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Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response.

https://doi.org/10.1016/j.abd.2023.03.002

Autoinflammatory diseases: a Latin American multicenter study according to age and sex
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Piotto, Daniela Gerent Petry

; Kozu, Katia

; Aikawa, Nádia Emi

; Carneiro, Pedro Lopes

; Katsicas, María Martha

; Oliveira, Sheila Knupp Feitosa de

; Fernandes, Taciana de Albuquerque Pedrosa

; Magalhães, Claudia Saad

; Cunha, Ana Luiza Garcia

; Bica, Blanca Elena Rios Gomes

; Rabelo Júnior, Carlos Nobre

; Battagliotti, Cristina

; Matos, Erica Naomi Naka

; Santos, Flavia Patrícia Sena Teixeira

; Sztajnbok, Flavio Roberto

; Bezrodnik, Liliana

; Bandeira, Marcia

; Rodrigues, Marta Cristine Felix

; Munittis, Pablo García

; Appenzeller, Simone

; Robazzi, Teresa Cristina Martins

; Clemente, Gleice

; Silva, Clovis Artur

; Terreri, Maria Teresa

Revista Paulista de Pediatria

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2024, Volume 42 elocation e2022184

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To evaluate autoinflammatory diseases (AID) according to age at diagnosis and sex, and response to therapy in a large population. Methods: This is a cross-sectional observational study of a Latin American registry using a designed web system for data storage, collected between 2015 and 2018. Any altered findings during follow-up were recorded. The forms were translated into Portuguese and Spanish, including demographic, clinical, laboratory, genetic and treatment characteristics. Results: We included 152 patients, 51.3% male and 75% Caucasian. The median age at disease onset was 2.1 years (0–15.6 years) and median age at diagnosis 6.9 years (0–21.9 years); 111 (73%) were children (0–9 years old), and 41 (27%) were adolescents and young adults (AYA) (10–21 years old). Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome (PFAPA) occurred in 46/152 (30%), chronic non-bacterial osteomyelitis (CNO) in 32/152 (21%), and familial Mediterranean fever (FMF) in 24/152 (15.7%). PFAPA was significantly higher in young children than in AYA (38.7% vs. 7.3%, p<0.001), while CNO were lower (13.5% vs. 41.5%, p<0.001). The frequency of females was significantly higher in CNO (28.4% vs. 14.1%, p=0.031) and lower in FMF (8.1% vs. 23.1%, p=0.011). The most used drugs were glucocorticoids, non-steroidal anti-inflammatory drugs (NSAID), and colchicine. Glucocorticoids and colchicine treatment were used in all AID with good to moderate response. However, cryopyrin-associated periodic syndromes (CAPS) seemed unresponsive to glucocorticoids. NSAIDs and methotrexate were the main medications used to treat CNO. Conclusions: Differences among AID patients were observed in the LA population regarding sex and age at disease diagnosis.

RESUMO Objetivo: Avaliar as doenças autoinflamatórias (DAI) de acordo com sexo e idade no momento do diagnóstico e a resposta terapêutica em uma grande população. Métodos: Este é um estudo observacional transversal de um registro latino-americano que usou um sistema de dados coletados entre 2015 e 2018. Quaisquer achados alterados ao longo do acompanhamento foram registrados. Os formulários foram traduzidos para os idiomas português e espanhol, incluindo características demográficas, clínicas, laboratoriais, genéticas e de tratamento. Resultados: Incluímos 152 pacientes, sendo 51,3% do sexo masculino e 75% da raça branca. A média de idade de início da doença foi de 2,1 anos (0–15,6 anos) e a média de idade de diagnóstico 6,9 anos (0–21,9 anos); 111 (73%) eram crianças (0–9 anos) e 41 (27%) adolescentes/adultos jovens (10–21 anos). A síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA) ocorreu em 46/152 (30%), osteomielite não bacteriana crônica (CNO) em 32/152 (21%) e febre familiar do Mediterrâneo (FMF) em 24/152 (15,7%). A PFAPA foi significativamente maior em crianças pequenas (38,7 vs. 7,3%, p<0,001), e a CNO, em adolescentes/adultos jovens (13,5 vs. 41,5%, p<0,001). A frequência do sexo feminino foi significativamente maior na CNO (28,4 vs. 14,1%, p=0,031) e menor na FMF (8,1 vs. 23,1%, p=0,011). Os medicamentos mais utilizados foram glicocorticoides, anti-inflamatórios não esteroidais (AINE) e colchicina. O tratamento com glicocorticoides e colchicina foi usado em todas as DAI com resposta boa a moderada. No entanto, as síndromes periódicas associadas à criopirina (CAPS) pareciam não responder aos glicocorticoides. AINE e metotrexato foram os principais medicamentos utilizados no tratamento da CNO. Conclusões: Diferenças de pacientes com DAI foram observadas na população latino-americana em pacientes agrupados por sexo e idade ao diagnóstico da doença.

