SUMMARY BACKGROUND: Cerebrovascular accident (or stroke) and ischemic heart disease are the the major causes of death in the world. It is estimated that about 85% of strokes are ischemic in origin. Reperfusion therapy in the acute phase of ischemic stroke with a recombinant human tissue plasminogen activator is effective, but some factors influence the success of this treatment. OBJECTIVE: The aim of this study was to evaluate clinical aspects and possible determinants for reperfusion after venous thrombolysis. METHODS: This is a retrospective, cross-sectional, observational study based on a review of hospital records of inpatients diagnosed with ischemic stroke treated with intravenous thrombolysis, the main outcome being reperfusion or not. RESULTS: Data from this study revealed a predominance of females in the group of reperfused patients and males in the non-reperfused group, both maintaining moderate severity on the National Institutes of Health Stroke Scale and admission without statistical significance (p>0.18). In addition, the mean admission severity score was 13.2 for the group of reperfused patients and 14.2 for those not reperfused, and the mean ejection fraction of both groups was within normal functionality, with a mean of 0.50 for reperfused patients and 0.62 for non-reperfused patients. CONCLUSION: We found an association between successful venous chemical thrombolysis reperfusion and lower mortality in patients with acute stroke.

ABSTRACT Purpose: To evaluate the quality of life and stress level related to visual function following pediatric cataract surgery in a Brazilian public hospital. Methods: This prospective study analyzed children aged 6-14 years old who underwent cataract surgery. The Childhood Stress Scale and Children’s Visual Function Questionnaire (CVFQ) were used to assess stress levels and quality of life, respectively. Both instruments were applied by two psychologists before and after the surgery. Eye examination was performed by two ophthalmologists. Preoperative and postoperative data were compared. Results: In total, 23 children (32 eyes) were enrolled in the study, of which 9 had bilateral cataracts. The average age group at the time of surgery was 9.65 ± 2.26 (6-14) years old. One month after the surgery, the spherical equivalent was -0.90 ± 1.66D, and the corrected distance visual acuity was 0.13 ± 0.10 (0-0.3) LogMAR in bilateral cases and 0.50 ± 0.39 (0-1.3) LogMAR in unilateral cases (p<0.01). According to the Childhood Stress Scale, 77.7% of the bilateral cases and 57.1% of the unilateral cases had stable stress levels, and 34.7% of the children improved their stress level. The analysis of the CVFQ was based on scores for general health, general vision health, competence, personality, and treatment. After cataract surgery, 78.2% of the patients had improved or maintained CVFQ scores in the general health domain; 82.6%, general vision health; 95.6%, competence; 56.5%, personality; and 78.2%, treatment. Conclusion: Pediatric cataract surgery improves the visual function and the quality of life even in patients undergoing surgical procedures, without increasing the stress levels.

RESUMO Objetivo: Avaliar a qualidade de vida e o nível de estresse relacionada à função visual após a cirurgia de catarata pediátrica em um hospital público brasileiro. Métodos: Estudo prospectivo em crianças de seis a 14 anos submetidas à cirurgia de catarata. A Escala de Stresse Infantil e o Questionário de Função Visual em Crianças foram usados para avaliar o nível de estresse e a qualidade de vida, respectivamente. Ambos os instrumentos foram aplicados por duas psicólogas antes e após a cirurgia. O exame oftalmológico foi realizado por dois oftalmologistas. Os dados coletados no pré e pós-operatório foram comparados. Resultados: Vinte e três crianças (32 olhos) foram incluídas no estudo, nove delas apresentavam catarata bilateral. A média de idade na cirurgia foi de 9,65±2,26 (6 a 14) anos. Um mês após a cirurgia, o equivalente esférico foi de -0,90 ± 1,66D e a acuidade visual corrigida a distância foi de 0,13 ± 0,10 (0-0,3) LogMAR em casos bilaterais e 0,50 ± 0,39 (0-1,3) LogMAR em casos unilaterais (p<0.01). De acordo com a Escala de Stresse Infantil, 77,7% dos casos de catarata bilaterais, e 57,1% dos casos unilaterais mantiveram o nível de estresse e 34,7% das crianças melhoraram o nível de estresse. A análise do Questionário de Função Visual em Crianças foi baseada em pontuações para saúde geral, saúde geral da visão, competência, personalidade e tratamento. Após a cirurgia de catarata, 78,2% dos pacientes melhoraram ou mantiveram o escore do Questionário de Função Visual em Crianças na saúde geral, 82,6% na saúde geral da visão, 95,6% na competência, 56,5% na personalidade e 78,2% no tratamento. Conclusão: A cirurgia de catarata pediátrica melhora a função visual e a qualidade de vida em pacientes submetidos a procedimento cirúrgico, sem aumentar o nível de estresse.

