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Resumo Objetivo: Avaliar os parâmetros de saúde física e mental, de qualidade de vida relacionada à saúde (QVRS), em adolescentes com deficiência física matriculados em organização não governamental (ONG) esportiva vs. em adolescentes sem deficiência, durante a pandemia da doença do coronavírus 2019 (COVID-19). Métodos: Este estudo transversal incluiu 30 adolescentes com deficiência e 86 adolescentes sem deficiência que responderam a questionário online com dados sociodemográficos e informações de rotina de saúde autoavaliadas durante a quarentena da COVID-19. Versões validadas de autorrelato do Strengths and Difficulties Questionnaire (SDQ), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), Pittsburgh Sleep Quality Index (PSQI) e Pediatric Outcome Data Collection Instrument (PODCI) também foram aplicadas. Resultados: A mediana de problemas emocionais [4(0–10) vs. 5(0–10),p=0,018] e pró-social [7(0–10) vs. 9(3–10),p=0,006] foi menor em adolescentes com deficiência vs. adolescentes sem deficiência. Adolescentes com deficiência tiveram função global significantemente inferior [68(21–99) vs. 94(67–100),p <0,001] e pontuações de felicidade mais altas do PODCI [90(65–100) vs. 80(0–100),p=0,016] em comparação com o grupo sem deficiências. A análise de regressão logística demonstrou que a atividade física/semana (odds ratio — OR=1,03; intervalo de confiança — IC95%=1,01–1,05,p=0,002) foi maior nos adolescentes com deficiência. No entanto, atividades domésticas (OR=0,14; IC95%=0,04–0,43,p=0,001) e tempo de tela ≥3 horas/dia (OR=0,09; IC95%=0,02–0,38,p=0,001) foram menores nos adolescentes com deficiência. Conclusões: Os adolescentes com deficiência que frequentam uma organização não governamental (ONG) esportiva não tiveram maior risco de apresentar indicadores adversos à saúde; apesar de apresentarem função física reduzida, relataram mais atividade física, maior felicidade e menos tempo de tela em comparação com adolescentes sem deficiência durante a pandemia da COVID-19.

Abstract Objective: This study aimed to assess physical and mental health, and health-related quality of life (HRQL) parameters in adolescents with physical disabilities enrolled in a sports nongovernmental organization (NGO) versus adolescents without disabilities during coronavirus disease 2019 (COVID-19) pandemic. Methods: This cross-sectional study included 30 adolescents with disabilities and 86 adolescents without disabilities who responded to an online questionnaire with sociodemographic data and self-rated healthcare routine information during the COVID-19 quarantine. Validated self-report versions of the Strengths and Difficulties Questionnaire (SDQ), Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0), Pittsburgh Sleep Quality Index (PSQI), and Pediatric Outcome Data Collection Instrument (PODCI) were also applied. Results: The median of emotional [4 (0–10) vs. 5 (0–10), p=0.018] and prosocial [7 (0–10) vs. 9 (3–10), p=0.006] problems was lower in adolescents with disabilities versus adolescents without disabilities. Adolescents with disabilities had significantly lower global function [68 (21–99) vs. 94 (67–100), p<0.001] and higher happiness scores in the PODCI scale [90 (65–100) vs. 80 (0–100), p=0.016] compared to controls. Logistic regression analysis demonstrated that physical activity/week (OR=1.03; 95%CI 1.01–1.05, p=0.002) was higher in adolescents with disabilities compared to adolescents without disabilities. However, housework activities (OR=0.14; 95%CI 0.04–0.43, p=0.001) and screen time ≥3 h/day (OR=0.09; 95%CI 0.02–0.38, p=0.001) were lower in adolescents with disabilities compared to adolescents without disabilities. Conclusion: Adolescents with disabilities attending a sports NGO were not at higher risk of adverse health-related indicators; despite showing reduced physical function, they reported more physical activity, higher happiness, and less screen time compared to adolescents without disabilities during the COVID-19 pandemic.

https://doi.org/10.1590/1984-0462/2023/41/2021334

Emotional, hyperactivity and inattention problems in adolescents with immunocompromising chronic diseases during the COVID-19 pandemic
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Campos, Reinan T.

; Lindoso, Livia

; Sousa, Renan A. de

; Helito, Alberto C.

; Ihara, Bianca P.

; Strabelli, Claudia A.A.

; Paradelas, Levi M.V.

; Carneiro, Beatriz O.L.

; Cardoso, Maria Paula R.

; Souza, Jean Paulo V. de

; Freire, Marianna R. de M.

; Astley, Camilla

; Laurentino, Moisés F.

; Buscatti, Izabel M.

; Kozu, Katia

; Aikawa, Nadia E.

; Sallum, Adriana M.E.

; Ferreira, Juliana CO.

; Simon, Juliana R.

; Viana, Vivianne S.L.

; Queiroz, Ligia B.

; Gualano, Bruno

; Roschel, Hamilton

; Pereira, Rosa Maria R.

; Toma, Ricardo K.

