Abstract We describe the toxicity of multiwalled carbon nanotubes (MWCNTs) in two aquatic species: Danio rerio and Artemia salina. Fish were exposed to 25 mg L-1, 50 mg L-1, and 100 mg L-1 MWCNTs for 7 days. After exposure, the gills from D. rerio showed lamellar fusion and epithelial lifting in the secondary lamellae, and vasodilation in the primary lamellae. In the gills, heat shock protein 70 and Bax (pro apoptotic member) were stained more intensely in the treated groups than in the control group. The nauplii of A. salina were exposed to 25 µg L-1, 50 µg L-1, and 100 µg L-1 MWCNTs for 96 h. After exposure, the nauplii from the control group presented 20 % mortality, whereas the 25 µg mL-1, 50 µg mL-1, and 100 µg L-1 groups had 46.7 %, 70 %, and 100 % mortality, respectively. The nauplii exposed to 25 µg mL1 and 50 µg mL1 MWCNTs had black aggregates in the intestine because of the uptake of nanomaterials. In addition, the 25 µg mL-1 and 50 µg mL-1 MWCNT groups had black aggregates attached onto the body surface, appendages of the second pair, and mandibles.The results revealed the toxic effects of MWCNTs on the two aquatic organisms, and both species showed great potential for toxicological evaluation of MWCNTs in aquatic environments.

ABSTRACT BACKGROUND AND OBJECTIVES: Recent research has shown that undergraduate students are more susceptible to stressful situations due to the need to exercise various skills, and that this factor is a potential trigger for temporomandibular joint dysfunction (TMD) syndrome. In view of this, there is a need to highlight, through scientific studies, the fact that young students may be more vulnerable to the development of anxiety and stress, which is also associated with the incidence and/or development of bruxism and TMD. The present study’s objective was to describe the intensity of symptoms of anxiety, depression and stress and to characterize the presence and severity of TMD symptoms in dentistry students. METHODS: The sample consisted of 118 students. All of them completed the Índice Anamnésico de Fonseca (Fonseca Anamnesis Index - IAF) questionnaire and the shortened version of the Depression, Anxiety and Stress Scale (DASS-21), which provide relevant information about the sample under investigation and allowed us to acquire epidemiological data about TMD symptoms, associated risk sources and repercussions on quality of life. The data was tabulated and categorized. Descriptive statistical analysis and linear association between the scales are presented. RESULTS: In response to the DASS-21, the three subscales showed that 51% of the individuals had some level of depression, 54% some degree of stress and 61% some level of anxiety. The presence of TMD symptoms was present in 67% of the sample. There was a linear association between the intensity of symptoms of the three subscales of the DASS-21 and the severity of symptoms according to the IAF. CONCLUSION: The information and results obtained in this study revealed a prevalence of signs of anxiety and TMD symptoms in dentistry students.

RESUMO JUSTIFICATIVA E OBJETIVOS: Pesquisas recentes alertam que acadêmicos do curso de graduação estão mais suscetíveis a situações de estresse devido à necessidade de exercer diversas habilidades, esse fator é um potencial desencadeador da síndrome da disfunção da articulação temporomandibular (DTM). Diante disso, surge a necessidade de evidenciar, mediante estudos científicos, o fato de que os estudantes jovens podem mostrar-se mais vulneráveis para o desenvolvimento de ansiedade e estresse, estando também associada a incidência e/ou desenvolvimento do bruxismo e da DTM. O objetivo deste estudo foi descrever a intensidade dos sintomas de ansiedade, depressão, estresse e caracterizar a presença e gravidade dos sintomas de DTM em acadêmicos de odontologia. MÉTODOS: A amostra foi de 118 acadêmicos. Todos preencheram o questionário e Índice Anamnésico de Fonseca (IAF) e a versão reduzida da Escala de Depressão, Ansiedade e Estresse (DASS-21), os quais fornecem informações relevantes sobre a amostra investigada e permitiu adquirir dados epidemiológicos acerca de sintomas de DTM, fontes de risco associadas e repercussão sobre a qualidade de vida. Os dados foram tabulados e categorizados. Apresenta-se a análise estatística descritiva e associação linear entre as escalas. RESULTADOS: Em resposta ao DASS-21, as três subescalas demonstraram que 51% dos indivíduos apresentam algum nível de depressão; 54% algum grau de estresse e 61% algum nível de ansiedade. A presença de sintomas de DTM está presente em 67% da amostra. Houve uma associação linear entre a intensidade dos sintomas das três subescalas da DASS-21 com a gravidade dos sintomas pelo IAF. CONCLUSÃO: As informações e resultados obtidos no presente estudo revelaram prevalência de sinais de ansiedade e sintomas de DTM em acadêmicos do curso de Odontologia.

