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au:PERES, ALEXANDRE DE PAULA

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Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil
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Peres, Stela Verzinhasse

; Arantes, Paola Engelmann

; Fagundes, Marcela de Araújo

; Ab’Saber, Alexandre Muxfeldt

; Gimenes, Daniel Luiz

; Curado, Maria Paula

; Vieira, René Aloisio da Costa

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230028

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: This study aimed to analyze the prognosis of women with breast cancer by molecular subtypes, sociodemographic variables, and clinical and treatment characteristics. Methods: This hospital-based retrospective cohort study analyzed 1,654 women over 18 years of age diagnosed with invasive breast cancer from 2000 to 2018. Data were extracted from Brazil’s Oncocenter Foundation of São Paulo. The variables analyzed were age, histology, molecular subtypes, clinical staging, treatment type, and diagnosis-to-treatment time. Cox regression analysis was applied to estimate death risk. Results: Women with HER-2-positive (nonluminal) and triple-negative molecular subtypes were more than twice more likely to be at risk of death, with adjusted hazard ratio — HRadj=2.30 (95% confidence interval — 95%CI 1.34–3.94) and HRadj=2.51 (95%CI 1.61–3.92), respectively. A delayed treatment associated with an advanced clinical stage at diagnosis increased fourfold the risk of death (HRadj=4.20 (95%CI 2.36–7.49). Conclusion: In summary, besides that interaction between advanced clinical stage and longer time between diagnosis and treatment, HER-2-positive (nonluminal) and triple-negative phenotypes were associated with a worse prognosis. Therefore, actions to reduce barriers in diagnosis and treatment can provide better outcome, even in aggressive phenotypes.

RESUMO Objetivo: O objetivo deste estudo foi analisar o prognóstico de mulheres com câncer de mama de acordo com os subtipos moleculares, variáveis sociodemográficas, características clínicas e de tratamento. Métodos: Este foi um estudo de coorte retrospectivo de base hospitalar. Foram analisadas 1.654 mulheres maiores de 18 anos diagnosticadas com câncer de mama invasivo entre 2000 a 2018. Os dados foram extraídos da Fundação Oncocentro de São Paulo, Brasil. As variáveis analisadas foram idade, histologia, subtipo moleculares, estadiamento clínico, tipo de tratamento e tempo entre o diagnóstico e tratamento. A análise de regressão de Cox foi aplicada para estimar o risco de morte. Resultados: As mulheres que apresentaram os subtipos moleculares HER-2-positivo (não luminal) e triplo negativo tiveram risco de morte quase duas vezes maior respectivamente, com razão de risco ajustada — HRaj=2,30 (intervalo de confiança de 95% — 95%IC 1,34–3,94) e HRaj=2,51 (95%IC 1,61–3,92). O atraso no tratamento associado ao avanço do estadiamento clínico ao diagnóstico aumentou em quatro vezes o risco de morte (HRaj=4,20 (IC95% 2,36–7,49). Conclusão: Os fenótipos HER-2-positivo (não luminal) e triplo negativo, além da interação entre estágio clínico avançado e maior tempo entre o diagnóstico e o tratamento, associaram-se a pior prognóstico. Assim, ações para reduzir as barreiras no diagnóstico e tratamento podem proporcionar melhores resultados, mesmo em fenótipos agressivos.

https://doi.org/10.1590/1980-549720230028

Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil
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Peres, Stela Verzinhasse

; Arantes, Paola Engelmann

; Fagundes, Marcela de Araújo

; Ab’Saber, Alexandre Muxfeldt

; Gimenes, Daniel Luiz

; Curado, Maria Paula

; Vieira, René Aloisio da Costa

Revista Brasileira de Epidemiologia

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2023, Volume 26 elocation e230028

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1980-549720230028

Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II
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Santos, Paulo Sergio Faro