https://doi.org/10.1590/1984-0462/2024/42/2022184

Quasi-iatrogenia vascular - dois relatos de caso
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Pires, Patrícia

; Sousa, Gonçalo

; Afonso, Ana

; Vieira, João

; Marques, Gil

; Gonçalves, Ana

; Barroso, Pedro

; Gonzalez, Antonio

; Ferreira, Maria José

Angiologia e Cirurgia Vascular

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dec 2023, Volume 19 N. 4 Pages 231 - 234

Abstract: Pt | Text: Pt | PDF: Pt

Resumo Introdução: As lesões vasculares iatrogénicas são uma causa importante de morbilidade e mortalidade após intervenções cirúrgicas ortopédicas ou neurocirúrgicas. Neste artigo, os autores apresentam dois casos clinicos de quasi-iatrogenia vascular. Casos clínicos: Dois casos, um procedimento ortopédico e um procedimento neurocirúrgico, são apresentados. O primeiro caso refere-se a uma mulher de 80 anos com migração do componente acetabular de uma prótese da anca, associado a trombose da veia ilíaca externa. O segundo caso reporta um homem de 27 anos com compressão medular ao nível de D6 por motivo de um hemangioma ósseo. Após a operação, verificou-se a presença de material de fixação (parafuso) fazendo protusão para o lúmen da aorta torácica. Este foi removido num segundo momento. Ambas as operações decorreram sem complicações. Conclusão: Os autores consideram que uma abordagem multidisciplinar contribuiu significativamente para o sucesso dos casos apresentados.

https://doi.org/10.48750/acv.540

Fertilidad edáfica y nutrición en el cultivo de cacao (Theobroma cacao L.) en tres suelos de Tabasco, México
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Francisco-Santiago, Sandra Patricia

; Palma-López, David Jesús

; Sánchez-Hernández, Rufo

; Obrador-Olán, José Jesús

; García-Alamilla, Pedro

Terra Latinoamericana

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dec 2023, Volume 41 elocation e1116

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Summary: Cocoa is a traditional crop in southern Mexico, although its productivity is low due to edaphic and nutritional limitations. Hence, the aim of our research was to diagnose edaphic fertility and the nutritional content of cacao plantations in the main groups of cultivated soils in La Chontalpa, the main cocoa production area of Tabasco state, to identify the edaphic and nutritional variables that restrict crop productivity. Through the analysis of satellite images, sampling sites were selected in representative soils of the study area and the coordinates were geopositioned to locate them. Soil profiles were described to classify the soils of the sampling sites. Soil samples were collected at depths of 0-10, 10-30 and 30-50 cm, to determine variables of soil fertility. In producer trees, foliar samples were collected to determine the concentrations of macronutrients. The results indicate that the plantations are cultivated on Vertisols, Cambisols and Fluvisols, which do not show restrictions in most of the edaphic properties. However, due to the low C/N ratio (< 12) of the soils, there is a decrease in the OM and N contents, which are added to a K deficit, causing low concentrations of both macronutrients in the foliage of the plants. In conclusion, the main edaphic restrictions that can affect cocoa cultivation in La Chontalpa are the rapid loss of OM and a deficit of N and K in the soil, which cause low concentrations of both nutrients in the foliage of the trees.

