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Cancer is one of the major causes of death worldwide, and breast cancer is the most prevalent and deadly type among women. Despite the side effects and the phenomena of chemoresistance associated with the drugs involved, chemotherapy remains the main therapeutic strategy to combat and control breast cancer. Therefore, several new classes of compounds against breast cancer have been explored, in an effort to identify new drug candidates with alternative mechanisms of action. The principal results of such exploration, focusing on caged xanthones, thiosemicarbazones and photosensitizers, are presented in this review, along with the main aspects of the drug discovery process against breast cancer. More specifically, the design, structure-activity relationship investigations and anti-breast cancer properties of these three classes are described and discussed in this work. worldwide women involved Therefore explored action exploration xanthones photosensitizers review specifically design structureactivity structure activity antibreast anti work

https://doi.org/10.21577/0103-5053.20230128

Capillary Electromigration Techniques Applied to Clinical Chemistry Investigations and Alternative Diagnostic Assays: Possibilities and Perspectives Assays
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Moreira, Olívia B. O.

; Berlande, Bruna M.

; Souza, Jéssica C. Q. de

; Candido, João Marcos B.

; Jaeger, Lauren H.

; Adriano, Luiz Henrique C.

; Brito, Marco Antônio D. A. e

; Nascimento, Maria Patrícia do

; Geraldo, Patrícia A.

; Chellini, Paula R.

; Oliveira, Marcone Augusto L. de

Journal of the Brazilian Chemical Society

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nov 2023, Volume 34 N. 11 Pages 1542 - 1564

Abstract: En | Text: En | PDF: En

Capillary electromigration techniques can be understood as the ones used to separate neutral compounds, solvated ions and ionized species, considering the differentiated migration among them when an electrical field is applied within a capillary column filled with a background electrolyte. Several existing capillary electrophoresis setups provide the possibility of developing reliable quantitative assays of inorganic ions, organic acids, fatty acids, amino acids, carbohydrates, nucleic acids, proteins, hormones, vitamins, macromolecules, and more. Therefore, given the chemical complexity of bodily fluid matrices, capillary electrophoresis (CE) and its variations present themselves as an advantageous strategy for enhancing traditional clinical diagnostic methods and for the development of new ones. The recent advances in the study of the human metabolome associated with technological improvements towards medical applications make CE a very useful and versatile technique for clinical laboratory assays. Within this context, this review has the purpose of presenting some traditional methods used for exams of blood, urine, saliva, feces, and sweat, and how CE can be implemented as a real alternative to enable faster, automated, and cost-effective analysis with a comprehensive perspective that shall result in better diagnostic possibilities for patients, being a powerful tool for helping physicians on the precision medicine achievements. compounds species electrolyte acids carbohydrates proteins hormones vitamins macromolecules more Therefore matrices (CE context blood urine saliva feces sweat faster automated costeffective cost effective patients achievements

https://doi.org/10.21577/0103-5053.20230096

Análise de Perícias Psicológicas de Trânsito: Um Olhar sobre os Construtos Cognitivos
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Souza, Patrícia Emi de

; Oliveira, Katya Luciane de

; Rueda, Fabián J. M.

; Inácio, Amanda Lays Monteiro

Psico-USF

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oct 2023, Volume 28 N. 4 Pages 697 - 710

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract The objective of this research was to analyze psychological tests conducted in cities in the state of Paraná in the year 2019, focusing on cognitive aspects. For this purpose, we examined 1009 records from clinics accredited to the State Traffic Department of Paraná (DETRAN-Pr). The results, inherent to the characterization of the expertise, pointed out that the participants had an average age of 27 years, 44.4% had completed secondary education, 72.2% were first-time applicants, and 61% had the A/B category. Twelve types of standardized Psychological Assessment instruments were found. The results indicated that participants exhibited an average performance in these instruments, and there was a significant correlation between the main constructs investigated. These findings suggest that, in addition to maintaining cognitive skills, providing driver education starting from elementary school could significantly contribute to enhancing road safety.