; Melhado, Eliana Meire

; Kaup, Alexandre Ottoni

; Costa, Aline Turbino Neves Martins da

; Roesler, Célia Aparecida de Paula

; Piovesan, Élcio Juliato

; Sarmento, Elder Machado

; Theotonio, Giselle Oliveira Martins

; Campos, Henrique Carneiro de

; Fortini, Ida

; Souza, Jano Alves de

; Maciel Júnior, Jayme Antunes

; Segundo, João Batista Alves

; Carvalho, João José Freitas de

; Speziali, José Geraldo

; Calia, Leandro Cortoni

; Barea, Liselotte Menke

; Queiroz, Luiz Paulo

; Souza, Marcio Nattan Portes

; Figueiredo, Marcos Ravi Cerqueira Ferreira

; Costa, Maria Eduarda Nobre de Magalhães

; Peres, Mário Fernando Prieto

; Jurno, Mauro Eduardo

; Peixoto, Patrícia Machado

; Kowacs, Pedro André

; Rocha Filho, Pedro Augusto Sampaio

; Moreira Filho, Pedro Ferreira

; Silva Neto, Raimundo Pereira

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

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sep 2022, Volume 80 N. 9 Pages 953 - 969

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder. Objective The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience. Methods Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy. Results From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease. Conclusions Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.

Resumo Antecedentes Migrânea afeta um bilhão de pessoas em todo o mundo e mais de 30 milhões de brasileiros; além disso, é um distúrbio subdiagnosticado e subtratado. Objetivo Sabe-se sobre a necessidade de difundir o conhecimento sobre o tratamento profilático da migrânea; por isso, a Sociedade Brasileira de Cefaleias (SBCe) nomeou um comitê de autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da migrânea episódica com base em artigos da literatura mundial, assim como da experiência pessoal. Métodos As reuniões foram realizadas inteiramente online, com a participação de 12 grupos que revisaram e escreveram sobre as categorias farmacológicas dos medicamentos e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de medicamentos estudadas na parte II deste Consenso foram: anti-hipertensivos, inibidores seletivos de recaptação de serotonina, inibidores de recaptação de serotonina e noradrenalina, bloqueadores dos canais de cálcio, outros medicamentos e politerapia racional. Resultados Desta lista de medicamentos, apenas o candesartan foi estabelecido como eficaz no controle da migrânea episódica. Flunarizina, venlafaxina, duloxetina e pizotifeno foram definidos como provavelmente eficazes, enquanto lisinopril, enalapril, escitalopram, fluvoxamina, quetiapina, atorvastatina, sinvastatina, ciproheptadina e melatonina foram possivelmente eficazes na profilaxia da doença. Conclusões Apesar do esforço da comunidade científica em encontrarmedicamentos realmente eficazes no tratamento da migrânea, dado o grande número de medicamentos testados para este fim, ainda dispomos de poucas opções terapêuticas.

https://doi.org/10.1055/s-0042-1755320

Consensus of the Brazilian Headache Society (SBCe) for the Prophylactic Treatment of Episodic Migraine: part I
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Melhado, Eliana Meire

; Santos, Paulo Sergio Faro

; Kaup, Alexandre Ottoni

; Costa, Aline Turbino Neves Martins da

; Roesler, Célia Aparecida de Paula

; Piovesan, Élcio Juliato

; Sarmento, Elder Machado

; Theotonio, Giselle Oliveira Martins

; Campos, Henrique Carneiro de

; Fortini, Ida

; Souza, Jano Alves de

; Maciel Júnior, Jayme Antunes

; Segundo, João Batista Alves

; Carvalho, João José Freitas de

; Speziali, José Geraldo

; Calia, Leandro Cortoni

; Barea, Liselotte Menke

; Queiroz, Luiz Paulo

; Souza, Marcio Nattan Portes

; Figueiredo, Marcos Ravi Cerqueira Ferreira

; Costa, Maria Eduarda Nobre de Magalhães

; Peres, Mário Fernando Prieto

; Jurno, Mauro Eduardo

; Peixoto, Patrícia Machado

; Kowacs, Pedro André

; Rocha-Filho, Pedro Augusto Sampaio

; Moreira Filho, Pedro Ferreira

; Silva-Neto, Raimundo Pereira

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

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aug 2022, Volume 80 N. 8 Pages 845 - 861