Resumen: El cacao es un cultivo tradicional en el sur de México, que exhibe baja productividad debido a limitantes edáficas y de nutrición, por lo que el objetivo de la investigación fue diagnosticar la fertilidad edáfica y contenido nutrimental de las plantaciones de cacao, en los principales grupos de suelos cultivados en la Chontalpa, principal zona productora de Tabasco, para identificar las variables del suelo y nutrimentales que restringen la productividad del cultivo. Mediante análisis de imágenes satelitales, se seleccionaron sitios de muestreos en suelos representativos del área de estudio y se geoposicionaron las coordenadas para ubicarlos. Se describieron perfiles de suelos para clasificar los suelos de los sitios de estudio, y se colectaron muestras de suelos a las profundidades de 0-10, 10-30 y 30-50 cm, para determinar variables indicadoras de la fertilidad del suelo. En árboles productores se colectaron muestras foliares para determinar las concentraciones de macronutrientes. Los resultados indican que las plantaciones se cultivan sobre Vertisols, Cambisols y Fluvisols, que no presentan restricciones en la mayoría de las propiedades edáficas. Sin embargo, debido a la baja relación C/N (< 12) de los suelos, hay una disminución en los contenidos de MO y N, que se suman a un déficit de K, que provocan bajas concentraciones de ambos macronutrientes en el follaje de las plantas. Se concluye que las principales restricciones edáficas que pueden afectar al cultivo del cacao en la Chontalpa son la rápida pérdida de MO y déficit de N y K en el suelo, que provocan bajas concentraciones de ambos nutrientes en el follaje de los árboles.

https://doi.org/10.28940/terra.v41i0.1116

Third National Registry of Cardiac Rehabilitation Programs in Mexico (RENAPREC III-2022)
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Lara-Vargas, Jorge A.

; Ilarraza-Lomelí, Hermes

; García-Saldivia, Marianna

; Pineda-García, Alfredo D.

; Leyva-Valadez, Eduardo A.

; Justiniano-Cordero, Samuel

; Sahagún-Olmos, Roberto

; Zavala-Ramírez, Juana

; Cassaigne-Guasco, María E.

; Sánchez-Limón, Edgar-F

; Castañeda-López, Javier

; Cerón-Enríquez, Norma

; Ku-González, Andrés

; Arteaga-Martínez, Rodolfo

; Hinojosa-López, Tania

; Vergara-Guzmán, Jéssica

; Pérez-Vázquez, Daniel I.

; Gasca-Zamudio, Pedro D.

; Aranda-Ayala, Zulema L.

; Vacío-Reyes, Martha E.

; Reza-Orozco, Marco

; Alcocer-Gamboa, Miguel A.

; Hernández-González, Pedro A.

; Pérez-Reyes, Angélica A.

; Núñez-Urquiza, Juan P.

; Alonso-Sánchez, Jesús

; Franco-Valles, Sarahí

; Romo-Escamilla, Ricardo E.

; Nuriulú-Escobar, Patricia

; Serna-Santamaría, Iván

; Avilés-González, Jorge

; Salgado-Solorio, María C.

; Muñoz-Gutiérrez, Luz M.

; Mendoza-Díaz, Pedro M.

; Ávila-Estrada, Ángel

; Morales-Medina, Carlos

; Lara-Vázquez, Eduardo

; Rodríguez-Herrera, Paulina

; Galván-López, María

; Segoviano-Mendoza, Georgina

; De-la-Torre-Cruz, Fabiola

; Jiménez-Campos, Cecilia

; Ramírez-Meléndez, Alejandra

; Almaraz-Ríos, Alejandro

; González-Bonilla, Mezthly

; Rojano-Castillo, Jessica

; Rius-Suarez, María D.

Archivos de cardiología de México

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dec 2023, Volume 93 N. 4 Pages 405 - 416

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: In Mexico, cardiac rehabilitation (CR) as an interdisciplinary intervention with therapeutic impact in patients with heart disease is growing. There is the need to know actual conditions of CR in our country. Objectives: The objective of this National Registry is to follow-up those existing and new CR units in Mexico through the comparison between the two previous registries, RENAPREC-2009 and RENAPREC II-2015 studies. This is a descriptive study focused on diverse CR activities such as assistance training, and certification of health professionals, barriers, reference, population attended, interdisciplinarity, permanence over time, growth prospects, regulations, post-pandemic condition, integrative characteristics, and scientific research. Results: Data were collected from 45 CR centers in the 32 states, 75.5% are private practice units, 67% are new, 33% were part of RENAPREC II-2015, and 17 have continued since 2009. With a better distribution of CR units along the territory, the median reference of candidates for CR programs is 9% with a significant reduction into tiempo of enrollment to Phase II admission (19 ± 11 days). Regarding to previous registries, the coverance of Phases I, II, and III is 71%, 100%, and 93%, respectively; and a coverance increases in evaluation, risk stratification, and prescription, more comprehensive attendance and prevention strategies. Conclusions: CR in Mexico has grown in the past 7 years. Even there is still low reference and heterogeneity in specific processes, there are strengths such as interdisciplinarity, scientific professionalization of specialists, national diversification, and an official society that are consolidated over time.

https://doi.org/10.24875/acm.22000235

Organic and mineral fertilization determining the agronomic performance of sunflower cultivars and soil chemical attributes
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Silva, Weslian V. da

; Taveira, José H. da S.

