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Terapia genica: ¿Dónde estamos?, ¿A dónde vamos?
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Expósito, Jesica

; Natera, Daniel

; Carrera, Laura

; Armijo, Jesús

; Rios, Amos

; Nascimento, Andrés

; Ortez, Carlos

Medicina (Buenos Aires)

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oct 2023, Volume 83 Suppl. 4 Pages 13 - 17

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Gene therapy has achieved significant advancements in the treatment of genetic diseases, especially in rare and monogenic diseases. Gene therapies have been de veloped and approved to treat diseases such as spinal muscular atrophy, offering hope to patients and dem onstrating the effectiveness of this therapy. Currently, numerous clinical trials are being conduct ed to evaluate the safety and efficacy of gene therapy in various diseases, particularly in the field of pediatric neurology. These studies are generating encouraging data and contributing to the knowledge on how to im prove gene therapy techniques. Despite the advancements, gene therapy faces significant challenges. It is a costly and technically complex therapy, limiting its accessibility. Addition ally, aspects such as efficient gene delivery, immune response to vectors, and duration of therapeutic re sponse require improvements and are actively being investigated. Regarding the future of gene therapy, advances in gene editing technology, such as CRISPR-Cas9, are ex pected to allow for greater precision and efficiency in gene modification. Research on gene therapy vectors is expected to en hance the delivery capacity and safety of treatments. New generations of viral and non-viral vectors are be ing developed that could overcome current limitations and enable more efficient and precise administration of therapeutic genes.

Resumen La terapia génica ha logrado avances significativos en el tratamiento de enfermedades genéticas, especial mente en enfermedades raras y monogénicas. Se han desarrollado y aprobado terapias génicas para tratar en fermedades como la atrofia muscular espinal, brindando esperanza a los pacientes y demostrando la eficacia de esta terapia. Actualmente, se están realizando numerosos ensayos clínicos para evaluar la seguridad y eficacia de la terapia génica en diversas enfermedades, particularmente en el campo de la neurología pediátrica. Estos estudios están generando datos alentadores y contribuyen al conoci miento sobre cómo mejorar las técnicas de terapia génica. A pesar de los avances, la terapia génica enfrenta desafíos importantes. Es una terapia costosa y téc nicamente compleja, lo que limita su accesibilidad. Además, aspectos como la entrega eficiente de genes, la respuesta inmunológica a los vectores y la duración de la respuesta terapéutica requieren mejoras. se está investigando activamente. En cuanto al futuro de la terapia génica, se espera que los avances en tecnología de edición génica, como CRISPR-Cas9, permitan una mayor precisión y eficiencia en la modificación de genes. Se espera que la investigación en vectores de terapia génica mejore la capacidad de entrega y la seguridad de los tratamientos. Se están desarrollando nuevas ge neraciones de vectores virales y no virales que podrían superar las limitaciones actuales y permitir una admi nistración más eficiente y precisa de genes terapéuticos.

Differences in food consumption of the Brazilian population by race/skin color in 2017–2018
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Costa, Janaína Calu

; Jesus, Amanda Cristina da Silva de

; Jesus, Juliana Giaj Levra de

; Madruga, Mariana Ferreira

; Souza, Thays Nascimento

; Louzada, Maria Laura da Costa

Revista de Saúde Pública

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2023, Volume 57 elocation 4

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Avaliar o consumo alimentar no Brasil por raça/cor da pele da população. MÉTODOS Foram analisados dados de consumo alimentar da Pesquisa de Orçamentos Familiares 2017–2018. Alimentos e preparações culinárias foram agrupados em 31 itens, compondo três grupos principais, definidos por características do processamento industrial: 1 – in natura/minimamente processados, 2 – processados e 3 – ultraprocessados. O percentual de calorias de cada grupo foi estimado por categorias de raça/cor da pele – branca, preta, parda, indígena e amarela –, utilizando-se regressão linear bruta e ajustada para sexo, idade, escolaridade, renda, macrorregião e área. RESULTADOS Nas análises brutas, o consumo de alimentos in natura/minimamente processados foi menor para amarelos [66,0% (Intervalo de Confiança 95% 62,4–69,6)] e brancos [66,6% (IC95% 66,1–67,1)] que para pretos [69,8% (IC95% 68,9–70,8)] e pardos [70,2% (IC95% 69,7–70,7)]. Amarelos consumiram menos alimentos processados, com 9,2% das calorias (IC95% 7,2–11,1) enquanto os demais consumiram aproximadamente 13%. Ultraprocessados foram menos consumidos por pretos [16,6% (IC95% 15,6–17,6)] e pardos [16,6% (IC95% 16,2–17,1)], e o maior consumo ocorreu entre brancos [20,1% (IC95% 19,6–20,6)] e amarelos [24,5% (IC95% 20,0–29,1)]. O ajuste dos modelos reduziu a magnitude das diferenças entre as categorias de raça/cor da pele. A diferença entre pretos e pardos em relação aos brancos diminuiu, de 3 pontos percentuais (pp), para 1,2 pp no consumo de alimentos in natura/minimamente processados e as maiores diferenças remanescentes foram no consumo de arroz e feijão, com maior percentual na alimentação de pretos e pardos. A participação de alimentos processados permaneceu aproximadamente 4 pp menor para amarelos. O consumo de ultraprocessados diminuiu aproximadamente 2 pp para brancos e amarelos; por outro lado, aumentou 1 pp no consumo de pretos, pardos e indígenas. CONCLUSÃO Diferenças no consumo alimentar segundo raça/cor da pele foram encontradas e são influenciadas por condições socioeconômicas e demográficas.

