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1.
[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio
Simões, Marcus V.
Correia, Edileide de Barros
Marcondes-Braga, Fabiana G.
Coelho-Filho, Otavio Rizzi
Mesquita, Cláudio Tinoco
Mathias-Junior, Wilson
Rochitte, Carlos Eduardo
Ramires, Felix José Alvarez
Alves, Silvia Marinho Martins
Montera, Marcelo Westerlund
Lopes, Renato Delascio
Oliveira-Junior, Mucio Tavares
Scolari, Fernando L.
Avila, Walkiria Samuel
Canesin, Manoel Fernandes
Bacal, Fernando
Bocchi, Edimar Alcides
Moura, Lídia Ana Zytynski
Saad, Eduardo Benchimol
Scanavacca, Mauricio I.
Valdigem, Bruno Pereira
Cano , Manuel Nicolas
Abizaid , Alexandre
Ribeiro, Henrique Barbosa
Lemos-Neto, Pedro Alves
Ribeiro, Gustavo Calado de Aguiar
Jatene, Fabio Biscegli
Dias, Ricardo Ribeiro
Beck-da-Silva, Luis
Rohde, Luis Eduardo P.
Bittencourt, Marcelo Imbroinise
Pereira, Alexandre
Krieger, José Eduardo
Villacorta, Humberto
Martins, Wolney de Andrade
Figueiredo-Neto, José Albuquerque de
Cardoso , Juliano Novaes
Pastore, Carlos Alberto
Jatene, Ieda Biscegli
Tanaka, Ana Cristina Sayuri
Hotta, Viviane Tiemi
Romano, Minna Moreira Dias
Albuquerque, Denilson Campos de
Mourilhe-Rocha, Ricardo
Hajjar, Ludhmila Abrahão
Brito, Fabio Sandoli de
Caramelli , Bruno
Calderaro, Daniela
Farsky, Pedro Silvio
Colafranceschi , Alexandre Siciliano
Pinto, Ibraim Masciarelli
Vieira , Marcelo Luiz Campos
Danzmann, Luiz Claudio
Barberato , Silvio Henrique
Mady, Charles
Martinelli-Filho, Martino
Torbey , Ana Flavia Malheiros
Schwartzmann, Pedro Vellosa
Macedo, Ariane Vieira Scarlatelli
Ferreira , Silvia Moreira Ayub
Schmidt, Andre
Melo , Marcelo Dantas Tavares de
Lima-Filho, Moysés Oliveira
Sposito, Andrei C.
Brito, Flavio de Souza
Biolo, Andreia
Madrini-Junior, Vagner
Rizk, Stéphanie Itala
Mesquita, Evandro Tinoco
A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE. Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).
La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).
Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.
2.
The potential impact of PM2.5 on the covid-19 crisis in the Brazilian Amazon region
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Gonçalves, Karen dos Santos
; Cirino, Glauber G.
; Costa, Marcelo Oliveira da
; Couto, Lucas de Oliveira do
; Tortelote, Giovane G.
; Hacon, Sandra de Souza
.
ABSTRACT OBJECTIVE This study aims to assess covid-19 morbidity, mortality, and severity from 2020 to 2021 in five Brazilian Amazon states with the highest records of wildfires. METHODS A distributed lag non-linear model was applied to estimate the potential exposure risk association with particulate matter smaller than 2.5-µm in diameter (PM2.5). Daily mean temperature, relative humidity, percentual of community mobility, number of hospital beds, days of the week, and holidays were considered in the final models for controlling the confounding factors. RESULTS The states of Para, Mato Grosso, and Amazonas have reported the highest values of overall cases, deaths, and severe cases of covid-19. The worrying growth in the percentual rates in 2020/2021 for the incidence, severity, and mortality were highlighted in Rondônia and Mato Grosso. The growth in 2020/2021 in the estimations of PM2.5 concentrations was higher in Mato Grosso, with an increase of 24.4%, followed by Rondônia (14.9%). CONCLUSION This study establishes an association between wildfire-generated PM2.5 and increasing covid-19 incidence, mortality, and severity within the studied area. The findings showed that the risk of covid-19 morbidity and mortality is nearly two times higher among individuals exposed to high concentrations of PM2.5. The attributable fraction to PM2.5 in the studied area represents an important role in the risk associated with covid-19 in the Brazilian Amazon region.
3.
Effects of corn straw on meat characteristics of lambs in the Brazilian semi-arid region
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OLIVEIRA, ANA B. DE
; PAULA, TALITA A. DE
; SOUSA, WANDRICK HAUSS DE
; FERREIRA, MARCELO A.
