ABSTRACT The use of biochar (BC) seems to be a promising alternative for efficient and environmentally friendly waste management that could help to promote cleaner agricultural production. The objective of this research was to evaluate the aromatic profile of coffee (Coffea arabica L.) beans and cup quality parameters in response to the application of four different doses of biochar (0, 4, 8, and 16 t ha-1) obtained from coffee pulp, and four levels of chemical fertilization (CF) (0%, 33%, 66% and 100% of nutritional requirements). An electronic nose was used to analyze volatile compounds and their relationship with coffee quality parameters: Soluble solids (TSS), pH, titratable acidity. Applications of 8 and 16 t ha-1 BC and 66% and 100% CF registered greater sensitivity to the aromatic compounds of roasted coffee beans in sensors W1C, W3C, and W5C. The BC amendments between 8 and 16 t ha-1 and CF 66% and 100% increased the TSS content (CF 66%: 1.32 °Brix and CF 100%: 1.38 °Brix), reduced the pH (CF 66%: 4.95 and CF 100%: 4.88) and increased titratable acidity (CF 66%: 697.88 mg CaCO3 L-1 and CF 100%: 662.56 mg CaCO3 L-1) in beverages of ‘Castillo El Tambo’ coffee bean in the year 2020. Finally, the co-application of BC as a complement to CF showed a positive effect on the aromatic profile. This methodology could be an original approach to characterize beans according to the coffee crop’s nutritional status, helping in factors focused on quality and traceability.

SUMMARY Objective: To establish the infections associated with health care in surgically treated patients, without considering operative site (ISO) infections. Materials and methods: A search of the literature was performed in MEDLINE, CENTRAL, LILACS databases in addition to unpublished literature, identifying studies related to infections associated with health care in adult patients who underwent surgery. Results: In the search performed, 25 articles were selected, from which the results were extracted. The most frequent IAAS in the studies reviewed were: ventilator-associated pneumonia (36%), pneumonia associated with health care (32%), urinary tract infections by urinary catheter (48%), infections associated with venous catheter (8 %). Conclusion: Infections associated with health care in patients brought to surgical procedures, most frequently found are ventilator-associated pneumonia, pneumonia associated with health care, urinary tract infection by catheter and venous catheter-associated infections. However, they continue to generate questions, since ISO is the most documented, suggesting more studies and research.

RESUMEN Objetivo: Establecer las infecciones asociadas a la atención de la salud en pacientes intervenidos quirúrgicamente, sin tener en cuenta las infecciones del sitio operatorio (ISO). Materiales y métodos: Se realizó una búsqueda de la literatura en las bases de datos de MEDLINE, CENTRAL, LILACS además de la literatura gris, para identificar estudios relacionados con infecciones asociadas a la atención de la salud en pacientes adultos que fueron intervenidos quirúrgicamente. Resultados: En la búsqueda realizada se seleccionaron 25 artículos de los cuales se extrajeron los resultados. Las IAAS más frecuentes en los estudios revisados fueron: neumonía asociada al ventilador (36%), neumonía asociada al cuidado de la salud (32%), infecciones de tracto urinario por catéter urinario (48%), infecciones asociadas a catéter venoso (8%). Conclusión: Las infecciones asociadas a la atención de la salud frecuentemente encontradas en pacientes llevados a procedimientos quirúrgicos son la neumonía asociada al ventilador, neumonía asociada al cuidado de la salud, la infección del tracto urinario por catéter y las infecciones asociadas a catéter venoso, sin embargo, las infecciones de sitio operatorio (ISO) son las más documentadas, situación que requiere mayor atención y abordaje a través de otros estudios de investigación.

