x202331010250

Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil
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Silva, Cristiane Barata

; Mota, Caroline de Lima

; Almeida, Yasmin Rocha

; Emídio, Vanessa

; Fonseca, Antonio Sergio A.

; Mitri, Simone

; Moreira, Josino Costa

Cadernos de Saúde Pública

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2019, Volume 35 N. 7 elocation e00198618

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O benzeno é uma das substâncias mais importantes para a biomonitorização, em função do uso disseminado, da contaminação ambiental que resulta da emissão e dos efeitos sobre a saúde humana. O benzeno é classificado pela Agência Internacional de Pesquisa em Câncer (IARC) como carcinógeno conhecido em seres humanos (grupo 1) e está associado ao desenvolvimento de leucemias. Em geral, a população fica exposta a essa substância através da inalação do ar contaminado, que varia de acordo com a localização e a intensidade das fontes potenciais. A indústria petroquímica é uma das fontes mais importantes desse composto. O Município de Duque de Caxias, especificamente o Distrito de Campos Elíseos, no Estado do Rio de Janeiro, Brasil, é sede do Polo Industrial de Campos Elíseos (PICE), um conjunto de mais de 25 indústrias que inclui a segunda maior refinaria de petróleo no Brasil. A contaminação ambiental produzida pelo PICE já é conhecida, mas faltam estudos sobre o impacto na saúde da população local. Foram observadas concentrações de ácido S-fenilmercaptúrico (S-PMA) entre 0,80 e 8,01μg.g-1 creatinina na população local, aparentemente implicadas nas alterações hematológicas também observadas na população exposta. A presença quantificável do S-PMA urinário do metabolismo do benzeno está associada ao fato de 60% dos participantes apresentarem alterações hematológicas específicas, o que pode ser devido à exposição ambiental ao benzeno. As frequências alélicas e genotípicas das enzimas CYP2E1 e NQO1, observadas na população do estudo, foram semelhantes àquelas relatadas em outros estudos. A presença da variante alélica do genótipo NQO1 pode ser um fator de risco para as alterações hematológicas observadas.

Benzene is one of the most important substances for assessment, due to its significant use, the environmental contamination resulting from its emission and the effects on human health. It is classified by the International Agency for Research on Cancer (IARC) as a known carcinogen to humans (group 1) and associated with the development of leukemia. In general, the population is exposed to this substance by inhaling contaminated air, which varies according to the location and intensity of its potential sources. The petrochemical industry is one of the most important sources of this compound. The municipality of Duque de Caxias, specifically the Campos Elíseos district, in Rio de Janeiro State, Brazil, houses the Industrial Complex of Campos Elíseos (PICE), a grouping of over 25 industries, which includes the second largest oil refinery in Brazil. Environmental contamination from the PICE has been recognized, but there is a lack of studies concerning its impact on the health of the surrounding population. S-phenylmercapturic acid (S-PMA) concentrations ranging from 0.80 to 8.01μg.g-1 creatinine were observed in the local population, apparently related to hematological changes also observed in exposed population. The quantifiable presence of urinary S-PMA from the benzene metabolism is associated with the fact that 60% of the participants present specific hematological changes, which may be due to the environmental benzene exposure. The allele and genotype frequencies of the CYP2E1 and NQO1 enzymes observed in the study population were similar to those reported in other studies. The presence of the variant allele in the NQO1 genotype may be a risk factor for the observed hematological changes.

