ABSTRACT The global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose.

ABSTRACT Aim To prepare a consensus document of the cariology contents and competences included in the curriculum for the dentistry degree at Argentine dental faculties/schools Materials and Method Planning the process in stages: Stage 1- Diagnosis of the situation (Google Form) and invitation to participate extended to the 20 academic units (AU) that offer dentistry degrees. Stage 2- Assessment process of Content (C) and Competences (I) agreements in the five domains: D1 Basic Sciences, D2 Risk and diagnosis of dental caries, D3 Decision-making for non-invasive treatments, D4 Decision-making for invasive treatment, and D5 Evidence-based cariology at community level. Stage 3- Consensus. Stages 2 and 3 were held in Workshop format in virtual mode (W) Results Stage 1- Of the total 20 Google forms sent to the AU, 13 responses were received: 7 from National Universities and 6 from Private Universities. All participants agreed to be part of the consensus. Stage 2- W: 20 representatives from 10 AU participated. It began with a contextualizing conference, after which the representatives were divided into 5 groups to assess the agreements of each D. Stage 3- The Cariology Curriculum document was organized into 5 Domains, and 23 C and 31 I of clinical application were defined for teaching cariology. The contents and competences for each domain were agreed upon. The final document was sent to all W participants for their approval and dissemination in each AU involved Conclusion Cariology contents were defined for dentistry students at Universities in the Argentine Republic.

RESUMEN Objetivo Elaborar un documento de consenso de los contenidos y competencias de cariología en el currículo para las facultades/escuelas de odontología argentinas, a nivel del grado Materiales y Método El proceso de creación se efectuó en etapas: 1- Diagnóstico de situación (Formulario electrónico) e invitación a participar a las 20 unidades académicas (UA) donde se imparte la carrera de odontología. 2- Proceso de valoración de acuerdos de Contenidos (C) y Competencias (I) en los cinco dominios (D): D1: Ciencias Básicas; D2: Riesgo y diagnóstico de caries dental; D3: Toma de decisiones tratamientos no invasivos; D4: Toma de decisiones para el tratamiento invasivo y D5: Cariología basada en la evidencia a nivel comunitario. 3- Etapa de consenso. Las etapas 2 y 3 se efectuaron en formato de Workshop en modalidad virtual (W) Resultados Etapa 1: Del total de 20 formularios enviados a las UA se recibieron 13 respuestas (65%), 7 (53,8%) de Universidades Nacionales y 6 (46,1%) de gestión Privada. El 100% de los participantes estuvieron de acuerdo en formar parte del consenso. Etapa 2: W: Participaron 20 representantes de 10 UA. El proceso se inició con una conferencia contextualizadora, posteriormente los representantes fueron divididos en 5 grupos para la valoración de acuerdos de cada D. Etapa 3: El documento de658. 658.l Currículo en Cariología se organizó en 5 Dominios. Se definieron 23 C y 31 I de aplicación clínica para la enseñanza de la Cariología. Se consensuaron los contenidos y las competencias para cada uno de los dominios. El documento final fue enviado a todos los participantes del W para su aprobación y difusión en cada una de las UA involucradas Conclusión En base al trabajo realizado se determinó un consenso de competencias y contenidos en cariología para estudiantes de grado de Odontología, de las Universidades de la República Argentina.

Abstract Objective: to evaluate clinical, metabolic and body characteristics related to the metabolically unhealthy phenotype (MUH) in menopausal women who practice resistance training (RT). Methods: cross-sectional study with a sample of 31 women. Clinical and metabolic variables were measured. Body adiposity was assessed by body mass index, waist circumference, visceral adiposity index (VAI) and lipid accumulation product (LAP). Body composition analysis was performed by DEXA. Results: the prevalence of the MH phenotype was 74.2 %. Metabolically healthy (MH) women were younger, had more years of RT practice, higher HDL-c levels and lower VAI and android/gynoid ratio (A/G) than the MUH women. Women with inadequacy of HDL-c, TG, A/G and VAI had 12.50 (95 % CI: 3.30-47.23), 4.83 (95 % CI: 2.37-9.85), 5.20 (95 % CI: 1.90-14.16) and 3.12 (95 % CI: 1.07-9.04) times greater prevalence of the MUH phenotype, respectively, than those with adequacy of these parameters. Binary logistic regression analysis demonstrated that age is a predictor of the MUH phenotype (OR = 1.254; 95 % CI: 1.00-1.56) and this variable showed correlation with TG, VAI and A/G. There was no association between thyrotropin and MUH phenotype in the present sample. Conclusion: age and visceral adiposity are predictors for the MUH phenotype in RT practitioners in menopause, which may initially be characterized by alterations in serum lipid profile.

