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Revisores 2023
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Molas de la Quintana, Adriana Beatriz
; Jimenez Genchi, Alejandro
; Carrizales, Alexia
; Gotti, Amanda
; Martinez Ortiz, Ana
; Rocío Martínez Yacelga, Ana del
; Camilo Ciantelli, Ana Paula
; Jimenez Figueroa, Andres
; Neumann, Angélica Paula
; Parodi Svartman, Bernardo
; Vazquez Rodriguez, Carolina
; Da Silva, Cecilia
; Baroni, Cecilia
; Lanza Perez, Cintia Beatriz
; Mola, Débora
; Alarcón Rubio, David
; Perales Mejia, Felipe de Jesús
; Sarachu, Gerardo
; Gelpi, Gonzalo
; Sosa, Gustavo
; Viana Batista, Helder
; Moizéis, Heloísa Bárbara Cunha
; Carrasco, Jimena
; Ungaretti, Joaquín
; Moreira, Karen
; Tomatis, Karina
; Oros, Laura Beatriz
; Mazaro, Lisabelle Manente
; Chiavone, Luciana
; Perilla Toro, Lyria Esperanza
; Campagnoli, Mabel Alicia
; Ruiz Barbot, Mabela
; Brenlla, María Elena
; Folle Chavannes, María Ana
; Freytes Frey, Marcela
; Rossal, Marcelo
; Ortiz, Maria Victoria
; Nabergoi, Mariela
; Montenegro, Marisela
; Lladó, Mónica
; Freitas De León, Paribanú
; Solís García, Patricia
; Ruiz Santos, Paul
; Fiorati, Regina Célia
; Martins, Rita de Cássia Andrade
; Dominguez-Lara, Sergio Alexis
; Herranz, Silvana Melisa
; Yoma, Solana María
; Gondim, Sonia Maria Guedes
; Rostagnol, Susana
; Wittke, Tommy
; Ballesteros, Virginia
; Tamayo, William
.
2.
Fluoride-modified implant surfaces improves osseointegration in the tibias of rats with induced diabetes
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Oliveira, Guilherme José Pimentel Lopes de
; Fontanari, Lucas Amaral
; Souza, João Antônio Chaves de
; Spin-Neto, Rubens
; Elias, Carlos Nelson
; Marcantonio Junior, Elcio
; Orrico, Silvana Regina Perez
.
Abstract This study evaluated the influence of a fluoride-modified titanium surface on osseointegration in rats with induced diabetes. One hundred and eighty rats were randomly allocated into 3 groups with 60 animals each: Control group (C): Animals without diabetes; Diabetes Group (D): Animals with uncontrolled induced diabetes; Controlled Diabetes Group (CD): Animals with diabetes induced controlled by the insulin administration. Diabetes was induced by streptozotocin injection. Each animal received 2 implants in the proximal tibial metaphysis, one with the machined surface (M) and the other one with a fluoride-modified titanium surface (F), after 4 weeks of induction of diabetes. The animals were submitted to euthanasia 2, 4, and 6 weeks after the implant placement (n = 20 animals/group). The osseointegration was evaluated by the implant removal torque test and the histometric analysis of the non-decalcified histological sections: 1) Contact bone/implant (%BIC); 2) Bone tissue area between implant threads (%BBT). Implants with F surface showed a higher removal torque than implants with surface M in all groups. There was no difference in %BIC between the groups regardless of the surface used. The F surface showed a tendency to present higher %BBT values for the 3 evaluation periods in the D group. The fluoride-modified implant surface has no impact on the %BIC and %BBT. However, the fluoride-modified implant surface increases the locking of the implants with the bone. The hyperglycemia was associated with lower removal torque values despite the surfaces of the implant used.
Resumo Este estudo avaliou a influência de uma superfície de titânio modificada com flúor na osseointegração em ratos com diabetes induzida. Cento e oitenta ratos foram distribuídos aleatoriamente em 3 grupos com 60 animais cada: Grupo controle (C): Animais sem diabetes; Grupo Diabetes (D): Animais com diabetes induzida descompensada; Grupo Diabetes Controlado (CD): Animais com diabetes induzido controlado pela administração de insulina. O diabetes foi induzido por injeção de estreptozotocina. Cada animal recebeu 2 implantes na metáfise proximal da tíbia, um com superfície usinada (M) e outro com superfície de titânio modificado com flúor (F), após 4 semanas de indução do diabetes. Os animais foram submetidos à eutanásia 2, 4 e 6 semanas após a colocação do implante (n = 20 animais/grupo). A osseointegração foi avaliada pelo teste de torque de remoção do implante e pela análise histométrica dos cortes histológicos não descalcificados: 1) Contato osso-implante (%BIC); 2) Área de tecido ósseo entre as roscas do implante (%BBT). Os implantes com superfície F apresentaram maior torque de remoção do que os implantes com superfície M em todos os grupos. Não houve diferença no %BIC entre os grupos independente da superfície utilizada. A superfície F mostrou tendência a apresentar maiores valores de %BBT para os 3 períodos de avaliação no grupo D. As superfícies de implantes modificadas com flúor não influenciaram nos dados de %BIC e %BBT. Entretanto, essas superfícies aumentaram o travamento dos implantes no tecido ósseo. A hiperglicemia foi associada a menores torques de remoção dos implantes independentemente do tipo de superfície de implante utilizada.
3.
Beyond Atherothrombotic Disease in Acute Coronary Syndrome
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Mora, Mayra Alejandra
; Molano-Perez, Manuela
; Becerra-Gonzalez, Cristian Orlando
; Buitrago-Toro, Kenny
; Jimenez-Salazar, Silvana
; Ortiz, Carlos
.
