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Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response.

https://doi.org/10.1016/j.abd.2023.03.002

Post-discharge all-cause mortality in COVID-19 recovered patients hospitalized in 2020: the impact of chronic kidney disease
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Lomba, Guilherme Schittine Bezerra

; Silva, Pedro Henrique Abreu da

; Rosário, Natalia Fonseca do

; Medeiros, Thalia

; Alves, Lilian Santos

; Silva, Andrea Alice

; Almeida, Jorge Reis

; Lugon, Jocemir Ronaldo

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e1

Abstract: En | Text: En | PDF: En

ABSTRACT In Brazil, the COVID-19 burden was substantial, and risk factors associated with higher in-hospital mortality rates have been extensively studied. However, information on short-term all-cause mortality and the factors associated with death in patients who survived the hospitalization period of acute SARS-CoV-2 infection is limited. We analyzed the six-month post-hospitalization mortality rate and possible risk factors of COVID-19 patients in a single center in Brazil. This is a retrospective cohort study focused on a six-month follow-up. The exclusion criteria were death during hospitalization, transference to another hospital, and age under 18. We collected data from the charts of all hospitalized patients from March 2020 to December 2020 with a positive RT-PCR test for SARS-CoV-2, resulting in a sample size of 106 patients. The main outcome was death after hospitalization, whereas comorbidities and demographics were evaluated as risk factors. The crude post-hospitalization death rate was 16%. The first 30 days of follow-up had the highest mortality rate. In a Cox regression model for post-hospitalization mortality, previous chronic kidney disease (HR, 4.06, 95%CI 1.46 – 11.30) and longer hospital stay (HR 1.01, 95%CI 1.00 – 1.02) were the only factors statistically associated with death. In conclusion, a high six-month all-cause mortality was observed. Within the six-month follow-up, a higher risk of death was observed for patients who had prior CKD and longer hospital stay. These findings highlight the importance of more intensive medical surveillance during this period.

https://doi.org/10.1590/s1678-9946202466001

Resistance Training Improves the Immune Response, Mainly Associated with CD8+ T Lymphocytes and B Lymphocytes, in Mice
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Pedro, Fernanda Cristina

; Oliveira, Marina Martins de

; Andrade, Rafaella Silva

; Costa, Anna Cecília Trolesi Reis Borges

; Pereira, Carine Rodrigues

; Oliveira, Pedro Felipe Rodrigues e

; Macari, Soraia

; Coimbra, Cândido Celso

; Dorneles, Elaine Maria Seles

; Pereira, Luciano José

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24220284

Abstract: En | Text: En | PDF: En

Abstract Studies investigating the effects of different modalities of exercises on the immune system are scarce. Therefore, the aim of this study was to compare the effects of eight weeks of resistance and aerobic training on the proliferation of T and B lymphocytes from mice. Eighteen male C56BL6/J mice were divided into groups (n=6), sedentary, aerobic, and resistance training. After 8 weeks, animals were euthanized, and their splenocytes were labeled and cultured with and without stimulation. Lymphocyte proliferation (CD4+, CD8+ and CD21/CD35+) was evaluated by flow cytometry. The mice subjected to resistance exercise exhibited greater proliferation for total, CD8+ and B lymphocytes (p<0.05), but not CD4+ cells (p>0.05), compared with their sedentary counterparts. We found significant correlations between maximum load and total, CD8+ and B lymphocytes proliferation rates (p<0.05). In conclusion, our results showed that resistance training promoted an improvement in the immune response associated with CD8+ and B lymphocytes.

https://doi.org/10.1590/1678-4324-2024220284

Centros Especializados em Reabilitação: avaliando os desafios à implementação do modelo biopsicossocial nas práticas assistenciais à pessoa com deficiência
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Biz, Maria Cristina Pedro

; Santos, Maria da Conceição dos

; Reis, Fernanda

; Nicolau, Stella Maris

; Furtado, Juarez Pereira

Interface - Comunicação, Saúde, Educação

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2024, Volume 28 elocation e230178

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Evaluamos en conjunto con profesionales de los servicios, los desafíos para la implementación del modelo biosicosocial en los centros especializados en rehabilitación. Por medio de la articulación de la Evaluación de Cuarta Generación y Rueda de Conversación (Método Paideia), abordamos los modelos implementados de asistencia a la persona con discapacidad, partiendo de las siguientes cuestiones: trabajar en rehabilitación; historial médico y evaluación; atención compartida y calificación del alta. Del contenido de las ruedas surgieron tres categorías empíricas: el proceso de trabajo en rehabilitación; el proceso en red; el modelo de cuidado. La identificación de obstáculos y facilitadores podrá favorecer la plena implementación del modelo biosicosocial en la atención a las personas con discapacidad, generando subsidios para el avance hacia la integralidad del cuidado a las personas con discapacidad representado en este modelo.