Resumen Objetivo: evaluar las características clínicas, metabólicas y corporales relacionadas con el fenotipo metabólicamente no saludable (MNS) en mujeres menopáusicas que practican entrenamiento de resistencia (ER). Métodos: estudio transversal con 31 mujeres. Se midieron variables clínicas y metabólicas. La adiposidad corporal se evaluó mediante el índice de masa corporal, la circunferencia de la cintura, el índice de adiposidad visceral (IAV) y el producto de acumulación de lípidos (PAL). El análisis de composición corporal fue realizado por DEXA. Resultados: la prevalencia del fenotipo metabólicamente saludable (MS) fue del 74,2 %. Las mujeres metabólicamente saludables (MS) eran más jóvenes, tenían más años de práctica de ER, niveles más altos de HDL-c y menor IAV y relación androide/ginoide (A/G) que las mujeres MNS. Hubo asociación del fenotipo MNS con los niveles de HDL-c y A/G. Las mujeres con insuficiencia de HDL-c, TG, A/G y IAV tuvieron 12,50 (IC 95 %: 3,30-47,23), 4,83 (IC 95 %: 2,37-9,85), 5,20 (IC 95 %: 1,90-14,16) y 3,12 (IC 95 %: 1,07-9,04) veces mayor prevalencia del fenotipo MNS, respectivamente, que aquellas con adecuación de estos parámetros. El análisis de regresión logística binaria demostró que la edad es un predictor del fenotipo MUH (OR = 1,254; IC 95 %: 1,00-1,56) y esta variable mostró correlación con TG, VAI and A/G. No hubo asociación entre la tirotropina y el fenotipo MUH en la presente muestra. Conclusión: la edad y la adiposidad visceral son predictores del fenotipo MUH en practicantes de ER en la menopausia, que puede caracterizarse inicialmente alteraciones en el perfil plasmático de insípidos.

Abstract. Introduction : graduation in the health area should equally contemplate the psychomotor, cognitive and affective domains from the problematization of everyday situations of the Unified Health System (SUS). Objective : to evaluate the training of nutritionists based on the integration of knowledge from the teaching-service-community triad, based on Project-Based Learning (PBL) and Collective Portfolio (PC) in the micropolitics of the SUS. Method : a “baby shower” planned and executed by students, guided by a group of teachers, aimed at pregnant women in the SUS network, providing the live work of the concept-tools “alterity”, “bond”, “welcoming”, and “participatory management” was undertaken. Results : records in the CP showed articulation between different knowledge and learning domains in the training of nutritionists by skills. Conclusion: PBL+CP is a powerful and viable teaching-learning tool for the training of professionals capable of working in SUS integrating teachingservice-community.

Resumo Introdução : a formação na área de saúde deve contemplar equanimemente os domínios psicomotor, cognitivo e afetivo a partir da problematização de situações cotidianas do Sistema Único de Saúde (SUS). Objetivo : avaliar a formação do nutricionista a partir da integração de saberes da tríade ensino-serviço-comunidade, a partir da Aprendizagem Baseada em Projetos (ABP) e Portfólio Coletivo (PC) na micropolítica do SUS. Método : Um “chá de bebê” planejado e executado por estudantes, orientado por um grupo de docentes, destinado a gestantes da rede SUS, oportunizando o trabalho vivo dos conceitos-ferramentas ‘alteridade’, ‘vínculo’, ‘acolhimento’, e ‘gestão participativa’ foi empreendido. Resultados : Registros no PC evidenciaram articulação entre diferentes saberes e domínios de aprendizagem na formação do nutricionista por competências. Conclusão : ABP+PC é uma ferramenta de ensino-aprendizagem, potente e viável para a formação do profissional capaz de atuar no SUS integrando ensino-serviço-comunidade.