; Fernandes, Patrick B.

; Silva, Patrícia C.

; Costa, Ana B. G. da

; Costa, Carolina M.

; Giongo, Pedro R.

; Corioletti, Níbia S. D.

; Gurgel, Antonio L. C.

Revista Brasileira de Engenharia Agrícola e Ambiental

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dec 2023, Volume 27 N. 12 Pages 927 - 933

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT This study aimed to verify the effect of the application of filter cake, via soil and in association with mineral fertilization, on sunflower cultivars (Helianthus annuus L.) and the chemical properties of the soil. The experimental design used was randomized blocks in a 3 × 2 factorial scheme with six replicates, totaling 36 experimental units. Three sunflower cultivars (Sany 66, Nusol 4140, and Nusol 4170) and two fertilization strategies (mineral fertilization with and without filter cake) were used. Resorting to the filter cake increased the oil concentration in Sany 66. Mineral fertilization did not significantly affect achene production, with mean values being 2561.58 kg ha-1. However, including filter cake resulted in a 21% increase in phosphorus (P) content in the 0-0.20 m soil layer in sunflower crops of the Nusol 4140 variety. Therefore, fertilization with filter cake, in combination with chemical fertilizers or alone, can be an effective strategy to increase soil P content and oil concentration in sunflower cultivation.

RESUMO Este estudo teve como objetivo verificar o efeito da aplicação de torta de filtro, via solo e em associação com a fertilização mineral, em cultivares de girassol (Helianthus annuus L.) e nas propriedades químicas do solo. O delineamento experimental utilizado foi em blocos casualizados, em esquema fatorial 3 × 2, com seis repetições, totalizando 36 unidades experimentais. Foram utilizadas três cultivares de girassol (Sany 66, Nusol 4140 e Nusol 4170) e duas estratégias de fertilização (fertilização mineral com e sem torta de filtro). O uso da torta de filtro aumentou a concentração de óleo na cultivar Sany 66. A fertilização mineral não afetou a produção de aquênios, sendo obtido valores médios de 2561,58 kg ha-1. No entanto, a inclusão da torta de filtro resultou em um aumento de 21% no teor de fósforo (P) na camada de solo de 0-0,20 m em cultivos de girassol da variedade Nusol 4140. Portanto, a fertilização com torta de filtro, em combinação com fertilizantes químicos ou isoladamente, pode ser uma estratégia eficaz para aumentar o teor de P no solo e a concentração de óleo no cultivo de girassol.

https://doi.org/10.1590/1807-1929/agriambi.v27n12p927-933

Unraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosa
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Barros, Elcio Daniel S.

; Monção Filho, Evaldo S.

; Fonseca, Mariluce G.

; Alves, Patrícia S.

; Santos, Antônia Laíres S.

; Feitosa, Chistiane M.

; Silva, Dulce Helena S.

; Costa, Pedro Mikael S.

; Pessoa, Cláudia

; Campos, Carmem D. L.

; Monteiro, Cristina A.

; Chaves, Mariana Helena

; Vieira Júnior, Gerardo M.

Journal of the Brazilian Chemical Society

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oct 2023, Volume 34 N. 10 Pages 1398 - 1409

Abstract: En | Text: En | PDF: En

Toads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piauí state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 µg mL-1) and prostate (IC50 = 1.6 µg mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 µg mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.

https://doi.org/10.21577/0103-5053.20230052

Selectivity of post-emergence herbicides in soybean and their efficacy on the control of Conyza spp.
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Silva, Paulo V. da

; Medeiros, Elias S. de

; Schedenffeldt, Bruna

; Vendruscolo, Marlon A.

; Zamignam, Daniel

; Salmazo, Pedro A. V.

; Dias, Roque de C.

; Mauad, Munir

; Bicalho, Carolina C.

; Monquero, Patricia A.

