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au:SALGADO, JOAO VINICIUS

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Validation of the Brazilian version of the Hinting Task and Facial Emotion Recognition Test (FERT-100) in patients with schizophrenia
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Cruz, Breno Fiuza

; Oliveira, Amanda Margarida de

; Del-Ben, Cristina Marta

; Corcoran, Rhiannon

; Salgado, João Vinícius

Dementia & Neuropsychologia

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sep 2022, Volume 16 N. 3 Pages 300 - 308

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A cognição social é um domínio especialmente relevante na esquizofrenia devido à sua associação com o comprometimento funcional. No entanto, ainda não temos estudos que validaram instrumentos com qualidades psicométricas internacionalmente estabelecidas para a população brasileira. Objetivos: Apresentar as qualidades psicométricas e contribuir para a validação da versão brasileira do Hinting Task e do Teste de Reconhecimento de Emoções Faciais (FERT-100). Métodos: Foram avaliados 104 pacientes estabilizados residentes na comunidade com diagnóstico de esquizofrenia e 89 controles. Avaliou-se as propriedades psicométricas do Hinting Task e FERT-100 para validade de construto discriminante, validade de construto divergente, validade de construto convergente, validade de critério concorrente e confiabilidade. Resultados: Houve uma diferença estatisticamente significativa entre pacientes e controles quanto à cognição social (Hinting Task: Z=6,85; p<0,001. FERT-100: t=4,88; p<0,001). Os principais preditores da variação na cognição social foram os domínios neurocognitivos. As associações entre os testes de cognição social e outras variáveis estudadas são semelhantes às encontradas na literatura. A cognição social mantém correlação com a capacidade funcional mesmo quando a neurocognição é levada em consideração. Conclusões: A validade da versão brasileira do Hinting Task e do FERT-100 pode ser determinada, pois a relação desses testes com outras variáveis clínicas é semelhante à observada na literatura.

ABSTRACT Social cognition is an especially relevant domain in schizophrenia due to its association with functional impairment. However, we still do not have studies that have validated instruments with internationally established psychometric qualities for the Brazilian population. Objectives: This study aimed to present psychometric qualities and contribute to the validation of the Brazilian version of the Hinting Task and Facial Emotion Recognition Test (FERT-100). Methods: A total of 104 stabilized patients living in the community diagnosed with schizophrenia and 89 controls were evaluated. We assess the psychometric properties of Hinting Task and FERT-100 for discriminant construct validity, divergent construct validity, convergent construct validity, concurrent criterion validity, and reliability. Results: There is a statistically significant difference between patients and controls regarding social cognition (Hinting Task: Z=6.85, p<0.001; FERT-100: t=4.88, p<0.001). The main predictors of variation in social cognition were the neurocognitive domains. The associations between social cognition tests and other studied variables are similar to what is found in the literature. Social cognition maintains correlation with functional capacity even when neurocognition is taken into account. Conclusions: The validity of the Brazilian version of Hinting Task and FERT-100 can be determined, since the relationship of these tests with other clinical variables is similar to that observed in the literature.

https://doi.org/10.1590/1980-5764-dn-2021-0108

Two years of the COVID-19 pandemic: an anesthesiology perspective
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Schmidt, André P.

; Módolo, Norma S.P.

; de Amorim, Célio G.

; Simões, Cláudia M.

; Kraychete, Durval C.

; Joaquim, Eduardo H.G.

; Lineburger, Eric B.

; Papa, Fábio V.

; Fernandes, Fátima C.

; Mendes, Florentino F.

; Guimarães, Gabriel M.N.

; Barros, Guilherme A.M.

; Silva-Jr, João M.

; Lima, Laís H. Navarro e

; Azi, Liana M.T.A.

; Carvalho, Lorena I.M.

; Stefani, Luciana C.

; Garcia, Luis V.

; Carmona, Maria José C.

; Salgado Filho, Marcello F.

; Nascimento Junior, Paulo do

; Alves, Rodrigo L.

; Carvalho, Vanessa H.

; Quintão, Vinicius C.

; Carmona, Maria José C.

