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Abstract Introduction: The association of diabetes with subclinical thyroid diseases may increase the risk of cardiovascular diseases. We analyzed the association of subclinical hypothyroidism, diabetes, and both diseases with carotid Intima-Media Thickness (cIMT) as a surrogate maker for early cardiovascular disease in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: Cross-sectional analysis with data from the 3rd visit (2017‒2019). Linear regression models were used to evaluate the association of subclinical hypothyroidism, diabetes and of both diseases with a cIMT presented as Beta (95% Confidence Interval – 95% CI) without adjustment, with adjustment for sociodemographic variables (Model 1) and multivariable adjustment (Model 1 more cardiovascular risk factors). We also used logistic regression models to analyze the Odds Ratio (OR) and 95% CI for the association of both diseases using cIMT > P75%. Results: After the exclusion of patients with previous cardiovascular disease, 5,077 participants with no diseases, 1578 with diabetes, 662 with subclinical hypothyroidism, and 234 with both diseases were included in the analysis. Linear regression models showed an association of cIMT with only diabetes (β = 0.019; 95% CI 0.012 to 0.027; p < 0.0001) and subclinical hypothyroidism more diabetes (β = 0.03; 95% CI 0.010‒0.047, p < 0.0001). The logistic regression model reported an association between diabetes and CIMT higher than P75% (OR = 1.49, 95% CI 1.30‒1.71). No interaction between diabetes and subclinical hypothyroidism was detected using cIMT respectively as a continuous (p = 0.29) or as a categorical variable (p = 0.92). Discussion: Diabetes was associated with higher cIMT values. However, no additive effect of subclinical hypothyroidism associated with diabetes over cIMT was detected.

https://doi.org/10.1016/j.clinsp.2022.100154

Antioxidants and cardioprotective effects of ethyl acetate fraction of Canavalia rosea leaves in myocardial ischemia-reperfusion injury
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FEITOSA, MARAÍSA B.J.

; ARAÚJO, SILVAN S.

; MESQUITA, THÁSSIO RICARDO R.

; GIODA, CAROLINA R.

; SÁ, LUCAS A. DE

; ALMEIDA, GRACE KELLY M.

; MIGUEL-DOS-SANTOS, RODRIGO

; BARBOSA, ANDRIELE M.

; VASCONCELOS, CARLA MARIA L. DE

; CAMARGO, ENILTON A.

; BARREIROS, ANDRÉ LUÍS B.S.

; ESTEVAM, CHARLES S.

; MORAES, ÉDER RICARDO DE

; AMARAL, RICARDO G.

; LAUTON-SANTOS, SANDRA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Suppl. 1 elocation e20220514

Abstract: En | Text: En | PDF: En

Abstract Different degrees in the biological activities of Canavalia rosea had been previously reported . In this study, our group assessed the cardioprotective effects of the ethyl acetate fraction (EAcF) of the Canavalia rosea leaves. Firstly, it was confirmed, by in vitro approach, that the EAcF has high antioxidant properties due to the presence of important secondary metabolites, as flavonoids. In order to explore their potential protector against cardiovascular disorders, hearts were previously perfused with EAcF (300 μg.mL-1) and submitted to the global ischemia followed by reperfusion in Langendorff system. The present findings have demonstrated that EAcF restored the left ventricular developed pressure and decreased the arrhythmias severity index. Furthermore, EAcF significantly increased the glutathiones peroxidase activity with decreased malondialdehyde and creatine kinase levels. EAcF was effective upon neither the superoxide dismutase, glutationes reductase nor the catalase activities. In addition, the Western blot analysis revealed that ischemia-reperfusion injury significantly upregulates caspase 3 protein expression, while EAcF abolishes this effect. These results provide evidence that the EAcF reestablishes the cardiac contractility and prevents arrhythmias; it is suggested that EAcF could be used to reduce injury caused by cardiac reperfusion. However more clinical studies should be performed, before applying it in the clinic.

https://doi.org/10.1590/0001-3765202320220514

Psychometric properties of the Brazilian Portuguese version of the Copenhagen Burnout Inventory (CBI) in healthcare professionals
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Moser, Carolina M.

; Tietbohl-Santos, Bárbara

; Arenas, Daniel Luccas

; Xavier, Aurora

; Ornell, Felipe

; Borges, Rogerio Boff

; Gabbard, Glen O.

; Laskoski, Pricilla B.