Revista Brasileira de Engenharia Agrícola e Ambiental

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aug 2023, Volume 27 N. 8 Pages 600 - 609

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT The management of Conyza spp. is becoming increasingly challenging in soybean, especially post-emergence; therefore, it must be linked to the effectiveness of control with selectivity. This study aimed to evaluate the phytotoxic effects on soybean and the control of Conyza spp. at an advanced phenological stage through different post-emergence herbicides registered for soybean. The experimental design was randomized blocks with plots divided in time with 4 replications, consisting of 14 treatments: cloransulam at three different doses (30, 35, and 40 g a.i. ha-1); fomesafen (250 g a.i. ha-1); imazethapyr (100 g a.i. ha-1); chlorimuron in three different doses (15, 18, and 20 g a.i. ha-1); flumetsulam (108 g a.i. ha-1); lactofen (180 g a.i. ha-1); bentazon (720 g a.i. ha-1); and flumiclorac (60 g a.i. ha-1). All were associated with glyphosate (1080 g a.i. ha-1), in addition to two controls, one weeded and the other without. Visual assessments of phytotoxicity in the soybean crop and weed control were performed at 7, 14, 21, 28, and 35 days after treatment (DAT). Bentazon stood out among all treatments, showing adequate selectivity in soybean, in addition to effective weed control at 14 DAT. No dose of cloransulam or chlorimuron herbicide was effective in controlling Conyza spp. The phenological stage of Conyza spp. and water availability impacted weed control of post-emergence herbicides and selectivity in soybean.

RESUMO O manejo de Conyza spp., se torna cada vez mais desafiador em soja, principalmente na pós-emergência, logo, deve-se atrelar eficácia de controle com seletividade. Este trabalho teve como objetivo avaliar os efeitos fitotóxicos na cultura da soja e o controle de Conyza spp. em estágio fenológico avançado, através de diferentes herbicidas registrados em pós-emergência para a cultura da soja. O delineamento experimental foi o de blocos ao acaso com parcelas subdividadas no tempo com 4 repetições, sendo composto por 14 tratamentos: cloransulam em três diferentes doses (30, 35 e 40 g.i.a.ha-1); fomesafen (250 g i.a. ha-1); imazethapyr (100 g i.a. ha-1); chlorimuron em três diferentes doses (15,18 e 20 g i.a. ha-1);flumetsulam (108 g i.a. ha-1); lactofen (180 g i.a. ha-1); bentazon (720 g i.a. ha-1) e flumiclorac (60 i.a. ha-1). Todos foram associados com o glifosato (1080 g i.a. ha-1), além de duas testemunhas,uma capinada e outra sem. Foram realizadas avaliações visuais de fitotoxicidade na cultura da soja e de controle na planta daninha nos 7, 14, 21, 28 e 35 dias após tratamento (DAT). O bentazon se destacou entre todos os tratamentos, apresentando adequada seletividade na soja, além de efetivo controle de plantas daninhas aos 14 DAT. Nenhuma dose dos herbicidas cloransulam e chlorimuron foram eficazes no controle de Conyza spp. O estádio fenológico de Conyza spp. e a disponibilidade hídrica impacta o controle de plantas daninhas em herbicidas de pós-emergência e seletividade em soja.

https://doi.org/10.1590/1807-1929/agriambi.v27n8p600-609

Management strategies for Anredera cordifolia in coffee culture
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Silva, Paulo V. da

; Coeti, João P. Z.

; Ferrari, Andrea

; Melo, Karolainy T. da S.

; Dias, Roque de C.

; Schedenffeldt, Bruna F.

; Monquero, Patricia A.

; Salmazo, Pedro A. V.

; Medeiros, Elias S. de

; Bicalho, Carolina C.

; Mauad, Munir

Revista Brasileira de Engenharia Agrícola e Ambiental

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aug 2023, Volume 27 N. 8 Pages 585 - 592

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Coffee plantations installed at high altitudes and near forested areas have been highly infested with Anredera cordifolia. The objective of this work was to evaluate the effectiveness of different pre- and post-emergence herbicide treatments on A. cordifolia after mechanical mowing. A field experiment was carried out in a coffee plantation with natural infestation of A. cordifolia in a completely randomized design with a split-plot scheme and four replicates, in which the main plot an herbicides application and the subplot was the days after the initial application (DAI). The treatments were as follows: saflufenacil + glyphosate (70 + 960 g a.i. ha-1); chlorimuron + glyphosate (80 + 960 g a.i. ha-1); metsulfuron + glyphosate (6 + 960 g a.i. ha-1); flumioxazin + glyphosate (25 + 960 g a.i. ha-1), and glyphosate (960 g a.i. ha-1); with sequential application of glyphosate (960 g a.i. ha-1); glyphosate + indaziflam (960 + 75 g a.i. ha-1); indaziflam (75 g a.i. ha-1); and a control without herbicide application. Mechanical control, followed by the application of the treatments flumioxazin + glyphosate and metsulfuron + glyphosate in the first application and sequential application of indaziflam, proved to be effective. Control of this weed should be based on the removal of its plant residues from the field to reduce the regrowth and germination of aerial tubers.

