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1.
Psychometric analysis of the teacher support scale with higher education students
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Abstract The Teacher Support Scale has been used to assess students’ perceived teacher support in compulsory school years. However, the literature requires attention to perceived teacher support in higher education and to the referred measure’s psychometric properties. This study examines the factorial structure, invariance for sex, relations to other variables, and reliability of the Teacher Support Scale with a sample of 262 Portuguese higher education students (M age = 24.36, SD = 7.46), 133 (50.8%) women and 129 (49.2%) men. Results from confirmatory factor analyses suggested that a two-factor measurement model yielded a good fit to the data. Multi-group analyses indicated configural and metric invariance for women and men. Positive correlations among perceived teacher support and students’ academic experiences were found. The Teacher Support Scale might be useful to assess students’ perceived academic and social teacher support, as well as to sustain psychological practices in higher education.
2.
Validation of the Compassion Fatigue Short Scale among Portuguese firefighters
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Rodrigues, Fabiana
; Bártolo, Ana
; Sabino, Daniela
; Santos, Isabel M.
; Pereira, Anabela
; Silva, Carlos F.
; Boscarino, Joseph A.
; Adams, Richard E.
.
Abstract This study aimed to adapt the Compassion Fatigue-Short Scale to Portugal and examine the reliability and validity of the Portuguese version of the scale (Pt-CF-Short Scale) among Portuguese firefighters. The factor structure of the Pt-CF-Short Scale was compared to the one-factor model fit and a two-factor model and second-order factor model in a sample of 512 firefighters. Confirmatory factor analysis procedures confirmed the good fit of a second-order factor model with two first-order factors (secondary trauma and job burnout). The Pt-CF-Short Scale showed good internal consistency evidence. The Kessler Psychological Distress Scale (K-10), the Brief Symptom Inventory (BSI) and WHOQOOL-Bref were used as convergent measures to assess psychological distress, anxiety, depression, and interpersonal sensitivity and quality of life, respectively. The measure presented a strong correlation with psychological distress and weak and negative association with quality of life. The Pt-CF-Short Scale contributes to understanding compassion fatigue and its correlates within the context of emergency workers. Results indicate that this scale is a valid and reliable assessment tool in evaluating compassion fatigue.
Resumo Este estudo teve como objetivo adaptar a Compassion Fatigue-Short Scale para Portugal e examinar a fiabilidade e validade da versão portuguesa da escala (Pt-CFShort Scale) entre bombeiros portugueses. A estrutura fatorial da CF-Short Scale foi comparada com o ajuste do modelo de um fator e um modelo de dois fatores e um modelo de fator de segunda ordem em uma amostra de 512 bombeiros. Os procedimentos de análise fatorial confirmatória confirmaram o bom ajuste de um modelo fatorial de segunda ordem com dois fatores de primeira ordem (trauma secundário e esgotamento profissional). As evidências de consistência interna mostraram bons coeficientes e boa validade convergente foi encontrada ao correlacionar essa escala com sofrimento psíquico, ansiedade, depressão e sensibilidade interpessoal. No entanto, essa medida apresentou associação fraca e negativa com as dimensões do WHOQOL-Bref. A validade discriminante foi confirmada. A escala Pt-CF-short contribui para a compreensão da trajetória da fadiga por compaixão e seus correlatos no contexto dos socorristas. Os resultados indicam que esta escala é uma ferramenta de avaliação válida e confiável na avaliação da fadiga por compaixão.
3.
Enhanced Larvicidal Activity of New 1,2,4-Oxadiazoles against Aedes aegypti Mosquitos: QSAR and Docking Studies
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Silva, Aluízio G. da
; Navarro, Daniela Maria A. F.
; Santos, Geanne K. N.
; Aguiar, Júlio César R. O. F. de
; França, Karla A. de
; Tébéka, Iris Raquel M.
; Anjos, Janaína V. dos
; Silva, João Bosco P. da
; Kanis, Luiz A.
; Srivastava, Rajendra M.
; Neves Filho, Ricardo Antônio W.
; Ramos, Mozart N.
