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ABSTRACT The covid-19 vaccine confers direct protection and reduces transmission rates of the virus and new variants. Vaccines from Pfizer/BioNTech and CoronaVac have been cleared for children in Brazil. They are safe, effective, and immunogenic. There are no known complications associated with the use of steroids or vaccines in pediatric patients with covid-19 and nephrotic syndrome. With or without immunosuppression, these patients are not at increased risk of severe covid-19, and steroids are safe for them. A milder form of covid-19 occurs in patients with chronic kidney disease without the need for hospitalization. The vaccine response may be reduced and/or the duration of antibodies after vaccination may be shorter than in the general population. However, considering risk of exposure, vaccination against covid-19 is recommended. It is believed that patients with hemolytic-uremic syndrome are at higher risk of severe covid-19. Vaccination is recommended, although specific data on the safety and efficacy of the covid-19 vaccine are limited. There is agreement that the benefits of induced immunity outweigh the risks of immunization. Vaccination against covid-19 is recommended for children and adolescents needing kidney transplantation or who have undergone transplantation. These patients present decreased immune response after vaccination, but immunization is recommended because the benefits outweigh the risks of vaccination. Current recommendations in Brazil stipulate the use of the messenger RNA vaccine. This paper aims to provide pediatric nephrologists with the latest knowledge about vaccination against covid-19 for children with kidney disease.

Resumo A vacina covid-19 confere proteção direta, reduz as taxas de transmissão do vírus e de novas variantes. No Brasil, estão liberadas para a população pediátrica as vacinas Pfizer/BioNTech e a CoronaVac, ambas seguras, eficazes e imunogênicas. Pacientes pediátricos com síndrome nefrótica e covid-19 têm curso clínico regular sem complicações relacionadas ao uso de esteroides ou vacinas. Esses pacientes, com ou sem imunossupressão, não apresentam maior risco de covid-19 grave e o tratamento com esteroides é seguro. Os pacientes com doença renal crônica têm covid-19 mais leve, sem necessidade de hospitalização. A resposta vacinal pode ser reduzida e/ou a duração dos anticorpos pós-vacinação pode ser menor do que na população geral. Entretanto, a vacina covid-19 está recomendada, considerando o risco de exposição. Acredita-se que pacientes com síndrome hemolítico-urêmica teriam maior risco de covid-19 grave. A vacina é recomendada, embora dados específicos sobre segurança e eficácia da vacina covid-19 sejam limitados. Há concordância que os benefícios da imunidade induzida superam quaisquer riscos da imunização. A vacina covid-19 é recomendada para crianças e adolescentes candidatos ao transplante renal ou já transplantados. Esses pacientes têm resposta imunológica reduzida após a vacina, entretanto ela é recomendada porque os benefícios superam qualquer risco dessa vacinação. A recomendação atual no Brasil é a vacina de tecnologia RNA mensageiro. O objetivo deste documento é levar aos nefrologistas pediátricos os conhecimentos mais recentes sobre a vacinação contra contra-19 em crianças com doenças renais.

https://doi.org/10.1590/2175-8239-jbn-2022-0081en

Pediatric peritoneal dialysis in Brazil: a discussion about sustainability. A document by the Brazilian Society of Nephrology, the Brazilian Society of Pediatrics, the Brazilian Association of Organ Transplantation, and the Brazilian Association of Dialysis and Transplant Centers
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Palma, Lilian Monteiro Pereira

; Penido, Maria Goretti Moreira Guimarães

; Bresolin, Nilzete Liberato

; Tavares, Marcelo de Sousa

; Sylvestre, Lucimary

; Andrade, Olberes Vitor Braga de

; Bernardes, Rejane de Paula

; Bandeira, Maria de Fátima Santos

; Garcia, Clotilde Druck

; Koch, Vera Hermina Kalika

; Belangero, Vera Maria Santoro

; Uhlmann, Anelise

; Soeiro, Emília Maria Dantas

; Kaufman, Arnauld

; Andrade, Maria Cristina de

; Silva, Roxana de Almeida Roque Fontes

; Calice-Silva, Viviani

; Vieira, Marcos Alexandre

; Merege Neto, Osvaldo Vieira

Brazilian Journal of Nephrology

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dec 2022, Volume 44 N. 4 Pages 579 - 584