RESUMO Plantações de café instaladas em altitudes elevadas e próximas a áreas florestais têm sido altamente infestadas por Anredera cordifolia. O objetivo deste estudo foi avaliar a eficácia de diferentes tratamentos herbicidas pré e pós-emergência sobre A. cordifolia após roçada mecânica. Para tanto, foi conduzido um experimento de campo em uma lavoura de café com infestação natural de A. cordifolia em um delineamento inteiramente casualizado com esquema de parcelas subdivididas com quatro repetições, sendo a parcela principal os tratamentos com aplicação de herbicida e a subparcela os dias após a aplicação inicial (DAI). Os tratamentos foram compostos por: saflufenacil + glifosato (70 + 960 g i. a. ha-1); clorimuron + glifosato (80 + 960 g i. a. ha-1); metsulfuron + glifosato (6 + 960 g i. a. ha-1); flumioxazin + glyphosate (25 + 960 g i. a. ha-1) e glifosato (960 g i. a. ha-1); com uma aplicação sequencial de: glifosato (960 g i. a. ha-1); (6) glifosato + indaziflam (960 g i. a. ha-1); e indaziflam (75 g i. a. ha-1), além de uma testemunha sem aplicação de herbicida. O manejo integrado é fundamental para o controle adequado de A. cordifolia, devido ao seu desenvolvimento vegetativo agressivo. O controle mecânico, seguido da aplicação dos tratamentos flumioxazin + glyphosate e metsulfuron + glyphosate na primeira aplicação e indaziflam sequencial mostrou-se eficaz. O controle dessa planta daninha deve ser baseado na remoção de seus resíduos vegetais do campo para reduzir a rebrota e a germinação de tubérculos aéreos.

https://doi.org/10.1590/1807-1929/agriambi.v27n8p585-592

10.

Evaluation of Reinforcement Corrosion in Cementitious Composites Modified with Water Treatment Sludge
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Rezende, Mariana A. M.

; Gromboni, Pedro P.

; Corradini, Patricia G.

; Sales, Almir

; Mascaro, Lucia H.

Journal of the Brazilian Chemical Society

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aug 2023, Volume 34 N. 8 Pages 1100 - 1108

Abstract: En | Text: En | PDF: En

The water treatment sludge (WTS) is a residue composed of organic and inorganic matter in a solid, liquid, and gaseous state that has a variable composition concerning its physical, chemical, and biological characteristics. The irregular disposal of WTS can promote harmful changes to the environment, such as reduction of dissolved oxygen and increase in the concentration of aluminum and other metals in the receiving watercourses. To propose a suitable purpose for this residue, this work evaluated the physical and mechanical properties of the concrete and corrosion resistance of the reinforcement in a cementitious composite using WTS in replacement to the natural sand. A conventional concrete and a conventional mortar were used as a reference and a 3% WTS-content concrete, and a 3% WTS-content mortar were prepared to evaluate the WTS influence in mechanical properties and corrosion resistance. By electrochemical measurements, it was observed that the resistance of the cementitious matrix was not altered by WTS addition. Regarding steel resistance, the WTS may promote a higher susceptibility to frame corrosion, which can be correlated to the lower pH than reference medium (REF). The concrete reinforcement characterization indicates that concretes with WTS can be used as reinforced concrete structure in urban areas.

https://doi.org/10.21577/0103-5053.20230023

11.

Deep Vein Thrombosis after a Supracondylar Fracture of the Humerus in a Child – A Rare Complication
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Ferrão, Ana Moreira

; Fernandes, Pedro

; Wircker, Patrícia

; Catarino, Joana

; Arcângelo, Joana

; Ovídio, Joana

Revista Brasileira de Ortopedia

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aug 2023, Volume 58 N. 4 Pages 672 - 675

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Deep vein thrombosis in the upper extremities is uncommon, especially in the pediatric population and in the trauma setting. The diagnosis is challenging, due to its rarity, requiring a high degree of suspicion. We describe a rare case of humeral vein thrombosis after a displaced supracondylar fracture of the humerus in a 7-year-old girl. The risk factors for thromboembolism and sequelae are also discussed. The early detection and treatment are mandatory to prevent poor outcomes, such as fatal thromboembolism.