.
The worldwide emergence of viral diseases such as Zika, Dengue, Chikungunya, West Nile and Yellow Fever urge the search for solutions to eliminate their common vector, the Aedes aegypti mosquito. This paper describes the quantitative structure-activity relationship (QSAR) and docking studies of a series of nine 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids (AOPA), 1-9, previously published by our group. Additionally, three new 1,2,4-oxadiazoles, 10-12, have also been synthesized, characterized and studied. The QSAR and docking studies of all compounds, 1-12, clearly indicate that larger hydrophobic substituents such as biphenyl groups attached on position 3 in 1,2,4-oxadiazoles improve the larvicidal activity. It is worthwhile to mention that nanocapsulation of compounds 10-12 were necessary to help their dissolution in water and these three new 1,2,4-oxadiazoles also exhibited approximately equal or higher larvicidal activities compared to the former prototypes at stage L4.
4.
Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023
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Oliveira, Gláucia Maria Moraes de
; Almeida, Maria Cristina Costa de
; Rassi, Daniela do Carmo
; Bragança, Érika Olivier Vilela
; Moura, Lidia Zytynski
; Arrais, Magaly
; Campos, Milena dos Santos Barros
; Lemke, Viviana Guzzo
; Avila, Walkiria Samuel
; Lucena, Alexandre Jorge Gomes de
; Almeida, André Luiz Cerqueira de
; Brandão, Andréa Araujo
; Ferreira, Andrea Dumsch de Aragon
; Biolo, Andreia
; Macedo, Ariane Vieira Scarlatelli
; Falcão, Breno de Alencar Araripe
; Polanczyk, Carisi Anne
; Lantieri, Carla Janice Baister
; Marques-Santos, Celi
; Freire, Claudia Maria Vilas
; Pellegrini, Denise
; Alexandre, Elizabeth Regina Giunco
; Braga, Fabiana Goulart Marcondes
; Oliveira, Fabiana Michelle Feitosa de
; Cintra, Fatima Dumas
; Costa, Isabela Bispo Santos da Silva
; Silva, José Sérgio Nascimento
; Carreira, Lara Terra F.
; Magalhães, Lucelia Batista Neves Cunha
; Matos, Luciana Diniz Nagem Janot de
; Assad, Marcelo Heitor Vieira
; Barbosa, Marcia M.
; Silva, Marconi Gomes da
; Rivera, Maria Alayde Mendonça
; Izar, Maria Cristina de Oliveira
; Costa, Maria Elizabeth Navegantes Caetano
; Paiva, Maria Sanali Moura de Oliveira
; Castro, Marildes Luiza de
; Uellendahl, Marly
; Oliveira Junior, Mucio Tavares de
; Souza, Olga Ferreira de
; Costa, Ricardo Alves da
; Coutinho, Ricardo Quental
; Silva, Sheyla Cristina Tonheiro Ferro da
; Martins, Sílvia Marinho
; Brandão, Simone Cristina Soares
; Buglia, Susimeire
; Barbosa, Tatiana Maia Jorge de Ulhôa
; Nascimento, Thais Aguiar do
; Vieira, Thais
; Campagnucci, Valquíria Pelisser
; Chagas, Antonio Carlos Palandri
.
5.
Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic
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Perez, Jose Angel A.
; Barros Neto, Halésio M.C. de
; Arantes, Renata C.M.
; Gaurisas, Daniela Y.
; Silva, Camila F.
; Alves, Fernanda Maria M.
; Costa, Júlia A.
; Eloi, Paula D.C.
; Fonseca, Thayse S.
; Gavazzoni, Lucas
; Lonskis, Isabella da S.
; Nardi, Ricardo U.
; Nascimento, Pedro O.
; Rodrigues, João Vitor M.
; Santos, Ana Lara F. dos
; Santos, Edson C. dos
; Schroeder, Rafael
; Silva, Luis Carlos da
; Souza, Fernanda dos S.S. de
; Bernardino, Ângelo F.
; Cavalcanti, Guarani H.