We assessed challenges in implementing the biopsychosocial model in specialized rehabilitation centers together with the professionals working in these services. Using fourth generation assessment and conversation circles (the Paideia method), we explored models of care for people with disabilities focusing on the following issues: working in rehabilitation; health records and evaluation; shared appointments; and improving discharge. Three empirical categories emerged from the conversation circles: rehabilitation work processes; the network-based approach; and the care model. The identification of constraints and enabling factors can help promote the effective implementation of the biopsychosocial model, generating important insights to help drive progress towards the delivery of comprehensive care to people with disabilities represented in this model.

Avaliamos, em conjunto com profissionais dos serviços, os desafios à implementação do modelo biopsicossocial nos Centros Especializados em Reabilitação. Por meio da articulação da Avaliação de Quarta Geração e Roda de Conversa (Método Paideia), abordamos os modelos implementados de assistência à pessoa com deficiência, partindo das seguintes questões: trabalhar em reabilitação; prontuário e avaliação; atendimento compartilhado e qualificação da alta. Do conteúdo das rodas emergiram três categorias empíricas: o processo de trabalho em reabilitação; o trabalho em rede; o modelo de cuidado. A identificação de entraves e facilitadores poderá favorecer a plena implementação do modelo biopsicossocial na atenção às pessoas com deficiência, gerando subsídios para o avanço rumo à integralidade do cuidado às pessoas com deficiência representado neste modelo.

https://doi.org/10.1590/interface.230178

Delirium and pain in patients in the immediate postoperative period of cardiac surgery: prevalence and associated risk factors
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Baltazar, Luiz Fernando Sposito Ribeiro

; Reis, Gabriel Baeta Branquinho

; Paiva, Arthur Marot de

; Silva, Pedro Guimarães Moreira da

; Souza, Artur Henrique de

; Gardenghi, Giulliano

BrJP

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dec 2023, Volume 6 N. 4 Pages 398 - 403

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND AND OBJECTIVES: Delirium is an acute mental status change, with fluctuating course and high incidence in cardiac surgery (CS) post-operative (PO) period. Delirium can lead to short and long-term consequences. The aim of this study was to assess the prevalence of delirium and pain and their risk factors on the 1st PO day after CS. METHODS: This was a cross-sectional analytical research. To determine the presence of PO delirium, the Confusion Assessment Method modified for Intensive Care Unit setting (CAM-ICU) and the Richmond Agitation Sedation Scale (RASS) were used. PO pain was analyzed using the Visual Analogue Pain Scale (VAS) and the presence of neuropathic components was analyzed using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale. After bedside analysis, patients were divided into Delirium (D) and Without Delirium (WD) groups. RESULTS: The total number of patients was 79. The prevalence of delirium was 16.5% (95% CI = 9.06 - 26.49%) and the mean number of comorbidities in the preoperative period was a significant risk factor for the occurrence of delirium (D =4.15±2.37 versus WD=2.96±1.78, p: 0.04). Another significant risk factor was the group older than 65 years of age, with the occurrence of delirium 1.45 times higher (PR=1.12-1.88, p: 0.0014). Regarding pain evaluation, 72.15% (95% CI 60.93 - 81.65%) reported it in the 1st PO day. CONCLUSION: The prevalence of delirium was similar to previous studies. The number of previous comorbidities and advanced age were risk factors for delirium. Pain was present predominantly over the sternotomy incision region.

RESUMO JUSTIFICATIVA E OBJETIVOS: Delirium é uma alteração aguda do estado mental, com curso flutuante e alta incidência no pós-operatório (PO) de cirurgia cardíaca (CC). O delirium pode levar a consequências a curto e longo prazo. O objetivo deste estudo foi avaliar a prevalência de delirium e dor e seus fatores de risco no 1º dia PO após CC. MÉTODOS: Trata-se de um estudo transversal analítico. Para determinar delirium no PO, foram utilizados o Confusion Assessment Method modificado para ambiente de Unidade de Terapia Intensiva (CAM-UTI) e a Richmond Agitation Sedation Scale (RASS). A dor PO foi analisada por meio da Escala Analógica Visual (EAV) e a presença de componentes neuropáticos foi analisada por meio da Escala de Avaliação de Sintomas e Sinais Neuropáticos de Leeds (LANSS). Após análise, os pacientes foram divididos nos grupos Delirium (D) e Sem Delirium (SD). RESULTADOS: Foram estudados 79 pacientes. A prevalência de delirium foi de 16,5% (IC 95%=9,06-26,49%) e o número médio de comorbidades no pré-operatório foi um fator de risco significativo para a ocorrência de delirium (D=4,15±2,37 versus SD=2,96±1,78, p: 0,04). Outro fator de risco foi o grupo com mais de 65 anos, com ocorrência de delirium 1,45 vezes maior (RP=1,12-1,88, p: 0,0014). Em relação à avaliação da dor, 72,15% (IC 95% 60,93-81,65%) a relataram no 1º dia PO. CONCLUSÃO: A prevalência de delirium foi semelhante à de estudos anteriores. O número de comorbidades prévias e a idade avançada foram fatores de risco para delirium. A dor estava presente predominantemente na região da incisão da esternotomia.