ABSTRACT OBJECTIVE To evaluate food consumption in Brazil by race/skin color of the population. METHODS Food consumption data from the Pesquisa de Orçamentos Familiares (POF – Household Budget Survey) 2017–2018 were analyzed. Food and culinary preparations were grouped into 31 items, composing three main groups, defined by industrial processing characteristics: 1 – in natura/minimally processed, 2 – processed, and 3 – ultra-processed. The percentage of calories from each group was estimated by categories of race/skin color – White, Black, Mixed-race, Indigenous, and Yellow– using crude and adjusted linear regression for gender, age, schooling, income, macro-region, and area. RESULTS In the crude analyses, the consumption of in natura/minimally processed foods was lower for Yellow [66.0% (95% Confidence Interval 62.4–69.6)] and White [66.6% (95%CI 66.1–67.1)] groups than for Blacks [69.8% (95%CI 68.9–70.8)] and Mixed-race people [70.2% (95%CI 69.7–70.7)]. Yellow individuals consumed fewer processed foods, with 9.2% of energy (95%CI 7.2–11.1) whereas the other groups consumed approximately 13%. Ultra-processed foods were less consumed by Blacks [16.6% (95%CI 15.6–17.6)] and Mixed-race [16.6% (95%CI 16.2–17.1)], with the highest consumption among White [20.1% (95%CI 19.6–20.6)] and Yellow [24.5% (95%CI 20.0–29.1)] groups. The adjustment of the models reduced the magnitude of the differences between the categories of race/skin color. The difference between Black and Mixed-race individuals from the White ones decreased from 3 percentage points (pp) to 1.2 pp in the consumption of in natura/minimally processed foods and the largest differences remained in the consumption of rice and beans, with a higher percentage in the diet of Black and Mixed-race people. The contribution of processed foods remained approximately 4 pp lower for Yellow individuals. The consumption of ultra-processed products decreased by approximately 2 pp for White and Yellow groups; on the other hand, it increased by 1 pp in the consumption of Black, Mixed-race, and Indigenous peoples. CONCLUSION Differences in food consumption according to race/skin color were found and are influenced by socioeconomic and demographic conditions.

https://doi.org/10.11606/s1518-8787.2023057004000

Check-All-That-Apply method for sensory characterization of pork from immunocastrated male pigs fed different oil sources
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Silva, Julia Pereira Martins da

; Almeida, Vivian Vezzoni

; Schinckel, Allan Paul

; Meira, Ariana Nascimento

; Moreira, Gabriel Costa Monteiro

; Pian, Laura Woigt

; Campos, Débora de

; Gomes, Julia Dezen

; Gonçales, Janaína Lustosa

; Dargelio, Mariana Damiames Baccarin

; Patinho, Iliani

; Saldaña, Erick

; Contreras-Castillo, Carmen Josefina

; Coutinho, Luiz Lehmann

; Luchiari Filho, Albino

; Nuñez, Amoracyr José Costa

; Cesar, Aline Silva Mello

Scientia Agricola

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2023, Volume 80 elocation e20220019

Abstract: En | Text: En | PDF: En

ABSTRACT In the last decade, other quality attributes have emerged as the main aspects that impact pork consumers acceptance, such as environmentally friendly production, nutritional value, and animal welfare. This study applies a Check-All-That-Apply (CATA) questionnaire for sensory characterization of loins from genetically lean immunocastrated male pigs fed diets containing either a standard commercial diet with 1.5 % soybean oil (control) or 3 % oil from either soybean oil (SO), canola oil (CO), or fish oil (FO) during the growing-finishing phases. Twenty CATA attributes for loin samples were generated. We interviewed 101 consumers to select all the CATA terms that they considered suitable to characterize sensory attributes of longissimus lumborum muscle samples of pigs from each dietary treatment. The CATA results indicated differences among pork loin samples depending on the source and inclusion level of dietary oil. Loins from pigs fed 3 % SO were characterized by a higher frequency of the “juicy texture” attribute (p < 0.05) and a lower frequency of the “dry texture” attribute (p < 0.05) compared to loins from 3 % FO-fed pigs. Moreover, loins from pigs fed 3 % SO had a lower citation frequency of the “tasteless” attribute (p < 0.05) compared to loins from 3 % FO-fed pigs. The attributes “cooked pork meat-like taste”, “juicy texture”, “tender texture”, and “brightness” were placed close to the overall liking. “Tender texture”, “juicy texture”, “pork meat-like” (odor and taste), and “cooked pork meat-like taste” attributes were considered drivers of liking. Feeding genetically lean immunocastrated male pigs with diets containing 3 % SO may be advisable from a pork sensory quality perspective.

https://doi.org/10.1590/1678-992x-2022-0019

Physiological and Biochemical Changes in Immature Seeds of Tabebuia caraiba During Storage
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Santos, Erifranklin Nascimento

; Nóbrega, Jackson Silva

; Silva, Rosemere dos Santos

; Soares, Ana Carolina Sobreira

; Bezerra, Ana Carolina

; Pedrosa, Laura Monteiro

; Bruno, Riselane de Lucena Alcântara

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e23220620

Abstract: En | Text: En | PDF: En

Abstract Studies about the viability and vigor of seeds during storage, especially on the characterization of enzymatic changes, may increase the harvesting efficiency of immature seeds and guarantee their viability for a prolonged period. Therefore, this study aimed to evaluate the behavior of immature seeds of Tabebuia caraiba during storage. For this, thirty selected mother plants at the anthesis stage located in São João do Cariri and Sumé, Paraíba, Brazil were selected. Flowers of each tree were marked, and the fruits were harvested at 35, 42, and 49 days after anthesis (DAA) and characterized according to their maturation stages. The seeds from each maturation stage and city were packed in paper bags and stored in a refrigerator (6 ± 2 °C) for 360 days. The seed quality, seedling vigor, and enzymatic activity of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POX) were evaluated at the beginning of the storage period and intervals of 90 days. The seeds of T. caraiba harvested at 35, 42, and 49 DAA maintained high viability for 360 days of storage. T. caraiba seeds stored for 360 days withstood with high vigor when harvested at 42 DAA. The CAT, SOD, and POX activity was correlated to the deterioration process of the seeds under storage conditions.