Abstract Introduction: recent studies have suggested the use of neck circumference as a parameter capable of identifying risks of cardiometabolic complications and the accumulation of truncal fat caused by both antiretroviral therapy and the lifestyle of people with the human immunodeficiency virus (HIV). Objective: to investigate the relationship between neck circumference and anthropometric indicators and to assess cardiometabolic risk and truncal obesity through proposed cut-off points. Methods: cross-sectional study including 233 people with HIV. Demographic, socioeconomic, lifestyle and clinical data were collected using a structured questionnaire. The anthropometric evaluation included: weight, height, body mass index (BMI) measurements; waist (WC), neck (NC), arm and arm muscle circumferences; triceps and subscapular skinfolds and their sum. ROC curves were constructed to determine the accuracy of NC in predicting cardiometabolic risk in people living with HIV. Results: the sample was 57.5 % male, with a mean age of 38.4 years (95 % CI: 37.2-39.7 years). NC showed a positive and significant correlation with all anthropometric variables analyzed (p < 0.05), and a higher correlation strength with WC and BMI. The NC cut-off point selected as a predictor of risk of cardiac metabolic complications and truncal obesity in women was ≥ 32.4 cm, considering both WC and BMI. For men, the NC cut-off points were different when considering WC (≥ 39.6 cm) and BMI (≥ 38.1 cm) as a reference. It is worth noting that NC performed well in ROC curve analysis for men, while in women it was a poor performance. Conclusion: NC proved to be a promising indicator in the assessment of nutrition and health of people living with HIV, especially in men.

Resumen Introducción: estudios recientes han sugerido el uso de la circunferencia del cuello como parámetro capaz de identificar los riesgos de complicaciones cardiometabólicas y la acumulación de grasa troncal causados tanto por la terapia antirretroviral como por el estilo de vida de las personas con el virus de la inmunodeficiencia humana (VIH). Objetivo: investigar la relación entre la circunferencia del cuello y los indicadores antropométricos y evaluar el riesgo cardiometabólico y la obesidad troncal a través de los puntos de corte propuestos. Métodos: estudio transversal que incluyó a 233 personas con VIH. Se recogieron datos demográficos, socioeconómicos, de estilo de vida y clínicos mediante un cuestionario estructurado. La evaluación antropométrica incluyó: medidas de peso, altura, índice de masa corporal (IMC); circunferencias de cintura (CC), cuello (CN), brazo (CA) y músculo del brazo (MCB); pliegues cutáneos del tríceps y subescapular y su suma. Se construyeron curvas ROC para determinar la precisión de la CN en la predicción del riesgo cardiometabólico en personas que viven con el VIH. Resultados: el 57,5 % de la muestra eran varones, con una edad media de 38,4 años (IC 95 %: 37,2-39,7 años). La CN mostró una correlación positiva y significativa (p < 0,05) con todas las variables antropométricas analizadas, y una mayor fuerza de correlación con la CC y el IMC. El punto de corte de la CN seleccionado como predictor de riesgo de complicaciones metabólicas cardiacas y obesidad troncular en mujeres fue ≥ 32,4 cm, considerando tanto la CC como el IMC. En el caso de los hombres, los puntos de corte de la CN fueron diferentes al considerar como referencia la CC (≥ 39,6 cm) y el IMC (≥ 38,1 cm). Cabe destacar que la CN obtuvo buenos resultados en el análisis de la curva ROC en el caso de los hombres, mientras que en el de las mujeres fue deficiente. Conclusión: la CN demostró ser un indicador prometedor en la evaluación de la nutrición y la salud de las personas que viven con el VIH, especialmente en los hombres.

RESUMO Objetivo: Avaliar a qualidade de vida e o nível de estresse relacionada à função visual após a cirurgia de catarata pediátrica em um hospital público brasileiro. Métodos: Estudo prospectivo em crianças de seis a 14 anos submetidas à cirurgia de catarata. A Escala de Stresse Infantil e o Questionário de Função Visual em Crianças foram usados para avaliar o nível de estresse e a qualidade de vida, respectivamente. Ambos os instrumentos foram aplicados por duas psicólogas antes e após a cirurgia. O exame oftalmológico foi realizado por dois oftalmologistas. Os dados coletados no pré e pós-operatório foram comparados. Resultados: Vinte e três crianças (32 olhos) foram incluídas no estudo, nove delas apresentavam catarata bilateral. A média de idade na cirurgia foi de 9,65±2,26 (6 a 14) anos. Um mês após a cirurgia, o equivalente esférico foi de -0,90 ± 1,66D e a acuidade visual corrigida a distância foi de 0,13 ± 0,10 (0-0,3) LogMAR em casos bilaterais e 0,50 ± 0,39 (0-1,3) LogMAR em casos unilaterais (p<0.01). De acordo com a Escala de Stresse Infantil, 77,7% dos casos de catarata bilaterais, e 57,1% dos casos unilaterais mantiveram o nível de estresse e 34,7% das crianças melhoraram o nível de estresse. A análise do Questionário de Função Visual em Crianças foi baseada em pontuações para saúde geral, saúde geral da visão, competência, personalidade e tratamento. Após a cirurgia de catarata, 78,2% dos pacientes melhoraram ou mantiveram o escore do Questionário de Função Visual em Crianças na saúde geral, 82,6% na saúde geral da visão, 95,6% na competência, 56,5% na personalidade e 78,2% no tratamento. Conclusão: A cirurgia de catarata pediátrica melhora a função visual e a qualidade de vida em pacientes submetidos a procedimento cirúrgico, sem aumentar o nível de estresse.