https://doi.org/10.5935/2595-0118.20230080-en

Resiliência, depressão e autoeficácia entre profissionais de enfermagem brasileiros na pandemia de COVID-19
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Sousa, Laelson Rochelle Milanês

; Leoni, Pedro Henrique Tertuliano

; Carvalho, Raphael Augusto Gir de

; Ventura, Carla Aparecida Arena

; Silva, Ana Cristina de Oliveira e

; Reis, Renata Karina

; Gir, Elucir

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 2941 - 2950

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste artigo é analisar os níveis de resiliência, depressão e autoeficácia entre profissionais de enfermagem brasileiros na pandemia de COVID-19. Estudo transversal analítico realizado entre os meses de outubro e dezembro de 2020. Foram empregados o teste T de Student, a análise de variância e a regressão linear múltipla com o objetivo de investigar em que medida os dois grandes fatores (resiliência e autoeficácia) impactavam nos níveis de depressão. Participaram do estudo 8.792 profissionais de enfermagem, 5.124 (58,8%) tiveram baixos níveis de resiliência. A média da pontuação geral para “depressão” foi de 0,74 e variou de 0,59 a 0,80. A média da pontuação geral para “autoeficácia” foi de 0,68 e variou de 0,56 a 0,80. Quanto aos preditores de depressão, a variável que mais fortemente impactou os níveis de depressão foi resiliência, explicando 6,6% do desfecho (p < 0,001, R2 Ajustado = 0,066). Os participantes deste estudo tiveram, em geral, baixos níveis de resiliência e autoeficácia e maiores pontuações médias para depressão. Os níveis de resiliência impactaram a variável depressão. Urge a necessidade de ações voltadas para a promoção da saúde psicológica de profissionais de enfermagem inseridos em contextos pandêmicos.

Abstract This aim of this study was to analyze levels of resilience, depression and self-efficacy among Brazilian nursing professionals during the COVID-19 pandemic. We conducted an analytical cross-sectional study between October and December 2020. Student’s t test, analysis of variance and multiple linear regression were used to investigate the impact of two main factors (Resilience and Self-efficacy) on depression. A total of 8,792 nursing professionals participated in the study; 5,124 (58.8%) had low levels of resilience. The mean overall score for Depression was 0.74, ranging from 0.59 to 0.80, while the mean overall score for Self-efficacy was 0.68, ranging from 0.56 to 0.80. The variable that had the strongest impact on depression levels was Resilience, explaining 6.6% of the outcome (p < 0.001, AdjustedR2 = 0.066). In general, respondents had low levels of resilience and self-efficacy and showed high mean depression scores. Level of resilience had an impact on depression. The findings reveal an urgent need for actions to promote the psychological health of nursing professionals working in crisis situations such as pandemics.

https://doi.org/10.1590/1413-812320232810.09852023

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
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Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

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oct 2023, Volume 49 N. 5 Pages 580 - 589

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Resiliência, depressão e autoeficácia entre profissionais de enfermagem brasileiros na pandemia de COVID-19
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Sousa, Laelson Rochelle Milanês

; Leoni, Pedro Henrique Tertuliano

; Carvalho, Raphael Augusto Gir de

; Ventura, Carla Aparecida Arena

; Silva, Ana Cristina de Oliveira e

; Reis, Renata Karina

; Gir, Elucir

Ciência & Saúde Coletiva

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oct 2023, Volume 28 N. 10 Pages 2941 - 2950

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-812320232810.09852023

PREVALENCE OF COMORBIDITIES IN PATIENTS WITH CHAGASIC MEGAESOPHAGUS
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PAIVA, Arthur Marot de

; REIS, Gabriel Baeta Branquinho

; PERILLO, Pedro Henrique de Ávila

; SOUZA, Diogo Henrique Saliba

; OLIVEIRA, Enio Chaves de

; REZENDE FILHO, Joffre

Arquivos de Gastroenterologia

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sep 2023, Volume 60 N. 3 Pages 322 - 329