Resumo Neste estudo, nosso objetivo foi mapear as evidências disponíveis sobre os fatores de risco à saúde mental dos profissionais de saúde trabalhadores da linha de frente durante a pandemia de COVID-19. Trata-se de uma revisão sistemática que seguiu os critérios dos Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A busca foi realizada independentemente, por quatro pesquisadores, seguindo os critérios de seleção nas bases de dados eletrônicas PubMed Central, Ovid Technologies, GALE Academic Onefile, Science Citation Index Expanded. No processamento de dados foi utilizado o software Zotero, responsável por criar e importar itens de acordo com os critérios estabelecidos pela pesquisa. Foram encontrados 18.733 artigos, dos quais 2.722 foram excluídos, a partir do programa Zotero, por estarem duplicados, e outros 366 excluídos manualmente. Após aplicação dos critérios de seleção, 43 artigos entraram na análise final desta revisão. Recomenda-se a elaboração de novas pesquisas científicas, sobretudo colocando como objeto a análise da saúde mental desses trabalhadores, com o objetivo de embasar a elaboração e implementação de programas e políticas públicas de saúde mental para os trabalhadores.

Abstract The aim of the present study was to map the available evidence on the mental health risk factors of frontline health professionals during the COVID-19 pandemic. This is a systematic review that followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The search was independently carried out by four researchers, following the selection criteria in the electronic databases: PubMed Central, Ovid Technologies, GALE Academic Onefile, Science Citation Index Expanded. The data processing used Zotero software, responsible for creating and importing items according to the criteria established by the research. A total of 18,733 articles were found, of which 2,722 were excluded by the Zotero software because they were in duplicate, and another 366 were manually excluded. After applying the selection criteria, 43 articles entered the final analysis of this review. It is recommended that new scientific research be carried out, especially focusing on the analysis of health workers’ mental health, aiming at providing the basis to create and implement public mental health programs and policies for workers.

Abstract The present study aimed to perform the cross-cultural adaptation of the Digital Health Literacy Instrument (DHLI) for native Brazilian Portuguese-speaking adolescents (DHLI-BrA). Cross-cultural adaptation consisted of the following steps: translation, assessment, and adjustments by the expert committee to ensure cultural equivalence; back-translation, and synthesis of back-translations. Cognitive testing was then performed in a pretest with adolescents using cognitive interviews with probing questions on the item's understanding interpretation and response options. Cronbach’s alpha coefficient and McDonald’s omega were used to estimate the instrument’s reliability. Forty-two Brazilian adolescents participated in the study (mean age: 16.0 ± 2.0 years; range: 13 to 19 years). Items that were difficult to understand were adapted to the context of Brazilian adolescents. Cronbach’s alpha coefficient and McDonald’s omega for the 21 items of the DHLI-BrA were, respectively, 0.79 and 0.80. Cronbach’s alpha coefficient for the subscales of the self-report instrument was 0.53-0.79 (range), demonstrating good reliability in the total instrument and moderate reliability in the subscales. This study provides the cross-cultural adapted version of the Digital Health Literacy Instrument (DHLI), which is an instrument for measuring digital Health literacy, for use in Brazilian adolescents (DHLI-BrA).

Resumo O estudo teve o objetivo de adaptar transculturalmente o Digital Health Literacy Instrument (DHLI) para adolescentes nativos do idioma português do Brasil (DHLI-BrA). O estudo de adaptação transcultural consistiu nas seguintes etapas: tradução, avaliação e adequação de equivalência cultural da tradução por comitê de especialistas; retrotradução e síntese das retrotraduções. Foi realizada a testagem cognitiva em pré-teste com adolescentes, utilizando-se entrevistas cognitivas com perguntas de sondagem sobre a compreensão e interpretação dos itens e opções de resposta. O alfa de Cronbach e ômega de McDonald’s foram utilizados para estimar a confiabilidade do instrumento. Participaram do pré-teste 42 adolescentes brasileiros com média de idade de 16,0 ± 2,0 (variação de 13-19) anos. Os itens com dificuldade de compreensão foram adaptados ao contexto dos adolescentes brasileiros. O coeficiente alfa de Cronbach e o ômega de McDonald’s, para os 21 itens do DHLI-BrA foi respectivamente, 0,79 e 0,80. O coeficiente alfa de Cronbach para as subescalas do instrumento de autorrelato foi de 0,53-0,79 (variação), demonstrando boa confiabilidade no instrumento total e confiabilidade moderada nas subescalas. Este estudo fornece a versão adaptada transculturalmente do Digital Health Literacy Instrument (DHLI), um instrumento de mensuração do letramento digital em saúde, para utilização em adolescentes brasileiros (DHLI-BrA).

