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Abstract Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics.

https://doi.org/10.1016/j.clinsp.2023.100167

Cutaneous infection by Mycobacterium lentiflavum after subcutaneous injection of lipolytic formula,
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Mello, Renan Bernardes de

; Moreira, Dalton Nogueira

; Pereira, Ana Carolina Gomes

; Lustosa, Nicole Ramalho

Anais Brasileiros de Dermatologia

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aug 2020, Volume 95 N. 4 Pages 511 - 513

Abstract: En | Text: En | PDF: En

Abstract The incidence of nontuberculous mycobacterial infections is increasing worldwide; by 2017, more than 190 species and subspecies have been documented. Although classically associated with immunosuppression, the recognition of these etiological agents in diseases affecting immunocompetent individuals and in healthcare-associated infections, such as after surgical and cosmetic procedures, makes the study of the epidemiology and pathogenesis of these microorganisms relevant in medical practice. Mycobacterium lentiflavum is slow-growing and rarely affects the skin. A case of cutaneous mycobacteriosis caused by M. lentiflavum is reported in an immunocompetent patient after subcutaneous injection of a lipolytic compound, treated with clarithromycin and levofloxacin.

https://doi.org/10.1016/j.abd.2019.11.013 362 downloads

Body self-image disturbances in women with prolactinoma
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Pereira, Helen S.

; Naliato, Erika C.

; Moraes, Aline B.

; Gadelha, Monica R.

; Vieira Neto, Leonardo

; Almeida, Renan M.

; Nardi, Antonio E.

; Violante, Alice H.

Brazilian Journal of Psychiatry

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feb 2020, Volume 42 N. 1 Pages 33 - 39

Abstract: En | Text: En | PDF: En

Objective: To evaluate body dissatisfaction and distorted body self-image in women with prolactinoma. Methods: Body dissatisfaction and distorted body self-image were evaluated in 80 women with prolactinoma. All patients were in menacme, 34% had normal body mass index (BMI), and 66% were overweight. Most patients (56.2%) had normal prolactin (PRL) levels and no hyperprolactinemia symptoms (52.5%). The Body Shape Questionnaire (BSQ) was used to assess the patients’ dissatisfaction with and concern about their physical form, and the Stunkard Figure Rating Scale (FRS) was used to assess body dissatisfaction and distorted body self-image. The patients were divided according to PRL level (normal vs. elevated) and the presence or absence of prolactinoma symptoms. Results: The normal and elevated PRL groups had similar incidences of body dissatisfaction and distorted body self-image. However, symptomatic patients reported a higher incidence of dissatisfaction than asymptomatic patients. Distorted body self-image was less common among symptomatic patients. Conclusion: Symptomatic patients showed higher body dissatisfaction, but lower body self-image distortion. The presence of symptoms may have been responsible for increased body awareness. The perception of body shape could have triggered feelings of dissatisfaction compared to an ideal lean body. Therefore, a distorted body self-image might not necessarily result in body dissatisfaction in women with prolactinomas.

https://doi.org/10.1590/1516-4446-2018-0325 680 downloads

Effect of the Incorporation of Sugarcane Bagasse Biochar in Leaching and Bioavailability of Clomazone in Soil
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Silva, Marcos R. F. da

; Queiroz, Maria E. L. R. de

; Neves, Antônio A.

; Silva, Antônio A. da

; Oliveira, André F. de

; Oliveira, Renan L. de

; Azevedo, Mariane M.

; Pereira, Gustavo A. M.

Journal of the Brazilian Chemical Society

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nov 2019, Volume 30 N. 11 Pages 2386 - 2394

Abstract: En | Text: En | PDF: En

Clomazone exhibits high water solubility, low sorption in soil colloids, and therefore can leach and contaminate deep layers of soil profile and groundwater. In this work, the effect of the incorporation of sugarcane bagasse biochar in leaching and bioavailability of clomazone in red latosol was evaluated. Soil samples amended with 1% (m/m) biochar were placed in different depths (0-1, 0-2.5 and 0-5 cm) on the top of polyvinyl chloride (PVC) columns filled with soil. Clomazone-based herbicide was applied, and rainfall was simulated on top of the columns. A validated chromatographic method, together with a greenhouse bioassay, were used to quantify and to evaluate the mobility and availability of clomazone along the columns. The incorporation of sugarcane bagasse biochar in the superficial layers at the column tops increased herbicide sorption, reduced its leaching and bioavailability in soil and scaled down the environmental risk of clomazone avoiding contamination of underground aquifer reservoirs.

https://doi.org/10.21577/0103-5053.20190149 493 downloads

Raleio mecânico como alternativa no cultivo de pessegueiros
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Barreto, Caroline F.