Resumen El objetivo de la investigación fue analizar las pruebas psicológicas realizadas en ciudades de Paraná en el año 2019 sobre aspectos cognitivos. Para ello se consultaron 1009 expedientes archivados en clínicas acreditadas ante el Departamento de Tránsito de Paraná (DETRAN-Pr). Los resultados, inherentes a la caracterización de la especialización, apuntaron que los participantes tenían una edad media de 27 años, 44,4% tenían estudios secundarios completos, 72,2% para el 1º título, 61% para la categoría A/B. Se encontraron doce tipos de instrumentos de Evaluación Psicológica estandarizados. Los resultados muestran un desempeño promedio en los instrumentos y una relación de dependencia entre los principales constructos investigados. Se considera que, además de preservar las habilidades cognitivas, la formación de los conductores desde la escuela primaria en adelante es un importante contribuyente a la seguridad del tráfico.

Resumo O objetivo da pesquisa foi analisar perícias psicológicas realizadas em cidades do Paraná do ano de 2019 no que tange aos aspectos cognitivos. Para tanto, foram consultados 1009 processos arquivados em clínicas credenciadas ao Departamento de Trânsito do Paraná (DETRAN-Pr). Os resultados, inerentes à caracterização das perícias, apontaram que os participantes com idade média de 27 anos, 44,4% possuindo ensino médio completo, 72,2% para a 1ª habilitação, 61% para a categoria A/B. Foram encontrados 12 tipos de instrumentos de Avaliação Psicológica padronizados. Os resultados apontam desempenho médio nos instrumentos e relação de dependência entre os principais construtos investigados. Considera-se que, além de habilidades cognitivas preservadas, a formação dos condutores desde o ensino básico é importante contribuinte para o trânsito seguro.

https://doi.org/10.1590/1413-82712023280404

[SciELO Preprints] - Preservation of moderately resistant or tolerant genotypes: a strategy to overcome guava decline
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Silva, Maurício Moisés Pereira Queiróz, Manoel Abilio de Oliveira, Patrícia Gomes Coutinho, Milena dos Santos Mauro da Cunha e Castro, José Mauro da Cunha e Castro

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Publication date: 2023-08-14

Abstract: En Pt

Originária da América Tropical, a goiabeira ( Psidium guajava L. ) tem grande símbolo para o Brasil. Contudo, a evolução do patossistema designado como declínio da goiabeira, problema fitossanitário provocado pelo parasitismo das raízes pelo nematoide-das-galhas ( Meloidogyne enterolobii Yang & Eisenback) em associação com fungos oportunistas, dizimou muitos pomares em todas as regiões do Brasil e em outros países. No presente estudo, propagou-se vegetativamente, por miniestaquia, acessos de goiabeiras seminíferas mantendo seus genótipos preservados e reavaliando a resistência por meio dos clones de forma a comprovar ou não as reações das plantas hospedeiras. Os resultados apontam para alta virulência do parasita, bem como alta hospedabilidade da espécieP. guajava , além da existência de grande variação da reação entre plantas do mesmo genótipo e entre genótipos distintos, o que indica que a estratégia de preservação do germoplasma e a reavaliação da reação em clones pode ser importante na busca e seleção de germoplasma com algum grau de ou resistência de tolerância a M. enterolobii . A progênie da cv. Paluma P02R5R2 obteve uma menor média de Fator de Reprodução do parasita (FR = 22,11) entre os genótipos avaliados, sendo classificado como moderadamente resistente e preservado para estudos posteriores.