; CARTAXO, FELIPE Q.
; CEZAR, MARCÍLIO F.
; NEVES, MARIA LUCIANA M. WANDERLEY
; BARRETO, LÍGIA MARIA G.
; OLIVEIRA, FLÁVIO G. DE
; GOMES, RAYANE N.
; VÉRAS, ANTONIA SHERLÂNEA C.
.
Abstract The present study aimed to evaluate the influence of increasing levels of corn straw replacement of sorghum silage on average daily gain, loin eye area, subcutaneous fat thickness, weight of commercial cuts, leg tissue composition, and physico-chemical characteristics of the meat from F1 Santa Inês × Dorper lambs maintained in a feedlot system. Treatments consisted of 0, 33, 66 and 100% corn straw replacement of sorghum silage. There were thirty-six 150-day-old male lambs. Corn straw replacement of sorghum silage in lamb feed reduced the average daily gain and weight of the ribs, besides promoting a quadratic influence on leg fat content. However, there was no influence on commercial carcass cuts, leg muscle index, leg tissue composition, and physico-chemical characteristics of the meat. Thus, corn straw can be used as alternative feedstuff for sheep rations to improve the production of high-quality sheep meat in semi-arid regions.
4.
Long-term Ecological Research: Chasing fashions or being prepared for fashion changes?
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BERGALLO, HELENA G.
; ROSA, CLARISSA
; OCHOA, ANA C.
; MANZATTO, ANGELO GILBERTO
; GUIMARAES, ARETHA F.
; BANHOS, AUREO
; CASTILHO, CAROLINA V.
; BARROS, CLAUDIA F.
; NORRIS, DARREN
; DRUCKER, DEBORA P.
; RODRIGUES, DOMINGOS J.
; BACCARO, FABRICIO B.
; LOURENÇO, IGOR H.
; ZUANON, JANSEN
; STEGMANN, LIS F.
; ANJOS, MARCELO R.
; SILVEIRA, MARCOS
; ARAÚJO, PATRICIA S.G.
; BOBROWIEC, PAULO E.D.
; FADINI, RODRIGO
; NECKEL-OLIVEIRA, SELVINO
; EMILIO, THAISE
; SANTORELLI JUNIOR, SERGIO
; MAGNUSSON, WILLIAM E.
.
Abstract Long-term-ecological-research (LTER) faces many challenges, including the difficulty of obtaining long-term funding, changes in research questions and sampling designs, keeping researchers collecting standardized data for many years, impediments to interactions with local people, and the difficulty of integrating the needs of local decision makers with “big science”. These issues result in a lack of universally accepted guidelines as to how research should be done and integrated among LTER sites. Here we discuss how the RAPELD (standardized field infrastructure system), can help deal with these issues as a complementary technique in LTER studies, allowing comparisons across landscapes and ecosystems and reducing sampling costs. RAPELD uses local surveys to understand broad spatial and temporal patterns while enhancing decision-making and training of researchers, local indigenous groups and traditional communities. Sampling of ecological data can be carried out by different researchers through standardized protocols, resulting in spatial data that can be used to answer temporal questions, and allow new questions to be investigated. Results can also be integrated into existing biodiversity networks. Integrated systems are the most efficient way to save resources, maximize results, and accumulate information that can be used in the face of the unknown unknowns upon which our future depends.
5.
First record of insect-plant interaction in Late Cretaceous fossils from Nelson Island (South Shetland Islands Archipelago), Antarctica
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SANTOS FILHO, EDILSON B. DOS
; BRUM, ARTHUR S.
; SOUZA, GEOVANE A. DE
; FIGUEIREDO, RODRIGO G.
; USMA, CRISTIAN D.
; RICETTI, JOÃO HENRIQUE Z.
; TREVISAN, CRISTINE
; LEPPE, MARCELO
; SAYÃO, JULIANA M.
; LIMA, FLAVIANA J.
; OLIVEIRA, GUSTAVO R.
; KELLNER, ALEXANDER W.A.
.
Anais da Academia Brasileira de Ciências
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Abstract Despite the enormous paleobotanical record on different islands of the Antarctic Peninsula, the evidence of insect activity associated with fossilized plants is scarce. Here we report the first evidence of insect-plant interaction from Cretaceous deposits, more precisely from a new locality at the Rip Point area, Nelson Island (Antarctic Peninsula). The macrofossil assemblage includes isolated Nothofagus sp. leaf impressions, a common component of the Antarctic paleoflora. Two hundred leaves were examined, of which 15 showed evidence of insect activity, displaying variations in size, shape, and preservation. Two types of interaction damage, galls and mines, were identified. A single specimen retained a circular scar recognized as galling scar, while meandering tracks were considered mines. These traces of herbivore insect activity, correspond to the oldest known record of this type of interaction of West Antarctica and the oldest record of insect-plant interaction in Nothofagus sp. reported so far.