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The Brazilian Headache Society (Sociedade Brasileira de Cefaleia, SBCe, in Portuguese) nominated a Committee of Authors with the aim of establishing a consensus with recommendations regarding prophylactic treatment for episodic migraine based on articles published in the worldwide literature, as well as personal experience. Migraine affects 1 billion people around the world and more than 30 million Brazilians. In addition, it is an underdiagnosed and undertreated disorder. It is well known within the medical community of neurologists, and especially among headache specialists, that there is a need to disseminate knowledge about prophylactic treatment for migraine. For this purpose, together with the need for drug updates and to expand knowledge of the disease itself (frequency, intensity, duration, impact and perhaps the progression of migraine), this Consensus was developed, following a full online methodology, by 12 groups who reviewed and wrote about the pharmacological categories of the drugs used and, at the end of the process, met to read and establish conclusions for this document. The drug classes studied were: anticonvulsants, tricyclic antidepressants, monoclonal anti-calcitonin gene-related peptide (anti-CGRP) antibodies, beta-blockers, antihypertensives, calcium channel inhibitors, other antidepressants (selective serotonin reuptake inhibitors, SSRIs, and dual-action antidepressants), other drugs, and polytherapy. Hormonal treatment and anti-inflammatories and triptans in minimum prophylaxis schemes (miniprophylaxis) will be covered in a specific chapter. The drug classes studied for part I of the Consensus were: anticonvulsants, tricyclic antidepressants, monoclonal anti-CGRP antibodies, and beta-blockers.

Resumo A Sociedade Brasileira de Cefaleia (SBCe) nomeou um Comitê de Autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da enxaqueca episódica com base em artigos da literatura mundial e da experiência pessoal. A enxaqueca é um distúrbio subdiagnosticado e subtratado que acomete um bilhão de pessoas no mundo e mais de 30 milhões de brasileiros. É conhecido na comunidade médica de neurologistas e, sobretudo, dos especialistas em cefaleia, a necessidade de se divulgar o conhecimento sobre o tratamento profilático da enxaqueca. Com esta finalidade, aliada às necessidades de atualizações de drogas e de se aumentar o conhecimento sobre a doença em si (frequência, intensidade, duração, impacto e talvez a progressão da enxaqueca), foi elaborado este Consenso, com metodologia totalmente on-line, por 12 grupos que revisaram e escreveram sobre as categorias farmacológicas das drogas e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de drogas estudadas para este Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais do antipeptídeo relacionado ao gene da calcitonina (peptídeo relacionado ao gene da calcitonina — anti-CGRP), betabloqueadores, anti-hipertensivos, inibidores dos canais de cálcio, outros antidepressivos (inibidores seletivos de recaptação de serotonina, ISRSs, e antidepressivos de ação dual), outras drogas, e politerapia. O tratamento hormonal, bem como anti-inflamatórios e triptanas em esquema de profilaxia mínima (miniprofilaxia), será abordado em um capítulo próprio. As classes de drogas estudadas na parte I do Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais anti-CGRP, e betabloqueadores.

https://doi.org/10.1055/s-0042-1756441

Are rating of perceived exertion and heart rate methods useful to monitor the internal training load in functional training?
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Luz, Suelen Rodrigues da

; Silva, Bruno Ferrari

; Moreira, Alexandre

; Machado, Fabiana Andrade

; Peres, Sidney Barnabé

; Moraes, Solange Marta Franzói de

Motriz: Revista de Educação Física

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2022, Volume 28 elocation e102200018221