Originária da América Tropical, a cultura da goiabeira (Psidium guajava L.) tem grande relevância para o Brasil. Contudo, surgimento do patossistema designado como declínio da goiabeira, problema fitossanitário provocado pelo parasitismo das raízes por nematoides da espécie Meloidogyne enterolobii Yang & Eisenback em associação com fungos oportunistas, dizimou muitos pomares em todas as regiões do Brasil e em outros países. No presente estudo, propagou-se vegetativamente, por miniestaquia, acessos de goiabeiras seminíferas mantendo seus genótipos preservados e reavaliando a resistência por meio dos clones de forma a comprovar ou não as reações das plantas hospedeiras. Os resultados apontam para alta virulência do parasita, bem como alta hospedabilidade da espécie P. guajava, além da existência de grande variação da reação entre plantas do mesmo genótipo e entre genótipos distintos, o que indica que a estratégia de preservação do germoplasma e a reavaliação da reação em clones pode ser importante na busca e seleção de germoplasma com algum grau de resistência ou características de tolerância ao M. enterolobii. A progênie da cv. Paluma P02R5R2 obteve a menor média de Fator de Reprodução do parasita (FR = 22,11) entre os genótipos avaliados, sendo classificada como moderadamente resistente e preservada para estudos posteriores.

https://doi.org/10.1590/SciELOPreprints.4678

Fitting Structure-Data Files (.SDF) Libraries to Progenesis QI Identification Searches
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Sanches, Pedro H. G.

; Oliveira, Danilo C. de

; Reis, Ivan G. M. dos

; Fernandes, Anna M. A. P.

; Silva, Alex A. R.

; Eberlin, Marcos N.

; Carvalho, Patrícia O.

; Duarte, Gustavo H. B.

; Porcari, Andreia M.

Journal of the Brazilian Chemical Society

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jul 2023, Volume 34 N. 7 Pages 1013 - 1019

Abstract: En | Text: En | PDF: En

Progenesis QI (PQI) is a multiplatform bioinformatics tool that facilitates the identification workflow for metabolomics experiments. PQI uses fragmentation data provided by MassBank of North America (MoNA) libraries, among others, for metabolite annotation. However, PQI does not officially support MoNA libraries and other libraries based on structure-data files (.sdf). This paper describes the development and application of a software named MoNA to Progenesis QI Library Converter, allowing PQI and MoNA by correcting the fragmentation data of the library for Progenesis readability. We evaluated several public experimental datasets, including human plasma, plant extracts, cultured cells, bacteria, rat serum, and rat hippocampus. The results showed that it is mandatory to proceed with file conversion of each library to allow PQI to access fragmentation information from .msp (main spectra profile) files. This step is highly recommended to improve the identification level of the metabolites.

https://doi.org/10.21577/0103-5053.20230016

New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing
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Anselmo, Lívia Maria Pala

; Gallo, Juliana Failde

; Pinhata, Juliana Maira Watanabe

; Peronni, Kamila Chagas

; Silva Junior, Wilson Araújo da

; Ruy, Patricia de Cássia

; Conceição, Emilyn Costa

; Dippenaar, Anzaan

; Warren, Robin Mark

; Monroe, Aline Aparecida

; Oliveira, Rosangela Siqueira

; Bollela, Valdes Roberto

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0181-2022

Abstract: En | Text: En | PDF: En

ABSTRACT Background: The rate of tuberculosis (TB) infection among the prison population (PP) in Brazil is 28 times higher than that in the general population, and prison environment favors the spread of TB. Objective: To describe TB transmission dynamics and drug resistance profiles in PP using whole-genome sequencing (WGS). Methods: This was a retrospective study of Mycobacterium tuberculosis cultivated from people incarcerated in 55 prisons between 2016 and 2019; only one isolate per prisoner was included. Information about movement from one prison to another was tracked. Clinical information was collected, and WGS was performed on isolates obtained at the time of TB diagnosis. Results: Among 134 prisoners included in the study, we detected 16 clusters with a total of 58 (43%) cases of M. tuberculosis. Clusters ranged from two to seven isolates with five or fewer single nucleotide polymorphism (SNP) differences, suggesting a recent transmission. Six (4.4%) isolates were resistant to at least one anti-TB drug. Two of these clustered together and showed resistance to rifampicin, isoniazid, and fluoroquinolones, with 100% concordance between WGS and phenotypic drug-susceptibility testing. Prisoners with clustered isolates had a high amount of movement between prisons (two to eight moves) during the study period. Conclusions: WGS demonstrated the recent transmission of TB within prisons in Brazil. The high movement among prisoners seems to be related to the transmission of the same M. tuberculosis strain within the prison system. Screening for TB before and after the movement of prisoners using rapid molecular tests could play a role in reducing transmission.