ABSTRACT Purpose: To evaluate the quality of life and stress level related to visual function following pediatric cataract surgery in a Brazilian public hospital. Methods: This prospective study analyzed children aged 6-14 years old who underwent cataract surgery. The Childhood Stress Scale and Children’s Visual Function Questionnaire (CVFQ) were used to assess stress levels and quality of life, respectively. Both instruments were applied by two psychologists before and after the surgery. Eye examination was performed by two ophthalmologists. Preoperative and postoperative data were compared. Results: In total, 23 children (32 eyes) were enrolled in the study, of which 9 had bilateral cataracts. The average age group at the time of surgery was 9.65 ± 2.26 (6-14) years old. One month after the surgery, the spherical equivalent was -0.90 ± 1.66D, and the corrected distance visual acuity was 0.13 ± 0.10 (0-0.3) LogMAR in bilateral cases and 0.50 ± 0.39 (0-1.3) LogMAR in unilateral cases (p<0.01). According to the Childhood Stress Scale, 77.7% of the bilateral cases and 57.1% of the unilateral cases had stable stress levels, and 34.7% of the children improved their stress level. The analysis of the CVFQ was based on scores for general health, general vision health, competence, personality, and treatment. After cataract surgery, 78.2% of the patients had improved or maintained CVFQ scores in the general health domain; 82.6%, general vision health; 95.6%, competence; 56.5%, personality; and 78.2%, treatment. Conclusion: Pediatric cataract surgery improves the visual function and the quality of life even in patients undergoing surgical procedures, without increasing the stress levels.

Abstract This study characterized the beverage of passion fruit and whey protein added with Lacticaseibacillus rhamnosus GG (LGG). The acidity, pH, soluble solids, protein, phenolic compounds, and color of the sample did not differ during the 28 days at 5°C. The LGG counts in the beverage remained >7.70 log CFU/mL during the evaluation period. However, the LGG count was significantly reduced after the in vitro simulated gastrointestinal tract (GIT) evaluation (reduction of 5 logarithmic cycles after processing). On the other hand, the LGG resistance to GIT increased during the shelf-life of the beverage (LGG count of ~ 4.0 log CFU/mL after 28 days). In addition, the LGG count after GIT increased by approximately 2.0 logarithmic cycles when microencapsulation and fermentation technologies were used in beverage processing. Thus, the product has the potential to be commercialized, due to high viability of LGG use to increase the resistance of LGG to GIT.

ABSTRACT BACKGROUND: Exposure to air pollutants and illness by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection can cause serious pulmonary impairment. OBJECTIVE: To identify a possible association between exposure to air pollutants and hospitalizations due to SARS-Cov-2. DESIGN AND SETTING: Ecological time-series study carried out in Taubaté, Tremembé, and Pindamonhangaba in 2020 and 2021. METHODS: Study with Sars-Cov-2 hospitalizations with information on hospitalization date, sex and age of the subjects, duration of hospitalization, type of discharge, and costs of these hospitalizations. Statistical analysis was performed through a negative binomial regression, with data on pollutant concentrations, temperature, air relative humidity, and hospitalization date. Coefficients obtained by the analysis were transformed into relative risk for hospitalization, which estimated hospitalizations excess according to an increase in pollutant concentrations. RESULTS: There were 1,300 hospitalizations and 368 deaths, with a predominance of men (61.7%). These data represent an incidence rate of 250.4 per 100,000 inhabitants and 28.4% hospital lethality. Significant exposure (P value < 0.05) occurred seven days before hospital admission (lag 7) for nitrogen dioxide (NO2) (relative risk, RR = 1.0124) and two days before hospital admission for PM2.5 (RR = 1.0216). A 10 μg/m3 in NO2 concentration would decrease by 320 hospitalizations and » US $ 240,000 in costs; a 5 μg/m3 in PM2.5 concentration would decrease by 278 hospitalizations and » US $ 190,000 in costs. CONCLUSION: An association between exposure to air pollutants and hospital admission due to Sars-Cov-2 was observed with excess hospitalization and costs for the Brazilian public health system.