; Hauck, Simone

Trends in Psychiatry and Psychotherapy

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2023, Volume 45 elocation e20210362

Abstract: En | Text: En | PDF: En

Abstract Introduction Burnout syndrome (BS) in healthcare professionals (HCP) has been a major concern, and even more so during the coronavirus disease 2019 (COVID-19) pandemic. The need for adequate tools to assess BS is urgent. The objective of this study was to validate the Brazilian Portuguese version of the Copenhagen Burnout Inventory (CBI) in HCP. Methods The sample comprised 1,054 Brazilian HCP. Data were collected for 1 month (May-2020 to June-2020) using an online self-administered questionnaire. Results All three CBI dimensions demonstrated optimal reliability. All consistency measures attained values > 0.90. Split-half correlation values with Spearman-Brown reliability were higher than 0.8. The parallel analysis suggested two factors: personal burnout (PB) and work-related burnout (WB) items were associated with factor 1, and client-related burnout (CB) items were associated with factor 2. Conclusion Our study corroborates the validity of the Brazilian Portuguese version of the CBI, pointing to a close relation between PB and WB in HCP. A public domain tool with evidence quality to ensure sufficient content validity can aid in burnout evaluation and encourage both expansion of the research field and accurate detection and treatment of this syndrome in Brazilian HCP.

https://doi.org/10.47626/2237-6089-2021-0362

Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil)
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Meneghini, Vandrize

; Tebar, William R.

; Santos, Itamar Souza

; Janovsky, Carolina Castro Porto Silva

; Almeida-Pititto, Bianca de

; Lotufo, Paulo A.

; Goulart, Alessandra C.

; Bensenor, Isabela M.

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 6 elocation e000640

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To determine the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions in middle-aged and older adults. Materials and methods: Cross-sectional analyses included a self-reported medical diagnosis of psoriasis and thyroid function from the 3rd visit (2017-2019) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). TSH, FT4, and FT3 levels were analyzed as continuous variables and quintiles, and TPOAb positivity and subclinical hypothyroidism as a yes/no variable. Logistic regression models were built as crude and adjusted by main confounders (age, sex, education level, race/ethnicity, and smoking). Results: From 9,649 participants (52.3% women; 59.2 ± 8.7 years old), the prevalence of psoriasis was 2.8% (n = 270). TSH, FT4, TPOAb positivity, and subclinical hypothyroidism were not associated with psoriasis in the main analyses. In the stratified analysis, our findings showed positive associations of the lowest (OR = 2.01; 95% CI 1.05-3.84; p = 0.036) and the highest (OR = 2.13; 95% CI 1.12-4.05; p = 0.022) quintiles of FT4 and a protective association of TPOAb positivity (OR = 0.43; 95% CI 0.19-0.98; p = 0.046) with prevalent psoriasis in women. In the logistic regression for FT3, participants in the 1st quintile showed a statistically significant association with psoriasis for the whole sample (OR = 1.66; 95% CI 1.11-2.46; p = 0.013) and for men (OR = 2.25; 95% CI 1.25-4.04; p = 0.007) in the sex-stratified analysis. Conclusions: The present study showed that the association of FT4 levels with psoriasis are different according to sex, with a possible U-shaped curve in women but not in men. Although there were some associations of FT3 with psoriasis, they may be a consequence of non-thyroidal illness syndrome. Further prospective data may clarify the association of thyroid function and psoriasis.

https://doi.org/10.20945/2359-3997000000640

Soldier flies (Diptera: Stratiomyidae) on semideciduous seasonal forest fragments, with a list of species for São Paulo State, Brazil, and two new records of species for the country
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Fachin, Diego Aguilar

; Buzati, Vitória Rubra dos Santos

; Silva, Vera Cristina

; Onody, Helena Carolina

Revista Brasileira de Entomologia

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2023, Volume 67 N. 2 elocation e20230006

