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Secuelas cognitivas en encefalitis inmunomediadas: cohorte de pacientes en Argentina
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Palacios, Sara

; Manin, Analisa

; Dorman, Guido S.

; Kim, Leandro M.

; Núñez, María Rosa

; Villa, Andrés M.

Medicina (Buenos Aires)

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aug 2023, Volume 83 N. 3 Pages 402 - 410

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: Las encefalitis inmunomediadas son un desorden neurológico de origen autoinmune. Actual mente es escasa la descripción de las secuelas cognitivas crónicas. El objetivo del presente trabajo fue caracterizar la secuela cognitiva de diferentes tipos de encefalitis inmunomediadas en una cohorte de un centro único de Argentina. Métodos: Estudio prospectivo, observacional, trans versal, de pacientes en seguimiento en un hospital de la Ciudad de Buenos Aires, con diagnóstico de encefalitis inmunomediada probable y definitiva. Se evaluaron variables epidemiológicas, clínicas, paraclínicas y tra tamiento. Se determinó la secuela cognitiva a través de una evaluación neurocognitiva realizada a partir del año de la presentación clínica. Resultados: Fueron incluidos 15 pacientes, todos con resultado disminuido en al menos un test. La memoria fue el dominio más afectado. Aquellos que se encon traban bajo tratamiento inmunosupresor al momento de evaluarse presentaron menores resultados en el aprendizaje seriado (media -2.94; desvío estándar 1.54) versus los que se encontraban sin tratamiento (media -1.18; desvío estándar 1.40; p = 0.05) y en la prueba de reconocimiento (media -10.34; desvío estándar 8.02) ver sus sin tratamiento (media -1.39; desvío estándar 2.21; p = 0.003). Los pacientes con estatus epiléptico tuvieron resultados deficitarios en la prueba de reconocimiento (media -7.2; desvío estándar 7.91) en comparación a los que no lo tenían (media -1.47; desvío estándar 2.34; p = 0.05). Conclusión: Nuestros resultados demuestran que, a pesar del curso monofásico de la enfermedad, todos los pacientes presentan daño cognitivo persistente más allá del año del inicio del cuadro. Estudios prospectivos de mayor envergadura serían necesarios para confirmar nuestros hallazgos.

Abstract Introduction: Autoimmune encephalitis represents a group of immune-mediated neurological disorders. At present, the description of the chronic cognitive sequela is scarce. The objective of this study was to characterize the cognitive after effects of different types of autoimmune encephalitis in a cohort from a single center in Argentina. Methods: Prospective, observational, cross-sectional study of patients under follow-up at a hospital in Buenos Aires city, with a diagnosis of probable and definitive immune-mediated encephalitis. Epidemiological, clini cal, paraclinical and treatment related variables were evaluated. Cognitive sequela was determined through a neurocognitive evaluation performed at least a year after the clinical presentation. Results: Fifteen patients were included. All had di minished results in at least one test. Memory was the most affected domain. Patients who were under im munosuppressive treatment at the time of evaluation presented lower results in serial learning (mean -2.94; standard deviation 1.54) versus those who weren’t under treatment (mean -1.18; standard deviation 1.40; p = 0.05). The same pattern was observed on the recognition test of treatment group (mean -10.34; standard deviation 8.02) versus treatment-free group (mean -1.39; standard deviation 2.21; p =0.003). Patients with status epilepticus had poorer results in the recognition test (mean -7.2; standard deviation 7.91) compared to those without it (mean -1.47; standard deviation 2.34; p = 0.05). Conclusion: Our results show that, despite the mo nophasic course of this disease, all patients had persis tent cognitive damage beyond the year of onset. Larger prospective studies are required to confirm our findings.

Self-reported and objective sleep duration in patients with CKD: are they telling the same story?
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Carvalho, Kalyanna S. Bezerra de

; Lauar, Julia C.

; Drager, Luciano F.

; Moyses, Rosa M.A.

; Elias, Rosilene M.

Brazilian Journal of Nephrology

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mar 2023, Volume 45 N. 1 Pages 102 - 105

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: There is disagreement between data on sleep duration obtained from questionnaires and objective measurements. Whether this is also true for individuals with CKD is unknown. Here we compared self-reported sleep duration with sleep duration obtained by actigraphy. Methods: This prospective study included adult individuals with stage 3 CKD recruited between September/2016 and February/2019. We evaluated subjective sleep duration by asking the following question: “How many hours of actual sleep did you get at night?” Results: Patients (N=34) were relatively young (51 ± 13 years). Self-reported and measured sleep duration were 7.1 ± 1.7 and 6.9 ± 1.6 hours, respectively, with no correlation between them (p=0.165). Although the mean difference between measurements was 0.21 h, the limits of agreement ranged from -3.7 to 4.1 h. Conclusion: Patients with CKD who are not on dialysis have an erroneous sleep perception. Data on sleep duration should be preferentially obtained from objective measurements in patients with CKD.

