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This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic band at 407 nm in the UV-Vis spectrum. The AgNPs presented a spherical shape and size of 9.7 ± 0.3 nm. The nanoparticles were stable over a month, indicating that E. grandis’ extract is suitable for their preparation and stabilization. The X-ray analysis showed that the crystallinity of AgNPs corresponded to the centered face phase of silver. The antibacterial and leishmanicidal activities of AgNPs were evaluated. The AgNPs presented antibacterial activity on the Gram-negative bacteria Escherichia coli at 53.9 µg mL-1. The leishmanicidal activity evaluation against promastigote forms of Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis showed that the biological response is dependent on the volume of AgNP suspension. It was demonstrated that L. infantum was more sensitive to the nanoparticle’s treatment than L. amazonensis and L. braziliensis. The treatment of L infantum promastigotes with 150 µL of AgNP suspension reduced parasite growth by 67.9%, a result which was similar to the treatment with 1 (66.7%) or 2 µL (70.6%) of amphotericin B used as a positive control.

https://doi.org/10.21577/0103-5053.20220126

A completeness indicator of gestational and congenital syphilis information in Brazil
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Oliveira, Guilherme Lopes de

; Ferreira, Andrêa JF

; Santana, José Guilherme

; Lana, Raquel Martins

; Cardoso, Andrey Moreira

; Teles, Carlos

; Fiaccone, Rosemeire L.

; Aquino, Rosana

; Soares, Maria Auxiliadora Santos

; Paixao, Enny S.

; Santos, Idália Oliveira

; Salvi, Leonardo

; Barreto, Maurício L.

; Ichihara, Maria Yury

Revista de Saúde Pública

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2023, Volume 57 elocation 42

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE To evaluate the quality of information on gestational syphilis (GS) and congenital syphilis (CS) on the Sistema de Informação de Agravos de Notificação (SINAN-Syphilis Brazil – Notifiable Diseases Information System) by compiling and validating completeness indicators between 2007 and 2018. METHODS Overall, care, and socioeconomic completeness scores were compiled based on selected variables, by using ad hoc weights assigned by experts. The completeness scores were analysed, considering the region and area of residence, the pregnant woman’s race/colour, and the year of case notification. Pearson’s correlation coefficients were used to validate the scores obtained by the weighted average method, compared with the values obtained by principal component analysis (PCA). RESULTS Most selected variables presented a good or excellent degree of completeness for GS and CS, except for clinical classification, pregnant woman’s level of education, partner’s treatment, and child’s race/colour, which were classified as poor or very poor. The overall (89.93% versus 89.69%) and socioeconomic (88.71% versus 88.24%) completeness scores for GS and CS, respectively, were classified as regular, whereas the care score (GS-90.88%, and CS-90.72%) was good, despite improvements over time. Differences in the overall, care and socioeconomic completeness scores according to region, area of residence, and ethnic-racial groups were reported for syphilis notifications. The completeness scores estimated by the weighted average method and PCA showed a strong linear correlation (> 0.90). CONCLUSION The completeness of GS and CS notifications has been improving in recent years, highlighting the variables that form the care score, compared with the socioeconomic scores, despite differences between regions, area of residence, and ethnic-racial groups. The weighted average was a viable methodological alternative easily operationalised to estimate data completeness scores, allowing routine monitoring of the completeness of gestational and congenital syphilis records.

https://doi.org/10.11606/s1518-8787.2023057004789

Sporothrix brasiliensis infecting cats in northeastern Brazil: New emerging areas in Paraíba state
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Angelo, Débora Ferreira dos Santos

; Rabello, Vanessa Brito de Souza

; Maciel, Maria Adrielle Soares

; Atanázio, Sheilla Suellenn de Lemos Araújo

; Costa, Maria Clara Lima da

; Silva, Suely Ruth

; Almeida-Paes, Rodrigo

; Bernardes-Engemann, Andréa Reis

; Zancopé-Oliveira, Rosely Maria

; Clementino, Inácio José

Ciência Rural

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2023, Volume 53 N. 10 elocation e20220351