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introdução: A diálise peritoneal (DP) é importante para a pediatria. Este estudo mostrou dados de centros brasileiros que utilizam DP pediátrica. Método: Estudo transversal, observacional, descritivo com questionário eletrônico. Incluiu-se pacientes de 0-18 anos em DP cadastrados nos bancos de dados dos diversos centros. Questionário preenchido anonimamente, sem dados de identificação. Foi adotada metodologia quantitativa. Resultados: 212 pacientes estão em DP no Brasil (agosto, 2021). 80% têm menos de 12 anos de idade. A maioria realiza DP automatizada e 74% são dependentes do Sistema Único de Saúde. Em 25% dos centros faltou material de DP e em 51% os pacientes pediátricos foram convertidos de DP para HD. Conclusão: A maioria dos pacientes tinha menos de 12 anos e era dependente do SUS. A escassez de insumos aconteceu em 25% dos centros. Esses dados apontam para o problema da sustentabilidade de DP, única alternativa de TRS em crianças muito pequenas.

Resumo Introdução: A diálise peritoneal (DP) é importante para a pediatria. Este estudo mostrou dados de centros brasileiros que utilizam DP pediátrica. Método: Estudo transversal, observacional, descritivo com questionário eletrônico. Incluiu-se pacientes de 0-18 anos em DP cadastrados nos bancos de dados dos diversos centros. Questionário preenchido anonimamente, sem dados de identificação. Foi adotada metodologia quantitativa. Resultados: 212 pacientes estão em DP no Brasil (agosto, 2021). 80% têm menos de 12 anos de idade. A maioria realiza DP automatizada e 74% são dependentes do Sistema Único de Saúde. Em 25% dos centros faltou material de DP e em 51% os pacientes pediátricos foram convertidos de DP para HD. Conclusão: A maioria dos pacientes tinha menos de 12 anos e era dependente do SUS. A escassez de insumos aconteceu em 25% dos centros. Esses dados apontam para o problema da sustentabilidade de DP, única alternativa de TRS em crianças muito pequenas.

https://doi.org/10.1590/2175-8239-jbn-2021-0245

[SciELO Preprints] - Diagnosis and comprehensive management of odontogenic sinusitis. A systematic review
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Muñoz, Brenda Palma, Matias Quintanilla, Fernanda Bustos, Vera

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Publication date: 2022-11-11

Abstract: En Es

Odontogenic sinusitis has a high prevalence within the pathologies of the maxillary sinus, due to the proximity of the roots of the antral teeth to the floor of the maxillary sinus and their common vascularization. The diagnosis and treatment are parameters that have been arduously investigated, however there is no established clinical consensus on its most appropriate management. Therefore, the objective of this systematic review without meta-analysis is to develop a clinical recommendation based on available and updated evidence on the diagnosis and management of odontogenic sinusitis using the GRADE approach to determinate the certainty level for the recommendations, this will contribute to making appropriate decisions for patients with this pathology. The database examined was Medline via Pubmed using search criteria based on the PICO question including studies with a data of 10 years, the selection of studies was carried out independently by three researchers through the RAYYAN platform. The results of the 15 studies carried out showed, one study of very high quality, six of high quality, four of moderate quality, one of low quality, three of very low quality. Regarding the GRADE analysis, four recommendations for diagnosis and four for treatment, contributing to a correct management of odontogenic sinusitis. Finally, it is concluded that cone beam computed tomography is the gold standard for diagnosis and its treatment requires multidisciplinary management.

La sinusitis odontogénica tiene una alta prevalencia dentro de las patologías del seno maxilar, debido a la proximidad de las raíces de los dientes antrales con el piso del seno maxilar y su vascularización en común. Su diagnóstico y tratamiento son parámetros arduamente investigados, sin embargo, no hay un consenso clínico establecido sobre su manejo más adecuado. Por ello, el objetivo de esta revisión sistemática sin metaanálisis es elaborar una recomendación clínica en base a evidencia disponible y actualizada sobre diagnóstico y manejo de sinusitis odontogénica usando el enfoque GRADE para determinar el nivel de certeza de la evidencia para las recomendaciones; esto contribuirá en una toma de decisiones adecuada para los pacientes con dicha patología. La base de datos examinada fue Medline vía Pubmed utilizando criterios de búsqueda basados en la pregunta PICO incluyendo estudios de una data máxima de diez años. La selección de estudios fue realizada de manera independiente por los investigadores mediante la plataforma RAYYAN. En los resultados de los 15 estudios analizados se evidenciaron, un estudio de calidad muy alta, seis de calidad alta, cuatro de calidad moderada, uno de calidad baja, tres de calidad muy baja. En cuanto al análisis GRADE, cuatro recomendaciones para diagnóstico y cuatro para tratamiento, contribuyendo a un correcto manejo de la sinusitis odontogénica. Por último, se concluye que la tomografía computarizada de haz cónico el Gold estándar de diagnóstico y su tratamiento requiere de un manejo multidisciplinario.