ABSTRACT The fertilizers costs are currently elevated, and it is necessary to evaluate complementary agronomic strategies. Biochar (BC) offers several potential benefits at a relatively low cost. The research aimed was to study the effect of the application of four different doses of biochar (BC) (0, 4, 8, and 16 t ha-1) and four fertilization levels (FL) (0%, 33%, 66% and 100% of the nutritional requirements). We obtained the BC from coffee (Coffea arabica L.) pulp. The selected response variables were: Stomatal conductance (gs), water use efficiency (WUE), root hydraulic conductivity (K), leaf photosynthetic pigments (Chl), and total dry weight (TDW) of coffee ‘Castillo el Tambo’. The experiment was conducted under greenhouse conditions. The results showed that plants with 0 t ha-1 and 0% FL registered low values in the physiological parameters evaluated (gs = 60.5 mmol m-2 s-1; WUE = 3.03 g DM L-1 H2O; Chl = 59.4 atLEAF readings; Kr = 9.7×10-6 kg s-1 MPa-1; TDW = 9.7 g). On the other hand, we recorded a positive effect when ‘Castillo el Tambo’ coffee plants received 8 t ha-1 BC (Kr = 11.8×10-6 kg s-1 MPa-1), especially at fertilization levels of 66% and 100% (gs = 146.7 and 167.5 mmol m-2 s-1; Chl = 72.8 and 66.6 Chl content; WUE = 4.3 and 5.0 g DM L-1 H2O; TDW = 13.6 and 16.0 g, respectively). In conclusion, the use of BC manufactured with coffee pulp, mainly at a dose of 8 t ha-1, can be an alternative to complement the chemical nutrition of coffee plants.

ABSTRACT Introduction: The relationship between ADHD and epilepsy, although very frequent, is not clear. Clinical studies in neuropsychology and neurology (neuropsychiatry) can provide valuable information for assessment, intervention and treatment. Method: A non-experimental design, quantitative approach, descriptive level and cross-sectional study was carried out with the aim of comparing the executive functioning of a group of children with ADHD and a group of children with ADHD and CPSDD. A convenience sample of 40 matched children (all males) grouped in two groups of 20 children between 7 and 13 years of age was formed. In order to evaluate executive functioning, some tests of the Neuropsychological Battery of Executive Functions and Frontal Lobes - BANFE were applied. Results: According to the bilateral asymptotic significance values, statistically significant differences were found in the variables Stroop A - Hits, Stroop B - Hits, Self-directed Signaling (Hits, Planning and Time), and Visuospatial Working Memory (Maximum Level, Perseverations and Order Errors). Conclusions: The results of the present study coincide with the failures in inhibitory control and sustained attention problems reported in the literature. Children with EBPCT and ADHD have a different and more impaired executive functioning profile than children with ADHD alone.

RESUMEN Introducción: La relación entre el TDAH y la epilepsia, aunque muy frecuente, no es clara. Los estudios clínicos en neuropsicología y neurología (neuropsiquiatría) pueden ofrecer información valiosa para la evaluación, la intervención y el tratamiento. Método: Se realizó un estudio con diseño no experimental, enfoque cuantitativo, nivel descriptivo y corte transversal con el objetivo de comparar el funcionamiento ejecutivo de un grupo de niños con TDAH y un grupo de niños con TDHA y EBPCT. Se conformó una muestra por conveniencia de 40 niños emparejados (todos hombres) agrupados en dos grupos de 20 con edades entre los 7 y los 13 años. Para realizar la evaluación del funcionamiento ejecutivo se aplicaron algunas pruebas de la Batería Neuropsicológica de Funciones Ejecutivas y Lóbulos Frontales – BANFE. Resultados: De acuerdo con los valores de la significancia asintótica bilateral, se encontraron diferencias estadísticamente significativas en las variables Stroop A – Aciertos, Stroop B – Aciertos, Señalamiento autodirigido (Aciertos, Planeación y Tiempo), y Memoria de Trabajo Visoespacial (Nivel máximo, Perseveraciones y Errores de orden). Conclusiones: Los resultados del presente estudio coinciden con los fallos en el control inhibitorio y los problemas de atención sostenida reportados en la literatura. Los niños con EBPCT y TDAH tienen un perfil de funcionamiento ejecutivo diferente y más deteriorado que los niños con TDAH solo.