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT: Sporotrichosis is a subcutaneous mycosis caused by fungus of the Sporothrix complex, and in Brazil the main species reported is Sporothrix brasiliensis, of which the diseased cat is the transmitter. Although, its occurrence has increased in the state of Paraíba, Brazil, since 2016, data on the disease in this state are limited. Therefore, this research aimed to identify molecularly isolates of Sporothrix spp. from domestic cats from cities in Paraíba, and in this way to expand the understanding of the disease in the state. Thirty-nine samples were analyzed, obtained from skin lesions of domestic felines, from the following cities in Paraíba: João Pessoa, Pilões, Patos, Areia, Bananeiras and Guarabira. Cytological analysis was performed to screen the samples, followed by fungal culture, and the molecular characterization of the isolates was performed, using the species-specific Polymerase Chain Reaction (PCR) or partial sequencing of the calmodulin gene. All isolates were identified as S. brasiliensis. The sequencing showed 100% similarity to the S. brasiliensis CBS 120339 strain. In view of this, it is concluded that in the study areas the species involved in cases of feline sporotrichosis is S. brasiliensis, its presence in Paraíba demonstrated the spread of the agent in regions distant from the epicenters in Brazil, alerting to the possible occurrence of zoonotic outbreaks similar to those found in the South and Southeast regions of the country. In addition, it highlights the emerging role of felines in the transmission of sporotrichosis in new endemic areas of Brazil.

RESUMO: A esporotricose é uma micose subcutânea causada por fungos do complexo Sporothrix, e no Brasil a principal espécie relatada é Sporothrix brasiliensis da qual o transmissor é o gato doente. Embora sua ocorrência tenha aumentado no estado da Paraíba, Brasil, desde 2016, os dados sobre a doença neste estado são limitados. Diante disso, esta pesquisa teve por objetivo identificar, molecularmente, isolados de Sporothrix spp. procedentes de felinos domésticos de cidades da Paraíba, e dessa maneira expandir a compreensão da enfermidade no estado. Foram analisadas 39 amostras, obtidas de lesões cutâneas de felinos domésticos, oriundos das seguintes cidades paraibanas: João Pessoa, Pilões, Patos, Areia, Bananeiras e Guarabira. Realizou-se análise citológica, para triagem das amostras, a seguir cultura fúngica, e posteriormente a caracterização molecular dos isolados, utilizando a Reação em Cadeia da Polimerase (PCR), espécie-específica ou sequenciamento parcial do gene calmodulina. Todos os isolados foram identificados molecularmente como S. brasiliensis. O sequenciamento demonstrou 100% de similaridade com a cepa S. brasiliensis CBS 120339. Contudo, conclui-se que nas áreas do estudo a espécie envolvida em casos de esporotricose felina é S. brasiliensis, sua presença na Paraíba demonstra a disseminação do agente em regiões distantes dos epicentros no Brasil, alertando para a possível ocorrência de surtos zoonóticos, semelhantes aos encontrados nas regiões Sul e Sudeste do país. Além disso, destaca o papel emergente dos felinos na transmissão da esporotricose em novas áreas endêmicas do Brasil.

https://doi.org/10.1590/0103-8478cr20220351

A completeness indicator of gestational and congenital syphilis information in Brazil
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Oliveira, Guilherme Lopes de

; Ferreira, Andrêa JF

; Santana, José Guilherme

; Lana, Raquel Martins

; Cardoso, Andrey Moreira

; Teles, Carlos

; Fiaccone, Rosemeire L.

; Aquino, Rosana

; Soares, Maria Auxiliadora Santos

; Paixao, Enny S.

; Santos, Idália Oliveira

; Salvi, Leonardo

; Barreto, Maurício L.

; Ichihara, Maria Yury

Revista de Saúde Pública

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2023, Volume 57 elocation 42

Abstract: En | Text: En | PDF: En

https://doi.org/10.11606/s1518-8787.2023057004789

Different evaluation methods of Canchim cattle temperament
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Marcondes, Cintia Righetti