https://doi.org/10.1590/SciELOPreprints.5008

Púrpura de Schönlein Henoch en paciente adulto
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Vera Franco, Víctor Jonathan

; Alvarado, Daniel Andrés

; Montero Mendoza, Moisés Adrián

; García Pacheco, Andrea Verónica

; Cáceres Palma, María Lorena

; Gaibor Pacheco, Betzy Elizabeth

Revista Virtual de la Sociedad Paraguaya de Medicina Interna

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sep 2022, Volume 9 N. 2 Pages 153 - 159

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN La púrpura de Schönlein-Henoch es una vasculitis por fragmentación de leucocitos inmunomediada que afecta a pequeños vasos sanguíneos. Los cuatro componentes clínicos esenciales son púrpuras, dolor abdominal, artralgia y afectación renal. El caso trata de una mujer de 50 años que ingresa por dolor abdominal y hematoquecia de 72 horas de evolución, posterior a laparotomía exploratoria. Al examen físico presenta lesiones purpúricas en tronco y extremidades inferiores de 2 meses de aparición. En paraclínicos se observa hemograma con plaquetas normales, proteínas en orina 500 mg/dL, proteinuria 2,4 g/24 hs. Ante sospecha de vasculitis con plausible inclusión cutáneo-renal, se pide anticuerpos antinucleares, ANCA y se realiza biopsia cutánea evidenciándose una vasculitis neutrofílica necrotizante de pequeños vasos. En la biopsia renal se observa en inmunofluorescencia directa depósito de IgA, C3 positivo. En relación clínica de la proteinuria y compromiso cutáneo junto con la confirmación de biopsia renal se concluye en diagnóstico de púrpura de Schönlein Henoch. El interés de este caso radica en la inconsistencia de esta patología en los adultos, a pesar de que bien podría ser de una gravedad más notable dado que existe un mayor peligro de falla renal persistente.

ABSTRACT Schönlein-Henoch purpura is an immune-mediated leukocyte fragmentation vasculitis that affects small blood vessels. The four essential clinical components are purpura, abdominal pain, arthralgia, and renal involvement. This case concerns a 50-year-old woman who is admitted due to abdominal pain and hematochezia of 72 hours of evolution, after an exploratory laparotomy. On physical examination, she presents purpuric lesions on the trunk and lower extremities of 2 months of appearance. In paraclinical tests, a blood count with normal platelets, urine protein 500 mg/dL, and proteinuria 2.4 g/24 hours are observed. Suspecting vasculitis with plausible cutaneous-renal inclusion, antinuclear antibodies and ANCA are requested, and a skin biopsy is performed, showing necrotizing neutrophilic vasculitis of small vessels. In the renal biopsy, IgA deposit, C3 positive is observed in the direct immunofluorescence. In the clinical relationship of proteinuria and skin involvement together with the confirmation of renal biopsy, the diagnosis of Schönlein-Henoch purpura is concluded. The interest of this case lies in the inconsistency of this pathology in adults, despite the fact that it could be more serious given that there is a greater risk of persistent renal failure.

https://doi.org/10.18004/rvspmi/2312-3893/2022.09.02.153

Curcumin and Vinblastine Disturb Ectonucleotides Enzymes Activity and Promote ROS Production in Human Cutaneous Melanoma Cells
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Lunkes, Vinícius Leobet

; Palma, Taís Vidal

; Assmann, Charles Elias

; Mostardeiro, Vitor Bastianello

; Schetinger, Maria Rosa Chitolina

; Morsch, Vera Maria Melchiors

; Andrade, Cinthia Melazzo de

Brazilian Archives of Biology and Technology

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2022, Volume 65 elocation e22220187