International Journal of Cardiovascular Sciences
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Abstract Half of the global population over 20 years of age will be affected by cardiovascular disease. Cardiovascular events in young people is challenging. Spontaneous coronary artery dissection is a non-traumatic and non-iatrogenic separation of the coronary arterial wall and is an uncommon and underdiagnosed cause of acute myocardial infarction predominately found in young women. Medical management has been more widely accepted, with percutaneous and surgery treatment reserved for precise indications. Optimal control of individual risk factors is essential in order to avoid recurrences.
4.
Rendimiento estudiantil en tiempo de pandemia: percepciones sobre aspectos con mayor impacto
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Revista Iberoamericana de Tecnología en Educación y Educación en Tecnología
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This article analyzes the results of a survey of undergraduate students regarding their transit through the first semester in the context of a health emergency. It is observed that students associate their performance in the first place with aspects related to their participation and difficulties in carrying out that participation. Regarding the aspects of the teaching design, the time available for assessments, the variety of the proposed activities, the teacher-student interaction, the explanation of objectives, and coherent planning stand out. Likewise, the need for interaction with the teaching teams is observed, showing dissatisfaction when that interaction is not fluid, there is no response to the messages or feedback to the tasks.
En este artÃculo se analizan los resultados de una encuesta realizada a estudiantes de grado respecto de su tránsito por el primer semestre en contexto de emergencia sanitaria en la Universidad de la República en Uruguay. Se observa que los estudiantes asocian su rendimiento en primer lugar a aspectos vinculados a su participación y dificultades para llevar a cabo esa participación. Respecto de los aspectos del diseño de los procesos de enseñanza por parte de los equipos docentes, se destacan el tiempo disponible para realizar las evaluaciones, la diversidad de actividades propuestas, los espacios de interacción docente-alumnado, la explicitación de objetivos y la coherencia de la planificación. Se observa, asimismo, la necesidad de interacción con los equipos docentes, presentando insatisfacción cuando esa interacción no es fluida, no hay respuesta a los mensajes o retroalimentación a las tareas.
233 downloads
5.
Transmission cluster of COVID-19 cases from Uruguay: emergence and spreading of a novel SARS-CoV-2 ORF6 deletion
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Panzera, Yanina
; Ramos, Natalia
; Calleros, Lucía
; Marandino, Ana
; Tomás, Gonzalo
; Techera, Claudia
; Grecco, Sofía
; Frabasile, Sandra
; Fuques, Eddie
; Coppola, Leticia
; Goñi, Natalia
; Ramas, Viviana
; Sorhouet, Cecilia
; Bormida, Victoria
; Burgueño, Analía
; Brasesco, María
; Garland, Maria Rosa
; Molinari, Sylvia
; Perez, Maria Teresa
; Somma, Rosina
; Somma, Silvana
; Morel, Maria Noelia
; Mogdasy, Cristina
; Chiparelli, Héctor
; Arbiza, Juan
; Delfraro, Adriana
; Pérez, Ruben
.
BACKGROUND Evolutionary changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include indels in non-structural, structural, and accessory open reading frames (ORFs) or genes. OBJECTIVES We track indels in accessory ORFs to infer evolutionary gene patterns and epidemiological links between outbreaks. METHODS Genomes from Coronavirus disease 2019 (COVID-19) case-patients were Illumina sequenced using ARTIC_V3. The assembled genomes were analysed to detect substitutions and indels. FINDINGS We reported the emergence and spread of a unique 4-nucleotide deletion in the accessory ORF6, an interesting gene with immune modulation activity. The deletion in ORF6 removes one repeat unit of a two 4-nucleotide repeat, which shows that directly repeated sequences in the SARS-CoV-2 genome are associated with indels, even outside the context of extended repeat regions. The 4-nucleotide deletion produces a frameshifting change that results in a protein with two inserted amino acids, increasing the coding information of this accessory ORF. Epidemiological and genomic data indicate that the deletion variant has a single common ancestor and was initially detected in a health care outbreak and later in other COVID-19 cases, establishing a transmission cluster in the Uruguayan population. MAIN CONCLUSIONS Our findings provide evidence for the origin and spread of deletion variants and emphasise indels’ importance in epidemiological studies, including differentiating consecutive outbreaks occurring in the same health facility.
6.
Application of chlorine dioxide (ClO2) and marine yeasts to control postharvest anthracnose disease in mango (Mangifera indica L.)
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Reyes-Perez, Juan J.
; Vero, Silvana
; Diaz-Rivera, Ernesto
; Lara-Capistran, Liliana
; Noa-Carrazana, Juan C.
; Hernandez-Montiel, Luis G.
.
Abstract Postharvest diseases in fruits cause serious losses of fresh produce worldwide. The application of synthetic fungicides for the control of postharvest diseases such as anthracnose in mangoes can cause adverse effects on the environment and on human and animal health and has generated phytopathogen resistance. Biological control with the application of marine yeasts and chlorine dioxide (ClO2) to reduce the use of synthetic fungicides can be an alternative to prevent anthracnose in Ataulfo mango fruits. The results showed that different doses of ClO2 inhibited the mycelium growth and spore germination of Colletotrichum gloeosporioides in vitro. When ClO2 and the marine yeasts Debaryomyces hansenii and Rhodotorula minuta were applied to mango fruits, no signs of anthracnose disease incidence and lesion diameter were observed (LSD, p<0.05). Therefore, the application of ClO2 plus antagonist yeasts provides excellent control of anthracnose disease in Ataulfo mango fruits.