Abstract: The question about how the early development of shared intentionality occurs has been generating multiple investigations in developmental psychology. This paper puts a conceptual analysis of this topic forward through a systematic review methodology; empirical studies published between 2005 and 2020 in Ebsco, Science Direct, Dialnet, Scielo, Jstor and Scopus were taken into account. We found 73 papers about shared intentionality development that can be framed into two accounts: Contemporary neonativism and development science. These accounts have different perspectives about the following subjects related with shared intentionality development: (1) the importance of experience and innate mechanisms; (2) the differentiation between acquisition and development; (3) the role of behavior according to the context and (4) the need to understand processes of change. The paper analyzes the implications of these differences and the limitations of this categorization.

Resumen: La pregunta de cómo sucede el desarrollo temprano de la intencionalidad compartida viene generando múltiples investigaciones en la psicología del desarrollo. El presente artículo se centra en el análisis conceptual del tema siguiendo la metodología de una revisión sistemática; se retomaron trabajos de carácter empírico publicados entre 2005 y 2020 y que fueron publicados en las bases de datos Ebsco, Science Direct, Dialnet, Scielo, Jstor y Scopus. Se encontraron 73 estudios sobre el desarrollo de la intencionalidad compartida que pueden enmarcarse en dos posturas: El neonativismo contemporáneo y la ciencia del desarrollo. Dichas posturas comprenden de manera distinta los siguientes aspectos del desarrollo de la intencionalidad compartida: ( ) la importancia de la experiencia y de los mecanismos innatos; (2) la diferenciación entre adquisición y desarrollo; (3) la función de la conducta de acuerdo con el contexto; y (4) la necesidad de comprender los procesos de cambio. El artículo analiza las implicaciones de estas diferencias.

ABSTRACT Fused deposition modeling (FDM) has gained popularity recently due to its versatility and low cost. Considering that the quality of printed parts depends on many variables, a 3^3 factorial design of experiments was conducted, where three influential parameters in the process were studied: layer height (0.15, 0.2, and 0.25 mm), infill percentage (30%, 60%, and 90%), and shell count (2, 3, and 4), using polylactic acid as the material. Their effects on tensile strength, flexural strength, printing time, and interactions were measured. The maximum tensile and flexural stress obtained were 33.5 MPa and 87.3 MPa, respectively, at a 90% infill percentage. It was found that layer height does not significantly affect mechanical strength, while infill percentage has the most significant influence, followed by the number of shells. The latter two factors show a meaningful interaction. Furthermore, all the studied parameters have a significant impact on printing time.

Resumen La vena cava superior izquierda persistente es la anomalía venosa más frecuente en el drenaje sistémico en adultos; tiende a ser asintomática, pero causa trastornos del ritmo como taquiarritmias o bradiarritmias. Se presenta un caso de vena cava superior izquierda persistente diagnosticada en una paciente de 53 años hospitalizada por un síndrome coronario agudo asociado a bradicardia inestable. Un marcapasos transvenoso dejó una impresión en la aurícula izquierda, por lo que se requirió un ecocardiograma transtorácico para diagnosticar la vena cava superior izquierda persistente. La paciente necesitó una intervención percutánea con una adecuada evolución y se le dio el alta de la unidad de cuidados intensivos.

Abstract The persistent left superior vena cava is the most common venous anomaly in the systemic drainage in adults and tends to be asymptomatic. The persistent left superior vena cava causes rhythm disorders such as tachyarrhythmias or bradyarrhythmias. We report a case of persistent left superior vena cava diagnosed in a 53-year-old female patient admitted due to an acute coronary syndrome associated with unstable bradycardia. A transvenous peacemaker impressed the left atrium; therefore, a transthoracic echocardiogram was required to diagnose persistent left superior vena cava. The patient needed management with percutaneous intervention; she had an adequate evolution and subsequent discharge from the intensive care unit

Abstract The methodological moments of a state of the art on mental health in the indigenous peoples of Colombia are presented, with the purpose of making a contribution in the foundation of new research and the development of intervention strategies based on documentary evidence. Also, it reflects on the need to have the perspective and participation of indigenous researchers in these studies and the importance of incorporating the knowledge of Indigenous Peoples is recognized for the correct conceptualization of the phenomenon under study as mental health. The challenges and limitations of this research are presented and it is suggested that the approach and procedure described may be useful in other studies related to indigenous communities.

