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Abstract This study aimed to assess the impact of the implementation of a rapid multiplex molecular FilmArray Respiratory Panel (FRP) on the medical management of immunocompromised patients from a community general hospital. We conducted a single-center, retrospective, and before-after study. Two periods were evaluated: before the implementation of the FRP (pre-FRP) from April 2017 to May 2018 and after the implementation of the FRP (post-FRP) from January to July 2019. The inclusion criteria were immunocompromised patients over 18 years of age with suspected acute respiratory illness tested by conventional diagnostic meth-ods (pre-FRP) or the FilmArray™ Respiratory Panel v1.7 (post-FRP). A total of 142 patients were included, 64 patients in the pre-FRP and 78 patients in the post-FRP. The positive detec-tion rate was significantly higher in the post-FRP (63% vs. 10%, p <0.01). There were more patients receiving antimicrobial treatment in the pre-FRP compared with the post-FRP period (94% vs. 68%, p <0.01). A decrease in beta-lactam (89% vs. 61%, p <0.01) and macrolide (44% vs. 13%, p < 0.01) prescriptions were observed in the post-FRP. No differences were observed in oseltamivir use (22% vs. 13%, p = 0.14), changes in antimicrobial treatment, hospital admission rate, days-reduction in droplet isolation precautions, hospital length of stay (LOS), admission to intensive care unit (ICU), LOS in ICU, treatment failure and 30-day mortality. The implementa-tion of the FRP impacted patient care by improving diagnostic yield and optimizing antimicrobial treatment in immunocompromised adult patients.

Resumen El objetivo de este estudio fue evaluar el impacto de la implementación del panel respiratorio FilmArray® (FRP), un sistema automatizado de PCR multiplex, en el estándar de cuidado de pacientes adultos inmunocomprometidos en un hospital general. Es un estudio retrospectivo de un único centro con diseno antes/después. Los periodos evaluados fueron abril 2017-mayo 2018, previo a la implementación del FRP (pre-FRP), y enero 2019-julio 2019, luego de la implementación (post-FRP). Los criterios de inclusión fueron pacientes mayores de 18 años inmunocomprometidos con sospecha de infección respiratoria aguda a los que se les realizó, en pre-FRP, diagnóstico por métodos convencionales, y en post-FRP, el panel respiratorio FRP versión 1.7. Se incluyeron un total de 142 pacientes, 64 en pre-FRP y 78 en post-FRP. La tasa de positividad fue significativamente mayor en post-FRP frente a pre-FRP (63 vs. 10%, p<0,01). Hubo más pacientes con tratamiento antimicrobiano en pre-FRP que en post-FRP (94 vs. 68%, p <0,01). En pre-FRP hubo más pacientes tratados con betalactámicos (89 vs. 61%, p <0,01) y macrólidos (44 vs. 13%, p < 0,01). No se observaron diferencias significativas en el uso de oseltamivir (22 vs. 13%, p = 0,14), cambios en los tratamientos, número de hospitalizaciones, uso de aislamientos, duración de la estadía hospitalaria, ingreso a la unidad de cuidados intensivos, estadía en dicha unidad, falla de tratamiento y mortalidad a 30 días. El uso de FRP contribuyó a la atención del paciente mejorando el rendimiento diagnóstico y optimizando la terapia antimicrobiana en pacientes adultos inmunocomprometidos.

https://doi.org/10.1016/j.ram.2023.03.001

Shedding of infectious SARS-COV-2 in two asymptomatic children
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Reyes, Noelia S.

; Rodriguez, Pamela E.

; Ricarte, Carmen

; Echegoyen, Natalia

; Viegas, Mariana

; Varese, Augusto

; Ceballos, Ana

; Stryjewski, Martín E.

; Echavarria, Marcela

Medicina (Buenos Aires)

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jun 2023, Volume 83 N. 2 Pages 185 - 189

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Las infecciones asintomáticas por SARS-CoV-2 están asociadas a la transmisión viral y tienen un papel cla ve en la propagación de la pandemia. Comprender la excreción viral durante las infecciones asintomáticas es fundamental. Desafortunadamente, los datos sobre la infección asintomática por SARS-CoV-2 en niños son extremadamente limitados. Para determinar la presencia de excreción de virus viable, se siguió prospectivamente a dos niños sanos de una familia en la que ambos padres desarrollaron COVID-19 leve (abril 2021). La detección de SARS-CoV-2 se realizó por RT-PCR y el aislamiento del virus por cultivo celular a partir de muestras de saliva. Las muestras positivas se secuenciaron para identificar variantes de SARS-CoV-2. En las muestras de suero se determinó la presencia de anticuerpos utilizando un ensayo de ELISA (COVIDAR IgG). Ambos niños fueron positivos para SARS-CoV-2 y asintomáticos. Además, el virus creció en cultivos celulares a partir de muestras de saliva. Uno de los niños mantuvo SARS-CoV-2 via bles durante al menos 17 días después de la aparición de los síntomas de su padre. El período de aislamiento recomendado para contactos asintomáticos durante la adquisición de datos se había establecido en 10 días, sin embargo, este niño permaneció con virus viable más allá de ese período. Las muestras positivas de estos niños correspondieron al linaje B.1.1.28.1 (Gamma). En ambos niños asintomáticos se detectó anticuerpos IgG anti-Spike. Concluimos que los niños asintomáticos pueden representar una fuente de infección que no debe subestimarse durante esta pandemia.