Resumo Introdução: Há discordância entre os dados sobre duração do sono obtidos a partir de questionários e medições objetivas. Não se sabe se isto também é verdade para indivíduos com DRC. Aqui comparamos a duração do sono autorrelatada com a duração do sono obtida por meio de actigrafia. Métodos: Este estudo prospectivo incluiu indivíduos adultos com DRC estadio 3 recrutados entre Setembro/2016 e Fevereiro/2019. Avaliamos a duração subjetiva do sono, fazendo a seguinte questão: “Quantas horas de sono real você teve à noite?” Resultados: Os pacientes (N=34) eram relativamente jovens (51 ± 13 anos). A duração do sono autorrelatada e mensurada foi de 7,1 ± 1,7 e 6,9 ± 1,6 horas, respectivamente, sem correlação entre elas (p=0,165). Embora a diferença média entre as medições tenha sido de 0,21 h, os limites de concordância variaram de -3,7 a 4,1 h. Conclusão: Pacientes com DRC que não estão em diálise apresentam uma percepção equivocada do sono. Dados sobre a duração do sono devem ser obtidos preferencialmente a partir de medições objetivas em pacientes com DRC.

https://doi.org/10.1590/2175-8239-jbn-2022-0015en

Tasa de recurrencia e implicación del margen quirúrgico en la supervivencia del paciente con melanoma acral. ¿Es necesario un margen amplio?
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Lino-Silva, Leonardo S.

; Hernández-Romero, Raúl

; García-Herrera, Juan S.

; Zepeda-Najar, César

; Salcedo-Hernández, Rosa A.

; León-Takahashi, Alberto M.

; Escobar-Jiménez, Marín G.

; Herrera-Gómez, Ángel

Gaceta médica de México

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feb 2023, Volume 159 N. 1 Pages 38 - 43

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: La extensión apropiada de los márgenes de resección en el melanoma acral no está claramente establecida. Objetivo: Investigar si la escisión con margen estrecho es adecuada en el melanoma acral grueso. Métodos: Se estudiaron 306 pacientes con melanoma acral. Conforme a la extensión del margen quirúrgico (de 1 a 2 cm y > 2 cm), se analizaron los factores asociados a la recurrencia y la supervivencia. Resultados: De 306 pacientes, 183 fueron mujeres (59.8 %). La mediana del grosor de Breslow fue 6 mm; 224 casos (73.2 %) fueron de tipo ulcerados, 154 pacientes (50.3 %) tenían enfermedad en estadio clínico III, 137 en II (44.8 %) y 15 en IV (4.9 %). Todos los casos presentaron margen negativo, con una mediana de 31.5 mm. Un grosor de Breslow de 7 mm (p = 0.001) y la etapa clínica III (p = 0.031) se asociaron a recurrencia; los factores asociados a la supervivencia fueron el índice de Breslow (p = 0.047), la ulceración (p = 0.003), la etapa clínica avanzada (p < 0.001) y el uso de adyuvancia (p = 0.003). Conclusión: Un margen de resección de 1 a 2 cm no afectó la recurrencia tumoral ni la supervivencia en los pacientes con melanoma acral.

Abstract Introduction: Appropriate size of resection margins in acral melanoma is not clearly established. Objective: To investigate whether narrow-margin excision is appropriate for thick acral melanoma. Methods: Three-hundred and six patients with acral melanoma were examined. Factors associated with recurrence and survival were analyzed according to surgical margin size (1 to 2 cm and > 2 cm). Results: Out of 306 patients, 183 were women (59.8%). Median Breslow thickness was 6 mm; 224 cases (73.2%) were ulcerated, 154 patients (50.3%) had clinical stage III disease, while 137 were at stage II (44.8%) and 15 at stage IV (4.9%). All cases had negative margins, with a median of 31.5 mm. A Breslow thickness of 7 mm (p = 0.001) and clinical stage III (p = 0.031) were associated with recurrence; the factors associated with survival were Breslow index (p = 0.047), ulceration (p = 0.003), advanced clinical stage (p < 0.001), and use of adjuvant therapy (p = 0.003). Conclusion: A resection margin of 1 to 2 cm did not affect tumor recurrence or survival in patients with acral melanoma.

https://doi.org/10.24875/gmm.22000192

ANAEROBIC CO-DIGESTION OF SWINE AND LAYING HEN WASTE FOR BIOGAS GENERATION AND DIGESTATE QUALITY
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Pereira, Flávia E. de A.