; Ferreira, Letícia V.

; Navroski, Renan

; Pereira, José F. M.

; Antunes, Luis E. C.

Revista de Ciências Agrárias

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jun 2019, Volume 42 N. 2 Pages 221 - 230

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Nas principais regiões produtoras de pêssego, o raleio é executado de forma manual, exigindo elevada disponibilidade mão de obra e custo dessa prática. O raleio mecânico pode ser uma alternativa ao raleio manual de frutos. Deste modo, o objetivo deste trabalho foi avaliar a eficiência do raleio mecânico com distintos equipamentos em pessegueiros. O experimento consistiu dos seguintes tratamentos: raleio manual de frutos, raleio mecânico de flores com o equipamento Carpa Electro®, raleio mecânico de flores com o equipamento derriçadeira e raleio mecânico nos frutos com o equipamento derriçadeira. As variáveis avaliadas, a campo foram percentagem de queda de flores e frutos, frutificação efetiva, tempo de raleio, número de frutos por planta, massa média dos frutos e produção por planta. O raleio manual e o raleio mecânico de flores com o equipamento derriçadeira foram eficazes para aumentar a produção e o diâmetro dos frutos. O raleio mecânico de flores e frutos constituem-se como uma alternativa ao raleio manual de pessegueiros, devido à capacidade de remoção e a redução de tempo para a realização da pratica do raleio.

In the major peach producing regions, thinning is performed manually, this practice requires high labor availability and cost. Mechanical thinning may be an alternative to manual fruit thinning. In this way, the objective of this work was to evaluate the efficiency of mechanical thinning with different equipment hand conducted in peach trees. The experiment consisted of the following treatments: hand thinning, mechanical flower thinning with the Carpa Electro® equipment, mechanical flower thinning with the trimming equipment and mechanical thinning of the fruits with the trimming equipment. The variables evaluated in the field were percentage of flower and fruit removed, effective fruiting, thinning time, number of fruits per plant, average fruit mass and yield per plant. The hand thinning and mechanical thinning of the flowers with the trimming equipment are effective to increase the yield and fruit size =. Mechanical thinning of flowers and fruits is an alternative to the manual peach tree thinning, due to the capacity of flower and fruit fall and the reduction of the time to thinning perform practice.

https://doi.org/10.19084/rca.17178 520 downloads

Molecular detection of Mycoplasma suis in extensive pig production systems in the State of Maranhão, northeast Brazil
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Martins, Mickaellen Susanny dos Santos

; Silva, Lucas Diniz

; Miranda, Leandro Macêdo

; Lima, Cristian Alex Aquino

; Amaral, Renan Bressianini do

; Machado, Rosangela Zacarias

; André, Marcos Rogério

; Braga, Maria do Socorro Costa Oliveira

; Rosário, Carla Janaina Rebouças Marques do

; Melo, Ferdinan Almeida

; Pereira, José Gomes

Revista Brasileira de Parasitologia Veterinária

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apr 2019, Volume 28 N. 2 Pages 306 - 309

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Mycoplasma suis é uma bactéria que causa a hemoplasmose em suínos. Este agente é capaz de se aderir à superfície dos eritrócitos de suínos, ocasionando deformações estruturais nestas células. No Brasil, poucos são os relatos acerca do parasita, da infecção e de seus impactos econômicos nas esferas produtiva e sanitária. O objetivo deste estudo foi investigar, por meio da PCR em tempo real quantitativa (qPCR) baseada no gene 16S rRNA, a ocorrência de M. suis em 64 amostras de sangue de suínos de criações extensivas dos municípios de Itapecuru Mirim, Santa Rita e Rosário, localizados no estado do Maranhão. Foram obtidos um percentual de 82,3%, 65,2% e 25% de amostras positivas na qPCR para M. suis nos municípios de Itapecuru Mirim, Santa Rita e Rosário, respectivamente. Este estudo mostra que M. suis circula entre os suínos de criações extensivas no estado do Maranhão.