Abstract Brazil has a huge number of cases and deaths due to coronavirus disease 2019 (COVID-19); however, few studies have dealt with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among familial contacts in Brazil. Here, we report our findings on transmission in a family-based study in Bauru, São Paulo, Brazil. The study, conducted from July to November 2020, comprised 974 individuals with 233 index patients and 741 familial contacts. Familial contacts were evaluated using the rapid COVID-19 Ag ECO and reverse transcription-polymerase chain reaction (RT-PCR) tests immediately after the index patient diagnosis. The antigen-based rapid test was validated in 121 individuals using RT-PCR as the gold standard. Additionally, 30 days later, familial contacts were evaluated for IgM and IgG antibodies against SARS-CoV-2. We found 333 cases of COVID-19 among familial contacts (44.9%). A positive correlation was observed between the time elapsed from the onset of symptoms until the index patient’s COVID-19 testing and the number of family contacts infected by SARS-CoV-2. Early SARS-CoV-2 testing and familial contact evaluation are relevant strategies to contain transmission.

Resumo O Brasil apresenta um alto número de casos e óbitos por coronavírus (COVID-19), apesar disso, poucos estudos tratavam da infecção pelo coronavirus-2 causador de síndrome respiratória aguda grave (SARS-CoV-2) entre contatos familiares no Brasil. Relatamos aqui nossos achados sobre a transmissão de SARS-CoV-2 em um estudo de base familiar de Bauru, no estado de São Paulo, Brasil. O estudo foi realizado de julho a novembro de 2020 e compreendeu 974 indivíduos, sendo 233 pacientes índice e 741 contatos familiares. Os contatos familiares foram avaliados por meio do teste rápido COVID-19 Ag ECO Test e RT-PCR imediatamente após o diagnóstico do paciente índice. O uso do teste rápido baseado em antígeno foi validado em 121 indivíduos utilizando RT-PCR como padrão ouro. Adicionalmente, 30 dias após a avaliação inicial, os contatos familiares foram avaliados quanto à presença de anticorpos IgM e IgG contra SARS-CoV-2. Encontramos 333 casos de COVID-19 entre contatos familiares (44,9%). Observamos uma correlação positiva entre o tempo decorrido entre o início dos sintomas e o teste para COVID-19 do paciente índice e o número de contatos familiares infectados por SARS-CoV-2. A testagem precoce da infecção por SARS-CoV-2 e a avaliação de contatos familiares são estratégias relevantes para conter a transmissão.

ABSTRACT Objective: To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. Materials and methods: This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis model assessment (HOMA) – insulin resistance (IR) and HOMA-β indices and assessments of insulinemia and HbA1c levels. These parameters were analyzed with a T test by paired comparison of the means of the variables and Wilcoxon's test paired for the median; in the variables with an abnormal distribution, the Z score was generated for the mean in both the pretreatment and SVR periods. Statistical significance was considered at p ≤ 0.05. Results: Among 273 participants, 125 (45.8%) had prediabetes, and 50 (18.3%) had diabetes. In SVR, there was a significant increase in platelets, albumin, alkaline phosphatase, cholesterol and triglycerides and a significant decrease in aspartate aminotransferase, alanine aminotransferase, gamma GT and bilirubin. The HOMA-IR and HOMA-β indices increased in SVR from 1.95 to 2.29 (p = 0.087) and 71.20 to 82.60 (p = 0.001), respectively. Insulinemia increased from 7.60 μU/mL to 8.90 μU/mL (p = 0.011). HbA1c decreased from 5.6 to 5.4 (p < 0.001). Among patients with prediabetes and those with diabetes, the reduction in HbA1c values was significant (p = 0.006 and p = 0.026, respectively). Conclusion: SVR significantly impacts and leads to improvement in glucose metabolism in patients with chronic liver disease induced by hepatitis C virus.