; Rosa, André P.

; Borges, Eduardo S. M.

; Otenio, Marcelo H.

; Souza, Letícia D. de

; Nascimento, Juliana E. L. do

; Borges, Alisson C.

Engenharia Agrícola

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2023, Volume 43 N. spe elocation e20220124

Abstract: En | Text: En | PDF: En

ABSTRACT Anaerobic digestion (AD) stands out as a degradation pathway for the treatment of agro-industrial waste. This study aimed to evaluate the biogas production (Pb) from the co-digestion of swine (SW) and laying hen waste (LHW) under different temperature conditions (psychrophilic x mesophilic). The studies were carried out on a laboratory scale in anaerobic reactors (1.25 L) in a batch system for 60 days. Three mixtures in volumetric proportions (%) of 25/75 (P1), 50/50 (P2), and 75/25 (P3) (SW/LHW) were studied. The mixtures were characterized before and after AD in terms of TS, VS, and COD under temperatures of 18 and 36 °C, with Pb measured daily. Pb was higher at 36 °C for all mixtures compared to the psychrophilic condition (18 °C). Among the mixtures, the highest Pb value was observed for P3, reaching 0.34 and 0.60 m3 biogas kg−1 CODremoved for 18 and 36 °C, respectively. The digestate showed an increase in the contents of micro-and macronutrients for P1, P2, and P3 after AD, which indicates its use for agricultural purposes. The co-digestion of swine and laying hen waste is a promising proposal in terms of management and energy recovery of biogas, especially for mesophilic conditions in mixtures with a predominance of laying hen waste.

https://doi.org/10.1590/1809-4430-eng.agric.v43nepe20220124/2023

xButyagrus nabonnandii (Prosch.) Vorster (Arecaceae): a sterile and rare palm with variable morphology?
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Rosa, L. Z.

; Sant’Anna-Santos, B. F.

; Almeida, C. G. M.

; Kuhn, S. A.

; Hüther, C. M.

; Souza, V. Q.

Brazilian Journal of Biology

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2023, Volume 83 elocation e271366

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract ×Butyagrus nabonnandii (Prosch.) Vorster is known as mule palm due to sterility, but recently, its pollen has been successfully used in backcrosses. It was first described as an artificial cross between Syagrus romanzoffiana (Cham.) Glassman and Butia odorata (Barb.Rodr.) Noblick in 1890. It has been considered rare in nature, and its morphology has been little studied. Thus, we aimed to verify if ×B. nabonnandii is sterile by studying its morphology and seed germination from different natural populations. The hybrid was sampled in four municipalities and is new to three of these. In one of the visited cities, 20 specimens were counted. The vegetative morphology showed less variation than the reproductive. However, part of the vegetative characters differed from previous descriptions relying solely on cultivated specimens. Contrary to previous reports, our data indicate that ×Butyagrus nabonnandii is neither rare nor infertile. Seed germination rates of ×B. nabonnandii are low due to seed predation by beetle larvae and seedless fruit production, which is also observed in the genera of the parental species. Furthermore, as in its parents, the morphology of the hybrid is complex, and future anatomical and molecular approaches are important for a better delimitation and understanding of the biology of ×B. nabonnandii.

Resumo ×Butyagrus nabonnandii (Prosch.) Vorster é conhecida como palmeira-mula por ser considerada estéril, apesar de ter sido utilizada com sucesso em retrocruzamentos. O híbrido resulta do cruzamento entre Syagrus romanzoffiana (Cham.) Glassman e Butia odorata (Barb.Rodr.) Noblick, é tido como raro e possui morfologia pouco estudada. Objetivou-se estudar a morfologia de ×B. nabonnandii e verificar sua esterilidade através da germinação de suas sementes a partir de diferentes populações naturais. O híbrido foi registrado em quatro municípios sendo, em três desses, de ocorrência inédita. Em um dos municípios visitados, foram contabilizados 20 espécimes. A morfologia vegetativa apresentou menor variação do que a reprodutiva. Entretanto, parte dos caracteres morfológicos vegetativos diferem do descrito na literatura para espécimes cultivados. Nossos dados indicam que além de não ser raro, o híbrido é fértil. As taxas de germinação das sementes de ×B. nabonnandii são baixas devido à predação das sementes por larvas de besouros, além da produção de frutos sem sementes, o que também ocorre nos gêneros das espécies progenitoras. Além disso, assim como em seus parentais, a morfologia do híbrido é complexa, sendo importantes futuros estudos anatômicos e moleculares para uma melhor delimitação e compreensão da biologia de ×B. nabonnandii.

https://doi.org/10.1590/1519-6984.271366

Risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy in thyroid nodules with diameters greater than 4 centimeters
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Barcelos, Rafaela N.