Abstract: En | Text: En | PDF: En

ABSTRACT Although the species richness of Stratiomyidae (Diptera) in Brazil (~340 species) is one of the highest for the family worldwide, we still do not know the actual number of species, the extent of their distribution, or the species seasonal dynamics for a single area in the Neotropics. The soldier fly fauna in the semideciduous seasonal forests, which cover a major area of the countryside of the state of São Paulo, is poorly known compared to the best-known areas in the Atlantic Forest for stratiomyids, such as the ombrophilous forests on the southeast coast. With the constant habitat fragmentation of the remnants of the semideciduous forests in the state for crops and pastures for cattle, we are losing valuable data about biodiversity. This study details the stratiomyids for a single area in the Neotropical Region, using a standardized collecting methodology with Malaise traps, from May 2010 to December 2011. Here, we provide a list of 41 stratiomyid species and 25 genera in eight subfamilies from a total of 1,533 specimens collected in the Reserva Biológica e Ecológica Augusto Ruschi, Sertãozinho, Brazil. The current number of species/morphospecies reported for the state of São Paulo is raised to 113, with Merosargus golbachi James, 1971 in James and McFadden, 1971 and M. tripartitus James, 1971 in James and McFadden, 1971 reported for the first time to Brazil. Our analyses estimate even higher richness in the studied area, probably between 48 to 114 species, indicating that further collection efforts are needed.

https://doi.org/10.1590/1806-9665-rbent-2023-0006

Safety of genetically modified glyphosate-tolerant eucalyptus designed for integrated weed management
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Avisar, Dror

; Dias, Tatiane B.

; Santos, Anselmo A. dos

; Galan, Maria P.

; Gonsalves, José M. W

; Graça, Rodrigo N.

; Livne, Sivan

; Manoeli, Alexandre

; Drezza, Thaís R.

; Porto, Antonio C. M.

; Rocha, Carolina S.

; Pinheiro, Ana Cristina

Advances in Weed Science

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2023, Volume 41 elocation e020230032

Abstract: En | Text: En | PDF: En

Background Eucalyptus is the primary cultivated wood species in Brazil, covering 7.5 million hectares. Weed competition in eucalyptus plantations reduces yield and increases operational costs. FuturaGene/Suzano has developed genetically modified (GM) eucalyptus varieties with glyphosate herbicide tolerance (HT) as a modern tool for improving weed management practices in plantations. The first event received regulatory approval for commercial deployment in 2021. However, the introgression of a new GM trait into eucalyptus, a non-isogenic species, cannot be achieved through selfing or backcrossing. To overcome this limitation and expedite the introgression of HT into the breeding population, multiple GM events were generated, in various genetic backgrounds and genomic locations, enabling simultaneous crossing with numerous elite parents. Objective To characterize the newly developed HT GM eucalyptus events and assess their safety for the environment and wood production. Methods HT GM eucalyptus events were subjected to genome sequencing and glyphosate tolerance testing. Biosafety analyses and environmental impact assessments were conducted through field trials in various eucalyptus cultivation regions, comparing the HT GM eucalyptus with conventional clones. Results The new events proved highly tolerant to glyphosate and displayed different genomic insertion sites. No adverse effects on non-target organisms were observed, and there were no significant differences in the soil microbiota or decomposition profile.Conclusions: The HT GM events have been proven to be safe, posing a low risk to the environment, humans, and animals. Consequently, these HT GM eucalyptus varieties can be confidently utilized for wood production.

https://doi.org/10.51694/advweedsci/2023;41:00019

Production of irrigated cherry tomatoes in economical planting beds with mulching
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Santos, Roberto E. dos

; Ferraz, Edimir X. L.

; Nascimento, Antônio H. C. do

; Lira, Raquele M. de

; Vasconcelos, Isaac L. S. de

; Santana, Irlândio de S.

; Sá, Carlos A. de S.

Revista Caatinga

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2023, Volume 36 N. 4 Pages 907 - 915

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Technologies that improve water use efficiency (WUE) and increase crop yields are essential for the development of a responsible and productive agriculture. Therefore, the objective of this study was to evaluate economical planting beds with the use of mulching and application of different irrigation water depths as a water-saving technology, and determine the irrigation water depth that promote the optimal plant development and fruit yield and quality of two cherry tomato cultivars. The experiment was conducted at the Federal Rural University of Pernambuco, Serra Talhada, PE, Brazil. A randomized block experimental design with split-plots (5×2) was used, with plots consisting of five irrigation water depths (25%, 50%, 75%, 100%, and 125% of the crop evapotranspiration - ETc) and subplots consisting of two cherry tomato cultivars (Carolina and Yubi), with four replications, totaling 40 experimental units. The development of tomato plants was evaluated through biometric measurements of stem diameter, plant height, and canopy area. Additionally, the following variables were evaluated during fruit harvest: number of fruits, mean fruit weight, fruit diameter, fruit yield, WUE, titratable acidity, pH, and soluble solids content. The economical planting beds promoted increases in WUE. Irrigation water depths lower than 100% of ETc resulted in better plant development and higher fruit yield, number of fruits, and WUE for the evaluated cherry tomato plants. The cultivar Carolina exhibited higher production performance compared to Yubi.