https://doi.org/10.1590/1678-4324-2023220620

Electrical Conductivity and Nitrogen:Potassium Ratios from Nutrigation in the Quality of Zucchini Fruits
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Pacheco, Adriano Bicioni

; Duarte, Sergio Nascimento

; Charles, Thaís da Silva

; Nascimento, Jéssica Garcia

; Simões, Ana Laura Toledo

; Campos Júnior, José Eustáquio

; Almeida, Alex Nunes de

; Ricardo, Hugo de Carvalho

; Lopes, Tárcio Rocha

; Jesus, Fernanda Lamede Ferreira de

; Lisboa, Cristiane Fernandes

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e23210845

Abstract: En | Text: En | PDF: En

Abstract The demands of high-quality zucchini fruits by the consumer market make studies regarding the improvement of cultivation systems, such as plant nutrition and salinity tolerance. Considering the demands of the consumer market for the high quality of zucchini fruits, it is necessary studies regarding the improvement of production systems for this improvement, such as nutrition and salinity tolerance to plant. Thus, this study aimed to evaluate the zucchini fruits quality characteristics, grown in soilless, under N:K ratios, and levels of electrical conductivity of the nutrient solution. The experiment was conducted in a protected environment in pots with 8.2 dm3 of volumetric capacity filled with commercial substrate. The trial design adopted was randomized blocks, with three replicates, in a 5x3 factorial scheme, with five levels of electrical conductivity (1.0; 2.0; 3.0; 4.0; and 5.0 dS m-1) and three N:K ratios (2:1; 1:1; and 1:2), both in the nutrient solution. The application of the nutrient solution was by fertigation through drip irrigation. Throughout the experiment, variables related to fruit quality and total plant biomass production were analyzed. The increase of the electrical conductivity in the nutrient solution provided an increase in the values of fruits organoleptic properties. Regarding the nutrient solution N:K ratios, the 1:2 ratio provided larger fruits and a higher percentage of water.

https://doi.org/10.1590/1678-4324-2023210845

Psicologia, Conselho Federal de Psicologia e Covid-19: Enfrentamento às Desigualdades Psicossociais no Brasil
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Rocha, Maria Laura Barros da

; Buarque, Camila do Nascimento Lins

; Bueno, Luciano Domingues

; Falcão, Camila dos Anjos

; Fernandes, Ana Luiza de Moura

; Oliveira, Adélia Augusta Souto de

Psicologia: Ciência e Profissão

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2023, Volume 43 elocation e243766

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract The COVID-19 pandemic imposed transformations in the world daily life, at the micro and macrostructural levels. Its psychological impact destabilizes and highlights Brazilian inequalities and psychosocial vulnerabilities. This is a critical perspective study, based in socio-historical Psychology, aiming to map the positions of Psychology, from different fields, in the face of mental health actions. To this end, the Federal Council of Psychology website is utilized to analyze 62 documents, which resulted in two axes of critical production: 1) the relation between Psychology and the Federal Council of Psychology; and 2) Psychology with society. They reveal the social gap between segments of Brazilian society; ways of excluding prison po7pulation; domestic violence against women and children; and difficulties in accessing social strategies, in education and health, and in overcoming impasses aggravated by the global infection by the new coronavirus. In conclusion, the diversity of public, themes, areas of professional performance, and theoretical references materialize Psychology’s critical and scientific commitment.

Resumen La pandemia del COVID-19 provocó transformaciones globales en lo cotidiano a nivel micro y macroestructural. Su impacto psicológico desestabiliza y destaca las desigualdades y vulnerabilidades psicosociales en Brasil. Esta es una investigación en la perspectiva crítica, basada en la psicología sociohistórica, con el objetivo de mapear las posiciones de la Psicología, procedentes de diferentes campos, frente a las acciones de salud mental. Para este fin, se utiliza el sitio web del Consejo Federal de Psicología para el análisis de 62 documentos, lo que resultó en dos ejes de producción crítica: 1) la relación de la Psicología con el Consejo Federal de Psicología; y 2) de la Psicología con la sociedad. Se revelan la brecha social entre los segmentos de la sociedad brasileña; las formas de exclusión de la población carcelaria; la violencia doméstica contra las mujeres y los niños; y las dificultades para acceder a las estrategias sociales, en la educación y la salud, para superar los impasses agravados por la infección global por el nuevo coronavirus. Se concluye que la diversidad de públicos, temáticas, áreas de actividad y referentes teóricos materializa un compromiso crítico y científico de la Psicología.

Resumo A pandemia da covid-19 impôs transformações no cotidiano mundial, em âmbito micro e macroestrutural. Seu impacto psicológico desestabiliza e evidencia desigualdades e vulnerabilidades psicossociais brasileiras. Configura-se como um estudo de perspectiva crítica, com base na Psicologia Sócio-histórica, com o objetivo de mapear os posicionamentos da Psicologia, vindos de diferentes campos, diante das ações de saúde mental. Para tanto, utiliza-se o site do Conselho Federal de Psicologia para a análise de 62 documentos, que resultaram em dois eixos de produção crítica: 1) a relação da Psicologia com o Conselho Federal de Psicologia; e 2) da Psicologia com a sociedade. Revela-se o abismo social entre segmentos da sociedade brasileira; formas de exclusão da população carcerária; violência doméstica contra as mulheres e as crianças; dificuldades de acesso a estratégias sociais, na educação e na saúde, e de superação dos impasses acirrados com a infecção global pelo novo coronavírus. Conclui-se que a diversidade de públicos, temáticas, áreas de atuação e referenciais teóricos materializa um compromisso crítico e científico da Psicologia.