Resumo Trombose venosa profunda nas extremidades superiores é incomum, especialmente na população pediátrica e no ambiente do trauma. O diagnóstico é desafiador, devido a sua raridade, exigindo alto grau de suspeita. Descrevemos um caso raro de trombose venosa úmera após uma fratura supracondilar deslocada do úmero em uma menina de 7 anos. Os fatores de risco para tromboembolismo e sequelas também são discutidos. A detecção e o tratamento precoces são obrigatórios para evitar desfechos ruins, como tromboembolismo fatal.

https://doi.org/10.1055/s-0040-1722580

12.

Fitting Structure-Data Files (.SDF) Libraries to Progenesis QI Identification Searches
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Sanches, Pedro H. G.

; Oliveira, Danilo C. de

; Reis, Ivan G. M. dos

; Fernandes, Anna M. A. P.

; Silva, Alex A. R.

; Eberlin, Marcos N.

; Carvalho, Patrícia O.

; Duarte, Gustavo H. B.

; Porcari, Andreia M.

Journal of the Brazilian Chemical Society

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jul 2023, Volume 34 N. 7 Pages 1013 - 1019

Abstract: En | Text: En | PDF: En

Progenesis QI (PQI) is a multiplatform bioinformatics tool that facilitates the identification workflow for metabolomics experiments. PQI uses fragmentation data provided by MassBank of North America (MoNA) libraries, among others, for metabolite annotation. However, PQI does not officially support MoNA libraries and other libraries based on structure-data files (.sdf). This paper describes the development and application of a software named MoNA to Progenesis QI Library Converter, allowing PQI and MoNA by correcting the fragmentation data of the library for Progenesis readability. We evaluated several public experimental datasets, including human plasma, plant extracts, cultured cells, bacteria, rat serum, and rat hippocampus. The results showed that it is mandatory to proceed with file conversion of each library to allow PQI to access fragmentation information from .msp (main spectra profile) files. This step is highly recommended to improve the identification level of the metabolites.

https://doi.org/10.21577/0103-5053.20230016

13.

Depression, suicide ideation, and irrational beliefs: Explanatory models in psychology students
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Rosas-Fuentes, Pedro David

; Valdés-García, Karla Patricia

; Monroy-Velasco, Iris Rubí

; Pérez-Pedraza, Bárbara de los Ángeles

; Sánchez-Loyo, Luis Miguel

Salud mental

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apr 2023, Volume 46 N. 2 Pages 61 - 67

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción Para la terapia racional emotiva conductual las creencias irracionales tienen un gran peso en la salud mental, ya que la presencia de estas genera padecimientos como depresión e ideación suicida. Se sabe que en el mundo estos padecimientos han ido en aumento, por ello, es importante explorar factores que faciliten su explicación. Objetivo Generar modelos explicativos para la depresión y la ideación suicida desde las creencias irracionales en estudiantes de psicología. Método Estudio cuantitativo, no experimental, transversal con análisis multivariado. Resultados Se realizaron modelos explicativos; uno para la depresión y otro para ideación suicida. La sintomatología depresiva se explica en 39% con la presencia de creencias irracionales de perfeccionismo, evitación de responsabilidades, preocupación por el futuro y determinismo del pasado. Por otro lado, la ideación suicida se explica en 54% con la presencia de las creencias de perfeccionismo, evitación de responsabilidades, locus de control externo y determinismo del pasado. Discusión y conclusión La depresión e ideación suicida en estudiantes de psicología se puede explicar en parte por creencias irracionales de perfeccionismo, locus de control externo, preocupación por el futuro, evitación de responsabilidades y determinismo del pasado. A través de enfoques de atención clínica es factible modificar dichas creencias con el objetivo de disminuir sintomatología y promover la salud mental.