Abstract Brazil has a huge number of cases and deaths due to coronavirus disease 2019 (COVID-19); however, few studies have dealt with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among familial contacts in Brazil. Here, we report our findings on transmission in a family-based study in Bauru, São Paulo, Brazil. The study, conducted from July to November 2020, comprised 974 individuals with 233 index patients and 741 familial contacts. Familial contacts were evaluated using the rapid COVID-19 Ag ECO and reverse transcription-polymerase chain reaction (RT-PCR) tests immediately after the index patient diagnosis. The antigen-based rapid test was validated in 121 individuals using RT-PCR as the gold standard. Additionally, 30 days later, familial contacts were evaluated for IgM and IgG antibodies against SARS-CoV-2. We found 333 cases of COVID-19 among familial contacts (44.9%). A positive correlation was observed between the time elapsed from the onset of symptoms until the index patient’s COVID-19 testing and the number of family contacts infected by SARS-CoV-2. Early SARS-CoV-2 testing and familial contact evaluation are relevant strategies to contain transmission.

Resumo O Brasil apresenta um alto número de casos e óbitos por coronavírus (COVID-19), apesar disso, poucos estudos tratavam da infecção pelo coronavirus-2 causador de síndrome respiratória aguda grave (SARS-CoV-2) entre contatos familiares no Brasil. Relatamos aqui nossos achados sobre a transmissão de SARS-CoV-2 em um estudo de base familiar de Bauru, no estado de São Paulo, Brasil. O estudo foi realizado de julho a novembro de 2020 e compreendeu 974 indivíduos, sendo 233 pacientes índice e 741 contatos familiares. Os contatos familiares foram avaliados por meio do teste rápido COVID-19 Ag ECO Test e RT-PCR imediatamente após o diagnóstico do paciente índice. O uso do teste rápido baseado em antígeno foi validado em 121 indivíduos utilizando RT-PCR como padrão ouro. Adicionalmente, 30 dias após a avaliação inicial, os contatos familiares foram avaliados quanto à presença de anticorpos IgM e IgG contra SARS-CoV-2. Encontramos 333 casos de COVID-19 entre contatos familiares (44,9%). Observamos uma correlação positiva entre o tempo decorrido entre o início dos sintomas e o teste para COVID-19 do paciente índice e o número de contatos familiares infectados por SARS-CoV-2. A testagem precoce da infecção por SARS-CoV-2 e a avaliação de contatos familiares são estratégias relevantes para conter a transmissão.

Abstract: #MeToo is one of the feminist movements driven by the digital and with glocal expression. Turned viral through Twitter, it quickly gained visibility in traditional media, bringing to the public sphere the discussion of topics related to sexual harassment and violence. Using the public expression of the #MeToo movement in the Portuguese traditional media between 2017 and 2022, and based on a qualitative methodology anchored in a thematic analysis of 91 opinion articles of the newspapers Expresso and Público, this paper aims to comprehend the particularities of the Portuguese context around #MeToo issues and analyze the themes that were highlighted in these spaces. Three major themes arise: Sexual Harassment and Violence; Questioning (re)victimization and normalization; Ambivalence of feminisms in the #MeToo movement. From our findings, the emergence of contradictory discourses about the movement that served to both discredit it and raise public awareness of the problems of sexual harassment and violence stands out. In conclusion, opinion articles have the power to both influence the crystallization of specific positions and the change of attitudes and behaviors in the public sphere due to the authority and legitimacy of those who write opinion pieces in the newspapers and have the ability to thematize the public sphere.

Resumo: O #MeToo é um dos movimentos feministas impulsionado pelo digital e com expressão glocal. Tornado viral através do Twitter, rapidamente ganhou visibilidade nos media tradicionais trazendo para a esfera pública a discussão de temas associados ao assédio e violência sexual. Tomando como ponto de partida a expressão pública nos media tradicionais do movimento #MeToo em Portugal entre 2017 e 2022, e com base numa metodologia qualitativa ancorada numa análise temática de 91 artigos de opinião dos jornais Expresso e Público, este artigo visa conhecer as especificidades do contexto português em torno das questões que envolvem o #MeToo e analisar as temáticas que foram evidenciadas nestes espaços. Ressalta-se o surgimento de três grandes temáticas: Assédio e Violência Sexual; Questionamento da (re)vitimização e normalização; Ambivalência dos feminismos no movimento #MeToo. Dos resultados, destaca-se a existência de discursos paradoxais sobre o movimento, os quais, por um lado, contribuem para a sua descredibilização, e, por outro, funcionam como motores para a consciencialização pública das questões da violência e do assédio. Concluímos que os artigos de opinião têm o poder de influência tanto na cristalização de determinadas posições, como na mudança de atitudes e comportamentos da esfera pública, sendo estes promovidos pela autoridade e legitimidade de quem faz opinião nos jornais e tem a capacidade para tematizar o espaço público.