Abstract: En | Text: En | PDF: En

Abstract Cancer is the leading cause of death. Melanoma skin cancer originates in melanocytes and represents 80% of the deaths associated with skin cancer. Vinblastine (VIN) is a chemotherapeutic agent used in the treatment of cancer through disrupting mitotic spindle and tumor development. Curcumin (CUR), a compound extracted from the rhizomes of the Curcuma longa plant, has beneficial effects in preventing the development and progression of cancer while modulating the immune response and oxidative stress. The expression of purinergic receptors, ecto-enzymes, and adenosine can modulate the inflammatory responses in cancer. The activity of enzymes, the markers of cell damage in oxidative stress, the generation of reactive oxygen species (ROS), and the activities of ecto-enzymes in the melanoma cell line were investigated. The human melanoma cell line was treated with curcumin (40 µM), vinblastine (VIN) (20 nM), or a combination of both for 24h. Oxidative stress enzymes and byproducts were measured and compared against the activity of ecto-enzymes. There was a marked increase in ROS production in all groups, but an increase in protein carbonylation was only detected in the VIN group. CUR had an inhibitory effect on extracellular ADP hydrolysis, as evidenced by a significant decrease in ADP substrate removal. VIN possibly increased adenosine formation, as demonstrated by an increase in ADP substrate removal. VIN (alone or in combination with CUR) reduced the activity of ADA, thus increasing the concentration of adenosine in the tumor microenvironment. CUR increased ROS generation in melanoma cells and disrupted the purinergic signaling cascade. Therefore, it may be a promising adjuvant therapy for melanoma, a cancer with a high incidence and lethality.

https://doi.org/10.1590/1678-4324-2022220187

The challenges of the pandemic and the vaccination against covid-19 in pediatric patients with kidney disease
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Soeiro, Emília Maria Dantas

; Penido, Maria Goretti Moreira Guimarães

; Palma, Lilian Monteiro Pereira

; Bresolin, Nilzete Liberato

; Lima, Eduardo Jorge da Fonseca

; Koch, Vera Hermina Kalika

; Tavares, Marcelo de Sousa

; Sylvestre, Lucimary

; Bernardes, Rejane de Paula

; Garcia, Clotilde Druck

; Andrade, Maria Cristina de

; Kaufman, Arnauld

; Chow, Charles Yea Zen

; Martins, Suelen Bianca Stopa

; Camargo, Suzana Friedlander Del Nero

Brazilian Journal of Nephrology

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/2175-8239-jbn-2022-0081en

Colonization of Panstrongylus megistus (Hemiptera:Reduvidae:Triatominae) in an urban area and its association with Didelphis marsupialis in the metropolitan region of São Paulo
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Silva, Rubens Antonio da

; Zaicaner, Raquel

; Rosa, Mariangela Palma

; Aun, Graciela Cristina Granizo

; Muniz, Júlio César

; Magalhães, Alon Carlos

; Pereira, Creusa

; Pena, Amanda Rosa

; Santos, Maysa Flexa dos

; Estevão, Vera Aparecida Oliveira

; Duarte, Agnaldo Nepomuceno

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0471-2020

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: This communication reports the colonization of Panstrongylus megistus in an urban area of the municipality of Taboão da Serra in the metropolitan region of São Paulo. METHODS: After receiving a notification from the population, entomological research comprising active search, collection, identification, and examination of triatomines was conducted. Wild animals were captured and examined. RESULTS: A colony of triatomines was found to be associated with dogs in the backyard of the property. CONCLUSIONS: The colonization of P. megistus shows the potential for their occupation of artificial ecotopes, which may pose a risk to the human population.

https://doi.org/10.1590/0037-8682-0471-2020 274 downloads

An overview of the Sixth International Conference on the Comparative Biology of Monocotyledons - Monocots VI - Natal, Brazil, 2018
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Versieux, Leonardo M.

; Calvente, Alice

; Carvalho, Fernanda Antunes

; Fonseca, Carlos Roberto

; Lichston, Juliana Espada

; Voigt, Eduardo

; Fontes, Anderson Lopes

; Roque, Alan

; Williams, Joseph Hill

; Oliveira, Reyjane Patrícia de

; Viana, Pedro Lage

; Mercier, Helenice

; Palma-Silva, Clarisse

; Wendt, Tânia

; Temponi, Lívia Godinho

; Andrade, Ivanilza Moreira de

; Oriani, Aline

; Leandro, Thales D.

; Pessoa, Edlley Max

; Martinelli, Adriana Pinheiro

; André, Thiago

; Benko-Iseppon, Ana Maria

; Berg, Cássio van den

; Luz, Cynthia Fernandes Pinto da

; Prosdocimi, Francisco

; Jardim, Jomar G.

