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Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Synthesis and characterization of isoprene oligomers to compare different production chemical processes
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Pires, Renata Vieira

; Pessoa, Larissa Mota Barros

; Sant’Anna, Monica de Almeida de

; Fainleib, Alexander

; Nunes, Rita de Cassia Pessanha

; Lucas, Elizabete Fernandes

Polímeros

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2019, Volume 29 N. 1 elocation e2019015

Abstract: En | Text: En | PDF: En

Abstract Three methods to obtain isoprene oligomers were evaluated: chemical degradation of non-vulcanized coagulated natural rubber; chemical degradation of natural rubber latex; and oligomerization of the isoprene monomer. The products were characterized by infrared spectrometry (FTIR), nuclear magnetic resonance (NMR) and size-exclusion chromatography (SEC). All the three processes were efficient and can be controlled in order to obtain products with desired molar mass. Among the degradation processes, the reaction with the non-vulcanized rubber led to the purest products, but this process has the disadvantage of relatively higher catalyst cost of the catalyst. Reactions of isoprene with free radical initiation produced oligomers under specific conditions: low isoprene concentration, low initiator concentration, and xylene as solvent. The results discussed here allows the readers to have a chemistry overview and experimental insights about different chemical routes to obtain isoprene oligomers, compiled together in the same work. It shall be helpful for applied chemistry researches.

https://doi.org/10.1590/0104-1428.04418 1391 downloads

Tinnitus and sound intolerance: evidence and experience of a Brazilian group
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Onishi, Ektor Tsuneo

; Coelho, Cláudia Couto de Barros

; Oiticica, Jeanne

; Figueiredo, Ricardo Rodrigues

; Guimarães, Rita de Cassia Cassou

; Sanchez, Tanit Ganz

; Gürtler, Adriana Lima

; Venosa, Alessandra Ramos

; Sampaio, André Luiz Lopes

; Azevedo, Andreia Aparecida

; Pires, Anna Paula Batista de Ávila

; Barros, Bruno Borges de Carvalho

; Oliveira, Carlos Augusto Costa Pires de

; Saba, Clarice

; Yonamine, Fernando Kaoru

; Medeiros, Ítalo Roberto Torres de

; Rosito, Letícia Petersen Schmidt

; Rates, Marcelo José Abras

; Kii, Márcia Akemi

; Fávero, Mariana Lopes

; Santos, Mônica Alcantara de Oliveira

; Person, Osmar Clayton

; Ciminelli, Patrícia

; Marcondes, Renata de Almeida

; Moreira, Ronaldo Kennedy de Paula

; Torres, Sandro de Menezes Santos

Brazilian Journal of Otorhinolaryngology

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mar 2018, Volume 84 N. 2 Pages 135 - 149

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução Zumbido e intolerância a sons são queixas frequentes e subjetivas que podem ter impacto na qualidade de vida do paciente. Objetivo Apresentar uma revisão dos principais pontos, inclusive conceitos, fisiopatologia, diagnóstico e abordagem do paciente com zumbido e sensibilidade a sons. Método Revisão da literatura com levantamento bibliográfico na base de dados da LILACS, SciELO, Pubmed e MEDLINE. Foram selecionados artigos e capítulos de livros sobre zumbido e sensibilidade a sons. Os diversos tópicos foram discutidos por um grupo de profissionais brasileiros e as conclusões, descritas. Resultado A prevalência de zumbido tem aumentado ao longo dos anos, muitas vezes associado a perda auditiva, fatores metabólicos e erros alimentares. A avaliação médica deve ser feita minuciosamente no sentido de orientar a solicitação de exames subsidiários. Os tratamentos disponíveis atualmente variam de medicamentos ao uso de sons com características específicas e técnicas de meditação, com resultados variáveis. Conclusão Foi apresentada uma revisão sobre os temas que permitindo ao leitor uma visão ampla da abordagem dos pacientes com zumbido e sensibilidade auditiva baseada em evidências científicas e experiência nacional.

Abstract Introduction Tinnitus and sound intolerance are frequent and subjective complaints that may have an impact on a patient's quality of life. Objective To present a review of the salient points including concepts, pathophysiology, diagnosis and approach of the patient with tinnitus and sensitivity to sounds. Methods Literature review with bibliographic survey in LILACS, SciELO, Pubmed and MEDLINE database. Articles and book chapters on tinnitus and sound sensitivity were selected. The several topics were discussed by a group of Brazilian professionals and the conclusions were described. Results The prevalence of tinnitus has increased over the years, often associated with hearing loss, metabolic factors and inadequate diet. Medical evaluation should be performed carefully to guide the request of subsidiary exams. Currently available treatments range from medications to the use of sounds with specific characteristics and meditation techniques, with variable results. Conclusion A review on tinnitus and auditory sensitivity was presented, allowing the reader a broad view of the approach to these patients, based on scientific evidence and national experience.