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: This study aimed to evaluate the prevalence of some epidemiologically important comorbidities in patients with Chagas megaoesophagus in relation to the population without megaoesophagus, and whether this condition would be a protective or a risk factor for the conditions analysed. Methods: This observational descriptive study collected data from the medical records of patients with a previous diagnosis of megaoesophagus (timing: from 2005 to 2020). The patients were divided by age into a general (all ages) and an older group (aged 60 years or more). Associations were searched for four main areas/systems/involvements: cardiovascular, respiratory, endocrine and neurological. Results: The general group included 546 patients and the older group included 248 patients. As for the prevalence of comorbidities in the general group, the three most prevalent diseases were hypertension, with 44.3% (CI95%: 40.21-48.51%); dyslipidaemia, with 17.8% (CI95%: 14.79-21.19%); and heart failure, with 15.2% (CI95%: 12.43-18.45%). Similar to that in the general group, the most prevalent comorbidities in the group of older patients were hypertension, dyslipidaemia, and heart failure. Conclusion: Systemic arterial hypertension, dyslipidaemia, and heart failure were the most prevalent comorbidities in this population. The lower prevalence of diabetes mellitus and Alzheimer’s disease suggests the association of enteric nervous system denervation and requires further investigation.

RESUMO Objetivo: Este estudo teve como objetivo avaliar a prevalência de algumas comorbidades epidemiologicamente importantes em pacientes com megaesôfago chagásico em relação à população sem o megaesôfago e se essa condição seria um fator protetor ou de risco para as condições analisadas. Métodos: Este estudo descritivo observacional coletou dados de prontuários de pacientes com diagnóstico prévio de megaesôfago (período: de 2005 a 2020). Os pacientes foram divididos por idade em um grupo geral (todas as idades) e um grupo idoso (60 anos ou mais). Foram pesquisadas associações para quatro áreas/sistemas/envolvimentos principais: cardiovascular, respiratório, endócrino e neurológico. Resultados: O grupo geral incluiu 546 pacientes e o grupo idosos incluiu 248 pacientes. Quanto à prevalência de comorbidades no grupo geral, as três doenças mais prevalentes foram hipertensão, com 44,3% (IC95%: 40,21-48,51%); dislipidemia, com 17,8% (IC95%: 14,79-21,19%); e insuficiência cardíaca, com 15,2% (IC95%: 12,43-18,45%). Assim como no grupo geral, as comorbidades mais prevalentes no grupo de idosos foram hipertensão, dislipidemia e insuficiência cardíaca. Conclusão: Hipertensão arterial sistêmica, dislipidemia e insuficiência cardíaca foram as comorbidades mais prevalentes nessa população. A menor prevalência de diabetes mellitus e doença de Alzheimer sugere uma associação de denervação do sistema nervoso entérico e requer mais investigação.

https://doi.org/10.1590/s0004-2803.230302023-29

10.

Fitting Structure-Data Files (.SDF) Libraries to Progenesis QI Identification Searches
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Sanches, Pedro H. G.

; Oliveira, Danilo C. de

; Reis, Ivan G. M. dos

; Fernandes, Anna M. A. P.

; Silva, Alex A. R.

; Eberlin, Marcos N.

; Carvalho, Patrícia O.

; Duarte, Gustavo H. B.

; Porcari, Andreia M.

Journal of the Brazilian Chemical Society

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jul 2023, Volume 34 N. 7 Pages 1013 - 1019

Abstract: En | Text: En | PDF: En

Progenesis QI (PQI) is a multiplatform bioinformatics tool that facilitates the identification workflow for metabolomics experiments. PQI uses fragmentation data provided by MassBank of North America (MoNA) libraries, among others, for metabolite annotation. However, PQI does not officially support MoNA libraries and other libraries based on structure-data files (.sdf). This paper describes the development and application of a software named MoNA to Progenesis QI Library Converter, allowing PQI and MoNA by correcting the fragmentation data of the library for Progenesis readability. We evaluated several public experimental datasets, including human plasma, plant extracts, cultured cells, bacteria, rat serum, and rat hippocampus. The results showed that it is mandatory to proceed with file conversion of each library to allow PQI to access fragmentation information from .msp (main spectra profile) files. This step is highly recommended to improve the identification level of the metabolites.

https://doi.org/10.21577/0103-5053.20230016

11.