; Alves, Marccus

; Wanderley, Maria das Graças Lapa

; Forzza, Rafaela Campostrini

; Scatena, Vera Lucia

; Clark, Lynn G.

Rodriguésia

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2021, Volume 72 elocation e00622019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Neste artigo nós apresentamos uma visão geral dos resumos, programação científica e social, viagens de campo e informações acerca do número de inscritos, países participantes, patrocínios e temas tratados durante a Sexta Conferência Internacional sobre Biologia Comparada de Monocotiledôneas, realizada em Natal, Brasil, de 7 a 12 de outubro de 2018. Alguns comentários recebidos pelos organizadores e sugestões para os organizadores do próximo Monocots, na Costa Rica, também são fornecidos. Este artigo complementa os dados publicados no livro de resumos, disponível no Repositório Digital da UFRN.

Abstract In this paper we present an overview of the abstracts, scientific and social programs, field trips, and achievements in terms of participant number, represented countries, sponsorships, and themes treated during the Sixth International Conference on the Comparative Biology of Monocotyledons that took place in Natal, Brazil, October 7th -12th 2018. Some comments received by the organizers and a few suggestions for organizers of the next meeting, in Costa Rica, are also provided. The conference’s complete abstract book was published and provide additional information.

https://doi.org/10.1590/2175-7860202172035 395 downloads

Clinical and molecular profile of a Brazilian cohort of patients with classical BCR-ABL1-negative myeloproliferative neoplasms
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Porto-Soares, Moysés Antonio

; Oliveira, Rafael Daltro de

; Cortopassi, Gabriel Macedo

; Machado-Neto, João Agostinho

; Palma, Leonardo Carvalho

; Figueiredo-Pontes, Lorena Lobo de

Hematology, Transfusion and Cell Therapy

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sep 2020, Volume 42 N. 3 Pages 238 - 244

Abstract: En | Text: En | PDF: En

ABSTRACT Background: The classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). In developing countries, there are few reports that truly reveal the clinical setting of these patients. Therefore, we aimed to characterize a single center MPN population with a special focus on the correct diagnosis based on the recent review of the WHO criteria for the diagnosis of myeloid neoplasms. Methods: This retrospective study analyzed data from medical records of patients with classical BCR-ABL1-negative MPNs diagnosed from January 1997 to October 2017 and followed at the University Hospital of Ribeirão Preto Medical School. Results: A total of 162 patients were assessed, 61 with PV, 50 with ET, and 51 with PMF. The mutational status analysis revealed that 113 (69.3%) harbored the JAK2V617F mutation, 23 (14.1%), the CALR mutation, and 12 (7.4%) had a triple-negative status. None of the patients were found to have mutations on the thrombopoietin receptor gene (MPL), including some ET and PMF patients who were not tested. Among the PV patients, 57 (93.5%) were positive for the JAK2V617F mutation, one (1.6%) presented an in-frame deletion JAK2 exon 12 mutation and one (1.6%) presented a missense JAK2 exon 9 mutation, not previously described. The overall survival was lower in the triple-negative patients with PMF, when compared to the JAK2V617F or CALR-mutated (p= 0.002). Conclusion: The frequency of somatic mutations and survival in our cohort, stratified according to the respective disease, was consistent with the literature data, despite some limitations. Further prospective epidemiological studies of MPN cohorts are encouraged in developing countries.

https://doi.org/10.1016/j.htct.2019.07.008 274 downloads

10.

Recommendations Of The Brazilian Society Of Nephrology Regarding Pediatric Patients On Renal Replacement Therapy During The Covid-19 Pandemic
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Tavares, Marcelo de Sousa

; Penido, Maria Goretti Moreira Guimarães

; Andrade, Olberes Vitor Braga de

; Koch, Vera Hermina Kalika

; Bernardes, Rejane de Paula

; Garcia, Clotilde Druck

; Moura-Neto, José A.

