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au:SANTOS, OSMAR SANTOS DOS

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Effectiveness and safety of tocilizumab for COVID-19: a systematic review and meta-analysis of randomized clinical trials
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Almeida, Paula Ribeiro Lopes

; Person, Osmar Clayton

; Puga, Maria Eduarda dos Santos

; Giusti, Maria Fernanda

; Pinto, Ana Carolina Pereira Nunes

; Rocha, Aline Pereira

; Atallah, Álvaro Nagib

Sao Paulo Medical Journal

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apr 2023, Volume 141 N. 2 Pages 168 - 176

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Tocilizumab is an anti-human interleukin 6 receptor monoclonal antibody that has been used to treat coronavirus disease 2019 (COVID-19). However, there is no consensus on its efficacy for the treatment of COVID-19. OBJECTIVE: To evaluate the effectiveness and safety of tocilizumab for treating COVID-19. DESIGN AND SETTING: Systematic Review of randomized controlled trials (RCTs), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil. METHODS: We searched MEDLINE via PubMed, EMBASE, CENTRAL, and IBECS for RCTs published up to March 2021. Two authors selected studies and assessed the risk of bias and the certainty of the evidence following Cochrane Recommendations. RESULTS: Eight RCTs with 6,139 participants were included. We were not able to find differences between using tocilizumab compared to standard care on mortality in hospitalized patients with COVID-19 (risk ratio (RR) 0.97, 95% confidence interval (CI) 0.84 to 1.13; 8 trials; 5,950 participants; low-certainty evidence). However, hospitalized patients under tocilizumab plus standard care treatment seemed to present a significantly lower risk of needing mechanical ventilation (risk ratio = 0.78; 95% CI 0.64−0.94 moderate-certainty of evidence). CONCLUSIONS: To date, the best evidence available shows no difference between using tocilizumab plus standard care compared to standard care alone for reducing mortality in patients with COVID-19. However, as a finding with a practical implication, the use of tocilizumab in association to standard care probably reduces the risk of progressing to mechanical ventilation in those patients. REGISTRATION: osf.io/qe4fs.

https://doi.org/10.1590/1516-3180.2022.0170.r1.01072022

On the Use of Vibration Analysis for Contact Fault Detection in High-Voltage HVCBs
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Reis, Jose Osmar dos

; Silva, Clailton Leopoldo da

; Assunção, Frederico de Oliveira

; Castioni, Julio Cezar Oliveira

; Martins, Rafael

; Xavier, Carlos Eduardo

; Areias, Isac Antonio dos Santos

; Ribeiro Junior, Ronny Francis

; Lambert-Torres, Germano

; Bonaldi, Erik Leandro

; Silva, Luiz Eduardo Borges da

; Oliveira, Levy Ely Lacerda

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e23230286

Abstract: En | Text: En | PDF: En

Abstract As high-voltage circuit breakers (HVCBs) are responsible for switching off the load in the event of anomalies, they suffer various wear and tear, both on their main contacts and on the other actuation mechanisms. Not only load maneuvers but also weather conditions can bring factors that contribute to deterioration and, consequently, contribute to failures of this component that is so important for energy supply. Both failures and maintenance shutdowns generate costs for substations, something that could be minimized if there was monitoring of the condition of the HVCBs. This paper shows a methodology to analyze the vibration signal of HVCB in order to identify and quantify contact failures. The proposed methodology is verified through an experimental setup. The results show that it is possible not only to identify the fault but also to assess its intensity using vibration analysis.

https://doi.org/10.1590/1678-4324-2023230286

Homogeneidade, Eventos Extremos e suas Causas Climáticas: Bacia Hidrográfica do Rio São Francisco
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Rocha, Lucas Henrique dos Santos

; Silva, Djane Fonseca da

; Kayano, Mary Toshie

; Bonfim, Osmar Evandro Toledo

Revista Brasileira de Meteorologia

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jun 2022, Volume 37 N. 2 Pages 199 - 212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetiva-se nessa pesquisa identificar áreas climatologicamente homogêneas, identificar e quantificar os eventos extremos ocorridos nesta Bacia utilizando o índice de Precipitação Normalizado (SPI, sigla em inglês), bem como conhecer suas causas climáticas. Foram utilizados dados de precipitação da ANA com período de 1912 a 2019, e usadas vários métodos estatísticos. áreas pluviometricamente homogêneas identificadas foram o Baixo São Francisco/Submédio São Francisco; Médio São Francisco e Alto São Francisco, com períodos chuvosos e sistemas atuantes distintos. O MSF apresentou os extremos mais intensos e o BSF apresentou os eventos menos intensos da Bacia. Ocorreram mais episódios de chuva moderada, severa ou extrema em toda a região do rio São Francisco do que de secas moderada, severa e extrema, conforme o SPI. Através da Análise de Ondaletas verificou-se que estes índices oscilam em várias escalas temporais: sazonal, semestral, interanual, a do ENOS, ENOS estendido, a do Dipolo do Atlântico, a dos ciclos solares e da Oscilação Interdecadal do Pacífico.