El benceno es una de las sustancias más importantes susceptibles de estudio, debido a su uso significativo, la contaminación ambiental resultante de sus emisiones y sus efectos sobre la salud humana. Está clasificado por el Centro Internacional de Investigaciones sobre el Cáncer (IARC) como un conocido carcinógeno para los humanos (grupo 1) y está asociado con el desarrollo de leucemias. En general, la población está expuesta a esta sustancia por inhalación de aire contaminado, que varía según el lugar y la intensidad de las emisiones. La industria petroquímica es un de las fuentes emisoras más importantes de este compuesto. La municipalidad de Duque de Caxias, específicamente el distrito de Campos Elíseos, en Río de Janeiro, Brasil, alberga el Complejo Industrial de Campos Elíseos (PICE), un conglomerado de más de 25 industrias, que incluye la segunda mayor refinería de petróleo en Brasil. La contaminación ambiental procedente del PICE ya ha sido reconocida, pero es notable la falta de estudios respecto a su impacto en la salud de la población circundante. Se observaron en la población local concentraciones de ácido s-fenilmercaptúrico (SPMA por sus siglas en inglés) que oscilan entre los 0,80 a 8,01μg.g-1 creatinina, aparentemente relacionadas con cambios hematológicos también hallados en la población expuesta. La presencia cuantificable de SPMA en la orina, procedente del metabolismo del benceno, está asociada con el hecho de que un 60% de los participantes presenta cambios específicos hematológicos, los cuales tal vez se deben a la exposición ambiental al benceno. Las frecuencias alélicas y genotípicas del CYP2E1 y enzimas NQO1 observadas en el estudio fueron similares a las reportadas en otros estudios. La presencia de la variante alélica en el genotipo NQO1 podría ser un factor de riesgo para los cambios hematológicos observados.

https://doi.org/10.1590/0102-311x00198618

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Silva, Cristiane Barata

; Mota, Caroline de Lima

; Almeida, Yasmin Rocha

; Emídio, Vanessa

; Fonseca, Antonio Sergio A.

; Mitri, Simone

; Moreira, Josino Costa

Cadernos de Saúde Pública

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2019, Volume 35 N. 7 elocation e00198618

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00198618 1273 downloads

Brazilian recommendations on the safety and effectiveness of the yellow fever vaccination in patients with chronic immune-mediated inflammatory diseases
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Pileggi, Gecilmara Salviato

; Mota, Licia Maria Henrique Da

; Kakehasi, Adriana Maria

; Souza, Alexandre Wagner De

; Rocha, Aline

; Melo, Ana Karla Guedes de

; Fonte, Caroline Araujo M. da

; Bortoletto, Cecilia

; Brenol, Claiton Viegas

; Marques, Claudia Diniz Lopes

; Zaltman, Cyrla

; Borba, Eduardo Ferreira

; Reis, Enio Ribeiro

; Freire, Eutilia Andrade Medeiros

; Klumb, Evandro Mendes

; Christopoulos, Georges Basile

; Laurindo, Ieda Maria M.

; Ballalai, Isabella

; Costa, Izaias Pereira Da

; Michelin, Lessandra

; Valadares, Lilian David de Azevêdo

; Chebli, Liliana Andrade

; Lacerda, Marcus

; Toscano, Maria Amazile Ferreira

; Yazbek, Michel Alexandre

; Vieira, Rejane Maria R. De Abreu

; Magalhães, Renata

; Kfouri, Renato

; Richtmann, Rosana

; Merenlender, Selma Da Costa Silva

; Valim, Valeria

; Assis, Marcos Renato De

; Kowalski, Sergio Candido

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2019, Volume 59 elocation 17

Abstract: En | Text: En | PDF: En

Abstract Background: In Brazil, we are facing an alarming epidemic scenario of Yellow fever (YF), which is reaching the most populous areas of the country in unvaccinated people. Vaccination is the only effective tool to prevent YF. In special situations, such as patients with chronic immune-mediated inflammatory diseases (CIMID), undergoing immunosuppressive therapy, as a higher risk of severe adverse events may occur, assessment of the risk-benefit ratio of the yellow fever vaccine (YFV) should be performed on an individual level. Main body of the abstract: Faced with the scarcity of specific orientation on YFV for this special group of patients, the Brazilian Rheumatology Society (BRS) endorsed a project aiming the development of individualized YFV recommendations for patients with CIMID, guided by questions addressed by both medical professionals and patients, followed an internationally validated methodology (GIN-McMaster Guideline Development). Firstly, a systematic review was carried out and an expert panel formed to take part of the decision process, comprising BRS clinical practitioners, as well as individuals from the Brazilian Dermatology Society (BDS), Brazilian Inflammatory Bowel Diseases Study Group (GEDIIB), and specialists on infectious diseases and vaccination (from Tropical Medicine, Infectious Diseases and Immunizations National Societies); in addition, two representatives of patient groups were included as members of the panel. When the quality of the evidence was low or there was a lack of evidence to determine the recommendations, the decisions were based on the expert opinion panel and a Delphi approach was performed. A recommendation was accepted upon achieving ≥80% agreement among the panel, including the patient representatives. As a result, eight recommendations were developed regarding the safety of YFV in patients with CIMID, considering the immunosuppression degree conferred by the treatment used. It was not possible to establish recommendations on the effectiveness of YFV in these patients as there is no consistent evidence to support these recommendations. Conclusion: This paper approaches a real need, assessed by clinicians and patient care groups, to address specific questions on the management of YFV in patients with CIMID living or traveling to YF endemic areas, involving specialists from many areas together with patients, and might have global applicability, contributing to and supporting vaccination practices. We recommended a shared decision-making approach on taking or not the YFV.