Resumen Las enfermedades poscosecha de las frutas causan pérdidas económicas en todo el mundo. La aplicación de fungicidas sintéticos para el control de las enfermedades en poscosecha como la antracnosis en mango puede causar efectos adversos al medio ambiente, la salud humana y animal, además de generar resistencia en los fitopatógenos. El control biológico a través de levaduras marinas y la aplicación del dióxido de cloro (ClO2) pueden ser una alternativa para el control de la antracnosis en frutos de mango cv. Ataulfo y, en la reducción de la aplicación de fungicidas sintéticos. Los resultados indican que diferentes dosis de ClO2 inhibieron in vitro el crecimiento del micelio y la germinación de esporas de C. gloeosporioides. Cuando se aplicó ClO2 y las levaduras marinas Debaryomyces hansenii y Rhodotorula minuta sobre frutos de mango, no se observaron signos de incidencia y lesión de antracnosis (LSD, p<0.05). Por lo tanto, la aplicación de levaduras antagonistas más ClO2 proporciona un control eficiente sobre la antracnosis en frutos de mango cv. Ataulfo.
https://doi.org/10.7764/rcia.v46i3.2005
2577 downloads
7.
O estudo do movimento browniano com material de baixo custo
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O estudo do movimento browniano é visto em disciplinas de física moderna de cursos de graduação em física, seguindo uma abordagem teórica ou de laboratório, neste caso geralmente envolvendo equipamentos de razoável sofisticação. Neste trabalho é descrita uma proposta de implementação do experimento no ensino médio, pensada e desenvolvida por estudantes do último semestre do curso noturno de licenciatura em Física da Universidade Federal do Pará, como parte das atividades de uma disciplina de Física Estatística. A facilidade da montagem do experimento, aliada ao uso de tecnologias computacionais para a análise dos resultados, faz com que a técnica possa ser facilmente implementada no ensino médio, possibilitando ao estudante discutir aspectos históricos do desenvolvimento dos modelos atômicos, bem como realizar a medição experimental do número de Avogrado, visto usualmente em Química, de forma mecanizada.
The study of Brownian motion is seen in modern physics disciplines of undergraduate courses in physics, following a theoretical or laboratory approach, in this case usually involving reasonably sophisticated equipment. This work describes a proposal for the implementation of the experiment in high school, designed and developed by students of the last semester of the night course of licentiate in Physics of the Federal University of Para, as part of the activities of a discipline of Statistical Physics. The ease of assembly of the experiment, combined with the use of computational technologies to analyze the results, makes the technique easily implemented in high school, enabling the student to discuss historical aspects of the development of atomic models, as well as to perform the experimental measurement of the number of Avogrado, usually seen in Chemistry, in a mechanized way.
https://doi.org/10.1590/1806-9126-rbef-2016-0297
4076 downloads
8.
Atividades investigativas e o desenvolvimento de habilidades e competências: um relato de experiência no curso de Física da Universidade Federal do Pará
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Fraiha, Simone
; Paschoal Jr, Waldomiro
; Perez, Silvana
; Tabosa, Clara E.S.
; Silva Alves, João Paulo da
; Silva, Charles Rocha
.
Resumo Neste trabalho apresentamos um relato de experiência de uma disciplina piloto implementada em uma turma de ingressantes no curso de graduação em Física (licenciatura e bacharelado) da Universidade Federal do Pará, durante o primeiro semestre de 2017. Tendo como base o uso de atividades investigativas no ensino, durante o semestre de trabalho, os estudantes foram divididos em equipes e a cada uma delas foi proposto um problema de Ciências em aberto, para o qual os alunos tiveram que emitir hipóteses, planejar um aparato experimental, coletar dados e interpretar os resultados de forma a responder o problema proposto. Na análise da proposta didática, apresentamos os principais aspectos pontuados pelos professores que aplicaram a metodologia. Em se tratando diretamente dos estudantes, pôde-se perceber um maior engajamento nas atividades propostas pelo professor e um aumento da autoeficácia. Indiretamente, observou-se um maior respeito à liberdade criativa e ao ritmo de aprendizado de cada aluno no que tange ao aprendizado dos conceitos de Física relevantes, bem como ao desenvolvimento de competências relacionadas à capacidade de resolver problemas de pesquisa e do seu cotidiano. Entre outros aspectos pontuados pelos professores destacam-se uma sensibilidade da metodologia à turma, bem como à escolha dos problemas propostos.
Abstract In this work we present an experience report of a pilot discipline implemented in a group of students enrolled in the undergraduate course in Physics (licentiate and bachelor's degree) at the Federal University of Pará, during the first semester of 2017. Based on the use of investigative activities, during the semester, the students were divided into teams and for each them it was proposed an open-ended science problem, for which students had to make hypotheses, plan an experimental apparatus, collect data and interpret the results with the goal of responding the proposed problem. In the analysis of the didactic proposal, we present the main aspects punctuated by the teachers who applied the methodology. When dealing directly with the students, there was a greater involvement in the activities proposed by the teacher and an increase in self-efficacy. Indirectly, there was a greater respect for the creative freedom and learning pace of each student in learning the relevant physics concepts, as well as the development of competences related to the ability to solve research problems and in their daily life. Among other points scored by teachers, a sensitivity of the methodology to the class is highlighted, as well as to the choice of proposed problems.
https://doi.org/10.1590/1806-9126-rbef-2018-0052
2996 downloads
9.
Effectiveness and safety of first-generation protease inhibitors in real-world patients with hepatitis C virus genotype 1 infection in Brazil: a multicenter study
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Callefi, Luciana Azevedo
; Villela-Nogueira, Cristiane Alves
; de Barros Tenore, Simone
; Carnaúba-Júnior, Dimas
; Coelho, Henrique Sérgio Moraes
; Pinto, Paulo de Tarso A.
; Nabuco, Letícia Cancella
; Pessoa, Mário Guimarães
; Ferraz, Maria Lucia Cardoso Gomes
; Ferreira, Paulo Roberto Abrão
; de Lourdes Candolo Martinelli, Ana
; Chachá, Silvana Gama Florencio
; de Souza Paiva Ferreira, Adalgisa
; de Macedo Bisio, Alessandra Porto
; Brandão-Mello, Carlos Eduardo
; Álvares-Da-Silva, Mário Reis
; Reuter, Tânia
; Ivantes, Claudia Alexandra Pontes
; de Mello Perez, Renata
; Mendes-Correa, Maria Cássia Jacintho
.