Resumen Se presentan los momentos metodológicos de un estado del arte sobre la salud mental en los pueblos indígenas de Colombia, con el propósito de realizar un aporte en la fundamentación de nuevas investigaciones y el desarrollo de estrategias de intervención basadas en la evidencia documental. También, se reflexiona sobre la necesidad de contar con la perspectiva y la participación de investigadores indígenas en estos estudios y se reconoce la importancia de incorporar los saberes de los pueblos indígenas para la conceptualización acertada del fenómeno de estudio como la salud mental. Se presentan los retos y limitaciones de esta investigación y se sugiere que el enfoque y el procedimiento descritos pueden ser de utilidad en otros estudios relacionados con comunidades indígenas.

Resumen Introducción: los cuidados paliativos han estado ligados al manejo de pacientes sin opción curativa. La detección de la desnutrición permite establecer estrategias de intervención nutricional que promueven el adecuado uso de los recursos y aportan a las medidas de apoyo en el tratamiento médico. Objetivo: describir los cambios en el estado nutricional y su impacto sobre la supervivencia en pacientes con enfermedad oncológica bajo cuidado paliativo. Métodos: cohorte observacional retrospectiva. Los pacientes presentaban enfermedad oncológica en estadio IV, índice de Karnofsky ≤ 70 y un pronóstico de supervivencia < 6 meses. Se realizó una evaluación nutricional por los criterios GLIM, con seguimiento por un año. Se identificó el estado nutricional y se describieron sus características, la presencia de los estadios de caquexia y la mediana de supervivencia a un año. Resultados: de 256 pacientes al inicio de la intervención, el 84,0 % presentaban algún grado de desnutrición, cifra que se incrementó al 87,0 % al finalizar el seguimiento. Se observó un aumento en el número de pacientes con índice de masa corporal (IMC) delgado (+7,6 %, p = 0,04) y una disminución en el número de pacientes con exceso de peso (sobrepeso: -3,6 %, p = 0,24; y obesidad: -2,6 %, p = 0,17). La supervivencia global a 1 año fue del 60 % (IC 95 %: 53-66). Conclusión: la desnutrición fue frecuente en pacientes bajo cuidado paliativo y aumentó a lo largo del seguimiento. Se observaron diferencias entre el diagnóstico nutricional y el IMC, lo cual puede llevar a una mala clasificación del diagnóstico y a una disminución en la efectividad del tratamiento oncológico.

Abstract Introduction: palliative care has been linked to the management of patients without a curative option. The detection of malnutrition allows establishing nutritional intervention strategies to make an adequate use of resources and contribute to support measures. Objective: to describe changes in nutritional status and their impact on survival in patients with cancer disease under palliative care. Methods: a descriptive observational study of a retrospective cohort. The patients had stage IV cancer disease, Karnofsky index ≤ 70 and a survival prognosis < 6 months. A complete nutritional assessment was carried out and they were followed for one year. Nutritional status and its characteristics, presence of cachexia, and median survival at one year were described. Results: of 256 patients at the beginning of follow-up, 60.9 % had some degree of malnutrition, which increased to 71.9 % at the end of follow-up. There was an increase in patients with a thin body mass index (BMI) (+7.6 %, p = 0.04) and a decrease in patients with excess weight (overweight: -3.6 %, p = 0.24; and obesity: -2.6 %, p = 0.17). Overall survival at 1 year was 60 % (95 % CI: 53-65). Conclusion: malnutrition was frequent in patients under palliative care (60.9 %) and increased throughout follow-up. Differences were observed between the complete nutritional diagnosis and BMI, which can lead to a misclassification of the diagnosis and a decrease in the effectiveness of cancer treatment.