RESUMO Tecnologias que promovam o aumento da eficiência do uso da água (EUA) e incremento na produtividade é indispensável para o desenvolvimento de uma agricultura responsável e produtiva. Nesse sentido, objetivou-se avaliar ‘canteiros econômicos’ com a utilização de mulching, aplicando diferentes lâminas de irrigação para consolidar o uso desses canteiros como uma tecnologia que propicia a economia de água, da mesma forma que, encontrar a lâmina de irrigação que promova o melhor desenvolvimento, rendimento produtivo e qualidade de duas cultivares de tomatecereja. A pesquisa foi conduzida na Universidade Federal Rural de Pernambuco em Serra Talhada - PE. Utilizou-se o delineamento experimental em blocos casualizados com parcelas subdivididas (5 x 2), onde foram consideradas parcelas cinco lâminas de irrigação (25, 50, 75, 100, e 125% da Evapotranspiração da cultura - ETc) e subparcelas duas cultivares de tomate-cereja (Carolina e Yubi), com quatro repetições, totalizando 40 unidades experimentais. O desenvolvimento do tomateiro foi avaliado mediante coletas biométricas de diâmetro do caule, altura da planta e área da copa. Ademais, durante a colheita foi avaliado o número de frutos, massa média dos frutos, diâmetro dos frutos, produtividade, EUA, acidez titulável, potencial hidrogeniônico e sólidos solúveis dos frutos. Os canteiros econômicos promoveram aumento da EUA. Lâminas de irrigação inferiores a 100% da ETc possibilitaram maior desenvolvimento, produtividade, número de frutos e EUA do tomatecereja. A cultivar Carolina apresentou melhor desempenho produtivo comparado a Yubi.

https://doi.org/10.1590/1983-21252023v36n418rc

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Publication date: 2022-10-11

Abstract: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

10.

Skin-to-skin contact and deaths in newborns weighing up to 1800 grams: a cohort study
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Goudard, Marivanda J.F.

; Lamy, Zeni C.

; Marba, Sérgio T.M.

; Cavalcante, Milady C.V.

; Santos, Alcione M. dos

; Azevedo, Vivian M.G.de O.

; Costa, Roberta

; Guimarães, Carolina N.M.

; Lamy-Filho, Fernando

Jornal de Pediatria

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jul 2022, Volume 98 N. 4 Pages 376 - 382

Abstract: En | Text: En | PDF: En

Abstract Objective: To evaluate the association between dose of skin-to-skin contact (SSC) per day and initiation time with the occurrence of deaths in newborns with weight up to 1800g. Method: Multicentric cohort in five Brazilian neonatal units, including newborns with a birth weight of ≤1800g. The time of SSC was registered in individual file, by the team or family during the hospitalization. Maternal and newborn data were obtained through questionnaires applied to mothers and in medical records. Classification Tree was used for data analysis. Results: The performance of the first SSC after 206h was significantly associated with death (p = 0.02). Although there was no association between SSC/day and death (p = 0.09), the number of deaths among those who performed more than 146.9 minutes/day was lower (3;1.5%) than among those who performed this practice for a shorter time (13;6.4%), a fact considered of great clinical importance. Early and late infections present statistically significant associations with the outcome. The chance of death was equal to zero when there was no early infection in the group with the longest duration of SSC. This probability was also equal to zero in the absence of late sepsis for the group with less than 146.9 minutes/day of SSC. Conclusions: The first SSC before 206 hours of life is recommended in order to observe a reduction in the risk of neonatal death. Staying in SSC for more than 146.9 min/day seems to be clinically beneficial for these neonates mostly when it was associated with the absence of infection.

https://doi.org/10.1016/j.jped.2021.09.001

11.

Molecular characterization of nontuberculous Mycobacteria in a tuberculosis and HIV reference unit in the State of Amazonas, Brazil
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Lima, Ana Carolina de Oliveira de