; Watanabe, Andréia

; Grangeiro, Patricia M.

; Casella, Caio B.

; Farhat, Sylvia C.

; Polanczyk, Guilherme V.

; Campos, Lucia Maria A.

; Silva, Clovis A.

Clinics

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2023, Volume 78 elocation 100167

Abstract: En | Text: En | PDF: En

Abstract Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics.

https://doi.org/10.1016/j.clinsp.2023.100167

Physical and mental health impacts during COVID-19 quarantine in adolescents with preexisting chronic immunocompromised conditions
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Lindoso, Livia

; Astley, Camilla

; Queiroz, Ligia Bruni

; Gualano, Bruno

; Pereira, Rosa Maria Rodrigues

; Tannuri, Uenis

; Campos, Lúcia Maria Mattei de Arruda

; Lourenço, Benito

; Toma, Ricardo Katsuya

; Medeiros, Karina

; Watanabe, Andréia

; Grangeiro, Patricia Moreno

; Barros, Vera da Penha Martellini Ferrari Rego

; Casella, Caio Borba

; Farhat, Sylvia

; Polanczyk, Guilherme Vanoni

; Silva, Clovis Artur

Jornal de Pediatria

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jul 2022, Volume 98 N. 4 Pages 350 - 361

Abstract: En | Text: En | PDF: En

Abstract Objective: To evaluate physical and mental health indicators in adolescents with preexisting chronic immunocompromised conditions during coronavirus disease 2019 (COVID-19) quarantine. Methods: A cross-sectional study included 355 adolescents with chronic conditions and 111 healthy adolescents. An online self-rated survey was used to investigate socio-demographic features, healthcare routine, and the quarantine impact on physical and mental health. The validated self-reported version of the Strengths and Difficulties Questionnaire (SDQ) was also applied. Results: The median of age [14 (10–18) vs. 15 (10–18) years, p = 0.733] and frequencies of female (61% vs. 60%, p = 0.970) were similar between adolescents with preexisting chronic conditions and healthy adolescents during quarantine of COVID-19 pandemic. The frequencies of abnormal total difficulties score of SDQ were similar in patients and controls (30% vs. 31%, p = 0.775). Logistic regression analysis showed that being female (OR = 1.965; 95% CI = 1.091–3.541, p = 0.024), fear of underlying disease activity/complication (OR = 1.009; 95%CI = 1.001–1.018, p = 0.030) were associated with severe psychosocial dysfunction in adolescents with chronic conditions, whereas school homework (OR = 0.449; 95% CI = 0.206–0.981, p = 0.045) and physical activity (OR = 0.990; 95% CI = 0.981–0.999, p = 0.030) were protective factors. Further analysis of patients with chronic immunocompromised conditions and previous diagnosis of mental disorders (9%) compared with patients without diagnosis showed higher median of total difficulties score (p = 0.001), emotional (p = 0.005), conduct (p = 0.007), peer problems (p = 0.001) and hyperactivity (p = 0.034) in the former group. Conclusion: Adolescents with preexisting chronic immunocompromised conditions during COVID-19 quarantine were not at higher risk of adverse health indicators. Being female, fear of underlying disease activity/complication, and household members working outside of the home were relevant issues for adolescents with preexisting chronic conditions. This study reinforces the need to establish mental health strategies for teens with chronic conditions, particularly during the pandemic.

https://doi.org/10.1016/j.jped.2021.09.002

The influence of the pilates method on the quality of life of its practitioners: a systematic review
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Silveira, Fabrício Sette Abrantes

; Abrantes, Lívia Carvalho Sette

; Moreira, Osvaldo Costa

; Prado Júnior, Pedro Paulo do

; Camilo, Flávio de Jesus

; Aidar, Felipe José

; Pereira, Eveline Torres

Motricidade

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jun 2022, Volume 18 N. 1 Pages 98 - 119

Abstract: En | Text: En | PDF: En

ABSTRACT Created in Germany by Joseph Pilates in the 1920s, the Pilates Method (PM) uses exercises aiming to improve physical health and mental balance. The present work objective was to verify, through a systematic literature review without delineating languages and dates, the influence of PM on the quality of life (QoL) of its practitioners. Medline, Embase, Web of Science, Scopus, and Google Scholar databases were consulted. The articles were independently selected by two researchers, who also conducted the risk of bias assessment of the included articles. Were identified 2489 articles on the databases, of which 30 were included in the study synthesis. The practice of PM improves the QoL of its practitioners, providing enhanced functional capacity, pain relief, and improvement of emotional aspects in individuals of both sexes, different age groups, and different clinical contexts.

https://doi.org/10.6063/motricidade.25780

ANALYSIS OF HEALTHCARE ASSOCIATED AND HOSPITAL ACQUIRED INFECTIONS IN CRITICALLY ILL PATIENTS WITH CIRRHOSIS
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D’OLIVEIRA, Ricardo Azevedo Cruz