https://doi.org/10.1016/j.bjorl.2017.12.002 28893 downloads

Qualitative analysis of the viability of autogenous fat grafts grafted in different environments of interstitial pressure. Preliminary results and description of a new experimental model in mini-pigs
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Arruda, Eduardo Gustavo Pires de

; Munhoz, Alexandre Mendonça

; Matsumoto, Walter

; Ueda, Thiago

; Coudry, Renata de Almeida

; Gemperli, Rolf

Acta Cirúrgica Brasileira

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nov 2017, Volume 32 N. 11 Pages 891 - 902

Abstract: En | Text: En | PDF: En

Abstract Purpose: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. Methods: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure “under tension”. A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP. Results: The mean operative time was 236 min (210 - 272 min). All the AFG and muscular segments were removed successfully. Average interstitial pressure CP and H were 3 and 10.6 mmHg respectively. The AFG were biopsied for histopathological analysis 30 days after graft. Hematoxylin-eosin staining and immunohistochemical analyzes (TNF-alpha, CD31 and Perilipine with monoclonal antibodies) were employed. Conclusion: The data show that minipigs model could be used as a recipient site for autologous fat graft techniques and allow the development of studies to explore the AFG intake and pathophysiology response.

https://doi.org/10.1590/s0102-865020170110000001 1145 downloads

Montreal Cognitive Assessment (MoCA) no rastreio de comprometimento cognitivo leve (CCL) em pacientes com doença renal crônica (DRC) pré-dialítica
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Paraizo, Marilise de Andrade

; Almeida, Ana Laura Maciel

; Pires, Leopoldo Antônio

; Abrita, Renata Silva Almeida

; Crivellari, Mary Hellen Teixeira

; Pereira, Beatriz dos Santos

; Fernandes, Natália Maria da Silva

; Bastos, Marcus Gomes

Brazilian Journal of Nephrology

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mar 2016, Volume 38 N. 1 Pages 31 - 41

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Indivíduos com doença renal crônica (DRC) têm grande risco de desenvolver comprometimento cognitivo (CC), inicialmente leve (CCL), passível de identificação, mas ainda subdiagnosticado e subtratado. O Montreal Cognitive Assessment (MoCA) vem sendo indicado para rastreio de CCL na DRC. Objetivo: Avaliar o CCL em indivíduos com DRC pré-dialítica. Métodos: O estudo foi realizado em 72 indivíduos, não idosos, com DRC nos estágios pré-dialíticos. A avaliação neuropsicológica incluiu: o teste de cognição global MoCA; o teste do relógio (TDR); o Digit Span ordem direta (DOD) e inversa (DOI); o teste de fluência verbal (FV), fonêmica (FAS) e semântica (animais); o punho-borda-mão (PBM); e de memória 10 figuras. Resultados: A média de idade dos participantes foi de 56,74 ± 7,63 anos, com predominância de homens (55,6%), com escolaridade ≥ 4 anos (84,3%), a maioria com DRC 1, 2 e 3a e 3b (67,6%), hipertensa (93,1%) e diabética (52,1%). O CC (MoCA ≤ 24) foi observado em 73,6% dos usuários. Não encontramos associação das variáveis demográficas e clínicas com CC, mas tendência de associação com a idade (p = 0,07), com a escolaridade (p = 0,06) e com o DM (0,06). Os testes de função executiva, TDR, DOI e PBM, isoladamente, apresentaram boa sensibilidade e valor preditivo negativo comparados ao MoCA para a identificação de CC e, em conjunto, foram capazes de predizer o resultado do MoCA. Conclusão: O CCL é frequente em usuários não idosos com DRC pré-dialítica. O TDR, DOI e PBM associados são equivalentes ao MoCA na identificação do CC nessa população, sugerindo comprometimento de funções executivas.

Abstract Introduction: Individuals with chronic kidney disease (CKD) are at higher risk of developing cognitive impairment (CI), initially mild (MCI), potentially identifiable, but still poorly diagnosed and treated. The Montreal Cognitive Assessment (MoCA) has been indicated for MCI screening in CKD. Objective: To assess MCI in patients with CKD not yet on dialysis. Methods: Study conducted in 72 non-elderly subjects with pre-dialysis CKD. The neuropsychological assessment included: The global cognitive assessment test MoCA; the clock drawing (CD); the digit span forward (DSF) and reverse (DSR); phonemic verbal (VF) fluency (FAS) and semantics (animals); the fist-edge-palm (FEP); and the memory 10 pictures. Results: The average age of the participants was 56.74 ± 7.63 years, with predominance of male sex (55.6%), mainly with ≥ 4 years of education (84.3%), with CKD cathegories 1, 2 and 3a and 3b (67.6%), hypertension (93.1%) and diabetes mellitus (52.1%). MCI (MoCA ≤ 24) was observed in 73.6% of the patients. We did not find association among MCI with demographic and clinical variables, but a tendency to association with age (p = 0.07), educational level (p = 0.06) and diabetes (0.06). The executive function tests CD, DS-reverse and FEP, individually were able to identify CI with good sensibility and negative predictive value compared to MoCA and together, showed the same capability to identify MCI when compared to MoCA. Conclusion: The MCI is common in non-elderly patients with CKD not yet on dialysis. Together, the CD, DSR and FEP showed similar performance in identify MCI in this population when compared to MoCA, suggesting impairment of executive functions.