OBJECTIVE: To evaluate the effectiveness and safety of first-generation protease inhibitors for the treatment of genotype 1 hepatitis C virus-infected patients at Brazilian reference centers. METHODS: This multicenter cross-sectional study included hepatitis C virus genotype 1 monoinfected patients treated with Peg-interferon, ribavirin, and either boceprevir (n=158) or telaprevir (n=557) between July 2013 and April 2014 at 15 reference centers in Brazil. Demographic, clinical, virological, and adverse events data were collected during treatment and follow-up. RESULTS: Of the 715 patients, 59% had cirrhosis and 67.1% were treatment-experienced. Based on intention-to-treat analysis, the overall sustained viral response was 56.6%, with similar effectiveness in both groups (51.9% for boceprevir and 58% for telaprevir, p=0.190). Serious adverse events occurred in 44.2% of patients, and six deaths (0.8%) were recorded. Cirrhotic patients had lower sustained viral response rates than non-cirrhotic patients (46.9% vs. 70.6%, p<0.001) and a higher incidence of serious adverse events (50.7% vs. 34.8%, p<0.001). Multivariate analysis revealed that sustained viral response was associated with the absence of cirrhosis, viral recurrence after previous treatment, pretreatment platelet count greater than 100,000/mm3, and achievement of a rapid viral response. Female gender, age>65 years, diagnosis of cirrhosis, and abnormal hemoglobin levels/platelet counts prior to treatment were associated with serious adverse events. CONCLUSION: Although serious adverse events rates were higher in this infected population, sustained viral response rates were similar to those reported for other patient cohorts.
https://doi.org/10.6061/clinics/2017(06)08
869 downloads
10.
Medindo a velocidade do som utilizando figuras de Lissajous
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Revista Brasileira de Ensino de Física
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Existem várias técnicas para obter a velocidade do som no ar à temperatura ambiente, desde as mais simples, que envolvem a razão entre distâncias percorridas e tempos até as mais sofisticadas, associadas a fenômenos oscilatórios. Neste trabalho propomos um aparato experimental de considerável baixo custo para medir esta velocidade que envolve figuras de Lissajous e tubos ressonantes. Os fenômenos físicos envolvidos no processo possibilitam ao estudante observar e se aprofundar no entendimento de vários conceitos de física ondulatória, bem como discutir o conceito de superposição de movimentos e pode ser desenvolvido por estudantes do ciclo avançado de cursos de Física e Engenharias.
There are several techniques to obtain the sound velocity in air, from the very simple ones, which use the relation between distances and time, until the more sophisticated ones, associated with oscillatory phenomena. In this work we propose an experimental aparathus which involves the Lissajous figures and ressonance tubes. The physical phenomena that appear in the process allow the student to observe and understand several ondulatory processes, as well as the superposition principle and can be applied to engenier and physics undergraduate students.
https://doi.org/10.1590/S1806-11173731909
2643 downloads
11.
Growing knowledge: an overview of Seed Plant diversity in Brazil
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Zappi, Daniela C.
; Filardi, Fabiana L. Ranzato
; Leitman, Paula
; Souza, Vinícius C.
; Walter, Bruno M.T.
; Pirani, José R.
; Morim, Marli P.
; Queiroz, Luciano P.
; Cavalcanti, Taciana B.
; Mansano, Vidal F.
; Forzza, Rafaela C.
; Abreu, Maria C.
; Acevedo-Rodríguez, Pedro
; Agra, Maria F.
; Almeida Jr., Eduardo B.
; Almeida, Gracineide S.S.
; Almeida, Rafael F.
; Alves, Flávio M.
; Alves, Marccus
; Alves-Araujo, Anderson
; Amaral, Maria C.E.
; Amorim, André M.
; Amorim, Bruno
; Andrade, Ivanilza M.
; Andreata, Regina H.P.
; Andrino, Caroline O.
; Anunciação, Elisete A.
; Aona, Lidyanne Y.S.
; Aranguren, Yani
; Aranha Filho, João L.M.
; Araújo, Andrea O.
; Araújo, Ariclenes A.M.
; Araújo, Diogo
; Arbo, María M.
; Assis, Leandro
; Assis, Marta C.
; Assunção, Vivian A.
; Athiê-Souza, Sarah M.
; Azevedo, Cecilia O.
; Baitello, João B.
; Barberena, Felipe F.V.A.
; Barbosa, Maria R.V.
; Barros, Fábio
; Barros, Lucas A.V.
; Barros, Michel J.F.
; Baumgratz, José F.A.
; Bernacci, Luis C.
; Berry, Paul E.
; Bigio, Narcísio C.
; Biral, Leonardo
; Bittrich, Volker
; Borges, Rafael A.X.
; Bortoluzzi, Roseli L.C.
; Bove, Cláudia P.
; Bovini, Massimo G.
; Braga, João M.A.
; Braz, Denise M.
; Bringel Jr., João B.A.
; Bruniera, Carla P.
; Buturi, Camila V.
; Cabral, Elza
; Cabral, Fernanda N.
; Caddah, Mayara K.
; Caires, Claudenir S.
; Calazans, Luana S.B.
; Calió, Maria F.
; Camargo, Rodrigo A.
; Campbell, Lisa
; Canto-Dorow, Thais S.
; Carauta, Jorge P.P.
; Cardiel, José M.
; Cardoso, Domingos B.O.S.
; Cardoso, Leandro J.T.
; Carneiro, Camila R.
; Carneiro, Cláudia E.
; Carneiro-Torres, Daniela S.
; Carrijo, Tatiana T.
; Caruzo, Maria B.R.
; Carvalho, Maria L.S.
; Carvalho-Silva, Micheline
; Castello, Ana C.D.