Resumen: #MeToo es un movimiento feminista originado en la red de carácter glocal. Viralizado por Twitter, rápidamente ganó visibilidad en los medios de comunicación tradicionales, llevando a la esfera pública el debate sobre cuestiones relacionadas con el acoso y la violencia sexual. Tomando como punto de partida la presencia del movimiento #MeToo en los medios de comunicación en Portugal entre 2017 y 2022, y a partir de una metodología cualitativa centrada en un análisis temático de 91 artículos de opinión de los periódicos Expresso y Público, este artículo busca conocer las especificidades del contexto portugués en torno a las cuestiones que rodean al #MeToo y analizar los temas que se destacaron en estos espacios. Se remarca la existencia de tres temas principales: Acoso y Violencia Sexual; Cuestionamiento, (re)victimización y normalización de la violencia sexual; Posturas contradictorias ante el movimiento #MeToo. Los resultados muestran la existencia de discursos paradójicos en relación con el movimiento que contribuyen, por un lado, a su descrédito, pero, por otro, actúan como motores de la concientización pública en torno a la violencia y el acoso. Concluimos que los artículos de opinión tienen el poder de influir tanto en la cristalización de determinadas posiciones como en el cambio de actitudes y comportamientos en la esfera pública, siendo estos promovidos por la autoridad y la legitimidad de quienes opinan en los periódicos y tienen la capacidad de influir en la opinión pública.

Resumo A intervenção precoce centrada na família tem sido considerada entre os pesquisadores como o atual paradigma para o cuidado à infância. Este artigo tem por objetivo apresentar e discutir percepções de familiares sobre as práticas de intervenção precoce e participação ativa da família, realizadas pela equipe de um Centro Especializado de Reabilitação (CER) no atendimento de crianças com Transtorno do Espectro Autista (TEA). Participaram da pesquisa nove familiares de crianças com TEA, de zero a quatro anos e 11 meses, inseridas no serviço. Foram realizadas entrevistas com os participantes para investigar o conhecimento das famílias e suas expectativas sobre a participação nas intervenções, e após a coleta de dados foi feito a análise temática de conteúdo. A prática da equipe desse serviço não está relacionada exclusivamente a um único modelo de apoio às famílias, com a participação família sendo, em sua maioria, alinhada ao modelo de apoio focado na família. Espera-se que este estudo possa contribuir e fomentar discussões sobre a intervenção precoce, dos modelos de apoio à família, e em especial das crianças com TEA.

Abstract Family-centered early intervention has been considered by researchers as the current paradigm for childcare. This article aims to present and discuss perceptions of family members about early intervention practices and active family participation, carried out by the team of a Specialized Rehabilitation Center (CER) in the care of children with Autistic Spectrum Disorder (ASD). Nine family members of children with ASD, from zero to four years and 11 months, included in the service, participated in the research. Interviews were conducted with the participants to investigate the families’ knowledge and their expectations about participating in the interventions, and after data collection, thematic content analysis was performed. The practice of the team at this service is not exclusively related to a single model of support for families, with family participation being, for the most part, aligned with the support model focused on the family. It is hoped that this study can contribute and encourage discussions about early intervention, family support models, and especially children with ASD.

ABSTRACT Objective: to understand family relationships experienced in the context of marital violence. Method: a qualitative study that used the Constructivist Grounded Theory. The participants were 23 women, three of which were daughters of women experiencing marital violence. The data were collected from March to November 2021 by means of online interviews on the Facebook® and WhatsApp® social networks. The analytical process involved constant data comparison, in addition to initial and focused coding. Results: the central phenomenon, “Attributing meaning to family relationships in the context of marital violence”, and the “Distress experienced by mothers and daughters as a result of marital violence”, “Mobilizing to stop marital violence due to the daughters' distress” and “Mothers and daughters realizing the repercussions of marital violence experienced in the family relationship” processes reveal the impact of violence beyond women, also impacting the lives of their children. The pain and distress experienced, whether directly or indirectly, lasts over time, influencing the way in which family and social relationships are understood. Conclusion: marital violence was a process experienced by mothers and children, which mobilized the desire and actions to stop the problem. The meanings attributed to this experience are constructed, shared, elaborated and modified over time, but its repercussions persist with implications for the health and well-being of the victims: mothers and children.