Brazilian Journal of Anesthesiology

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apr 2022, Volume 72 N. 2 Pages 165 - 168

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.bjane.2022.02.004

Childhood trauma is associated with age at onset of symptoms, functioning, and cognition in patients with schizophrenia
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De-Nardin, Emmanuely Macedo Santana

; Muratori, Camilla Alves

; Ribeiro, Isabela Serra

; Huguet, Rodrigo Barreto

; Salgado, Joao Vinicius

Trends in Psychiatry and Psychotherapy

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2022, Volume 44 elocation e20190081

Abstract: En | Text: En | PDF: En

Abstract Introduction Childhood trauma (CT) is known to be a vulnerability factor for schizophrenia, but the specific impacts of different trauma subtypes on the prognosis of these patients remains unclear. Objective To assess the relationships between the occurrence of overall CT and its subtypes with factors with known prognostic impact on schizophrenia, such as age at onset of symptoms, global functioning, and cognitive impairment in a sample of Brazilian patients. Methods One hundred and five stable patients diagnosed with schizophrenia according to DSM-5 criteria were evaluated using the Independent Living Skills Survey (ILSS; self-report global functioning), Schizophrenia Cognition Rating Scale (SCoRS; subjective cognitive impairment), and Childhood Trauma Questionnaire scales (CTQ; perceived overall CT, emotional neglect, physical neglect, physical abuse, and emotional and sexual abuse). Statistical analysis was performed with multivariate linear regression. Results After controlling for educational level and age, subjective cognitive impairment was directly correlated with overall perceived CT occurrence, emotional abuse, and sexual abuse. Self-report global functioning was inversely correlated with perceived overall CT occurrence, emotional abuse, and sexual abuse. Emotional abuse and physical abuse were also inversely correlated with age at onset of symptoms. Conclusions CT can be related to more severe prognoses in schizophrenia, impacting on early onset of symptoms, lower global functioning, and greater cognitive impairment. Subtypes of trauma can be associated with different prognostic risks.

https://doi.org/10.47626/2237-6089-2019-0081

Characterization of neurological soft signs in a Brazilian sample of stable patients with schizophrenia
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Pedroso, Vinicius Sousa Pietra

; Teixeira, Antônio Lúcio

; Salgado, João Vinícius

Trends in Psychiatry and Psychotherapy

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sep 2018, Volume 40 N. 3 Pages 244 - 247

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Sinais neurológicos sutis (SNS) têm sido considerados características básicas e potenciais endofenótipos na esquizofrenia. O presente estudo procurou caracterizar os SNS em uma amostra de pacientes com esquizofrenia crônica e compará-los com indivíduos controles saudáveis. Métodos: Neste estudo, avaliamos a presença de SNS em uma amostra de pacientes estáveis (n = 24) com o diagnóstico de esquizofrenia de acordo com os critérios do DSM-IV, recrutados no Ambulatório de Esquizofrenia do Instituto Raul Soares, Belo Horizonte, MG, Brasil. A avaliação foi realizada com a Escala Motora Breve (BMS) e sinais extrapiramidais (SEP) foram observados com a Escala de Simpson-Angus (SAS) e a Escala de Movimentos Involuntários Anormais (AIMS). Um grupo controle (n = 21) também foi submetido à mesma bateria de testes. Resultados: Observamos uma diferença significativa em relação aos escores da BMS e da SAS (p < 0,0001), revelando que indivíduos com esquizofrenia apresentam mais SNS e SEP que indivíduos saudáveis. Os escores da BMS se correlacionaram positivamente com os da SAS (r = 0,495, p = 0,014), mas não com os da AIMS, indicando que os SNS podem ser influenciados pela intensidade de SEP. No entanto, observamos que essa relação permaneceu somente para as tarefas de coordenação motora (r = 0,550, p = 0,005), enquanto as tarefas de sequenciamento motor não foram influenciadas pelos SEP (r = 0,313, p = 0,136). Conclusão: Os resultados sugerem que os SNS são mais frequentes em pacientes com esquizofrenia e que tarefas de sequenciamento motor podem ser mais específicas na síndrome.