https://doi.org/10.1590/0037-8682-0181-2022

Silver Nanocatalyst Supported on Waste-Based Polystyrene Foam for Thermal and Plasmonic Reduction of p-Nitrophenol
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Silva, Welida T. A. da

; Assis, Geovânia C. de

; Jesus, Roberta A. de

; Motta, Rayssa J. B.

; Ferreira, Luiz Fernando R.

; Ruiz, Yolice Patricia M.

; Galembeck, André

; Schneider, Ricardo

; Oliveira, Rodrigo J. de

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 9 Pages 1317 - 1332

Abstract: En | Text: En | PDF: En

Disposal of plastics into the environment has been one of the major problems for the environment. The accumulation of polystyrene (PS) occurs in an accelerated way and, therefore, its reuse is challenging. Polystyrene nanocomposites impregnated with Ag nanoparticles (PS/AgNP) are generated from polystyrene residues and can be applied in the catalytic and plasmonic photo-catalytic reduction of phenolic compounds such as p-nitrophenol (PNP) to p-aminophenol (PAP). The AgNP were synthesized by a reverse micelle method resulting in nanoparticles with sizes in a range of 31.1-34.0 nm. The organocolloid was characterized by UV Vis and dynamic light scattering (DLS), demonstrating the preparation of spherical nanoparticles. The preparation of the PS/AgNP, obtained using a thermally induced phase separation method (TIPS), was confirmed by means of scanning electron microscopy (SEM), X-ray diffraction (XRD), laser-induced breakdown spectroscopy (LIBS), and Fourier transform visible infrared spectroscopy (FTIR). Nanocomposites showed impressive performance in the catalytic and plasmonic photocatalytic reduction under blue light irradiation, reaching up to 98% conversion, being a promising material for wastewater treatment as well as other various environmental issues. We used blue light to observe the plasmonic effect of silver nanoparticles, and no previous reports of this composite for PNP reduction using blue light photocatalysis were found.

https://doi.org/10.21577/0103-5053.20230044

Wood Properties of 38-year-old Cariniana legalis (Mart.) Kuntze Based on Planting Spacing
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De Lima, Israel Luiz

; Rosada de Oliveira, Ivanka

; Gurgel Vicentin, Patrícia

; Ranzini, Maurício

; Nivaldo Garcia, José

; Longui, Eduardo Luiz

Colombia Forestal

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dec 2022, Volume 25 N. 2 Pages 5 - 16

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract This study aimed to analyze the properties of 38-year-old Cariniana legalis wood from trees planted with three spacings between trees: 3 × 2.5, 3 × 2, and 3 × 1.5 m. Five trees were collected from each tree spacing. Discs were collected from the trunk base of each tree and at 2.5 and 5.0 m. The vessel diameter was significantly wider for a spacing of 3 x 2.5 m compared to that of 3 x 1.5 m. Basic density, apparent density, volumetric shrinkage, and natural moisture content were influenced by longitudinal position. However, fiber length and fiber wall thickness showed no significant differences. Basic density and natural moisture content were inversely proportional. Our study shows that the anatomical features of C. legalis wood were more sensitive to variations in tree spacing than its physical properties.