; Souza, Vanessa Aparecida Feijó de

; Bugner, Ana Luisa Paçó

; Oliveira, Fábio da Roza

; Maffei, Walsiara Estanislau

; Ribeiro, Andrea Roberto Bueno

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03350

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The objective of this work was to evaluate the temperament of Canchim calves using different methods, to compare these methods, and to determine the most suitable for commercial use. The temperament of 1,831 calves was evaluated at 15 days after weaning by visually analyzing movement, tension, breathing, vocalizing, and kicking. Measurements were taken at 10 and 20 s after the calf entered the scale. The reactivity score was determined electronically, and flight speed was measured after the calf left the scale. The results of the principal component analysis showed that the first component explained 40.27% of total variation. Positive correlations were found for tension at 10 and 20 s, movement at 10 and 20 s, and reactivity score, with correlation coefficients ranging from 0.60 to 0.88. Temperament and reactivity scores presented moderate correlations of 0.25 and 0.35, respectively, with flight speed. However, kicking had no correlation with any variable. No differences were observed for reactivity measured at 10 or 20 s. The visual evaluations of movement and tension or of reactivity through an electronic device can be used for temperament evaluation of Canchim calves.

Resumo O objetivo deste trabalho foi avaliar o temperamento de bezerros da raça Canchim por meio de diferentes métodos, comparar estes métodos e determinar o mais adequado para uso comercial. O temperamento de 1.831 bezerros foi avaliado 15 dias após a desmama, tendo-se analisado visualmente deslocamento, tensão, respiração, vocalização e coice. As medidas foram feitas aos 10 e 20 s após o bezerro entrar na balança. A reatividade foi determinada eletronicamente, e a velocidade de saída foi medida após o bezerro sair da balança. O resultado da análise de componentes principais indicou que o primeiro componente explicou 40,27% da variação total. Foram verificadas correlações positivas para tensão aos 10 e 20 s, deslocamento aos 10 e 20 s, e reatividade, com coeficientes de correlação de 0,60 a 0,88. Os escores de temperamento e reatividade apresentaram correlação moderada de 0,25 e 0,35, respectivamente, com velocidade de saída. No entanto, coice não se correlacionou com nenhuma variável. Não foi observada nenhuma diferença para reatividade medida aos 10 ou 20 s. As avaliações visuais de deslocamento e tensão ou da reatividade por dispositivo eletrônico podem ser utilizadas na avaliação de temperamento de bezerros Canchim.

https://doi.org/10.1590/s1678-3921.pab2023.v58.03350

Interaction of Lead and Calcium with Biochar Produced from Cassava Waste: Perspectives for Agricultural and Environmental Application
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Silva, Ricardo R. da

; Oliveira, Luciana C. de

; Gabriel, Gabriele V. M.

; Soletti, João I.

; Bispo, Mozart D.

; Paulino, Sivaldo S.

; Meneghetti, Simoni M. P.

; Assis, Geovânia C. de

; Fernandes, Andrea P.

; Botero, Wander G.

Journal of the Brazilian Chemical Society

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dec 2022, Volume 33 N. 12 Pages 1402 - 1413

Abstract: En | Text: En | PDF: En

Biochar from slow pyrolysis under controlled conditions is favorable in the transformation of waste into materials that serve as soil conditioners, and/or environmental remediation. Thus, this work aimed to produce and characterize biochar from cassava waste under different temperature conditions and evaluate interactions with Ca2+ and Pb2+ for agricultural and environmental applications. To investigate the efficiency of the interaction of biochar with nutrients (Ca) and contaminants (Pb), the influence of pH and contact time were evaluated. There was an increase in pH, pHzpc (zero point charge), and condensed aromatic structures in BC, due to the increase in pyrolysis temperature. Also, biochar demonstrated a Pb2+ adsorbed amount of 2.03 to 2.37 mg g-1 and a Ca2+ release capacity of 0.655 to 0.765 mg g-1. In this way, biochar produced from residues of cassava waste can be a viable strategy to enhance agricultural production and reduce environmental contaminants.

https://doi.org/10.21577/0103-5053.20220076

[SciELO Preprints] - Chemical prospecting and antioxidant, anticholinesterase and antifungal activity of ethanol extracts from Senna Mill. species. (Fabaceae)
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Neves, Andréa Maria Morais, Selene Maia de Santos, Hélcio Silva dos Ferreira, Marcílio Matos Cruz, Ricardo Carneiro Vera Souza, Elnatan Bezerra de Andrade, Lúcia Betânia da Silva Fontenelle, Raquel Oliveira dos Santos

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Publication date: 2022-01-10

Abstract: En Pt

The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.