Abstract Asymptomatic infections with SARS-CoV-2 are associ ated with viral transmission and have a key role in the propagation of the pandemic. Understanding viral shed ding during asymptomatic infections is critical. Unfor tunately, data on asymptomatic SARS-CoV-2 infection in children is extremely limited. To determine the presence of viral viable shedding, we prospectively followed two healthy children of a family where both parents devel oped mild COVID-19 (April 2021). SARS-CoV-2 detection was made by RT-PCR and virus isolation by cell culture from saliva samples. Positive samples were sequenced to identify variants of SARS-CoV-2. Serum samples were evaluated to determine the presence of antibodies using a single enzyme-linked immunosorbent assay (ELISA, COVIDAR IgG). Both children were SARS-CoV-2 positive and asymptomatic. In addition, the virus grew in cell cul ture from saliva samples. Furthermore, one child showed viable SARS-CoV-2 for at least 17 days after the onset symptoms from his father. The recommended isolation period for asymptomatic contacts during the acquisition of data had been established for 10 days; however, this child remained with viable virus beyond that period. The positive samples from both children were consistent with B.1.1.28.1 lineage (Gamma). In both asymptomatic children, anti-Spike IgG was detected. Asymptomatic children may represent a source of infection that should not be underestimated during this pandemic.

VALORES E TENSÕES NA POLÍTICA CULTURAL IBÉRICA. UM ESTUDO DE CASOS
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Morató, Arturo Rodriguez

; Lopes, João Teixeira

; Zamorano, Mariano Martín

; Ferro, Lígia

; Azevedo, Natália

; Sánchez Belando, María Victoria

; Andrade, María

; Rey, Uxío Novo

; Apolinário, Sónia

; Ricardo, José

Sociologia, Problemas e Práticas

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apr 2023, N. 101 Pages 9 - 28

Abstract This article focuses on the main contributions of the European project Uncharted on emerging values in European cultural governance, relying on a wide document analysis, focus groups and interviews with a plethora of actors. By analyzing four Iberian case studies we seek to identify the diversity of values that shape cultural policy decisions and practices, focusing on the tensions and conflicts between the actors involved and their valuations. It will be shown that actors mobilize around disputes over the hierarchy of values, which requires an understanding of the contexts in which each repertoire is established, even if the conflictuality is exercised within the same model of cultural policy, prevalent in the two Iberian countries.

Résumé Cet article se concentre sur les principales contributions du projet européen Uncharted sur les valeurs émergentes dans la gouvernance culturelle européenne, en s’appuyant sur une large analyse documentaire, des groupes de discussion et des entretiens avec une pléthore d’acteurs. En analysant quatre études de cas ibériques, nous cherchons à identifier la diversité des valeurs qui façonnent les décisions et les pratiques de la politique culturelle, en nous concentrant sur les tensions et les conflits entre les acteurs impliqués et leurs valorisations. On montrera que les acteurs se mobilisent autour de conflits sur la hiérarchie des valeurs, ce que nécessite une compréhension des contextes dans lesquels chaque répertoire est établi, même si la conflictualité s’exerce au sein d’un même modèle de politique culturelle, prévalant dans les deux pays ibériques.

Resumen Este artículo se centra en las principales aportaciones del proyecto europeo Uncharted sobre los valores emergentes en la gobernanza cultural europea, basándose en un amplio análisis documental, grupos de discusión y entrevistas con una gran cantidad de actores. Mediante el análisis de cuatro estudios de caso ibéricos se pretende identificar la diversidad de valores que conforman las decisiones y prácticas de política cultural, centrándose en las tensiones y conflictos entre los actores implicados y sus valoraciones. Se demostrará que los actores se movilizan en torno a las disputas sobre la jerarquía de valores, lo que exige comprender los contextos en los que se establece cada repertorio, aunque la conflictividad se ejerza dentro del mismo modelo de política cultural, predominante en los dos países ibéricos.

Resumo Este artigo centra-se nos principais contributos do projeto europeu Uncharted sobre os valores emergentes na administração cultural europeia, apoiando-se numa vasta análise documental, em grupos focais e entrevistas a uma plêiade de atores. Analisando quatro estudos de caso ibéricos, procura-se identificar a diversidade de valores que moldam as decisões e práticas de política cultural, com foco nas tensões e conflitos entre os atores envolvidos e as suas valorações. Demonstrar-se-á que os atores se mobilizam em torno de disputas sobre a hierarquia de valores, o que exige uma compreensão dos contextos em que cada reportório se estabelece, ainda que a conflitualidade se exerça dentro de um mesmo modelo de política cultural, prevalecente nos dois países ibéricos.