; Cavalheiro, Larissa
; Cervi, Armando C.
; Chacon, Roberta G.
; Chautems, Alain
; Chiavegatto, Berenice
; Chukr, Nádia S.
; Coelho, Alexa A.O.P.
; Coelho, Marcus A.N.
; Coelho, Rubens L.G.
; Cordeiro, Inês
; Cordula, Elizabeth
; Cornejo, Xavier
; Côrtes, Ana L.A.
; Costa, Andrea F.
; Costa, Fabiane N.
; Costa, Jorge A.S.
; Costa, Leila C.
; Costa-e-Silva, Maria B.
; Costa-Lima, James L.
; Cota, Maria R.C.
; Couto, Ricardo S.
; Daly, Douglas C.
; De Stefano, Rodrigo D.
; De Toni, Karen
; Dematteis, Massimiliano
; Dettke, Greta A.
; Di Maio, Fernando R.
; Dórea, Marcos C.
; Duarte, Marília C.
; Dutilh, Julie H.A.
; Dutra, Valquíria F.
; Echternacht, Lívia
; Eggers, Lilian
; Esteves, Gerleni
; Ezcurra, Cecilia
; Falcão Junior, Marcus J.A.
; Feres, Fabíola
; Fernandes, José M.
; Ferreira, D.M.C.
; Ferreira, Fabrício M.
; Ferreira, Gabriel E.
; Ferreira, Priscila P.A.
; Ferreira, Silvana C.
; Ferrucci, Maria S.
; Fiaschi, Pedro
; Filgueiras, Tarciso S.
; Firens, Marcela
; Flores, Andreia S.
; Forero, Enrique
; Forster, Wellington
; Fortuna-Perez, Ana P.
; Fortunato, Reneé H.
; Fraga, Cléudio N.
; França, Flávio
; Francener, Augusto
; Freitas, Joelcio
; Freitas, Maria F.
; Fritsch, Peter W.
; Furtado, Samyra G.
; Gaglioti, André L.
; Garcia, Flávia C.P.
; Germano Filho, Pedro
; Giacomin, Leandro
; Gil, André S.B.
; Giulietti, Ana M.
; A.P.Godoy, Silvana
; Goldenberg, Renato
; Gomes da Costa, Géssica A.
; Gomes, Mário
; Gomes-Klein, Vera L.
; Gonçalves, Eduardo Gomes
; Graham, Shirley
; Groppo, Milton
; Guedes, Juliana S.
; Guimarães, Leonardo R.S.
; Guimarães, Paulo J.F.
; Guimarães, Elsie F.
; Gutierrez, Raul
; Harley, Raymond
; Hassemer, Gustavo
; Hattori, Eric K.O.
; Hefler, Sonia M.
; Heiden, Gustavo
; Henderson, Andrew
; Hensold, Nancy
; Hiepko, Paul
; Holanda, Ana S.S.
; Iganci, João R.V.
; Imig, Daniela C.
; Indriunas, Alexandre
; Jacques, Eliane L.
; Jardim, Jomar G.
; Kamer, Hiltje M.
; Kameyama, Cíntia
; Kinoshita, Luiza S.
; Kirizawa, Mizué
; Klitgaard, Bente B.
; Koch, Ingrid
; Koschnitzke, Cristiana
; Krauss, Nathália P.
; Kriebel, Ricardo
; Kuntz, Juliana
; Larocca, João
; Leal, Eduardo S.
; Lewis, Gwilym P.
; Lima, Carla T.
; Lima, Haroldo C.
; Lima, Itamar B.
; Lima, Laíce F.G.
; Lima, Laura C.P.
; Lima, Leticia R.
; Lima, Luís F.P.
; Lima, Rita B.
; Lírio, Elton J.
; Liro, Renata M.
; Lleras, Eduardo
; Lobão, Adriana
; Loeuille, Benoit
; Lohmann, Lúcia G.
; Loiola, Maria I.B.
; Lombardi, Julio A.
; Longhi-Wagner, Hilda M.
; Lopes, Rosana C.
; Lorencini, Tiago S.
; Louzada, Rafael B.
; Lovo, Juliana
; Lozano, Eduardo D.
; Lucas, Eve
; Ludtke, Raquel
; Luz, Christian L.
; Maas, Paul
; Machado, Anderson F.P.
; Macias, Leila
; Maciel, Jefferson R.
; Magenta, Mara A.G.
; Mamede, Maria C.H.
; Manoel, Evelin A.
; Marchioretto, Maria S.
; Marques, Juliana S.
; Marquete, Nilda
; Marquete, Ronaldo
; Martinelli, Gustavo
; Martins da Silva, Regina C.V.
; Martins, Ângela B.
; Martins, Erika R.
; Martins, Márcio L.L.
; Martins, Milena V.
; Martins, Renata C.
; Matias, Ligia Q.
; Maya-L., Carlos A.
; Mayo, Simon
; Mazine, Fiorella
; Medeiros, Debora
; Medeiros, Erika S.
; Medeiros, Herison
; Medeiros, João D.
; Meireles, José E.
; Mello-Silva, Renato
; Melo, Aline
; Melo, André L.
; Melo, Efigênia
; Melo, José I.M.
; Menezes, Cristine G.
; Menini Neto, Luiz
; Mentz, Lilian A.
; Mezzonato, A.C.
; Michelangeli, Fabián A.
; Milward-de-Azevedo, Michaele A.
; Miotto, Silvia T.S.
; Miranda, Vitor F.O.
; Mondin, Cláudio A.
; Monge, Marcelo
; Monteiro, Daniele
; Monteiro, Raquel F.
; Moraes, Marta D.
; Moraes, Pedro L.R.
; Mori, Scott A.
; Mota, Aline C.
; Mota, Nara F.O.
; Moura, Tania M.