; Lindner, Alberto
; Mahiques, Michel M. de
; Millo, Christian
; Reis, Priscila
; Sweetman, Andrew K.
; Roberts, J. Murray
.
Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.
6.
β-Cyclodextrins alter the energy metabolism-related enzyme activities in rats
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IANISKI, FRANCINE R.
; OLIVEIRA, AMANDA L. DE
; MEZZOMO, NATHANA JAMILLE
; FRANCESCHI, ITIANE D. DE
; CARMO, GUILHERME M. DO
; CREMONESE, CAMILA R.
; BALDISSERA, MATHEUS D.
; ZANON, JENIFER P.
; KOLLING, JENIFER
; FRIEDERICH, JORDANA DANIELA
; SILVA, IVANA Z.
; GIONGO, JANICE L.
; FEKSA, LUCIANE R.
; VAUCHER, RODRIGO A.
; WANNMACHER, CLOVIS MILTON D.
; RECH, VIRGINIA C.
.
Abstract Although widely used in medicine, separation technology, and other fields, the effects of cyclodextrins on the activities of phosphoryl transfer enzymes have not been previously evaluated. In vivo studies evaluated the function of cyclodextrins as active compounds. Despite the use of cyclodextrins as active compounds, the effects of cyclodextrins on hepatic and renal tissues remain to be fully elucidated. The primary objective of this study was to evaluate the effects of β- cyclodextrins, methyl-β-cyclodextrin (M-β- cyclodextrins), and (2-hydroxypropyl)-β-cyclodextrin (HP-β-cyclodextrins) on enzyme activities regulating the maintenance of energy homeostasis in the kidney and liver tissues in relation to toxicity. Serum levels of liver and kidney markers were measured, and oxidative stress parameters were assessed. After 60-day treatments, we observed that the administration of β-cyclodextrins and M-β-cyclodextrins inhibited the hepatic activity of pyruvate kinase, an irreversible enzyme within the glycolytic pathway. Additionally, administration of HP-β-cyclodextrins inhibited creatine kinase activity and increased the total sulfhydryl content in kidneys. Here, we demonstrated for the first time that β-cyclodextrins, M-β-cyclodextrins, and HP-β-cyclodextrins cause bioenergetic dysfunction in renal and hepatic tissues. These findings suggest that understanding the balance between cyclodextrins’ efficacy and adverse effects is essential for better accepting their use in medicine.
7.
Control of hairy fleabane in sequential and pre-emergence applications in soybean crops
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Silva, Paulo V. da
; Barros, Daniela M. de
; Domingos, Edson R.
; Monquero, Patrícia A.
; Dias, Roque de C.
; Vendruscolo, Marlon A.
.
ABSTRACT The control of Conyza spp. can be conducted at different times in the soybean crop. This study aimed to evaluate the efficiency of controlling Conyza spp. by positioning herbicides at different times and their selectivity in the soybean crop. The experiment was conducted under field conditions in a randomized block design with four replications. A first application of 2.4-D + glyphosate (975 + 1500 g of active ingredient [a.i.] ha-1) was conducted, followed by the following treatments: glufosinate (500 g i.a. ha-1), diquat (400 g a.i. ha-1), and saflufenacil + glyphosate (50 + 1500 g a.i. ha-1 ) and a third application of the pre-emergents flumioxazin + imazethapyr (60 + 127 g i. a. ha-1), sulfentrazone + diuron (210 + 420 g a.i. ha-1), diclosulam (35 g a.i. ha-1), and s-metolaclhor (1440 g a.i. ha-1), in addition to the control treatment. High percentages of control were obtained with saflufenacil + glyphosate and diquat. Glufosinate provided satisfactory control seven days after the treatment (DAT) application, with regrowth throughout the evaluations, except when diclosulam was applied. The pre-emergent herbicides reduced the emergence of Conyza spp. resulting in 0.25 plants m-2 when flumioxazin + imazethapyr was applied at 28 DAT. Regardless of the treatment, the soybean crop had no significant phytotoxicity. The management of Conyza spp. with the positioning of herbicides at different times proved to be more efficient when the sequential use of diquat and/or saflufenacil + glyphosate and flumioxazin + imazethapyr in pre-emergence was carried out.