Abstract The objective of this research is to identify climatologically homogeneous areas, to identify and quantify the extreme events that occurred in this Basin using the Standardized Precipitation Index (SPI), as well as to know its climatic causes. ANA precipitation data from 1912 to 2019 was used, and various statistical methods were used. Rainfall homogeneous areas are the Lower São Francisco/Middle São Francisco, Middle São Francisco and Upper São Francisco, with different rainy periods and active systems. MSF presented the most intense extremes and BSF presented the least intense events in the Basin. There were more episodes of moderate, severe or extreme rain in the entire São Francisco River region than of moderate, severe and extreme droughts, according to the SPI. Through Wave Analysis it was found that these indices fluctuate in various time scales: seasonal, half-yearly, inter-annual, that of ENSO, extended ENSO, that of the Atlantic Dipole, that of solar cycles and the Interdecadal Oscillation of the Pacific.

https://doi.org/10.1590/0102-77863710122

Effectiveness and safety of tocilizumab for COVID-19: a systematic review and meta-analysis of randomized clinical trials
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Almeida, Paula Ribeiro Lopes

; Person, Osmar Clayton

; Puga, Maria Eduarda dos Santos

; Giusti, Maria Fernanda

; Pinto, Ana Carolina Pereira Nunes

; Rocha, Aline Pereira

; Atallah, Álvaro Nagib

Sao Paulo Medical Journal

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2022, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1516-3180.2022.0170.r1.01072022

[SciELO Preprints] - Governmental non-drug strategies for COVID-19 - Scoping review
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Clayton Person, Osmar Almeida, Paula Ribeiro Lopes Puga, Maria Eduarda dos Santos Atallah, Álvaro Nagib

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Publication date: 2021-05-25

Abstract: En Pt

Background and objectives: The new coronavirus pandemic has so far caused around 3 million deaths worldwide and significant changes in the population's routine. Social distancing, the use of masks and general restrictions are advocated by governments as mandatory non-drug primary strategies, which must be incorporated into society for a long time. The present study aimed to evaluate the effectiveness of governmental non-drug strategies for COVID-19. Study design: This is a scoping review. Methodology: Search for studies at Medline / PUBMED, at the Cochrane Library and at EMBASE. DECS descriptors were used and there were no geographical and temporal restrictions on publications. The inclusion criteria involved human studies covering exposure to governmental non-drug strategies, with social distance, the use of masks and lockdown being a priority. Results: The search strategy retrieved 365 citations and, of these, 9 studies were included in this review. Discussion: Most studies involve observational studies and suggest that social distance, lockdown and the use of facial masks can reduce the incidence of new cases of COVID-19. Conclusion: The strategies of physical distance, lockdown and the use of facial masks had a beneficial result in most of the studies analyzed, contributing to the reduction of new cases of COVID-19.

Contextualização e objetivos: A pandemia do novo coronavírus causou até o momento cerca de 3 milhões de mortes no mundo e mudanças significativas na rotina da população. O distanciamento social, o uso de máscaras e as restrições gerais são preconizadas pelos governos como estratégias primárias obrigatórias não medicamentosas, que devem ser incorporadas à sociedade por muito tempo. O presente estudo teve como objetivo avaliar a eficácia das estratégias governamentais não medicamentosas para COVID-19. Desenho de estudo: Trata-se de scoping review. Metodologia: Procedeu-se à busca por estudos no Medline/PUBMED, na Cochrane Library e na EMBASE. Foram utilizados descritores do DECS e não houve restrição geográfica e temporal das publicações. Os critérios de inclusão envolveram estudos em humanos abrangendo a exposição às estratégias governamentais não medicamentosas, sendo prioridade o distanciamento social, o uso de máscaras e o lockdown. Resultados: A estratégia de busca recuperou 365 citações e, destas, 9 estudos foram incluídos nessa revisão. Discussão: A maioria dos estudos envolve estudos observacionais e sugerem que o distanciamento social, o lockdown e o uso de máscaras faciais podem reduzir a incidência de novos casos de COVID-19. Conclusão: As estratégias de distanciamento físico, de lockdown e o uso de máscaras faciais apresentaram resultado benéfico na maioria dos estudos analisados, contribuindo para a redução de novos casos de COVID-19.