; Mulgura, Maria
; Nakajima, Jimi N.
; Nardy, Camila
; Nascimento Júnior, José E.
; Noblick, Larry
; Nunes, Teonildes S.
; O'Leary, Nataly
; Oliveira, Arline S.
; Oliveira, Caetano T.
; Oliveira, Juliana A.
; Oliveira, Luciana S.D.
; Oliveira, Maria L.A.A.
; Oliveira, Regina C.
; Oliveira, Renata S.
; Oliveira, Reyjane P.
; Paixão-Souza, Bruno
; Parra, Lara R.
; Pasini, Eduardo
; Pastore, José F.B.
; Pastore, Mayara
; Paula-Souza, Juliana
; Pederneiras, Leandro C.
; Peixoto, Ariane L.
; Pelissari, Gisela
; Pellegrini, Marco O.O.
; Pennington, Toby
; Perdiz, Ricardo O.
; Pereira, Anna C.M.
; Pereira, Maria S.
; Pereira, Rodrigo A.S.
; Pessoa, Clenia
; Pessoa, Edlley M.
; Pessoa, Maria C.R.
; Pinto, Luiz J.S.
; Pinto, Rafael B.
; Pontes, Tiago A.
; Prance, Ghillean T.
; Proença, Carolyn
; Profice, Sheila R.
; Pscheidt, Allan C.
; Queiroz, George A.
; Queiroz, Rubens T.
; Quinet, Alexandre
; Rainer, Heimo
; Ramos, Eliana
; Rando, Juliana G.
; Rapini, Alessandro
; Reginato, Marcelo
; Reis, Ilka P.
; Reis, Priscila A.
; Ribeiro, André R.O.
; Ribeiro, José E.L.S.
; Riina, Ricarda
; Ritter, Mara R.
; Rivadavia, Fernando
; Rocha, Antônio E.S.
; Rocha, Maria J.R.
; Rodrigues, Izabella M.C.
; Rodrigues, Karina F.
; Rodrigues, Rodrigo S.
; Rodrigues, Rodrigo S.
; Rodrigues, Vinícius T.
; Rodrigues, William
; Romaniuc Neto, Sérgio
; Romão, Gerson O.
; Romero, Rosana
; Roque, Nádia
; Rosa, Patrícia
; Rossi, Lúcia
; Sá, Cyl F.C.
; Saavedra, Mariana M.
; Saka, Mariana
; Sakuragui, Cássia M.
; Salas, Roberto M.
; Sales, Margareth F.
; Salimena, Fatima R.G.
; Sampaio, Daniela
; Sancho, Gisela
; Sano, Paulo T.
; Santos, Alessandra
; Santos, Élide P.
; Santos, Juliana S.
; Santos, Marianna R.
; Santos-Gonçalves, Ana P.
; Santos-Silva, Fernanda
; São-Mateus, Wallace
; Saraiva, Deisy P.
; Saridakis, Dennis P.
; Sartori, Ângela L.B.
; Scalon, Viviane R.
; Schneider, Ângelo
; Sebastiani, Renata
; Secco, Ricardo S.
; Senna, Luisa
; Senna-Valle, Luci
; Shirasuna, Regina T.
; Silva Filho, Pedro J.S.
; Silva, Anádria S.
; Silva, Christian
; Silva, Genilson A.R.
; Silva, Gisele O.
; Silva, Márcia C.R.
; Silva, Marcos J.
; Silva, Marcos J.
; Silva, Otávio L.M.
; Silva, Rafaela A.P.
; Silva, Saura R.
; Silva, Tania R.S.
; Silva-Gonçalves, Kelly C.
; Silva-Luz, Cíntia L.
; Simão-Bianchini, Rosângela
; Simões, André O.
; Simpson, Beryl
; Siniscalchi, Carolina M.
; Siqueira Filho, José A.
; Siqueira, Carlos E.
; Siqueira, Josafá C.
; Smith, Nathan P.
; Snak, Cristiane
; Soares Neto, Raimundo L.
; Soares, Kelen P.
; Soares, Marcos V.B.
; Soares, Maria L.
; Soares, Polyana N.
; Sobral, Marcos
; Sodré, Rodolfo C.
; Somner, Genise V.
; Sothers, Cynthia A.
; Sousa, Danilo J.L.
; Souza, Elnatan B.
; Souza, Élvia R.
; Souza, Marcelo
; Souza, Maria L.D.R.
; Souza-Buturi, Fátima O.
; Spina, Andréa P.
; Stapf, María N.S.
; Stefano, Marina V.
; Stehmann, João R.
; Steinmann, Victor
; Takeuchi, Cátia
; Taylor, Charlotte M.
; Taylor, Nigel P.
; Teles, Aristônio M.
; Temponi, Lívia G.
; Terra-Araujo, Mário H.
; Thode, Veronica
; Thomas, W.Wayt
; Tissot-Squalli, Mara L.
; Torke, Benjamin M.
; Torres, Roseli B.
; Tozzi, Ana M.G.A.
; Trad, Rafaela J.
; Trevisan, Rafael
; Trovó, Marcelo
; Valls, José F.M.
; Vaz, Angela M.S.F.
; Versieux, Leonardo
; Viana, Pedro L.
; Vianna Filho, Marcelo D.M.
; Vieira, Ana O.S.
; Vieira, Diego D.
; Vignoli-Silva, Márcia
; Vilar, Thaisa
; Vinhos, Franklin
; Wallnöfer, Bruno
; Wanderley, Maria G.L.
; Wasshausen, Dieter
; Watanabe, Maurício T.C.
; Weigend, Maximilian
; Welker, Cassiano A.D.
; Woodgyer, Elizabeth
; Xifreda, Cecilia C.
; Yamamoto, Kikyo
; Zanin, Ana
; Zenni, Rafael D.
; Zickel, Carmem S
.