RESUMO O controle de espécies de Conyza spp., pode ser efetuado em diferentes períodos na cultura da soja. O objetivo desse trabalho foi avaliar a eficiência no controle de Conyza spp. através do posicionamento de herbicidas em diferentes momentos, e sua seletividade na cultura da soja. O experimento foi realizado em campo no delineamento de blocos ao acaso, com quatro repetições. Foi realizada uma primeira aplicação de 2,4-D + glyphosate (975 + 1500 g de ingrediente ativo [i.a.] ha-1) e na sequencial os tratamentos: glufosinate (500 g i.a. ha-1), diquat (400 g i.a. ha-1) e saflufenacil + glyphosate (50 + 1500 g i.a. ha-1 ) e uma terceira aplicação dos préemergentes flumioxazin + imazethapyr (60 + 127 g i.a. ha-1), sulfentrazone + diuron (210 + 420 g i.a. ha-1), diclosulam (35 g i.a. ha-1) e s-metolaclhor (1440 g i.a. ha-1), além das testemunhas. Altas porcentagens de controle foram obtidas com saflufenacil + glyphosate ou diquat. O glufosinate, proporcionou controle satisfatório 7 dias após a aplicação dos tratamentos (DAT), com rebrotas ao longo das avaliações, exceto quando ocorreu aplicação do diclosulam. Os herbicidas pré-emergentes diminuíram a emergência de Conyza spp. resultando em 0,25 plantas m-2, na aplicação de flumioxazin + imazethapyr aos 28 DAT. Não houve fitotoxicidade significativa na cultura da soja independente do tratamento. O manejo de Conyza spp. através do posicionamento de herbicidas em diferentes momentos, mostrou-se mais eficiente quando realizado a sequencial de diquat e/ou saflufenacil + glyphosate e flumioxazin + imazethapyr em pré-emergência.
8.
Calcium pyruvate as a salt stress mitigator in yellow passion fruit seedlings
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Silva, Francisco de A. da
; Dias, Mirandy dos S.
; Fernandes, Pedro D.
; Lacerda, Cassiano N. de
; Silva, André A. R. da
; Marcelino, Aline D. A. de L.
; Lima, Andrezza M. de
; Barbosa, Daniela D.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
- Journal Metrics
RESUMO Embora a região semiárida do Nordeste brasileiro seja uma grande produtora de maracujá amarelo, os problemas de sais no solo e nas fontes hídricas, em muitas áreas, têm limitado o crescimento e a produção dessa cultura, o que realça a importância de estudos visando a reduzir tais efeitos. Nesse contexto, objetivou-se com este estudo, avaliar o efeito da aplicação foliar de piruvato, como mitigador do estresse salino, sobre a morfofisiologia do maracujazeiro cv. Redondo Amarelo, em fase de mudas. Os tratamentos constaram de três condutividades elétricas da água de irrigação (CEa: 0,8, 2,4 e 4,0 dS m-1) e três concentrações de piruvato (0, 25 e 50 mM), distribuídos em delineamento experimental de blocos casualizados, em esquema fatorial 3 × 3, com quatro repetições e duas plantas por parcela. A irrigação com águas de CEa de 4,0 dS m-1 reduz as variáveis de crescimento, fitomassa, indice de qualidade de Dickson e aumenta o extravasamento de eletrólitos em mudas de maracujazeiro cv. Redondo Amarelo. A aplicação exógena de piruvato de cálcio (25 e 50 mM) favorece as variáveis de crescimento, fitomassa, indice de qualidade de Dickson, teor relativo de água, suculência foliar e reduz o extravasamento de eletrólitos no limbo foliar do maracujá. A aplicação exógena de piruvato atenua o estresse salino, com efeitos benéficos na taxa de assimilação de CO2, transpiração, eficiência da carboxilação instantânea, eficiência intrínseca do uso da água e massa seca das raízes.