RESUMEN Objetivo: comprender los vínculos familiares vivenciados en el contexto de violencia conyugal. Método: estudio cualitativo en el que se utilizó la vertiente constructivista de la Teoría Fundamentada en Datos. Las participantes fueron 23 mujeres, dos de las cuales eran hijas de madres en situación de violencia conyugal. Los datos se recolectaron entre marzo y noviembre de 2021 por medio entrevistas en línea en las redes sociales Facebook ® y WhatsApp ® . El proceso analítico implicó una comparación constante de los datos, además de los procesos de codificación inicial y focalizada. Resultados: el fenómeno central, “Atribuir significado a los vínculos familiares en el contexto de violencia conyugal”, y los procesos “Sufrimiento vivido por madres a hijas(os) a raíz de la violencia conyugal”, “Movilizarse para escapar de la violencia conyugal por el sufrimientos de las/los hijas(os)” y “Madres e hijas que perciben las repercusiones de la violencia conyugal sufrida en el vínculo familiar”, revelan el efecto de la violencia no solo en las mujeres, también con repercusiones en la vida de los hijos. El dolor y el sufrimiento vividos, ya sea directa o indirectamente, perduran en el tiempo, influenciando la forma en la atribuyen significados a sus vínculos familiares y sociales. Conclusión: la violencia conyugal fue un proceso vivido por madres e hijos, en el que estos últimos fueron los agentes movilizadores del deseo y las acciones para solucionar el problema. Los significados atribuidos a esta experiencia se construyen, comparten, elaboran y modifican con el transcurso del tiempo; sin embargo, sus repercusiones perduran con implicancias para la salud y el bienestar de las víctimas: madres e hijos.

RESUMO Objetivo: Compreender as relações familiares vivenciadas no contexto de violência conjugal. Método: Estudo qualitativo que utilizou a Teoria Fundamentada nos Dados vertente construtivista. Participaram 23 mulheres, das quais três eram filhas de mulheres em situação de violência conjugal. Os dados foram coletados no período de março a novembro de 2021, mediante entrevistas on-line nas redes sociais Facebook ® e WhatsApp ® . O processo analítico envolveu a comparação constante dos dados, além da codificação inicial e focalizada. Resultados: O fenômeno central “Significando as relações familiares no contexto de violência conjugal” e os processos “Sofrimento vivenciado por mães e filhas(os) a partir da violência conjugal”; “Mobilizando-se para o rompimento da violência conjugal pelo sofrimento das(os) filhas(os)”; e “Mães e filhas percebendo às repercussões da violência conjugal experienciada na relação familiar” revelam o impacto da violência para além das mulheres, repercutindo também na vida dos filhos. A dor e o sofrimento experienciados, direta ou indiretamente, perduram ao longo do tempo, influenciando no modo com que significam suas relações familiares e sociais. Conclusão: A violência conjugal foi um processo vivenciado por mães e filhos, sendo estes mobilizadores do desejo e ações de rompimento do agravo. Os significados atribuídos a esta vivência são construídos, compartilhados, elaborados e modificados ao longo do tempo, mas suas repercussões perduram com implicações à saúde e bem estar das vítimas: mães e filhos.

ABSTRACT Objective: To analyze the temperature curve of raw or pasteurized human milk exposed to different heating methods. Method: Experiments with volumes of 5 ml to 100 ml of human milk were carried out between 2016 and 2021 and analyzed according to the exposure time by different heating methods. Descriptive statistics included the calculation of means, medians, minimum and maximum values, measures of dispersion and standard deviation. Results: The thermal curve made it possible to identify the heating of human milk close to body temperature when subjected to a water bath and microwaves. Milk exposed to room temperature (21°C) was unable to reach this temperature. When heated in a water bath at 40°C, smaller volumes reached body temperature between 3 and 5 minutes, while in a microwave at 50% power, practically all volumes reached temperature. Conclusion: The temperature curves of raw or pasteurized human milk were constructed, and it was possible to verify its behavior using different heating methods for administering the food in a neonatal intensive care unit, considering the volume, type and time of heating and temperature.