https://doi.org/10.1590/1982-3703003243766

Ephemeroptera (Insecta) from the metropolitan region of Santarém, Pará, Brazil
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Oliveira, Laura Almeida de

; Couceiro, Sheyla Regina Marques

; Nascimento, Jeane Marcelle Cavalcante do

Biota Neotropica

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2023, Volume 23 N. 1 elocation e2022143

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract With the objective of improving the knowledge about Ephemeroptera in the North region of Brazil, the group’s first survey was carried out for the metropolitan region of Santarém, Pará, Brazil. The specimens analyzed were collected from 2019 to 2020 in 27 aquatic environments distributed in the region. The nymphs were captured in the streams with aquatic entomological nets, in addition to manual collection on the substrates. Adults were collected using light traps and flight intercept traps. To complement the inventory, a bibliographic survey of species previously recorded in the area was carried out. For this, the Taxonomic Catalog of Fauna of Brazil, the website Ephemeroptera in South America and scientific articles were consulted. As a result, eight families, 23 genera and 31 species/morphospecies were recorded for the region, with 13 new records for Pará and 19 for the metropolis of Santarém. This study demonstrates the relevance of surveys for the knowledge of biodiversity and for understanding the geographic distribution of taxa.

Resumo Com o objetivo de aprimorar o conhecimento sobre Ephemeroptera na região Norte do Brasil, foi realizado o primeiro levantamento do grupo para a região metropolitana de Santarém, Pará, Brazil. Os espécimes analisados foram coletados de 2019 a 2020 em 27 ambientes aquáticos distribuídos na região. As ninfas foram capturadas nos riachos com redes entomológicas aquáticas, além da coleta manual nos substratos. Os adultos foram coletados por meio de armadilhas luminosas e armadilhas de interceptação de voo. Para complementar o inventário, foi realizado o levantamento bibliográfico das espécies previamente registradas na área. Para isso, foram consultados o Catálogo Taxonômico da Fauna do Brasil, o site Ephemeroptera na América do Sul e artigos científicos. Como resultado, oito famílias, 23 gêneros e 31 espécies/morfoespécies foram registradas para a região, sendo 13 novos registros para o Pará e 19 para a metrópole de Santarém. Este estudo demonstra a relevância dos levantamentos para o conhecimento da biodiversidade e para a compreensão da distribuição geográfica dos táxons.

https://doi.org/10.1590/1676-0611-bn-2022-1437

Práticas de cuidado em saúde com crianças quilombolas: percepção dos cuidadores
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Souza, Lauro Nascimento de

; Nogueira, Laura Maria Vidal

; Rodrigues, Ivaneide Leal Ataíde

; Pinheiro, Ana Kedma Correa

; Andrade, Erlon Gabriel Rego de

Escola Anna Nery

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2023, Volume 27 elocation e20220166

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective to analyze, in caregivers’ perception, the health care practices provided to Quilombola children. Method an exploratory-descriptive, qualitative study carried out in the Quilombola community Santa Rita de Barreira, São Miguel do Guamá, Pará, Brazil. Data were produced between July and September 2021, with caregivers of children aged zero to five years, through individual interviews guided with a semi-structured instrument. For analysis, Microsoft Office Excel 2019 and the Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires 0.7, alpha 2 were used, through Descending Hierarchical Classification. Results eighteen female caregivers participated, aged between 20 and 67 years. They related care to disease prevention and treatment, life habits, health services access and popular practices that value traditional medicine. Conclusions and implications for practice women’s knowledge and actions expressed influences from their culture, their beliefs and their ways of interpreting and symbolizing reality. Recognizing and questioning Quilombola practices in child care is a challenge that goes beyond the biomedical, reductionist and stigmatizing discourse, a context in which it is necessary to expand the interdisciplinary debate on the subject.

Resumen Objetivo analizar, en la percepción de los cuidadores, las prácticas de atención a la salud que se brindan a niños quilombolas. Método estudio exploratorio-descriptivo, cualitativo, realizado en la comunidad quilombola Santa Rita de Barreira, São Miguel do Guamá, Pará, Brasil. Los datos fueron recolectados entre julio y septiembre de 2021, con cuidadores de niños de cero a cinco años, a través de entrevistas individuales guiadas con instrumento semiestructurado. Para el análisis, se utilizó el programa Microsoft Office Excel 2019 y el software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires 0.7, alpha 2, a través de la Clasificación Jerárquica Descendente. Resultados participaron 18 cuidadoras, con edades entre 20 y 67 años. Relacionaron el cuidado con la prevención y tratamiento de enfermedades, hábitos de vida, acceso a los servicios de salud y prácticas populares que valoran la medicina tradicional. Conclusiones e implicaciones para la práctica los saberes y acciones de las mujeres expresaron la influencia de su cultura, sus creencias y sus formas de interpretar y simbolizar la realidad. Reconocer y cuestionar las prácticas quilombolas en el cuidado de los niños es un desafío que va más allá del discurso biomédico, reduccionista y estigmatizador, contexto en el que es necesario ampliar el debate interdisciplinario sobre el tema.