; PEREIRA, Lívia Carolina Dourado

; CODES, Liana

; ROCHA, Mário de Seixas

; BITTENCOURT, Paulo Lisboa

Arquivos de Gastroenterologia

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mar 2022, Volume 59 N. 1 Pages 102 - 109

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto As infecções bacterianas ocorrem em 43—59% dos pacientes cirróticos internados em unidade de terapia intensiva com impacto na morbimortalidade. Um aumento na frequência de bactérias multirresistentes e com resistência estendida foi descrito em infecções bacterianas em pacientes cirróticos, com um impacto adverso na sobrevida. Objetivo Caracterizar as infecções adquiridas na comunidade, relacionadas aos cuidados de saúde (RCS) e hospitalares em pacientes cirróticos e seu impacto na ocorrência de desfechos adversos. Métodos Este estudo incluiu todos os pacientes cirróticos internados em uma unidade de terapia intensiva especializada em doenças hepáticas e gastrointestinais no Brasil entre janeiro de 2012 e junho de 2018. A frequência e topografia das infecções foram avaliadas retrospectivamente, bem como a frequência de bactérias multirresistentes e resistência estendida, e seu impacto na ocorrência de lesão renal aguda, síndrome hepatorrenal, insuficiência hepática crônica agudizada, sepse e mortalidade. Resultados Um total de 374 infecções foram observadas e classificadas como infecções adquiridas na comunidade (22%), RCS (34%) e infecções hospitalares (44%). Oitenta e nove (54%) episódios de infecções hospitalares foram identificadas como segunda infecção. Peritonite bacteriana espontânea (32%) e infecção do trato urinário (23%) foram as infecções mais comuns. As infecções comprovadas por cultura foram positivas em 61% dos casos, principalmente ocasionadas por bactérias gram-negativas (73%). Lesão renal aguda, síndrome hepatorrenal e sepse foram observados respectivamente, em 48%, 15% e 53% dos casos. Bactérias multirresistentes e resistência estendida foram observadas respectivamente, em 35% e 16%, principalmente nos RCS (48% vs 26% em infecções adquiridas na comunidade, P=0,02) e infecções hospitalares (58% vs 26% em infecções adquiridas na comunidade, P=0,0009). Os resultados adversos foram observados com mais frequência em indivíduos com infecções nosocomiais em comparação com infecções relacionadas aos cuidados de saúde e comunitárias. Infecções hospitalares, RCS e ocorrência de uma segunda infecção foram independentemente associadas à mortalidade intra-hospitalar. Conclusão Infecções hospitalares, relacionadas aos cuidados de saúde e reinfecções estão cada vez mais associadas a bactérias multirresistentes e/ou resistência estendida e são preditores independentes de mortalidade intra-hospitalar. Seu reconhecimento e seleção adequada de regimes antibióticos empíricos apropriados são medidas importantes para reduzir a mortalidade intra-hospitalar.

ABSTRACT Background Bacterial infections occur in 43—59% of cirrhotic patients admitted to the intensive care unit with impact in morbidity and mortality. An increase in the frequency of multidrug-resistant (MDRO) and extensively drug-resistant (XDRO) organisms has been described in bacterial infections in cirrhotic patients with an adverse impact on survival. Objective To characterize community-acquired (CA), healthcare-associated (HCA), and hospital-acquired (HA) infections in cirrhotic patients and their impact in the occurrence of adverse outcomes. Methods This study included all cirrhotic patients admitted in an intensive care unit specialized in liver and gastrointestinal diseases in Brazil between January 2012 and June 2018. Frequency and topography of infections were retrospectively evaluated, as well as the frequency of MDRO and XDRO organisms, and their impact in occurrence of acute kidney injury, hepatorenal syndrome, acute-on-chronic liver failure, sepsis and mortality. Results A total of 374 infections were observed and classified as CA (22%), HCA (34%) and hospital-acquired (44%). Eighty-nine (54%) episodes of hospital-acquired infections were second infections. Spontaneous bacterial peritonitis (32%) and urinary tract infection (23%) were the most common infections. Culture-proven infections were positive in 61% of the cases, mainly gram-negative bacteria (73%). Acute kidney injury, hepatorenal syndrome and sepsis were observed, respectively, in 48%, 15% and 53% of the cases. MDRO and XDRO were seen, respectively, in 35% and 16%, mainly in HCA (48% vs 26% in CA infections, P=0.02) and hospital-acquired (58% vs 26% in CA infections, P=0.0009). Adverse outcomes were more frequently observed in subjects with hospital-acquired infections when compared to HCA and CA infections. Hospital-acquired, HCA and second infections were independently associated with in-hospital mortality. Conclusion Hospital-acquired, HCA and second infections are increasingly associated with either MDRO and/or XDRO and are independent predictors of in-hospital mortality. Their recognition and proper selection of appropriate empiric antibiotic regimens are important measures to reduce in-hospital mortality.

https://doi.org/10.1590/s0004-2803.202200001-18

Assessment of a digital game as a neuropsychological test for postoperative cognitive dysfunction
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Lucatelli, André