Abstract Introduction In rational emotive behavioral therapy, irrational beliefs are significant in mental health since their presence leads to conditions such as depression and suicidal ideation. Since these conditions have been increasing worldwide, it is essential to explore the factors that contribute to their understanding. Objective To design explanatory models for depression and suicidal ideation based on irrational beliefs in psychology students. Method Quantitative, non-experimental, cross-sectional study with multivariate analysis. Results Two explanatory models were designed: one for depression and the other for suicidal ideation. Thirty-nine per cent of depressive symptomatology can be explained by the presence of irrational beliefs concerning perfectionism, avoidance of responsibilities, concern over the future, and the determinism of the past. At the same time, 54% of suicidal ideation can be explained by the presence of beliefs centering on perfectionism, avoidance of responsibilities, external locus of control, and the determinism of the past. Discussion and conclusion Depression and suicidal ideation in psychology students can partly be explained by irrational beliefs concerning perfectionism, external locus of control, concern over the future, avoidance of responsibilities, and the determinism of the past. Clinical care approaches can modify these beliefs to reduce symptoms and promote mental health.

https://doi.org/10.17711/sm.0185-3325.2023.009

14.

Cirugía ortognática y rehabilitación implantosoportada simultáneas mediante implantes subperiósticos o supraóseos personalizados
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Villarreal-Renedo, Pedro

; Gancedo-Pérez, Beatriz

; Villarreal-González, Adrián

; Roldán-Otero, Patricia

; Fernández-González, Verónica

; Requena-Pérez, María Victoria

Revista Española de Cirugía Oral y Maxilofacial

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mar 2023, Volume 45 N. 1 Pages 26 - 30

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT We present a clinical case in which, using subperiosteal or supraosseous implants, that is to say, three-dimensional personalized metallic titanium structures manufactured digitally, we have managed to achieve two objectives at the same time: 1) correction of a severe facial deformity, and 2) furnish the patient with fixations or implants for the implant-supported rehabilitation of her complete maxillary edentulism. We are not aware of any similar case published in the literature to date. We believe that this new, relatively simple technique can be an alternative to complex surgeries that involve the use of complicated bone grafts, with the consequent savings in time and morbidity for patients who associate maxillary hypoplasia and edentulism with severe bone atrophy.

RESUMEN Presentamos un caso clínico donde, utilizando implantes subperiósticos o supraóseos, es decir, estructuras metálicas tridimensionales personalizadas de titanio fabricadas de forma digital, hemos conseguido realizar dos objetivos a la vez: 1) la corrección de una severa deformidad facial, y 2) dotar a la paciente de fijaciones o implantes para la rehabilitación implantosoportada de su edentulismo maxilar completo. No tenemos constancia de ningún caso similar publicado en la literatura a día de hoy. Creemos que esta nueva técnica, relativamente sencilla, puede ser una alternativa a las cirugías complejas que involucran el empleo de complicados injertos óseos, con el consiguiente ahorro en tiempo y morbilidad para los pacientes que asocian hipoplasia maxilar y edentulismo con grave atrofia ósea.

https://doi.org/10.20986/recom.2023.1407/2022

15.

Synthesis and Evaluation of Antibacterial Activity of 1,2,3-Triazole and Ether Derivatives of Paeonol
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Figueroa, Laura Patricia R.

; Santos, Nayara A. dos

; Santiago, Pedro Henrique O.

; Romão, Wanderson

; Lacerda Junior, Valdemar

; Ellena, Javier

; Micheletti, Ana Camila

; Borges, Warley S.

Journal of the Brazilian Chemical Society

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jan 2023, Volume 34 N. 1 Pages 25 - 35

Abstract: En | Text: En | PDF: En

Multi-drug-resistant bacteria (MDR) are the cause of different infections and diseases that have affected humanity for a long time, and have been an emerging global health problem that has led to increased morbidity and mortality. The growing emergence of MDR bacteria has underlined the need for development and discovery of new antibacterial compounds. In this context, a series of new paeonol 1,2,3-triazole and ether derivatives were synthesized using copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and nucleophilic substitution. Paeonol has been a natural product widely studied due to its many biological activities, as well as its derivatives. Three ether derivatives (two unpublished) and ten triazole derivatives (six unpublished) of paeonol were obtained, which were determined by nuclear magnetic resonance (NMR), Fourier transform infrared spectrometry (FTIR), Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and six of them by X-rays, which is the first study of this type presented for these compounds. All the synthesized compounds were evaluated as antibacterial agents against Staphylococcus aureus and Escherichia coli, obtaining a minimum inhibitory concentration (MIC) above 100 µg mL-1. The results showed that CuAAC and nucleophilic substitution were very useful to obtain new paeonol triazole and ether derivatives and the products were obtained in yields from 21.3 to 98.5%. The advantages of these reactions (high yield in most compounds, reaction time, low impurities) show that using the method to produce new derivatives is advisable thus assisting in the discovery of new potential bioactive compounds.

https://doi.org/10.21577/0103-5053.20220085

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