O objetivo deste trabalho foi avaliar o perfil químico, teor de fenóis totais e as atividades antioxidante, antiacetilcolinesterásica e antifúngica dos extratos etanólicos das folhas (EEF) e do caule (EEC) de cinco espécies de Senna, bem como avaliar a correlação entre o conteúdo de fenóis totais com a atividade sequestradora do radical livre DPPH e com a inibição da enzima acetilcolinesterase AChEI. No teste fitoquímico, evidenciou-se a presença de metabólitos secundários em todos os extratos. Os EEF e EEC de Senna trachypus, destacaram-se por apresentar os maiores valores de fenóis totais. Os EEF e EEC de S. trachypus mostraram a melhor ação sobre a enzima acetilcolinesterase. Todas as espécies apresentaram atividade antioxidante, em especial o EEF de S. trachypus. Foi observado correlação forte para as variáveis fenóis totais e atividade antioxidante (rnbsp;=nbsp;-0,71), muito forte para fenóis totais e antiacetilcolinesterase (rnbsp;=nbsp;-0,84) e atividade moderada para atividade antioxidante e antiacetilcolinesterase (0,43). Apenas os extratos de S. trachypus apresentaram atividade contra todos os dermatófitos, quando comparado às demais espécies. A espécie S. trachypus foi considerada a planta mais promissora para estudos subsequentes, a fim de encontrar compostos com ações farmacológicas.

https://doi.org/10.1590/2236-8906-111/2020

Biomechanical and microbiological analysis of embalmed cats – acute effect of conservation
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QUEIROZ, ANDRÉA B.P.S.

; RODRIGUES, ALESSANDRA

; CARDOZO, MARITA V.

; COSTA, NATÁLIA T.B.

; SOARES, LAURA G.

; FECHIS, ALISSON D.S.

; OLIVEIRA, FABRÍCIO S.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 N. 1 elocation e20201583

Abstract: En | Text: En | PDF: En

Abstract Animals corpses in teaching and research institutions could be sources of infection for students and teachers when applied for dissection and surgical practice. This research aimed to evaluate cats’ corpses’ conservation using a new anatomic technique and vacuum package for seven days, aiming surgical practicing. A 150 mL/kg of alcohol with 5% glycerin and 120 mL/kg of a 20% sodium chloride, 1% nitrite, and 1% sodium nitrate solution was injected on corpses sealed in vacuum packages and put on 0 to 4°C. Skin and jejunum were collected on day 0 (fresh samples/control), and traction analysis was performed for seven consecutive days. On the last day, the liquid in the plastic bags was microbiologically analyzed. There was no statistical difference between control and conservation moments (D1 and D2) in maximal rupture force of the skin, and jejunum was similar to control in D2, D4, and D6. The microbial population did not exceed 6.0x104CFU/mL in total aerobics and 4.8x104CFU/mL in total anaerobes. Biomechanics was not significantly affected, and the microbiological count was low during conservation, demonstrating the possible effectiveness of this anatomical technique for surgery training.

https://doi.org/10.1590/0001-3765202120201583

Prospecção química, atividade antioxidante, anticolinesterásica e antifúngica de extratos etanólicos de espécies de Senna Mill. (Fabaceae)
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Neves, Andréa Maria

; Morais, Selene Maia de

; Santos, Hélcio Silva dos

; Ferreira, Marcílio Matos

; Cruz, Ricardo Carneiro Vera

; Souza, Elnatan Bezerra de

; Andrade, Lúcia Betânia da Silva

; Fontenelle, Raquel Oliveira dos Santos

Hoehnea

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2022, Volume 49 elocation e1112020

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo deste trabalho foi avaliar o perfil químico, teor de fenóis totais e as atividades antioxidante, antiacetilcolinesterásica e antifúngica dos extratos etanólicos das folhas (EEF) e do caule (EEC) de cinco espécies de Senna, bem como avaliar a correlação entre o conteúdo de fenóis totais com a atividade sequestradora do radical livre DPPH e com a inibição da enzima acetilcolinesterase AChEI. No teste fitoquímico, evidenciou-se a presença de metabólitos secundários em todos os extratos. Os EEF e EEC de Senna trachypus, destacaram-se por apresentar os maiores valores de fenóis totais. Os EEF e EEC de S. trachypus mostraram a melhor ação sobre a enzima acetilcolinesterase. Todas as espécies apresentaram atividade antioxidante, em especial o EEF de S. trachypus. Foi observado correlação forte para as variáveis fenóis totais e atividade antioxidante (r = -0,71), muito forte para fenóis totais e antiacetilcolinesterase (r = -0,84) e atividade moderada para atividade antioxidante e antiacetilcolinesterase (0,43). Apenas os extratos de S. trachypus apresentaram atividade contra todos os dermatófitos, quando comparado às demais espécies. A espécie S. trachypus foi considerada a planta mais promissora para estudos subsequentes, a fim de encontrar compostos com ações farmacológicas.