; Camacho, Cléber P.

; Mamone, Maria da Conceição de O. C.

; Ikejiri, Elza S.

; Vanderlei, Felipe A. B.

; Yang, Ji H.

; Padovani, Rosália P.

; Martins, Leandro A. L.

; Biscolla, Rosa Paula M.

; Macellaro, Danielle

; Lindsey, Susan C.

; Maciel, Rui M. B.

; Martins, João Roberto M.

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 6 elocation e000644

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: The risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy (FNAB) of thyroid nodules (TN) with diameters ≥ 3-4 cm remains controversial. However, some groups have indicated surgical treatment in these patients regardless of the FNAB results. We aimed to evaluate the diagnostic accuracy of the FNAB in systematically resected ≥4 cm TN and if the risk of malignancy is higher in these patients. Subjects and methods: We retrospectively evaluated 138 patients (142 nodules) with TN with diameters ≥4 cm who underwent thyroidectomy. Results: The FNAB results were nondiagnostic/unsatisfactory (ND/UNS) in 2.1% of the cases and benign in 51.4%. They indicated atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in 23.9% of cases, follicular neoplasia/suspicious for a follicular neoplasm (FN/SFN) in 9.2%, suspicion of malignancy (SUS) in 8.5%, and malignant in 4.9%. The histopathological analysis after thyroidectomy revealed a thyroid cancer rate of 100% in the FNABs classified as malignant, 33.3% in SUS cases, 7.7% in FN/SFN, 17.6% in AUS/FLUS, and 4.1% in benign FNABs. None of the ND/UNS FNABs were malignant. The global malignancy diagnosis was 14.8% (n = 21). However, the rate of false negatives for FNAB was low (4.1%). Conclusion: We showed that the risk of malignancy in nodules with diameters ≥4 cm was higher compared to the risk of thyroid cancer in TN in general. However, we found a low rate of false-negative cytological results; therefore, our data do not justify the orientation of routine resection for these larger nodules.

https://doi.org/10.20945/2359-3997000000644

Association study between ceftriaxone and a synthetic amide against strains of Pseudomonas aeruginosa
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Rosa, L. L. S.

; Andrade-Júnior, F. P.

; Cordeiro, L. V.

; Souza, H. D. S.

; Athayde-Filho, P. F.

; Gadelha, D. D. A.

; Melo, D. M.

; Silva, D. F.

; Alves, D. N.

; Sobreira, A. L. C.

; Ferreira, S. R. D.

; Teixeira, A. P. C.

; Farias, B. K. S.

; Firmino, R. G.

; Maia, A. K. H. L.

; Lima, E. O.

Brazilian Journal of Biology

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2023, Volume 83 elocation e274149

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Pseudomonas aeruginosa is a non-lactose fermenting Gram-negative bacteria responsible for causing numerous nosocomial infections. The present research aimed to analyze the anti-Pseudomonas aeruginosa potential of 2-Chloro-N-(4-fluoro-3-nitrophenyl)acetamide (A8). The antibacterial potential of A8 was evaluated from the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Association using the checkerboard method. MIC and MBC values were 512 µg/mL for all P. aeruginosa strains evaluated, demonstrating predominantly bactericidal activity. Furthermore, when A8 was associated with the drug ceftriaxone, pharmacological additivity and indifference were evidenced. In this sense, the synthetic amide was interesting, since it demonstrates the potential to become a possible candidate for an antimicrobial drug.