https://doi.org/10.7458/spp202310127658

Health and economic burden of sugar-sweetened beverages consumption in Brazil
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Perelli, Lucas

; Alcaraz, Andrea

; Vianna, Cid Manso de Mello

; Espinola, Natalia

; Cairoli, Federico Rodriguez

; Bardach, Ariel

; Palacios, Alfredo

; Balan, Dario

; Johns, Paula

; Augustovski, Federico

; Pichón-Rivière, Andrés

Cadernos de Saúde Pública

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2023, Volume 39 N. 12 elocation e00249422

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: Las bebidas azucaradas (BA) tienen una gran fuente de azúcar añadido y están asociadas con enfermedades no transmisibles (ENT), como la obesidad y la diabetes. Este estudio evaluó el impacto del consumo de las BA en la carga de enfermedad en Brasil, incluidas las muertes, los años de vida ajustados por discapacidad (AVAD) y los costos con la salud. Con el uso de una metodología de tres etapas, se evaluaron los efectos directos de las BA sobre la diabetes, las enfermedades cardiovasculares y el índice de masa corporal (IMC), la influencia del IMC en la incidencia de la enfermedad, y se estimó la carga económica y de salud utilizando los factores atribuibles a la población. Los resultados mostraron que el 2,7% de los casos de sobrepeso/obesidad en adultos y del 11% en niños fueron atribuibles a las BA. El consumo de las BA en Brasil generó 1.814.486 casos, 12.942 muertes, 362.088 AVAD y USD 2.915,91 millones en costos médicos relacionados con diabetes, enfermedades cardiovasculares, enfermedades oncológicas y otras ENT. Es necesario implementar políticas públicas para tratar el consumo de las BA, reconocido este como un factor de riesgo clave para las ENT.

Resumo: As bebidas açucaradas (BAs) são uma grande fonte de açúcar adicionado e estão associadas a doenças não transmissíveis (DNTs), como obesidade e diabetes. Este estudo avaliou o impacto do consumo de BAs sobre a carga de doenças no Brasil, incluindo óbitos, anos de vida ajustados por incapacidade (AVPIs) e custos de saúde. Usando uma metodologia de três estágios, examinamos os efeitos diretos das BAs sobre diabetes, doenças cardiovasculares e índice de massa corporal (IMC), a influência do IMC na incidência de doenças e estimamos o carga econômica e de saúde usando fatores atribuíveis à população. Os resultados mostraram que 2,7% dos casos de sobrepeso/obesidade em adultos e 11% em crianças foram atribuíveis a BAs. O consumo de BAs no Brasil levou a 1.814.486 casos, 12.942 mortes, 362.088 AVPIs e USD 2.915,91 milhões em custos médicos relacionados a diabetes, doenças cardiovasculares, doenças oncológicas e outras DNT. A implementação urgente de políticas públicas é crucial para enfrentar o consumo de BAs, reconhecido como um fator de risco fundamental para as DNT.

Abstract: Sugar-sweetened beverages (SSBs) are a major source of added sugar and are associated with noncommunicable diseases (NCDs) such as obesity and diabetes. This study assessed the impact of SSBs consumption on disease burden in Brazil, including deaths, disability-adjusted life years (DALYs), and healthcare costs. A 3-stage methodology was used to assess the direct effects of SSBs on diabetes, cardiovascular diseases, and body mass index (BMI), along with the influence of BMI on disease incidence. These assessments were then used to estimate the economic and health burden using population-attributable factors. Results showed that 2.7% and 11% of adult and children overweight/obesity cases were attributable to SSBs, respectively. SSBs consumption in Brazil led to 1,814,486 cases, 12,942 deaths, 362,088 DALYs, and USD 2,915.91 million in medical costs related to diabetes, cardiovascular diseases, oncological diseases, and other NCDs. Urgent implementation of public policies is crucial to address the consumption of SSBs, recognized as a key risk factor for NCDs.

https://doi.org/10.1590/0102-311xen249422

Association between chronic Anaplasma marginale and Babesia spp. infection and hematological parameters of taurine heifers
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Rahal, Natalia Machado

; Luz, Gabriela Bueno

; Martins, Kauê Rodriguez

; Gasperin, Bernardo Garziera

; Feijó, Josiane de Oliveira

; Dalto, André Gustavo Cabrera

; Rovani, Monique Tomazele

; Cunha, Rodrigo Casquero

; Corrêa, Marcio Nunes

Revista Brasileira de Parasitologia Veterinária

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2023, Volume 32 N. 3 elocation e006423

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The aim of this study was to investigate the association between chronic Anaplasma marginale and Babesia spp. infection and hematological parameters of pregnant and non-pregnant taurine heifers. Blood samples from 94 females were collected on the first day (D-10) of timed artificial insemination (TAI) protocol and on pregnancy diagnosis (D+34). Hematological parameters were determined and compared between pregnant (PG) and non-pregnant (NPG) heifers, and within group at different sampling days. Real-time PCR (qPCR) was used to determine A. marginale and Babesia bovis infection, and for absolute quantification of Babesia spp. between PG and NPG groups. Correlation analysis was performed between the number of gDNA copies (CN) of Babesia spp. and hematological parameters. On D-10, mean hemoglobin concentration was higher for NPG, and hematocrit and total plasma protein were higher on D+34 for both groups. There was no difference in Babesia spp. CN between groups. In the first qPCR, all heifers were positive for A. marginale and B. bovis. Significant correlations were found between hemoglobin and erythrocyte and between hemoglobin and hematocrit (r = 0.8082 and r = 0.3009, respectively). Low levels of A. marginale and Babesia spp. did not affect hematological parameters of chronically infected pregnant and non-pregnant taurine heifers.