Resumo Objetivo analisar, na percepção dos cuidadores, as práticas de cuidado em saúde prestadas às crianças quilombolas. Método estudo exploratório-descritivo, qualitativo, realizado na comunidade quilombola Santa Rita de Barreira, São Miguel do Guamá, Pará, Brasil. Os dados foram produzidos entre julho e setembro de 2021, com cuidadores de crianças de zero a cinco anos, por meio de entrevistas individuais guiadas com instrumento semiestruturado. Para análise, utilizou-se o Microsoft Office Excel 2019 e o software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires 0.7, alpha 2, por meio da Classificação Hierárquica Descendente. Resultados participaram 18 cuidadores do sexo feminino, com idade entre 20 e 67 anos. Relacionaram o cuidado à prevenção e ao tratamento de doenças, aos hábitos de vida, ao acesso aos serviços de saúde e às práticas populares que valorizam a medicina tradicional. Conclusões e implicações para a prática os saberes e as ações das mulheres expressaram influências de sua cultura, suas crenças e seus modos de interpretar e simbolizar a realidade. Reconhecer e problematizar as práticas quilombolas no cuidado às crianças é um desafio que ultrapassa o discurso biomédico, reducionista e estigmatizante, contexto no qual é preciso ampliar o debate interdisciplinar sobre o tema.

https://doi.org/10.1590/2177-9465-ean-2022-0166pt

Differences in food consumption of the Brazilian population by race/skin color in 2017–2018
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Costa, Janaína Calu

; Jesus, Amanda Cristina da Silva de

; Jesus, Juliana Giaj Levra de

; Madruga, Mariana Ferreira

; Souza, Thays Nascimento

; Louzada, Maria Laura da Costa

Revista de Saúde Pública

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2023, Volume 57 elocation 4

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.11606/s1518-8787.2023057004000

10.

Factors associated with Trichomonas vaginalis infection in reproductive-aged women attending cervical screening in southeast of Brazil
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Pinto, Gabriel Vitor da Silva

; Bolpet, Aline do Nascimento

; Martin, Laura Fernandes

; Moço, Natália Prearo

; Ramos, Bruna Ribeiro de Andrade

; Silva, Mariana de Castro

; Duarte, Marli Teresinha Casamassimo

; Tristão, Andréa da Rocha

; Silva, Márcia Guimarães da

; Marconi, Camila

Brazilian Journal of Infectious Diseases

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2023, Volume 27 N. 4 elocation 102794

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Sexually Transmitted Infections (STIs) can be caused by viruses, bacteria, and parasites. The World Health Organization estimated more than 300 million new global cases of curable STIs among individuals of reproductive age. Infection by Trichomonas vaginalis is one of the most prevalent curable STL Despite the current treatments available, the diagnosis of T. vaginalis can be difficult, and the resistance to the treatment increased concern for the healthcare system. Objectives: The aim of this study was to determine the prevalence and factors associated with Trichomonas vaginalis infection among women of reproductive age attending community-based services for cervical screening. Patients and methods: A total of 1477 reproductive-aged women attending 18 Primary Health Care Units in Botucatu, Brazil, from September to October 2012, were enrolled. A structured questionnaire was used for individual face-to-face interviews for obtaining data on sociodemographic, gynecologic, and obstetrics history, sexual and hygiene practices, among others. Cervicovaginal samples were obtained for detection of T. vaginalis by culture using Diamond's medium and microscopic vaginal microbiota classification according to Nugent. A multivariable logistic regression analysis was carried out to estimate Odds Ratios (OR) and 95% Confidence Intervals (95% CI) for the association between participants’ sociodemographic, behavioral factors, and clinical factors with T. vaginalis infection. Results: Median age of study participants was 33 years (ranging from 18 to 50). The overall prevalence of T. vaginalis infection was 1.3% (n = 20). Several factors were independently associated with T. vaginalis infection, such as self-reporting as black or Pardo for ethnicity (OR = 2.70; 95% CI 1.03–7.08), smoking (OR=3.18; 95% CI 1.23–8.24) and having bacterial vaginosis (OR = 4.01; 95%CI = 1.55–10.38) upon enrollment. A protective effect of higher educational level (having high school degree) was observed (OR = 0.16; 95% CI 0.05–0.53). Conclusions: Our data suggest that screening programs to correctly detect T. vaginalis infection can be helpful to guide prevention strategies to the community. Our study supports an association between abnormal vaginal microbiota and T. vaginalis infection.

https://doi.org/10.1016/j.bjid.2023.102794

11.

VACINAÇÃO NA GRAVIDEZ: CONSTRUÇÃO E VALIDAÇÃO DE TECNOLOGIA EDUCACIONAL
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Nascimento, Camilla Cristina Lisboa do

; Rodrigues, Ivaneide Leal Ataíde

; Nogueira, Laura Maria Vidal

; Nunes, Heliana Helena de Moura

; Brasil, Gisele de Brito

; Moraes, Carlos Marcelo da Silva

; Pereira, Alexandre Aguiar

Cogitare Enfermagem

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2023, Volume 28 elocation e90023

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to build and validate the content of an educational technology to guide pregnant women about immunization. Method: a methodological study carried out from December 2020 to October 2021 in Belém, Pará, Brazil. It consisted of two stages: Construction through an Integrative Literature Review and face and content validation with 16 judges using a Likert scale for data collection and the Content Validity Index for analysis. Results: a double-sided table flipbook was created on immunization, which was assessed by 100% of the judges as relevant, with a mean Content Validity Index per block greater than 0.86. Conclusion: the technology was built with technically correct information and validated by experts in the respective areas. It is understood that its use will ease the prenatal Nursing practice, considering it to be a tool capable of arousing interest and encouraging dialogue between professionals and pregnant women, solving doubts in the immunization context.