https://doi.org/10.1186/s42358-019-0056-x 1111 downloads

Ingestão de energia e nutrientes segundo consumo de alimentos fora do lar na Região Nordeste: uma análise do Inquérito Nacional de Alimentação 2008-2009
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Cavalcante, Jessica Brito

; Moreira, Tyciane Maria Vieira

; Mota, Caroline da Costa

; Pontes, Carolinne Reinaldo

; Bezerra, Ilana Nogueira

Revista Brasileira de Epidemiologia

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mar 2017, Volume 20 N. 1 Pages 115 - 123

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Introdução: O consumo de alimentos fora do lar vem crescendo no Brasil, sendo associado a escolhas alimentares menos nutritivas. Objetivo: Descrever a ingestão de energia e nutrientes específicos entre consumidores e não consumidores de alimentos fora do lar, na Região Nordeste. Métodos: Foram analisados dados do Inquérito Nacional de Alimentação (INA), provenientes da Pesquisa de Orçamentos Familiares (POF) 2008-2009, em uma amostra de 11.674 indivíduos residentes na Região Nordeste, que forneceram dois registros alimentares em dias não consecutivos, com informação sobre o local de consumo dos alimentos (dentro ou fora do lar). Alimentação fora do lar foi definida como todo alimento adquirido e consumido fora de casa. Modelos de regressão linear foram desenvolvidos para avaliar a relação entre o consumo alimentar fora do lar em um dos dois dias de registro e a ingestão de energia e nutrientes, ajustados por idade, sexo e renda per capita. Resultados: O consumo de alimentos fora do lar, em pelo menos um dos dois dias de registro alimentar, foi reportado por 42% dos indivíduos. Os indivíduos que consomem alimentos fora do lar apresentaram pior ingestão de nutrientes em comparação com os que não consomem alimentos fora do lar, com maior consumo de energia, açúcar livre, gordura saturada, gordura trans e menor ingestão de proteína, ferro e fibra alimentar, independente da idade, sexo e renda (p < 0,05). Conclusão: A alimentação fora do lar no Nordeste contribuiu para uma maior ingestão de energia e uma pior ingestão de nutrientes. Assim, faz-se necessária a elaboração de políticas públicas e estratégias que favoreçam a escolha de alimentos mais saudáveis quando os indivíduos optam por se alimentar fora do lar.

ABSTRACT: Introduction: Away-from-home food consumption has increased in Brazil and is associated with fewer nutritious food choices. Objective: To describe energy and specific nutrient intake among consumers and non-consumer of away-from-home food in the Northeast Region. Methods: A sample of 11,674 individuals from the National Dietary Survey data, which is part of the 2008-2009 Household Budget Survey, from the Northeast Region, was analyzed. Individuals provided two dietary records in nonconsecutive days, informing the place where foods were consumed (at-home or away-from-home). Away-from-home food was defined as foods acquired and consumed away from home. Linear regression models were developed to assess the relationship between away-from-home food consumption in one of the two-day food record and the energy and nutrient intake, adjusted for age, gender, and per capita income. Results: Away-from-home food consumption, in at least one of the two-day food record, was reported by 42% of individuals in the Northeast Region. Individuals who consumed food away from home in the Northeast Region presented poor nutrient intake compared to those who did not report consumption away from home, with higher intake of energy, free sugar, saturated fat, and trans fat and lower intake of protein, iron, and dietary fiber, regardless of age, gender, and income (p < 0.05). Conclusion: Away-from-home food consumption in the Northeast Region contributed to higher energy and poorer nutrient intake. Therefore, the development of public policies and strategies that favor health food choices when individuals eat away from home is necessary.