ABSTRACT The objective of this work was to evaluate the chemical profile, total phenol content and the antioxidant, antiacetylcholinesterase and antifungal activities of ethanol extracts from leaves (EEF) and stem (EEC) of five species of Senna, as well as to evaluate the correlation between the content of total phenols with the DPPH free radical scavenging activity and with the inhibition of the acetylcholinesterase AChEI enzyme. The phytochemical test showed the presence of secondary metabolites in all extracts. The EEF and EEC of Senna trachypus, stood out for presenting the highest values of total phenols. S. trachypus EEF and EEC showed the best action on the acetylcholinesterase enzyme. All species showed antioxidant activity, especially the EEF from S. trachypus. A strong correlation was observed for the variables total phenols and antioxidant activity (r = -0.71), very strong for total phenols and anti-acetylcholinesterase (r = -0.84) and moderate activity for antioxidant and anti-acetylcholinesterase activity (r = 0.43). Only S. trachypus extracts showed activity against all dermatophytes, when compared to the other species. The species S. trachypus was considered the most promising plant for further studies, in order to find compounds with pharmacological actions.

https://doi.org/10.1590/2236-8906-111/2020

10.

Uso de antibacterianos em gestantes antes e após regulamentação no Brasil: coortes de nascimentos de Pelotas, Rio Grande do Sul, de 2004 e 2015
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Guimarães, Fernando Silva

; Cata-Preta, Bianca Oliveira

; Barros, Aluísio J. D.

; Matijasevich, Alicia

; Santos, Iná S.

; Silveira, Mariângela Freitas

; Silveira, Marysabel Pinto Telis

; Bertoldi, Andréa Dâmaso

Cadernos de Saúde Pública

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2022, Volume 38 N. 7 elocation e00168021

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

A utilização indiscriminada de antibacterianos no período gestacional pode aumentar a resistência antimicrobiana e colocar em risco a saúde da gestante e da criança. Atualmente, está em vigência no Brasil a Resolução da Diretoria Colegiada nº 20/2011, que controla a prescrição e fornecimento de antibacterianos. O objetivo deste estudo foi comparar o uso de antibacterianos pelas gestantes participantes das coortes de nascimentos de Pelotas, Rio Grande do Sul, Brasil, de 2004 e 2015, considerando a regulamentação implementada entre as duas coortes. Foram utilizados dados coletados no período perinatal dos dois estudos. O desfecho principal foi o uso de antibacterianos na gestação. As prevalências de uso foram descritas a partir de variáveis independentes e diferenças em pontos percentuais (p.p.) entre as duas coortes. A prevalência do uso de antibacterianos foi de 41,9% (IC95%: 40,4; 43,3) em 2004 e 39,2% (IC95%: 37,7; 40,6) em 2015. Considerando-se as gestantes que relataram ter infecção durante a gestação, observou-se maior redução de uso em 2015, quando comparado a 2004, nas gestantes mais pobres (-15,4p.p., IC95%: 9,59; 21,20) e naquelas que foram a menos consultas (-17,1p.p., IC95%: 2,81; 31,36). Houve redução na proporção de antibacterianos usados, considerando o total de medicamentos de 20,6% (IC95%: 19,9; 21,4) em 2004 para 12,6% (IC95%: 12,1; 13,1) em 2015. As reduções encontradas, tanto nas prevalências de uso quanto na proporção dos antibacterianos sobre o total de medicamentos utilizados, podem ser reflexo da política de regulamentação implementada em 2011.