; Goulart, Ananaira Alves

; Silveira, Paulo Sergio Panse

; Siqueira, José de Oliveira

; Carmona, Maria José Carvalho

; Pereira, Valéria Fontenelle Angelim

; Valentin, Livia Stocco Sanches

; Vieira, Joaquim Edson

Brazilian Journal of Anesthesiology

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feb 2022, Volume 72 N. 1 Pages 7 - 12

Abstract: En | Text: En | PDF: En

Abstract Objective: Postoperative cognitive dysfunction may result from worsening in a condition of previous impairment. It causes greater difficulty in recovery, longer hospital stays, and consequent delay in returning to work activities. Digital games have a potential neuromodulatory and rehabilitation effect. In this study, a digital game was used as a neuropsychological test to assess postoperative cognitive dysfunction, with preoperative patient performance as control. Methods: It was a non-controlled study, with patients selected among candidates for elective non-cardiac surgery, evaluated in the preand postoperative periods. The digital game used has six phases developed to evaluate selective attention, alternating attention, visuoperception, inhibitory control, short-term memory, and long-term memory. The digital game takes about 25 minutes. Scores are the sum of correct answers in each cognitive domain. Statistical analysis compared these cognitive functions preand post-surgery using a generalized linear mixed model (ANCOVA). Results: Sixty patients were evaluated, 40% male and 60% female, with a mean age of 52.7 ± 13.5 years. Except for visuoperception, a reduction in post-surgery scores was found in all phases of the digital game. Conclusion: The digital game was able to detect decline in several cognitive functions postoperatively. As its completion is faster than in conventional tests on paper, this digital game may be a potentially recommended tool for assessing patients, especially the elderly and in the early postoperative period.

https://doi.org/10.1016/j.bjane.2021.06.025

Comparison of digital games as a cognitive function assessment tool for current standardized neuropsychological tests
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Goulart, Ananaira Alves

; Lucatelli, André

; Silveira, Paulo Sergio Panse

; Siqueira, José de Oliveira

; Pereira, Valéria Fontanelle Angelim

; Carmona, Maria José Carvalho

; Valentin, Livia Stocco Sanches

; Vieira, Joaquim Edson

Brazilian Journal of Anesthesiology

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feb 2022, Volume 72 N. 1 Pages 13 - 20

Abstract: En | Text: En | PDF: En

Abstract Objective: Cognitive dysfunction may occur postoperatively. Fast and efficient assessment of Postoperative Cognitive Dysfunction (POCD) can minimize loss of quality of life, and therefore, a study comparing a digital game with standard neuropsychological tests to assess executive, mnemonic, and attention functions to evaluate POCD seems to be relevant both for research and clinical practice. Methods: A battery of standardized tests and a digital game (MentalPlus®) were administered to 60 patients at the Central Institute of Hospital das Clínicas in São Paulo (36 women and 24 men), with ages between 29 and 82 years, preand post-surgery performed under anesthesia. Correlation and linear regression model were used to compare the scores obtained from the standardized tests to the scores of the six executive and cognitive functions evaluated by the game (shortand long-term memory, selective and alternating attention, inhibitory control, and visual perception). Results: After correlation analysis, a statistically significant result was found mainly for the correlation between the scores from the phase of the digital game assessing the visuoperception function and the scores from the A and B cards of the Stroop Test (p < 0.001, r = 0.99 and r = 0.64, respectively), and the scores from TMTA (p = 0.0046, r = 0.51). We also found a moderate correlation between the phase of the game assessing short-memory function and VVLT (p < 0.001, r = 0.41). No statistically significant correlations were found for the other functions assessed. Conclusion: The digital game provided scores in agreement with standardized tests for evaluating visual perception and possibly short-term memory cognitive functions. Further studies are necessary to verify the correlation of other phases of the digital game with standardized tests assessing cognitive functions.

https://doi.org/10.1016/j.bjane.2021.06.027

Ansiedade e depressão em profissionais de enfermagem de uma maternidade durante a pandemia de COVID-19
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Ribeiro, Camila Lima

; Maia, Ivana Cristina Vieira de Lima

; Pereira, Lívia de Paulo

; Santos, Vanessa da Frota

; Brasil, Raquel Ferreira Gomes

; Santos, Juliana Sampaio dos

; Cunha, Morgana Boaventura

; Vieira, Luiza Jane Eyre de Souza

Escola Anna Nery

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2022, Volume 26 N. spe elocation e20220041