Abstract: En | Text: En | PDF: En

Abstract Aim: The study aimed to quantify and characterize the Training Load (TL) in a Functional Training (FT) model using Heart Rate (HR) and Session Rating of Perceived Exertion (sRPE) methods, and to verify whether these methods could be valid to monitor the TL during a FT program. Methods: The study design consisted of two phases: phase 1 - composed of a single training session of FT (FTSESSION), in which HR, sRPE, and pre- and post-exercise lactate [La] levels were assessed; phase 2 - composed of a FT program (FTPROGRAM) with eight weeks of duration and two sessions per week. The HR and SRPE were utilized to monitor all training sessions, and the results between sessions 1 vs. 8, 8 vs. 9, and 9 vs. 16 were compared. Results: On phase 1, HR distribution demonstrated that the participants spent about 75% of the total training time above 80% HRmax. Post-exercise [La] values were significantly higher (p < 0.05) than pre-exercise. The mean sRPE score was 8.5 ± 1.2. In phase 2, HR distribution was different between sessions 1-8 and 8-9 (p < 0.05). A strong correlation (r = 0.790) between the internal training load (ITL) and Training impulse (TRIMP) was observed. Conclusion: Our data demonstrated that the FTSESSION can be characterized as a high-intensity exercise, based on the pattern of HR responses and sRPE, and was reinforced by the [Lapeak]. Also, the TL monitoring methods (sRPE and TRIMP) proved to be valid for monitoring FT programs.

https://doi.org/10.1590/s1980-657420220018221

Primary and secondary modeling of Brochothrix thermosphacta growth under different temperature and ph values
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GONÇALVES, Leticia Dias dos Anjos

; PICCOLI, Roberta Hilsdorf

; PERES, Alexandre de Paula

; SAÚDE, André Vital

Food Science and Technology

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dec 2018, Volume 38 Pages 37 - 43

Abstract: En | Text: En | PDF: En

Abstract Bochothrix thermosphacta is an optional aerobic psychrotrophic related to the meat deterioration and consequently loss of a refrigerated cargo contaminated. Predictive microbiology can be used as a quality assurance tool, since it allows the prediction of microbial response based in pass observations. This work aimed model the growth of B. thermosphacta under variation of pH and temperature. For this purpose, the experimental growth data were fitted to the primary models of Baranyi and Roberts and the modified Gompertz model and the data for the maximum rate of growth (μmax) were adjusted to Ratkowsky extended secondary model. The results showed us that the influence of temperature on growth parameters was more evident than pH. Since, by fixing the temperature the change of pH little altered the μmax. However, as the temperature rises the elevation at the μmax is considerable, for example the comparison of predicted values for μmax, when the temperature exceeds 4 °C to 12 °C, it is clear that these rates are more than double. Finally, it is emphasized that all tested models feature good fit to the experimental data, which makes them validated for prediction growth of B. thermosphacta in the same conditions tested experimentally.

https://doi.org/10.1590/fst.13317 904 downloads

Predictive modeling of Pseudomonas fluorescens growth under different temperature and pH values
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Gonçalves, Letícia Dias dos Anjos

; Piccoli, Roberta Hilsdorf

; Peres, Alexandre de Paula

; Saúde, André Vital

Brazilian Journal of Microbiology

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jun 2017, Volume 48 N. 2 Pages 352 - 358

Abstract: En | Text: En | PDF: En

Abstract Meat is one of the most perishable foods owing to its nutrient availability, high water activity, and pH around 5.6. These properties are highly conducive for microbial growth. Fresh meat, when exposed to oxygen, is subjected to the action of aerobic psychrotrophic, proteolytic, and lipolytic spoilage microorganisms, such as Pseudomonas spp. The spoilage results in the appearance of slime and off-flavor in food. In order to predict the growth of Pseudomonas fluorescens in fresh meat at different pH values, stored under refrigeration, and temperature abuse, microbial mathematical modeling was applied. The primary Baranyi and Roberts and the modified Gompertz models were fitted to the experimental data to obtain the growth parameters. The Ratkowsky extended model was used to determine the effect of pH and temperature on the growth parameter µmax. The program DMFit 3.0 was used for model adjustment and fitting. The experimental data showed good fit for both the models tested, and the primary and secondary models based on the Baranyi and Roberts models showed better validation. Thus, these models can be applied to predict the growth of P. fluorescens under the conditions tested.