; Nascimento, Marcelo Mazza

; Palma, Lilian Monteiro Pereira

Brazilian Journal of Nephrology

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2020, Volume 42 N. 2 Pages 32 - 35

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução O impacto do novo coronavírus (SARS-CoV-2) e as suas manifestações clínicas (Covid-19) em todo o mundo impôs recomendações regionais específicas a populações que necessitam de cuidados especializados, como crianças e adolescentes com doenças renais, particularmente em terapias de substituição renal (TRS). Apresentamos as recomendações da Sociedade Brasileira de Nefrologia em relação ao tratamento de pacientes pediátricos com doenças renais durante a pandemia Covid-19. Método Foram avaliados e analisados os artigos e documentos sobre recomendações específicas para Covid-19 de sociedades médicas e órgãos governamentais sobre crianças em TRS, bem como aqueles focados em aspectos epidemiológicos dessa condição no Brasil. Resultados Apresentamos as recomendações sobre atendimento ambulatorial, transporte para centros de diálise, diálise peritoneal, hemodiálise e transplante renal em crianças e adolescentes durante a pandemia de Covid-19 no Brasil. Discussão Apesar das observações iniciais de taxas de mortalidade mais altas em grupos etários específicos (idosos) e com comorbidades (obesos, diabéticos e aqueles com doenças cardiovasculares), pacientes com doença renal crônica (DRC) em TRS apresentam risco significativo de evoluir com Covid-19. Medidas específicas devem ser tomadas para reduzir o risco de contrair SARS-CoV-2 e desenvolver a Covid-19, principalmente durante o transporte para instalações de diálise, bem como na chegada e no contato com outros pacientes.

ABSTRACT Introduction The impact of the new coronavirus (SARS-COV-2) and its worldwide clinical manifestations (COVID-19) imposed specific regional recommendations for populations in need of specialized care, such as children and adolescents with kidney diseases, particularly in renal replacement therapies (RRT). We present the recommendations of the Brazilian Society of Nephrology regarding the treatment of pediatric patients with kidney diseases during the COVID-19 pandemic. Methods Articles and documents from medical societies and government agencies on specific recommendations for children on RRT in relation to COVID-19 as well as those focused on epidemiological aspects of this condition in Brazil Were evaluated and analyzed. Results We present recommendations on outpatient care, transportation to dialysis centers, peritoneal dialysis, hemodialysis, and kidney transplantation in children and adolescents during the COVID-19 pandemic in Brazil. Discussion Despite initial observations of higher mortality rates in specific age groups (the elderly) and with comorbidities (obese, diabetics, and those with cardiovascular diseases), patients with chronic kidney disease (CKD) on RRT are particularly prone to develop COVID-19. Specific measures must be taken to reduce the risk of contracting SARS-CoV-2 and developing COVID-19, especially during transport to dialysis facilities, as well as on arrival and in contact with other patients.

https://doi.org/10.1590/2175-8239-jbn-2020-s108 1999 downloads

11.

Conversion of hydroxycinnamic acids into volatile phenols in a synthetic medium and in red wine by Dekkera bruxellensis
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Cabrita, Maria João

; Palma, Vera

; Patão, Raquel

; Freitas, Ana Maria Costa

Food Science and Technology

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mar 2012, Volume 32 N. 1 Pages 106 - 112

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A transformação do ácido p-cumárico, ácido ferúlico e ácido cafeico em 4-etilfenol, 4-etilguaiacol e 4-etilcatecol foi estudada na presença de Dekkera bruxelensis ISA 1791, sob condições controladas, em meio sintético e em vinho tinto. Os compostos fenólicos foram doseados por cromatografia em fase líquida (HPLC-DAD) e os fenóis voláteis foram doseados por cromatografia em fase gasosa (GC) com detector de ionização de chama (FID), recorrendo a uma metodologia que não requer prévia derivatização da amostra. A identificação dos compostos foi comprovada por espectrometria de massa (GC-MS). Os resultados demonstram que os teores em ácidos fenólicos diminuem enquanto se observa um aumento dos teores em fenóis voláteis. O ácido cafeico é dos três ácidos em estudo, o menos utilizado pela levedura, daí os teores em 4-etilcatecol serem os mais baixos observados. Esta síntese de 4-etilcatecol por Dekkeras bruxelensis em vinhos nunca tinha sido demonstrada. Os resultados obtidos contribuem, decisivamente, para um melhor conhecimento sobre a origem precisa dos fenóis voláteis nos vinhos. A acumulação destes compostos no vinho é,hoje em dia, considerada como um dos fatores-chave do controle de qualidade.