https://doi.org/10.1590/1980-5497201700010010 2992 downloads

Ingestão de energia e nutrientes segundo consumo de alimentos fora do lar na Região Nordeste: uma análise do Inquérito Nacional de Alimentação 2008-2009
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Cavalcante, Jessica Brito

; Moreira, Tyciane Maria Vieira

; Mota, Caroline da Costa

; Pontes, Carolinne Reinaldo

; Bezerra, Ilana Nogueira

Revista Brasileira de Epidemiologia

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mar 2017, Volume 20 N. 1 Pages 115 - 123

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-5497201700010010 1089 downloads

Towards a personalized risk assessment for exposure of humans to toxic substances
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Pedrete, Thaís de Almeida

; Mota, Caroline de Lima

; Gonçalves, Eline Simões

; Moreira, Josino Costa

Cadernos Saúde Coletiva

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jun 2016, Volume 24 N. 2 Pages 262 - 273

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Há uma grande variabilidade nas respostas observadas entre os organismos expostos a uma substância química perigosa. Essa variabilidade é causada por causas genéticas e / ou ambientais. Esse assunto tem sido intensamente discutido, mesmo nos Estados Unidos, desde que o presidente Obama anunciou o apoio a uma “era da medicina de precisão”, a qual consiste na inclusão de dados genéticos do paciente no projeto do tratamento, impondo uma nova abordagem para avaliação de risco. A avaliação personalizada deve considerar fatores fenotípicos de um indivíduo. Entre os biomarcadores que foram desenvolvidos para avaliar qualquer alteração da estrutura ou função do organismo, os biomarcadores de susceptibilidade têm uma grande importância, uma vez que indicam as características naturais de um dado organismo, que o tornam mais sensíveis a um efeito ou doença adversa específica ou em resposta a uma determinada exposição. As tecnologias “ômicas” permitem a compreensão da relação entre os efeitos químicos e dos mecanismos moleculares de ação. Essas tecnologias “ômicas” são os pilares para a toxicologia personalizada e para a medicina de precisão. Toxicologia preditiva exige uma melhor compreensão dos fatores ou susceptibilidades individuais específicas predisponentes a doenças, permitindo uma avaliação de riscos personalizada e um tratamento médico adequado.

Abstract Great response variability caused by genetic and/or environmental factors has been observed among organisms exposed to hazardous chemicals. This subject has been a topic of intense discussion in the USA since President Obama announced support for an “era of precision medicine”, which consists in the inclusion of genetic data of patients in the treatment design, imposing a new approach to risk assessment. Personalized evaluation must consider the phenotypic factors of an individual. Among the markers that have been developed to evaluate any alteration in the structure or function of organisms, biomarkers of susceptibility are of great importance because they indicate the natural characteristics of a given organism which make it more sensitive to a specific adverse effect or disease, or more responsive to exposure to a specific chemical/drug. The ‘-omics’ technologies provide an insight into the relationship between chemical effects and molecular mechanisms of action. These technologies are the pillars for a personalized toxicology and precision medicine. Predictive toxicology requires a more comprehensive knowledge on specific individual factors or susceptibilities predisposing to diseases, enabling personalized risk assessment and adequate medical treatment.

https://doi.org/10.1590/1414-462X201600020135 2103 downloads

Pb and Cd on growth, leaf ultrastructure and essential oil yield mint (Mentha arvensis L.)
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Jezler, Caroline Nery

; Mangabeira, Pedro Antônio Oliveira

; Almeida, Alex-Alan Furtado de

; Jesus, Raildo Mota de

; Oliveira, Rosilene Aparecida de

; Silva, Delmira da Costa

; Costa, Larissa Correa do Bomfim

Ciência Rural

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mar 2015, Volume 45 N. 3 Pages 392 - 398