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Estimar a prevalência de sintomas de ansiedade e depressão e seus fatores relacionados, entre os profissionais de enfermagem de uma maternidade, durante a pandemia de COVID-19. Método Estudo observacional, descritivo e transversal, realizado com 189 profissionais de enfermagem de uma maternidade de referência, em Fortaleza-Ceará. A coleta de dados ocorreu durante três meses − de agosto a outubro de 2020 −, e utilizou-se Formulário Sociodemográfico e Clínico e Escala Hospitalar de Ansiedade e Depressão. Os fatores relacionados para depressão ou ansiedade foram determinados pela análise bivariada, por meio do teste qui-quadrado (nominais) e Wilcoxon (numéricas), com significância de p<0,05. Resultados Estimou-se a prevalência de sintomatologia ansiosa e depressiva em 58,3% e 29,6% dos participantes, respectivamente. Cerca de 53,5% foram afastados por suspeita de COVID-19 e 58%, infectados pelo vírus. Observou-se que os profissionais que atuavam na emergência, clínica obstétrica e Unidade de Terapia Intensiva materna foram os mais expostos ao risco de ter depressão (p=0,01055). Conclusão e implicações para a prática Alta prevalência de sintomas de ansiedade e depressão entre os participantes, independentemente de estarem na linha de frente da pandemia ou não. A situação requer acolhimento às demandas da saúde mental.

ABSTRACT Objective To estimate the prevalence of anxiety and depression symptoms and their related factors among nursing professionals in a maternity hospital during the COVID-19 pandemic. Method Observational, descriptive and cross-sectional study carried out with 189 nursing professionals from a reference maternity hospital in Fortaleza-Ceará. Data collection took place over three months, from August to October 2020, using the Sociodemographic and Clinical Form and the Hospital Anxiety and Depression Scale. Factors related to depression or anxiety were determined by bivariate analysis using the chi-square (nominal) and Wilcoxon (numerical) tests, with a significance of p<0.05. Results The prevalence of anxious and depressive symptoms was estimated in 58.3% and 29.6% of the participants, respectively. About 53.5% were removed due to suspected COVID-19 and 58% were infected with the virus. It was observed that professionals who worked in the emergency, obstetric clinic and maternal Intensive Care Unit were the most exposed to the risk of having depression (p=0.01055). Conclusion and implications for practice High prevalence of anxiety and depression symptoms among participants, regardless of whether they are on the front lines of the pandemic or not. The situation requires meeting the demands of mental health.

RESUMEN Objetivo Estimar la prevalencia de síntomas de ansiedad y depresión y sus factores relacionados entre profesionales de enfermería en una maternidad durante la pandemia de COVID-19. Método Estudio observacional, descriptivo y transversal realizado con 189 profesionales de enfermería de una maternidad de referencia en Fortaleza-Ceará. La recolección de datos ocurrió durante tres meses, de agosto a octubre de 2020, utilizando el Formulario Sociodemográfico y Clínico y la Escala Hospitalaria de Ansiedad y Depresión. Los factores relacionados con la depresión o la ansiedad se determinaron mediante análisis bivariado mediante las pruebas de chi-cuadrado (nominal) y Wilcoxon (numérica), con una significancia de p<0,05. Resultados La prevalencia de síntomas ansiosos y depresivos se estimó en 58,3% y 29,6% de los participantes, respectivamente. Alrededor del 53,5% fueron retirados por sospecha de COVID-19 y el 58% estaban infectados con el virus. Se observó que los profesionales que actuaban en emergencia, clínica obstétrica y Unidad de Terapia Intensiva materna eran los más expuestos al riesgo de tener depresión (p=0,01055). Conclusión e implicaciones para la práctica Alta prevalencia de síntomas de ansiedad y depresión entre los participantes, independientemente de si están en la primera línea de la pandemia o no. La situación requiere atender las demandas de salud mental.

https://doi.org/10.1590/2177-9465-ean-2022-0041pt

HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2/Flair MRI sequences
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NORO, Fabio

; ALVES-LEON, Soniza Vieira

; FONTES-DANTAS, Fabricia Lima

; VALLE BAHIA, Paulo Roberto

; ANDREIUOLO, Rodrigo Ferrone

; RUEDA LOPES, Fernanda Cristina

; PEREIRA, Valeria Coelho Santa Rita

; ABI-HAILA, Livia de Almeida Afonso

; COUTINHO, Renan Amaral

; ARAUJO, Amanda Dutra de

; MARCHIORI, Edson

Arquivos de Neuro-Psiquiatria

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dec 2021, Volume 79 N. 12 Pages 1109 - 1115

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: A predisposição genética para a esclerose múltipla (EM) está associada a alelos HLA, principalmente o HLA-DRB1*15:01. Objetivo: Identificar associações entre lesões na ressonância magnética e características genéticas em uma coorte brasileira de pacientes com EM. Métodos: Estudamos retrospectivamente os dados de 95 pacientes consecutivos com EM. Dois observadores independentes que desconheciam os dados clínicos identificaram “black holes” e lesões realçadas pelo contraste nas sequências de ressonância magnética T1 e contaram e mediram as lesões nas sequências T2 e FLAIR (fluid attenuated inversion recovery). Os casos foram classificados de acordo com tamanho, número e volume da lesão. Os alelos HLA-DRB1, HLA-DQB1 e HLA-DQA1 e os polimorfismos de nucleotídeo único rs4774, rs3087456, rs6897932, rs731236 e rs1033182 foram identificados por amplificação de reação em cadeia da polimerase com iniciadores específicos de sequência usando o kit One Lambda Inc., Canoga Park, CA, EUA. Resultados: Os pacientes com alelo HLA-DQA1*04:01 apresentaram carga de lesão (ajustada para idade, sexo e duração da EM) acima da mediana em comparação com outros pacientes com demais alelos HLA-DQA1 (p=0,02). Não houve diferenças entre todos os outros alelos HLA e polimorfismos de nucleotídeo único e carga lesional. Conclusões: A correlação do alelo HLA-DQA1*04:01 com maior carga de lesão nas sequências de RM em T2 sugere que a presença desse alelo pode estar associada ao risco de maior gravidade da EM.