https://doi.org/10.1016/j.bjm.2016.12.006 2031 downloads

Análise de Modos e Efeitos de Falha na avaliação dos impactos ambientais provenientes do abate animal
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Rabelo, Mariane Helena Sances

; Silva, Eric Keven

; Peres, Alexandre de Paula

Engenharia Sanitaria e Ambiental

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mar 2014, Volume 19 N. 1 Pages 79 - 86

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A Análise de Modos e Efeitos de Falha (AMEF) é um método de análise de produto ou processo para detectar e eliminar problemas potenciais de forma sistemática e completa. Os abatedouros levam a significativos impactos sobre o meio ambiente, sendo que o maior problema nesses processos é a falta de equipamentos modernos para promover a remoção de gases fétidos e efluentes tóxicos. O objetivo deste trabalho foi elaborar os formulários de aplicação do FMEA em um frigorífico de médio porte da região de Poços de Caldas (MG), o qual realiza abates de bovinos e suínos, cujo intuito foi diagnosticar os potenciais riscos gerados pelo frigorífico, e aos controles ambientais exercidos em relação à linha de abate e graxaria. Observou-se que a indústria frigorífica representa um grande potencial poluidor sobre os efluentes naturais, pois o sangue resultante do abate é um agente de grande impacto sobre o ecossistema hídrico.

The Failure Mode and Effect Analysis (FMEA) is a method of product or process analysis to detect and eliminate potential problems in a systematic and complete way. The abattoirs lead to significant impacts on the environment, which the major problem in those processes is the lack of modern equipment to promote the removal of malodorous gases and toxic effluents. The aim of this study was to elaborate the FMEA application forms in a medium-sized abattoir in the region of Poços de Caldas (MG), which performs the cattle and pig slaughter, with the purpose of diagnosing its potential risks caused, and the environmental controls exercised in relation to the slaughter line and rendering plant. It was observed that the meat industry represents a great potential pollution on the natural effluents, because the resulting blood of the slaughter is an agent of great impact on the water ecosystem.

https://doi.org/10.1590/S1413-41522014000100009 15500 downloads

Freund's adjuvant-induced inflammation: clinical findings and its effect on hepcidin mRNA expression in horses
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Oliveira-Filho, José P.

; Badial, Peres R.

; Cunha, Paulo Henrique J.

; Bordon, Ana Paula

; Araujo Jr, João P.

; Divers, Thomas J.

; Winand, Nena J.

; Borges, Alexandre S.

Pesquisa Veterinária Brasileira

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jan 2014, Volume 34 N. 1 Pages 51 - 56

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A hipoferremia observada durante os processos inflamatórios sistêmicos é mediada pela hepcidina. O aumento da expressão da hepcidina é particularmente importante durante a inflamação aguda, por restringir a disponibilidade de ferro necessária para o crescimento de microrganismos patogênicos antes que a imunidade adaptativa ocorra. O objetivo deste estudo foi avaliar os achados clínicos e a expressão hepática do RNA mensageiro (RNAm) da hepcidina em cavalos após a indução da inflamação com Adjuvante completo de Freund (FCA). A expressão hepática do RNAm da hepcidina foi determinada em cavalos sadios após duas administrações intramusculares de FCA às 0 h (M0) e 12 h (M12). As concentrações plasmáticas de ferro e fibrinogênio foram mensuradas em múltiplos momentos entre 0 h e 240 h (M240) após a primeira administração de FCA (PI). A expressão do RNAm da hepcidina foi determinada por RT-qPCR usando amostras de biopsias hepáticas colhidas as 0 h (controle), 6 h (M6) e 18 h (M18) PI. A concentração plasmática média de fibrinogênio foi estatisticamente diferente do M0 entre 120 h e 216 h PI. A concentração plasmática média de ferro foi significantemente menor que o controle entre 16 h e 72 h PI, alcançou o nível mais baixo às 30 h PI (33% do valor inicial) e retornou aos valores de referência entre 96 h PI e até o final do experimento. A expressão do RNAm da hepcidina aumentou no M6 e permaneceu alta no M18. A concentração plasmática de ferro foi um indicador precoce da inflamação quando comparada com o fibrinogênio e pode ser útil na detecção precoce da inflamação em cavalos. A administração do FCA causou um rápido início da hipoferremia, e isto foi resultante do aumento da expressão hepática da hepcidina. Estes resultados enfatizam a importância da hepcidina e do metabolismo do ferro durante a inflamação em cavalos.