Abstract Introduction: Neurological soft signs (NSS) have been considered one of the target features and a potential endophenotype for schizophrenia. The present study aimed to characterize NSS in a sample of patients with chronic schizophrenia and to compare them with healthy control individuals. Methods: In this study, we evaluated the presence of NSS in a sample of stable patients (n = 24) diagnosed with schizophrenia according to DSM-IV criteria, recruited at the Schizophrenia Outpatient Clinic of Instituto Raul Soares, Belo Horizonte, state of Minas Gerais, southeastern Brazil. Assessment was made with the Brief Motor Scale (BMS), and extrapyramidal symptoms (EPS) were evaluated with the Simpson-Angus Scale (SAS) and the Abnormal Involuntary Movement Scale (AIMS). A control group (n = 21) was also submitted to the same battery of tests. Results: We observed a significant difference in relation to BMS and SAS scores (p < 0.0001), revealing that individuals with schizophrenia present more NSS and EPS than healthy ones. BMS total scores correlated positively with SAS scores (r = 0.495, p = 0.014), but not with AIMS scores, indicating that NSS could be influenced by the intensity of EPS. Nevertheless, we observed that this relationship remained only for motor coordination tasks (r = 0.550, p = 0.005), while motor sequencing tasks were not influenced by EPS (r = 0.313, p = 0.136). Conclusion: The results suggest that NSS are more frequent in patients with schizophrenia and that motor sequencing tasks could be more specific to the syndrome.

https://doi.org/10.1590/2237-6089-2017-0090 995 downloads

Capgras syndrome in a first-episode, late-onset and super-refractory schizophrenia case
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Junho, Bruno T.

; Pena, Roberta R.

; Salgado, João Vinícius

; Mantovani, Lucas M.

Archives of Clinical Psychiatry (São Paulo)

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may 2018, Volume 45 N. 3 Pages 77 - 77

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0101-60830000000162 1178 downloads

Toxoplasma gondii infection and chronic schizophrenia: is there any association?
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Campos-Carli, Salvina Maria de

; Vieira, Érica Leandro Marciano

; Rocha, Natalia Pessoa

; Oliveira, Keliane de

; Guimarães, Fernanda Carneiro

; Barbosa, Izabela Guimarães

; Barros, João Luís Vieira Monteiro de

; Okusaga, Olaoluwa

; Martins-Filho, Olindo Assis

; Salgado, João Vinícius

; Teixeira, Antônio Lúcio

Archives of Clinical Psychiatry (São Paulo)

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dec 2017, Volume 44 N. 6 Pages 145 - 148

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Toxoplasma gondii (T. gondii) infection has been identified as a risk factor for schizophrenia. Objectives: Herein, we sought to evaluate the association between T. gondii infection and clinical symptoms and quality of life in patients with schizophrenia. Methods: We conducted a cross-sectional study with 48 patients with chronic schizophrenia and 40 controls. Peripheral blood was drawn, and IgM and IgG anti-T. gondii antibodies were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). Depressive, positive and negative symptoms were assessed, respectively, by the Calgary Depression Scale (CDS) and the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed in patients by the Brazilian version of the Schizophrenia Cognition Rating Scale (SCoRS-BR). Quality of life was assessed by the Brazilian version of the Quality of Life in Schizophrenia scale (QLS-BR). Results: The prevalence and titers of T. gondii IgM and IgG antibodies did not differ between patients and controls. The positive serology for T. gondii IgG antibodies was not associated with illness symptoms, cognitive performance, depressive symptoms or quality of life. Discussion: Our findings suggest that toxoplasmosis infection is not associated with severity of symptoms, quality of life, cognitive or depressive symptoms in schizophrenia patients.

https://doi.org/10.1590/0101-60830000000140 2009 downloads

Tradução e adaptação cultural para o português brasileiro da Cambridge Depersonalisation Scale (Escala de Despersonalização de Cambridge)
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Salgado, Ana Carolina Sarquis

; Souza, Leonardo Cruz de

; Salgado, João Vinícius

; Sierra, Mauricio

; Teixeira, Antônio Lúcio

Jornal Brasileiro de Psiquiatria

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dec 2016, Volume 65 N. 4 Pages 330 - 333

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Realizar a tradução e a adaptação cultural da Escala de Despersonalização de Cambridge (EDC) para o português brasileiro. Métodos Foi realizada a tradução da escala em duas versões, seguida por retrotradução por nativo de língua inglesa. Os itens da escala foram comparados e adaptados para o contexto brasileiro e, então, transformados em uma versão-teste, que foi aplicada em 30 participantes sem diagnóstico de transtorno psiquiátrico. Resultados A versão em português da EDC mostrou boa compreensibilidade. A maior parte dos participantes relatou experiências transitórias ligadas à despersonalização nos últimos seis meses (53,3% dos casos), incluindo a sensação de ser um observador externo de si mesmo (35%) e sensação de estar fora do corpo (10%). Conclusões O presente estudo confirma a alta frequência de experiências de despersonalização. Serão necessários estudos para verificação das propriedades psicométricas da escala.