ABSTRACT Background: The genetic predisposition to multiple sclerosis (MS) is associated with HLA alleles, especially HLA-DRB1*15:01. Objective: To identify associations between findings in magnetic resonance imaging (MRI) and genetic features in a Brazilian cohort of patients with MS. Methods: We retrospectively studied data from 95 consecutive patients with MS. Two independent observers who were blinded to the clinical data identified black holes and enhanced lesions on T1 MRI sequences, and counted and measured contrast-enhanced lesions on T2 and Flair (fluid attenuation inversion recovery) sequences. Cases were classified according to lesion size, number, and volume. The HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles, and the rs4774, rs3087456, rs6897932, rs731236, and rs1033182 single nucleotide polymorphisms were identified by polymerase chain reaction amplification with sequence-specific primers using the One Lambda Inc. Kit, Canoga Park, CA, USA. Results: Patients with the HLA-DQA1*04:01 allele had lesion load (adjusted for age, sex, and MS duration) above median compared with patients with other HLA-DQA1 alleles (p=0.02). There were no differences among all the other HLA alleles and single nucleotide polymorphisms and lesion load. Conclusions: The correlation of the HLA-DQA1*04:01 allele with a higher lesion load on T2/Flair MRI sequences suggests that the presence of this allele is associated with the risk of greater MS severity.

https://doi.org/10.1590/0004-282x-anp-2020-0487 3 downloads

10.

Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine
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Helito, Alberto C.

; Lindoso, Livia

; Sieczkowska, Sofia M.

; Astley, Camilla

; Queiroz, Ligia B.

; Rose, Natalia

; Santos, Claudia Renata P.

; Bolzan, Thalis

; Peralta, Rita María I.A.

; Franco, Ruth R.

; Cominato, Louise

; Pereira, Rosa Maria R.

; Tannuri, Uenis

; Campos, Lucia Maria A.

; Lourenço, Benito

; Toma, Ricardo K.

; Medeiros, Karina

; Watanabe, Andréia

; Grangeiro, Patricia Moreno

; Farhat, Sylvia C.

; Casella, Caio B.

; Polanczyk, Guilherme V.

; Gualano, Bruno

; Silva, Clovis A.

; Sallum, Adriana M. E.

; Iraha, Amanda Y.

; Ihara, Bianca P.

; Mazzolani, Bruna C.

; Martinez, Claudia A.

; Strabelli, Claudia A. A.

; Fonseca, Claudia B.

; Lima, Dandara C. C.

; Setoue, Debora N. D.

; Roz, Deborah F. P.

; Smaira, Fabiana I.

; Roschel, Hamilton

; Miyatani, Helena T.

; Marques, Isabela G.

; Oba, Jane

; Ferreira, Juliana C. O.

; Simon, Juliana R.

; Kozu, Katia

; Saccani, Ligia P.

; Martiniano, Lorena V. M.

; Miranda, Luana C. A.

; Silva, Luiz E. V.

; Laurentino, Moisés F.

; Aikawa, Nadia E.

; Sakita, Neusa K.

; Tanigava, Nicolas Y.

; Pereira, Paulo R. A.

; Palmeira, Patrícia

; Angelo, Simone S.

; Lavorato, Sofia S. M.

; Bernardes, Tamires M.

; Franco, Tathiane C.

; Viana, Vivianne S. L.

; Barros, Vera P. M. F. R.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3501

Abstract: En | Text: En | PDF: En

OBJECTIVE: To assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI). RESULTS: The median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001). CONCLUSION: Self-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

https://doi.org/10.6061/clinics/2021/e3501

11.

Impacto das Mudanças Climáticas na Produtividade da Cana de Açúcar em Maceió
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Oliveira, Lívia Pilar Melo de

; Silva, Fabrício Daniel dos Santos

; Costa, Rafaela Lisboa

; Rocha Júnior, Rodrigo Lins da

; Gomes, Heliofábio Barros

; Pereira, Marcos Paulo Santos

; Monteiro, Leonardo Amaral

; Silva, Vicente de Paulo Rodrigues da

Revista Brasileira de Meteorologia

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dec 2020, Volume 35 N. spe Pages 969 - 980