Abstract Mycoplasma suis is a bacterium that causes hemoplasmosis in pigs. This agent is capable of adhering to the surface of porcine erythrocytes, inducing structural changes on these cells. In Brazil, there are few reports about the disease, its causal agent, and the economic impact of this pathogen on pig production systems and farm sanitation. The present study aimed to investigate the occurrence of M. suis in extensive swine farms located in the counties of Itapecuru Mirim, Santa Rita and Rosario, State of Maranhão, northeast Brazil. For such purpose, 64 blood samples of pigs from these facilities were tested for M. suis using a 16S rRNA gene-based quantitative real-time PCR (qPCR); 82.3%, 65.2% and 25% of blood samples of swine from farms in the cities of Itapecuru Mirim, Santa Rita and Rosario were positive for M. suis by qPCR, respectively. This study shows, for the first time, that M. suis circulates in pig populations from the state of Maranhão, Northeast Brazil.

https://doi.org/10.1590/s1984-296120180099 636 downloads

Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis
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Marques, Vanessa Daccach

; Passos, Giordani Rodrigues dos

; Mendes, Maria Fernanda

; Callegaro, Dagoberto

; Lana-Peixoto, Marco Aurélio

; Comini-Frota, Elizabeth Regina

; Vasconcelos, Cláudia Cristina Ferreira

; Sato, Douglas Kazutoshi

; Ferreira, Maria Lúcia Brito

; Parolin, Mônica Koncke Fiuza

; Damasceno, Alfredo

; Grzesiuk, Anderson Kuntz

; Muniz, André

; Matta, André Palma da Cunha

; Oliveira, Bianca Etelvina Santos de

; Tauil, Carlos Bernardo

; Maciel, Damacio Ramón Kaimen

; Diniz, Denise Sisteroli

; Corrêa, Eber Castro

; Coronetti, Fernando

; Jorge, Frederico M. H.

; Sato, Henry Koiti

; Gonçalves, Marcus Vinícius Magno

; Sousa, Nise Alessandra de C.

; Nascimento, Osvaldo J. M.

; Gama, Paulo Diniz da

; Domingues, Renan

; Simm, Renata Faria

; Thomaz, Rodrigo Barbosa

; Morales, Rogério de Rizo

; Dias, Ronaldo Maciel

; Apóstolos-Pereira, Samira dos

; Machado, Suzana Costa Nunes

; Junqueira, Thiago de Faria

; Becker, Jefferson

Arquivos de Neuro-Psiquiatria

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aug 2018, Volume 76 N. 8 Pages 539 - 554

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O crescent arsenal terapêutico na esclerose múltipla (EM) tem permitido tratamentos mais efetivos e personalizados, mas a escolha e o manejo das terapias modificadoras da doença (TMDs) tem se tornado cada vez mais complexos. Neste contexto, especialistas do Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla e do Departamento Científico de Neuroimunologia da Academia Brasileira de Neurologia reuniram-se para estabelecer este Consenso Brasileiro para o Tratamento da EM, baseados no entendimento de que neurologistas devem ter a possibilidade de prescrever TMDs para EM de acordo com o que é melhor para cada paciente, com base em evidências e práticas atualizadas. Por meio deste documento, propomos recomendações práticas para o tratamento da EM, com foco principal na escolha e no manejo das TMDs, e revisamos os argumentos que embasam as estratégias de tratamento na EM.

ABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS.

https://doi.org/10.1590/0004-282x20180078 8891 downloads

Socioeconomic environment effect on inferential reasoning of Latin American students
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Flores-Mendoza, Carmen

; Saraiva, Renan Benigno

; Câmara, Gislene Clemente Vilela

; Lopes, Wilma M. Guimarães

; Passos, Ana P. Carvalho Pereira

; Gama, Ana Maria Valladão Pires

; Baumgartl, Viviane de Valladão Pires

; Rodrigues, Larissa Assunção

; Ardila, Ruben

; Rosas, Ricardo

; Gallegos, Miguel

; Reategui, Norma

Salud mental

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oct 2017, Volume 40 N. 5 Pages 183 - 190

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction Inferential reasoning (IR) is a major component of intelligence, which comprises many different cognitive processes such as perception, memory, and logic. Many studies have proposed that socioeconomic status (SES) has a negligible association with IR, but more recent findings suggest that they may have a higher association when evaluating group instead of individual SES. Objective The aim of this study is to test the effects of both individual (students) and group (schools) socioeconomic status on IR, comparing different countries of Latin America. Method The sample was composed of 2 358 students aged 14 and 15 years from 52 different schools (44% public) of five Latin American countries (Argentina, Brazil, Chile, Colombia, and Peru). Participants took part in an inferential reasoning test and answered a socioeconomic questionnaire. Results SES student showed a small positive correlation with IR (r = .10, p < .001), while SES school had a more pronounced effect on IR (F [2, 1944] = 74.68, p < .001, ηp2 = .07), with higher IR at schools with higher SES. A significant difference of IR between countries (F [4, 1976] = 20.68, p < .001, ηp2 = .04), was also found with Peru showing the highest mean. Peru was the country with the higher percentage of private schools in the present study. A multilevel model was fitted using individual and group SES as predictors. Discussion and conclusion Our findings showed that group SES have a higher predictive value of IR when compared to individual SES. This result suggests that individuals with low SES can benefit from studying on higher SES schools. Future research and the importance of public policies are discussed.

Resumen Introducción El razonamiento inferencial (IR) es un componente importante de la inteligencia que comprende diversos procesos cognitivos, como la percepción, la memoria y la lógica. Muchos estudios han propuesto que el nivel socioeconómico (NSE) tiene una baja asociación con IR, pero hallazgos más recientes sugieren que el NSE del grupo puede tener mayor asociación que el NSE individual con el IR. Objetivo El objetivo de este estudio es investigar los efectos del nivel socioeconómico individual (estudiantes) y de grupo (escuelas) sobre el IR, haciéndose comparaciones entre diferentes países de América Latina. Método La muestra estuvo compuesta por 2 358 estudiantes con edades comprendidas entre los 14 y los 15 años, de 52 escuelas diferentes (44% públicas), de cinco países de América Latina (Argentina, Brasil, Chile, Colombia y Perú). Los participantes fueron evaluados con una prueba de razonamiento inferencial y un cuestionario socioeconómico. Resultados El NSE individual mostró una pequeña correlación positiva con IR (r = .10 p < .001), mientras que el NSE de grupo tuvo un efecto más pronunciado sobre IR (F [2, 1944] = 74.68, p < .001, ηp2 = .07) con mayor IR en las escuelas con mayor NSE. También se encontró una diferencia significativa de IR entre los países (F [4, 1976] = 20.68, p < .001, ηp2 = .04), con un promedio más alto para Perú, el país con mayor número de escuelas particulares en el presente estudio. Se ajustó un modelo multinivel utilizando las variables principales. Discusión y conclusión Nuestros resultados demostraron que el NSE de grupo tiene un mayor valor predictivo de IR en comparación con el SES individual. Este resultado sugiere que los individuos con un nivel socioeconómico bajo pueden beneficiarse de estudiar en escuelas con SES superiores. Se discuten las futuras investigaciones y la importancia de las políticas públicas.

https://doi.org/10.17711/sm.0185-3325.2017.024 647 downloads

Performance of the fixed pressure valve with antisiphon device SPHERA® in the treatment of normal pressure hydrocephalus and prevention of overdrainage
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Pereira, Renan M.

; Suguimoto, Mariane T.

; Oliveira, Matheus F.

; Tornai, Juliana B.

; Amaral, Ricardo A.