Resumen El objetivo de este estudio fue analizar las propiedades de la madera árboles de Cariniana legalis de 38 años plantados con tres espaciamientos: 3 × 2.5, 3 × 2 y 3 × 1.5 m. Se cortaron cinco árboles por cada espaciamiento. Se recolectaron discos de la base del tronco de cada árbol y a 2.5 y 5.0 m. El diámetro de los vasos fue significativamente más ancho en el espaciamiento de 3 x 2.5 m en contraste con el de 3 x 1.5 m. La densidad básica, la densidad aparente, la contracción volumétrica y el contenido de humedad natural fueron influenciados por la posición longitudinal. Sin embargo, la longitud de la fibra y el grosor de la pared de la fibra no presentaron diferencias significativas. La densidad básica y el contenido de humedad natural fueron inversamente proporcionales. Nuestro estudio muestra que las características anatómicas de la madera de C. legalis fueron más sensibles a la variación del espaciamiento entre árboles que sus propiedades físicas.

https://doi.org/10.14483/2256201x.19037 19 downloads

Revisão sistemática sobre o efeito do programa escolar de prevenção ao uso de drogas Keepin’ it REAL: traduzido e implementado no Brasil pelo PROERD
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Valente, Juliana Y.

; Galvão, Patricia Paiva de Oliveira

; Gusmoes, Julia Dell Sol Passos

; Sanchez, Zila M.

Ciência & Saúde Coletiva

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nov 2022, Volume 27 N. 11 Pages 4175 - 4189

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O Programa Educacional de Resistência às Drogas (PROERD) é o programa escolar de prevenção mais disseminado no Brasil, seu atual currículo é baseado no programa norte-americano Keepin’it REAL (kiR). Não há na literatura evidência de efetividade do PROERD na prevenção ao uso de drogas, sendo necessários estudos complementares que auxiliem a compreensão desses achados. O objetivo do presente estudo é realizar uma síntese das evidências do efeito do currículo que deu origem ao PROERD: o kiR. Através de revisão sistemática encontrou-se 17 estudos que reportaram resultados de efeito de diferentes versões do kiR no uso de drogas e/ou violência. Com exceção do estudo brasileiro, não foram encontrados estudos que avaliassem o efeito no uso de drogas da versão aplicada por policiais (DARE-kiR), a mesma implementada pelo PROERD. Foram encontradas evidências favoráveis do kiR na prevenção ao uso de drogas para o currículo do 7º ano, que contrariam os resultados de efeito nulo do PROERD. Não foram encontradas evidências internacionais do efeito do kiR no currículo do 5º ano, assim como o estudo do PROERD. Sugere-se que revisões no currículo do 7º ano do PROERD para que ele possa refletir os resultados internacionais e que o currículo do 5º ano posso ser repensado considerando as evidências negativas internacionais.

Abstract The Drug Resistance Educational Program (PROERD) is Brazil’s most widespread school-based prevention program; its current curriculum is based on the North American Keepin’ it REAL (kiR) program. There is no evidence of the effectiveness of PROERD in preventing drug use, pointing to the need for further studies to understand these findings. The aim of the study was to synthesis the evidence of the effect of the kiR curriculum (PROERD) through a systematic review. We found 17 studies that reported the effects of different versions of kiR on drug use and/or violence. Except for the Brazilian study, no studies were found that assessed the effect on drug use of the version applied by police officers (DARE-kiR), the same one implemented by PROERD. Favorable evidence of kiR in drug use prevention was found for the 7th-grade curriculum, which contradicts the PROERD’s null-effect results. No international evidence of the effect of kiR was found in the 5th-grade curriculum, in the same line as the PROERD’s study. It is suggested that PROERD’s 7th-grade curriculum should be revised to reflect international results and that the 5th-grade curriculum should be reconsidered in light of the negative international evidence.

https://doi.org/10.1590/1413-812320222711.07162022

10.

Revisão sistemática sobre o efeito do programa escolar de prevenção ao uso de drogas Keepin’ it REAL: traduzido e implementado no Brasil pelo PROERD
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Valente, Juliana Y.

; Galvão, Patricia Paiva de Oliveira

; Gusmoes, Julia Dell Sol Passos

; Sanchez, Zila M.

Ciência & Saúde Coletiva

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nov 2022, Volume 27 N. 11 Pages 4175 - 4189

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320222711.07162022

11.

Diretriz da Sociedade Brasileira de Cardiologia sobre a Análise e Emissão de Laudos Eletrocardiográficos – 2022
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Samesima, Nelson

; God, Epotamenides Good

; Kruse, Jose Claudio Lupi

; Leal, Marcelo Garcia

; Pinho, Claudio

; França, Francisco Faustino de A. C.