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Neste estudo, um modelo de downscaling estatístico (MDE) baseado na metodologia de análogos foi usado para projetar padrões futuros de precipitação e temperatura na cidade de Maceió, litoral leste do Nordeste (9,7° S; 35,7° W; 64,5m), e avaliar seus impactos na produtividade da cana de açúcar. Dados observados históricos foram usados para o downscaling da precipitação e temperatura usando diferentes modelos climáticos globais (CanESM2, CNRM-CM5, IPSL-CM5A-MR, GFDL-ESM2M, MIROC-ESM, MPI-ESM-MR, e NorESM1-M) em relação ao período de referencia (1961-1990), e, em seguida, para cenários futuros de 2021 a 2080. Os dados foram analisados em decêndios, mesmo passo de tempo do modelo agrometeorológico usado para a cultura. Ao contrário do que se esperava, a combinação de redução das chuvas e aumento da evapotranspiração nos cenários futuros não diminuiu a estimativa da produtividade, com previsão de aumento. A este fato pode-se atribuir que a redução das chuvas previstas, mais acentuadas no período chuvoso, não serão decisivas para a diminuição da produtividade, pois na maioria dos modelos climáticos há previsão de aumento das chuvas no período seco de setembro a dezembro, crítico para o crescimento inicial da cultura, que tem calendário de plantio a partir do primeiro decêndio de setembro.

Abstract In this study, a statistical downscaling model (SDSM) based on the analogous methodology was used to project future patterns of precipitation and temperature in the city of Maceió, east coast of northeastern Brazil (9.7° S; 35.7° W; 64.5m), and to evaluate its impacts on sugar cane yield. Historical observed data were used for downscaling precipitation and temperature using different global climate models (CanESM2, CNRM-CM5, IPSL-CM5A-MR, GFDL-ESM2M, MIROC-ESM, MPI-ESM-MR, and NorESM1-M) in relation to the reference period (1961-1990), and then for future scenarios from 2021 to 2080. The data were analysed in a ten days period, the same time step as the agrometeorological model used for culture. Contrary to what was expected, the combination of reduced rainfall and increased evapotranspiration in future scenarios did not decrease the estimate of yield, with an increase forecast. This effect can be attributed to the fact that the reduction in predicted rainfall, which was more pronounced in the rainy season, was not decisive for the decrease in yield, since in most MCGs there is a forecast of increased rainfall in the dry period from September to December, which is crucial for the initial growth of the crop, which has a planting schedule from the first ten-day period of September.

https://doi.org/10.1590/0102-77863550107 419 downloads

12.

Comunicação e sociabilidade: perspectivas no campo da comunicação
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França, Vera

; Oliveira, Ana Karina

; Lima, Laura

; Simões, Paula

; Bassoli, Gáudio

; Sepulveda, Lucas Afonso

; Barroso, Lívia

; Lobato, Maíra

; Lopes, Suzana

; Afonso, Maria Lúcia

; Basílio, Paulo

; Bontempo, Clara

; Pereira, Samuel

Galáxia (São Paulo)

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aug 2020, N. 44 Pages 201 - 218

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste artigo é mapear autores e teorias utilizados como referência por pesquisadores da área de comunicação e sociabilidade no Brasil. O corpus selecionado inclui 98 artigos da Compós no período de 2006 a 2015, coletados do grupo de trabalho homônimo. Esses resultados integram uma pesquisa mais ampla que almeja identificar as teorias contemporâneas que sustentam o campo da comunicação no país. A análise destaca dois eixos centrais nos estudos inscritos nessa área: o próprio sujeito (a questão da subjetividade, da autonomia e da opressão); 2) a sociedade em que ele se inscreve (a sociedade capitalista, de classes, mas também a sociedade em rede formada pelos novos dispositivos tecnológicos).

Abstract The aim of this paper is to map authors and theories used as reference by researchers in the field of Communication and Sociability in Brazil. The selected corpus includes 98 articles from Compós during the period from 2006 to 2015, collected from the homonymous working group. These results integrate a broader research that aims to identify the contemporary theories that underpin the field of Communication in the country. The analysis highlights two central axes in the studies regarded in this area: the subject itself (the question of subjectivity, autonomy and oppression); the society in which it is inscribed (capitalist society, society of classes, but also the network society formed by the new technological devices).

https://doi.org/10.1590/1982-25532020244989 690 downloads

13.

Financial impact of the change in the vulnerability profile of More Doctors Program
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Cavalcante, Denise de Fátima Barros

; Domingues, Carolina Vitti

; Meloni, Diego Roberto

; Almeida, Frederico Machado de

; Probst, Livia Fernandes

; Cavalcanti, Yuri Wanderley

; Meneghim, Marcelo de Castro

; Pereira, Antonio Carlos

Revista de Saúde Pública

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2020, Volume 54 elocation 148