6.
The potential impact of PM2.5 on the covid-19 crisis in the Brazilian Amazon region
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Gonçalves, Karen dos Santos
; Cirino, Glauber G.
; Costa, Marcelo Oliveira da
; Couto, Lucas de Oliveira do
; Tortelote, Giovane G.
; Hacon, Sandra de Souza
.
ABSTRACT OBJECTIVE This study aims to assess covid-19 morbidity, mortality, and severity from 2020 to 2021 in five Brazilian Amazon states with the highest records of wildfires. METHODS A distributed lag non-linear model was applied to estimate the potential exposure risk association with particulate matter smaller than 2.5-µm in diameter (PM2.5). Daily mean temperature, relative humidity, percentual of community mobility, number of hospital beds, days of the week, and holidays were considered in the final models for controlling the confounding factors. RESULTS The states of Para, Mato Grosso, and Amazonas have reported the highest values of overall cases, deaths, and severe cases of covid-19. The worrying growth in the percentual rates in 2020/2021 for the incidence, severity, and mortality were highlighted in Rondônia and Mato Grosso. The growth in 2020/2021 in the estimations of PM2.5 concentrations was higher in Mato Grosso, with an increase of 24.4%, followed by Rondônia (14.9%). CONCLUSION This study establishes an association between wildfire-generated PM2.5 and increasing covid-19 incidence, mortality, and severity within the studied area. The findings showed that the risk of covid-19 morbidity and mortality is nearly two times higher among individuals exposed to high concentrations of PM2.5. The attributable fraction to PM2.5 in the studied area represents an important role in the risk associated with covid-19 in the Brazilian Amazon region.
7.
Diretriz de Miocardites da Sociedade Brasileira de Cardiologia – 2022
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Montera, Marcelo Westerlund
; Marcondes-Braga, Fabiana G.
; Simões, Marcus Vinícius
; Moura, Lídia Ana Zytynski
; Fernandes, Fabio
; Mangine, Sandrigo
; Oliveira Júnior, Amarino Carvalho de
; Souza, Aurea Lucia Alves de Azevedo Grippa de
; Ianni, Bárbara Maria
; Rochitte, Carlos Eduardo
; Mesquita, Claudio Tinoco
; de Azevedo Filho, Clerio F.
; Freitas, Dhayn Cassi de Almeida
; Melo, Dirceu Thiago Pessoa de
; Bocchi, Edimar Alcides
; Horowitz, Estela Suzana Kleiman
; Mesquita, Evandro Tinoco
; Oliveira, Guilherme H.
; Villacorta, Humberto
; Rossi Neto, João Manoel
; Barbosa, João Marcos Bemfica
; Figueiredo Neto, José Albuquerque de
; Luiz, Louise Freire
; Hajjar, Ludhmila Abrahão
; Beck-da-Silva, Luis
; Campos, Luiz Antonio de Almeida
; Danzmann, Luiz Cláudio
; Bittencourt, Marcelo Imbroinise
; Garcia, Marcelo Iorio
; Avila, Monica Samuel
; Clausell, Nadine Oliveira
; Oliveira Jr, Nilson Araujo de
; Silvestre, Odilson Marcos
; Souza, Olga Ferreira de
; Mourilhe-Rocha, Ricardo
; Kalil Filho, Roberto
; Al-Kindi, Sadeer G.
; Rassi, Salvador
; Alves, Silvia Marinho Martins
; Ferreira, Silvia Moreira Ayub
; Rizk, Stéphanie Itala
; Mattos, Tiago Azevedo Costa
; Barzilai, Vitor
; Martins, Wolney de Andrade
; Schultheiss, Heinz-Peter
.
8.
Posicionamento sobre Diagnóstico e Tratamento da Amiloidose Cardíaca – 2021
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Simões, Marcus V.
; Fernandes, Fabio
; Marcondes-Braga, Fabiana G.
; Scheinberg, Philip
; Correia, Edileide de Barros
; Rohde, Luis Eduardo P.