Indiscriminate use of anti-bacterial agents during pregnancy can increase antimicrobial resistance and endanger both the mother’s and the children’s health. Currently, Brazil has the Collegiate Directive Resolution n. 20/2011, which controls prescription and dispensation of anti-bacterial agents. Given this scenario, this study compared the use of anti-bacterial agents by pregnant women participating in the 2004 and 2015 Pelotas (Brazil) birth cohorts, in Rio Grande do Sul, Brazil, considering the regulation issued between the two cohorts. Data were collected in the perinatal period of the two studies. The main outcome was the use of anti-bacterial agents during pregnancy. Prevalence scans were described based on independent variables and differences in percentage points (p.p.) between the two cohorts. The prevalence of anti-bacterial use was 41.9% (95%CI: 40.4; 43.3) in 2004 and 39.2% (95%CI: 37.7; 40.6) in 2015. Considering the pregnant women who reported having infection during pregnancy, a greater reduction in use was observed in 2015, when compared to 2004, in poor women (-15.4p.p., 95%CI: 9.59; 21.20) and in those who had less consultations (-17.1p.p., 95%CI: 2.81; 31.36). Considering total medications, the proportion of anti-bacterial used dropped from 20.6% (95%CI: 19.9; 21.4) in 2004 to 12.6% (95%CI: 12.1; 13.1) in 2015. The reductions found in both the prevalence of use and the proportion of anti-bacterial agents over total medications used may be a reflection of the regulatory policy implemented in 2011.

El uso indiscriminado de antibacterianos durante el embarazo puede aumentar la resistencia a los antimicrobianos y poner en riesgo la salud de la gestante y del niño. Actualmente, está vigente en Brasil la Resolución de la Dirección Colegiada nº 20/2011, que controla la prescripción y dispensación de antibacterianos. El objetivo de este estudio fue comparar el uso de antibacterianos por gestantes participantes de las cohortes de nacimientos de Pelotas, Rio Grande do Sul, Brasil, del 2004 y del 2015, considerando la regulación implementada entre las dos cohortes. Se utilizaron los datos recopilados en el período perinatal de los dos estudios. El resultado principal fue el uso de antibacterianos durante el embarazo. Las prevalencias de uso se describieron con base en las variables independientes y diferencias en puntos porcentuales (p.p.) entre las dos cohortes. La prevalencia de uso de antibacterianos fue del 41,9% (IC95%: 40,4; 43,3) en el 2004 y del 39,2% (IC95%: 37,7; 40,6) en el 2015. Teniendo en cuenta que las gestantes que reportaron haber tenido infección durante el embarazo, hubo una mayor reducción de uso en el 2015, en comparación con el 2004, en las gestantes más pobres (-15,4p.p., IC95%: 9,59; 21,20) y en las que consultaron menos (-17,1p.p., IC95% 2,81;31,36). Hubo una reducción en la proporción de antibacterianos usados, considerando la cantidad total de medicamentos del 20,6% (IC95%: 19,9; 21,4) en el 2004 al 12,6% (IC95%: 12,1; 13,1) en el 2015. Las reducciones encontradas, tanto en las prevalencias de uso como en la proporción de antibacterianos sobre la cantidad total de medicamentos utilizados, pueden ser reflejo de la política regulatoria implementada en el 2011.

https://doi.org/10.1590/0102-311xpt168021

11.

Uso de antibacterianos em gestantes antes e após regulamentação no Brasil: coortes de nascimentos de Pelotas, Rio Grande do Sul, de 2004 e 2015
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Guimarães, Fernando Silva

; Cata-Preta, Bianca Oliveira

; Barros, Aluísio J. D.

; Matijasevich, Alicia

; Santos, Iná S.

; Silveira, Mariângela Freitas

; Silveira, Marysabel Pinto Telis

; Bertoldi, Andréa Dâmaso

Cadernos de Saúde Pública

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2022, Volume 38 N. 7 elocation e00168021

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xpt168021

12.