Resumo O objetivo deste estudo foi investigar a associação entre infecção crônica por Anaplasma marginale e Babesia spp. e parâmetros hematológicos de novilhas taurinas prenhes e não prenhes. Sangue de 94 fêmeas foi coletado no primeiro dia (D-10) do protocolo de inseminação artificial em tempo fixo (IATF) e no diagnóstico de gestação (D+34). Parâmetros hematológicos foram comparados entre novilhas prenhes (PG) e não prenhes (NPG) e dentro dos grupos entre dias de coleta. Usando-se PCR em tempo real (qPCR), determinou-se a infecção por A. marginale e Babesia bovis e quantificação absoluta de Babesia spp. Entre os grupos PG e NPG. A análise de correlação foi realizada entre o número de cópias (CN) de Babesia spp. e parâmetros hematológicos. No D-10, a concentração de hemoglobina foi maior para NPG e hematócrito, e proteína plasmática total foram maiores em D+34 para ambos os grupos. Não houve diferença para CN de Babesia spp. entre os grupos. Na primeira qPCR, todas as novilhas foram positivas para A. marginale e B. bovis. Correlações significativas foram encontradas entre hemoglobina/eritrócito e hemoglobina/hematócrito (r=0,8082 e r=0,3009, respectivamente). Baixos níveis de A. marginale e Babesia spp. não afetaram os parâmetros hematológicos de novilhas taurinas prenhes e não prenhes cronicamente infectadas.

https://doi.org/10.1590/s1984-29612023052

Health and economic burden of sugar-sweetened beverages consumption in Brazil
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Perelli, Lucas

; Alcaraz, Andrea

; Vianna, Cid Manso de Mello

; Espinola, Natalia

; Cairoli, Federico Rodriguez

; Bardach, Ariel

; Palacios, Alfredo

; Balan, Dario

; Johns, Paula

; Augustovski, Federico

; Pichón-Rivière, Andrés

Cadernos de Saúde Pública

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2023, Volume 39 N. 12 elocation e00249422

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0102-311xen249422

Dinámica temporal de Epormenis cestri Berg (Hemiptera: Flatidae) y su asociación con los componentes del paisaje del Litoral entrerriano
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CAVIGLIASSO, Pablo

; MESSINA, Natalia

; BARRETO, Carolina G.

; ROMAN, Lilian

; BULACIO CAGNOLO, Natalia V.

; RODRIGUEZ, Graciela

Revista de la Sociedad Entomológica Argentina

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jun 2022, Volume 81 N. 1 Pages 41 - 51

Abstract: Es | Text: Es | PDF: Es

Abstract The condition called "river disease" (MDR by its acronym in Spanish) is an intoxication in immature stages of honey bees caused by a compound from the genus Sebastiania Spreng and concentrated in the exudates of Epormenis cestri Berg. Our objective was to determine the temporal dynamics of the life cycle of E. cestri, its association with the predominant vegetation components and the influence of the Uruguay river on the size of its populations. With this aim, we selected 5 sites in the vicinity of the Uruguay river where populations of E. cestri were sampled using the Stem-tap technique modified for this purpose. The effect of landscape components on the abundance of E. cestri was evaluated using GLMM. It was determined that the hatching of the E. cestri eggs was in mid-October, finding a staggered distribution of its phenophases. In addition, we found significantly negative effects of the Espinal forest cover and the increase in the distance from the banks of the Uruguay river on the total abundance of E. cestri. This work shows some first clues for the understanding of how the components of the landscape structure the populations of E. cestri, allowing to predict the critical moment of incidence of MDR.

Statin indication according to the 2019 World Health Organization cardiovascular disease risk charts and carotid ultrasound in Mexican mestizo rheumatoid arthritis patients
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Galarza-Delgado, Dionicio A.

; Colunga-Pedraza, Iris J.

; Azpiri-Lopez, Jose R.

; Guajardo-Jauregui, Natalia

; Rodriguez-Romero, Alejandra B.

; Loya-Acosta, Julieta

; Meza-Garza, Alejandro

; Cardenas-de la Garza, Jesus A.

; Lugo-Perez, Salvador

; Castillo-Treviño, Jessica N.