; Bacal, Fernando
; Alves, Silvia Marinho Martins
; Mangini, Sandrigo
; Biolo, Andréia
; Beck-da-Silva, Luis
; Szor, Roberta Shcolnik
; Marques Junior, Wilson
; Oliveira, Acary Souza Bulle
; Cruz, Márcia Waddington
; Bueno, Bruno Vaz Kerges
; Hajjar, Ludhmila Abrahão
; Issa, Aurora Felice Castro
; Ramires, Felix José Alvarez
; Coelho Filho, Otavio Rizzi
; Schmidt, André
; Pinto, Ibraim Masciarelli Francisco
; Rochitte, Carlos Eduardo
; Valicelli, Flávio Henrique
; Vieira, Marcelo Luiz Campos
; Mesquita, Cláudio Tinoco
; Ramos, Celso Dario
; Soares-Junior, José
; Romano, Minna Moreira Dias
; Mathias Junior, Wilson
; Garcia Junior, Marcelo Iório
; Montera, Marcelo Westerlund
; Melo, Marcelo Dantas Tavares de
; Silva, Sandra Marques e
; Garibaldi, Pedro Manoel Marques
; Alencar Neto, Aristóteles Comte de
; Lopes, Renato Delascio
; Ávila, Diane Xavier de
; Viana, Denizar
; Saraiva, José Francisco Kerr
; Canesin, Manoel Fernandes
; Oliveira, Glaucia Maria Moraes de
; Mesquita, Evandro Tinoco
.
https://doi.org/10.36660/abc.20210718
330 downloads
9.
Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.
; Moura, Lídia Ana Zytynski
; Issa, Victor Sarli
; Vieira, Jefferson Luis
; Rohde, Luis Eduardo
; Simões, Marcus Vinícius
; Fernandes-Silva, Miguel Morita
; Rassi, Salvador
; Alves, Silvia Marinho Martins
; Albuquerque, Denilson Campos de
; Almeida, Dirceu Rodrigues de
; Bocchi, Edimar Alcides
; Ramires, Felix José Alvarez
; Bacal, Fernando
; Rossi Neto, João Manoel
; Danzmann, Luiz Claudio
; Montera, Marcelo Westerlund
; Oliveira Junior, Mucio Tavares de
; Clausell, Nadine
; Silvestre, Odilson Marcos
; Bestetti, Reinaldo Bulgarelli
; Bernadez-Pereira, Sabrina
; Freitas Jr, Aguinaldo F.
; Biolo, Andréia
; Barretto, Antonio Carlos Pereira
; Jorge, Antônio José Lagoeiro
; Biselli, Bruno
; Montenegro, Carlos Eduardo Lucena
; Santos Júnior, Edval Gomes dos
; Figueiredo, Estêvão Lanna
; Fernandes, Fábio
; Silveira, Fabio Serra
; Atik, Fernando Antibas
; Brito, Flávio de Souza
; Souza, Germano Emílio Conceição
; Ribeiro, Gustavo Calado de Aguiar
; Villacorta, Humberto
; Souza Neto, João David de
; Goldraich, Livia Adams
; Beck-da-Silva, Luís
; Canesin, Manoel Fernandes
; Bittencourt, Marcelo Imbroinise
; Bonatto, Marcely Gimenes
; Moreira, Maria da Consolação Vieira
; Avila, Mônica Samuel
; Coelho Filho, Otavio Rizzi
; Schwartzmann, Pedro Vellosa
; Mourilhe-Rocha, Ricardo
; Mangini, Sandrigo
; Ferreira, Silvia Moreira Ayub
; Figueiredo Neto, José Albuquerque de
; Mesquita, Evandro Tinoco
.
https://doi.org/10.36660/abc.20210367
3168 downloads
10.
Insecticide spray drift reduction with different adjuvants and spray nozzles
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Marubayashi, Rodrigo Y. P.
; Oliveira, Rone B. de
; Ferreira, Marcelo da C.
; Roggia, Samuel
; Moraes, Eder D. de
; Saab, Otavio J. G. A.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
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RESUMO A deriva da pulverização de inseticidas pode proporcionar a redução da eficiência de controle e perda para o ambiente. Desta forma, foi conduzido um estudo com o objetivo de estudar o efeito de diferentes pontas de pulverização e adição de adjuvantes na calda inseticida, em relação ao espectro de gotas e deriva em túnel de vento. Os experimentos foram conduzidos no delineamento inteiramente casualizado, com quatro repetições, no esquema fatorial 5 × 3, constituído por cinco caldas, uma apenas com água e outras quatro com inseticida tiametoxam + lambda-cialotrina (sem adjuvante, Oro-solve, Wetcit Gold e Orobor N1), combinadas com três pontas de pulverização (AXI, JFC e J3D). Foi avaliado o espectro das gotas, através do diâmetro mediano volumétrico, amplitude relativa e porcentagem do volume de gotas com diâmetro ≤ 100 µm. A deriva foi avaliada em túnel de vento, a diferentes distâncias: 5, 10 e 15 m. Os dados foram submetidos à análise de variância e as médias comparadas pelo teste de Tukey. Além disso, foram realizadas análises de componentes principais. A aplicação do inseticida com os adjuvantes combinados com as diferentes pontas de pulverização alterou o espectro de gotas e o risco da deriva. A ponta AXI e a J3D associada aos adjuvantes Oro-solve e Wetcit Gold apresentaram maiores diâmetros medianos volumétricos das gotas e deriva a 5 m.