RESUMEN Introducción. Las lesiones del tracto urinario son frecuentes en el contexto de la cirugía pélvica; sin embargo, existe poca información sobre su manejo por vía laparoscópica. Se presenta el caso de una paciente con una lesión vesical intraperitoneal secundaria a cirugía pélvica ginecológica, quien recibió manejo por abordaje laparoscópico, y se propone un algoritmo de tratamiento. Presentación del caso. Mujer de 39 años quién, luego de tres días de practicársele una salpingectomía izquierda y una resección del dispositivo intrauterino migrado mediante abordaje laparoscópico, consultó al servicio de urgencias por dolor abdominal generalizado y oligoanuria. Los exámenes de laboratorio evidenciaron microhematuria, creatinina sérica de 4.35mg/dl y nitrógeno ureico de 35,2mg/dl. En cistografía por tomografía computarizada (cisto-TC) se observó una solución de continuidad de la pared vesical posterolateral izquierda intraperitoneal. A la paciente se le trató la lesión vesical de forma exitosa por vía laparoscópica, y dos semanas después, también mediante cistografía retrógrada se confirmó una adecuada resolución de la misma. Conclusión. Dados los resultados satisfactorios del manejo laparoscópico en la paciente y los beneficios de esta técnica, se puede concluir que el abordaje laparoscópico de las lesiones quirúrgicas de la vejiga es una opción terapéutica factible.

ABSTRACT Introduction: Urinary tract injuries are common in the context of pelvic surgery; however, there is little information in the medical literature on the management of these injuries using a laparoscopic approach. The following is the clinical case of a patient with intraperitoneal bladder injury secondary to gynecological pelvic surgery that was successfully treated using a laparoscopic approach. Moreover, a management algorithm is proposed based on the scientific data available. Case report. A 39-year-old female patient was admitted to the hospital with generalized abdominal pain and anuria three days after undergoing a left laparoscopic salpingectomy and resection of a migrated intrauterine device. Laboratory tests showed microhematuria, serum creatinine of 4.35mg/dL, and urea nitrogen of 35.2mg/dL. Computed tomography cystography showed a solution of continuity on the left posterolateral intraperitoneal bladder. The patient underwent successful laparoscopic treatment for the bladder injury, and two weeks later, retrograde cystography confirmed its adequate resolution. Conclusions. Based on the benefits of the laparoscopic approach and after extrapolating the outcomes of the laparoscopic management of bladder trauma, it can be concluded that the laparoscopic approach to surgical injuries of the bladder is a feasible therapeutic option.

RESUMEN Introducción. El adenoma metanéfrico es un tumor renal benigno poco frecuente. Los pacientes con estos tumores no suelen presentar síntomas, aunque en el 12% de los casos se presenta policitemia. En las imágenes diagnósticas, los adenomas metanéfricos se observan como lesiones sólidas, únicas y bien definidas que, por lo general, comprometen la medula renal pero no ocasionan compromiso extrarenal. Estas neoplasias son difíciles de diferenciar imagenológicamente de neoplasias malignas del tracto urinario superior, por lo que el diagnóstico definitivo se logra mediante estudios histopatológicos. El tratamiento de elección es la nefrectomía radical. Presentación del caso. Mujer de 51 años procedente de Bogotá (Colombia), quien fue remitida al servicio de urología de un hospital de tercer nivel de atención por dolor lumbar bilateral de características inespecíficas. Al momento de la consulta la paciente se encontraba asintomática. Mediante ecografía renal y de vías urinarias se evidenció hidronefrosis y una masa renal derecha. Se ordenó urografía por tomografía axial computarizada que documentó una lesión en la pelvis renal derecha con invasión al parénquima renal altamente sugestiva de carcinoma urotelial de tracto urinario superior de alto riesgo, así como adenopatías en los ganglios paraaórticos, por lo que se le realizó una nefroureterectomía radical derecha con cuña vesical que permitió establecer un diagnóstico final de adenoma metanéfrico según el estudio histopatoló-gico. La paciente tuvo una evolución satisfactoria. Conclusiones. El adenoma metanéfrico es un tumor poco frecuente y de difícil diagnóstico imagenológico, por lo que se requiere explorar herramientas adicionales para establecer un diagnóstico certero prequirúrgico que permita preservar la unidad renal afectada. Asimismo, dada su inespecificidad, estos tumores deben incluirse dentro de los diagnósticos diferenciales de las lesiones sugestivas de carcinoma urotelial de tracto urinario superior.