; Teixeira, Manoel Jacobsen

; Pinto, Fernando Campos Gomes

Arquivos de Neuro-Psiquiatria

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jan 2016, Volume 74 N. 1 Pages 55 - 61

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A hidrocefalia de pressão normal (HPN) é caracterizada pela tríade de sintomas de apraxia de marcha, demência e incontinência urinária. O tratamento padrão é realizado através de implantação de derivação ventricular, porém várias complicações são frequentes, como a hiperdrenagem secundária ao efeito sifão. Este estudo avaliou o resultado da válvula SPHERA® no tratamento desses pacientes em comparação com um grupo controle (PS Medical®). 30 pacientes foram consecutivamente alocados em dois grupos de 15 e seguidos por 1 ano. Pacientes com a válvula SPHERA® tiveram o mesmo grau de melhora clínica em comparação ao grupo controle, no entanto as complicações diagnósticadas e sintomatologia secundária à hiperdrenagem foi significativamente inferior no grupo da válvula SPHERA® group, sugerindo-a como uma ferramenta segura e aplicável.

ABSTRACT Normal pressure hydrocephalus (NPH) is characterized by the triad of gait apraxia, dementia and urinary incontinence associated with ventriculomegaly and normal pressure of cerebrospinal fluid. Treatment is accomplished through the implantation of a ventricular shunt (VPS), however some complications are still frequent, like overdrainage due to siphon effect. This study analyses the performance of a valve with anti-siphon device (SPHERA®) in the treatment of patients with NPH and compares it with another group of patients with NPH who underwent the same procedure without anti-siphon mechanism (PS Medical® valve). 30 patients were consecutively enrolled in two groups with 15 patients each and followed clinically and radiologically for 1 year. Patients submitted to VPS with SPHERA® valve had the same clinical improvement as patients submitted to VPS with PS Medical®. However, complications and symptomatology due to overdrainage were significantly lower in SPHERA® group, suggesting it as a safe tool to treat NPH.

https://doi.org/10.1590/0004-282X20150190 2333 downloads

10.

Laticifer proteins from Plumeria pudica inhibit the inflammatory and nociceptive responses by decreasing the action of inflammatory mediators and pro-inflammatory cytokines
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Fernandes, Heliana B.

; Machado, Douglas L.

; Dias, Jordana M.

; Brito, Tarcisio V.

; Batista, Jalles A.

; Silva, Renan O.

; Pereira, Anna C.T.C.

; Ferreira, Gustavo P.

; Ramos, Marcio V.

; Medeiros, Jand-Venes R.

; Aragão, Karoline S.

; Ribeiro, Ronaldo A.

; Barbosa, André L.R.

; Oliveira, Jefferson S.

Revista Brasileira de Farmacognosia

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jun 2015, Volume 25 N. 3 Pages 269 - 277

Abstract: En | Text: En | PDF: En

AbstractSome publications have described the pharmacological properties of latices proteins. Thus, in the present study proteins from Plumeria pudica Jacq., Apocynaceae, latex were evaluated for anti-inflammatory and antinociceptive activities. Obtained data showed that an intraperitoneal administration of different doses of latex was able to reduce the paw edema induced by carrageenan in a dose-dependent manner (better dose 40 mg/kg; 72.7% inhibition at 3rd and 78.7% at 4th hour) and the edema induced by dextran (40 mg/kg; 51.5% inhibition at 30 min and 93.0% at 1st hour). Inhibition of edema induced by carrageenan was accompanied by a reduction of myeloperoxidase activity. Pre-treating animals with latex (40 mg/kg) also inhibited the paw edema induced by histamine, serotonin, bradykinin, prostaglandin E2, compound 48/80. Additionally, the latex (40 mg/kg) reduced the leukocyte peritoneal migration induced by carrageenan and this event was followed by reduction of IL-1β and TNF-α in peritoneal fluid. The latex-treatment (40 mg/kg) reduced the animal abdominal constrictions induced by acetic acid and the first phase on paw licking model induced by formalin. When latex was treated with heat (at 100 °C for 30 min), anti-edematogenic and myeloperoxidase activities were significantly reduced, indicating the involvement of heat-sensitive proteins on anti-inflammatory effect. Our results evidence that latex fluids are a source of proteins with pharmacological properties.

https://doi.org/10.1016/j.bjp.2015.05.003 1605 downloads

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