https://doi.org/10.1590/SciELOPreprints.2355

MACROALGAE Fucus vesiculosus OIL: BIODIESEL PRODUCTION USING ALKALINE TRANSESTERIFICATION
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Petry, Bruno Roberto

; Rial, Rafael Cardoso

; Freitas, Osmar Nunes de

; Barbosa, Joyce Mara dos Santos

; Cavalheiro, Leandro Fontoura

; Nazário, Carlos Eduardo Domingues

; Viana, Luíz Henrique

Química Nova

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apr 2021, Volume 44 N. 4 Pages 410 - 414

Abstract: En | Text: En | PDF: En

This work studied the obtaining of methyl biodiesel and ethyl biodiesel using alkaline transesterification from macroalgae Fucus vesiculosos oil (FVO). FVO has 86.59% of its composition in unsaturated fatty acids, with a greater quantity of linoleic acid and oleic acid, a chemical composition near the soybean oil, the most used raw material for the production of biodiesel. Linoleic acid (47.88%), and oleic acid (34.66%) are the fatty acids present in the greatest amount in FVO, and unsaturated fatty acids correspond to 86.59% the composition of FVO, a composition of fatty acids close to that of soybean oil, which is the oil most produced and used for the production of biodiesel. To obtain methyl biodiesel (MBFVO) and ethyl biodiesel (EBFVO) the molar ratio oil: alcohol 1: 3 and 1% alkaline catalyst, NaOH, was used. The yield of the transesterification reaction was evaluated by varying the reaction time between 30 and 60 minutes and the highest yields were obtained after 60 minutes of reaction. In order to check the quality of the obtained biodiesel, the properties acidity index, iodine value, water content, specific mass at 20 ºC, oxidative stability, cold filter plugging point and kinematic viscosity were evaluated. The oxidative stability had an induction period below the recommended, but it can be corrected with the addition of antioxidants to the biodiesel. All other physical and chemical properties had values within the stipulated by the regulatory agencies, indicating that the macroalgae Fucus vesiculosus can be a raw material in potential for production of biodiesel.

https://doi.org/10.21577/0100-4042.20170704 82 downloads

[SciELO Preprints] - Intervention with ivermectin for of COVID-19: synopsis of evidence
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Person, Osmar Clayton Puga, Maria Eduarda dos Santos Atallah, Alvaro Nagib Amaral, José Luiz Gomes do

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Publication date: 2021-03-01

Abstract: En Pt

Context: COVID-19 is a viral disease that has recently emerged and is associated with severe respiratory distress syndrome (SARS). Its potential for severity and impact on the health of the population and the global economy is a prime object in the search for effective therapy and ivermectin has been recommended for prevention and treatment. Objective: To evaluate the evidence in the literature regarding the use of ivermectin for the prevention and treatment of cases of COVID-19. Study design: This is a synopsis of evidence. Methods: We searched the electronic databases PubMed (1966-2021), EMBASE (1974-2021) and Clinical Trials (2021) and two evidence megabusers: Turning Research Into Practice (TRIP) database (2021) and Epstemonikos (2021). There was no geographic or language restriction, using DeCS descriptors and terms (Health Sciences Descriptors). The synthesis method involved the combination of similar studies in a narrative review. Results: 527 citations were identified and 5 studies were included. There are few completed clinical trials, all of which have a small sample size. Discussion: Most of the studies available in the literature are based on in vitro therapeutic responses and the recommendation for use in humans has been based on the findings of these studies. The question cannot be answered with current studies, and quality clinical trials are recommended. Conclusions: There is currently no support in the literature for the use of ivermectin in the prevention or treatment of COVID-19.