Hypoferremia observed during systemic inflammatory disorders is regulated by hepcidin. Hepcidin up-regulation is particularly important during acute inflammation, as it restricts the availability of iron, which is necessary for pathogenic microorganism growth before adaptive immunity occurs. The aim of this study was to evaluate the clinical findings and hepatic hepcidin mRNA expression in horses using a Freund's complete adjuvant (FCA) model of inflammation. The expression of hepcidin mRNA in the liver was determined in healthy horses following two intramuscular injections of FCA at 0 h and 12 h. Plasma iron and fibrinogen concentrations were measured at multiple time points between 0 h and 240 h post-FCA injection (PI). Hepcidin mRNA expression was determined by RT-qPCR using liver biopsy samples performed at 0 h (control), 6 h and 18 h PI. The mean plasma fibrinogen level was significantly different from the control values only between 120 and 216 h PI. The mean plasma iron level was significantly lower than the control between 16 and 72 h PI, reaching the lowest levels at 30 h PI (33 % of the initial value), and returned to the reference value from 96 h PI to the end of the experiment. Hepcidin mRNA expression increased at 6 h PI and remained high at 18 h PI. The iron plasma concentration was an earlier indicator of inflammatory processes in horses when compared with fibrinogen and might be useful for the early detection of inflammation in the horse. FCA administration caused the rapid onset of hypoferremia, and this effect was likely the result of up-regulated hepatic hepcidin gene expression. This study emphasizes the importance of hepcidin and iron metabolism during inflammation in horses.

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Avaliação integrada do impacto do uso de agrotóxicos sobre a saúde humana em uma comunidade agrícola de Nova Friburgo, RJ
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Moreira, Josino C.

; Jacob, Silvana C.

; Peres, Frederico

; Lima, Jaime S.

; Meyer, Armando

; Oliveira-Silva, Jefferson J.

; Sarcinelli, Paula N.

; Batista, Darcilio F.

; Egler, Mariana

; Faria, Mauro V. Castro

; Araújo, Alberto José de

; Kubota, Alexandre H.

; Soares, Mônica de O.

; Alves, Sergio R.

; Moura, Cláudia M.

; Curi, Rosane

Ciência & Saúde Coletiva

Journal Metrics
- Sobre o periódico
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2002, Volume 7 N. 2 Pages 299 - 311

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O impacto do uso de agrotóxicos sobre a saúde humana é um problema que tem merecido atenção da comunidade científica em todo o mundo, sobretudo nos países em desenvolvimento. O consumo de agrotóxicos na região sudeste do Brasil está estimado em 12kg de agrotóxico/trabalhador/ano. Em algumas áreas agrícolas do Estado do Rio de Janeiro, como na região da Microbacia do Córrego de São Lourenço, Nova Friburgo, o consumo de agrotóxico foi estimado em 56kg de agrotóxico/trabalhador/ano. Elevados níveis de contaminação humana e ambiental foram encontrados nesta região, como decorrência do uso extensivo destes agentes químicos. A avaliação do impacto sobre a saúde humana implica o conhecimento e a visualização da importância/magnitude relativa de cada uma das vias de contaminação. Inúmeros fatores, que, em geral, encontram-se inter-relacionados, contribuem para a situação encontrada na Microbacia do Córrego de São Lourenço e a forma mais adequada de se avaliar toda a dimensão deste problema é o uso de uma abordagem integrada.

