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Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

Tubular adenoma of the breast: radiological and ultrasound findings
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Rodrigues, Rodrigo Amaral

; Azevedo, Carmen Lúcia Arantes Pereira

; Djahjah, Maria Célia Resende

; Pereira, Talita Siemann Santos

Radiologia Brasileira

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oct 2018, Volume 51 N. 5 Pages 341 - 342

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0100-3984.2017.0012 7371 downloads

Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil
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Alvarado-Arnez, Lucia Elena

; Batista, Angelica Martins

; Alves, Silvia Marinho

; Melo, Gloria

; Lorena, Virgínia Maria Barros de

; Cardoso, Cynthia C

; Pereira, Isabela Resende

; Carrazzone, Cristina

; Pacheco, Antonio G

; Oliveira Jr, Wilson

; Moraes, Milton Ozório

; Lannes-Vieira, Joseli

Memórias do Instituto Oswaldo Cruz

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2018, Volume 113 N. 6 elocation e170489

Abstract: En | Text: En | PDF: En

BACKGROUND The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes. OBJECTIVES We evaluated the association of 13 cytokine-related genes (TGFB: rs8179181, rs8105161, rs1800469; IL10: rs1800890, rs1800871, rs1800896; IFNG: rs2430561; TNF: rs1800629; BAT1: rs3853601; LTA: rs909253, rs2239704; TNFR1: rs767455; TNFR2: rs1061624) with risk and progression of CCC. FINDINGS Four hundred and six seropositive patients from CD endemic areas in the state of Pernambuco, north-eastern Brazil, were classified as non-cardiopathic (A, 110) or cardiopathic (mild, B1, 163; severe, C, 133). We found no evidence of TGFB, IL10, TNF, or TNFR1/2 gene polymorphisms associated with CCC risk or progression. Only BAT1 rs3853601 −22G carriers (B1 vs. C: OR = 0.5; p-value = 0.03) and IFNG rs2430561 +874AT (A vs. C: OR = 0.7; p-value = 0.03; A vs. B1+C: OR = 0.8; p-value = 0.02) showed a significant association with protection from cardiopathy in a logistic regression analysis with adjustment for gender and ethnicity; however, the association disappeared after performing adjustment for multiple testing. A systematic review of TNF rs1800629 −308G>A publications included five studies for meta-analysis (534 CCC and 472 asymptomatic patients) and showed no consensus in pooled odds ratio (OR) estimates for A allele or A carriers (OR = 1.4 and 1.5; p-values = 0.14 and 0.15, respectively). In CD patients, TNF serum levels were increased, but not affected by the TNF rs1800629 −308A allele. MAIN CONCLUSIONS Our data suggest no significant contribution of the analysed gene variants of cytokine-related molecules to development/severity of Chagas' heart disease, reinforcing the idea that parasite/host interplay is critical to CD outcomes.

https://doi.org/10.1590/0074-02760170489 1068 downloads

Economic values for milk production and quality traits in south and southeast regions of Brazil
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Cardoso, Vera Lucia

; Lima, Maria Lucia Pereira

; Nogueira, José Ramos

; Carneiro, Raul Lara Resende de

; Sesana, Roberta Cristina

; Oliveira, Elisa Junqueira

; El Faro, Lenira

Revista Brasileira de Zootecnia

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dec 2014, Volume 43 N. 12 Pages 636 - 642

Abstract: En | Text: En | PDF: En

The objective of this study was to calculate economic values for milk (MY), protein (PY) and fat productions (FY) and somatic cell count (SCC) which could be used to compose an economic index to rank animals involved in an international genetic evaluation program of Holstein cattle used in the commercial dairy population in Brazil. The main milk production systems (MPS) prevailing in the South and Southeast were defined based on the feeding management and production level of herds. To calculate feeding costs, energy requirements for the production of one kg of milk with the respective average protein and fat contents of each MPS were calculated. Feeding costs were obtained based on the regional prices of the diets' components. To calculate revenues, milk prices were obtained from the payment tables practiced by seven milk industries. Economic values were calculated from the marginal differences between revenues and costs, for the interest of maximizing the profit, assuming a fixed number of animals in the herd. The average economic values (R$) for MY, PY and FY were 0.51, 6.41 and 1.94, respectively. The economic impact of increasing the original SCC values in the individual records of cows in the population by 1% was -R$ 1.40 per cow, per year. Due to changes observed in the last years in the milk market in Brazil, selection for milk components became economically advantageous. As a result, the calculation of economic values and the proposition of an economic index based on these traits became feasible. Somatic cell count does have an economic impact on the final price of milk and consequently on the annual profit of herds. It has also been used in breeding programs as an indicator of mastitis resistance and should not be neglected in breeding programs of dairy cattle.