Contexto: A COVID-19 é uma doença viral que surgiu recentemente e associada à síndrome da angústia respiratória severa (SARS). Seu potencial de gravidade e impacto na saúde da população e economia global é objeto primordial na busca por uma terapêutica eficaz ea ivermectina tem sido recomendada para prevenção e tratamento da COVID-19. Objetivo: avaliar como evidências na literatura relativa ao uso de ivermectina para prevenção e tratamento de casos de COVID-19. Desenho de estudo: Trata-se de sinopse de evidências. Métodos:Procedeu-se à busca de bases eletrônicas de dados PubMed (1966-2021), EMBASE (1974-2021) e Clinical Trials (2021) e em dois megabuscadores de evidências: Turning Research Into Practice (TRIP) database (2021) e Epstemonikos ( 2021). Não houve restrição geográfica e de idioma, sendo utilizados descritores e termos do DeCS (Descritores em Ciências da Saúde). O método de síntese envolveu uma combinação de estudos semelhantes em uma revisão narrativa. Resultados: Foram identificados 527 citações e 5 estudos foram incluídos. Há poucos ensaios clínicos concluídos todos apresentam pequena. Discussão: A maioria dos estudos disponíveis na literatura respalda-se em respostas terapêuticas in vitroea recomendação para uso em humanos tem-se baseado nos achados desses estudos. A questão não pode ser respondida com os estudos atuais, sendo recomendada a realização de ensaios de qualidade. Conclusões: Não há suporte atualmente na literatura para uso da ivermectina na prevenção ou tratamento COVID-19.

https://doi.org/10.1590/SciELOPreprints.1871

Development of the “interactivelab” platform for network analysis in soccer
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Menuchi, Marcos Rodrigo Trindade Pinheiro

; Anjos, Matheus Almeida Santos

; Mendes, Claudia Thalita Andrade

; Silva, Matheus Santos Cardoso da

; Nascimento, Osmar Silva

; Honda, Marcelo Ossamu

Motriz: Revista de Educação Física

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2021, Volume 27 elocation e10210015220

Abstract: En | Text: En | PDF: En

Abstract Aims: To introduce a platform called “InteractiveLab” (ILab) for collecting and analyzing ball passing networks during soccer games. Methods: The software was organized to collect data through a mobile interface and touch screen and simultaneously access that data from a remote database, allowing the automated acquisition, storage, and processing of data during games through an application from the web. The analysis is based on the concept of social networks, characterized by the interaction of players through passing exchanges. Results: This descriptive study presents the construction architecture and functioning of the developed software. It also presents the results of intra- and inter-rater reliability and a comparison with the manual collection method. Data were extracted and viewed according to the attacking unit classifications, with the following four outcomes: (a) interception, (b) lost ball, (c) incompletion, and (d) completion. This classification allows for the configuration of the data for a more precise analysis. Some limitations were highlighted, as well as future projections for the improvement of applications and analysis of the interactions network in the context of soccer. Conclusion: It is concluded that the InteractiveLab platform is a viable and beneficial tool that offers new possibilities for analysing performance in soccer. Moreover, given the lack of solutions that work similarly, this product also has market potential.

https://doi.org/10.1590/s1980-657420210015220 436 downloads

Análise dos Eventos Climáticos Extremos e de Suas Causas Climáticas para Redução de Riscos nas Bacias Hidrográficas Aguapeí e Peixe, São Paulo, Brasil
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Bonfim, Osmar Evandro Toledo

; Silva, Djane Fonseca da

; Kayano, Mary Toshie

; Rocha, Lucas Henrique dos Santos

Revista Brasileira de Meteorologia

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dec 2020, Volume 35 N. spe Pages 755 - 768

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Para melhorar nosso entendimento dos eventos extremos nas Bacias hidrográficas do rio Aguapeí e do rio do Peixe, utilizando análises estatísticas variadas, objetivou-se neste trabalho, detectar oscilações, sistemas ou fenômenos dominantes que influenciam na pluviometria e na ocorrência de eventos extremos nestas bacias, identificar tendências climáticas, e ainda detectar grupos que apresentam comportamento pluviométrico semelhante, utilizando o Método de agrupamento. Além disso, utilizou-se o SPI para análise de eventos extremos locais, cujas variações foram associadas ao El Niño-Oscilação Sul (ENOS) Canônico ou Modoki, e submeteu-se o índice de Prp às Análises de Ondaletas para identificar as causas climáticas da variabilidade pluviométrica. As análises das ondaletas identificaram picos significantes em 0,25 a 0,5 anos, embora uma escala de 22 anos predomine em quase todos os anos. Os anos com índices de precipitação elevados são decorrentes da associação de fenômenos de diferentes escalas temporais, como também, a falta destes, ocasionam anos de baixos índices pluviométricos. Foi constatada uma maior frequência de eventos de secas, contudo, a ocorrência de eventos chuvosos se mostrou de forma mais intensa. Os eventos de chuvas extremas ocorrem principalmente em anos de El Niño canônico, e eventos de secas leves em anos de La Niña Canônico.