ABSTRACT Objective: to identify the non-invasive technologies and care strategies used by obstetric nurses to encourage freedom of movement and positioning in the parturition process. Method: A descriptive and qualitative study, with 20 obstetric nurses working in public obstetric services in Rio de Janeiro - Brazil. Data were collected from May to July 2021 through semi-structured interviews and submitted to thematic analysis. Results: the participants use the encouragement to ambulate and perform pelvic movements and squats, also suggesting specific positions, especially vertical ones. As strategies, they orient about the benefits of these technologies and respect the choice of the expectant women, interfering, however, in cases of obstetric complications. Conclusion: The incentive to freedom of movement and positioning in parturition happens with the offer of different non-invasive technologies in a care relationship with clarified and shared decision-making processes, which promote autonomy and ensure the right to safe and respectful assistance.

RESUMEN Objetivo: Identificar las tecnologías no invasivas y las estrategias de cuidados utilizadas por las enfermeras obstétricas para favorecer la libertad de movimientos y el posicionamiento en el proceso de parto. Método: Estudio descriptivo y cualitativo, con 20 enfermeras obstétricas que trabajan en servicios públicos de obstetricia en Rio de Janeiro - Brasil. Los datos se recopilaron entre mayo y julio de 2021 mediante entrevistas semiestructuradas y se sometieron a un análisis temático. Resultados: los participantes utilizan el estímulo para el desplazamiento y la realización de movimientos pélvicos y de agachamiento, sugiriendo también posiciones específicas, especialmente verticales. Como estrategias, se orientan hacia los beneficios de las tecnologías y respetan la elección de las parturientas, interfiriendo, además, en los casos de complicaciones obstétricas. Conclusión: el incentivo a la libertad de movimiento y posicionamiento en el parto pasa por la oferta de diferentes tecnologías no invasivas en una relación asistencial con procesos de toma de decisión clarificados y compartidos, que promuevan la autonomía y garanticen el derecho a una asistencia segura y respetuosa.

RESUMO Objetivo: identificar as tecnologias não invasivas e estratégias de cuidado utilizadas pelas enfermeiras obstétricas para o incentivo à liberdade de movimentos e posicionamentos no processo de parturição. Método: Estudo descritivo e qualitativo, com 20 enfermeiras obstétricas que atuam em serviços obstétricos públicos do Rio de Janeiro - Brasil. Os dados foram coletados no período de maio a julho de 2021 por meio de entrevistas semiestruturadas e submetidos à análise temática. Resultados: as participantes utilizam o estímulo à deambulação e à realização de movimentos pélvicos e agachamentos, sugerindo também posições específicas, especialmente, verticalizadas. Como estratégias, orientam quanto aos benefícios destas tecnologias e respeitam a escolha das parturientes, interferindo, porém, em casos de intercorrências obstétricas. Conclusão: o incentivo à liberdade de movimentos e posicionamentos na parturição acontece com o oferecimento de diferentes tecnologias não invasivas em uma relação de cuidado com processos decisórios esclarecidos e compartilhados, que promovem a autonomia e asseguram o direito à assistência segura e respeitosa.

Abstract Objective to discuss the facilitating and limiting factors of nurses’ performance in controlling COVID-19 in childbirth care. Methods a descriptive and qualitative study, with 20 nurse-midwives from public services in the state of Rio de Janeiro. Data were collected from May to July 2021, through semi-structured interviews, and submitted to thematic content analysis. Results as facilitating factors there are: physical installations and resources that provide individualized use; protocol implementation; reorganization of collective environment use; and preference for care that does not require instruments or nurses’ continuous presence. As limiting factors, the following stand out: high demand for care; restricted accommodation and inadequate ventilation; lack of resources; resistance to wearing a mask; nurses’ difficulty in maintaining physical distance in care; and increase in interventionist practices among certain professionals. Conclusions and implications for practice services that underwent adaptations in environments, with available resources, co-responsibility regarding sanitary measures and where nurse-midwives modified their care process, presented better conditions to protect health and mitigate COVID-19 transmission, with attention to environment, humanization and women’s rights during childbirth.

Resumen Objetivo discutir los factores facilitadores y limitantes de la actuación de los enfermeros en el control de la COVID-19 en la atención al parto. Métodos estudio descriptivo y cualitativo, con 20 parteras de servicios públicos del estado de Río de Janeiro. Los datos fueron recolectados de mayo a julio de 2021, a través de entrevistas semiestructuradas, y sometidos a análisis de contenido temático. Resultados como factores facilitadores, se encuentran: instalaciones físicas y recursos que brindan un uso individualizado; implementación de protocolos; reorganización del uso de los entornos colectivos; y preferencia por cuidados que no requieran instrumental o la presencia continua de la enfermera. Como limitantes, se destacan: la alta demanda de atención; alojamiento restringido y ventilación inadecuada; falta de recursos; resistencia a usar mascarilla; dificultades de las enfermeras para mantener la distancia física en el cuidado; y el aumento de las prácticas intervencionistas entre determinados profesionales. Conclusiones e implicaciones para la práctica los servicios que sufrieron adaptaciones en los ambientes, con recursos disponibles, corresponsabilidad en las medidas sanitarias y donde las matronas modificaron su proceso de atención, presentan mejores condiciones para proteger la salud y mitigar la transmisión de la COVID-19, con atención al ambiente, la humanización y los derechos de la mujer durante el parto.