https://doi.org/10.1590/S1516-35982014001200002 4771 downloads

Avaliação da qualidade de vida com o instrumento SF-36 em lombalgia crônica
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Adorno, Marta Lúcia Guimarães Resende

; Brasil-Neto, Joaquim Pereira

Acta Ortopédica Brasileira

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aug 2013, Volume 21 N. 4 Pages 202 - 207

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar a qualidade de vida através dos domínios do Instrumento SF-36 em portadores de lombalgia crônica inespecífica. MÉTODOS: Trinta portadores de lombalgia crônica inespecífica foram aleatorizados para três grupos (grupo Iso (Isostretching), grupo RPG (Reeducação Postural Global) e Iso+RPG), e avaliados quanto à dor e qualidade de vida antes e após as intervenções fisioterápicas e reavaliados novamente após 2 meses de acompanhamento. Após a aceitação do Termo de Consentimento Livre e Esclarecido os pacientes foram submetidos a procedimentos como: avaliação fisioterápica através do Instrumento de Avaliação da Coluna Vertebral, Escala Visual Analógica de Dor (EVA), Questionário de Qualidade de Vida através do Instrumento SF-36, antes da 1ª sessão e após três meses de tratamento, e reavaliados 2 meses após o tratamento. RESULTADOS: Mostraram que ambas as técnicas fisioterápicas diminuíram a dor (p<0,001), porém quando foram associadas as duas técnicas (Iso + RPG) a melhora da dor foi significativamente maior, e na avaliação após dois meses de acompanhamento o método de RPG foi mais eficaz. Quanto à avaliação da qualidade de vida, as técnicas fisioterápicas foram eficazes após as intervenções (P<0,001), porém o método do Iso foi mais eficaz quando os pacientes foram reavaliados no acompanhamento. CONCLUSÃO: As técnicas fisioterápicas utilizadas neste estudo foram eficazes para tratar a lombalgia crônica inespecífica apresentada pelos pacientes, pois diminuíram a algia que os mesmos apresentavam e melhoraram a qualidade de vida segundo os domínios do Instrumento SF-36. Nível de Evidência II, Ensaio Clínico Controlado e Randomizado.

OBJECTIVE: To evaluate the quality of life (QOL) through the SF-36 Questionnaire in patients with chronic nonspecific low back pain (CNLBP). METHODS: Thirty patients with CNLBP were randomly assigned to one of three groups (Iso group (Isostretching), GPR group (Global Postural Reeducation), and the Iso+GPR group. Patients underwent physical therapy assessment with the use of the Vertebral Spine Assessment, the Visual Analog Scale of Pain (VASP), and the SF-36 quality of life questionnaire before the first session (first assessment), after three months of treatment (second assessment) and reassessed two months after the final session in the follow-up (third assessment). RESULTS: Both physical therapy techniques reduced pain (p<0.001); when the techniques (Iso+GPR) were combined, the reduction in pain was significantly greater; and, in the follow-up assessment, the GPR method was more efficient. As for the QOL, physical therapy techniques were effective after the interventions (p<0.001), and the Iso method was more effective when patients were reassessed in the follow-up. CONCLUSION: The physical therapy techniques used in this study were efficient to treat CNLBP in the patients since they reduced pain and increased QL according to the results of the SF-36 questionnaire. Evidence Level II, Randomized Controlled Clinical Trial.

