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ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

The role of primary inguinal surgical debulking for locally advanced penile cancer followed by reconstruction with myocutaneous flap
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Koifman, Leandro

; Hampl, Daniel

; Ginsberg, Marcio

; Castro, Rodrigo Barros de

; Koifman, Nelson

; Ornellas, Paulo

; Ornellas, Antonio Augusto

International braz j urol

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dec 2021, Volume 47 N. 6 Pages 1162 - 1175

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate surgical complications and oncological outcomes of patients submitted to primary radical inguinal surgical debulking (PRISD) and myocutaneous pediculate flap reconstruction (MPFR) for locally advanced penile cancer (PC). Materials and Methods: Forty-two patients with ulcerated and/or fixed bulky inguinal masses underwent unilateral or bilateral PRISD with MPFR. Tensor fascia lata flap (TFL) was the standard of care for all patients. Additional use of the gracilis flap (GF) was carried out when necessary. Contra-lateral radical inguinal lymphadenectomy (RIL) was conduced when PRISD was performed unilaterally. Surgical complications were analyzed and stratified into minor and major according to the Bevan-Thomas classification. Adjunctive treatments were assessed and oncological outcomes analyzed. Results: Of the 42 patients evaluated, 10 (23.8%) underwent bilateral PRISD and 32 (76.2%) unilateral PRISD with contra-lateral RIL, totaling 84 lymphadenectomies. A total of 62 MPFRs were performed, 52 with TFL and 10 with GF. A total of 53 complications were identified, 49 related to PRISD with MPFR and 4 to RIL. Adjuvant chemotherapy was carried out in 16 patients. Median follow-up was 10.8 months with a median overall survival (OS) of 14.0 months against 6.0 months (p=0.006) for patients submitted to PRISD with adjuvant chemotherapy in relation to surgery alone. Conclusions: PRISD alone for advanced loco-regional PC is unlikely to promote long-term survival, although it can lead to temporary local control of the disease. Despite the feasibility of the procedure, it is related to high incidence of complications. Surgical treatment with adjuvant chemotherapy is associated with improved OS.

https://doi.org/10.1590/s1677-5538.ibju.2021.0169 85 downloads

Total mercury in wild felids occurring in protected areas in the central Brazilian Amazon
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LOPES, Marcelly Castello Branco

; CARVALHO, Gabriel Oliveira de

; BERNARDO, Robson Roney

; MACEDO, Joana

; LINO, Adan Santos

; RAMALHO, Emiliano Esterci

; KASPER, Daniele

; MEIRE, Rodrigo Ornellas

; TORRES, João Paulo Machado

; MALM, Olaf

Acta Amazonica

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jun 2020, Volume 50 N. 2 Pages 142 - 148

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este é o primeiro estudo a investigar a contaminação por mercúrio (Hg) em espécies de felinos na Amazônia brasileira. Foram coletadas 26 amostras de pelo de felinos selvagens de quatro espécies (Puma concolor, Panthera onca, Leopardus pardalis e Leopardus wiedii) ocorrendo nas reservas de desenvolvimento sustentável Mamirauá e Amanã, no estado do Amazonas. As amostras foram coletadas de espécimes de museu, exceto cinco amostras de P. onca obtidas de indivíduos capturados em vida livre. As concentrações de Hg variaram de 0,12 a 48,1 µg g-1. Não houve diferença significativa entre a concentração de Hg no pelo de espécimes de museu e de indivíduos vivos de P. onca. Houve variação significativa entre espécies, sendo que P. onca e L. pardalis tiveram concentrações significativamente mais altas, o que pode estar relacionado a fatores como dieta e hábitat.