Resumo Objetivo discutir os fatores facilitadores e limitadores da atuação das enfermeiras no controle da COVID-19 na assistência ao parto. Métodos estudo descritivo e qualitativo, com 20 enfermeiras obstétricas de serviços públicos do estado do Rio de Janeiro. Os dados foram coletados de maio a julho de 2021, por entrevistas semiestruturadas, e submetidos à análise de conteúdo temática. Resultados como fatores facilitadores, têm-se: instalações físicas e recursos que proporcionam o uso individualizado; implementação de protocolos; reorganização do uso de ambientes coletivos; e preferência por cuidados que não requerem instrumentos ou a presença contínua da enfermeira. Como limitadores, apontam-se: a alta demanda assistencial; acomodações restritas e ventilação inadequada; carência de recursos; resistência ao uso de máscara; dificuldades das enfermeiras em manter o distanciamento físico nos cuidados; e incremento de práticas intervencionistas entre determinados profissionais. Conclusões e implicações para a prática serviços que passaram por adequações nos ambientes, com recursos disponíveis, corresponsabilização acerca das medidas sanitárias e onde as enfermeiras obstétricas modificaram seu processo de cuidar, apresentam melhores condições para proteger a saúde e mitigar a transmissão da COVID-19, com atenção à ambiência, humanização e aos direitos das mulheres no parto.

Abstract Background Fibroblast-like synoviocytes (FLS) play a prominent role in rheumatoid synovitis and degradation of the extracellular matrix through the production of inflammatory cytokines and metalloproteinases (MMPs). Since animal models are frequently used for elucidating the disease mechanism and therapeutic development, it is relevant to study the ultrastructural characteristics and functional responses in human and mouse FLS. The objective of the study was to analyze ultrastructural characteristics, Interleukin-6 (IL-6) and Metalloproteinase-3 (MMP-3) production and the activation of intracellular pathways in Fibroblast like synoviocytes (FLS) cultures obtained from patients with rheumatoid arthritis (RA) and from mice with collagen-induced arthritis (CIA). Methods FLSs were obtained from RA patients (RA-FLSs) (n = 8) and mice with CIA (CIA-FLSs) (n = 4). Morphology was assessed by transmission and scanning electron microscopy. IL-6 and MMP-3 production was measured by ELISA, and activation of intracellular signaling pathways (NF-κB and MAPK: p-ERK1/2, p-P38 and p-JNK) was measured by Western blotting in cultures of RA-FLSs and CIA-FLSs stimulated with tumor necrosis factor-alpha (TNF-α) and IL-1β. Results RA-FLS and CIA-FLS cultures exhibited rich cytoplasm, rough endoplasmic reticula and prominent and well- developed Golgi complexes. Transmission electron microscopy demonstrated the presence of lamellar bodies, which are cytoplasmic structures related to surfactant production, in FLSs from both sources. Increased levels of pinocytosis and numbers of pinocytotic vesicles were observed in RA-FLSs (p < 0.05). Basal production of MMP-3 and IL-6 was present in RA-FLSs and CIA-FLSs. Regarding the production of MMP-3 and IL-6 and the activation of signaling pathways, the present study demonstrated a lower response to IL-1β by CIA-FLSs than by RA-FLSs. Conclusion This study provides a comprehensive understanding of the biology of RA-FLS and CIA-FLS. The differences and similarities in ultrastructural morphology and important inflammatory cytokines shown, contribute to future in vitro studies using RA-FLS and CIA-FLS, in addition, they indicate that the adoption of CIA-FLS for studies should take careful and be well designed, since they do not completely resemble human diseases.

Objective: To describe the methodological and operational aspects of the Cancer Surveillance Project and its associated factors: population-based and hospital-based registry (VIGICAN), in Mato Grosso (MT). Methods: VIGICAN was divided into two projects: an extension one, which updated the data from the Population-Based Cancer Registry (RCBP) of MT in the period 2008 to 2016; and one of research, which collected primary data, through individual interviews and analysis of medical records of people with a diagnosis of cancer, aged 18 years or over, treated at reference hospitals for oncology. To analyze the factors associated with cancer, the following variables were collected: socioeconomic and demographic, social support, status and health behavior, and environmental exposure. Results: In the períod from 2008 to 2016, approximately one hundred thousand cases of cancer (incident and prevalent) were reported in the RCBP Cuiabá and Interior. After validation procedures, fifty thousand incident cases were chosen. The survey interviewed 1,012 patients, 38.2% living in the municipalities of Cuiabá and Várzea Grande, 60.4% in the interior of the state and 1.4% in other states. Preliminary data revealed that the majority were female (55.0%) and younger than 60 years (54.3%). Among those interviewed, 7.2% reported smoking tobacco, 15.5% consumed alcoholic beverages (15.5%) and 32.7% lived close to crops. Conclusion: The development of these projects allowed the integration of education with health services and will enable the recognition of specificities and different exposure scenarios and factors associated with cancer in the Mato Grosso territory.