Painéis aglomerados com resíduo de Pinus caribaea var. caribaea com adesivo bicomponente sustentável
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Souza, Matheus Viana de

; Silva, Sérgio Augusto Mello da

; Cazella, Pedro Henrique da Silva

; Rodrigues, Felipe Reis

; Carneiro, Tainah Eduarda Boian

; Pinto, Edna Moura

; Martins, Aline Redondo

; Aouada, Márcia Regina de Moura

; Christoforo, André Luis

Ambiente Construído

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jul 2023, Volume 23 N. 3 Pages 263 - 276

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This research aimed to produce and evaluate particleboard with pinus waste using two production methodologies. One applied to homogeneous panels (single layer) and another to heterogeneous panels (three layers). The panels were produced with an initial density of 0.550 g/cm³, with 10% polyurethane resin derived from castor oil (PUR) for the homogeneous panels and 12% for the heterogeneous ones. The pressing parameters were 5 MPa, with a temperature of 100 ºC and 10 min of pressing, with an interval of 30 s. The tests performed according to NBR 14810-2 (ABNT, 2018) standard. As a result, it was observed that the reorganization of the particles of the heterogeneous panels added to the increase of the adhesive were factors that improved the final properties of the panels, which are classified to be used as decoration objects and in the furniture industry, not obtaining classification of homogeneous panels.

Resumo Esta pesquisa teve como objetivo produzir e avaliar painéis aglomerados com resíduo de pinus medianteuma metodologia de produçãoaplicada para painéis homogêneos e outra para heterogêneos. Os painéis homogêneos e heterogêneos foram produzidos com densidade inicial de 0,550 g/cm³ e com 10% e 12% de resina de poliuretano derivado do óleo de mamona (PUR) respectivamente. Os parâmetros de prensagem foram de 5 MPa, com temperatura de 100 ºC e 10 min de prensagem, com um intervalo de 30 s. Os ensaios realizados seguiram a normativa NBR 14810-2 (ABNT, 2018). Observou-se que a reorganização das partículas dos painéis heterogêneos somada ao aumento do adesivo foram fatores que melhoraram as propriedades finais desses painéis, classificados para ser utilizados como objetos de decoração e na indústria moveleira, enquanto os painéis homogêneos não obtiveram classificação.

https://doi.org/10.1590/s1678-86212023000300686

12.

PAAI - Interactive online self-learning programme for patients with asthma: Protocol for co-creation and impact
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Jácome, Cristina

; Fonseca, Nancy

; Rodrigues, Tânia

; Fernandes, Silvana

; Costa, Emília Dias da

; Amaral, Rita

; Matos, Paula

; Areia, Margarida

; Dias, Liliana

; Vilaverde, Marisa

; Loureiro, Cláudia Chaves

; Boechat, José Laerte

; Reis, António Baía

; Figueiredo, Daniela

; Neves, Ana Luísa

; Simões, Pedro

; Barata, Luis Taborda

; Fonseca, João Almeida

; Sá-Sousa, Ana

Revista Portuguesa de Imunoalergologia

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jun 2023, Volume 31 N. 2 Pages 151 - 161

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Patient and Public Involvement (PPI) in research should focus on the engagement of patients/carers in every stage of the research cycle. However, the inconsistent level of education and research experience may compromise this involvement and training and support are recommended. In Portugal, consistent training to empower patients in their health decisions, or to be involved in research is neither available nor adapted for the patients and public. Our main goal is to develop and deliver the first high-quality and comprehensive online educational programme for adult patients with asthma and their carers, based on patients’/carers’ needs and preferences. The project includes four tasks. In Task 1, we will identify and organise the most important topics on asthma and health research, based on the identification of educational needs of adult patients/carers with asthma and the expertise of asthma specialists, using Delphi methodology. In Task 2, we will design and implement a high-quality, free, online self-learning programme based on reliable sources of information and on patients’/carers’ preferences. In Task 3, we will assess its feasibility, satisfaction and impact. Finally, Task 4 will be centred on the management and dissemination. Patients and carers will be actively engaged in all stages of this project as co-researchers, including the writing of this protocol. By the end of this project, we expect to have implemented the first high-quality, free-of-charge, online self-learning programme on asthma and health research, adapted for adult patients with asthma and their carers. It will be available for all patients/carers not only from Portugal but also from all Lusophone countries. This programme will empower patients and carers to increase their knowledge about the disease, develop new skills and have the opportunity to learn about research. Ultimately, it will introduce the knowledge patients/carers need to represent themselves and influence health policies in Portugal successfully.