ABSTRACT Insecticide spray drift can lead to reduced control efficiency and loss of product to the environment. Thus, we conducted a study to evaluate the effect of different spray nozzles and the addition of adjuvants in insecticide spray on the resulting droplet spectrum and wind tunnel drift. All experiments were conducted in a completely randomized design with four repetitions using a 5 × 3 factorial scheme. Five spraying solutions were studied; one contained only water and the other four comprised thiamethoxam + lambda-cyhalothrin (no adjuvant, Oro-solve, Wetcit Gold, and Orobor N1), in combination with three spray nozzles (AXI, JFC, and J3D). The droplet spectrum was evaluated through the volumetric median diameter, relative amplitude, and percentage of the droplet volume with diameter ≤ 100 µm. The drifts were evaluated in a wind tunnel at 5, 10, and 15 m. Data were subjected to analysis of variance and means were compared using the Tukey’s test. In addition, a principal component analysis was performed. Application of the insecticide with the adjuvants combined with the different nozzles changed the droplet spectrum and the risk of drift. The AXI nozzle and the J3D associated with the Oro-solve and Wetcit Gold adjuvants resulted in a greater volumetric median diameter of the droplets and drifts were observed at 5 m.
https://doi.org/10.1590/1807-1929/agriambi.v25n4p282-287
278 downloads
11.
Práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras: uma análise secundária do estudo Fluid-TRIPS
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Freitas, Flavio Geraldo Rezende de
; Hammond, Naomi
; Li, Yang
; Azevedo, Luciano Cesar Pontes de
; Cavalcanti, Alexandre Biasi
; Taniguchi, Leandro
; Gobatto, André
; Japiassú, André Miguel
; Bafi, Antonio Tonete
; Mazza, Bruno Franco
; Noritomi, Danilo Teixeira
; Dal-Pizzol, Felipe
; Bozza, Fernando
; Salluh, Jorge Ibrahin Figueira
; Westphal, Glauco Adrieno
; Soares, Márcio
; Assunção, Murillo Santucci César de
; Lisboa, Thiago
; Lobo, Suzana Margarete Ajeje
; Barbosa, Achilles Rohlfs
; Ventura, Adriana Fonseca
; Souza, Ailson Faria de
; Silva, Alexandre Francisco
; Toledo, Alexandre
; Reis, Aline
; Cembranel, Allan
; Rea Neto, Alvaro
; Gut, Ana Lúcia
; Justo, Ana Patricia Pierre
; Santos, Ana Paula
; Albuquerque, André Campos D. de
; Scazufka, André
; Rodrigues, Antonio Babo
; Fernandino, Bruno Bonaccorsi
; Silva, Bruno Goncalves
; Vidal, Bruno Sarno
; Pinheiro, Bruno Valle
; Pinto, Bruno Vilela Costa
; Feijo, Carlos Augusto Ramos
; Abreu Filho, Carlos de
; Bosso, Carlos Eduardo da Costa Nunes
; Moreira, Carlos Eduardo Nassif
; Ramos, Carlos Henrique Ferreira
; Tavares, Carmen
; Arantes, Cidamaiá
; Grion, Cintia
; Mendes, Ciro Leite
; Kmohan, Claudio
; Piras, Claudio
; Castro, Cristine Pilati Pileggi
; Lins, Cyntia
; Beraldo, Daniel
; Fontes, Daniel
; Boni, Daniela
; Castiglioni, Débora
; Paisani, Denise de Moraes
; Pedroso, Durval Ferreira Fonseca
; Mattos, Ederson Roberto
; Brito Sobrinho, Edgar de
; Troncoso, Edgar M. V.
; Rodrigues Filho, Edison Moraes
; Nogueira, Eduardo Enrico Ferrari
; Ferreira, Eduardo Leme
; Pacheco, Eduardo Souza
; Jodar, Euzebio
; Ferreira, Evandro L. A.