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Calcular o fluxo de profissionais e o impacto financeiro do Projeto Mais Médicos para o Brasil (PMMB), dentro do Programa Mais Médicos (PMM), para o Ministério da Saúde e os municípios do estado de São Paulo aderentes, no período de janeiro de 2019 a março de 2022. MÉTODOS Realizou-se estudo de impacto financeiro a partir de bases de dados secundários públicos do estado de São Paulo. O número de vagas do PMMB por município, de médicos do projeto e os perfis de vulnerabilidade foram descritos para dimensionar a perda de reposição de profissionais no período. RESULTADOS No intervalo de tempo especificado, o número de médicos do PMMB em cidades a ele aderentes passará de 2.533 para 320, e o número de municípios participantes de 373 para 86. O impacto orçamentário para os municípios que necessitarão repor médicos será de R$ 929.487.904,77 (com análise de sensibilidade variando de R$ 650.641.533,34 a R$ 1.208.334.276,20). CONCLUSÃO A mudança de metodologia da vulnerabilidade adotada para o PMMB trará sérias consequências, ou seja, desassistência da população e alto impacto financeiro para os municípios do estado de São Paulo em um cenário de limitações orçamentárias.

ABSTRACT OBJECTIVE To estimate the flow of professionals and the financial impact of the Programa Mais Médicos para o Brasil (PMMB – More Doctors for Brazil Program) within the More Doctors Program (MDP) for the Brazilian Ministry of Health and the participating municipalities of the state of São Paulo, from January 2019 to March 2022. METHODS A financial impact study was conducted in the state of São Paulo based on public secondary databases. The number of PMMB vacancies per municipality, of physicians and vulnerability profiles were described to measure the loss of replacement of professionals in the period. RESULTS In the specified period, the number of PMMB physicians in participating cities will decrease from 2,533 to 320, and the number of participating municipalities from 373 to 86. The municipalities that will need to replace the physicians will have a financial impact of R$ 929,487,904.77 (with sensitivity analysis, ranging from R$ 650,641,533.34 to R$ 1,208,334,276.20). CONCLUSION The change of vulnerability methodology adopted for the PMMB will represent serious consequences, that is, less population assistance and high financial impact for the municipalities of the state of São Paulo in a scenario of budget limitations.

https://doi.org/10.11606/s1518-8787.2020054002156 208 downloads

14.

Financial impact of the change in the vulnerability profile of More Doctors Program
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Cavalcante, Denise de Fátima Barros

; Domingues, Carolina Vitti

; Meloni, Diego Roberto

; Almeida, Frederico Machado de

; Probst, Livia Fernandes

; Cavalcanti, Yuri Wanderley

; Meneghim, Marcelo de Castro

; Pereira, Antonio Carlos

Revista de Saúde Pública

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2020, Volume 54 elocation 148

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2020054002156

15.

A TRADUÇÃO CRIATIVA DE PAULO LEMINSKI DO CARPE DIEM HORACIANO
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Pereira, Lívia Mendes

Cadernos de Tradução

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aug 2019, Volume 39 N. 2 Pages 71 - 94

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O presente trabalho estuda e divulga o “projeto tradutório” do poeta e tradutor curitibano Paulo Leminski, com enfoque nas traduções que este realizou de textos da tradição greco-romana. Como pode ser constatado na leitura de sua biografia e como pode ser recorrentemente percebido nos temas que frequentam sua obra, o autor foi um conhecedor e divulgador da Língua e da Literatura Latina. Estudado inicialmente no mosteiro São Bento, na cidade de São Paulo, esse idioma antigo constituiu uma importante fonte criativa revisitada e repensada durante toda sua carreira literária. Além de traduções feitas diretamente do Latim como as da Ode I, 11, de Horácio (1984), e do Satyricon, de Petrônio (1985), o trabalho com textos literários latinos também pode ser encontrado em obras como Metaformose e Catatau. Neste estudo, daremos uma atenção especial à tradução realizada por Leminski da ode Horaciana em seu diálogo com a tradução do mesmo poema realizada por seu amigo e principal referencial teórico, o poeta Augusto de Campos. Destacaremos, portanto, as principais características de cada tradução e as coincidências e diferenças existentes entre elas, pautando-nos na teoria da tradução como recriação, advinda dos ideais poundianos do make it new.

Abstract The present work studies and disseminates the “translation project” of the poet and translator from Curitiba Paulo Leminski, with a focus on the translations that he made of the Greco-Roman texts tradition. It can be seen in the reading of his biography and it can be often perceived in the subjects which attend his work that the author was a knower and disseminator of the Latin Language and Literature. Originally studied by the author at the São Bento monastery located in the city of São Paulo, this ancient language was an important creative source revisited and rethought throughout his literary career. In addition to translations made directly from Latin, such as Ode I, 11, by Horace (1984) and Petronius’s Satyricon (1985), the work with Latin literary texts can also be found in pieces as Metaformose and Catatau. In this study, we will pay special attention to the translation made by the poet of Horaces’s Ode in its dialogue with the translation of the same poem by his friend and main theoretical reference, the poet Augusto de Campos. We will therefore highlight the main characteristics of each translation and the coincidences and differences between them, guided by the theory of translation as recreation, derived from the poundian ideals of make it new.

https://doi.org/10.5007/2175-7968.2019v39n2p71 969 downloads

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