ABSTRACT Although the semi-arid region of Northeast Brazil is a major producer of yellow passion fruit, the problems of salts in the soil and water sources, in many areas have limited the growth and production of this crop, which highlights the importance of studies aimed at reducing such effects. In this context, the objective of this study was to evaluate the effect of foliar application of pyruvate, as a mitigator of salt stress, on the morphophysiology of yellow passion fruit, in seedling phase. The treatments consisted of three electrical conductivities of irrigation water (ECw: 0.8, 2.4, and 4.0 dS m-1) and three concentrations of pyruvate (0, 25, and 50 mM), distributed in a randomized block experimental design in a 3 × 3 factorial scheme, with four replications and two plants per plot. Irrigation with ECw of 4.0 dS m-1 reduces growth variables, phytomass, Dickson quality index, and increases electrolyte leakage in passion fruit seedlings cv. Redondo Amarelo. Exogenous application of calcium pyruvate (25 and 50 mM) increased growth, phytomass, Dickson quality index, relative water content and leaf succulence and reduced electrolyte leakage in the leaf blade in passion fruit. Exogenous application of pyruvate attenuates salt stress, with beneficial effects on CO2 assimilation rate, transpiration, instantaneous carboxylation efficiency, intrinsic water use efficiency, and root dry mass.
9.
[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio
Rassi Jr., Anis
Moraes Oliveira, Gláucia M.
Lemos Correia, Luís Claudio
Novaes Ramos Jr., Alberto
Hasslocher-Moreno, Alejandro Marcel
Luquetti Ostermayer, Alejandro
Sousa, Andréa Silvestre de
Amato Vincenzo de Paola, Angelo
Sobral de Sousa, Antonio Carlos
Pinho Ribeiro, Antonio Luiz
Correia Filho, Dalmo
Moraes de Souza, Dilma do Socorro
Cunha-Neto, Edecio
J. A. Ramires, Felix
Bacal, Fernando
Pereira Nunes, Maria do Carmo
Martinelli Filho, Martino
Ibrahim Scanavacca, Maurício
Magalhães Saraiva, Roberto
Alves de Oliveira Júnior, Wilson
M. Lorga-Filho, Adalberto
de Jesus Benevides de Almeida Guimarães, Adriana
Lopes Latado Braga, Adriana
Sarmento de Oliveira, Adriana
V. L. Sarabanda, Alvaro
Yecê das Neves Pinto, Ana
Assis Lopes do Carmo, André
Schmidt, André
Costa, Andréa Rodrigues da
Ianni, Barbara Maria
Markman Filho, Brivaldo
Eduardo Rochitte, Carlos
Thé Macedo, Carolina
Mady, Charles
Chevillard, Christophe
Bittencourt das Virgens, Cláudio Marcelo
Nery de Castro, Cleudson
De Paoli de Carvalho Britto, Constança Felícia
Pisani, Cristiano
do Carmo Rassi, Daniela
C. Sobral Filho, Dario
Rodrigues Almeida, Dirceu
A. Bocchi, Edimar
T. Mesquita, Evandro
de Souza Nogueira Sardinha Mendes, Fernanda
Pereira, Francisca Tatiana
Sperandio da Silva, Gilberto Marcelo
de Lima Peixoto, Giselle
Glotz de Lima, Gustavo
H. Veloso, Henrique
Turin Moreira, Henrique
Bellotti Lopes, Hugo
Masciarelli Francisco Pinto, Ibraim
Pinto Dias, João Carlos
Bemfica, João Marcos
Silva-Nunes, João Paulo
Soares Barreto-Filho, José Augusto
Kerr Saraiva, José Francisco
Lannes-Vieira, Joseli
Menezes Oliveira, Joselina Luzia
V. Armaganijan, Luciana
Martins, Luiz Cláudio
C. Sangenis, Luiz Henrique
Barbosa, Marco Paulo
Almeida-Santos, Marcos Antônio
Simões, Marcos Vinicius
Shikanai-Yasuda, Maria Aparecida
Vieira Moreira, Maria da Consolação
Higuchi, Maria de Lourdes
Costa Monteiro, Maria Rita de Cássia
Felix Mediano, Mauro Felippe
Maia Lima, Mayara
T. Oliveira, Maykon
Moreira Dias Romano , Minna
Nitz, Nadjar
de Tarso Jorge Medeiros, Paulo
Vieira Alves, Renato
Alkmim Teixeira, Ricardo
Coury Pedrosa, Roberto
Aras, Roque
Morais Torres, Rosália
dos Santos Povoa, Rui Manoel
Rassi, Sérgio Gabriel
Salles Xavier, Sérgio
Marinho Martins Alves , Silvia
B. N. Tavares, Suelene
Lima Palmeira, Swamy
da Silva Junior, Telêmaco Luiz
da Rocha Rodrigues, Thiago
Madrini Junior, Vagner
Maia da Costa , Veruska
Dutra, Walderez
This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp;
Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities.