; Araujo, Fabiana Fernandes de
; Trevisol, Fabiana Schuelter
; Amorim, Fábio Ferreira
; Giannini, Fabio Poianas
; Santos, Fabrício Primitivo Matos
; Buarque, Fátima
; Lima, Felipe Gallego
; Costa, Fernando Antonio Alvares da
; Sad, Fernando Cesar dos Anjos
; Aranha, Fernando G.
; Ganem, Fernando
; Callil, Flavio
; Costa Filho, Francisco Flávio
; Dall´Arto, Frederico Toledo Campo
; Moreno, Geovani
; Friedman, Gilberto
; Moralez, Giulliana Martines
; Silva, Guilherme Abdalla da
; Costa, Guilherme
; Cavalcanti, Guilherme Silva
; Cavalcanti, Guilherme Silva
; Betônico, Gustavo Navarro
; Betônico, Gustavo Navarro
; Reis, Hélder
; Araujo, Helia Beatriz N.
; Hortiz Júnior, Helio Anjos
; Guimaraes, Helio Penna
; Urbano, Hugo
; Maia, Israel
; Santiago Filho, Ivan Lopes
; Farhat Júnior, Jamil
; Alvarez, Janu Rangel
; Passos, Joel Tavares
; Paranhos, Jorge Eduardo da Rocha
; Marques, José Aurelio
; Moreira Filho, José Gonçalves
; Andrade, Jose Neto
; Sobrinho, José Onofre de C
; Bezerra, Jose Terceiro de Paiva
; Alves, Juliana Apolônio
; Ferreira, Juliana
; Gomes, Jussara
; Sato, Karina Midori
; Gerent, Karine
; Teixeira, Kathia Margarida Costa
; Conde, Katia Aparecida Pessoa
; Martins, Laércia Ferreira
; Figueirêdo, Lanese
; Rezegue, Leila
; Tcherniacovsk, Leonardo
; Ferraz, Leone Oliveira
; Cavalcante, Liane
; Rabelo, Ligia
; Miilher, Lilian
; Garcia, Lisiane
; Tannous, Luana
; Hajjar, Ludhmila Abrahão
; Paciência, Luís Eduardo Miranda
; Cruz Neto, Luiz Monteiro da
; Bley, Macia Valeria
; Sousa, Marcelo Ferreira
; Puga, Marcelo Lourencini
; Romano, Marcelo Luz Pereira
; Nobrega, Marciano
; Arbex, Marcio
; Rodrigues, Márcio Leite
; Guerreiro, Márcio Osório
; Rocha, Marcone
; Alves, Maria Angela Pangoni
; Alves, Maria Angela Pangoni
; Rosa, Maria Doroti
; Dias, Mariza D’Agostino
; Martins, Miquéias
; Oliveira, Mirella de
; Moretti, Miriane Melo Silveira
; Matsui, Mirna
; Messender, Octavio
; Santarém, Orlando Luís de Andrade
; Silveira, Patricio Júnior Henrique da
; Vassallo, Paula Frizera
; Antoniazzi, Paulo
; Gottardo, Paulo César
; Correia, Paulo
; Ferreira, Paulo
; Torres, Paulo
; Silva, Pedro Gabrile M. de Barros e
; Foernges, Rafael
; Gomes, Rafael
; Moraes, Rafael
; Nonato filho, Raimundo
; Borba, Renato Luis
; Gomes, Renato V
; Cordioli, Ricardo
; Lima, Ricardo
; López, Ricardo Pérez
; Gargioni, Ricardo Rath de Oliveira
; Rosenblat, Richard
; Souza, Roberta Machado de
; Almeida, Roberto
; Narciso, Roberto Camargo
; Marco, Roberto
; waltrick, Roberto
; Biondi, Rodrigo
; Figueiredo, Rodrigo
; Dutra, Rodrigo Santana
; Batista, Roseane
; Felipe, Rouge
; Franco, Rubens Sergio da Silva
; Houly, Sandra
; Faria, Sara Socorro
; Pinto, Sergio Felix
; Luzzi, Sergio
; Sant’ana, Sergio
; Fernandes, Sergio Sonego
; Yamada, Sérgio
; Zajac, Sérgio
; Vaz, Sidiner Mesquita
; Bezerra, Silvia Aparecida Bezerra
; Farhat, Tatiana Bueno Tardivo
; Santos, Thiago Martins
; Smith, Tiago
; Silva, Ulysses V. A.