Resumo Pseudomonas aeruginosa é uma bactéria Gram-negativa não fermentadora de lactose, responsável por causar inúmeras infecções nosocomiais. A presente pesquisa teve como objetivo analisar o potencial anti-Pseudomonas aeruginosa da molécula 2-Cloro-N-(4-fluoro-3-nitrofenil)acetamida (A8). O potencial antibacteriano do A8 foi avaliado a partir da Concentração Inibitória Mínima (CIM), Concentração Bactericida Mínima (CBM) e Associação pelo método de checkboard. Os valores de CIM e CBM foram de 512 µg/mL para todas as cepas de P. aeruginosa avaliadas, demonstrando atividade predominantemente bactericida. Além disso, quando o A8 foi associado ao fármaco ceftriaxona, evidenciou-se aditividade e indiferença farmacológica. Nesse sentido, a amida sintética se mostrou interessante, pois demonstra potencial para se tornar um possível candidato a fármaco antimicrobiano.

https://doi.org/10.1590/1519-6984.274149

Silicon as an attenuator of the toxic effects of aluminum in Schinus terebinthifolius plants
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Aguilar, M. V. M.

; Mattos, J. P. O.

; Wertonge, G. S.

; Rosa, F. C. R.

; Lovato, L. R.

; Valsoler, D. V.

; Azevedo, T. D.

; Nicoloso, F. T.

; Tabaldi, L. A.

Brazilian Journal of Biology

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2023, Volume 83 elocation e271301

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Aluminum (Al) is highly toxic to plants, since it causes stress and inhibits plant growth. Silicon (Si) is known to mitigate the stress caused by Al in several plant species. Thus, the current study aims to investigate the soothing effects of Si on morphophysiological and photosynthetic variables, and the attributes associated with oxidative stress in Schinus terebinthifolius plants exposed to Al. Treatments have followed a completely randomized design, with three repetitions based on the following Al/Si combinations (in mM): Treatment 1: 0 Al + 0 Si; Treatment 2: 0 Al + 2.5 Si; Treatment 3: 1.85 Al + 0 Si; Treatment 4: 1.85 Al + 2.5 Si; Treatment 5: 3.71 Al + 0 Si; Treatment 6: 3.71 Al + 2.5 Si. Each sampling unit consisted of a tray with 15 plants, totaling forty-five per treatment. Shoot and root morphological variables, photosynthetic variables, photosynthetic pigments, hydrogen peroxide concentration, lipid peroxidation (MDA), guaiacol peroxidase (POD) and superoxide dismutase (SOD) enzymes, and non-enzymatic antioxidant such as Ascorbic acid (AsA) and non-protein thiol (NPSH) concentration were assessed. Root growth inhibition followed by changes in root morphological variables have negatively affected root and shoot biomass production in plants only subjected to Al. However, adding 2.5 mM Si to the treatment has mitigated the toxic effects caused by 1.85 mM of aluminum on S. terebinthifolius plants.

Resumo O alumínio (Al) é altamente tóxico para as plantas, pois causa estresse e inibe o crescimento vegetal. O silício (Si) é conhecido por atenuar o estresse causado pelo Al em diversas espécies vegetais. Assim, o presente estudo tem como objetivo investigar os efeitos suavizantes do Si sobre variáveis morfofisiológicas e fotossintéticas, e os atributos associados ao estresse oxidativo em plantas de Schinus terebinthifolius expostas ao Al. Os tratamentos seguiram um delineamento inteiramente casualizado, com três repetições baseadas nas seguintes combinações Al/Si (em mM): Tratamento 1: 0 Al + 0 Si; Tratamento 2: 0 Al + 2,5 Si; Tratamento 3: 1,85 Al + 0 Si; Tratamento 4: 1,85 Al + 2,5 Si; Tratamento 5: 3,71 Al + 0 Si; Tratamento 6: 3,71 Al + 2,5 Si. Cada unidade amostral constou de uma bandeja com 15 plantas, totalizando quarenta e cinco plantas por tratamento. Variáveis morfológicas da parte aérea e da raiz, variáveis fotossintéticas, pigmentos fotossintéticos, concentração de peróxido de hidrogênio, peroxidação lipídica (MDA), enzimas guaiacol peroxidase (POD) e superóxido dismutase (SOD) e antioxidantes não enzimáticos como ácido ascórbico (AsA) e grupos tiós não protéicos (NPSH) foram avaliadas. A inibição do crescimento radicular seguida de alterações nas variáveis morfológicas radiculares afetaram negativamente a produção de biomassa radicular e aérea em plantas submetidas apenas ao Al. No entanto, a adição de 2,5 mM de Si ao tratamento atenuou os efeitos tóxicos causados por 1,85 mM de alumínio em plantas de S. terebinthifolius.

https://doi.org/10.1590/1519-6984.271301

Cuidados de enfermagem em Endoscopia Brônquica Ultrassónica
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A.P., Mendes

; Rosa, L. M. E. S.

; Paiva, I.