The conversion of p-coumaric acid, ferulic acid, and caffeic acid into 4-ethylphenol, 4-ethylguaiacol and 4-ethylcatechol was studied in Dekkera bruxellensis ISA 1791 under defined conditions in a synthetic medium and in a red wine. Liquid chromatography (HPLC-DAD) was used to quantify the phenolic acids, and gas chromatography (GC) coupled to a FID detector was used to quantify volatile phenols using a novel analytical methodology that does not require sample derivatization. Identification was achieved by gas chromatography-mass detection (GC-MS). The results show that phenolic acids concentration decreases while volatile phenols concentration increases. The proportion of caffeic acid taken up by Dekkera bruxellensis is lower than that for p-coumaric or ferulic acid; therefore less 4-ethylcatechol is formed. More important, 4-ethylcathecol synthesis by Dekkera bruxellensis in wine has never been demonstrated so far. These results contribute decisively to a better understanding of the origin of the volatile phenols in wines. The accumulation of these compounds in wine is nowadays regarded as one of the key factors of quality control.

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12.

Deregulated expression of A1, Bcl-2, Bcl-xL, and Mcl-1 antiapoptotic proteins and Bid, Bad, and Bax proapoptotic genes in polycythemia vera patients
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Gasparotto, Elainy Patricia Lino

; Tognon, Raquel

; Ferreira, Aline Fernanda

; Oliveira, Gislane Lelis Vilela

; Palma, Patrícia Vianna Bonini

; Zanichelli, Maria Aparecida

; Souto, Elizabeth Xisto

; Velano, Carlos Eduardo Engel

; Simões, Belinda Pinto

; Carrara, Rita de Cassia Viu

; Kashima, Simone

; Covas, Dimas Tadeu

; Castro, Fabíola Attie de

; Souza, Ana Maria de

Brazilian Journal of Pharmaceutical Sciences

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dec 2011, Volume 47 N. 4 Pages 873 - 886

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A desregulação da apoptose parece participar da fisiopatologia da policitemia vera (PV). Este estudo avaliou a expressão das moléculas da família Bcl-2 em células hematopoéticas CD34 + e leucócitos de 12 pacientes com PV. Foram realizados: a quantificação da expressão gênica por PCR em tempo real utilizando kit Sybrgreen Quantitect, avaliação da expressão de proteínas por western-blot e detecção da mutação JAK2 V617F segundo Baxter et al. (2005). Células CD34 + dos pacientes com PV apresentaram maior expressão de A1 e Mcl-1 (mediana: 22,6 e 5,2, respectivamente) em comparação com controles (0,9 e 0,5, p = 0,004 e p = 0,020) e expressão de Bcl-2 e Bcl-xL diminuída nestes pacientes (0,18 e 1,19) em relação aos controles (1,39 e 2,01, p = 0,006 e p = 0,020). Células CD34 + dos pacientes com PV mostraram expressão elevada de bid (14,4) em comparação aos controles (1,0; p = 0,002). Leucócitos dos pacientes mostraram aumento de A1 (7,41, p = 0,001) e expressão reduzida do Bax (0,19; p = 0,04) e Bad (0,2; p = 0,030). Não houve correlação entre percentagem de alelos JAK2 V617F mutados e expressão molecular. Pacientes com PV apresentaram alterações na expressão de moléculas Bcl-2 que podem interferir no controle da apoptose e contribuir para a patogênese da doença.

Apoptosis deregulation might have a role in the pathophysiology of polycythemia vera (PV). This study evaluated Bcl-2 molecule expression in CD34+ cells and leukocytes in 12 PV patients. Gene expression was investigated by real time PCR using SybrGreen Quantitect kit and protein expression was evaluated by western-blotting. JAK2 V617F mutation was detected according to Baxter et al (2005). CD34+ cells from PV patients presented higher levels of A1 and Mcl-1 expression (median: 22.6 and 5.2, respectively) in comparison with controls (0.9 and 0.5, p=0.004 and p=0.020); while Bcl-2 and Bcl-xL expression decreased in PV patients (0.18 and 1.19) compared with controls (1.39 and 2.01, p=0.006 and p=0.020). CD34+ cells in PV patients showed an elevated Bid expression (14.4) in comparison with healthy subjects (1.0; p=0.002). Patients' leukocytes showed an A1 augmentation (7.41, p=0.001) and a reduced expression of Bax (0.19; p=0.040) and Bad (0.2; p=0.030). There was no correlation between JAK2 V617F allele burden and molecular expression. PV patients showed alterations in Bcl-2 members' expression, which may interfere with control of apoptotic machinery and contribute to disease pathogenesis.

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13.