ABSTRACT This is the first study to investigate mercury (Hg) contamination in felid species in the Brazilian Amazon. We collected 26 fur samples from wild felids of four species (Puma concolor, Panthera onca, Leopardus pardalis and Leopardus wiedii) occurring in the Mamirauá and Amanã sustainable development reserves, in the state of Amazonas. Samples were from museum specimens, except for five P. onca samples collected from free-living individuals. Total Hg concentrations ranged from 0.12 to 48.1 µg g-1. Concentrations of Hg did not differ significantly between museum specimens and live individuals of P. onca, but varied significantly among species, with significantly higher concentrations for P. onca and L. pardalis, which could be related to factors such as diet and habitat.

https://doi.org/10.1590/1809-4392201903331 1325 downloads

Treatment Options and Outcomes of Penile Constriction Devices
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Koifman, Leandro

; Hampl, Daniel

; Silva, Maria Isabel

; Pessoa, Paulo Gabriel Antunes

; Ornellas, Antonio Augusto

; Barros, Rodrigo

International braz j urol

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apr 2019, Volume 45 N. 2 Pages 384 - 391

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To study the effect of penile constriction devices used on a large series of patients who presented at our emergency facility. We explored treatment options to prevent a wide range of vascular and mechanical injuries occurring due to penile entrapment. Materials and Methods: Between January 2001 and March 2016, 26 patients with penile entrapment were admitted to our facility and prospectively evaluated. Results: The time that elapsed from penile constrictor application to hospital admission varied from 10 hours to 6 weeks (mean: 22.8 hours). Non-metallic devices were used by 18 patients (66.6%) while the other nine (33.4%) had used metallic objects. Acute urinary retention was present in six (23%) patients, of whom four (66.6%) underwent percutaneous surgical cystotomy and two (33.4%) underwent simple bladder catheterization. The main reason for penile constrictor placement was erectile dysfunction, accounting for 15 (55.5%) cases. Autoerotic intention, psychiatric disorders, and sexual violence were responsible in five (18.5%), five (18.5%), and two (7.4%) cases, respectively. The mean hospital stay was 18 hours (range, 6 hours to 3 weeks). Conclusion: Penile strangulation treatment must be immediate through the extraction of the foreign body, avoiding vascular impairments that can lead to serious complications. Most patients present with low-grade injuries and use penile constrictors due to erectile dysfunction. Removal of constrictor device can be challenging. The use of specific tools for achieving penile release from constrictors is a fast, safe and effective method. Patients with urinary retention may require urinary diversion.

https://doi.org/10.1590/s1677-5538.ibju.2018.0667 1044 downloads

Corrupção urbanística em sistemas de planejamento e gestão urbanos: um estudo de caso
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Borges, Leonardo Beraldo de Ornellas

; Silva, Jonathas Magalhães Pereira da

urbe. Revista Brasileira de Gestão Urbana

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2019, Volume 11 elocation e20180056

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O presente trabalho problematiza as dificuldades encontradas na gestão urbana relacionadas à corrupção urbanística, isto é, ações com protagonismo de agentes públicos e privados que se utilizam do sistema de planejamento para o benefício próprio ou de um determinado grupo. Investigam-se mecanismos que, inseridos nos sistemas de planejamento, podem potencializar transações corruptas, por meio de uma revisão da literatura que trata da corrupção urbanística, busca delinear quais elementos contribuiriam para esta dinâmica. Para isso, o trabalho foi estruturado a partir de um estudo de caso, que analisou a dinâmica de um sistema de planejamento e gestão em um município paulista durante o intervalo de 1985-2016. Os dados levantados, de metodologia analítica qualitativo, baseada em documentos oficiais como: processos jurídicos, legislação urbanística, assim como notícias veiculadas no período, possibilitam a identificação dos atores participantes nos processos de expansão urbana no período. O estudo de caso dialoga com elementos encontrados na literatura que permitem a construção de um método de trabalho que estabelece suas categorias de analises formadas por fatores indutores da corrupção urbanística como: a alta discricionariedade, a opacidade procedimental e o direcionamento normativo. Assim, este estudo apresenta de que forma determinados mecanismos auxiliaram na obtenção de privilégios nestes processos.