Revista Onconews

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dec 2022, N. 45 elocation e081

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: El objetivo de este artículo de revisión es describir y enmarcar históricamente el uso de la técnica endoscópica en Neumología, las principales indicaciones clínicas para realizar la endoscopia bronquial ultrasónica, las técnicas y equipos utilizados en su ejecución, las complicaciones más frecuentes así como las intervenciones de enfermería. Se utilizó PubMed y SciELO como bases de investigación.

Resumo: Pretende-se com este artigo de revisão descrever e enquadrar historicamente a utilização da técnica endoscópica em Pneumologia, as principais indicações clínicas para a realização de endoscopia brônquica ultrassónica, as técnicas e equipamentos utilizados na sua execução, as complicações mais frequentes bem como as intervenções de enfermagem. Foram utilizadas como bases de pesquisa a PubMed e a SciELO.

Abstract: This review article aims to describe and historically frame the use of endoscopic technique in Pulmonology, the main clinical indications for ultrasonic bronchial endoscopy, the techniques and equipment used in its execution, the most frequent complications as well as nursing interventions. PubMed and SciELO were used as research bases.

https://doi.org/10.31877/on.2022.45.05

10.

Infecciones respiratorias causadas por agentes bacterianos en bovinos y ovinos de la Provincia de Corrientes, Argentina
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Rosa, P. Della

; Sala, J. M.

; Morel, V.

; Gómez, S.

; Caspe, S. G.

Revista veterinaria

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jun 2022, Volume 33 N. 2 Pages 164 - 168

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Mannheimia haemolytica, Trueperella pyogenes and Pasteurella multocida are commensal bacteria of the upper respiratory tract of ruminants. However, in presence of predisposing factors, they can trigger the disease and even lead to death. The objective of this study was to determine the causes of morbidity and mortality in calves and lambs from 4 establishments located in the Province of Corrientes, Argentina. During of the period between June and August 2021, 4 cases of respiratory diseases were received at the INTA Mercedes, Corrientes, Animal Health Laboratory, both in cattle (3) and sheep (1). Incase of cattle, the morbidity in each the herd was 3.3% (5/150), 3.5% (7/200) and 12.4% (56/450). In the sheep flock, the morbidity was 8% (4/50). In sick animals, necropsies were performed and samples of lung and lung abscess were taken. In those samples, bacteriological culture and histological analysis were performed. Bacterial agents including T. pyogenes (1), M. haemolytica (2) and P. multocida (1) were detected, associated with the macroscopic findings and histological lesions. In our study, bacterial agents were detected as causing pneumonia represent in between 2 and 6% of mortality in the herds analyzed, so they should be considered as an important cause of death, in order to implement the necessary corrective and preventive measures.

Resumen Mannheimia haemolytica, Trueperella pyogenes y Pasteurella multocida son bacterias comensales de las vías respiratorias superiores de los rumiantes. Sin embargo, cuando existen factores predisponentes pueden desencadenar enfermedades respiratorias o incluso ocasionar la muerte. El objetivo de este estudio fue determinar las causas de morbilidad y mortalidad en terneros y corderos de 4 establecimientos ubicados en la Provincia de Corrientes, Argentina. Durante los meses de junio a agosto de 2021 se recibieron en el laboratorio de Sanidad Animal del INTA Mercedes, Corrientes, 4 casos de enfermedades respiratorias, tanto en bovinos (3), como en ovinos (1). En el caso de los bovinos, los lotes presentaban una morbilidad de 3,3% (5/150), 3,5% (7/200) y 12,4% (56/450). Por su parte, el lote de ovinos expuestos contó con un 8% (4/50) de animales enfermos. Se realizó la necropsia de los ejemplares, tomando muestras de pulmón y en los casos que estuvieron disponibles, abscesos pulmonares. Con dichas muestras, se realizó el cultivo bacteriológico y análisis histológico. Mediante el cultivo bacteriológico se detectó la acción de T. pyogenes (1), M. haemolytica (2) y P. multocida (1) coincidente con los hallazgos macroscópicos y lesiones histológicas halladas. En nuestro estudio las neumonías por agentes bacterianos representaron entre el 2 y 6% de las causas de mortalidad de los rodeos analizados, por lo que deberían ser tenidas en cuenta como causante de muerte, a fin de implementar las maniobras correctivas y preventivas necesarias.

https://doi.org/10.30972/vet.3326177

11.

Tuberculosis abdominal que mimetiza cáncer de ovario. Reporte de una serie de casos
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Morales-Castelán, Jerson E.