Resumo Um levantamento atualizado das plantas com sementes e análises relevantes acerca desta biodiversidade são apresentados. Este trabalho se iniciou em 2010 com a publicação do Catálogo de Plantas e Fungos e, desde então vem sendo atualizado por mais de 430 especialistas trabalhando online. O Brasil abriga atualmente 32.086 espécies nativas de Angiospermas e 23 espécies nativas de Gimnospermas e estes novos dados mostram um aumento de 3% da riqueza em relação a 2010. A Amazônia é o Domínio Fitogeográfico com o maior número de espécies de Gimnospermas, enquanto que a Floresta Atlântica possui a maior riqueza de Angiospermas. Houve um crescimento considerável no número de espécies e nas taxas de endemismo para a maioria dos Domínios (Caatinga, Cerrado, Floresta Atlântica, Pampa e Pantanal), com exceção da Amazônia que apresentou uma diminuição de 2,5% de endemicidade. Entretanto, a maior parte das plantas com sementes que ocorrem no Brasil (57,4%) é endêmica deste território. A proporção de formas de vida varia de acordo com os diferentes Domínios: árvores são mais expressivas na Amazônia e Floresta Atlântica do que nos outros biomas, ervas são dominantes no Pampa e as lianas apresentam riqueza expressiva na Amazônia, Floresta Atlântica e Pantanal. Este trabalho não só quantifica a biodiversidade brasileira, mas também indica as lacunas de conhecimento e o desafio a ser enfrentado para a conservação desta flora.
Abstract An updated inventory of Brazilian seed plants is presented and offers important insights into the country's biodiversity. This work started in 2010, with the publication of the Plants and Fungi Catalogue, and has been updated since by more than 430 specialists working online. Brazil is home to 32,086 native Angiosperms and 23 native Gymnosperms, showing an increase of 3% in its species richness in relation to 2010. The Amazon Rainforest is the richest Brazilian biome for Gymnosperms, while the Atlantic Rainforest is the richest one for Angiosperms. There was a considerable increment in the number of species and endemism rates for biomes, except for the Amazon that showed a decrease of 2.5% of recorded endemics. However, well over half of Brazillian seed plant species (57.4%) is endemic to this territory. The proportion of life-forms varies among different biomes: trees are more expressive in the Amazon and Atlantic Rainforest biomes while herbs predominate in the Pampa, and lianas are more expressive in the Amazon, Atlantic Rainforest, and Pantanal. This compilation serves not only to quantify Brazilian biodiversity, but also to highlight areas where there information is lacking and to provide a framework for the challenge faced in conserving Brazil's unique and diverse flora.
https://doi.org/10.1590/2175-7860201566411
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12.
Modulation of cell proliferation, survival and gene expression by RAGE and TLR signaling in cells of the innate and adaptive immune response: role of p38 MAPK and NF-KB
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MEDEIROS, Marcell Costa de
; FRASNELLI, Sabrina Cruz Tfaile
; BASTOS, Alliny de Souza
; ORRICO, Silvana Regina Perez
; ROSSA JUNIOR, Carlos
.
Objective: The aim of this study was to evaluate a possible synergism between AGE-RAGE and TLR4 signaling and the role of p38 MAPK and NF-kB signaling pathways on the modulation of the expression of inflammatory cytokines and proliferation of cells from the innate and adaptive immune response. Material and Methods: T lymphocyte (JM) and monocyte (U937) cell lines were stimulated with LPS and AGE-BSA independently and associated, both in the presence and absence of p38 MAPK and NF-kB inhibitors. Proliferation was assessed by direct counting and viability was assessed by a biochemical assay of mitochondrial function. Cytokine gene expression for RAGe, CCL3, CCR5, IL-6 and TNF-α was studied by RT-PCR and RT-qPCR. Results: RAGE mRNA expression was detected in both cell lines. LPS and AGE-BSA did not influence cell proliferation and viability of either cell line up to 72 hours. LPS and LPS associated with AGE induced expression of IL-6 and TNF-α in monocytes and T cells, respectively. Conclusions: There is no synergistic effect between RAGE and TLR signaling on the expression of IL-6, TNF-α , RAGE, CCR5 and CCL3 by monocytes and lymphocytes. Activation of RAGE associated or not with TLR signaling also had no effect on cell proliferation and survival of these cell types.
https://doi.org/10.1590/1678-775720130593
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13.
Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control
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Silva-Boghossian, Carina Maciel
; Orrico, Silvana Regina Perez
; Gonçalves, Daniela
; Correa, Fernanda Oliveira Bello
; Colombo, Ana Paula Vieira
.
The present study investigated the effect of non-surgical periodontal treatment (SRP) on the composition of the subgingival microbiota of chronic periodontitis (CP) in individuals with type 2 diabetes (DM2) with inadequate metabolic control and in systemically healthy (SH) individuals. Forty individuals (20 DM2 and 20 SH) with CP underwent full-mouth periodontal examination. Subgingival plaque was sampled from 4 deep sites of each individual and tested for mean prevalence and counts of 45 bacterial taxa by the checkerboard method. Clinical and microbiological assessments were performed before and 3 months after SRP. At baseline, those in the DM2 group presented a significantly higher percentage of sites with visible plaque and bleeding on probing compared with those in the SH group (p < 0.01). Those in the DM2 group presented significantly higher levels of C. rectus and P. gingivalis, and lower prevalence of P. micra and S. anginosus, compared with those in the SH group (p ≤ 0.001). At the 3-month visit, both groups showed a significant improvement in all clinical parameters (p < 0.01). Those in the DM2 group showed significantly higher prevalence and/or levels of A. gerencseriae, A. naeslundii I, A. oris, A. odontolyticus, C. sputigena, F. periodonticum, and G. morbillorum compared with those in the SH group (p ≤ 0.001). However, those in the DM2 group showed a significant reduction in the levels of P. intermedia, P. gingivalis, T. forsythia, and T. denticola (p ≤ 0.001) over time. Those in the SRP group showed improved periodontal status and reduced levels of putative periodontal pathogens at 3 months’ evaluation compared with those in the DM2 group with inadequate metabolic control.
https://doi.org/10.1590/1807-3107BOR-2014.vol28.0007
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14.