; Schmid, Karen Barros

; Melo, Hilda Ferreira de

; Athayde, Rafaella Christine

; Monte, Rossiclea Lins

; Almeida, Isabela Neves de

; Miranda, Silvana Spíndola de

; Kritski, Afrânio

; Rossetti, Maria Lucia

; Cordeiros-Santos, Marcelo

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0613-2021

Abstract: En | Text: En | PDF: En

ABSTRACT Background: In recent years, the prevalence of nontuberculous mycobacterial (NTM) infections has increased in different regions of the world. The American Thoracic Society (ATS) recommends standardized identification criteria, reinforcing the need for faster and less complicated clinical and laboratory techniques. Methods: In this retrospective study, NTM species isolated from pulmonary, extrapulmonary, and disseminated samples from patients treated at a TB/HIV reference unit in the State of Amazonas from 2011 to 2014 were identified through a combination of molecular techniques. Results: To identify the molecular technique, 50 cryopreserved NTM cultures were recovered and subcultivated in culture medium. The potentially pathogenic NTM species identified were M. avium, M. intracellulare, M. kansasii, M. chelonae, M. abscessus, M. fortuitum, and M. peregrinum. Results of GenoType® showed moderate agreement with those of genomic sequencing (kappa = 0.60), whereas the results obtained by the PRA-hsp65 technique disagreed with the results obtained by sequencing (kappa = 0.49). Conclusions: Our findings highlight that GenoType CM is a good method for the identification of NTM, as well as the need for the application of standardized criteria, such as those set forth by the ATS.

https://doi.org/10.1590/0037-8682-0613-2021

12.

Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
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Bensenor, Isabela M.

; Goulart, Alessandra C.

; Pereira, Alexandre C.

; Brunoni, André R.

; Alencar, Airlane

; Santos, Raul D.

; Bittencourt, Márcio S.

; Telles, Rosa W.

; Machado, Luciana Andrade Carneiro

; Barreto, Sandhi Maria

; de Almeida-Pititto, Bianca

; Janovsky, Carolina Porto Silva

; Sgarbi, José Augusto

; Tebar, William R.

; Meneghini, Vandrize

; Barbosa Junior, Fernando

; Ribeiro, Ana Cristina de Medeiros

; Pasoto, Sandra Gofinet

; Pereira, Rosa Maria R.

; Bonfá, Eloísa

; Sipahi, Aytan M.

; Santos, Itamar de S.

; Lotufo, Paulo A.

Clinics

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2022, Volume 77 elocation 100013

Abstract: En | Text: En | PDF: En

Abstract Objectives This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.

https://doi.org/10.1016/j.clinsp.2022.100013

13.

Guía de práctica clínica de la Sociedad Interamericana de Cardiología sobre prevención primaria de enfermedad cardiovascular en la mujer
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Sueldo, Mildren A. del

; Rivera, María A. Mendonça

; Sánchez-Zambrano, Martha B.

; Zilberman, Judith

; Múnera-Echeverri, Ana G.

; Paniagua, María

; Campos-Alcántara, Lourdes

; Almonte, Claudia

; Paix-Gonzales, Amalia

; Anchique-Santos, Claudia V.

; Coronel, Claudine J.

; Castillo, Gabriela

; Parra-Machuca, María G.

; Duro, Ivanna

; Varletta, Paola

; Delgado, Patricia

; Volberg, Verónica I.

; Puente-Barragán, Adriana C.

; Rodríguez, Adriana

; Rotta-Rotta, Aida

; Fernández, Anabela

; Izeta-Gutiérrez, Ana C.

; Ancona-Vadillo, Ana E.

; Aquieri, Analía

; Corrales, Andrea

; Simeone, Andrea

; Rubilar, Bibiana

; Artucio, Carolina

; Pimentel-Fernández, Carolina

; Marques-Santos, Celi

; Saldarriaga, Clara

; Chávez, Christian

; Cáceres, Cristina

; Ibarrola, Dahiana

; Barranco, Daniela

; Muñoz-Ortiz, Edison

; Ruiz-Gastelum, Edith D.

; Bianco, Eduardo

; Murguía, Elena

; Soto, Enrique

; Rodríguez-Caballero, Fabiola

; Otiniano-Costa, Fanny

; Valentino, Giovanna

; Rodríguez-Cermeño, Iris B.

; Rivera, Ivan R.

; Gándara-Ricardo, Jairo A.

; Velásquez-Penagos, Jesús A.

; Torales, Judith

; Scavenius, Karina

; Dueñas-Criado, Karen

; García, Laura

; Roballo, Laura

; Kazelian, Lucía R.

; Coussirat-Liendo, Macarena

; Costa-Almeida, María C.

; Drever, Mariana

; Lujambio, Mariela

; Castro, Marildes L.