Abstract The aim of the present study was to map the available evidence on the mental health risk factors of frontline health professionals during the COVID-19 pandemic. This is a systematic review that followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The search was independently carried out by four researchers, following the selection criteria in the electronic databases: PubMed Central, Ovid Technologies, GALE Academic Onefile, Science Citation Index Expanded. The data processing used Zotero software, responsible for creating and importing items according to the criteria established by the research. A total of 18,733 articles were found, of which 2,722 were excluded by the Zotero software because they were in duplicate, and another 366 were manually excluded. After applying the selection criteria, 43 articles entered the final analysis of this review. It is recommended that new scientific research be carried out, especially focusing on the analysis of health workers’ mental health, aiming at providing the basis to create and implement public mental health programs and policies for workers.

Resumo Neste estudo, nosso objetivo foi mapear as evidências disponíveis sobre os fatores de risco à saúde mental dos profissionais de saúde trabalhadores da linha de frente durante a pandemia de COVID-19. Trata-se de uma revisão sistemática que seguiu os critérios dos Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A busca foi realizada independentemente, por quatro pesquisadores, seguindo os critérios de seleção nas bases de dados eletrônicas PubMed Central, Ovid Technologies, GALE Academic Onefile, Science Citation Index Expanded. No processamento de dados foi utilizado o software Zotero, responsável por criar e importar itens de acordo com os critérios estabelecidos pela pesquisa. Foram encontrados 18.733 artigos, dos quais 2.722 foram excluídos, a partir do programa Zotero, por estarem duplicados, e outros 366 excluídos manualmente. Após aplicação dos critérios de seleção, 43 artigos entraram na análise final desta revisão. Recomenda-se a elaboração de novas pesquisas científicas, sobretudo colocando como objeto a análise da saúde mental desses trabalhadores, com o objetivo de embasar a elaboração e implementação de programas e políticas públicas de saúde mental para os trabalhadores.

Abstract The objective of the present study was to answer the question, “What are the factors associated with the prevalence of depressive symptoms in community health agents”. This cross-sectional, quantitative, and analytical study used a Patient Health Questionnaire - 9 to check the depressive symptoms and a questionnaire on the socio-demographic and occupational conditions. A Poisson multiple regression with robust variance was performed, considering a significance level of 5% (p < .05). Six hundred seventy-three community health agents participated in the study. The depressive symptoms prevalence was 19.0% (N = 128). There was an association with females (RP:1.09; IC:1.03-1.05), working time as a community health agent over six years (RP:1.12; IC:1.06-1.17), job dissatisfaction (RP:1.13; IC:1.07-1.19) and the variable being religious (RP:.90; IC:.84-.97) as a protection factor. There was high depressive symptoms prevalence among the community health agents associated with socio-demographic factors.

Resumo O objetivo do presente estudo foi responder à pergunta “Quais são os fatores associados à prevalência de sintomas depressivos em agentes comunitários de saúde”. É um estudo transversal, quantitativo e analítico no qual utilizou instrumento Patient Health Questionnaire - 9 para verificar os sintomas depressivos e um questionário sobre as condições sociodemográficas e ocupacionais. Realizou-se regressão múltipla de Poisson com variância robusta, considerando um nível de significância de 5% (p < .05). Participaram do estudo 673 agentes comunitários de saúde. A prevalência para os sintomas depressivos foi de 19.0% (N = 128). Houve associação com o sexo feminino (RP:1.09; IC:1.03-1.05), tempo de trabalho como agente comunitário de saúde acima de 6 anos (RP:1.12; IC:1.06-1.17), insatisfação no trabalho (RP:1.13; IC:1.07-1.19) e a variável ser religioso (RP:.90; IC:.84-.97) como fator de proteção. Verificou-se alta prevalência de sintomas depressivos entre agentes comunitários de saúde havendo associação com fatores sociodemográficos e ocupacionais.