Advances in Rheumatology

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2022, Volume 62 elocation 4

Abstract: En | Text: En | PDF: En

Abstract Background: We aimed to assess the concordance of recommendation for initiating statin therapy according to the 2019 World Health Organization (WHO) cardiovascular disease (CVD) risk charts and to the presence of carotid plaque (CP) identified with carotid ultrasound in Mexican mestizo rheumatoid arthritis (RA) patients, and to determine the proportion of patients reclassified to a high cardiovascular risk after the carotid ultrasound was performed. Methods: This was a cross-sectional study nested of a RA patients’ cohort. A total of 157 Mexican mestizo RA patients were included. The cardiovascular evaluation was performed using the 2019 WHO CVD risk charts (laboratory-based model) for the Central Latin America region. A carotid ultrasound was performed in all patients. The indication to start statin therapy was considered if the patient was classified as high risk, moderate risk if > 40 years with total cholesterol (TC) > 200 mg/dl or LDL-C > 120 mg/dl, and low risk if > 40 years with TC > 300 mg/dl, according to the WHO CVD risk chart or if the patient had carotid plaque (CP). Cohen’s kappa (k) coefficient was used to evaluate the concordance between statin therapy initiation. Results: Initiation of statin therapy was considered in 49 (31.2%) patients according to the 2019 WHO CVD risk charts and 49 (31.2%) patients by the presence of CP. Cardiovascular risk reclassification by the presence of CP was observed in 29 (18.9%) patients. A slight agreement (k = 0.140) was observed when comparing statin therapy recommendations between 2019 WHO CVD risk charts and the presence of CP. Conclusion: The WHO CVD risk charts failed to identify a large proportion of patients with subclinical atherosclerosis detected by the carotid ultrasound and the concordance between both methods was poor. Therefore, carotid ultra-sound should be considered in the cardiovascular evaluation of RA patients.

https://doi.org/10.1186/s42358-022-00235-6

Cultura y comportamiento del consumidor de quinua como producto orgánico
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Flores Mamani, Emilio

; Rodriguez-Huamani, Rolando Esteban

; Arce-Ortiz, Natalia Verónica

; García-Tejada, Gino Félix

Idesia (Arica)

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2022, Volume 40 N. 2 Pages 133 - 142

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT The consumption of organic products such as quinoa in recent years has transcended in the context of the gastronomy of rural and urban homes due to its high nutritional value to counteract diseases. The article aims to characterize the profile of culture and consumer behavior of quinoa in its different presentations and in different countries where households include it in their diet. The methodology used to prepare the review databases such as Scopus, SciELO, Redalyc and and other publications on the consumption of quinoa were consulted and through the descriptive analysis of the limited existing studies on it consumption, the culture and consumer behavior of quinoa were characterized. The results reveal that the consumer ingests quinoa for breakfast, lunch and dinner in whole grain as well as processed in different presentations, as well as the green leaves and the incinerated stem, depending on the taste of consumers, the countries that consume the most in South America They are Bolivia, Peru and others. Quinoa is consumed not only by rural households, but has also transcended in the households of urban segments in different countries. In conclusion is that it contributes with important information to enrich the literature on the behavior of the consumer of quinoa in a scenario of constant changes in search of a healthy diet, to counteract certain diseases that afflict humanity.

RESUMEN El consumo de productos orgánicos como la quinua en los últimos años ha trascendido en el contexto de la gastronomía de los hogares rurales y urbanos, por su alto valor nutricional para contrarrestar enfermedades. El artículo tiene como objetivo caracterizar el perfil de cultura y comportamiento del consumidor de quinua en sus diferentes presentaciones y en distintos países donde los hogares la incluyen en su alimentación. Para elaborar la revisión se consultaron bases de datos como Scopus, SciELO, Redalyc y otras publicaciones en torno al consumo de la quinua, y mediante el análisis descriptivo de los limitados estudios existentes se caracterizó la cultura y el comportamiento del consumidor. Los resultados muestran que la quinua se come en el desayuno, almuerzo y cena como grano entero y procesados en diferentes presentaciones, así como las hojas verdes y el tallo incinerado, dependiendo del gusto de los consumidores. Los países que más la consumen en Sudamérica son Bolivia, Perú y Ecuador. La quinua es utilizada no solo en los hogares rurales, sino también en los de segmentos urbanos en diversos países. En conclusión es que se contribuye con información importante para enriquecer la literatura sobre el comportamiento del consumidor de quinua, en un escenario de constantes cambios en busca de una alimentación saludable, a fin de contrarrestar ciertas enfermedades que aquejan a la humanidad.

10.

Neumotoxicidad y hepatotoxicidad por Crotalaria pallida en el modelo de intoxicación subcrónica en ovinos
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Jaramillo-Hernández, Dumar Alexander

; Tamayo Rojas, Doris Juliette

; Cifuentes Sánchez, Diana Consuelo

; Veloza Angulo, Luis Carlos

; Molina Diaz, Víctor Manuel

; Pedraza Castillo, Luz Natalia

; Roque Rodriguez, Anita Isabel

Revista de Investigaciones Veterinarias del Perú

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nov 2021, Volume 32 N. 6 elocation e19923