RESUMO O envolvimento dos doentes e cidadãos na investigação (PPI) deve ocorrer em todas as etapas do ciclo de investigação. No entanto, a inconsistência nos níveis educacionais e na experiência de investigação pode ser um entrave significativo de uma participação ativa. Assim, ações de formação e suporte são recomendadas. Em Portugal, não existe formação específica para capacitar os doentes nas suas decisões de saúde, ou para se envolverem em investigação. O objetivo principal é desenvolver e tornar acessível o primeiro programa educacional online de elevada qualidade para doentes adultos com asma e seus cuidadores, com base nas suas necessidades e preferências. O projeto inclui 4 tarefas. Na tarefa 1 iremos identificar os tópicos mais importantes na área da asma e investigação em saúde, a partir da identificação das necessidades educacionais de doentes/cuidadores e da experiência de especialistas em asma, usando o método Delphi. Na tarefa 2 pretendemos desenhar e implementar um programa de elevada qualidade, gratuito e online, baseado em fontes de informação fiáveis e nas preferências de doentes/cuidadores. Na tarefa 3 vamos disseminar o programa e avaliar a sua exequibilidade, aceitabilidade e impacto. A tarefa 4 irá incidir na gestão e disseminação do projeto. Doentes e cuidadores estarão ativamente envolvidos em todas as tarefas do projeto como coinvestigadores, onde se inclui a escrita deste protocolo. No final deste projeto, esperamos ter implementado o primeiro programa de auto-aprendizagem de elevada qualidade, gratuito e online para a asma e investigação em saúde, adaptado para doentes/cuidadores com asma. Este programa irá capacitar doentes e cuidadores para aumentar o seu conhecimento sobre a doença, para desenvolver novas competências, e será uma oportunidade para aprenderem sobre investigação. Este programa permitirá também a introdução a conhecimentos necessários para doentes e cuidadores se fazerem representar e influenciarem as políticas em saúde em Portugal.

https://doi.org/10.32932/rpia.2023.04.111

13.

Effects of dietary fiber on performance and egg quality of laying hens at pre-laying and laying peak
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Andrade, Pedro Gabriel Carneiro de

; Mendonça, Marco Antonio de Freitas

; Cruz, Frank George Guimarães

; Rufino, João Paulo Ferreira

; Silva, Fernanda Moura Fernandes

; Reis, Lucas de Almeida

Acta Scientiarum. Animal Sciences

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2023, Volume 45 elocation e57534

Abstract: En | Text: En | PDF: En

ABSTRACT. This study aimed to evaluate the effects of different levels of dietary fiber on the performance and egg quality of laying hens at pre-laying and laying peak periods. The experimental period was divided into three periods: pre-laying (16 to 19 weeks of age), the start of laying (20 to 22 weeks of age) and laying peak (23 to 28 weeks of age). The experimental design was completely randomized with treatments constituted by five levels of fiber (2.00, 2.50, 3.00, 3.50, and 4.00%) in the diets, with five replicates (pens) of six birds each, totalling 180 hens. Performance and egg quality results were evaluated by polynomial regression at 5%. Fiber levels were not influenced (p >0.05) the first laying of the hens. However, levels above 2.50% of fiber provided worst (p <0.05) performance results, regardless of the period evaluated. Shortly after the start of laying, higher levels of fiber also caused a linear reduction (p <0.05) on egg weight and percentages of yolk and albumen, and an increase (p <0.05) on eggshells. Higher fiber levels caused a linear reduction (p <0.05) in the quality of the eggs, regardless of the period evaluated. It was concluded that the fiber levels did not influence the start period of the laying. Both pre-laying and start of the laying, levels above 2.5% of fiber caused a gradual worsening in performance. From the start of laying up to laying peak, levels above 2.5% of fiber also caused a gradual worsening in egg quality.

https://doi.org/10.4025/actascianimsci.v45i1.57534

14.

Cross-breastfeeding and milk donation in Brazil
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Boccolini, Cristiano Siqueira

; Reis, Neilane Bertoni dos

; Farias, Dayana Rodrigues

; Berti, Talita Lelis

; Lacerda, Elisa Maria de Aquino

; Castro, Inês Rugani Ribeiro de

; Kac, Gilberto

; Vertulli Carneiro, Letícia B.

; dos Anjos, Luiz Antonio

; Alves-Santos, Nadya Helena

; de Freitas, Maiara Brusco

; Normando, Paula

; Andrade, Pedro Gomes

; Schincaglia, Raquel Machado

Cadernos de Saúde Pública

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2023, Volume 39 Suppl. 2 elocation e00082322