Abstract This paper seeks to assist in the understanding of the difficulties found in urban management related to urban corruption, defined by actions with protagonist of public and private agents who use the planning system for their own benefit or for a particular group. Some mechanisms are investigated that, inserted in the planning systems, can potentiate corrupt transactions. Through a literature review dealing with urban corruption, it seeks to outline which elements would contribute to this dynamic. The work was structured through a case study, which analyzed the dynamics of a planning and management system in a city of São Paulo during the period 1985-2016. The data collected, using a qualitative analytical method, based on official documents such as: legal processes, urban legislation and newspapers in the period, which allow the identification of the actors involved in the processes of urban expansion in the period. The case study dialogues with elements found in the literature allowing the construction of a work method that establishes its categories of analysis formed by factors inducing urban corruption such as: high discretion, procedural opacity and normative direction. The paper presents how certain mechanisms helped to obtain privileges in these processes.

https://doi.org/10.1590/2175-3369.011.002.ao06 1387 downloads

HPV vaccination is fundamental for reducing or erradicate penile cancer | Opinion: NO
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Ornellas, Paulo

; Ornellas, Antonio Augusto

International braz j urol

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oct 2018, Volume 44 N. 5 Pages 862 - 864

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/s1677-5538.ibju.2018.05.03 961 downloads

Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report
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Ornellas, Maria Helena Faria

; Maioli, Maria Christina Paixão

; Lucena, Stella Beatriz Sampaio Gonçalves de

; Bastos, Elenice Ferreira

; Chaves, Tatiana Silva

; Melo, Karina Vieira de

; Ribeiro-Carvalho, Marilza de Moura

; Liehr, Thomas

; Alves, Gilda

Sao Paulo Medical Journal

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aug 2018, Volume 136 N. 4 Pages 361 - 367

Abstract: En | Text: En | PDF: En

ABSTRACT CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSIONS: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.

https://doi.org/10.1590/1516-3180.2016.0252150217 912 downloads

Sexual complications of penile frature in men who have sex with men
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Barros, Rodrigo

; Lacerda, Gabriel

; Schul, Alex

; Ornellas, Paulo

; Koifman, Leandro

; Favorito, Luciano A.

International braz j urol

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jun 2018, Volume 44 N. 3 Pages 550 - 554

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: Evaluate the demographic data, etiology, operative findings and results of surgical treatment of penile fracture (PF) in men who have sex with men(MSM) with emphasis on sexual complications. Materials and Methods: We studied 216 patients underwent surgical correction of PF at our hospital. Patients self-identified as MSM were followed for at least 6 months. Demographic data, presentation, operative findings, International Index of Erection Function - 5 (IIEF-5) and the Premature Ejaculation Diagnostic Tool. Results: Of 216 PF cases, 4 (1.8%) were MSM. All cases resulted from sexual activity and all patients reported using the “doggy style” position during anal intercourse. Unilateral or bilateral injury of corpus cavernosum was found in 2 patients each. One (25%) patient had complete urethral injury associated with bilateral corpus cavernosum lesion. During the follow-up period, all patients developed some type of sexual complication. One patient reported penile pain during intercourse. Another patient experienced low sexual desire and premature ejaculation. This patient was also dissatisfied with the aesthetic result of the surgical scar and complained about decreased penis size after surgery. The third case developed delayed ejaculation. The fourth patient experienced mild to moderate erectile dysfunction. This same patient presented with penile curvature. Finally, palpable fibrotic nodules in the operative area were observed in all cases. Conclusions: Sexual activity in the “doggy style” position was the commonest cause of PF in MSM. Sexual dysfunction is always present in gay man after surgery for PF. However, additional studies with larger samples should be coinducted.

https://doi.org/10.1590/s1677-5538.ibju.2017.0520 1721 downloads

O cuidado em saúde mental na atenção básica: uma cartografia
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Santana, Taís Fernanda Maimoni Contieri

; Pereira, Maria Alice Ornellas

Revista Enfermagem UERJ

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2018, Volume 26 elocation e32305

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective to map the daily care of patients with psychic disorders, the subjects of the mapping being the personnel of a family health unit and a family health support unit. Method nine health professionals participated in this qualitative study in northwest São Paulo in mid-2013. Data were collected by case study, field diary, semi-structured interview and analytical flowchart. The project was approved by the research ethics committee. Results results were captured and structured in three territories, of which the territory of doing was presented in this study. These evidenced the difficulties facing possible reversal of care, which is still based on the hegemonic medical model. Conclusion there were obstacles to effective bonding, accountability and commitment by these professionals, making it hard to envisage advances in daily mental health practice, which hinders psychosocial rehabilitation.