RESUMEN Objetivo: elaborar y validar el contenido de una tecnología educativa para orientar a mujeres embarazadas sobre la inmunización. Método: estudio metodológico realizado de diciembre de 2020 a octubre de 2021, en Belén, Pará, Brasil. Constó de dos etapas: Elaboración por medio de Revisión Integradora de la Literatura y validación de apariencia y contenido por 16 jueces usando una escala Likert para la recolección de datos y el Índice de Validez de Contenido para el análisis. Resultados: se creó un cuadernillo doble faz sobre inmunización, que fue evaluado como relevante por el 100% de los jueces, con un Índice de Validez de Contenido promedio por sección superior a 0,86. Conclusión: tecnología elaborada con información técnicamente correcta y validada por expertos en las respectivas áreas. Se considera que su uso facilitará la práctica de la enfermería prenatal, es una herramienta capaz de despertar interés y fomentar el diálogo entre profesionales y gestantes, resolviendo dudas en el contexto de la inmunización.

RESUMO: Objetivo: construir e validar o conteúdo de uma tecnologia educacional para orientar gestantes sobre imunização. Método: estudo metodológico realizado em dezembro de 2020 a outubro de 2021, em Belém, Pará, Brasil. Constou de duas etapas: Construção por meio de Revisão Integrativa da Literatura e validação de aparência e conteúdo com 16 juízes utilizando escala Likert para coleta dos dados e o Índice de Validade de Conteúdo para análise. Resultados: elaborou-se um álbum seriado de mesa, com dupla face, sobre imunização que foi avaliado por 100% dos juízes como pertinente com média do Índice de Validade de Conteúdo por blocos superior a 0,86. Conclusão: tecnologia construída com informações tecnicamente corretas e validada junto a especialistas nas respectivas áreas. Entende-se que seu uso facilitará a prática da enfermagem no pré-natal, considerando ser ferramenta capaz de despertar interesse e favorecer o diálogo entre profissionais e gestantes, sanando dúvidas no contexto da imunização.

https://doi.org/10.1590/ce.v28i0.90023

12.

Human immunodeficiency virus infection in pregnant women and its correlation with socioeconomic determinants
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Trindade, Lidiane de Nazaré Mota

; Nogueira, Laura Maria Vidal

; Rodrigues, Ivaneide Leal Ataíde

; Guimarães, Ricardo José de Paula Souza e

; Souza, Maria Helena do Nascimento

Revista da Escola de Enfermagem da USP

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2023, Volume 57 elocation e20220321

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To analyze the spatial pattern of human immunodeficiency virus infection in pregnant women and its correlation with socioeconomic determinants. Method: Ecological study, carried out with cases of human immunodeficiency virus infection in pregnant women in the state of Pará, Brazil, from 2010 to 2017. Rate analysis was performed using the empirical Bayesian method and univariate local Moran. Bivariate analyses were used to examine the correlation between infection and socioeconomic determinants. Results: High rates of infection were observed in municipalities in the mesoregions of Southeast of Pará and Metropolitan area of Belém. A significant spatial correlation was found between human immunodeficiency virus infection rates in pregnant women and human development index indicators (I = 0.2836; p < 0.05), average income (I = 0.6303; p < 0.05), and illiteracy rate (I = 0.4604; p < 0.05). Conclusion: The spatial pattern of human immunodeficiency virus infection in pregnant women correlated to socioeconomic determinants highlights the need to restructure public policies for the control and prevention of AIDS virus that take into account the socioeconomic factors of this specific population and locoregional disparities in Pará.

RESUMEN Objetivo: Analizar el estándar espacial de la infección por el virus de la inmunodeficiencia humana en mujeres embarazadas y su correlación con determinantes socioeconómicos. Método: Estudio ecológico, realizado con casos de infección por el virus de la inmunodeficiencia humana en mujeres embarazadas en el estado de Pará, Brasil, de 2010 a 2017. El análisis de tasas se realizó mediante el método bayesiano empírico y Moran local univariado. Se emplearon análisis bivariados para examinar la correlación entre la infección y los determinantes socioeconómicos. Resultados: Se observaron altas tasas de infección en municipios de las mesorregiones Sudeste de Pará y Metropolitana de Belém. Se identificó una correlación espacial significativa entre las tasas de infección por el virus de la inmunodeficiencia humana en mujeres embarazadas y los indicadores del índice de desarrollo humano (I = 0,2836; p < 0,05), ingreso medio (I = 0,6303; p < 0,05) y tasa de analfabetismo (I = 0,4604; p < 0,05). Conclusión: El estándar espacial de la infección por el virus de la inmunodeficiencia humana en mujeres embarazadas correlacionado con determinantes socioeconómicos refuerza la necesidad de reestructurar políticas públicas para el control y la prevención del virus del SIDA que tengan en cuenta los factores socioeconómicos de esta población específica y las disparidades locorregionales en Pará.

RESUMO Objetivo: Analisar o padrão espacial da infecção pelo vírus da imunodeficiência humana em gestantes e sua correlação com os determinantes socioeconômicos. Método: Estudo ecológico, realizado com casos de infecção pelo vírus da imunodeficiência humana em gestantes no estado do Pará, Brasil, de 2010 a 2017. A análise das taxas foi realizada por meio do método bayesiano empírico e Moran local univariado. As análises bivariadas foram empregadas para examinar a correlação entre a infecção e os determinantes socioeconômicos. Resultados: Verificaram-se altas taxas da infecção em municípios das mesorregiões Sudeste Paraense e Metropolitana de Belém. Identificou-se correlação espacial significativa entre as taxas de infecção pelo vírus da imunodeficiência humana em gestantes e os indicadores índice de desenvolvimento humano (I = 0,2836; p < 0,05), renda média (I = 0,6303; p < 0,05) e taxa de analfabetismo (I = 0,4604; p < 0,05). Conclusão: O padrão espacial da infecção pelo vírus da imunodeficiência humana em gestantes correlacionada aos determinantes socioeconômicos reforça a necessidade de reestruturação de políticas públicas de controle e prevenção do vírus da AIDS que atentem para os fatores socioeconômicos desse público específico e disparidades locorregionais no Pará.

https://doi.org/10.1590/1980-220x-reeusp-2022-0321en

13.