https://doi.org/10.5935/0101-2800.20160006 19716 downloads

Rendimento de carcaça e qualidade da carne de codornas de corte alimentadas com rações de diferentes níveis de proteína e suplementadas com aminoácidos essenciais
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Pinheiro, Sandra Regina Freitas

; Dumont, Mariana Almeida

; Pires, Aldrin Vieira

; Boari, Cleube Andrade

; Miranda, Jéssica Amaral

; Oliveira, Renata Gomes de

; Ferreira, Cátia Borges

Ciência Rural

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feb 2015, Volume 45 N. 2 Pages 292 - 297

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivou-se avaliar diferentes níveis de proteína bruta e a suplementação de aminoácidos essenciais sobre o rendimento de carcaça e a qualidade da carne de peito de codornas de corte dos 28 aos 42 dias de idade. O delineamento utilizado foi inteiramente casualizado, com cinco tratamentos (19, 21, 23, 25, 27% PB), cinco repetições e 12 aves (seis fêmeas e seis machos) cada. Aos 42 dias de idade, quatro aves de cada parcela foram abatidas e avaliadas quanto ao rendimento de carcaça quente (RCQ) e resfriada (RCF), de peito (RP), de coxa e sobrecoxa (RCS), potencial hidrogeniônico (pH), capacidade de retenção de água (CRA), perda de peso por cozimento (PPC), cor e luminosidade e maciez objetiva (MO) do músculo. Observou-se efeito dos níveis de PB em todas as variáveis, exceto para CRA e luminosidade da carne de peito. Dessa forma, conclui-se que 19% de PB e a suplementação de aminoácidos essenciais na ração de codornas de corte seja satisfatório para o rendimento de carcaça, de peito e de qualidade da carne.

The objective was to evaluate different levels of crude protein and essential amino acid supplementation on carcass yield and meat quality of breast meat quails from 28 to 42 days old. The experimental design was in a completely randomized with five treatments (19, 21, 23, 25, 27% CP), five replicates and 12 birds (six females and six males) each. At 42 days of age four birds from each treatment were slaughtered and evaluated for hot carcass yield (HCY) and cooled (CCY), breast (BY), thigh and drumstick (TDY), hydrogen potential (HP), water holding capacity (WHC), weight loss by cooking (WLC), color and luminosity and objective tenderness (OT) muscle. It was observed effect of CP levels on all variables except for WHC and luminosity of the breast meat. Thus, it is concluded that 19% CP and essential amino acids supplementation in the diet of meat quails is satisfactory to the carcass, breast, and meat quality.

https://doi.org/10.1590/0103-8478cr20120327 5673 downloads

A search for Clostridium difficileribotypes 027 and 078 in Brazil
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Monteiro, Alexandre de Almeida

; Pires Neto, Renata

; Persson, Søren

; Rodrigues Filho, Edison Moraes

; Pasqualotto, Alessandro Comarú

Brazilian Journal of Infectious Diseases

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dec 2014, Volume 18 N. 6 Pages 672 - 674

Abstract: En | Text: En | PDF: En

Toxigenic strains of Clostridium difficile may be disseminating. Here we prospectively screened patients with nosocomial diarrhoea in two hospitals in Brazil. To identify C. difficile polymerase chain reaction ribotypes 027/078 strains, we used high resolution melting and multiplex polymerase chain reaction. Among 116 screened patients, 11 were positive for C. difficile. The polymerase chain reaction ribotypes 027/078 strains were not identified in this study.

https://doi.org/10.1016/j.bjid.2014.08.004 1173 downloads

Avaliação hormonal e de marcadores séricos em pacientes com abortamento
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Murta, Eddie Fernando Candido

; Carloni, Renata Almeida Pires Marcelo Balabem

; Dair, Elizabete Lilian

Revista Brasileira de Ginecologia e Obstetrícia

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mar 1998, Volume 20 N. 2 Pages 91 - 95