RESUMEN Objetivo cartografiar el cotidiano del cuidado al portador del trastorno psíquico, los sujetos siendo los profesionales de una unidad de la salud de la familia, así como los de un núcleo de apoyo a la salud de la familia. Método investigación de naturaleza cualitativa, con la participación de nueve profesionales, del noroeste de São Paulo, a mediados de 2013. Para la recolección de datos se utilizó el estudio de caso, el diario de campo, la entrevista semiestructurada y el diagrama de flujo analizador. El proyecto fue aprobado por el Comité de Ética en Investigación. Resultados fueron delimitados y estructurados en tres territorios, siendo que, en este estudio, se presentó el territorio del hacer. Se evidenciaron dificultades en cuanto a la posibilidad de reversión del cuidado, con base aún en el modelo médico hegemónico. Conclusión hubo obstáculos en cuanto a volver efectivos el vínculo, la responsabilidad y el comprometimiento por parte de esos profesionales para poder vislumbrar avances en el cotidiano de las prácticas en la salud mental, lo que dificulta la rehabilitación psicosocial.

RESUMO Objetivo cartografar o cotidiano do cuidado ao portador de transtorno psíquico, tendo como sujeitos os profissionais de uma unidade de saúde da família, bem como os de um núcleo de apoio à saúde da família. Método investigação de natureza qualitativa, com participação de nove profissionais, do noroeste paulista em meados de 2013. Utilizou-se para coleta de dados o estudo de caso, o diário de campo, a entrevista semiestruturada e o fluxograma analisador. O projeto foi aprovado por Comitê de Ética em Pesquisa. Resultados foram apreendidos e estruturados em três territórios, sendo, neste estudo, apresentado o território do fazer; evidenciaram-se dificuldades à possibilidade da reversão do cuidado, este embasado, ainda, no modelo médico hegemônico. Conclusão houve entraves para a efetivação do vínculo, da responsabilização e do comprometimento desses profissionais para vislumbrarem avanços no cotidiano das práticas em saúde mental, o que dificulta a reabilitação psicossocial.

https://doi.org/10.12957/reuerj.2018.32305 11 downloads

10.

Diagnóstico e fatores de risco do complexo teníase-cisticercose bovina no município de Salinas, Minas Gerais
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Magalhães, Fernanda C.

; Santos, Thiago M.

; Assis, Débora C.

; Ornellas, Cleia D.

; Pinto, Paulo A.

; Santos, Wagner M.

Pesquisa Veterinária Brasileira

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mar 2017, Volume 37 N. 3 Pages 205 - 209

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Com o objetivo de diagnosticar a situação do complexo teníase-cisticercose bovina no município de Salinas, Minas Gerais, foram coletadas amostras de sangue de 355 bovinos distribuídos em 18 propriedades rurais, sorteadas aleatoriamente. Em cada propriedade, foi aplicado um questionário socioeconômico para a análise de fatores que favorecem a manutenção do complexo teníase-cisticercose bovina. Foi realizado também um levantamento epidemiológico dos casos de teníase diagnosticados nos laboratórios credenciados pela Secretaria Municipal de Saúde de Salinas, no período de 2007 a 2010. A prevalência de cisticercose bovina foi de 4,70% enquanto as prevalências de teníase, encontradas durante os quatro períodos avaliados, foram de 0,29%, 0,36%, 0,24% e 0,24%. Entre os fatores de risco para a manutenção do complexo teníase-cisticercose analisados, foi observada uma relação estatisticamente significativa entre a ocorrência de cisticercose bovina e a ingestão de carne malpassada pelos entrevistados. Foi concluído que a cisticercose bovina está presente no município de Salinas, Minas Gerais, sendo o tratamento térmico ineficiente da carne bovina o principal fator de risco para a manutenção do complexo teníase-cisticercose, o que reforça a necessidade da adoção de medidas de controle com contínua vigilância epidemiológica e sanitária.