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: O objetivo deste estudo foi descrever a frequência de amamentação cruzada, doação de leite humano para bancos de leite humano e recepção de leite humano dos bancos de leite humano, além de investigar a interseção entre práticas de amamentação cruzada e a doação de leite materno. Este estudo utilizou dados do Estudo Nacional de Alimentação e Nutrição Infantil (ENANI-2019), uma pesquisa populacional de base domiciliar que coletou informações de 14.558 crianças < 5 anos entre fevereiro de 2019 e março de 2020. Dados de 5.831 mães biológicas que relataram ter amamentado seu filho com menos de dois anos de idade pelo menos uma vez e que responderam às perguntas sobre amamentação cruzada, doação e recepção de leite humano nos bancos de leite humano foram inclusos. Foram estimados as prevalências e os intervalos de 95% de confiança (IC95%) para cada estratificador, considerando o desenho amostral complexo do estudo. Entre as mães de crianças com menos de dois anos que amamentaram o filho pelo menos uma vez, 21,1% praticaram a amamentação cruzada. Amamentar outra criança foi mais frequente (15,6%) do que permitir que a sua criança fosse amamentada por outra mulher (11,2%). Entre essas mulheres, 4,8% doaram leite humano para um bancos de leite humano e 3,6% relataram que seus filhos receberam leite humano doado. A doação de leite humano é uma prática recomendada pelo Ministério da Saúde e tem o potencial de salvar milhares de recém-nascidos em todo o Brasil. Em contraste, a amamentação cruzada é contraindicada devido ao risco potencial de transmissão do HIV. Há necessidade de um amplo debate sobre essas práticas no Brasil e no mundo.

Resumen: El objetivo de este estudio fue describir la frecuencia de lactancia materna cruzada, la donación de leche humana a los bancos de leche humana y la recepción de leche humana de los bancos de leche humana, además de investigar la intersección entre las prácticas de lactancia materna cruzada y la donación de leche materna. Este estudio utilizó datos del Estudio Nacional de Alimentación y Nutrición Infantil (ENANI-2019), una encuesta nacional de hogares que recopiló información de 14.558 niños < 5 años, en el periodo entre febrero de 2019 y marzo de 2020. Se incluyeron datos de 5.831 madres biológicas que reportaron haber amamantado a su hijo < 2 años, al menos una vez, y que respondieron preguntas sobre lactancia cruzada, donación y recepción de leche humana en los bancos de leche humana. Se estimaron prevalencias y los intervalos de 95% de confianza (IC95%) para cada estrato, considerando el diseño muestral complejo del estudio. Entre las madres de niños < 2 años que amamantaron a su hijo al menos una vez, el 21,1% practicaba la lactancia cruzada. Amamantar a otro hijo fue más frecuente (15,6%) que dejar que su hijo sea amamantado por otra mujer (11,2%). Entre estas mujeres, el 4,8% donó leche humana a un bancos de leche humana y el 3,6% informó que sus hijos recibieron leche humana donada. La donación de leche humana es una práctica recomendada por el Ministerio de Salud brasileño y puede salvar muchos recién nacidos en todo Brasil. Por el contrario, la lactancia cruzada está contraindicada debido al potencial riesgo de transmisión del VIH. Es necesario un amplio debate sobre estas prácticas en Brasil y en el mundo.

Abstract: The objective of this study was to describe the frequency of cross-breastfeeding, human milk donation to human milk banks and reception of human milk from human milk banks, and to investigate the intersection between cross-breastfeeding and breast milk donation practices. This study used data from the national household-based survey Brazilian National Survey on Child Nutrition (ENANI-2019), which collected information from 14,558 children < 5 years old between February 2019 and March 2020. The present study included data from 5,831 biological mothers who reported having breastfed their child < 2 years old at least once and replied questions about cross-breastfeeding, donation and recaption of human milk to human milk banks. Prevalence and 95% confidence intervals (95%CI) were estimated for each stratifier, considering the study complex sample design. Among mothers of children < 2 years old who breastfed their child at least once, 21.1% practiced cross-breastfeeding; breastfeeding another child was more frequent (15.6%) than allowing a child to be breastfed by another woman (11.2%). Among this population, 4.8% of women donated human milk to a human milk bank, and 3.6% reported that their children had received donated human milk. The donation of human milk is a practice recommended by the Brazilian Ministry of Health and has the potential to save thousands of newborns throughout Brazil. In contrast, cross-breastfeeding is contraindicated due to the potential risk of transmitting HIV. There is a need for a broad debate on these practices in Brazil and worldwide.

https://doi.org/10.1590/0102-311xen082322

15.

Factors associated with anemia and vitamin A deficiency in Brazilian children under 5 years old: Brazilian National Survey on Child Nutrition (ENANI-2019)
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Castro, Inês Rugani Ribeiro de

; Normando, Paula

; Farias, Dayana Rodrigues

; Berti, Talita Lelis

; Schincaglia, Raquel Machado

; Andrade, Pedro Gomes

; Bertoni, Neilane

; Lacerda, Elisa Maria de Aquino

; Anjos, Luiz Antonio dos

; Boccolini, Cristiano Siqueira

; Reis, Marta Citelli dos

; Bezerra, Flávia Fioruci

; Pedrosa, Lucia Fatima Campos

; Jordão Junior, Alceu Afonso

; Lira, Pedro Israel Cabral de

; Kac, Gilberto

; Vertulli Carneiro, Letícia B.