Abstract In order to improve our understanding on the extreme events of the hydrographic basins of river Aguapeí and river Peixe, using a variety of statistical analyzes, the objective of this work was to detect oscillations, systems or dominant phenomena that influence rainfall and the occurrence of extreme events in these hydrographic basins, to identify climatic trends, and groups with similar rainfall behavior using the Cluster analysis. In addition, SPI was used to analyze local extreme events, the variations of which were associated with the El Niño- South Oscillation (ENSO) Canonico or Modoki, and the Prp index was subjected to Wave Analysis to identify the climatic causes of rainfall variability. The wavelet analyses identified significant peaks at the 0.25 and 0.5 years although a 22-year time scale predominates during almost all years. Years with high rainfall rates are due to the association of different time scale phenomena, whereas their absences cause low rainfall years. A higher frequency of drought events was found, however, the occurrence of rainy events was more intense. Extreme rainy events occur mainly in canonical El Niño years, and light drought events in canonical La Niña years.

https://doi.org/10.1590/0102-7786355000004 462 downloads

10.

Brinquedos Educativos Associados à Contação de Histórias Aplicados a uma Criança com Deficiência Múltipla
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FELÍCIO, Franciele Aparecida dos Santos

; SEABRA JUNIOR, Manoel Osmar

; RODRIGUES, Viviane

Revista Brasileira de Educação Especial

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mar 2019, Volume 25 N. 1 Pages 67 - 84

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este estudo teve por objetivo analisar os efeitos dos brinquedos educativos associados à contação de histórias na interação de uma criança com deficiência múltipla. Participou do estudo uma criança de dez anos com diagnóstico de deficiência múltipla (paralisia cerebral e deficiência visual). Foi empregado o delineamento de sujeito único, no modelo AB, para verificar e avaliar as variáveis do estudo, sendo a variável dependente as habilidades de interação com os brinquedos educativos. A variável independente caracterizou-se pela aplicação de brinquedos educativos associados à contação de histórias e estratégias adicionais. Como materiais, foram selecionados oito brinquedos do kit da Instituição LARAMARA para cegos, que atendiam ao objetivo da pesquisa. O treinamento baseou-se na contação de histórias seguidas pelo uso de estratégias adaptadas em diferentes situações, totalizando seis sessões para cada brinquedo, divididas em duas etapas, linha de base (A) e intervenção (B). Todas as sessões foram filmadas, analisadas e pontuadas de acordo com a folha de registro, para mensurar a interação do participante com os brinquedos. Como resultados, pode-se demonstrar que, nas fases de linha de base, o participante não interagiu com o brinquedo. Entretanto, quando foi introduzida a intervenção, houve aumento no número de interações com os brinquedos educativos, pois o participante conseguiu manipulá-los e dar função a todos os brinquedos. Em síntese, o uso dos brinquedos educativos associados à contação de histórias pode ser uma possibilidade de intervenção para pessoas com deficiências múltiplas de modo a oferecer mais interação com o brinquedo.

ABSTRACT: This study aimed to analyze the effects of educational toys associated with storytelling in the interaction of a child with multiple disabilities. A ten-year-old child diagnosed with multiple disabilities (cerebral palsy and visual impairment) participated in the study. The single subject design in the AB model was employed to verify and evaluate the study variables of the study, the dependent variable being the interaction abilities with the educational toys. The independent variable was characterized by the application of educational toys linked with storytelling and additional strategies. As resources, eight toys were selected and adapted from the kit of the LARAMARA institution for the blind, which met the research objective. The training was based on storytelling followed by the use of adapted strategies in different situations, totaling six sessions for each toy, divided into two stages, baseline (A) and intervention (B). All sessions were filmed, analyzed and scored according to the rubric gauging, to measure the participant’s interaction with the toys. As results, it can be demonstrated that, in the baseline phases, the participant did not interact with the toy. However, when the intervention was introduced, there was a significant increase in the number of interactions with educational toys, as the participant was able to manipulate them and give function to all the toys. In summary, the use of educational toys associated with storytelling may indicate a possible intervention for people with multiple disabilities with the intention of offering more significant interaction with the toy.

https://doi.org/10.1590/s1413-65382519000100005 3905 downloads

11.