ABSTRACT Introduction: Metanephric adenoma is a rare benign kidney tumor. Patients with these tumors are usually asymptomatic, although polycythemia occurs in up 12% of cases. These masses are often described on diagnostic imaging as solid, single, well-defined, oval-shaped, unilateral lesions, located primarily in the renal medulla and without extrarenal involvement. These neoplasms are difficult to differentiate from malignant neoplasms of the upper urinary tract, so the definitive diagnosis is achieved by histopathology. Currently, the treatment of choice is radical nephrectomy. Case presentation: A 51-year-old woman from Bogotá (Colombia) was referred to the urology service of a tertiary care hospital due to bilateral lumbar pain of non-specific characteristics. At the time of consultation, the patient was asymptomatic. Renal and urinary tract ultrasound showed hydronephrosis and right renal mass. Computed tomography urography was requested, which revealed a lesion in the right renal pelvis with parenchymal invasion highly suggestive of high-risk upper urinary tract urothelial carcinoma, as well as adenopathies in the para-aortic lymph nodes. The patient underwent a radical nephroureterectomy with bladder cuff, which allowed establishing a final diagnosis of metanephric adenoma according to the histopathological study. Conclusions: Metanephric adenoma is a rare tumor that is difficult to diagnose through imaging, so it is necessary to explore additional tools to establish an accurate pre-surgical diagnosis that allows preserving the affected renal unit. Also, given their non-specificity, these tumors should be included in the differential diagnosis of lesions suggestive of upper tract urothelial carcinoma.

Resumen Objetivo: determinar los desenlaces renales de los pacientes con requerimiento de diálisis por lesión renal aguda, que ingresaron a la unidad de cuidado intensivo del Hospital Departamental Universitario Santa Sofía de Caldas desde el año 2006 a 2018 y determinar los factores asociados a estos desenlaces. Métodos: estudio retrospectivo de cohortes llevado a cabo en el Hospital Departamental Universitario Santa Sofía de Caldas en 122 pacientes mayores de 18 años, que requirieron diálisis por lesión renal aguda en la unidad de cuidado intensivo entre los años 2006 y 2018. Se evaluó el desenlace compuesto del MAKE (Major Adverse Kidney Events) conformado por recuperación parcial de la función renal, dependencia de la diálisis y muerte con seguimiento a los 90 días y un año. Resultados: existe asociación entre diabetes, puntaje APACHE II, acidosis metabólica, anuria y tiempo de inicio de la diálisis con el MAKE a 90 días y al año. En la regresión logística aquellos pacientes que desarrollaron MAKE a los 90 días tenían mayor probabilidad de haber presentado anuria (OR=6.71; IC95%: 1497-30 076), acidosis (OR=4349; IC95%: 1616-11.7) e inicio tardío de la terapia (OR=3013; IC95%: 1241-7316). En el MAKE a un año hubo resultados similares, adicionando modalidad de terapia continua (OR=2841; IC95%: 1193-6763). Conclusiones: diabetes, APACHE II alto, anuria, acidosis metabólica y terapia dialítica tardía son más frecuentes en pacientes que desarrollan MAKE. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2229).