45207 downloads

Vacas lactantes alimentadas com silagem de cana-de-açúcar com e sem aditivo bacteriano: consumo, digestibilidade, produção e composição do leite
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Santos, Alana Batista dos

; Pereira, Mara Lúcia Albuquerque

; Azevedo, Saulo Tannus

; Signoretti, Ricardo Dias

; Siqueira, Gustavo Resende

; Mendonça, Sandro de Souza

; Pires, Aureliano José Vieira

; Pereira, Taiala Cristina de Jesus

; Almeida, Paulo José Presídio

; Ribeiro, Leandro Sampaio Oliveira

; Pereira, César Augusto Ramos

Revista Brasileira de Saúde e Produção Animal

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sep 2012, Volume 13 N. 3 Pages 720 - 731

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A ensilagem de cana-de-açúcar é uma ferramenta que pode ser utilizada para atender a deficiência de alimento em períodos seco do ano, e a adição de aditivos microbianos na ensilagem pode melhorar o perfil fermentativo e, consequentemente, seu valor alimentício. O objetivo com o presente trabalho foi avaliar o efeito da utilização da cana-de-açúcar fresca ou conservada, sob a forma de silagem, com ou sem aditivo microbiano, bem como verificar a influência da queima da cana em dietas de vacas lactantes sobre o consumo e digestibilidade aparente dos nutrientes, produção e composição do leite. Os animais foram distribuídos em um quadrado latino 5 x 5 para avaliar os efeitos da cana fresca e da silagem de cana sem Lactobacillus buchneri (SCSI); cana com L. buchneri (SCCI); cana queimada sem L. buchneri (SCQSI); cana queimada com L. buchneri (SCQCI). Vacas alimentadas com cana fresca apresentaram maiores consumo de matéria seca e carboidratos não fibrosos, quando comparada com as silagens. A queima da cana e a conservação na forma de silagem, com ou sem aditivo microbiano, não alterou os consumos de matéria orgânica, proteína bruta, extrato etéreo, fibra em detergente neutro, fibra em detergente ácido, carboidratos totais, assim como, não influenciou a digestibilidade dos nutrientes dos animais. Ao alimentar vaca com silagem de cana sem aditivo bacteriano, observou-se menor produção de leite e de proteína bruta, quando comparado com as silagens queimadas com ou sem aditivo e cana fresca. Recomenda-se a utilização de cana fresca por proporcionar aos animais melhor desempenho produtivo.

The silage, sugar cane is a tool that can be used to meet the deficiency of food in the dry year and the addition of microbial silage additives can improve the fermentation and consequently, its food value. The objective was to evaluate the effect of the fresh sugar cane utilization or preserved as silage, with or without microbial addictive, as well as verify the influence of burning sugar cane used in diet crossbred dairy cows on intake and digestibility nutrients, production, milk composition. The animals were divided in a 5x5 latin square to evaluate the effects of fresh cane and four types of cane silage; cane without Lactobacillus buchneri (SCSI); cane with L.buchneri (SCCI); burned cane without L. buchneri (SCQSI); burned cane with L. buchneri (SCQCI). The fresh cane promotes higher dry matter intake and non-fibrous carbohydrates compared with silages. The burning of sugar cane and conservation as silage, with or without microbial additive does not alter the intake and digestibility of nutrients from animals. The use of cane ensilage without bacterial addictive provides lower milk production and crude protein when compared with the other treatments. It is recommended the use of fresh cane for providing animal better performance.

2038 downloads

Estéreo bovino líquido em luvissolo sódico: II. Emergência e análise de crescimento do maracujazeiro amarelo¹
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Batista Campos, Vinícius

; Ferreira Cavalcante, Lourival

; da Silva Prazeres-Campos, Stella

; Raj Gheyi, Hans

; Garófalo Chaves, Lúcia Helena

; Resende Pereira Junior, Lécio

Idesia (Arica)

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dec 2011, Volume 29 N. 3 Pages 17 - 24

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

An experiment was carried out in green house in order to evaluate at initial growth of yellow passion plants submitted to application of liquid bovine biofertilizer applied to soil in liquid form to levels equivalent to 0, 25, 50, 15 and 100% in volume corresponding to 10% (250 mL) of volume of the substrate and plant evaluation at five ages 45, 60, 15, 90 and 105 days after sowing. The supply of biofertilizer was applied in two epochs. The first 30 days the before the sowing followed by soil washing two days after application of biofertilizer and the second 48 hours before sowing and soil washing. The plants were irrigated with non saline water (EC = 0.21 dS m-1) adding water volume equivalent to evapotranspirat during 24 hours. The emergence of yellow passion fruit plants was superior in treatments with higher levels of biofertilizer applied to soil, over there of organic product provide more absolute growth rate of plants.