Abstract This study analyzes the characteristics of the top 100 most-cited papers related to tooth bleaching. A literature search was performed on the Web of Science up to March 2022. The number of citations was cross-matched with the citation count on Scopus and Google Scholar. The following data were collected: number and density of citations; authorship; year and journal of publication; study design and thematic; keywords; institution and country of origin. Spearman’s correlation and Poisson regression were used to determine associations between the number of citations and study characteristics. The VOSviewer software was used to generate collaborative network maps for the authors and keywords. The number of citations ranged from 66 to 450. Papers were published between 1981 and 2020. The most frequent study design and topic were laboratory-based studies and ‘interaction of the bleaching agent with dental tissues’, respectively. Cochran M, Loguercio AD, Matis B, Reis A, and Suliman M were the authors with the highest number of papers. The countries with the most papers were the United States of America (USA) (28%) and Brazil (20%). Indiana University and State University of Ponta Grossa were the institutions with the most papers (6% each). There was a very strong correlation among the number of citations of the three databases. The 100 most-cited papers related to tooth bleaching were mainly published by the USA and Brazil, with laboratory-based studies addressing topics related to the effects of bleaching agents on tooth structure being the most prevalent.

Resumo Este estudo analisa as características dos 100 artigos mais citados relacionados ao clareamento dental. Uma pesquisa bibliográfica foi realizada na Web of Science até março de 2022. O número de citações foi cruzado com a contagem de citações na Scopus e na Google Scholar. Foram coletados os seguintes dados: número e densidade de citações; autoria; ano e periódico de publicação; desenho do estudo e temática; palavras-chave; instituição e país de origem. A correlação de Spearman e a regressão de Poisson foram usadas para determinar associações entre o número de citações e as características do estudo. O software VOSviewer foi utilizado para gerar mapas de rede colaborativa para os autores e palavras-chave. O número de citações variou de 66 a 450. Os artigos foram publicados entre 1981 e 2020. O desenho e o tópico de estudo mais frequentes foram estudos laboratoriais e interação do agente clareador com tecidos dentários, respectivamente. Cochran M, Loguercio AD, Matis B, Reis A e Suliman M foram os autores com maior número de artigos. Os países com mais artigos foram os Estados Unidos da América (EUA) (28%) e o Brasil (20%). A Universidade de Indiana e a Universidade Estadual de Ponta Grossa foram as instituições com mais artigos (6% cada). Houve uma correlação muito forte entre o número de citações das três bases de dados. Os 100 artigos mais citados relacionados ao clareamento dentário foram publicados principalmente pelos EUA e Brasil, sendo os estudos laboratoriais que abordaram tópicos relacionados aos efeitos dos agentes clareadores na estrutura dentária os mais prevalentes.

Abstract The objective of this study was to evaluate the effects of creep feeding during the pre-weaning stage on the performance of piglets at nursery phase, as well as to estimate the economic viability of its application. A total of 125 piglets were exposed to creep feeding and evaluated qualitatively regarding diet intake and quantitatively regarding weight gain. After determining the eaters and non-eaters’ piglets, 48 of these animals were evaluated in the nursery phase. Piglets are blocked (initial weigh and sex) and divided into eaters (E, n=24) and non-eaters (NE, n=24). Time to start feed intake, growth performance data and economic viability were analyzed. At pre-weaning phase no weight difference was observed, and only 24.5% of piglets consumed the creep feed after 12 days of exposure. At nursery phase, the E group presented a 250% faster consumption in the first 24 hours of housing, 18.3% greater daily feed intake and 22.0% greater daily gain for whole experimental length, when compared to NE group. The economic evaluation demonstrated a 269% and 225% greater economic profit and return on investment for E. Therefore, the application of creep feeding in pre-weaning improves the piglets’ performance during nursery phase and is economically viable.