; Lara-Hernández, María E.

; Hernández-Nava, Jarol M.

; Lino-Silva, Leonardo S.

; Salcedo-Hernández, Rosa A.

Gaceta médica de México

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jun 2022, Volume 158 N. 3 Pages 130 - 134

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: La tuberculosis peritoneal (tuberculosis abdominal) puede ser confundida con una neoplasia maligna. Objetivo: Describir características clínicas y demográficas de pacientes con tuberculosis abdominal que semeja cáncer de ovario avanzado, diagnosticados en un centro oncológico de referencia nacional. Métodos: Se describen las características clínicas y patológicas de nueve pacientes con tuberculosis abdominal que clínicamente semejaba cáncer de ovario avanzado Resultados: La mediana de edad fue de 47 años, el estrato socioeconómico más común fue bajo (44 %). El dolor abdominal y la pérdida ponderal se presentaron en 77.7 %, ascitis en 55.5 %, prueba COMBE positiva en 22.2 % y ausencia de antecedente de tuberculosis pulmonar en 100 %. La elevación de CA-125 se reportó en 77.7 %, con > 500 U/mL en 57.1 %. La tomografía indicó carcinomatosis en 50 % y tumor pélvico y ascitis en 37.5 %. Todas las pacientes fueron sometidas a cirugía; 62.5 % fueron diagnosticadas mediante estudio patológico transoperatorio como enfermedad neoplásica Conclusión: La tuberculosis es considerada como la gran imitadora, por ello se debe tener en mente el diagnóstico de tuberculosis abdominal ante un caso sospechoso, aun cuando la presentación clínica, estudios de imagen e, incluso, el examen transoperatorio sugieran cáncer de ovario.

Abstract Introduction: Peritoneal tuberculosis (abdominal tuberculosis) can be confused with a malignant neoplasm. Objective: To describe clinical and demographic characteristics of patients with abdominal tuberculosis mimicking advanced ovarian cancer, diagnosed in a national reference cancer center. Methods: Clinical and pathological characteristics of nine patients with abdominal tuberculosis that clinically resembled advanced ovarian cancer are described. Results: Median age was 47 years; the most common socioeconomic status was low (44%). Abdominal pain and weight loss occurred in 77.7%; ascites, in 55.5%; 22.2% had a positive COMBE test, and 100% had no history of pulmonary tuberculosis. CA-125 elevation was reported in 77.7%, with levels > 500 U/mL in 57.1%. Tomography reported carcinomatosis in 50% and pelvic tumor and ascites in 37.5%. All patients underwent surgery, where 62.5% were diagnosed by intraoperative pathology study as neoplastic disease. Conclusion: Tuberculosis is considered the great imitator, which is why abdominal tuberculosis diagnosis should be borne in mind when faced with a suspicious case, even when clinical presentation, imaging studies, and even intraoperative examination suggest ovarian cancer.

https://doi.org/10.24875/gmm.22000006 28 downloads

12.

REDGIM COMO APLICATIVO DE SMARTPHONE PARA APLICAÇÕES QUIMIOMÉTRICAS POR MEIO DE ANÁLISE DE IMAGENS: UM USO EM PLS
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Rosa, Thalles R.

; Siqueira, Bruno M. M.

; Costa, Rayana A.

; Reis, Jadson Z. dos

; Pacheco, Wagner L. S.

; Moura, Paulo R. G. de

; Romão, Wanderson

; Filgueiras, Paulo R.

Química Nova

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may 2022, Volume 45 N. 5 Pages 550 - 559

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The study of the spectrum of light has increased its range of action in the field of chemistry, with the help of several advanced equipment and innovative techniques that have become a strong ally of analytical chemistry. However, the simplicity of obtaining results integrated with mobile devices appears as an interesting path to be taken in the field of chemical analysis. This work addresses the dissemination of an application called REDGIM for smartphones on the Android platform capable of working with multivariate image analysis using chemometric methods through the luminous intensities of photos and R (red), G (green) and B (blue) channels. In order to show the potential of REDGIM, we propose two applications using the partial least squares (PLS) regression method: 1) quantification of free chlorine in tap water; and 2) quantification of cannabinol, (CBN, a type of cannabinoid) in marijuana and hashish samples. The free chlorine concentration obtained for two investigated samples was 0.73 and 0.74 mg L-1 and 0.74 and 0.76 mg L-1 by the spectrophotometer and by the application (container: cuvette), respectively. For the quantification of CBN in marijuana and hashish samples, the mean concentration ranged from 6.137 to 8.823 mg mL-1. The results obtained by the application are compatible with results from traditional techniques, such as UV-Vis spectrophotometry, for example. Therefore, REDGIM was proved to be a simple and accessible technological tool for the scientific community, being viable for chemical tests of a multivariate nature.

https://doi.org/10.21577/0100-4042.20170861

13.