; Pimenta, João

; Cardoso, Acácio Fernandes

; Paixão, Adail

; Fonseca, Alfredo

; Pérez-Riera, Andrés R.

; Ribeiro, Antonio Luiz Pinho

; Madaloso, Bruna Affonso

; Luna Filho, Bráulio

; Oliveira, Carlos Alberto Rodrigues de

; Grupi, César José

; Moreira, Dalmo Antonio Ribeiro

; Kaiser, Elisabeth

; Paixão, Gabriela Miana de Mattos

; Feitosa Filho, Gilson

; Pereira Filho, Horacio Gomes

; Grindler, José

; Aziz, José Luiz

; Molina, Marcos Sleiman

; Facin, Mirella

; Tobias, Nancy M. M. de Oliveira

; Oliveira, Patricia Alves de

; Sanches, Paulo César R.

; Teixeira, Ricardo Alkmin

; Atanes, Severiano Melo

; Pastore, Carlos Alberto

Arquivos Brasileiros de Cardiologia

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oct 2022, Volume 119 N. 4 Pages 638 - 680

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220623

12.

Microorganisms: the secret agents of the biosphere, and their key roles in biotechnology
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Oliveira, Valeria Maia

; Andreote, Fernando Dini

; Cortelo, Patricia Cardoso

; Castro-Gamboa, Ian

; Costa-Lotufo, Leticia V.

; Polizeli, Maria de Lourdes T. M.

; Thiemann, Otávio H.

; Setubal, João Carlos

Biota Neotropica

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2022, Volume 22 N. spe elocation e20221343

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Apresentamos um levantamento comentado de projetos financiados pelo programa BIOTA-Micro-organismos. Estes projetos geraram uma variada gama de resultados, incluindo a identificação de novos micro-organismos produtores de compostos antibacterianos, a caracterização de novas enzimas microbianas para usos industriais, classificação taxonômica de novos micro-organismos presentes em diversos ambientes, investigação de ecossistemas microbianos em solos e mangues e sua influência sobre plantas ameaçadas, e o sequenciamento de vários novos genomas microbianos derivados de metagenomas. Os resultados descritos demonstram o papel-chave de micro-organismos em ecossistemas importantes para atividades humanas, assim como o potencial que vários desses micro-organismos tem de contribuir para aplicações biotecnológicas cruciais para a sobrevivência humana no século 21.

Abstract We present a survey of projects that have been funded by FAPESP under the BIOTA-Microorganisms program. These projects generated a wide variety of results, including the identification of novel antibacterial-producing microorganisms, the characterization of novel microbial enzymes for industrial applications, taxonomic classification of novel microorganisms in several environments, investigation of the soil and mangrove microbial ecosystems and its influence on endangered plant species, and the sequencing of novel metagenome-assembled genomes. The results surveyed demonstrate the importance of microorganisms in environments that play important roles in human activities as well as the potential that many of these microorganisms have in contributing to biotechnological applications crucial for human survival in the 21st century.

https://doi.org/10.1590/1676-0611-bn-2022-1343

13.

Sazonalidade dos elementos do clima e sua influência na serapilheira em uma floresta sucessional na Amazônia oriental
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Machado-Lima, Juliana Cristina

; Andrade, Vanda Maria Sales de

; Braz-Homci, Valéria Pereira

; Cordeiro-Costa, Beatriz

; Suzuki, Patrícia Mie

; Souza, Wanessa Lisandra de Amorim e

; Santos, Mario Lima dos

; Assis-Oliveira, Francisco de

Revista Forestal Mesoamericana Kurú

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dec 2021, Volume 18 N. 43 Pages 62 - 70