Ractopamine supplementation improves leanness and carcass yield, minimally affecting pork quality in immunocastrated pigs
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Costa, Osmar Antonio Dalla

; Feddern, Vivian

; Athayde, Natalia Bortoleto

; Manzke, Naiana Einhardt

; Roça, Roberto de Oliveira

; Lopes, Letícia dos Santos

; Lima, Gustavo Julio Mello Monteiro de

Scientia Agricola

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may 2018, Volume 75 N. 3 Pages 197 - 207

Abstract: En | Text: En | PDF: En

ABSTRACT: This study was carried out to determine the combining effects of feeding up to 15 mg kg−1 ractopamine (RAC) to physically castrated (PC) pigs or those injected with an anti-GnRF vaccine (IC), on growth performance during suckling, weaning, growing and finishing phases. Out of a total of 1,160 male piglets, 50 % were surgically castrated at age 7, while 50 % underwent immunization against GnRF on the 103rd and 136th day of life. A completely randomized design, with two treatments (PC and IC), was used from the 1st until the 60th day of life. Afterwards, 792 animals, PC and IC, selected according to overall average weight (23.3 ± 0.69 kg) were allotted based on a completely randomized block design with a 2 × 4 factorial arrangement of treatments (castration categories × RAC levels) with 9 replications (11 animals) per main combination effect. IC growing pigs improved feed conversion due to lower average daily feed intake and higher average daily gain (ADG). During the finishing phase, both RAC and immunocastration increased body weight, but the effects were independent. RAC, on its own improved ADG and feed conversion. However, pigs fed 10 mg kg−1 RAC had higher blood lactate compared to those fed lower levels, suggesting that these animals were more susceptible to stress. Muscle depth was influenced only by RAC, whereas fat thickness was lower for IC. Lean meat increased and fat decreased in the shoulder and belly of IC; RAC had a positive effect on belly lean meat only. Either immunocastration or RAC inclusion (at least 5 mg kg−1) promoted muscle gain and fat reduction in pig carcass, adding value to pork.

https://doi.org/10.1590/1678-992x-2016-0321 1330 downloads

12.

Tinnitus and sound intolerance: evidence and experience of a Brazilian group
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Onishi, Ektor Tsuneo

; Coelho, Cláudia Couto de Barros

; Oiticica, Jeanne

; Figueiredo, Ricardo Rodrigues

; Guimarães, Rita de Cassia Cassou

; Sanchez, Tanit Ganz

; Gürtler, Adriana Lima

; Venosa, Alessandra Ramos

; Sampaio, André Luiz Lopes

; Azevedo, Andreia Aparecida

; Pires, Anna Paula Batista de Ávila

; Barros, Bruno Borges de Carvalho

; Oliveira, Carlos Augusto Costa Pires de

; Saba, Clarice

; Yonamine, Fernando Kaoru

; Medeiros, Ítalo Roberto Torres de

; Rosito, Letícia Petersen Schmidt

; Rates, Marcelo José Abras

; Kii, Márcia Akemi

; Fávero, Mariana Lopes

; Santos, Mônica Alcantara de Oliveira

; Person, Osmar Clayton

; Ciminelli, Patrícia

; Marcondes, Renata de Almeida

; Moreira, Ronaldo Kennedy de Paula

; Torres, Sandro de Menezes Santos

Brazilian Journal of Otorhinolaryngology

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mar 2018, Volume 84 N. 2 Pages 135 - 149

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução Zumbido e intolerância a sons são queixas frequentes e subjetivas que podem ter impacto na qualidade de vida do paciente. Objetivo Apresentar uma revisão dos principais pontos, inclusive conceitos, fisiopatologia, diagnóstico e abordagem do paciente com zumbido e sensibilidade a sons. Método Revisão da literatura com levantamento bibliográfico na base de dados da LILACS, SciELO, Pubmed e MEDLINE. Foram selecionados artigos e capítulos de livros sobre zumbido e sensibilidade a sons. Os diversos tópicos foram discutidos por um grupo de profissionais brasileiros e as conclusões, descritas. Resultado A prevalência de zumbido tem aumentado ao longo dos anos, muitas vezes associado a perda auditiva, fatores metabólicos e erros alimentares. A avaliação médica deve ser feita minuciosamente no sentido de orientar a solicitação de exames subsidiários. Os tratamentos disponíveis atualmente variam de medicamentos ao uso de sons com características específicas e técnicas de meditação, com resultados variáveis. Conclusão Foi apresentada uma revisão sobre os temas que permitindo ao leitor uma visão ampla da abordagem dos pacientes com zumbido e sensibilidade auditiva baseada em evidências científicas e experiência nacional.