; Alves-Santos, Nadya Helena

Cadernos de Saúde Pública

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2023, Volume 39 Suppl. 2 elocation e00194922

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: Fatores associados a anemia e deficiência de vitamina A foram investigados em 7.716 crianças de 6-59 meses de idade parte da Estudo Nacional de Alimentação e Nutrição Infantil (ENANI-2019). Adotamos uma abordagem hierárquica baseada em um modelo teórico do Fundo das Nações Unidas para a Infância (UNICEF) com três níveis estratificados por idade (6-23; 24-59 meses). Foram estimadas razões de prevalência (RP) e intervalos de 95% de confiança (IC95%). Determinantes habilitadores: observamos maior prevalência de anemia em crianças de 6-23 meses de idade cujas mães tinham ≤ 7 anos de escolaridade (RP = 1,92; IC95%: 1,10; 3,34), < 20 anos de idade (RP = 2,47; IC95%: 1,34; 4,56) ou 20-30 anos de idade (RP = 1,95; IC95%: 1,11; 3,44), cor parda (RP = 1,57; IC95%: 1,06; 2,23); e em crianças de 24-59 meses de idade na Região Norte (RP = 3,11; IC95%: 1,58; 6,13). Encontramos maior prevalência de deficiência de vitamina A em crianças de 6-23 meses de idade no Centro-oeste (RP = 2,32; IC95%: 1,33; 4,05) e em crianças de 24-59 meses de idade residentes nas regiões Norte (RP = 1,96; IC95%: 1,16; 3,30), Sul (RP = 3,07; IC95%: 1,89; 5,01) e Centro-oeste (RP = 1,91; IC95%: 1,12; 3,25) cujas mães tinham entre 20-34 anos de idade (RP = 1,62; IC95%: 1,11; 2,35). Determinantes subjacentes: a presença de mais de uma criança < 5 anos de idade no domicílio se associou a maior prevalência de anemia (RP = 1,61; IC95%: 1,15; 2,25) e deficiência de vitamina A (RP = 1,82; IC95%: 1,09; 3,05) em crianças de 6-23 meses de idade. Determinantes imediatos: o consumo de 1-2 grupos de alimentos ultraprocessados em crianças de 24-59 meses de idade (RP = 0,44; IC95%: 0,25; 0,81) e o não aleitamento materno no dia anterior em crianças de 6-23 meses de idade (RP = 0,56; IC95%: 0,36; 0,95) foram associados com a menor prevalência de anemia e deficiência de vitamina A. Políticas públicas focadas em grupos geográfica e socialmente vulneráveis são necessárias para promover equidade.

resumen está disponible en el texto completo

Abstract: Factors associated with anemia and vitamin A deficiency were investigated in 7,716 children 6-59 months of age studied in the Brazilian National Survey on Child Nutrition (ENANI-2019). We adopted a hierarchical approach based on a United Nations Children’s Fund (UNICEF) theoretical model with three levels, stratifying by age (6-23; 24-59 months). Prevalence ratio (PR) and 95% confidence interval (95%CI) were estimated. Enabling determinants: a higher prevalence of anemia was observed in children 6-23 months whose mothers had ≤ 7 years of schooling (PR = 1.92; 95%CI: 1.10; 3.34), < 20 years old (PR = 2.47; 95%CI: 1.34; 4.56) or 20-30 years old (PR = 1.95; 95%CI: 1.11; 3.44), mixed-race (PR = 1.57; 95%CI: 1.06; 2.23); and in children 24-59 months in the North Region (PR = 3.11; 95%CI: 1.58; 6.13). A higher prevalence for vitamin A deficiency was observed in children 6-23 months from Central-West (PR = 2.32; 95%CI: 1.33; 4.05), and in children 24-59 months living in the North (PR = 1.96; 95%CI: 1.16; 3.30), South (PR = 3.07; 95%CI: 1.89; 5.01), and Central-West (PR = 1.91; 95%CI: 1.12; 3.25) and whose mothers were 20-34 years (PR = 1.62; 95%CI: 1.11; 2.35). Underlying determinants: the presence of more than one child < 5 years old in the household was associated with a higher prevalence of anemia (PR = 1.61; 95%CI: 1.15; 2.25) and vitamin A deficiency (PR = 1.82; 95%CI: 1.09; 3.05) in children 6-23 months. Immediate determinants: consumption of 1-2 groups of ultra-processed foods in children 24-59 months (PR = 0.44; 95%CI: 0.25; 0.81) and lack of breastfeeding in the day before in children 6-23 months (PR = 0.56; 95%CI: 0.36; 0.95) were associated with lower prevalence of anemia and vitamin A deficiency. Public policies focused on geographically and socially vulnerable groups are needed to promote equity.

https://doi.org/10.1590/0102-311xen194922

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