ABSTRACT: In order to diagnose the situation of bovine taeniasis-cysticercosis complex in the municipality of Salinas, Minas Gerais, Brazil, blood samples were collected from 355 cattle in 18 randomly selected farms. A socioeconomic questionnaire was filled in each farm for the analysis of factors which favor the maintenance of the taeniasis-cysticercosis complex. An epidemiological survey of human taeniasis was performed through analyses of the Municipal Health Department in the 2007-2010 period. A prevalence of 4.7% for bovine cysticercosis and the frequency of 0.29, 0.36, 0.24 and 0.24% for human taeniasis, during the evaluated period, was found. Among the risk factors, a statistically significant correlation was found between the occurrence of bovine cysticercosis and the ingestion of undercooked meat. It was concluded that bovine cysticercosis is present in the municipality of Salinas, due to inefficient heat treatment of the meat as the main risk factor for maintenance of the taeniasis-cysticercosis complex, reinforcing the need to adopt control measures with continuous epidemiological and health surveillance.

https://doi.org/10.1590/s0100-736x2017000300001 10447 downloads

11.

Should routine neonatal circumcision be a police to prevent penile cancer? | Opinion: Yes
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Ornellas, Antonio Augusto

; Ornellas, Paulo

International braz j urol

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feb 2017, Volume 43 N. 1 Pages 7 - 9

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/s1677-5538.ibju.2017.01.03 1309 downloads

12.

Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus
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Koifman, Leandro

; Ornellas, Paulo

; Ornellas, Antonio Augusto

; Pereira, Denise de Abreu

; Zingali, Benedeta Russolina

; Cavalcanti, Silvia Maria Baeta

; Afonso, Larissa Alves

; Sandim, Vanessa

; Alves, Gilda

International braz j urol

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aug 2015, Volume 41 N. 4 Pages 642 - 654

Abstract: En | Text: En | PDF: En

ABSTRACTPurpose:The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials and Methods:Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients.

https://doi.org/10.1590/S1677-5538.IBJU.2014.0051 1697 downloads

13.

Characterizing new molecular species: a systematic study of stationary states on the singlet [H, Se, Br] potential energy surface
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Hermoso, Willian

; Morf, Debora B.

; Ornellas, Fernando R.

Journal of the Brazilian Chemical Society

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jun 2013, Volume 24 N. 6 Pages 1049 - 1056

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Usando um alto nível de teoria, CCSD(T)/CBS, investigou-se a estrutura, o espectro no infravermelho, a estabilidade relativa, as energias de dissociação e a barreira energética para a interconversão de novas espécies moleculares, HSeBr e HBrSe. Previu-se a molécula HSeBr mais estável por 44,95 kcal mol-1 que HBrSe, com uma barreira (ΔG#) para a isomerização de 52,24 kcal mol-1. Pelo fato da barreira para a reação reversa ser bem menor que a do processo direto, espera-se que o isômero menos estável, caso venha a ser formado, seja prontamente convertido em HSeBr, exceto a temperaturas criogênicas. A possibilidade de dissociação em Se e HBr é também provável por um mecanismo de acoplamento spin-órbita. Calores de formação a 298,15 K para SeBr e HSeBr foram estimados como sendo 31,54 e 12,31 kcal mol-1, respectivamente. Estimou-se ainda o efeito da inclusão do efeito da correlação caroço-valência nos parâmetros estruturais e nas frequências, como também a contribuição da anarmonicidade nas frequências. Cálculos adicionais realizados com funções de onda explicitamente correlacionadas mostraram resultados bastante promissores de convergência mais rápida para o limite de base completa (CBS) com bases relativamente bem menores.

Structural characterization, infrared spectra, relative stability, dissociation energies and energy barrier for isomerization of new molecular species, HSeBr and HBrSe, were investigated at a high level of theory, CCSD(T)/CBS. HSeBr is predicted to be 44.95 kcal mol-1 more stable than HBrSe, with a barrier (ΔG#) for isomerization of 52.24 kcal mol-1. Due to the much smaller barrier for the reverse reaction, if formed, the less stable isomer is expected to be readily converted to HSeBr, except at cryogenic temperatures. The possibility of dissociation into atomic Se and HBr is also a likely one by a spin-orbit coupling mechanism. Heats of formation of SeBr and HSeBr were estimated to be 31.54 and 12.31 kcal mol-1, respectively, at 298.15 K. The effect of core-valence correlation on the structural parameters and harmonic frequencies was also evaluated, as well as the contribution of anharmonicity to the frequencies. Additional calculations performed with explicitly correlated wavefunctions showed promising results of fast convergence to the complete basis set (CBS) limit with relatively smaller basis sets.

https://doi.org/10.5935/0103-5053.20130135 1093 downloads

14.

Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis
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Ornellas, Paulo

; Ornellas, Antonio Augusto

; Chinello, Clizia

; Gianazza, Erica

; Mainini, Veronica

; Cazzaniga, Marta

; Pereira, Denise Abreu

; Sandim, Vanessa

; Cypriano, Ana Sheila

; Koifman, Leandro

; Silva, Paulo Cesar Barbosa da

; Alves, Gilda

; Magni, Fulvio

International braz j urol

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dec 2012, Volume 38 N. 6 Pages 739 - 749

Abstract: En | Text: En | PDF: En

PurposeTo investigate the use of ClinProt technique to identify cancer markers in plasma of patients suffering from squamous cell carcinoma of the penis (SCCP).Materials and MethodsPlasma of 36 healthy subjects and 25 patients with penile carcinoma who underwent surgical treatment between June 2010 and June 2011 was collected and analyzed by the ClinProt/MALDI/ToF technique. Then the peptides were identified from the C8 MB eluted fraction of patients' and control subjects' plasma by LIFT MS/MS.ResultsA cluster of 2 peptides (A=m/z 1897.22 ± 9 Da and B=m/z 2021.99 ± 9 Da) was able to discriminate patients from control subjects. Cross validation analysis using the whole casuistic showed 62.5% and 86.76% sensitivity and specificity, respectively. The cluster also showed very high sensitivity (100%) and specificity (97%) for SCCP patients that died due to the disease. Furthermore, patients with lymph node involvement presented sensitivity and specificity of 80% and 97%, respectively. These two peptides were identified by the proteomic approach based on a MALDI-TOF/TOF as fragments of C3 (m/z 1896.17) and C4a/b (m/z 2021.26) complement proteins.ConclusionsThe results showed that as the disease progresses, the fragments C3 and C4 A/B are less expressed in comparison with healthy subjects. These results may be useful as prognostic tools.

https://doi.org/10.1590/1677-553820133806739 2714 downloads Cited 1 time in SciELO

15.

Prognostic factors in renal cell carcinoma: analysis of 227 patients treated at the Brazilian National Cancer Institute
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Ornellas, Antonio A.

; Andrade, Dennyson M.

; Ornellas, Paulo

; Wisnescky, Aristóteles

; Schwindt, Aline B. de Santos

International braz j urol

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apr 2012, Volume 38 N. 2 Pages 185 - 194

Abstract: En | Text: En | PDF: En

PURPOSE: We evaluated the role of several prognostic factors in predicting death and/or progressive disease in patients with renal cell carcinoma. MATERIALS AND METHODS: Between 2004 and 2010, 227 consecutive patients with renal cell carcinoma underwent radical nephrectomy at our Institute. All histological specimens were examined by the same pathologist. We considered certain histological parameters, including histological subtype, conventional Fuhrman grade, presence of sarcomatoid features, adrenal gland infiltration, invasion of the perinephric fat, vascular embolization, collecting system invasion, presence or absence of tumour necrosis (0%, 1% to 49%, or 50% or greater) and regional lymph node metastasis. RESULTS: Variables significantly associated with death and/or progressive disease on univariate analysis were histological subtype (p = 0.006), Fuhrman grade (p < 0.0001), tumor necrosis (p = 0.009), perinephric fat invasion (p = 0.002), vascular embolization (p = 0.0002), presence of lymph node involvement (p < 0.002), tumor size (p = 0.0006), TNM stage (p < 0.00001) and presence of metastasis (p < 0.00001). In the multivariable model histological subtype, tumor necrosis, lymph node involvement and presence of metastasis were independent risk factors for disease-free survival (p = 0.011, 0.042, 0.025 and p < 0.0001, respectively). CONCLUSION: Histological subtype, tumor necrosis, lymph node involvement and presence of metastasis proved to be independent prognostic factors for disease-free survival. Therefore, the presence and rate of tumor necrosis should always be informed by the pathologist and lymphadenectomy should be performed in all patients.

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