Abstract INTRODUCTION In leprosy, immune system mediators that regulate the infectious process act in a complex manner and can lead to several clinical outcomes. To understand the behavior of these mediators we quantified the expression of annexin-A1 (ANXA1) in the peripheral blood and plasma as well as tissue leukocytes in all clinical forms of leprosy and compared with healthy controls. METHODS Seventy healthy controls and 70 patients with leprosy, tuberculoid (TT) (n = 13), borderline tuberculoid (BT) (n = 15), borderline borderline (BB) (n = 13), borderline lepromatous (BL) (n = 15), and lepromatous leprosy (LL) (n = 14), were selected. Phenotyping of the lymphocyte cells and the intracellular expression of ANXA1 in leukocytes was performed by immunofluorescence. Plasma protein levels were determined by enzyme-linked immunosorbent assay. RESULTS Histiocytes and CD4+ and CD8+ T cells in the skin of BL and LL patients had higher ANXA1 expression. ANXA1 expression was also high in circulating polymorphonuclear, monocytes, and CD4+ and CD8+ T cells in the blood of LL patients compared to those of TT, BT, BB, and BL patients, and these levels were similar to those in healthy controls. Plasma ANXA1 levels indicate an increase in paracrine release in patients with LL. CONCLUSIONS The data indicate that ANXA1 expression is enhanced in the leukocytes and plasma of patients with LL, and may contribute to the inhibition of leukocyte action, leading to inadequate functioning of the immune system and thus contributing to the spread of M. leprae infection.

ABSTRACT Stem conicity and the sawing pattern, besides the presence of hollows and sapwood, are among the principal factors that are responsible for the low yield of lumber from harvested wood in the Amazon. Therefore, the objective of this study was to analyze of logs and stem conicity, and its effect on yield of sawn wood from the species Handroanthus impetiginosus (Mart. ex DC.) Mattos, Lecythis lurida (Miers) S. A. Mori, Manilkara huberi (Ducke) Chevalier, Astronium lecointei Ducke and Couratari sp., which are currently the most important commercial species in the study area. The data used were obtained from six production units in the Tapajós National Forest, Pará. The variables analyzed were conicity (obtained as a function of the difference between diameters at the base and top) between logs, DBH classes (diameter at breast height) and species, as well as yield (estimated using the Software MaxiTora) between logs and species. The majority of the species showed differences in conicity between logs, with the first log being the most conic, which was directly reflected by the lower yield for this log. There was a tendency of increase in conicity in the larger DBH classes, and differences in conicity and yield between species. The estimated yields were superior to the percent yields observed for Amazonian species in studies done using samples with similar characteristics. Therefore, it was concluded that conicity can vary between species, logs, and DBH classes, and is a characteristic that directly effects the yield of lumber. Furthermore, the incorporation of cutting templates represents an alternative for maximizing lumber yield.

Abstract INTRODUCTION: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. METHODS: Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. RESULTS: The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Significant differences were identified, which included hypochromic lesions predominantly in the BT clinical form (24%); diffuse-type lesions predominantly in the tuberculoid (TT) clinical form (28%); ill-defined lesion border dominance in lepromatous leprosy (LL) clinical forms (30%); an irregular lesion limit predominantly in LL clinical forms (32%); and a predominant Th1 immune response in the BT clinical form (41.7%). CONCLUSIONS: The evaluation of the immunological profile in leprosy patients may contribute to the more detailed diagnosis and possibly better characterization of the prognosis for these individuals.

The vallates papillae lingual are located in the surface of the tongue in a area denominated of V lingual and it presents cells gustatory gathered in gustatory buttons. This research evaluated the height papilar in relation to the surface of the tongue of 519 lingual vallates papillae. 45 human tongue samples were selected, of both sexes, inside of the 40-50 year-old age group, obtained from necropsias accomplished in the Service of Verification of Deaths (S.V.O.) of UFPE/Secretaria of Health of the state of Pernambuco, in the city of Recife. The samples were classified different height levels accordingly in relation to the surface of the tongue, not establishing the exact height, where there was the predominance of the height above the lingual surface

Las papilas valadas linguales están localizadas en la superficie dorsal de la lengua, en un área denominada V lingual y presentan células gustativas acumuladas en botones gustativos. Se evaluó la altura papilar en relación con la superficie de la lengua de 519 papilas valadas linguales. Fueron seleccionadas 45 lenguas humanas, de individuos de ambos sexos, de 45 a 50 años de edad, obtenidas de autopsias del Servicio de Verificación de Óbitos de la Universidade Federal ed Pernambuco /Secretaría de Salud del Estado de Pernambuco, Recife, Brasil. Las muestras fueron clasificadas de acuerdo a los niveles de altura en relación con la superficie de la lengua, no estableciéndose la altura exacta, donde hubo predominio de papilas ubicadas sobre la superficie lingual