Production time and container size for Simarouba amara Aubl. seedlings
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Santos, Jiovana Pereira Amorim

; Souza, Manuela Oliveira de

; Souza, Josival Santos

; Silva, Rodrigo Ramos da

; Mendonça, Andrea Vita Reis

Floresta e Ambiente

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2022, Volume 29 N. 3 elocation e20220030

Abstract: En | Text: En | PDF: En

Abstract This study aims to determine the effect of nursery production time and container size on the quality standards of production of Simarouba amara seedlings based on nursery and field performance. The work was conducted in two phases: evaluation of nursery growth and field performance. A completely randomized design was used in both phases. Three container sizes (55, 180 and 280cm³) and four nursery production times (105, 125, 135 and 145 days) were tested. Height, collar diameter and survival were evaluated. S. amara seedlings can be produced in a 180 cm³ container with a maximum nursery production time of 125 days. The quality standard for seedlings corresponds to collar diameter ≥ 4.2 and height ≥ 9.1 cm.

https://doi.org/10.1590/2179-8087-floram-2022-0030

13.

Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review
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Ichihara, Maria Yury

; Ferreira, Andrêa J.F.

; Teixeira, Camila S. S.

; Alves, Flávia Jôse O.

; Rocha, Aline Santos

; Diógenes, Victor Hugo Dias

; Ramos, Dandara Oliveira

; Pinto Júnior, Elzo Pereira

; Flores-Ortiz, Renzo

; Rameh, Leila

; Costa, Lilia Carolina C. da

; Gonzaga, Marcos Roberto

; Lima, Everton E. C.

; Dundas, Ruth

; Leyland, Alastair

; Barreto, Maurício L.

Revista de Saúde Pública

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2022, Volume 56 elocation 85

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE Summarize the literature on the relationship between composite socioeconomic indicators and mortality in different geographical areas of Brazil. METHODS This scoping review included articles published between January 1, 2000, and August 31, 2020, retrieved by means of a bibliographic search carried out in the Medline, Scopus, Web of Science, and Lilacs databases. Studies reporting on the association between composite socioeconomic indicators and all-cause, or specific cause of death in any age group in different geographical areas were selected. The review summarized the measures constructed, their associations with the outcomes, and potential study limitations. RESULTS Of the 77 full texts that met the inclusion criteria, the study reviewed 24. The area level of composite socioeconomic indicators analyzed comprised municipalities (n = 6), districts (n = 5), census tracts (n = 4), state (n = 2), country (n = 2), and other areas (n = 5). Six studies used composite socioeconomic indicators such as the Human Development Index, Gross Domestic Product, and the Gini Index; the remaining 18 papers created their own socioeconomic measures based on sociodemographic and health indicators. Socioeconomic status was inversely associated with higher rates of all-cause mortality, external cause mortality, suicide, homicide, fetal and infant mortality, respiratory and circulatory diseases, stroke, infectious and parasitic diseases, malnutrition, gastroenteritis, and oropharyngeal cancer. Higher mortality rates due to colorectal cancer, leukemia, a general group of neoplasms, traffic accident, and suicide, in turn, were observed in less deprived areas and/or those with more significant socioeconomic development. Underreporting of death and differences in mortality coverage in Brazilian areas were cited as the main limitation. CONCLUSIONS Studies analyzed mortality inequalities in different geographical areas by means of composite socioeconomic indicators, showing that the association directions vary according to the mortality outcome. But studies on all-cause mortality and at the census tract level remain scarce. The results may guide the development of new composite socioeconomic indicators for use in mortality inequality analysis.

https://doi.org/10.11606/s1518-8787.2022056004178

14.

Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review
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Ichihara, Maria Yury

; Ferreira, Andrêa J.F.

; Teixeira, Camila S. S.

; Alves, Flávia Jôse O.

; Rocha, Aline Santos

; Diógenes, Victor Hugo Dias

; Ramos, Dandara Oliveira

; Pinto Júnior, Elzo Pereira

; Flores-Ortiz, Renzo

; Rameh, Leila

; Costa, Lilia Carolina C. da

; Gonzaga, Marcos Roberto

; Lima, Everton E. C.

; Dundas, Ruth

; Leyland, Alastair

; Barreto, Maurício L.

Revista de Saúde Pública

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2022, Volume 56 elocation 85

Abstract: En | Text: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056004178

15.

Clinical characteristics and evolution of hematological patients and COVID-19 in Argentina: a report from the Argentine Society of Hematology
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Basquiera, Ana L.

; García, Mercedes J

; Martinez Rolón, Juliana

; Olmedo, Julieta

; Laviano, Julia

; Burgos, Rubén

; Caeiro, Gastón

; Remaggi, Guillermina

; Raña, Pablo

; Paoletti, Mariano

; González, Carlos M.