Objetivo: Descrever os aspectos metodológicos e operacionais do Projeto Vigilância do Câncer e seus fatores associados: registro de base populacional e hospitalar (VIGICAN), em Mato Grosso (MT). Métodos: O VIGICAN se desdobrou em dois projetos: um de extensão, que atualizou os dados dos Registros de Câncer de Base Populacional (RCBP) de MT no período de 2008 a 2016; e um de pesquisa, que coletou dados primários, por meio de entrevistas individuais e análise de prontuários de pessoas com diagnóstico de câncer, com 18 anos ou mais, atendidas em hospitais de referência para oncologia. Para analisar os fatores associados ao câncer, foram coletadas as seguintes variáveis: socioeconômicas e demográficas, suporte social, situação e comportamentos de saúde e exposição ambiental. Resultados: No período de 2008 a 2016, foram notificados nos RCBP Cuiabá e Interior, aproximadamente, 100 mil casos de câncer (incidentes e prevalentes). Após procedimentos de validação, foram eleitos 50 mil casos incidentes. A pesquisa entrevistou 1.012 pacientes, sendo 38,2% residentes nos municípios de Cuiabá e Várzea Grande, 60,4% no interior do estado e 1,4% em outros estados. Os dados preliminares revelaram que a maioria era do sexo feminino (55,0%) e tinha menos de 60 anos (54,3%). Entre os entrevistados, 7,2% relataram fumar tabaco, 15,5% consumiam bebidas alcoólicas (15,5%) e 32,7% moravam próximos a lavouras. Conclusão: O desenvolvimento desses projetos permitiu a integração do ensino com os serviços de saúde e possibilitará o reconhecimento das especificidades e diferentes cenários de exposição e fatores associados ao câncer do território mato-grossense.

Abstract Changes in land use and land cover (LULC) can result in significant changes in a hydrographic basin flow regime. Future projections about LULC and its interference with water availability help to identify extreme events in advance and help propose appropriate management measures. Thus, this study aimed to make the LULC projection for the year 2030 for the Alto Rio Grande (ARG) sub-basin, located in Southeastern Brazil. This region was chosen because of its intense water resources use and for having recently faced water scarcity as result of prolonged droughts and inadequate water resources management. To identify the LULC trend for the year 2030, the Land Change Modeler (LCM) was used, the map obtained was inserted in the Soil and Water Assessment Tool (SWAT) model previously calibrated and validated for the region’ environmental and climatic conditions. The ARG sub-basin was affected by heavy rains in 2011, which resulted in changes in the landscape due to landslides. This particularity of the region contributed to the projection of LULC for the year 2030 to present an increase in forest and pastures to the agricultural areas detriment. When evaluating the impacts of these changes in water availability, it was observed that the SWAT model presented, for the same rainfall conditions, a reduction in peak streamflows of up to 59% and a reduction in the average monthly flow of up to 63% in 2030 in relation to the LULC observed in 2017. Thus, this study provides an important contribution by identifying a considerable reduction in water availability. These results will help to formulate strategies for water resources management and the adoption of measures to promote water security in the region.

Resumen Los cambios en el uso y la cobertura del suelo pueden resultar en cambios significativos en el régimen del flujo de una cuenca hidrográfica. Los estudios predictivos sobre el uso del suelo y su interferencia con la disponibilidad del agua ayudan a identificar eventos extremos con anticipación a fin de proponer medidas de gestión adecuadas. De esta forma, este estudio tuvo como objetivo realizar la predicción del uso del suelo para el año 2030 para la subcuenca del Alto Río Grande (ARG), ubicada en el sureste de Brasil. Esta región fue elegida por el uso intenso de los recursos hídricos y por haber enfrentado, recientemente, escasez de agua como resultado de sequías prolongadas y una gestión inadecuada de los recursos hídricos. Para la predicción del uso del suelo en 2030 se utilizó el Land Change Modeler (LCM), el mapa obtenido se insertó en el modelo Soil and Water Assessment Tool (SWAT) previamente calibrado y validado para las condiciones ambientales y climáticas de la región. La subcuenca ARG fue afectada por fuertes lluvias en 2011 que resultaron en cambios en el paisaje debido a deslizamientos de tierra. Esta particularidad de la región contribuyó para que la predicción del uso del suelo para el año 2030 presente un aumento de bosques y pastos en detrimento de las áreas agrícolas. Al evaluar los impactos de estos cambios en la disponibilidad del agua, se observó que el modelo SWAT presentó, para las mismas condiciones de precipitación, una reducción en los caudales pico de hasta 59% y una reducción en el caudal promedio mensual de hasta 63% en 2030 en relación con el uso del suelo observado en 2017. Es decir, este estudio hace un aporte importante al identificar una reducción considerable en la disponibilidad del agua. Estos resultados ayudarán a formular estrategias para la gestión de los recursos hídricos y la adopción de medidas para promover la seguridad hídrica en la región.