; Rodríguez-Sifuentes, Maritza

; Acevedo, Mónica

; Giambruno, Mónica

; Ramírez, Mónica

; Gómez, Nancy

; Gutiérrez-Castillo, Narcisa

; Greatty, Onelia

; Harwicz, Paola

; Notaro, Patricia

; Falcón, Rocío

; López, Rosario

; Montefilpo, Sady

; Ramírez-Flores, Sara

; Verdugo, Silvina

; Murguía, Soledad

; Constantini, Sonia

; Vieira, Thais C.

; Michelis, Virginia

; Serra, César M.

Archivos de cardiología de México

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2022, Volume 92 Suppl. 2 Pages 1 - 68

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.24875/acm.22000071 450 downloads

14.

Recovery of bioactive compounds from an agro-industrial waste: extraction, microencapsulation, and characterization of jaboticaba(Myrciaria cauliflora Berg) pomace as a source of antioxidant
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SANTOS, SUELEN S. DOS

; PARAÍSO, CAROLINA M.

; COSTA, SILVIO CLÁUDIO DA

; OGAWA, CAMILLA YARA L.

; SATO, FRANCIELLE

; MADRONA, GRASIELE S.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 N. 4 elocation e20191372

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the extraction of bioactive compounds from jaboticaba pomace, produce microcapsules by spray dryer technique, and characterize antioxidant compounds. A factorial experimental design was used in the extraction step. Maltodextrin (DE 10) was used as an encapsulating agent, in a ratio of 1: 1 (w/w), in the microencapsulation process. It was observed the increase of all bioactive compounds analyses comparing jaboticaba pomace with the extract. ATR-FTIR spectroscopy showed a vibrational stretching aromatic ring (1718 – 1731 cm-1) typical for anthocyanins. The Gaussian deconvolution presented extract peak area 7.56% higher than pomace. The encapsulating agent protected anthocyanins during the drying process. Microencapsulation of bioactive compounds from jaboticaba pomace can be useful for food applications whereas they are a rich source of antioxidant compounds. Moreover, the use of agro-industrial waste is promising linked to the use of clean technology as water as an antioxidant extractor.

https://doi.org/10.1590/0001-3765202220191372

15.

A Rare Case of Drug Induced Liver Injury Secondary to Empagliflozin
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Nunes, Ana Luísa

; Santos, Daniela

; Figueiredo, Carolina

; Ferreira, Diana M.

; Lima, Jandira

; Santos, Arsénio

Medicina Interna

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dec 2021, Volume 28 N. 4 Pages 30 - 34

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A hepatotoxicidade apresenta um amplo espetro de manifestações clínicas. O diagnóstico constitui um desafio, não só devido ao vasto número de hepatotóxicos, mas particularmente se a capacidade de induzir toxicidade por determinada substância é desconhecida. A empagliflozina associa-se a múltiplos efeitos adversos, mas não de forma convincente à hepatotoxicidade. Apresentamos o caso de uma doente do sexo feminino, de 70 anos, diabética, que desenvolveu sintomas gastrointestinais 1 mês após introdução da em-pagliflozina. Verificou-se elevação das enzimas hepáticas. Ecograficamente visualizou-se microlitíase vesicular, mas sem obstrução confirmada das vias biliares. Excluídas outras causas de doença hepática. Após biópsia hepática foi diagnosticada hepatotoxicidade secundária à empagliflozina. Objetivou-se resolução completa clínica e analítica após sus-pensão do antidiabético oral. Foram reportados apenas dois casos de hepatotoxicidade desde o licenciamento da empagliflozina, tornando este caso mais interessante e permitindo sensibilizar os médicos para um diagnóstico precoce e trata-mento adequado.

Abstract Drug induced liver injury (DILI) is a condition with a wide clinical spectrum. The diagnosis represents a challenge not only due to the large number of known hepatotoxic products but especially when the substance involved is not known to induce liver damage. Empagliflozin is linked to several adverse effects but has not been convincingly associated to DILI. We report a case of a 70-year-old type 2 diabetic woman that presented with gastrointestinal symptoms 1 month after empagliflozin introduction. Elevated hepatic enzymes were found and despite ultrasound evidence of vesicular microlithiasis, no biliary obstruction was confirmed. Other causes of liver injury were excluded and the diagnosis of DILI secondary to empagliflozin was made after liver biopsy. Complete clinical and laboratorial resolution was verified after empagliflozin withdrawal. Only two cases of DILI were reported since empagliflozin licensure which makes this case more interesting, alerting clinicians to an early diagnosis and appropriate treatment.

https://doi.org/10.24950/rspmi.cc.131.4.2021 16 downloads

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