Abstract Objective: to establish the renal outcomes of patients needing dialysis due to acute kidney injury who were admitted to the intensive care unit at Hospital Departamental Universitario Santa Sofía de Caldas from 2006 to 2018, and determine the factors associated with these outcomes. Methods: a retrospective cohort study carried out at Hospital Departamental Universitario Santa Sofía de Caldas on 122 patients over the age of 18 who required dialysis in the intensive care unit due to acute kidney injury, from 2006 to 2018. The major adverse kidney events (MAKE) composite outcome was evaluated, composed of partial recovery of kidney function, dialysis dependence and death, with 90-day and one-year follow up. Results: there is a relationship between diabetes, the APACHE II score, metabolic acidosis, anuria and the dialysis start time and MAKE at 90 days and one year. In the logistic regression, patients who developed MAKE at 90 days had a greater probability of having had anuria (OR=6.71; 95%CI: 1,497-30,076), acidosis (OR=4,349; 95%CI: 1,616-11.7) and a late treatment start (OR=3,013; 95%CI: 1,241-7,316). The one-year MAKE showed similar results, with the addition of the continu ous therapy modality (OR=2,841; 95%CI: 1,193-6,763). Conclusions: diabetes, a high APACHE II, anuria, metabolic acidosis and late dialysis treat ment are more frequent in patients who develop MAKE. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2229).

Objective: To improve the ability of psychiatry researchers to build, deploy, maintain, reproduce, and share their own psychophysiological tasks. Psychophysiological tasks are a useful tool for studying human behavior driven by mental processes such as cognitive control, reward evaluation, and learning. Neural mechanisms during behavioral tasks are often studied via simultaneous electrophysiological recordings. Popular online platforms such as Amazon Mechanical Turk (MTurk) and Prolific enable deployment of tasks to numerous participants simultaneously. However, there is currently no task-creation framework available for flexibly deploying tasks both online and during simultaneous electrophysiology. Methods: We developed a task creation template, termed Honeycomb, that standardizes best practices for building jsPsych-based tasks. Honeycomb offers continuous deployment configurations for seamless transition between use in research settings and at home. Further, we have curated a public library, termed BeeHive, of ready-to-use tasks. Results: We demonstrate the benefits of using Honeycomb tasks with a participant in an ongoing study of deep brain stimulation for obsessive compulsive disorder, who completed repeated tasks both in the clinic and at home. Conclusion: Honeycomb enables researchers to deploy tasks online, in clinic, and at home in more ecologically valid environments and during concurrent electrophysiology.

Resumo O objetivo deste trabalho foi avaliar a atividade quitinolítica e a bioatividade de fungos isolados do gorgulho-da-palmeira (Rhynchophorus palmarum) e de amostras de solos de áreas de cultivo de coco (Cocos nucifera) contra o próprio inseto. Inicialmente, para determinar as propriedades quitinolíticas dos fungos isolados, foi avaliada a sua capacidade de hidrolisar quitina em meio de cultura líquido. Em seguida, foram realizados ensaios preliminares de patogenicidade, tendo-se utilizado o gorgulho-do-feijão (Acanthoscelides obtectus) como modelo, para selecionar os isolados fúngicos a serem usados nos experimentos com o gorgulho-da-palmeira. Por fim, avaliou-se a bioatividade de dois fungos entomopatogênicos selecionados em larvas e adultos do gorgulho-da-palmeira. Não houve correlação direta entre a atividade quitinolítica e a capacidade de patogenicidade sobre o gorgulho-do-feijão nem entre os isolados e a bioatividade sobre o gorgulho-da-palmeira. Beauveria bassiana CSU9 apresenta a maior atividade sobre larvas e adultos do gorgulho-da-palmeira, com tempo letal médio de 0,8 e 14,4 dias, respectivamente.