Prevalence of Candida spp. during radiographic examination in Diabetes mellitus patients
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Volpato, Flávia Cristina
; Pires, Juliana Rico
; Martinez, Isis do Rosário da Costa
; Orrico, Silvana Regina Perez
; Costa, Marciano Pires da
; Spolidório, Denise Madalena Palomari
; Gonçalves, Andréa
.
INTRODUÇÃO: Relata-se que indivíduos diabéticos são mais susceptíveis a infecções por Candida que indivíduos saudáveis, especialmente se doença periodontal estiver associada. OBJETIVO: Este estudo propôs avaliar a prevalência de colonização por Candida spp. durante o exame radiográfico em pacientes diabéticos e não diabéticos. MATERIAL E MÉTODO: Vinte e seis pacientes com Diabetes mellitus do tipo 2 e 20 pacientes sem Diabetes mellitus, apresentando periodontite crônica e Candida spp. na saliva, foram avaliados. Durante o exame radiográfico, amostras de saliva foram coletas: da mucosa oral, do filme radiográfico periapical convencional, sensor radiográfico digital (CDR) e bloco de mordida do posicionador de filmes. Unidades formadoras de colônia (cfu/mL) e identificação das leveduras do gênero Candida foram avaliadas. RESULTADO: A mucosa oral de ambos os grupos mostrou maior colonização por Candida spp. quando comparada com outras superfícies coletadas (p < 0.05). Nos pacientes diabéticos, a mucosa da região esquerda superior mostrou níveis mais altos de colonização. Nos pacientes não diabéticos, a região de molar superior direito mostrou o nível mais alto de colonização durante o exame no posicionador, no sensor e no lado do filme periapical que não fica voltado para a radiação X. Os níveis de Candida spp. na saliva foram similares entre diabéticos (média = 3.0 × 10(6)) e não diabéticos (média = 3.8 × 10(6)). CONCLUSÃO: Nenhuma diferença na colonização por Candida spp. (cfu/mL) em pacientes diabéticos e não diabéticos foi observada nas cinco superfícies coletadas e nas regiões radiográficas simuladas. Candida albicans foi a espécie prevalente de Candida spp. encontrada em todas as amostras.
INTRODUCTION: It is suggested that individuals with diabetes are more susceptible to Candida infections than healthy people, especially if periodontal infection is associated. OBJECTIVE: This study evaluated the prevalence of colonization by Candida spp. during radiographic examination in diabetic and non-diabetic patients. MATERIAL AND METHODS: Twenty-six patients with type 2 diabetes mellitus and 20 patients without diabetes mellitus, presenting chronic periodontitis and presence of Candida spp. in saliva were evaluated. During radiographic examination, samples of saliva were collected from: oral mucosa, conventional radiographic periapical film, digital x-ray sensor (CDR), and bite block of the receptor-positioning device. Colony forming units (cfu/mL) and identification of Candida yeasts were assessed. RESULT: Oral mucosa from both groups showed the highest colonization with Candida spp. if compared with others surfaces collected (p < 0.05). In diabetic patients, the mucosa of the upper left regions showed higher levels of colonization. In non-diabetic patients, the upper right molar region showed the highest level of colonization during the examination of the receptor-positioning device, the sensor and the non-sensitive film. Candida spp. levels in saliva were similar between diabetics (mean = 3.0 × 10(6)) and non-diabetics (mean = 3.8 × 10(6)). CONCLUSION: No difference in Candida spp. colonization (cfu/mL) in diabetics and non-diabetic patients was observed for the five collected surfaces and the simulated radiographic region. Candida albicans was the prevalent species of Candida spp. found on all the samples.
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15.
Induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human Inflammatory Bowel Disease
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Teixeira, Gerlinde Agate Platais Brasil
; Antunes, Danielle Mota Fontes
; Castro Júnior, Archimedes Barbosa de
; Costa, Janilda Pacheco da
; Paschoal, Patrícia Olaya
; Campos, Sylvia Maria Nicolau
; Pedruzzi, Monique de Morais Bitetti
; Araújo, Vinicius da Silva
; Andrade, Luis Antônio Botelho
; Moreno, Silvana Ramos Farias
; Nobrega, Alberto Felix Antonio da
; Cardoso, Gilberto Perez
.
Brazilian Archives of Biology and Technology
- Journal Metrics
A alergia alimentar consiste em uma reação adversa que ocorre em pessoas susceptíveis quando ingerem alimentos sensibilizantes, sendo uma das causas das Doenças Inflamatórias Intestinais (IBD). O objetivo deste estudo foi desenvolver um protocolo experimental de indução de um processo inflamatório intestinal antígeno-específico em camundongos e ratos. Foi escolhida para a indução deste processo a semente de amendoim. Os animais foram imunizados com o extrato protéico previamente à exposição com a semente in natura. Nossos resultados mostram que a imunização sistêmica com extratos protéicos de amendoim ocasiona títulos significativamente maiores de anticorpos quando comparado ao grupo controle e que os animais imunizados submetidos ao desafio com a dieta contendo exclusivamente amendoim apresentam alterações intestinais tempo-dependente similares àquelas observadas na doença celíaca. Os resultados obtidos sugerem que este modelo experimental constitui uma ferramenta conveniente para avaliar as alterações no processo inflamatório intestinal crônico antígeno-específico
Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time dependent alterations of the gut similar to celiac disease. In conclusion, results suggested that this experimental model was a convenient tool to study the evolution of alterations in chronic antigen specific gut inflammatory process.
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