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A produção e decomposição da serapilheira é importante no funcionamento e na dinâmica de um ecossistema florestal, associando variáveis climatológicas à biomassa. Com isso, investigou-se o estoque de serapilheira em função da sozanalidade dos elementos do clima em uma floresta sucessional na Amazônia oriental. O estudo foi conduzido em uma floresta sucessional, na Região Metropolitana de Belém (RMB), Pará. No ecossistema foi realizada uma amostragem aleatória em três transectos alocados ao longo da perpendicular da linha de borda de 50 m. A análise do efeito da sazonalidade dos elementos do clima nas propriedades físicas (volume, espessura, densidade e massa seca) e no carbono da serapilheira foram realizadas utilizando o teste t student e ANOVA do teste F a 5 % de significância. A precipitação (495,2±125 mm e 109,8±60 mm) e a umidade relativa do ar (89,0±1,7 % e 79,6±2,8 %) apresentaram diferença estatística na sazonalidade (p<0,05), diferente da temperatura (27,1±0,2 ºC e 27,6±0,3 ºC) que não houve diferença. As variáveis da serapilheira não foram influenciadas pela sazonalidade dos elementos do clima e não diferiram estatisticamente entre os períodos chuvoso e menos chuvoso, respectivamente: quantidade de serapilheira acumulada (16,46±4,17 Mg ha-1 e 13,91±7,61 Mg ha-1), estoque de carbono da serapilheira (7,9±2,0 Mg ha-1 e 6,6 ± 3,61 Mg ha-1), volume (26,21±0,92 cm3 e 24,88±0,92 cm3), espessura (4,19±0,92 cm e 3,99±0,95 cm) e densidade (0,041±0,92 g/cm3 e 0,034±0,92 g/cm3). A sazonalidade dos elementos do clima não apresentou variação considerável a ponto de alterar as propriedades físicas e o carbono da serapilheira.

Abstract The production and decomposition of litter is important in the functioning and dynamic of a forest ecosystem, associating climatological variables to biomass. With that, the litter stock was investigated due to the seasonality of the climate in a successional forest in eastern Amazon. The study was conducted in a successional forest, in the metropolitan region of Belém (RMB), Pará. In the ecosystem, a random sampling was performed in three transects located along the perpendicular of the 50m border line. The analysis of the effect of the seasonality of the elements of the climate on the litter physical properties (volume, thickness, density and dry mass) and carbon content were carried out using the t Student test and ANOVA of the F test at 5 % significance level. Precipitation (495.2 ± 125 mm and 109.8 ± 60 mm) and relative humidity (89.0 ± 1.7 % and 79.6 ± 2.8 %) showed a statistical difference in seasonality (p<0.05), different from the temperature (27.1 ± 0.2 ºC and 27.6 ± 0.3 ºC), there was no difference. The litter variables were not influenced by the seasonality of the elements of the climate and did not differ statistically between the rainy and less rainy periods, respectively: amount of accumulated litter (16.46 ± 4.17 Mg.ha-1 and 13.91 ± 7.61 Mg.ha-1), litter carbon stock (7.9 ± 2, 0 Mg.ha-1 and 6.6 ± 3.61 Mg.ha-1), volume (26.21 ± 0.92cm3 and 24.88 ± 0.92 cm3), thickness (4.19 ± 0.92 cm and 3.99 ± 0.95 cm) and density (0.041 ± 0.92 g/cm3 and 0.034 ± 0.92 g/cm3). The seasonality of the elements of the climate did not show considerable variation to the point of altering the litter physical properties and carbon content.

https://doi.org/10.18845/rfmk.v19i43.5810

14.

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

15.

O Teste de Caminhada de 6 Minutos prevê a melhora física em longo prazo de sobreviventes à unidade de terapia intensiva: um estudo de coorte prospectiva
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Rosa, Regis Goulart

; Dietrich, Camila

; Valle, Enio Luiz Tschiedel do

; Souza, Denise

; Tagliari, Luciana

; Mattioni, Mariana

; Tonietto, Túlio Frederico

; Rosa, Rosa da

; Barbosa, Mirceli Goulart

; Lovatel, Gisele Agustini

; Lago, Pedro Dal

; Oliveira, Eubrando Silvestre

; Sganzerla, Daniel

; Andrade, Juliana M. S.