Abstract Introduction Tinnitus and sound intolerance are frequent and subjective complaints that may have an impact on a patient's quality of life. Objective To present a review of the salient points including concepts, pathophysiology, diagnosis and approach of the patient with tinnitus and sensitivity to sounds. Methods Literature review with bibliographic survey in LILACS, SciELO, Pubmed and MEDLINE database. Articles and book chapters on tinnitus and sound sensitivity were selected. The several topics were discussed by a group of Brazilian professionals and the conclusions were described. Results The prevalence of tinnitus has increased over the years, often associated with hearing loss, metabolic factors and inadequate diet. Medical evaluation should be performed carefully to guide the request of subsidiary exams. Currently available treatments range from medications to the use of sounds with specific characteristics and meditation techniques, with variable results. Conclusion A review on tinnitus and auditory sensitivity was presented, allowing the reader a broad view of the approach to these patients, based on scientific evidence and national experience.

https://doi.org/10.1016/j.bjorl.2017.12.002 28893 downloads

13.

Microbiota indigenous milk, mesophilic lipolytic and proteolytic colonial cheese matured, produced at different times of the year
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Pereira, Elisângela Borsoi

; Pozza, Magali Soares dos Santos

; Olivo, Paula Martins

; Santa, Osmar Dalla

; Pires, Suzana da Cruz

; Borsoi, Joelmir André

; Costa, Patrícia Barcellos

; Pozza, Paulo Cesar

Revista Brasileira de Saúde e Produção Animal

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dec 2017, Volume 18 N. 4 Pages 549 - 559

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O queijo é a forma mais antiga de se conservar os nutrientes do leite possuindo importância nutricional, económica e cultural. Objetivou-se neste estudo identificar qual a melhor época do ano para produção, e período, em meses, para maturação de queijo colonial tradicional, por meio de análise da atividade da água (AW), perda de peso e contagens de micro-organismos ácido láticos, mesófilos proteolíticos e lipolíticos. Foram mantidos os registros de temperatura e umidade relativa do ar. Foi usado delineamento experimental inteiramente casualizado em esquema fatorial duplo, considerando períodos de produção e tempos de maturação. Para todos os períodos de produção avaliados, houve uma redução significativa nos períodos para os valores de AW. As contagens de bactérias ácido-láticas oscilaram entre 104 a 109UFC/g. Houve estabilidade também no número de colónias para micro-organismos mesófilos lipolíticos, até terceiro mês de maturação. Foram constatadas baixas contagens de mesófilos proteolíticos para as amostras produzidas em maio e junho (5,70 e 5,53log), respectivamente. O período de produção referente ao mês de maio e junho correspondentes a UR de 80% e temperaturas médias de 15°C foram os mais efetivos para produção. Em função da presença de Listeria recomenda-se respeitar o tempo mínimo de 60 dias de maturação para a comercialização.

SUMMARY Cheese is the oldest form of preserving milk nutrients having nutritional, economic and cultural importance. The objective of this study was to identify the best time of the year for production, and period, in months, for maturation of traditional colonial cheese, through analysis of water activity, weight loss and counts of lactic acid, mesophilic microorganisms—proteolytic and lipolytic. Records of temperature and relative humidity (RH) were maintained. A completely randomized experimental design was used in a double factorial scheme, considering production periods and maturation times. For all production periods evaluated, there was a significant reduction in the periods for water activity values. The counts of lactic acid bacteria ranged from 104 to 109 CFU/g. There was also stability in the number of colonies for lipolytic mesophilic microorganisms, until the third month of maturation. Low counts of proteolytic mesophiles were observed for the samples produced in May and June (5.70 and 5.53 log), respectively. The production period for the months of May and June corresponding to RH of 80% and average temperatures of 15°C were the most effective for production. Due to the presence of Listeria, it is recommended to respect the minimum time of 60 days of maturation for commercialization.

https://doi.org/10.1590/s1519-99402017000400006 888 downloads

14.

RESPIRATORY MUSCLE STRENGTH IN IDIOPATHIC SCOLIOSIS AFTER TRAINING PROGRAM
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Alves, Vera Lúcia dos Santos

; Avanzi, Osmar

Acta Ortopédica Brasileira

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dec 2016, Volume 24 N. 6 Pages 296 - 299