ABSTRACT Objective To perform the translation and cultural adaptation of the Cambridge Depersonalization Scale (CDS) to Brazilian Portuguese. Methods The scale translation was performed in two versions, followed by back translation by a native English speaker. Scale items were compared and adapted to the Brazilian context, and then transformed into a test version, applied to 30 participants without diagnosis of psychiatric disorders. Results The Portuguese version of the CDS showed good comprehensibility. Most participants reported depersonalization transient experiences over the last six months (53.3% of the cases), including feeling of being an outside observer of the self (35%) and feeling of being outside the body (10%). Conclusions The current study confirms the high frequency of depersonalization experiences. Further studies are needed to verify the psychometric properties of the scale.

https://doi.org/10.1590/0047-2085000000141 4253 downloads

Family burden in schizophrenia: the influence of age of onset and negative symptoms
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Mantovani, Lucas M.

; Ferretjans, Rodrigo

; Marçal, Iara M.

; Oliveira, Amanda M.

; Guimarães, Fernanda C.

; Salgado, João Vinícius

Trends in Psychiatry and Psychotherapy

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jun 2016, Volume 38 N. 2 Pages 96 - 99

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Investigar os determinantes de sobrecarga familiar numa amostra de pacientes com esquizofrenia e seus cuidadores. Métodos: Trinta e um pacientes com esquizofrenia e seus principais cuidadores participaram do estudo. Variáveis sociodemográficas foram analisadas por meio de uma entrevista semiestruturada, e sintomas positivos e negativos foram quantificados através da Positive and Negative Syndrome Scale (PANSS). O desempenho cognitivo foi mensurado pela Schizophrenia Cognition Rating Scale (SCoRS). A Escala de Avaliação da Sobrecarga dos Familiares (FBIS) avaliou os níveis de sobrecarga entre os cuidadores. As interações entre as variáveis foram verificadas por meio do coeficiente de correlação de Pearson e de análise de regressão linear. Resultados: Os escores objetivos e subjetivos da FBIS foram 1,9 [desvio padrão (DP) 0,5] e 2,4 (DP 0,6), respectivamente. Sobrecarga objetiva se correlacionou positivamente com sintomas positivos e negativos, e com prejuízos cognitivos. A sobrecarga subjetiva se correlacionou positivamente com sintomas positivos, e negativamente com a idade de início da doença. Os sintomas positivos e negativos e os prejuízos cognitivos contribuíram com 47,6% da variância da sobrecarga objetiva, sendo que sintomas negativos foram responsáveis independentemente por 30,3%. A idade de início da doença, os pais na posição de cuidadores e os sintomas positivos contribuíram com 28% da variância da sobrecarga subjetiva, sendo que a idade de início da doença contribuiu independentemente com 20,3%. Conclusões: Variáveis sociodemográficas e clínicas dos pacientes são importantes determinantes de sobrecarga familiar na esquizofrenia. A sobrecarga objetiva pode ser predita por sintomas, especialmente os negativos. A sobrecarga subjetiva pode ser predita por sintomas e características sociodemográficas, particularmente a idade de início da doença.

Abstract Objectives: To investigate the determinants of family burden in a sample of patients with schizophrenia and their caregivers. Methods: Thirty-one stable patients with schizophrenia and their main caregivers were recruited. Sociodemographic variables were assessed in a semi-structured interview, and positive and negative symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Cognitive performance was assessed with the Schizophrenia Cognition Rating Scale (SCoRS). Levels of burden on caregivers were assessed with the Family Burden Interview Schedule (FBIS). Interactions among variables were analyzed using Pearson correlations and linear regression analysis. Results: Objective and subjective FBIS scores were 1.9 (standard deviation [SD] = 0.5) and 2.4 (SD = 0.6) respectively. Objective burden correlated positively with positive and negative symptoms, and cognitive impairment. Subjective burden correlated positively with positive symptoms and negatively with mean age of disease onset. Positive, negative and cognitive symptoms accounted for 47.6% of the variance of objective burden, with negative symptoms accounting independently for 30.3%. Age of onset, parents as caregivers and positive symptoms accounted for 28% of the variance of subjective burden, with age of onset independently explaining 20.3%. Conclusion: Patients' clinical and sociodemographic variables are important determinants of family burden in schizophrenia. Objective burden is predicted by symptoms, particularly negative ones. Subjective burden is predicted by symptoms and sociodemographic variables, particularly age of disease onset.

https://doi.org/10.1590/2237-6089-2015-0082 3032 downloads

Validity and reliability of the Brazilian Portuguese version of the BACS (Brief Assessment of Cognition in Schizophrenia)
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Araújo, Geovany Eliberto

; Resende, Camilo Brandão de

; Cardoso, Ana Cecília Alves

; Teixeira, Antonio Lúcio

; Keefe, Richard S.E.