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN El objetivo del estudio fue evaluar el potencial de intoxicación subcrónica de Crotalaria pallida en ovinos. Se utilizaron seis carneros, alimentados con heno y agua potable ad libitum, y 200 g/animal/día de ración balanceada comercial. Los ovinos fueron distribuidos en un grupo control (G1) con dos animales y un grupo experimental (G2) con cuatro animales. En la dieta de G2 se incluyó 8 g de materia seca (MS) de C. pallida por kilogramo de peso vivo durante 28 días. Todos los animales fueron evaluados clínicamente c/24 h. Se les pesó y se tomaron muestras de sangre para hemograma y perfil hepático y renal en los días 0, 14 y 28 posexposición a C. pallida. Los animales fueron sacrificados al final del estudio para la toma de muestras para análisis histopatológico. No se encontraron diferencias significativas entre grupos con respecto al examen clínico, hemograma y bioquímica sanguínea; sin embargo, en el estudio histopatológico se evidenció engrosamiento moderado de los septos alveolares en pulmón, cambio vacuolar severo en hígado y proteinuria moderada en riñón en los animales expuestos a C. pallida.

ABSTRACT The aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida.

https://doi.org/10.15381/rivep.v32i6.19923

11.

Hantavirus en la selva peruana: una revisión sistemática de series y casos reportados
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Saavedra-Velasco, Marcos

; Oyarce-Calderón, Alvaro

; Herrera, Natalia Vargas

; Pichardo-Rodriguez, Rafael

; Moreno-Arteaga, Carlos M.

Revista de la Facultad de Medicina Humana

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oct 2021, Volume 21 N. 4 Pages 851 - 858

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Hantavirosis is a zoonotic infection transmitted mainly by rodents. In Peru, a lethality of 40-60% is calculated in inhabitants of the Peruvian Amazon jungle, especially in Loreto. Despite this, this disease continues to be under-diagnosed despite the fact that it represents a serious problem for public health in Latin America. We present a systematic revision of case reports and series of cases of Hantavirus infection in the Peruvian jungle. The most important characteristic of the cases presented are mean age 25.7 years, predominance of female sex (5/6), clinical presentation of headache, myalgias, nausea and vomiting (6/6) and unfavorable evolution to acute respiratory distress syndrome (ARDS), renal failure, septic shock and multiple organ failure in 3 of the cases presented.

RESUMEN La hantavirosis es una infección zoonótica transmitida principalmente por roedores. En el Perú, se calcula una letalidad del 40-60% en pobladores de la selva amazónica peruana, especialmente en Loreto. A pesar de ello, esta enfermedad continúa siendo sub-diagnosticada a pesar que representa un problema serio para la salud pública en Latinoamérica. Presentamos una revisión sistemática de reportes y series de casos de infección por Hantavirus procedentes de la selva peruana. Las características más importantes de los casos presentados son: media de edad 25.7 años, predominio del sexo femenino (5/6), presentación clínica de cefalea, mialgias, nausea y vómitos (6/6), y evolución desfavorable a distrés respiratorio agudo (SDRA), falla renal, shock séptico y falla multiorgánica en 3 de los casos presentados.

https://doi.org/10.25176/rfmh.v21i4.3650

12.

Clinical characteristics and evolution of hematological patients and COVID-19 in Argentina: a report from the Argentine Society of Hematology
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Basquiera, Ana L.

; García, Mercedes J

; Martinez Rolón, Juliana

; Olmedo, Julieta

; Laviano, Julia

; Burgos, Rubén

; Caeiro, Gastón

; Remaggi, Guillermina

; Raña, Pablo

; Paoletti, Mariano

; González, Carlos M.

; Fernández, Isolda

; Pavlovsky, Astrid

; Perusini, Maria A.

; Rodriguez, Andrea

; Guanchiale, Luciana

; Carvani, Analia

; Mandrile, Laura

; Figueroa, Flavia

; Vicente Reparaz, Ángeles

; Fragapane Mathus, Patricia N.

; Garate, Gonzalo

; Fauque, María E.

; Kantor, Gustavo

; Cruset, Soledad

; Gonzalez Lorch, Jacqueline S.

; Szelagowski, Milagros

; Giarini, María P.

; Oliveira, Natalia

; García, María C.

; Ventriglia, María V.

; Pereyra, Patricio H.

; Gutierrez, Daniel R.

; Kusminsky, Gustavo

; Troccoli, Josefina

; Freitas, María J.

; Cranco, Santiago

; Del V.Sanchez, Natalia

; Rey, Irene

; Funes, María E.

; Jarchum, Sol

; Freue, Julian

; Miroli, Augusto

; Guerrero, Osvaldo

; López Ares, Lisa

; Campestri, Reinaldo

; Bove, Victor

; Salinas, Graciela N.

; Cabrejo, María

; Milone, Jorge H.