Resumo Objetivo Avaliar o aprendizado de pessoas com deficiência visual após participação em jogo educativo sobre drogas psicoativas. Métodos Pesquisa quase-experimental, realizada em uma associação de cegos e em laboratório experimental de ensino de saúde de uma universidade, com 60 cegos maiores de 18 anos, com cegueira ou baixa visão, alfabetizados em Braille ou capazes de ler textos com letras ampliadas. Foi aplicado o jogo educativo de tabuleiro “Drogas: jogando limpo”, que contempla conteúdo sobre o conceito, tipos de drogas, prejuízos, fatores de risco, situações envolvendo o uso das drogas e fatores de proteção/prevenção. Aprendizagem foi avaliada em entrevista individual, antes e após aplicação do jogo com questões organizadas por níveis de complexidades. Comparação do número de acertos avaliados pelo teste McNemar. Resultados Questões de baixa complexidade apresentaram diferença significativa (p=0,0001) nos acertos após uso do jogo e elevado índice de acertos antes e após (81,7% e 98,3%). Não houve diferença estatística nas questões de média e alta complexidade. Conclusão O jogo Drogas: jogando limpo, contribuiu, de forma significativa, para a aprendizagem das pessoas com deficiência visual, representando estratégia de inclusão de individuos com deficiência no acesso à informação.

Abstract Objective Evaluate the learning of visually disabled people after participating in an educational game about psychoactive drugs. Methods Quasi-experimental research, conducted in an association of the blind and in an experimental laboratory of health teaching at a university, involving 60 blind people over the age of 18, blind or with low vision, literate in Braille or able to read texts with enlarged letters. The educational board game “Drugs: playing fair” was applied, which covers content on the concept, types of drugs, harms, risk factors, situations involving the use of drugs and protection/prevention factors. Learning was evaluated in an individual interview, before and after the application of the game, with questions organized by levels of complexity. Comparison of the number of hits evaluated using the McNemar test. Results Questions of low complexity presented a significant difference (p=0.0001) in the hits after using the game and a high index of hits before and after (81.7% and 98.3%). There was no statistical difference in the medium and high complexity questions. Conclusion The game Drugs: playing fair, significantly contributed to the learning of people with visual disabilities, representing a strategy to include individuals with disabilities in the access to information.

Resumen Objetivo Evaluar el aprendizaje de personas con discapacidad visual después de la participación en juego educativo sobre drogas psicoactivas. Métodos Investigación cuasi experimental, realizada en una asociación de ciegos y en un laboratorio experimental de enseñanza de salud de una universidad, con 60 ciegos de más de 18 años, con ceguera o con baja visión, alfabetizados en Braille con capacidad para leer textos con letras ampliadas. Se aplicó un juego educativo de tablero “Drogas: jugando limpio”, que contempla contenidos sobre el concepto, tipos de drogas, perjuicios, factores de riesgo, situaciones que involucran el uso de drogas y factores de protección/prevención. El aprendizaje fue evaluado en entrevista individual, antes y después de la aplicación del juego con preguntas organizadas por niveles de complejidad. Comparación del número de aciertos evaluados por la prueba McNemar. Resultados Preguntas de baja complejidad presentaron diferencias significativas (p=0,0001) en los aciertos después del uso del juego y elevado índice de aciertos antes y después (81,7 % y 98,3 %). No hubo diferencia estadística en las preguntas de mediana y alta complejidad. Conclusión El juego Drogas: jugando limpio, contribuyó, de forma significativa, para el aprendizaje de las personas con discapacidad visual, lo que representa una estrategia de inclusión de personas con discapacidad para el acceso a la información.

RESUMO Objetivo: Descrever aspectos clínicos e epidemiológicos de crianças e adolescentes infectados pelo SARS-CoV-2 no município de Taubaté (SP) de março a novembro de 2020. Métodos: Estudo transversal com dados secundários obtidos no Setor de Vigilância Epidemiológica de casos confirmados em residentes do município e consulta de prontuários de pacientes que foram atendidos em hospitais de Taubaté, com idade entre 0 e 19 anos. Realizaram-se os testes de qui-quadrado, comparação de proporções e t de Student, sendo considerados nível de significância alfa <5%. Resultados: Notificaram-se 677 casos no período estudado, correspondendo a 10,1% do total de casos notificados no município. O teste rápido de anticorpos foi o teste mais utilizado, seguido de RT-PCR e sorologia. Sintomas foram descritos em 57,7% dos casos, sendo febre e tosse os mais frequentes. Diarreia apresentou associação com faixa etária < 4 anos, e febre, tosse, cefaleia, odinofagia, ageusia, anosmia, mialgia e dispneia tiveram associação com faixa etária de 10 a 19 anos. No período estudado, não ocorreu nenhum óbito por COVID-19 na faixa etária de 0 a 19 anos de residentes do município. Conclusões: O estudo conseguiu identificar a proporção de acometimento da COVID-19 em crianças e adolescentes no município, e a doença teve comportamento leve e boa evolução. Os principais sintomas foram febre e tosse, destacando-se diarreia nas crianças mais jovens e cefaleia, odinofagia, anosmia, ageusia e mialgia nos adolescentes.