; Salgado, João Vinícius

Clinics

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apr 2015, Volume 70 N. 4 Pages 278 - 282

Abstract: En | Text: En | PDF: En

OBJECTIVE: To assess the validity and reliability of the Brazilian Portuguese version of the Brief Assessment of Cognition in Schizophrenia by examining its temporal stability, internal consistency, and discriminant and convergent validity. METHODS: The Brief Assessment of Cognition in Schizophrenia was administered to 116 stable patients with schizophrenia and 58 matched control subjects. To assess concurrent validity, a subset of patients underwent a traditional neuropsychological assessment. RESULTS: The patients with schizophrenia performed significantly worse than the controls (p<0.001) on all subtests of the Brief Assessment of Cognition in Schizophrenia and on the total score, which attests to the discriminant validity of the test. The global score of the Brief Assessment of Cognition in Schizophrenia was significantly correlated with all of the subtests and with the global score for the standard battery. The Brief Assessment of Cognition in Schizophrenia also had good test-retest reliability (rho>0.8). The internal consistency of the Brief Assessment of Cognition in Schizophrenia was high (Cronbach's α ϝ 0.874). CONCLUSION: The Brazilian Portuguese version of the Brief Assessment of Cognition in Schizophrenia exhibits good reliability and discriminant and concurrent validity and is a promising tool for easily assessing cognitive impairment in schizophrenia and for comparing the performance of Brazilian patients with that of patients from other countries.

https://doi.org/10.6061/clinics/2015(04)10 1481 downloads

10.

A critical overview of animal models of psychiatric disorders: challenges and perspectives
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Salgado, Joao Vinicius

; Sandner, Guy

Brazilian Journal of Psychiatry

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2013, Volume 35 Suppl. 2 Pages S77 - S81

Abstract: En | Text: En | PDF: En

Animal models of psychiatric disorders are a challenging but highly relevant issue. Most psychiatric disorders are very heterogeneous syndromes, resulting from multiple and varied causal factors and characterized by symptoms that can only be inferred with significant limitations in non-human models. As constructing a model that reproduces a whole psychiatric syndrome seems virtually impossible, researchers have tried to focus on endophenotypes, i.e., discrete traits that are more proximal to predisposing genes than the whole syndrome. These can be explored in a wide range of approaches, such as in pharmacological, lesion, and environmental models. Another challenge is to understand how genes interact with environmental factors over time to result in the syndromic phenotype. A better understanding of the subcellular mechanisms that enhance or allow brain resistance to environmental influences is required, as is a global thesis compatible with the diversity of diseases sharing similar behavioral and biological traits. With an experimental inventory of the possible causes of minor developmental failures, we may systematically explore their consequences in the adult animal and be able to decide if this will enlighten the understanding of one or another psychiatric disease.

https://doi.org/10.1590/1516-4446-2013-1156 6120 downloads Cited 2 times in SciELO

11.

George Harrison's inner light
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Oliveira, Guilherme Nogueira M de

; Salgado, João Vinícius

; Barbosa, Izabela Guimarães

; Teixeira, Antônio Lúcio

Brazilian Journal of Psychiatry

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dec 2012, Volume 34 N. 4 Pages 517 - 518

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.rbp.2012.10.001 1826 downloads

12.

Depersonalization and derealization syndrome: report on a case study and pharmacological management
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Salgado, Ana

; Oliveira, Leonardo

; Sierra-Siegert, Mauricio

; Salgado, João Vinicius

Brazilian Journal of Psychiatry

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dec 2012, Volume 34 N. 4 Pages 505 - 506

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.rbp.2012.04.006 31498 downloads

13.