; Damasceno, Valnei Bento
; Nobre, Vandack
; Dantas, Vicente Cés de Souza
; Irineu, Vivian Menezes
; Bogado, Viviane
; Nedel, Wagner
; Campos Filho, Walther
; Dantas, Weidson
; Viana, William
; Oliveira Filho, Wilson de
; Delgadinho, Wilson Martins
; Finfer, Simon
; Machado, Flavia Ribeiro
.
RESUMO Objetivo: Descrever as práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras e compará-las com as de outros países participantes do estudo Fluid-TRIPS. Métodos: Este foi um estudo observacional transversal, prospectivo e internacional, de uma amostra de conveniência de unidades de terapia intensiva de 27 países (inclusive o Brasil), com utilização da base de dados Fluid-TRIPS compilada em 2014. Descrevemos os padrões de ressuscitação volêmica utilizados no Brasil em comparação com os de outros países e identificamos os fatores associados com a escolha dos fluidos. Resultados: No dia do estudo, foram incluídos 3.214 pacientes do Brasil e 3.493 pacientes de outros países, dos quais, respectivamente, 16,1% e 26,8% (p < 0,001) receberam fluidos. A principal indicação para ressuscitação volêmica foi comprometimento da perfusão e/ou baixo débito cardíaco (Brasil 71,7% versus outros países 56,4%; p < 0,001). No Brasil, a percentagem de pacientes que receberam soluções cristaloides foi mais elevada (97,7% versus 76,8%; p < 0,001), e solução de cloreto de sódio a 0,9% foi o cristaloide mais comumente utilizado (62,5% versus 27,1%; p < 0,001). A análise multivariada sugeriu que os níveis de albumina se associaram com o uso tanto de cristaloides quanto de coloides, enquanto o tipo de prescritor dos fluidos se associou apenas com o uso de cristaloides. Conclusão: Nossos resultados sugerem que cristaloides são usados mais frequentemente do que coloides para ressuscitação no Brasil, e essa discrepância, em termos de frequências, é mais elevada do que em outros países. A solução de cloreto de sódio 0,9% foi o cristaloide mais frequentemente prescrito. Os níveis de albumina sérica e o tipo de prescritor de fluidos foram os fatores associados com a escolha de cristaloides ou coloides para a prescrição de fluidos.
Abstract Objective: To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods: This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results: On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion: Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation.
https://doi.org/10.5935/0103-507x.20210028
273 downloads
12.
INCORPORAÇÃO DE RODAMINA B EM MEMBRANA DE POLIAMIDA PELO MÉTODO DA ADSORÇÃO
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Sousa, Kalil Z. R. de
; Faria, Emerson H. de
; Marçal, Liziane
; Ciuffi, Katia J.
; Ricci, Emiliane G.
; Rocha, Lucas A.
; Nassar, Eduardo J.
; Silva, Jorge V. L.
; Oliveira, Marcelo F.
; Maia, Izaque A.
.
We have incorporated rhodamine into polyamide membranes by additive manufacture selective laser sintering technology. Incorporation into 0.5 cm2 membranes was conducted at different pH values and constant temperature of 25 oC. The amounts of incorporated dye were determined by a calibration curve, and analyses showed rhodamine incorporation in the order of 10-6 mol L-1. The absorption spectra of the solutions and membranes after rhodamine incorporation showed maximum absorption at 553 nm and a shoulder at 522 nm, which indicated that a dimer was formed. Photoluminescence presented maximum emission at 575 nm for the sample incorporated with rhodamine in acid pH. The membranes that were treated with acid presented shorter adsorption time and demanded 180 min to reach equilibrium, whereas the non-treated membrane and the membranes that were treated with base required 1440 min to reach equilibrium. Polyamide membrane has proven to be an excellent material for the incorporation of dyes and compounds for application as luminescent sensors.
https://doi.org/10.21577/0100-4042.20170670
134 downloads
13.
Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues
; Besen, Bruno Adler Maccagnan Pinheiro
; Lima, Clarice Antunes de
; Corá, Aline Pivetta
; Pereira, Antônio José Rodrigues
; Perazzio, Sandro Félix
; Gouvea, Christiane Pereira
; Fonseca, Luiz Augusto Marcondes
; Trindade, Evelinda Marramon
; Sumita, Nairo Massakazu
; Duarte, Alberto José da Silva
; Lichtenstein, Arnaldo
; Bonfa, Eloisa
; Utiyama, Edivaldo M.
; Segurado, Aluisio C.
; Perondi, Beatriz
; Miethke-Morais, Anna
; Montal, Amanda C.
; Harima, Leila
; Fusco, Solange R. G.
; Silva, Marjorie F.
; Rocha, Marcelo C.