Dados de Vida Real sobre o Uso da Hidroxicloroquina ou da Cloroquina Combinadas ou Não à Azitromicina em Pacientes com Covid-19: Uma Análise Retrospectiva no Brasil
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Souza-Silva, Maíra Viana Rego

; Pereira, Daniella Nunes

; Pires, Magda Carvalho

; Vasconcelos, Isabela Muzzi

; Schwarzbold, Alexandre Vargas

; Vasconcelos, Diego Henrique de

; Pereira, Elayne Crestani

; Manenti, Euler Roberto Fernandes

; Costa, Felício Roberto

; Aguiar, Filipe Carrilho de

; Anschau, Fernando

; Bartolazzi, Frederico

; Nascimento, Guilherme Fagundes

; Vianna, Heloisa Reniers

; Batista, Joanna d’Arc Lyra

; Machado-Rugolo, Juliana

; Ruschel, Karen Brasil

; Ferreira, Maria Angélica Pires

; Oliveira, Leonardo Seixas de

; Menezes, Luanna Silva Monteiro

; Ziegelmann, Patricia Klarmann

; Tofani, Marcela Gonçalves Trindade

; Bicalho, Maria Aparecida Camargos

; Nogueira, Matheus Carvalho Alves

; Guimarães-Júnior, Milton Henriques

; Aguiar, Rúbia Laura Oliveira

; Rios, Danyelle Romana Alves

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 9 elocation e20220935

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Despite no evidence showing benefits of hydroxychloroquine and chloroquine with or without azithromycin for COVID-19 treatment, these medications have been largely prescribed in Brazil. Objectives To assess outcomes, including in-hospital mortality, electrocardiographic abnormalities, hospital length-of-stay, admission to the intensive care unit, and need for dialysis and mechanical ventilation, in hospitalized COVID-19 patients who received chloroquine or hydroxychloroquine, and to compare outcomes between those patients and their matched controls. Methods A retrospective multicenter cohort study that included consecutive laboratory-confirmed COVID-19 patients from 37 Brazilian hospitals from March to September 2020. Propensity score was used to select matching controls by age, sex, cardiovascular comorbidities, and in-hospital use of corticosteroid. A p-value <0.05 was considered statistically significant. Results From 7,850 COVID-19 patients, 673 (8.6%) received hydroxychloroquine and 67 (0.9%) chloroquine. The median age in the study group was 60 years (46 - 71) and 59.1% were women. During hospitalization, 3.2% of patients presented side effects and 2.2% required therapy discontinuation. Electrocardiographic abnormalities were more prevalent in the chloroquine/hydroxychloroquine group (13.2% vs. 8.2%, p=0.01), and the long corrected QT interval was the main difference (3.6% vs. 0.4%, p<0.001). The median hospital length of stay was longer in the HCQ/CQ + AZT group than in controls (9.0 [5.0, 18.0] vs. 8.0 [4.0, 14.0] days). There was no statistical differences between groups in intensive care unit admission (35.1% vs. 32.0%; p=0.282), invasive mechanical ventilation support (27.0% vs. 22.3%; p=0.074) or mortality (18.9% vs. 18.0%; p=0.682). Conclusion COVID-19 patients treated with chloroquine or hydroxychloroquine had a longer hospital length of stay, when compared to matched controls. Intensive care unit admission, invasive mechanical ventilation, dialysis and in-hospital mortality were similar.

Resumo Fundamento Apesar da ausência de evidência mostrando benefícios da hidroxicloroquina e da cloroquina combinadas ou não à azitromicina no tratamento da covid-19, esses medicamentos têm sido amplamente prescritos no Brasil. Objetivos Avaliar desfechos, incluindo moralidade hospitalar, alterações eletrocardiográficas, tempo de internação, admissão na unidade de terapia intensiva, e necessidade de diálise e de ventilação mecânica em pacientes hospitalizados com covid-19 que receberam cloroquina ou hidroxicloroquina, e comparar os desfechos entre aqueles pacientes e seus controles pareados. Métodos Estudo multicêntrico retrospectivo do tipo coorte que incluiu pacientes com diagnóstico laboratorial de covid-19 de 37 hospitais no Brasil de março a setembro de 2020. Escore de propensão foi usado para selecionar controles pareados quanto a idade, sexo, comorbidades cardiovasculares, e uso de corticosteroides durante a internação. Um valor de p<0,05 foi considerado estatisticamente significativo. Resultados Dos 7850 pacientes com covid-19, 673 (8,6%) receberam hidroxicloroquina e 67 (0,9%) cloroquina. A idade mediana no grupo de estudo foi 60 (46-71) anos e 59,1% eram mulheres. Durante a internação, 3,2% dos pacientes apresentaram efeitos adversos e 2,2% necessitaram de interromper o tratamento. Alterações eletrocardiográficas foram mais prevalentes no grupo hidroxicloroquina/cloroquina (13,2% vs. 8,2%, p=0,01), e o prolongamento do intervalo QT corrigido foi a principal diferença (3,6% vs. 0,4%, p<0,001). O tempo mediano de internação hospitalar foi maior no grupo usando CQ/HCQ em relação aos controles (9,0 [5,0-18,0] vs. 8,0 [4,0-14,0] dias). Não houve diferenças estatisticamente significativas entre os grupos quanto a admissão na unidade de terapia intensiva (35,1% vs. 32,0%; p=0,282), ventilação mecânica invasiva (27,0% vs. 22,3%; p=0,074) ou mortalidade (18,9% vs. 18,0%; p=0,682). Conclusão Pacientes com covid-19 tratados com cloroquina ou hidroxicloroquina apresentaram maior tempo de internação hospitalar, em comparação aos controles. Não houve diferença em relação a admissão em unidade de terapia intensiva, necessidade de ventilação mecânica e mortalidade hospitalar.

https://doi.org/10.36660/abc.20220935

14.