Doxazosin adsorption in natural, expanded, and organophilized vermiculite-rich clays
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Rosa, M. S. L.

; Silva, R. A. O.

; Sousa, P. A. A. e

; Nascimento, R. T. do

; Knoerzer, T.

; Santos, M. R. M. C.

Cerâmica

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mar 2022, Volume 68 N. 385 Pages 75 - 83

Abstract: En | Text: En | PDF: En

Abstract Vermiculite clays are adsorbent materials that have good chemical adsorption capacity, which makes them applicable in the removal of drugs from aqueous solutions. Their lamellar structure can be easily expanded and organophilized. To assess the efficacy and environmentally-tolerant capacity of the adsorption method, the organophilized vermiculite clay was compared to both natural and expanded vermiculite clays. To prepare the organophilized clays, a natural clay sample was expanded at 900 °C. The expanded clay was thus treated by immersion in a 1.0 M NaCl solution and organophilized using a cetyltrimethylammonium bromide (CTMA-Br) surfactant, for 24 h at 50 °C. Natural, expanded, and organophilized samples were characterized using the techniques of XRD, FTIR, TG/DSC, and SEM to observe structural changes after expansion and organophilization. These characterizations indicated that there was an increase in the interlamellar space of the expanded and organophilized sample. In addition, a study of the point of zero charge was performed to determine the surface changes of the samples and the amount of doxazosin adsorption in the samples was determined by the time adsorption test. Further, the organophilized sample showed potential adsorption of the drug doxazosin and high performance in relation to the expanded and natural samples.

https://doi.org/10.1590/0366-69132022683853175

14.

Glacial meltwater input to the ocean around the Antarctic Peninsula: forcings and consequences
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LIMA, LUCIANA S.

; PEZZI, LUCIANO P.

; MATA, MAURÍCIO M.

; SANTINI, MARCELO F.

; CARVALHO, JONAS T.

; SUTIL, UESLEI ADRIANO

; CABRERA, MYLENE J.

; ROSA, ELIANA B.

; RODRIGUES, CELINA C.F.

; VEGA, XIMENA A.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Suppl. 1 elocation e20210811

Abstract: En | Text: En | PDF: En

Abstract The Antarctic region has experienced recent climate and environmental variations due to climate change, such as ice sheets and ice shelves loss, and changes in the production, extension, and thickness of sea-ice. These processes mainly affect the freshwater supply to the Southern Ocean and its water masses formation and export, being crucial to changes in the global climate. Here, we review the influence of the glacial freshwater input on the Antarctic Peninsula adjacent ocean. We highlight each climate process’ relevance on freshwater contribution to the sea and present a current overview of how these processes are being addressed and studied. The increase of freshwater input into the ocean carries several implications on climate, regionally and globally. Due to glacier melting, the intrusion of colder and lighter water into the ocean increases the stratification of the water column, influencing the sea-ice increase and reducing ocean-atmosphere exchanges, affecting the global water cycle. This study shows the role of each hydrological cycle processes and their contributions to the regional oceanography and potentially to climate.

https://doi.org/10.1590/0001-3765202220210811

15.

Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
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Bensenor, Isabela M.

; Goulart, Alessandra C.

; Pereira, Alexandre C.

; Brunoni, André R.

; Alencar, Airlane

; Santos, Raul D.

; Bittencourt, Márcio S.

; Telles, Rosa W.

; Machado, Luciana Andrade Carneiro

; Barreto, Sandhi Maria

; de Almeida-Pititto, Bianca

; Janovsky, Carolina Porto Silva

; Sgarbi, José Augusto

; Tebar, William R.

; Meneghini, Vandrize

; Barbosa Junior, Fernando

; Ribeiro, Ana Cristina de Medeiros

; Pasoto, Sandra Gofinet

; Pereira, Rosa Maria R.

; Bonfá, Eloísa

; Sipahi, Aytan M.

; Santos, Itamar de S.

; Lotufo, Paulo A.

Clinics

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2022, Volume 77 elocation 100013

Abstract: En | Text: En | PDF: En

Abstract Objectives This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.

https://doi.org/10.1016/j.clinsp.2022.100013

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