; Zabaljauregui, Soledad

; Gotta, Daniel

; Dupont, Juan Carlos

; Stemmelin, German

Medicina (Buenos Aires)

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aug 2021, Volume 81 N. 4 Pages 536 - 545

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Individuals with malignancies and COVID-19 have a lower survival compared with the general population. However, the information about the impact of COVID-19 on the whole hematological population is scarce. We aimed to describe the 30th day overall survival (OS) after COVID-19 infection in pa tients with a hematological disease in Argentina. A completely anonymous survey from the Argentine Society of Hematology was delivered to all the hematologists in Argentina; it started in April 2020. A cut-off to analyze the data was performed in December 2020 and, finally, 419 patients were reported and suitable for the analysis (average age: 58 years, 90% with malignant diseases). After the COVID-19 diagnosis, the 30-day OS for the whole population was 80.2%. From the entire group (419), 101 (24.1%) individuals required intensive care unit admission, where the 30-day OS was 46.6%. Among allogeneic stem cell transplant recipients, the 30-day OS was 70.3%. Factors associated with a low OS were two or more comorbidities, an active hematological disease and history of chemotherapy. In individuals with the three factors, the 30-day OS was 49.6% while the 30-day OS in those without those factors was 100%. Patients with hematological diseases have a higher mortality than the general population. This group represents a challenge and requires careful decision-making of the treatment in order not to compromise the chances of cure.

Resumen El presente estudio tuvo por objetivo primario conocer la mortalidad de pacientes con enfermedad hematológica que presentaron infección por COVID-19 en Argentina. Para ello se difundió una encuesta desde la Sociedad Argentina de Hematología (SAH) entre los hematológos para informar sobre los pacientes con enfermedades hematológicas y diagnóstico de infección por SARS- CoV-2, entre el 19/4/2020, y el 7/12/2020. Se incluyeron individuos de todas las edades con diagnóstico de enfermedad hematológica benigna o maligna e infección por SARS-CoV-2 confirmada por técnica de RT-PCR. Se analizaron 419 pacientes (mediana 58 años; 90% enfermedades malignas). La supervivencia al día 30 fue de 80.2%. La supervivencia fue menor en aquellos que requirieron internación (74.2%), cuidados intensivos (46.6%) y asistencia respiratoria mecánica (36.8%). Entre los trasplantados alogénicos la supervivencia fue 70.3%. Los factores vinculados a la supervivencia global fueron las comorbilidades, el estado de la enfermedad al momento de la infección y el antecedente de quimioterapia. Se pudo establecer un score en el que aquellos que tuvieron un puntaje de 4 alcanzaron una supervivencia del 49.6% al día 30, mientras que la de los pacientes con score 0 fue del 100% a 30 días. En comparación con la población general, los pacientes con enfermedades hematológicas presentan una mayor mortalidad vinculada al COVID-19, motivo por el cual es primordial definir pautas destinadas a disminuir la exposición de los mismos sin comprometer las posibilidades de beneficiarse del tratamiento de la enfermedad de base.

121 downloads

13.

Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study
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Lima-Setta, Fernanda

; Magalhães-Barbosa, Maria Clara de

; Rodrigues-Santos, Gustavo

; Figueiredo, Elaine Augusta das Neves

; Jacques, Melissa de Lorena

; Zeitel, Raquel de Seixas

; Sapolnik, Roberto

; Borges, Cibelle Teixeira da Siva

; Lanziotti, Vanessa Soares

; Castro, Roberta Esteves Vieira de

; Bellinat, Ana Paula Novaes

; Silva, Thiago Peres da

; Oliveira, Felipe Rezende Caino de

; Reis, Bárbara Carvalho Santos dos

; Castro, Natália Almeida de Arnaldo Silva Rodriguez

; Macedo, João Henrique Garcia Cobas

; Scarlato, Ana Carolina Cabral Pinheiro

; Riveiro, Paula Marins

; Mota, Isabele Coelho Fonseca da

; Lorenzo, Vivian Botelho

; Lucena, Natalia Martins Lima de

; Azevedo, Zina Maria Almeida de

; Cunha, Antonio José L.A.

; Prata-Barbosa, Arnaldo

Jornal de Pediatria

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jun 2021, Volume 97 N. 3 Pages 354 - 361

Abstract: En | Text: En | PDF: En

Abstract Objective To describe the clinical, laboratory, and radiological characteristics, as well as the outcomes of children with MIS-C. Method Multicenter, prospective cohort study, conducted in 17 pediatric intensive care units in five states in Brazil, from March to July 2020. Patients from 1 month to 19 years who met the MIS-C diagnostic criteria were included consecutively. Results Fifty-six patients were included, with the following conditions: Kawasaki-like disease (n = 26), incomplete Kawasaki disease (n = 16), acute cardiac dysfunction (n = 10), toxic shock syndrome (n = 3), and macrophage activation syndrome (n = 1). Median age was 6.2 years (IQR 2.4−10.3), 70% were boys, 59% were non-whites, 20% had comorbidities, 48% reported a contact with COVID-19 cases, and 55% had a recent SARS-CoV-2 infection confirmed by RT-PCR and/or serology. Gastrointestinal symptoms were present in 71%, shock symptoms in 59%, and severe respiratory symptoms in less than 20%. -Dimer was increased in 80% and cardiac dysfunction markers in more than 75%. Treatment included immunoglobulin (89%); corticosteroids, antibiotics, and enoxaparin in about 50%; and oseltamivir and antifungal therapy in less than 10%. Only 11% needed invasive mechanical ventilation, with a median duration of five days (IQR 5–6.5). The median length of PICU stay was six days (IQR 5–11), and one death occurred (1.8%). Conclusions Most characteristics of the present MIS-C patients were similar to that of other cohorts. The present results may contribute to a broader understanding of SARS-CoV-2 infection in children and its short-term consequences. Long-term multidisciplinary follow-up is needed, since it is not known whether these patients will have chronic cardiac impairment or other sequelae.

https://doi.org/10.1016/j.jped.2020.10.008 281 downloads

14.