RESUMEN Objetivo: Analizar la curva de temperatura de la leche humana cruda o pasteurizada expuesta a diferentes métodos de calentamiento. Método: Se realizaron experimentos con volúmenes de 5 ml a 100 ml de leche humana entre 2016 y 2021 y se analizaron en función del tiempo de exposición mediante diferentes métodos de calentamiento. La estadística descriptiva incluyó el cálculo de medias, medianas, valores mínimos y máximos, medidas de dispersión y desviación estándar. Resultados: La curva térmica permitió identificar el calentamiento de la leche humana próximo a la temperatura corporal cuando se sometió a baño maría y microondas. La leche expuesta a temperatura ambiente (21°C) fue incapaz de alcanzar esta temperatura. Cuando se calentó en un baño de agua a 40°C, los volúmenes más pequeños alcanzaron la temperatura corporal entre 3 y 5 minutos, mientras que en un microondas al 50% de potencia, prácticamente todos los volúmenes alcanzaron la temperatura. Conclusión: Se construyeron las curvas de temperatura de la leche humana cruda o pasteurizada y se pudo comprobar su comportamiento utilizando diferentes métodos de calentamiento para administrar el alimento en una unidad de cuidados intensivos neonatales, teniendo en cuenta el volumen, el tipo y el tiempo de calentamiento y la temperatura.

RESUMO Objetivo: Analisar a curva de temperatura do leite humano cru ou pasteurizado exposto a diferentes métodos de aquecimento. Método: Experimentos com volumes de 5 ml a 100 ml de leite humano foram realizados entre 2016 e 2021 e analisados segundo o tempo de exposição por diferentes métodos de aquecimento. A estatística descritiva incluiu o cálculo das médias, medianas, valores mínimos e máximos, medidas de dispersão e desvio padrão. Resultados: A curva térmica permitiu identificar o aquecimento do leite humano próximo da temperatura corporal quando submetidos a banho-maria e micro-ondas. O leite exposto à temperatura ambiente (21°C) não foi capaz de atingir tal temperatura. No aquecimento em banho-maria a 40°C, volumes menores alcançaram a temperatura corporal entre 3 e 5 minutos, enquanto em micro-ondas na potência de 50%, praticamente todos os volumes alcançaram essa temperatura. Conclusão: As curvas de temperatura do leite humano cru ou pasteurizado foram construídas, sendo possível verificar o seu comportamento mediante diferentes métodos de aquecimento para administração do alimento em unidade de terapia intensiva neonatal, considerando o volume, tipo e tempo de aquecimento e temperatura.

Abstract Background Cognitive impairment, anxiety, and depression are present in patients with heart failure (HF), but their mutual correlation in hospitalized patients is not well established. Objectives The aims of this study were to identify the presence of cognitive impairment and the most affected domain, to investigate possible associations of cognitive impairment with depression and/or anxiety, and to observe whether they correlated with occurrence of readmission within 30 days following hospital discharge. Methods This is a prospective observational study including patients with HF from a private hospital. Psychological distress and cognition were evaluated by the Hospital Anxiety and Depression Scale (HADS) and by the Mini Mental State Exam (MMSE), respectively. Clinical data were obtained from the medical record at the time of inclusion, and outpatient follow-up was performed 30 days after discharge via telephone calls. Results This study included 71 patients (83% men, 75 ± 11 years). Cognitive impairment was present in 53.5% of the patients, and recall memory was the most altered cognitive domain. The proportion of possible/probable anxiety and depression was 21.1% and 34.2% in patients with cognitive impairment, respectively. However, only depression demonstrated association with cognitive impairment (p = 0.018). Cognitive impairment, anxiety, and depression showed no relationship with the occurrence of readmission within 30 days. Conclusions Cognitive impairment and depressive symptoms are prevalent and associated, and recall memory was the most altered cognitive domain in patients hospitalized with HF. However, there was no relationship between these factors and readmission within 30 days.