Environmental and human difficulties caused by pesticides used in agriculture are important health issues worldwide, specially in the developing countries. Pesticide consumption in Southeast Brazil is estimated in 12kg/worker/year. In the São Lourenço Valley, Rio de Janeiro State, pesticide consumption is estimated at some 56kg/worker/year. High levels of human and environmental contamination caused by these products were found in the area. Many factors were shown as determinants of this situation, such as: pesticides with different formulations used with insufficient or even non-existent supervision or technical advice; intensive marketing activities place the responsibility for correct use and disposal of these chemicals on farm workers with low education levels typical of rural areas in Brazil, resulting in widespread human and environmental contamination. The evaluation of those loosely inter-related factors help shape the current situation in the São Lourenço Valley, indicating that the only way to really understand and assess the problem as a whole is through an integrative (transdisciplinary) approach.

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11.

Avaliação integrada do impacto do uso de agrotóxicos sobre a saúde humana em uma comunidade agrícola de Nova Friburgo, RJ
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Metrics
- SciELO Analytics

Moreira, Josino C.

; Jacob, Silvana C.

; Peres, Frederico

; Lima, Jaime S.

; Meyer, Armando

; Oliveira-Silva, Jefferson J.

; Sarcinelli, Paula N.

; Batista, Darcilio F.

; Egler, Mariana

; Faria, Mauro V. Castro

; Araújo, Alberto José de

; Kubota, Alexandre H.

; Soares, Mônica de O.

; Alves, Sergio R.

; Moura, Cláudia M.

; Curi, Rosane

Ciência & Saúde Coletiva

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2002, Volume 7 N. 2 Pages 299 - 311

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

24445 downloads

12.

Análise bioquímica das metaloproteases da matriz extracelular durante atrofia experimental das glândulas salivares submandibulares em ratos
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SOUZA, Ana Paula de

; TREVILATTO, Paula Cristina

; ZAIA, Alexandre Augusto

; LINE, Sérgio Roberto Peres

Revista de Odontologia da Universidade de São Paulo

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apr 1999, Volume 13 N. 2 Pages 135 - 139

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O presente estudo teve por objetivo analisar a expressão das metaloproteases da matriz extracelular durante a atrofia experimental das glândulas submandibulares em ratos, causada pela obstrução do ducto excretor principal. Os zimogramas realizados com extratos das porções internas e externas das glândulas salivares normais e ligadas mostraram que as principais enzimas gelatinolíticas possuíam pesos moleculares variando entre 72 kDa e 65 kDa. A atividade dessas enzimas aumentou progressivamente até o período entre 5 e 10 dias após a ligação, decrescendo nos períodos subseqüentes. Foram também detectadas bandas migrando entre 92 kDa e 72 kDa, sendo essas enzimas detectadas em quantidades significativas apenas na região da cápsula da glândula, no período de 2 dias. A confirmação de que as enzimas detectadas eram metaloproteases foi feita pelo uso de inibidores específicos. Os resultados sugerem que as metaloproteases da matriz têm um papel importante na remodelação da matriz extracelular durante a atrofia experimental da glândula submandibular.

The purpose of the present study was to analyze the expression of the major metalloproteases in normal and ligated glands. The major metalloproteases detected had a molecular weight ranging from 72 to 65 kDa. The gelatinolytic activity increased progressively reaching a peak between 5 and 10 days after ligation. Bands with molecular weight ranging from 92-80 kDa were also detected in the capsule of the gland. The 92-80 kDa enzymes were only detected 2 days after ligation. The activity of these enzymes was supressed by specific inhibitors. Our results show that matrix metalloproteases play an active role in the extensive remodeling of the connective tissue that occurs during the atrophy of the submandibular gland.

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