Síndrome de Miescher-Melkersson-Rosenthal: Presentación de tres casos y revisión de la literatura
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Romero Hernández, Camilo Andrés

; Ramirez Rodriguez, Natalia

Acta Neurológica Colombiana

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jun 2021, Volume 37 N. 2 Pages 75 - 79

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN El síndrome de Miescher-Melkerson-Rosenthal es una condición clínica poco frecuente caracterizada por un edema orofacial episódico, paresia facial periférica recurrente, lengua geográfica (lingua plicata) y granulomas en biopsia de piel o labial. Se ha reportado más frecuentemente en mujeres, y su incidencia es probablemente subestimada por el desconocimiento del síndrome, su presentación clínica incompleta y la plétora de diagnósticos diferenciales. Se debe considerar en pacientes que presenten al menos dos de las cuatro características mencionadas. Su tratamiento, con esteroides vía oral, está dirigido a los episodios de edema orofacial y/o paresia facial. A continuación se describen tres casos del síndrome valorados en el servicio de neurología de la Fundación Cardioinfantil y se presenta una breve revisión de la literatura.

SUMMARY Miescher-Melkerson-Rosenthal syndrome is an uncommon clinical condition characterized by episodic orofacial oedema, recurrent peripheral facial paralysis, geographic tongue (lingua plicata) and granulomas in skin or labial biopsy. It is reported more frequently in women, and its incidence is probably underestimated due to lack of knowledge of the syndrome, incomplete clinical presentation and the plethora of differential diagnosis. It should be considered in patients with at least two of the four mentioned characteristics. Its treatment, with oral steroids, is directed at the episodes of orofacial oedema and/or the facial paralysis. We described three cases of the syndrome seen at the Fundacion Cardioinfantil's neurology service and present a short review of the literature.

https://doi.org/10.22379/24224022370 179 downloads

15.

Confianzas y sospechas en el campo de la seguridad.
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Castro, Natalia Sofía

; Rodriguez, Florencia

Runa

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apr 2021, Volume 42 N. 1 Pages 175 - 192

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Neste artigo propomos-nos, como objetivo, fazer reflexões metodológicas sobre as nossas experiências como investigadores no campo da segurança. Explicamos alguns nós problemáticos em torno do trabalho de investigação qualitativa no contato direto com a polícia, em parte para abrir debates e discussões no campo das ciências sociais, mas também como uma reflexividade para nossas investigações em andamento. Antecipamos que o espírito do artigo tente debater alguns aspectos do “acesso” ao trabalho de campo dentro da instituição policial, ressaltando a relação entre a suposta opacidade e a predisposição de seus agentes em nos atender e responder às nossas perguntas. Para isso, abordamos alguns momentos da nossa pesquisa que nos permitem identificar e refletir sobre as nossas estratégias de construção da confiança e alguns mal-entendidos que suscitam manifestações de desconfiança sobre nossas intenções.

Abstract This article has the objective of making methodological reflections on our experiences as researchers in the field of security. We explain some problematic knots around the office of qualitatively investigating in direct contact with the police, partly to open debates and discussions within the field of social sciences, but also as a reflexivity exercise for our ongoing investigations. We anticipate that the spirit of the article attempts to resolve some aspects of “access” to field work within the police institution, stressing the relationship between the alleged opacity and the predisposition of its agents to meet us and answer our questions. To do so, we address some moments of our research that allow us to identify and reflect on our strategies to build trust and some misunderstandings that gave rise to expressions of suspicion about ourselves and our intentions.

Resumen En este artículo nos planteamos el objetivo de hacer reflexiones metodológicas sobre nuestras experiencias como investigadoras en el campo de la seguridad. Explicitamos algunos nudos problemáticos en torno al oficio de investigar cualitativamente en contacto directo con la policía, en parte para abrir debates y discusiones dentro del campo de las ciencias sociales, pero también a modo de reflexividad para nuestras indagaciones en curso. Adelantamos que el espíritu del artículo intenta dirimir algunos aspectos sobre el “acceso” al trabajo de campo dentro de la institución policial, que tensiona la relación entre la presunta opacidad y la predisposición de sus agentes para encontrarse con nosotras y responder nuestras preguntas. Para ello, abordamos algunos momentos de nuestra pesquisa que nos permiten identificar y reflexionar en torno de nuestras estrategias para construir confianza y algunos equívocos que dan lugar a expresiones de sospecha sobre nuestra persona y nuestras intenciones.

https://doi.org/10.34096/runa.v42i1.8472 69 downloads

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