Applicability of the Rey Auditory-Verbal Learning Test to an adult sample in Brazil
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Salgado, João Vinícius

; Malloy-Diniz, Leandro Fernandes

; Abrantes, Suzana Silva Costa

; Moreira, Lafaiete

; Schlottfeldt, Carlos Guilherme

; Guimarães, Wanderlane

; Freitas, Djeane Marcely Ugoline

; Oliveira, Juliana

; Fuentes, Daniel

Brazilian Journal of Psychiatry

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sep 2011, Volume 33 N. 3 Pages 234 - 237

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: O Rey Auditory-Verbal Learning Test é um teste mundialmente reconhecido na literatura neuropsicológica que avalia o aprendizado e a memória. Na sequência de um estudo anterior, que apresentou o desempenho dos idosos brasileiros no Rey Auditory-Verbal Learning Test, este trabalho apresenta o desempenho dos adultos brasileiros no Rey Auditory-Verbal Learning Test. MÉTODO: Uma versão do teste foi desenvolvida com uma lista de alta frequência, com uma ou duas sílabas de substantivos concretos do português do Brasil. Duzentos e quarenta e três (243) indivíduos de ambos os sexos foram alocados para seis faixas etárias (20-24, 25-29, 30-34, 35-44, 45-54 e 55-60 anos) e avaliados com o Rey Auditory-Verbal Learning Test. RESULTADOS: O grau de escolaridade e idade mostrou correlação positiva e negativa, respectivamente, com o desempenho no Rey Auditory-Verbal Learning Test. As mulheres tiveram um desempenho significativamente melhor que os homens. Os resultados foram semelhantes aos encontrados para a versão em inglês do Rey Auditory-Verbal Learning Test, por meio de faixas etárias semelhantes. CONCLUSÃO: Nossos resultados sugerem que a adaptação do Rey Auditory-Verbal Learning Test para o português brasileiro é adequada e aplicável para avaliação da capacidade de memória de indivíduos brasileiros, com idade similar e educacionais níveis.

OBJECTIVE: The Rey Auditory-Verbal Learning Test, which is used to evaluate learning and memory, is a widely recognized tool in the general literature on neuropsychology. This paper aims at presenting the performance of Brazilian adult subjects on the Rey Auditory-Verbal Learning Test, and was written after we published a previous study on the performance of Brazilian elderly subjects on this same test. METHOD: A version of the test, featuring a list of high-frequency one-syllable and two-syllable concrete Portuguese substantives, was developed. Two hundred and forty-three (243) subjects from both genders were allocated to 6 different age groups (20-24; 25-29; 30-34; 35-44; 45-54 and 55-60 years old). They were then tested using the Rey Auditory-Verbal Learning Test. RESULTS: Performance on the Rey Auditory-Verbal Learning Test showed a positive correlation with educational level and a negative correlation with age. Women performed significantly better than men. When applied across similar age ranges, our results were similar to those recorded for the English version of the Rey Auditory-Verbal Learning Test. CONCLUSION: Our results suggest that the adaptation of the Rey Auditory-Verbal Learning Test to Brazilian Portuguese is appropriate and that it is applicable to Brazilian subjects for memory capacity evaluation purposes and across similar age groups and educational levels.

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14.

Inventário de Depressão em Transtornos Neurológicos para a Epilepsia (IDTN-E): versão brasileira de um instrumento de rastreamento
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Oliveira, Guilherme Nogueira Mendes de

; Araújo Filho, Gerardo Maria de

; Kummer, Arthur

; Salgado, João Vinícius

; Portela, Eduardo Jardel

; Sousa-Pereira, Sílvio Roberto

; Teixeira, Antônio Lúcio

Journal of Epilepsy and Clinical Neurophysiology

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2011, Volume 17 N. 2 Pages 49 - 53

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

INTRODUÇÃO: Depressão é a comorbidade psiquiátrica mais frequente na epilepsia, sendo sua identificação frequentemente negligenciada nos centros especializados. OBJETIVO: Avaliar o desempenho da versão brasileira do Inventário de Depressão em Transtornos Neurológicos para a Epilepsia (IDTN-E) em um grupo de pacientes atendidos em um serviço especializado. MÉTODOS: A versão brasileira do ITDN-E foi aplicada em um grupo de 142 pacientes com epilepsia. Foi utilizado o MINI-Plus como padrão ouro para o diagnóstico de episódio depressivo maior. Resultados: Quarenta pacientes (28,2%) apresentavam o diagnóstico de depressão no momento da avaliação. A análise da curva ROC indicou que o ponto de corte em 15 (>15) para o IDTN-E representa dicotomização ótima entre deprimidos e não deprimidos (sensibilidade de 70,0%, especificidade de 87,3%, valor preditivo positivo de 68,3% e valor preditivo negativo de 88,1%). A utilização de pontos de corte inferiores pode eventualmente ser adotada para proporcionar uma maior sensibilidade ao instrumento. CONCLUSÃO: A versão brasileira do IDTN-E é um instrumento sensível e prático que pode auxiliar o rastreamento da depressão na epilepsia, diminuindo o seu subdiagnóstico.