Construct Validity of the Brazilian Version of the Dyadic Adjustment Scale
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Hernandez, José Augusto Evangelho

; Peçanha, Raphael Fischer

; Soares, Laura Costa Mattos

; Lima, Isabela da Costa Nascimento de

Psicologia: Teoria e Pesquisa

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2023, Volume 39 elocation e39510

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study sought evidence of construct validity for the Brazilian versions of the Dyadic Adjustment Scale and Revised Dyadic Adjustment Scale. A total of 448 individuals participated in the research, 253 women and 195 men from several regions of Brazil who had been cohabiting with their marital partners for an average of 14.7 years. Several proposed models for the measure were tested in Structural Equation Modeling. In the Confirmatory Factor Analysis, the four-factor and hierarchical models of the Revised Dyadic Adjustment Scale showed good overall adjustments. Evidence of factor, convergent, and discriminant validity were also found. Composite reliability revealed adequate levels of internal consistency. The Multigroup Confirmatory Factor Analysis demonstrated a strong measurement invariance model for men and women.

Resumo Este estudo verificou evidências de validade de construto para as versões brasileiras da Dyadic Adjustment Scale e da Revised Dyadic Adjustment Scale. Participaram da pesquisa 448 indivíduos, 253 mulheres e 195 homens de diversas regiões nacionais que coabitavam com seus parceiros conjugais há 14,7 anos, em média. Na Análise Fatorial Confirmatória, foram testados seis modelos anteriormente propostos para a medida. Entre eles, quatro fatores correlacionados e hierárquico multidimensional da Revised Dyadic Adjustment Scale apresentaram os melhores ajustes gerais. Foram encontradas evidências de validades fatorial, convergente e discriminante e níveis adequados de consistência interna por meio da confiabilidade composta. Também foi demonstrada a invariância de medida forte do modelo da RDAS entre homens e mulheres.

https://doi.org/10.1590/0102.3772e39510.en

15.

CORP(O)RALIDADE COMO METODOLOGIA: COMPOSIÇÕES POSSÍVEIS ENTRE ESCREVIVÊNCIA E FILOSOFIA UBUNTU
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Santos, Hebert Silva dos

; Santos, Loíse Lorena do Nascimento

; Quadros, Laura Cristina de Toledo

; Tsallis, Alexandra Cleopatre

Psicologia & Sociedade

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2023, Volume 35 elocation e277081

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract This article explores "Corp(O)ralidade" as a decolonial scientific methodology. "Corpo" means "body" in Portuguese, therefore the concept unites body and orality in a word-juggling. It is based on the main author's experience in Afro dance workshops at COART - UERJ in 2019 and online classes with Eliete Miranda during the covid-19 pandemic in 2020-2021. The work is the result of a Master's thesis research (2020-2022) that reflects on the construction of a decolonial methodology. "Corp(O)ralidade" emphasizes orality in Afro dance, transmitting ancestral knowledge of the Orixás. Actor-Network Theory is the methodology, valuing everyone in the construction of knowledge. The concept of Ubuntu highlights collectivity and solidarity, connecting us to others. Conceição Evaristo's "Escrevivência" encompasses black orality and values the knowledge of black women. The research aims to present "Corp(O)ralidade" as a decolonial methodology that combines the understanding of Ubuntu philosophy and the orality of "escrevivência", both present in Afro dance.

Resumen Este artículo explora la “Corp(O)ralidade” como metodología científica decolonial, vinculada a la filosofía Ubuntu y la “escrevivência” de Conceição Evaristo. Basado en talleres de danza afro en COART - UERJ en 2019 y clases en línea de Eliete Miranda durante la pandemia de covid-19 en 2020-2021. Resulta de una investigación de tesis de maestría (2020-2022) que refleja la construcción de una metodología decolonial. “Corp(O)ralidade” enfatiza la oralidad en la danza afro, transmitiendo conocimientos ancestrales de los Orixás. La Teoría Actor-Red es la metodología, valorando a todos en la construcción del conocimiento. El concepto Ubuntu destaca la colectividad y la solidaridad. La “escrevivência” de Conceição Evaristo comprende la oralidad negra y valora el conocimiento de las mujeres negras. La investigación presenta “Corp(O)ralidade” como metodología decolonial que une la filosofía Ubuntu y la oralidad de la “escrevivência”, presentes en la danza afro.

Resumo Este artigo explora a Corp(O)ralidade como metodologia científica decolonial, ligada à filosofia Ubuntu e a escrevivência de Conceição Evaristo. Baseado na experiência do autor principal, em oficinas de dança afro no COART - UERJ, em 2019, e nas aulas on-line de Eliete Miranda durante a pandemia de covid-19 em 2020-2021. O trabalho é fruto de uma pesquisa de dissertação de mestrado (2020-2022), que reflete a construção de uma metodologia decolonial. A Corp(O)ralidade enfatiza a oralidade na dança afro, transmitindo os saberes ancestrais dos Orixás. A Teoria Ator-Rede é a metodologia, uma vez que valoriza todos na construção do conhecimento. O conceito Ubuntu destaca coletividade e solidariedade, conectando-nos aos outros. A Escrevivência de Conceição Evaristo compreende a oralidade negra e valoriza o conhecimento das mulheres negras. A pesquisa busca trazer a Corp(O)ralidade enquanto uma metodologia decolonial, que une os entendimentos da filosofia Ubuntu e a oralidade da escrevivência, ambos presentes da dança afro.

https://doi.org/10.1590/1807-0310/2023v35e277081

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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