Abstract Objective: To describe clinical and epidemiological aspects of children and adolescents infected with the SARS-CoV-2 in the Municipality of Taubaté, SP, from March to November 2020. Methods: Cross-sectional study with secondary data obtained from the Epidemiological Surveillance System about confirmed cases in city residents and from medical records of patients who were treated in hospitals in Taubaté, aged between 0 and 19 years. Chi-square and Student’s t tests were used for comparisons. Results: 677 cases in the studied age range were reported during the study period, corresponding to 10.1% of cases reported in the municipality. The rapid antibody test was the most used to confirm infection, followed by RT-PCR and serology. Symptoms were described in 57.7% of the cases, mainly fever and cough. Diarrhea was associated with age below 4 years, while fever, cough, headache, odynophagia, ageusia, anosmia, myalgia, and dyspnea were associated with an age ranging from 10 to 19 years. In the study period, there were no deaths from COVID-19 of residents of the municipality in the age group from 0 to 19 years. Conclusions: The study was able to identify the proportion of involvement of COVID-19 in children and adolescents in the city, and the disease had a mild evolution. The main symptoms were fever and cough, but mainly diarrhea in younger children, and headache, odynophagia, anosmia, ageusia, and myalgia in adolescents.

RESUMO: Objetivo: Descrever os aspectos metodológicos e operacionais do projeto “Vigilância do câncer e seus fatores associados: registro de base populacional e hospitalar” (VIGICAN), em Mato Grosso (MT). Métodos: O VIGICAN desdobrou-se em dois projetos: um de extensão, que atualizou os dados dos Registros de Câncer de Base Populacional (RCBP) de Mato Grosso no período de 2008 a 2016; e um de pesquisa, que coletou dados primários por meio de entrevistas individuais e análise de prontuários de pessoas com diagnóstico de câncer, com 18 anos ou mais, atendidas em hospitais de referência para oncologia. Para analisar os fatores associados ao câncer, foram coletadas as seguintes variáveis: socioeconômicas e demográficas, suporte social, situação e comportamentos de saúde e exposição ambiental. Resultados: No período de 2008 a 2016, foram notificados nos RCBP Cuiabá e Interior, aproximadamente, 100 mil casos de câncer (incidentes e prevalentes). Após os procedimentos de validação, foram eleitos 50 mil casos incidentes. A pesquisa entrevistou 1.012 pacientes, sendo 38,2% residentes nos municípios de Cuiabá e Várzea Grande, 60,4% no interior do Estado e 1,4% em outros Estados. Os dados preliminares revelaram que a maioria era do sexo feminino (55,0%) e tinha menos de 60 anos (54,3%). Entre os entrevistados, 7,2% relataram fumar tabaco, 15,5% consumiam bebidas alcoólicas (15,5%) e 32,7% moravam próximo a lavouras. Conclusão: O desenvolvimento desses projetos permitiu a integração do ensino com os serviços de saúde e possibilitará o reconhecimento das especificidades e dos diferentes cenários de exposição ao câncer, bem como fatores associados a ele, no território mato-grossense.

ABSTRACT: Objective: To describe the methodological and operational aspects of the “Project for surveillance of cancer and its associated factors: population-based and hospital-based registry” (VIGICAN), in the state of Mato Grosso (MT), Brazil. Methods: VIGICAN was divided into two projects: a university extension one, which updated the data from the Population-based Cancer Registry (PBCR) of MT in the 2008-2016 period; and a research project, which collected primary data, through individual interviews and analysis of medical records of people with a diagnosis of cancer, aged 18 years or older, treated at reference hospitals for oncology. To analyze the factors associated with cancer, the following variables were collected: socioeconomic and demographic, social support, health status and behavior, and environmental exposure. Results: In the 2008-2016 period, approximately one hundred thousand cases of cancer (incident and prevalent) were reported in the PBCR Cuiabá and PBCR Interior. After validation procedures, 50 thousand incident cases were elected. The survey interviewed 1,012 patients, 38.2% living in the municipalities of Cuiabá and Várzea Grande, 60.4% in small cities of the state, and 1.4% in other states. Preliminary data showed that the majority were women (55.0%) and younger than 60 years of age (54.3%). Among the interviewees, 7.2% reported smoking tobacco, 15.5% consumed alcoholic beverages (15.5%), and 32.7% lived nearby crops. Conclusion: The development of these projects allowed the integration of education with health services and will enable the recognition of specificities and different exposure scenarios and factors associated with cancer in the Mato Grosso territory.