Abstract Objective: To evaluate inactivated CoronaVac prime vaccination, antibody decay, booster dose, and safety in ANCA-Associated Vasculitis (AAV) patients. Methods: Fifty-three AAV patients and 106 Controls (CG) received CoronaVac on days: D0 (first dose), D28(second dose), and D210 (booster dose, 32 AAV: 32 CG). The primary outcome was immunogenicity after the second vaccine dose (day 69) assessed by Seroconversion Rates (SC) of anti-SARS-CoV-2 S1/S2 IgG and Neutralizing Antibodies (NAb). Secondary outcomes were safety, immunogenicity (D28/D240), 6-months antibody decay (D210) and the booster dose response (D240). Results: At D69 SC (65.1% vs. 96.8%, p = 0.0001), GMT (21.3 UA/mL vs. 67.7 UA/mL, p < 0.001) and NAb- positivity (53.7% vs. 80.6%, p = 0.001) were moderate but lower in naïve-AAV patients than CG. Patients without SC used more often IS (93.3% vs. 53.3%, p = 0.015), mycophenolate mofetil (20% vs. 0%, p = 0.037) and prednisone (60.0% vs. 28.6%, p = 0.057) than seroconverted. NAb negativity in AAV patients was associated with prednisone treatment (57.9% vs. 18.2%, p = 0.015) and IS (84.2% vs. 55.0%, p = 0.046). Logistic regression analysis models showed that only prednisone was associated with lower seroconversion (OR = 0.2, 0,95% CI 0.05–0.86, p = 0.030) and with lower NAb positivity (OR = 0.2, 0,95% CI 0.05–0.88, p = 0.034). After six months (D69–D210) a decrease in IgG positivity occurred in 32 AAV patients (15.7%, p = 0.074) and 32 CG (18.7%, p = 0.041). For the NAb positivity, the 6-month decrease was not significant (p = 0.114) whereas a major reduction occurred for CG (p < 0.001). A booster dose (D240) resulted in an increment in IgG-positivity (21.9%, p = 0.023) and NAb-positivity (34.4%, p = 0.006) in AAV patients. No moderate/severe adverse events attributable to the vaccine were observed. Conclusion: This study provides novel data on the excellent safety and moderate immunogenicity of CoronaVac in AAV patients. A six-month mild antibody waning was observed with a good response to the booster dose, although levels remained lower than CG (CoronavRheum-NCT04754698).

SUMMARY OBJECTIVE: The objective of this study, carried out at the university hospital of the Federal University of Rio Grande, was to assess whether the treatment of chronic hepatitis C with direct-acting antivirals and the sustained virological response will affect the metabolic influences of the hepatitis C virus and whether these effects will vary according to genotypes and virus load. METHODS: This is an intervention pre-post study, carried out from March 2018 to December 2019, evaluating 273 hepatitis C virus patients treated with direct-acting antivirals. Inclusion criteria included being monoinfected with hepatitis C virus and achieving sustained virological response . Exclusion criteria included the presence of decompensated cirrhosis or co-infected with hepatitis B virus or human immunodeficiency virus. Genotypes, genotype 1 subtypes, and hepatitis C virus viral load were analyzed. Glucose metabolism was evaluated by the Homeostasis Model Assessment-insulin resistance indices: Homeostasis Model Assessment-β, TyG, and HbA1c, measured at the beginning of treatment and in sustained virological response. Statistical analysis with a T test by paired comparison of the means of the variables in the pretreatment and in the sustained virological response. RESULTS: Homeostasis Model Assessment-insulin resistance analysis: there were no significant differences between pretreatment and sustained virological response. Homeostasis Model Assessment-β analysis: significant increase in genotype 1 patients (p<0.028). TyG index analysis: significant increase in genotype 1b (p<0.017), genotype 3 (p<0.024), and genotype non-1 with low viral load (p<0.039). HbA1c analysis: significant decrease in genotype 3 (p<0.001) and genotype non-1 patients with low viral load (p<0.005). CONCLUSION: We detected significant metabolic influences after sustained virological response: impairment in lipid profile and improvements in the glucose metabolism. We found significant differences in genotype dependence, genotype 1 subtypes, and viral load.