; Berto, Paula

; Cardoso, Paulo Ricardo

; Sanchez, Evelin Carneiro

; Falavigna, Maicon

; Maccari, Juçara G.

; Rech, Gabriela

; Robinson, Caroline

; Schneider, Daniel

; Leon, Patrícia de

; Biason, Lívia

; Teixeira, Cassiano

Revista Brasileira de Terapia Intensiva

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sep 2021, Volume 33 N. 3 Pages 374 - 383

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a capacidade do Teste de Caminhada de 6 Minutos para predizer a melhora do estado funcional físico em longo prazo de pacientes sobreviventes à unidade de terapia intensiva. Métodos: Foram avaliados, de forma prospectiva, entre fevereiro de 2017 e agosto de 2018, em um ambulatório pós-unidade de terapia intensiva, 32 sobreviventes à unidade de terapia intensiva. Foram inscritos consecutivamente os pacientes com permanência na unidade de terapia intensiva acima de 72 horas (para admissões emergenciais) ou acima de 120 horas (para admissões eletivas) que compareceram ao ambulatório pós-unidade de terapia intensiva 4 meses após receberem alta da unidade de terapia intensiva. A associação entre a distância percorrida no Teste de Caminhada de 6 Minutos realizado na avaliação inicial e a evolução do estado funcional físico foi avaliada durante 8 meses, com utilização do Índice de Barthel. Resultados: A distância média percorrida no Teste de Caminhada de 6 Minutos foi significantemente mais baixa nos sobreviventes à unidade de terapia intensiva do que na população geral (405m versus 557m; p < 0,001). A idade (β = -4,0; p < 0,001) e a fraqueza muscular (β = -99,7; p = 0,02) se associaram com a distância percorrida no Teste de Caminhada de 6 Minutos. A distância percorrida no Teste de Caminhada de 6 Minutos se associou com melhora do estado funcional físico no período de 8 meses de acompanhamento desses pacientes (razão de chance para cada 10m: 1,07; IC95% 1,01 - 1,16; p = 0,03). A área sob a curva Característica de Operação do Receptor para predição da melhora funcional física pelo Teste de Caminhada de 6 Minutos foi de 0,72 (IC95% 0,53 - 0,88). Conclusão: O Teste de Caminhada de 6 Minutos, realizado 4 meses após a alta da unidade de terapia intensiva, predisse com precisão moderada a melhora do estado funcional físico de sobreviventes à unidade de terapia intensiva.

ABSTRACT Objective: To evaluate the ability of the 6-Minute Walk Test to predict long-term physical functional status improvement among intensive care unit survivors. Methods: Thirty-two intensive care unit survivors were prospectively evaluated from February 2017 to August 2018 in a post-intensive care unit outpatient clinic in Brazil. Individuals with intensive care unit stays > 72 hours (emergency admissions) or > 120 hours (elective admissions) attending the post-intensive care unit clinic four months after intensive care unit discharge were consecutively enrolled. The association between the 6-Minute Walk Test distance at baseline and physical functional status was assessed over 8 months using the Barthel Index. Results: The mean 6-Minute Walk Test distance was significantly lower in intensive care unit survivors than in the general population (405m versus 557m; p < 0.001). Age (β = -4.0; p < 0.001) and muscle weakness (β = -99.7; p = 0.02) were associated with the 6-Minute Walk Test distance. A 6-Minute Walk Test distance was associated with improvement in physical functional status over the 8-month follow-up (odds ratio for each 10m of 1.07; 95%CI 1.01 - 1.16; p = 0.03). The area under the Receiver Operating Characteristic curve for the 6-Minute Walk Test prediction of physical functional status improvement was 0.72 (95%CI 0.53 - 0.88). Conclusion: The 6-Minute Walk Test performed 4 months after intensive care unit discharge predicted long-term physical functional status among intensive care unit survivors with moderate accuracy.

https://doi.org/10.5935/0103-507x.20210056 132 downloads

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