; Marcilio, Izabel
; Rios, Izabel Cristina
; Kawano, Fabiane Yumi Ogihara
; Jesus, Maria Amélia de
; Kallas, Ésper George
; Carmo, Carolina
; Tanaka, Clarice
; Souza, Heraldo Possolo de
; Marchini, Julio F. M.
; Carvalho, Carlos
; Ferreira, Juliana C.
; Levin, Anna Sara Shafferman
; Oliveira, Maura Salaroli
; Guimarães, Thaís
; Lázari, Carolina dos Santos
; Sabino, Ester
; Magri, Marcello M. C.
; Barros-Filho, Tarcisio E. P.
; Francisco, Maria Cristina Peres Braido
; Costa, Silvia F.
.
OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.
14.
Sudden death in a rat model of Parkinson’s disease
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Scorza, Fulvio Alexandre
; Rodrigues, Laís Damasceno
; Oliveira, Leandro Freitas
; Almeida, Antônio Carlos G. de
; Finsterer, Josef
; Moret, Marcelo A.
; Cardillo, Giancarlo de Mattos
; Scorza, Carla Alessandra
.
https://doi.org/10.6061/clinics/2021/e2974
200 downloads
15.
Genetic diversity in two threatened species of guitarfish (Elasmobranchii: Rhinobatidae) from the Brazilian and Argentinian coasts: an alert for conservation
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Cruz, Vanessa P.
; Adachi, Aisni M.C. L.
; Oliveira, Pablo H.
; Ribeiro, Giovana S.
; Paim, Fabilene G.
; Souza, Bruno C.
; Rodrigues, Alexandre S.F.
; Vianna, Marcelo
; Delpiani, Sergio M.
; Díaz de Astarloa, Juan Martín
; Rotundo, Matheus M.
; Mendonça, Fernando F.
; Oliveira, Claudio
; Lessa, Rosangela P.
; Foresti, Fausto
.
Resumo As raias violas Pseudobatos horkelii e Pseudobatos percellens, são listados como “Criticamente em Perigo” (CR) e “Em Perigo” (EN), respectivamente. Ambas as espécies ocorrem no Sul do Oceano Atlântico. Considerando a falta de dados sobre a estrutura genética dessas espécies, o presente estudo avaliou a variabilidade genética e a estrutura populacional de P. horkelii e P. percellens na região sudeste do Brasil e litoral norte da Argentina, com base em sequências de DNA mitocondrial, região de controle (D-loop). Amostras de 135 indivíduos de P. horkelii analisados em seis localidades, situadas no norte da Argentina e ao longo da costa dos estados brasileiros. A média da diversidade nucleotídica foi de 0.0053, o índice ΦST foi de 0.4277 e a análise demográfica de P. horkelii, indicou a existência de estabilidade das populações, com D = 0.9929, Fus = 2.0155, SSD = 0.0817, R = 0.2153. Em 101 exemplares de P. percellens, foram analisados em seis localidades brasileiras ao longo do litoral de Santa Catarina, Paraná e São Paulo. A diversidade nucleotídica média foi de 0.0014 e o valor ΦST de 0.2921, a análise demográfica indicou uma alta taxa de migração de P. percellens entre as localidades analisadas, com D = 0.5222, FS = 0.3528, SSD = 0.01785, R = 0.3890.
Abstract The guitarfishes Pseudobatos horkelii and Pseudobatos percellens meet the criteria for threatened status as Critically Endangered (CR) and Endangered (EN), respectively. Both species occur in the Southern Atlantic Ocean. Considering the lack of data on the genetic structure of these species, the present study evaluated the genetic variability and population structure of the P. horkelii and P. percellens in the southern region of Brazil and the northern coast of Argentina, based on sequences of mitochondrial DNA, Control Region (D-loop). Samples of P. horkelii (n = 135) were analyzed in six localities situated in Northern Argentina, along the Brazilian states’ coast. The mean of nucleotide diversity was 0.0053, the ΦST was 0.4277 and demographic analysis of P. horkelii suggests the existence of stability of the populations, with D = 0.9929, FS = 2.0155, SSD = 0.0817, R = 0.2153. In P. percellens (n = 101) were analyzed from six Brazilian localities along the coast of Santa Catarina, Paraná, and São Paulo. The mean nucleotide diversity was 0.0014 and ΦST value of 0.2921, the demographic analysis indicates a high migration rate of P. percellens among the localities evaluated, with D = 0.5222, FS = 0.3528, SSD = 0.01785, R = 0.3890.
https://doi.org/10.1590/1982-0224-2021-0012
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