INTRODUCTION: Depression is the most common psychiatric comorbidity in epilepsy, being its identification frequently neglected in most epilepsy centers. OBJECTIVE: To evaluate the performance of the Brazilian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) in a group of patients from a specialized center. METHODS: The recently validated Brazilian version of the NDDI-E was applied to a group of 142 outpatients with epilepsy. We used the MINI-Plus as a gold standard to diagnosis major depressive episode. Results: Forty patients (28.2%) were depressed at the time of evaluation. The ROC curve analysis indicated that the cutoff at 15 (>15) represented the greatest dichotomy between depressed and nondepressed (sensitivity 70.0%, specificity of 87.3%, positive predictive value of 68.3% and negative predictive value of 88.1%). The use of lower cutoff points may eventually be adopted to provide greater sensitivity to the instrument. CONCLUSION: The Brazilian version of NDDI-E is a sensitive and practical tool that can help in tracking depression in epilepsy in order to reduce its underdiagnosis.

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15.

Inventário de Depressão de Beck (BDI) e Escala de Avaliação de Depressão de Hamilton (HAM-D) em pacientes com epilepsia
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Oliveira, Guilherme Nogueira M. de

; Araujo Filho, Gerardo Maria de

; Kummer, Arthur

; Salgado, João Vinícius

; Portela, Eduardo Jardel

; Sousa-Pereira, Sílvio Roberto

; Teixeira, Antônio Lucio

Jornal Brasileiro de Psiquiatria

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2011, Volume 60 N. 2 Pages 131 - 134

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Determinar os pontos de melhor sensibilidade e especificidade do Inventário de Depressão de Beck (BDI) e da Escala de Avaliação de Depressão de Hamilton (HAM-D) no diagnóstico de depressão associada à epilepsia. MÉTODOS: Setenta e três pacientes de um centro de referência no tratamento da epilepsia foram submetidos à avaliação neuropsiquiátrica. Foram colhidos dados clínicos e sociodemográficos, sendo utilizados os seguintes instrumentos: entrevista clínica estruturada (MINI-PLUS) para diagnóstico psiquiátrico conforme o DSM-IV, HAM-D e BDI. RESULTADOS: No momento da entrevista, 27,4% dos pacientes estavam deprimidos e 37% preenchiam critérios para diagnóstico de depressão maior ao longo da vida. A análise da curva ROC indicou que o ponto de corte em 16 (> 16) para o BDI (sensibilidade de 94,4%, especificidade de 90,6%) e em 16 (> 16) para a HAM-D (sensibilidade de 95%, especificidade de 75,5%) representou dicotomização ótima entre deprimidos e não deprimidos. Ambos os instrumentos apresentaram um valor preditivo negativo superior a 95%. CONCLUSÃO: A frequência de depressão maior é elevada em pacientes com epilepsia. BDI e a HAM-D podem auxiliar o clínico na identificação da depressão associada à epilepsia, diminuindo seu subdiagnóstico.

OBJECTIVE: To determine cutoff points of highest sensitivity and specificity on the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HAM-D) for depression diagnosis in epilepsy. METHODS: Seventy-three patients from a referral center for the treatment of epilepsy underwent neuropsychiatric evaluation. We collected clinical and socio-demographic data, and applied the following instruments: Structured Clinical Interview (MINI-PLUS) for psychiatric diagnosis according to DSM-IV, HAM-D and BDI. RESULTS: At assessment, 27.4% of the patients were depressed and 37% met diagnostic criteria for lifetime major depression. The ROC curve analysis indicated that a score > 16 on the BDI (94.4% sensitivity, 90.6% specificity) and > 16 on the HAM-D (95% sensitivity, 75.5% specificity) revealed great dichotomy between depressed and nondepressed patients. Both instruments showed a negative predictive value exceeding 95%. CONCLUSION: The frequency of major depression is elevated in patients with epilepsy. BDI and HAM-D can help physicians in the identification of depression in epilepsy, reducing its underdiagnosis.

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