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Estudos têm demonstrado a utilização de glicoproteínas e hormônios para prognosticar a evolução de uma gravidez complicada por ameaça de abortamento. Entretanto, alguns resultados ainda são duvidosos. Portanto, o objetivo deste estudo foi avaliar as dosagens de CA-125, CA-19.9, CA-15.3, beta-hCG, estradiol, progesterona, alfa-fetoproteína e antígeno cárcino-embrionário no sangue periférico de mulheres com abortamento inevitável (n=18) e com ameaça de abortamento que posteriormente evoluíram para o abortamento (n=6) no prazo de 1 a 26 dias. O grupo controle foi constituído de mulheres grávidas normais com idade gestacional semelhante (n=7). Todas as pacientes foram atendidas no Hospital Escola e/ou Ambulatório de Ginecologia e Obstetrícia da Faculdade de Medicina do Triângulo Mineiro. Os resultados demonstraram que as dosagens de CA-125 nos grupos controle, abortamento inevitável e ameaça de abortamento foram, respectivamente: 24,7 ± 13,4 UI/ml; 153,9 ± 43,3 UI/ml e 17,4 ± 2,6 UI/ml sendo estatisticamente significante a diferença entre o grupo com abortamento inevitável em comparação com os outros grupos. A dosagem de CA-19.9 foi significantemente menor no grupo com abortamento inevitável em relação ao grupo com ameaça de abortamento (6,6 ± 1,4 UI/ml versus 20,2 ± 11,4 UI/ml). A dosagem de estradiol foi significantemente menor no grupo com abortamento inevitável em comparação com o grupo controle (1.327 ± 1.015 ng/ml versus 10.774 ± 9.244 ng/ml). As pacientes com ameaça de abortamento e com abortamento inevitável apresentaram níveis mais baixos de progesterona que o grupo controle, respectivamente: 17,38 ± 9,4 ng/ml; 18,3 ± 8,9 ng/ml e 60,4 ± 26,8 ng/ml. Concluímos que as dosagens de progesterona, CA-19.9 e do beta-hCG podem servir como prognóstico de evolução de uma gravidez inicial complicada com ameaça de abortamento.

Predicting pregnancy outcome from one or more maternal serum factors has been the subject of numerous investigations with controversial results. The aim of this study was to evaluate the serum levels of CA-125, CA-19.9, CA-15.3, beta-hCG, estradiol, progesterone, alpha-fetoprotein and CEA in women with abortion (n=18) and with pregnancy complicated by bleeding (n=6), in comparison to the serum levels of the control group (n=7). The results showed that the serum levels of CA-125 were significantly increased in the abortion group (153.9 ± 43.3 IU/ml), but no difference was detected in pregnancy complicated by bleeding (17.4 ± 2.6 IU/ml), as compared to control (24.7 ± 13.4 IU/ml). However, high serum levels of CA-19.9 were found in the group with pregnancy complicated by bleeding in comparison with the abortion group (20.2 ± 11.4 IU/ml versus 6.6 ± 1.4 IU/ml, respectively). In relation to hormone serum levels, both, the abortion (17.38 ± 9.4 ng/ml) and bleeding (18.3 ± 8.9 ng/ml) groups showed lower serum levels of progesterone, as compared to control (60.4 ± 26.8 ng/ml). Besides, women with abortion had additional low estradiol serum levels, when compared to controls (1,327 ± 1,015 ng/ml versus 10,774 ± 9,244 ng/ml). It was concluded that the serum levels of progesterone, CA-19.9 and beta-hCG seem to add valuable information to the evaluation of a pregnancy complicated by bleeding.

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Influência da idade materna do período gestacional e do número de gestações na infecção pelo papilomavirus humano
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Murta, Eddie Fernando Candido

; Souza, Maria Azniv Hazarabedian de

; Adad, Sheila Jorge

; Pires, Renata Almeida

; Matthes, Ângelo Gustavo Zucca

Revista Brasileira de Ginecologia e Obstetrícia

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feb 1998, Volume 20 N. 1 Pages 33 - 35

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Foram analisadas as informações referentes a 93 mulheres grávidas com exame Papanicolaou sugerindo infecção pelo papilomavirus humano (HPV) segundo critério de Schneider et al., com o objetivo de estudar o efeito da idade materna, do período gestacional e do número de gravidezes sobre a incidência desta infecção. O grupo controle consistiu de 93 mulheres grávidas sem sinais citológicos de infecção pelo HPV. Os resultados demonstraram que a infecção pelo HPV está associada à mulher grávida abaixo dos 20 anos de idade; entretanto, não houve relação com a idade gestacional e o número de gravidezes.

We have analyzed 93 pregnant women with Papanicolaou smears suggesting human papillomavirus (HPV) infection (Schneider et al's criteria) with the purpose of studying the effect of maternal age, stage of pregnancy and number of pregnancies on the incidence of this infection. The control group consisted of 93pregnant women with Papanicolaou smears not suggestive of HPV infection. The results demonstrated that HPV infection is associated with pregnant women under 20 years of age, but no differences were found regarding stage and number of pregnancies.

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