Abstract The objective of this work was to evaluate the chitinolytic activity and bioactivity of fungi isolated from the palm weevil (Rhynchophorus palmarum) and from soil samples from coconut (Cocos nucifera) crops against the insect itself. Initially, to determine the chitinolytic properties of the isolated fungi, their ability to hydrolyze chitin in a liquid culture medium was evaluated. Then, preliminary pathogenicity assays were carried out, using the bean weevil (Acanthoscelides obtectus) as a reference, to select the fungal isolates to be used in the experiments with the palm weevil. Fi n a l ly, the bioactivity of two selected entomopathogenic fungi on palm weevil larvae and adults was assessed. There was no direct correlation between chitinolytic activity and pathogenicity capacity on the bean weevil nor between the isolates and bioactivity on the palm weevil. Beauveria bassiana CSU9 shows the highest activity on palm weevil larvae and adults, with a median lethal time of 0.8 and 14.4 days, respectively.

Abstract Introduction: Congenital heart diseases are the most common congenital abnormalities in newborns with a prevalence of 1%. Therapeutic and diagnostic cardiac catheterization has revolutionized the treatment of these diseases; however, it can be associated with complications. Objective: To describe the incidence and type of complications associated with pediatric cardiac catheterization in a reference center for congenital heart defects. Methodology: Retrospective observational study, with analytical intention based on records of cardiac catheterization performed on patients with congenital and acquired heart disease. Results: 2,688 records were included for nine consecutive years. 53.9% were men, 21.3% with ages between 2 and 5 years and 20.3% between 6 months and 2 years. 63.5% of the procedures were elective. The prevalence of complications in the first 24 hours after catheterization was 6.7% (4.2% minor and 2.4% major). Early death occurred in 0.8% of the procedures. Factors associated with complications were age at catheterization <28 days (OR 2.18, 95% CI [1.28-3.70]), precatheter oxygen saturation <79% (OR 2.15, 95% CI [1.02-4.53]), use of pre-catheter inotropics (OR 3.00, 95% CI [1.68-5.33]). The variables included in the model explain 38% of the variance of post-cardiac catheterization complications in patients younger than 18 years. Discussion: Cardiac catheterization is associated with major and minor complications including death. The associated factors were less than 28 days, lower oxygen saturation and use of pre-catheter inotropics.

Resumen Introducción: Las cardiopatías congénitas son las anomalías congénitas más comunes en recién nacidos con una prevalencia de 1%. El cateterismo cardíaco diagnóstico y terapéutico ha revolucionado el tratamiento de estas enfermedades, aunque puede acompañarse de complicaciones. Objetivo: Describir la incidencia y el tipo de complicaciones vinculadas con el cateterismo cardíaco pediátrico en un centro de referencia para cardiopatías congénitas. Método: Estudio observacional retrospectivo, con intención analítica a partir de registros de cateterismos cardíacos realizados a pacientes con cardiopatías congénitas y adquiridas. Resultados: Se incluyeron 2,688 registros durante nueve años consecutivos. El 53.9% correspondió a hombres, 21.3% con edades de dos a cinco años y 20.3% de seis meses a dos años. El 63.5% de los procedimientos fue electivo. La prevalencia de complicaciones en las primeras 24 horas posteriores al cateterismo fue de 6.7% (4.2% menores y 2.4% mayores). En el 0.8% de los procedimientos sobrevino la muerte temprana. Los factores relacionados con las complicaciones fueron: edad al momento del cateterismo <28 días (OR, 2.18; IC 95%, 1.28-3.70), saturación de oxígeno antes del cateterismo <79% (OR, 2.15; IC 95%, 1.02-4.53), uso de inotrópicos antes del cateterismo (OR, 3.00; IC 95%, 1.68-5.33). Las variables incluidas en el modelo explican el 38% de la varianza de las complicaciones posteriores al cateterismo cardíaco en pacientes menores de 18 años. Conclusiones: En este estudio, el cateterismo cardíaco se vinculó con complicaciones mayores y menores, incluida la muerte. Los factores adjuntos fueron edad menor de 28 días, menor saturación de oxígeno y uso de inotrópicos antes del cateterismo.