ABSTRACT Objective To characterize the immunophenotypic profile of acute leukemias in the population of the state of Bahia, Brazil. Methods This is a descriptive, retrospective study. From 2014 to 2018, 796 new cases of acute leukemia were evaluated. The data were obtained from analysis of reports and records of tests performed by flow cytometry immunophenotyping. All individuals of all age groups diagnosed as acute lymphoblastic leukemia or acute myeloid leukemia were included in the study. Demographic variables and expression of leukemia antigens were evaluated. Results Most cases were diagnosed as acute myeloid leukemia and 42.7% as acute lymphoblastic leukemia. Significant differences were found in expression of markers in acute leukemias when age groups were compared, as well as in demographic characteristics. B-cell acute lymphoblastic leukemia was more prevalent than cases of T-cell origin. Assessing the aberrant markers in acute myeloid leukemias, the non-acute promyelocytic leukemia group presented expression of CD7 and CD56 as the most frequent ones. In B-cell acute lymphoblastic leukemia, the most frequent aberrant markers were CD66c, CD13 and CD33. Conclusion Significant differences were found as to several antigens when comparing adults and children, and these findings may contribute to future studies correlating the phenotypic profile to genetic characteristics and therapeutic response, including specific antigen therapies, which may be better targeted.

Abstract The aim of the present study was to perform in vitro and in vivo assessments of the antineoplastic action of 4-amino-pyrimidine encapsulated in liposomes. Liposomes were prepared and characterized for particle size and drug encapsulation and submitted to long-term stability tests. Cytotoxicity assays were performed in HeLa cells. Antineoplastic activity was investigated using the experimental sarcoma 180 tumor in Swiss albino mice. Encapsulation efficiency was 82.93 ± 0.04% and no significant changes were found with respect to particle size or pH after centrifugation and mechanical agitation tests. The in vitro results at concentration of 20 μg/mL indicated a considerable reduction in cell viability after treatment with encapsulated pyrimidine (75.91%). The in vivo assays using the compounds in encapsulated and free forms and 5-fluorouracil achieved tumor inhibition rates of 66.47 ± 26.8%, 50.46 ± 16.24% and 14.47 ± 9.22%, respectively. Mitotic counts demonstrated a greater reduction in the number of mitoses in animals treated with liposomal pyrimidine (32.15%) compared to those treated with the pyrimidine free (87.69%) and 5-fluorouracil (71.39%). This study demonstrated that the development of liposome formulations containing 4-amino-pyrimidine is a promising alternative for overcoming limitations related to the toxicity of current cancer treatment, ensuring greater therapeutic efficacy.

Abstract Objective To analyze the scientific evidence regarding the effectiveness of using ozone to disinfect surfaces based on an integrative literature review. Methods A search was carried out in the SciELO, MEDLINE, LILACS, PubMed, Science Direct databases. Eleven articles published January 2010 to August 2021 were analyzed. All employed the experimental laboratory research model and achieved different levels of disinfection by O3, however, with varied surfaces and products tested, in addition to different methodological procedures. Results The majority had an inhibition rate by O3 equal to or greater than 90%, thus proving the effectiveness of this agent as a surface disinfectant, even with variations in parameter values such as concentration and exposure time, in all selected articles, even those that did not prove the effectiveness of O3. Conclusion This review shows the inhibitory power that O3 has on different pathogens, even if there are variables in the factors used for this purpose, highlighting it in front of other disinfectants. Thus, it corroborates the composition of surface disinfection protocols and decision-making among managers and committees about sanitizing technologies.

Resumen Objetivo Analizar las evidencias científicas con respecto a la eficacia del uso del ozono para la desinfección de superficies a partir de una revisión integradora de la literatura. Métodos Se realizó una búsqueda en los bancos de datos electrónicos: SciELO, MEDLINE, LILACS, PubMed, Sciense Direct. Se analizaron 11 artículos, publicados en el período de enero de 2010 a agosto 2021. Todos utilizaron el modelo de investigación experimental laboratorial y obtuvieron distintos niveles de desinfección por O3, pero utilizando distintas superficies y productos, además de distintos procedimientos metodológicos. Resultados La mayoría presentó una tasa de inhibición por O3 igual o superior al 90 %, lo que comprueba la eficacia de ese agente como desinfectante de superficies, aunque existan variaciones en los valores de los parámetros, como concentración y tiempo de exposición, en todos los artículos seleccionados, incluso en los que no se comprobó la eficacia del O3. Conclusión Esta revisión evidencia el poder inhibitorio que el O3 presenta ante distintos patógenos, aunque existan variables en los factores utilizados para esa finalidad, por lo que se destaca ante otros desinfectantes. De esta forma, se confirma la composición de protocolos de desinfección de superficies y la toma de decisiones entre gestores y comisiones sobre tecnologías de desinfección.