Um experimento foi desenvolvido em casa de vegetação em blocos em parcelas subdivididas com objetivo de avaliar a emergência e análise de crescimento do maracujazeiro amarelo num solo sódico submetido à aplicação de biofertilizante bovino líquido aplicado ao solo aos níveis percentuais de 0, 25, 50, 15 e 100% em volume correspondente a 10% (250 mL) do volume do substrato para avaliação das plantas aos 45, 60, 15, 90 e 105 dias após a semeadura. O fornecimento do biofertilizante foi realizado em duas etapas: a primeira aos 30 dias antes da semeadura mais lavagem dois dias após a aplicação e a segunda 48 horas antes da semeadura procedendo a lavagem semelhante a primeira aplicação. As plantas foram irrigadas com água não salina (CE= 0,21 dS m-1) fornecendo o volume de água evapotranspirado de cada 24 horas com base no processo de pesagem. O desbaste das plántulas foi realizado aos 28 dias após a semeadura deixando-se apenas uma planta por unidade experimental. O percentual de emergência do maracujazeiro amarelo foi superior nos tratamentos com maior percentagem de biofertilizante adicionado, além do insumo proporcionar maior taxa de crescimento absoluto das plantas.

1594 downloads Cited 1 time in SciELO

Candidiasis in pediatric patients with cancer interned in a university hospital
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Parahym, Ana Maria Rabelo De Carvalho

; Melo, Luciana Resende Bandeira de

; Morais, Vera Lúcia Lins De

; Neves, Rejane Pereira

Brazilian Journal of Microbiology

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jun 2009, Volume 40 N. 2 Pages 321 - 324

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os fungos são causas comuns de infecções em pacientes imunocomprometidos e espécies de Candida são freqüentemente envolvidas nesses casos. A fim de investigar infecção fúngica em pacientes pediátricos com câncer, amostras clínicas foram coletadas de cento e vinte dois pacientes internados no Hospital Universitário Oswaldo Cruz em Recife, Brasil. Leveduras foram isoladas de trinta e quatro amostras clínicas. As leveduras isoladas foram: Candida albicans (catorze isolados), C. parapsilosis (nove isolados), C. guilliermondii (dois isolados) e C. tropicalis (dois isolados). Descobrimos que candidemia foi mais freqüente em doentes com hematologias malignas e que C. parapsilosis apresentou maior mortalidade.

Fungi are common causes of infection in immunocompromised patients. Candida species are frequently involved in these cases. In order to investigate candidiasis in pediatric patients with cancer, clinical samples were collected from one hundred and twenty two patients interned in the Oswaldo Cruz University Hospital in Recife, Brazil. Yeasts were isolated from thirty-four clinical samples. The species isolated were: Candida albicans (fourteen isolates), C. parapsilosis (nine isolates), C. guilliermondii (two isolates) and C. tropicalis (two isolates). We found that candidemia was most frequent in patients with malignant hematology and that C. parapsilosis infections caused the highest mortality.

3989 downloads

Regiões de segurança em lançamento de projéteis
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Pereira, Lúcia Resende

; Bonfim, Valdair

Revista Brasileira de Ensino de Física

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sep 2008, Volume 30 N. 3 Pages 3313.1 - 3313.8

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Nosso principal objetivo neste trabalho é a determinação de regiões de segurança em balística. Por região de segurança entendemos a região do espaço tridimensional que fica livre da ação de projéteis. A determinação da região de segurança será reduzida ao cálculo da envoltória de uma família de trajetórias, indexada segundo o ângulo de tiro.