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A contaminação de plantas medicinais com Pb e Cd pode afetar o crescimento e a produção de óleo essencial das plantas e representa um risco para quem as consome como medicamento. Este estudo teve como objetivo avaliar os efeitos da absorção e localização de Pb e Cd sobre o crescimento das plantas, aspectos ultraestruturais de folhas e sobre o rendimento e composição química do óleo essencial de M. arvensis, os quais foram aplicados ao solo em concentrações crescentes (8, 16, 32, 64 and 128mg kg-1). Houve absorção diferencial de Pb e Cd por M. arvensis, que se concentraram principalmente nas raízes. O Pb foi encontrado em baixas concentrações nas folhas, enquanto o Cd excedeu largamente o limite de segurança sem demonstrar sintomas de toxicidade. As análises ultraestruturais revelaram o acúmulo de metais em vesículas ao redor de mitocôndrias e a presença de depósitos eletrodensos ao redor de mitocôndrias, núcleo e cloroplastos. As pequenas mudanças causadas pela aplicação de Pb e Cd não foram suficientes para afetar o crescimento das plantas e o rendimento e composição química do óleo essencial de M. arvensis

Contamination of medicinal plants with heavy metals as Pb and Cd can affect the growth and the essential oil production of the plants and represent a risk to those who consume as medicine. This study aimed to evaluate the effects of absorption and localization of Pb and Cd on growth, ultrastructural aspects of leaves and essential oil yield and composition of Mentha arvensis, applied on the soil with increasing concentrations (8, 16, 32, 64 and 128mg kg-1). There was a differential absorption of Pb and Cd by M. arvensis mainly concentrated in the roots. Pb was found in small amounts in the leaves while Cd largely exceeded the safety limit without symptoms of toxicity. The ultrastructural analysis revealed the metal accumulation on vesicles surrounding the mitochondria and the presence of electron dense deposits surrounding the mitochondria, nucleus and chloroplasts. Little changes caused by Pb and Cd application were not enough to affect the growth and essential oil yield and composition of M. arvensis

https://doi.org/10.1590/0103-8478cr20130966 3242 downloads

Proteolytic activity in the adult and larval stages of the human roundworm parasite Angiostrongylus costaricensis
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Rebello, Karina Mastropasqua

; Siqueira, Caroline Reis de

; Ribeiro, Erika Louise

; Valente, Richard Hemmi

; Mota, Ester Maria

; Perales, Jonas

; Neves-Ferreira, Ana Gisele da Costa

; Lenzi, Henrique Leonel

Memórias do Instituto Oswaldo Cruz

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sep 2012, Volume 107 N. 6 Pages 752 - 759

Abstract: En | Text: En | PDF: En

Angiostrongylus costaricensis is a nematode that causes abdominal angiostrongyliasis, a widespread human parasitism in Latin America. This study aimed to characterize the protease profiles of different developmental stages of this helminth. First-stage larvae (L1) were obtained from the faeces of infected Sigmodon hispidus rodents and third-stage larvae (L3) were collected from mollusks Biomphalaria glabrata previously infected with L1. Adult worms were recovered from rodent mesenteric arteries. Protein extraction was performed after repeated freeze-thaw cycles followed by maceration of the nematodes in 40 mM Tris base. Proteolysis of gelatin was observed by zymography and found only in the larval stages. In L3, the gelatinolytic activity was effectively inhibited by orthophenanthroline, indicating the involvement of metalloproteases. The mechanistic class of the gelatinases from L1 could not be precisely determined using traditional class-specific inhibitors. Adult worm extracts were able to hydrolyze haemoglobin in solution, although no activity was observed by zymography. This haemoglobinolytic activity was ascribed to aspartic proteases following its effective inhibition by pepstatin, which also inhibited the haemoglobinolytic activity of L1 and L3 extracts. The characterization of protease expression throughout the A. costaricensis life cycle may reveal key factors influencing the process of parasitic infection and thus foster our understanding of the disease pathogenesis.

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