Padrões alimentares de adolescentes obesos e diferentes repercussões metabólicas
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Dishchekenian, Vera Regina Mello

; Escrivão, Maria Arlete Meil Schimith

; Palma, Domingos

; Ancona-Lopez, Fábio

; Araújo, Eutália Aparecida Candido de

; Taddei, José Augusto de Aguiar Carrazedo

Revista de Nutrição

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feb 2011, Volume 24 N. 1 Pages 17 - 29

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar a associação de padrões alimentares com alterações metabólicas em adolescentes obesos. MÉTODOS: Estudo transversal envolvendo 76 estudantes (ambos os sexos, 14-19 anos, IMC³P95 e Tanner ³4) de escolas públicas da cidade de São Paulo, Brasil. Foram coletados dados antropométricos e bioquímicos, e aplicados questionários com informações sociodemográficas e registro alimentar de 4 dias, entre 2006 e 2007. Escores fatoriais foram obtidos na análise fatorial e, após ajustes, três padrões alimentares identificados foram associados a fatores de risco biológico por regressão linear múltipla. RESULTADOS: O padrão Tradicional (arroz e massas, feijões, carnes vermelhas, embutidos, óleos e doces) foi positivamente associado com insulina, glicemia e triglicérides e negativamente associado com lipoproteína de alta densidade. O padrão Em Transição (peixe, aves, ovos, pães, manteiga, leite e derivados, hortaliças, frutas, sucos de frutas e açúcar refinado) apresentou as mesmas associações, além de associação similar com a pressão arterial diastólica. O padrão Fast Food (cafeteria, hambúrguer, maionese, bolacha, bolos e tortas, chocolate e refrigerantes) apresentou associação positiva com o colesterol, lipoproteína de baixa densidade e pressão arterial sistólica e diastólica, e associação negativa com insulina e lipoproteína de alta densidade. CONCLUSÃO: Os padrões Tradicional e Em transição apresentaram associações diferentes com o metabolismo lipídico e glicídico quando comparados com o padrão Fast Food. Os três padrões podem ser considerados obesogênicos, porém o padrão Fast Food pareceu ser o mais aterogênico e promotor de hipertensão arterial.

OBJECTIVE: This study assessed the association between dietary patterns and metabolic changes in obese adolescents. METHODS: This was a cross-sectional study of 76 students (both genders, 14-19 years old, BMI³P95 and Tanner stage ³4) enrolled in public schools from 2006 to 2007 in São Paulo city, Brazil. A sociodemographic questionnaire and 4-day food record were administered and anthropometric and biochemical data were collected. Scores for dietary patterns were assessed by factor analysis and after potential confounders were controlled, multilinear regression was used to associate the three identified patterns with biological risk factors. RESULTS: The Traditional Pattern (rice and cereals, beans, red meat, sausage, oils and sweets) was positively associated with insulin, blood glucose and triglycerides and negatively associated with high-density lipoprotein. The In-Transition pattern (fish, poultry, eggs, bread, butter, milk and dairy products, vegetables, fruits, fruit juice and white sugar), presented the same positive associations in addition to an association with diastolic blood pressure. The Fast Food pattern (high fat bakery products, hamburger, mayonnaise, cookies and crackers, chocolate and sodas) presented a positive association with cholesterol, low-density lipoprotein, systolic and diastolic blood pressure and a negative association with insulin and high-density lipoprotein. CONCLUSION: The Traditional and In-Transition patterns were differently related to glucose and lipid metabolism when compared with the fast food pattern. The three patterns could be considered obesogenic, however the Fast Food pattern seems to be the most atherogenic and promoter of hypertension.

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14.

"Standing crop" na área estuarina SW da Baía de Todos os Santos
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Peixinho, Vera Maria Carvalho

; Paredes, Jorge Falcão

; Simas, Eliana Maria Palma

Boletim do Instituto Oceanográfico

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1980, Volume 29 N. 2 Pages 283 - 289

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The present study is intended to evaluate the potential of an estuarine area surrounded by mangrove at Todos os Santos Bay (Bahia State , Brazil), for supporting aquaculture activities. From October 1977 to July 1978 samples were collected monthly on alternate tides for determination of particulate organic carbon and total proteins The following environmental parameters were also considered: salinity. temperature, pH, transparence, dissolved oxygen, silicates, ammonia, nitrites, nitrates, phosphates and precipitation. Although the area presented low ceil density and low photossinthetic activity, high values for the standing crop were found, demonstrating the importance of detritic material for the particulate organic matter.

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