Our main objective in this work is the determination of security regions in ballistics. By security region we understand the region of three-dimensional space that is free to the action of projectiles. The determination of the security region will be reduced to the calculation of the envelope of a family of trajectories, indexed according to the angle of shot.

4251 downloads

10.

Invasive Trichosporon cutaneum infection in an infant with wilms' tumor
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Carvalho, Ana Maria Rabelo de

; Melo, Luciana Resende Bandeira de

; Moraes, Vera Lúcia

; Neves, Rejane Pereira

Brazilian Journal of Microbiology

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mar 2008, Volume 39 N. 1 Pages 59 - 60

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As infecções fungicas estão sendo relatadas cada vez mais em pacientes imunocomprometidos. Neste estudo nós relatamos um caso de infecção sistêmica por Trichosporon cutaneum em um infante com tumor de Wilms. Esta é a primeira vez que uma infecção invasiva por T. cutaneum é relatada em paciente com tumor de Wilms.

Fungal infections are increasingly being reported in immuno-compromised patients. In this study we report a case of systemic Trichosporon cutaneum infection in an infant with Wilms' tumor. This is the first time that an invasive infection for T. cutaneum has been reported in a Wilms' tumor patient.

2584 downloads

11.

Determinação de inibidores da germinação no espermoderma de sementes de café (Coffea arabica L.)
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Pereira, Carlos Eduardo

; Von Pinho, Édila Vilela Resende

; Oliveira, Denilson Ferreira

; Kikuti, Ana Lúcia Pereira

Revista Brasileira de Sementes

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2002, Volume 24 N. 1 Pages 306 - 311

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Sementes de café apresentam germinação lenta, aumentando consequentemente o período de formação das mudas. A causa dessa germinação lenta, ainda não está elucidada. Aparentemente, a difusão de gases e da água tem papel secundário comparadas ao efeito de inibidores presentes. A presente pesquisa foi desenvolvida no Setor de Sementes do Departamento de Agricultura e no Laboratório de Química da Universidade Federal de Lavras. Em uma pesquisa preliminar, utilizando sementes de alface como indicadora de inibidores e extrato aquoso de espermoderma ("película prateada"), ficou evidenciada a presença de inibidores nesse tecido. Em uma segunda etapa o extrato aquoso da película prateada foi submetido a um fracionamento, em teste in vitro. Observou-se, por meio desse teste, que a fração ativa encontrava-se na fase metanólica, a qual foi concentrada sob vácuo e eluída através de coluna de sílica gel com metanol, água destilada e HCl 0,1M. Após concentração sob vácuo da fração ativa originou-se um sólido branco, que se mostrou homogêneo segundo análise por cromatografia em camada fina com placas de sílica gel. Por meio de análise de espectrometria de infravermelho, de massas e de ressonância magnética nuclear de ¹H e de 13C, atribuiu-se a tal sólido a estrutura da cafeína. Conclui-se que o espermoderma pode contribuir para a lenta germinação das sementes de café, possivelmente devido à presença de cafeína.

Coffee seeds present slow germination, increasing hence the period of formation of seedlings. The cause that slow germination is not elucidated yet. Apparently, the diffusion of gases and water has a secondary role as compared with the effect of inhibitors present. The present research work was developed in the Seed Sector of the Agriculture Department and in the Chemistry Department of the Universidade Federal de Lavras. In a previous research by utilizing lettuce seeds as an indicator of inhibitors and aqueous extract of spermoderm (silvery film), the presence of inhibitors in this tissue was evidenced. In a second step, the aqueous step of the silvery film was submitted to a fractionating, in vitro test. It was observed by means of that test, that the active fraction was in the methanol phase, which was concentrated under vacuum and eluted through gel silica column with methanol, distilled water and 0.1M HCl. After concentration under vacuum, of active fraction gave rised to a white solid, which showed itself homogenous according to the thin layer chromatography analysis with gel silica plates. By means of the infrared, mass and ¹H and 13C nuclear magnetic resonance spectrometry, the caffeine structure was ascribed to such a solid. It follows that spermoderm may contribute to the slow germination of coffee seeds, possibly due to the presence of caffeine.

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