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To analyze the impact of a physiotherapy protocol in maximum inspiratory and expiratory pressure in patients with adolescent idiopathic scoliosis (AIS) by manovacuometry. AIS may change the respiratory dynamics and the performance of inspiratory and expiratory muscles, affecting ventilatory capacity. Methods: Patients with AIS aged 10 to 20 years old were randomly assigned to receive an aerobic exercise-training program or no treatment. They were evaluated for respiratory muscle strength before and after the treatment period by means of manovacuometry, thorax and spine radiographs. Physical therapy exercising protocol comprised three weekly sessions including stretching and aerobic exercises during four months. Results: Forty five patients received physical therapy and 45 patients received no treatment (control group). The mean maximum inspiratory pressure (Pimax) was -52.13 cm H20 and the maximum expiratory pressure (Pemax) was 62.38 cm H20. There was a significant increase of Pimax and Pemax (p=0,000) in the group receiving physical therapy. There were no drop-outs and no adverse events in this study. Respiratory muscle strength, scoliosis and kyphosis degrees were not statistically correlated. Conclusion: Exercising is beneficial to patients with AIS, who have shown significant increases in respiratory muscle strength after physical therapy. There was no correlation between respiratory pressure and spine deformity. Level of Evidence I, High quality randomized trial.

https://doi.org/10.1590/1413-785220162406120752 2389 downloads

15.

Analysis of musculoskeletal changes in patients with postural roundback
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Alves, Débora Pinheiro Lédio

; Alves, Vera Lúcia dos Santos

; Avanzi, Osmar

Coluna/Columna

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sep 2014, Volume 13 N. 3 Pages 188 - 192

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

OBJETIVO: Analisar as alterações clínicas e radiográficas do paciente com dorso curvo postural. MÉTODOS: Foram estudados 30 pacientes com diagnóstico de dorso curvo postural, sendo 22 do sexo masculino e oito do feminino, com idades entre 10 e 20 anos, encaminhados pelo ambulatório do Grupo de Cirurgia da Coluna da Irmandade da Santa Casa de Misericórdia de São Paulo, SP, Brasil. Os pacientes foram submetidos à avaliação da postura, a testes especiais para verificar as retrações musculares e a exame radiográfico para mensurar as curvaturas da coluna vertebral pelo método de Cobb. RESULTADOS/CONCLUSÃO: Concluímos que no dorso curvo postural existe um aumento moderado da cifose torácica; as curvaturas lombar e cervical não aumentam como mecanismo compensatório; a cabeça apresenta-se anteriorizada e os ombros anteriorizados e rodados medialmente; as retrações musculares estão presentes nos músculos isquiotibiais, flexores do quadril, peitoral menor e adutores do ombro; a mobilidade da coluna lombar está preservada e não existe relação entre a magnitude da curvatura torácica e a retração dos músculos isquiotibiais.

OBJECTIVE: To analyze the clinical and radiographic changes in patients with postural rounded upper back. METHODS: 30 patients diagnosed with postural rounded upper back were studied, being 22 male and eight female, aged between 10 and 20 years, referred by the outpatient clinic of the Grupo de Cirurgia da Coluna of the Irmandade da Santa Casa de Misericórdia de São Paulo, SP, Brazil. Patients underwent assessment of posture, special tests to check for muscle retractions and radiographic examination to measure the curvatures of spine using the Cobb method. RESULTS/CONCLUSION: It is concluded that in the postural roundback there is a moderate increase of the thoracic kyphosis; the lumbar and cervical curvatures do not increase as a compensatory mechanism; the head appears anteriorized and the shoulder is also anteriorized and medially rotated; muscle retractions are present in the hamstrings, hip flexors, pectoralis minor and adductors of the shoulder muscles; the mobility of the lumbar spine is preserved and there is no relationship between the magnitude of thoracic curvature and the retraction of the hamstring muscles.

OBJETIVO: Analizar las características clínicas y radiológicas del paciente con dorso curvo postural. MÉTODOS: Se estudiaron 30 pacientes con diagnóstico de dorso curvado postural, siendo 22 hombres y ocho mujeres, con edades entre 10 y 20 años, encaminados por el ambulatorio del Grupo de Cirurgia da Coluna da Irmandade da Santa Casa de Misericórdia de São Paulo, SP, Brasil. Los pacientes se sometieron a la evaluación de la postura, pruebas especiales para detectar las retracciones musculares y examen radiográfico para medir las curvaturas de la columna vertebral por el método de Cobb. RESULTADOS/CONCLUSIONES: Se concluye que en el dorso curvado postural hay un aumento moderado de la cifosis torácica; las curvaturas lumbar y cervical no aumentan como mecanismo compensatorio; la cabeza se presenta anteriorizada y el hombro también es anteriorizado y con rotación medial; las retracciones musculares están presentes en los músculos isquiotibiales, flexores de la cadera, pectoral menor y aductores del hombro; la movilidad de la columna lumbar se conserva preservada y no hay relación entre la magnitud de la curvatura torácica y la retracción de los músculos isquiotibiales.

https://doi.org/10.1590/S1808-18512014130300389 2430 downloads

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