Resumo Objetivo Analisar as evidências científicas com relação à eficácia do uso do ozônio para desinfecção de superfícies a partir de uma revisão integrativa de literatura. Métodos Realizou-se busca nos bancos de dados eletrônicos: SciELO, MEDLINE, LILACS, PubMed, Sciense Direct. Foram analisados onze artigos, publicados no período de janeiro de 2010 a agosto de 2021. Todos empregaram o modelo de investigação experimental laboratorial e alcançaram diferentes níveis de desinfecção pelo O3, no entanto, com variadas superfícies e produtos testados, além de diferentes procedimentos metodológicos. Resultados A maioria apresentou taxa de inibição pelo O3 igual ou superior a 90%, comprovando assim a eficácia desse agente como desinfetante de superfícies, mesmo havendo variações de valores dos parâmetros como, concentração e tempo de exposição, em todos os artigos selecionados, até mesmo nos que não comprovaram a eficácia do O3. Conclusão Essa revisão evidencia o poder inibitório que o O3 possui sobre diferentes patógenos, mesmo que haja variáveis nos fatores utilizados para esse fim, destacando-o frente a outros desinfetantes. Corrobora, assim, na composição de protocolos de desinfecção de superfícies e na tomada de decisão entre gestores e comissões acerca de tecnologias saneantes.

Abstract Objective To analyze emotional intelligence among nursing students during the COVID-19 pandemic and describe emotional attention, clarity and repair scores in managing emotions. Methods This is a quantitative, observational cross-sectional study, comprising 121 nursing students at the Universidade Federal do Vale do São Francisco. Data collection was performed using a self-administered form containing the Informed Consent Form, a sociodemographic questionnaire and the Trait Meta-Mood Scale-24, validated for use in Portuguese. Data were submitted to statistical treatment using the Statistical Package for the Social Sciences, version 20.0. Results There were no significant differences between gender, sociodemographic data, and graduation period with Trait Meta-Mood Scale-24 scores. However, fourth and eighth semester students had significantly lower averages on this scale (p=0.015). Conclusion The need to address emotional intelligence throughout the nursing graduation was evidenced, in addition to reinforcing the psychological support of students, based on services already provided by the university.

Resumen Objetivo Analizar la inteligencia emocional de estudiantes de enfermería durante la pandemia de COVID-19 y describir los puntajes de atención emocional, claridad y reparación en la gestión de las emociones. Métodos Se trata de un estudio cuantitativo, observacional de diseño transversal, compuesto por 121 estudiantes de la carrera de Enfermería de la Universidad Federal do Vale do São Francisco. La recopilación de datos se realizó a través de un formulario autoaplicado que contenía el Consentimiento Informado, un cuestionario sociodemográfico y la escala Trait Meta-Mood Scale-24, validada para uso en idioma portugués. Los datos pasaron por tratamiento estadístico utilizando el programa Statistical Package for the Social Sciences, versión 20.0. Resultados No hubo diferencias significativas entre sexo, datos sociodemográficos y semestre de la carrera con el puntaje de la Trait Meta-Mood Scale-24. Sin embargo, los alumnos del cuarto y del octavo semestre presentaron promedios considerablemente inferiores en esta escala (p=0,015). Conclusión Se evidenció la necesidad de tratar la inteligencia emocional a lo largo de la carrera de enfermería, además de reforzar la contención psicológica de los estudiantes, a partir de servicios que la universidad ya ofrece.

Resumo Objetivo Analisar a inteligência emocional entre estudantes de enfermagem na pandemia de COVID-19 e descrever os escores de atenção emocional, clareza e reparação na gestão das emoções. Métodos Trata-se de um estudo quantitativo, observacional de delineamento transversal, composto por 121 estudantes do Curso de Enfermagem da Universidade Federal do Vale do São Francisco. A coleta de dados foi realizada por meio de um formulário autoaplicável contendo Termo de Consentimento Livre e Esclarecido, questionário sociodemográfico e a escala Trait Meta-Mood Scale-24, validado para o uso em língua portuguesa. Os dados foram submetidos a tratamento estatístico utilizando-se o programa Statistical Package for the Social Sciences, versão 20.0. Resultados Não houve diferenças significativas entre sexo, dados sociodemográficos e período da graduação com a pontuação do Trait Meta-Mood Scale-24. Entretanto, os alunos do quarto e do oitavo semestre apresentaram significativamente menores médias desta escala (p=0,015). Conclusão Evidenciou-se a necessidade de abordar a inteligência emocional ao longo da graduação em enfermagem, além de reforçar o amparo psicológico dos estudantes, a partir de serviços já disponibilizados pela universidade.