; Fernández, Isolda

; Pavlovsky, Astrid

; Perusini, Maria A.

; Rodriguez, Andrea

; Guanchiale, Luciana

; Carvani, Analia

; Mandrile, Laura

; Figueroa, Flavia

; Vicente Reparaz, Ángeles

; Fragapane Mathus, Patricia N.

; Garate, Gonzalo

; Fauque, María E.

; Kantor, Gustavo

; Cruset, Soledad

; Gonzalez Lorch, Jacqueline S.

; Szelagowski, Milagros

; Giarini, María P.

; Oliveira, Natalia

; García, María C.

; Ventriglia, María V.

; Pereyra, Patricio H.

; Gutierrez, Daniel R.

; Kusminsky, Gustavo

; Troccoli, Josefina

; Freitas, María J.

; Cranco, Santiago

; Del V.Sanchez, Natalia

; Rey, Irene

; Funes, María E.

; Jarchum, Sol

; Freue, Julian

; Miroli, Augusto

; Guerrero, Osvaldo

; López Ares, Lisa

; Campestri, Reinaldo

; Bove, Victor

; Salinas, Graciela N.

; Cabrejo, María

; Milone, Jorge H.

; Zabaljauregui, Soledad

; Gotta, Daniel

; Dupont, Juan Carlos

; Stemmelin, German

Medicina (Buenos Aires)

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aug 2021, Volume 81 N. 4 Pages 536 - 545

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Individuals with malignancies and COVID-19 have a lower survival compared with the general population. However, the information about the impact of COVID-19 on the whole hematological population is scarce. We aimed to describe the 30th day overall survival (OS) after COVID-19 infection in pa tients with a hematological disease in Argentina. A completely anonymous survey from the Argentine Society of Hematology was delivered to all the hematologists in Argentina; it started in April 2020. A cut-off to analyze the data was performed in December 2020 and, finally, 419 patients were reported and suitable for the analysis (average age: 58 years, 90% with malignant diseases). After the COVID-19 diagnosis, the 30-day OS for the whole population was 80.2%. From the entire group (419), 101 (24.1%) individuals required intensive care unit admission, where the 30-day OS was 46.6%. Among allogeneic stem cell transplant recipients, the 30-day OS was 70.3%. Factors associated with a low OS were two or more comorbidities, an active hematological disease and history of chemotherapy. In individuals with the three factors, the 30-day OS was 49.6% while the 30-day OS in those without those factors was 100%. Patients with hematological diseases have a higher mortality than the general population. This group represents a challenge and requires careful decision-making of the treatment in order not to compromise the chances of cure.

Resumen El presente estudio tuvo por objetivo primario conocer la mortalidad de pacientes con enfermedad hematológica que presentaron infección por COVID-19 en Argentina. Para ello se difundió una encuesta desde la Sociedad Argentina de Hematología (SAH) entre los hematológos para informar sobre los pacientes con enfermedades hematológicas y diagnóstico de infección por SARS- CoV-2, entre el 19/4/2020, y el 7/12/2020. Se incluyeron individuos de todas las edades con diagnóstico de enfermedad hematológica benigna o maligna e infección por SARS-CoV-2 confirmada por técnica de RT-PCR. Se analizaron 419 pacientes (mediana 58 años; 90% enfermedades malignas). La supervivencia al día 30 fue de 80.2%. La supervivencia fue menor en aquellos que requirieron internación (74.2%), cuidados intensivos (46.6%) y asistencia respiratoria mecánica (36.8%). Entre los trasplantados alogénicos la supervivencia fue 70.3%. Los factores vinculados a la supervivencia global fueron las comorbilidades, el estado de la enfermedad al momento de la infección y el antecedente de quimioterapia. Se pudo establecer un score en el que aquellos que tuvieron un puntaje de 4 alcanzaron una supervivencia del 49.6% al día 30, mientras que la de los pacientes con score 0 fue del 100% a 30 días. En comparación con la población general, los pacientes con enfermedades hematológicas presentan una mayor mortalidad vinculada al COVID-19, motivo por el cual es primordial definir pautas destinadas a disminuir la exposición de los mismos sin comprometer las posibilidades de beneficiarse del tratamiento de la enfermedad de base.

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