Abstract The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, α2 adrenergic receptors, and prostaglandins, but not antisecretory or anti-H. pylori properties.

SUMMARY OBJECTIVE: The aim of this study was to evaluate the correlation between P-wave indexes, echocardiographic parameters, and CHA2DS2-VASc score in patients without atrial fibrillation and valvular disease. METHODS: This retrospective cross-sectional study included patients of a tertiary hospital with no history of atrial fibrillation, atrial flutter, or valve disease and collected data from June 2021 to May 2022. The exclusion criteria were as follows: unavailable medical records, pacemaker carriers, absence of echocardiogram report, or uninterpretable ECG. Clinical, electrocardiographic [i.e., P-wave duration, amplitude, dispersion, variability, maximum, minimum, and P-wave voltage in lead I, Morris index, PR interval, P/PR ratio, and P-wave peak time], and echocardiographic data [i.e., left atrium and left ventricle size, left ventricle ejection fraction, left ventricle mass, and left ventricle indexed mass] from 272 patients were analyzed. RESULTS: PR interval (RHO=0.13, p=0.032), left atrium (RHO=0.301, p<0.001) and left ventricle diameter (RHO=0.197, p=0.001), left ventricle mass (RHO=0.261, p<0.001), and left ventricle indexed mass (RHO=0.340, p<0.001) were positively associated with CHA2DS2-VASc score, whereas P-wave amplitude (RHO=-0.141, p=0.02), P-wave voltage in lead I (RHO=-0.191, p=0.002), and left ventricle ejection fraction (RHO=-0.344, p<0.001) were negatively associated with the same score. The presence of the Morris index was associated with high CHA2DS2-VASc (p=0.022). CONCLUSION: Prolonged PR interval, Morris index, increased left atrium diameter, left ventricle diameter, left ventricle mass, and left ventricle indexed mass values as well as lower P-wave amplitude, P-wave voltage in lead I, and left ventricle ejection fraction values were correlated with higher CHA2DS2-VASc scores.

RESUMO O objetivo do presente ensaio é refletir acerca da ideia de uma condição colonizada das investigações em atividade física e saúde, bem como, sobre a urgência de uma agenda decolonial para o desenvolvimento de pesquisas nesta área. Assumimos que o método epidemiológico hegemônico tem sido reproduzido acriticamente e de forma submissa. Propomos, assim, romper com a colonização deste saber epidemiológico do Norte global para resolvermos nossos próprios problemas de pesquisa. Para tanto, entendemos ser urgente refletirmos sobre uma epistemologia decolonial que não esteja atrelada à perspectiva dos fatores de risco, escute com as demandas das populações, bem como, contribua para superar as iniquidades nas quais as populações estão expostas. saúde como área submissa Propomos assim pesquisa tanto risco expostas

RESUMEN El objetivo de este ensayo es reflexionar sobre la idea de una condición colonizada de las investigaciones en actividad física y salud, así como sobre la urgencia de una agenda decolonial para el desarrollo de investigaciones en esta área. Suponemos que el método epidemiológico hegemónico ha sido reproducido acrítica y sumisamente. Proponemos, por tanto, romper con la colonización de este saber epidemiológico del Norte global para resolver nuestros propios problemas de investigación. Por tanto, entendemos que es urgente reflexionar sobre una epistemología decolonial que no se vincule a la perspectiva de los factores de riesgo, escuche las demandas de las poblaciones, así como contribuya a la superación de las iniquidades a las que están expuestas las poblaciones. salud área sumisamente Proponemos tanto investigación riesgo poblaciones

ABSTRACT The objective of this essay is to reflect on the idea of a colonized condition of investigations in physical activity and health, as well as on the urgency of a decolonial agenda for the development of research in this area. We assume that the hegemonic epidemiological method has been reproduced uncritically and submissively. We propose, therefore, to break with the colonization of this epidemiological knowledge of the global North in order to solve our own research problems. Therefore, we understand that it is urgent to reflect on a decolonial epistemology that is not linked to the perspective of risk factors, listens to the demands of the populations, as well as contributes to overcoming the iniquities to which populations are exposed. health area submissively propose therefore problems Therefore factors exposed