nbsp;
Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp;
The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp;
The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp;
Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.
Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou.
A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica.
Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas.
A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica.
A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp;
Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;
10.
Mathematical modeling and thermodynamic properties in the drying of citron watermelon seeds
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Leite, Daniela D. de F.
; Queiroz, Alexandre J. de M.
; Figueirêdo, Rossana M. F. de
; Santos, Francislaine S. dos
; Silva, Semirames do N.
; Santos, Dyego da C.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
- Journal Metrics
RESUMO A melancia africana é um produto agrícola de excelente potencial econômico. Suas sementes são muito utilizadas para extração de óleo, servindo como fonte energética, demonstrando características nutricionais que a habilitam como produto a ser estudado. Assim, objetivou-se caracterizar quanto à composição físico-química, as sementes de melancia africana, além de determinar a cinética de secagem, ajustar modelos matemáticos aos dados, determinar os coeficientes de difusividade efetiva e propriedades termodinâmicas. As sementes foram submetidas à secagem em secador convectivo, variando-se a temperatura de secagem, com velocidade do ar de 1,0 m s-1. Com o aumento da temperatura de secagem diminuiu o teor de água, atividade de água, teor de cinzas, acidez total titulável, lipídios e açúcar redutor. As sementes de melancia africana são ricas em lipídios e cinzas, tem baixos teores de açúcares e baixa acidez; as cinéticas de secagem foram muito bem descritas pelos modelos Dois Termos e Aproximação da Difusão, seguidos pelos modelos de Midilli e Page, que resultaram em ajustes aceitáveis. A difusividade efetiva acompanhou o aumento da temperatura de secagem, e este comportamento foi satisfatoriamente ajustado por equação do tipo Arrhenius. As variações de entalpia e entropia foram reduzidas com a temperatura de secagem, com aumentos da energia livre de Gibbs.
ABSTRACT Citron watermelon is an agricultural product of excellent economic potential. Its seeds are widely used for oil extraction, serving as an energy source, showing nutritional characteristics that make them a suitable product to be studied. Thus, the objective was to characterize citron watermelon seeds regarding their physicochemical composition, in addition to determining drying kinetics, fitting mathematical models to the data, and determining the effective diffusivity coefficients and thermodynamic properties. The seeds were dried in a convective dryer, varying the drying temperature, with air velocity of 1.0 m s-1. With the increase in drying temperature, there were reductions in moisture content, water activity (aw), ash concentration, total titratable acidity, lipids and reducing sugar. Citron watermelon seeds are rich in lipids and ash, have low sugar concentration and low acidity; their drying kinetics was very well described by the Two Terms and Approximation of Diffusion models, followed by the models of Midilli and Page, which resulted in acceptable fits. Effective diffusivity accompanied the increase in drying temperature, and this behavior was well fitted by an Arrhenius-type equation. Enthalpy and entropy variations were reduced with drying temperature, with increments in Gibbs free energy.
11.
Práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras: uma análise secundária do estudo Fluid-TRIPS
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Freitas, Flavio Geraldo Rezende de
; Hammond, Naomi
; Li, Yang
; Azevedo, Luciano Cesar Pontes de
; Cavalcanti, Alexandre Biasi
; Taniguchi, Leandro
; Gobatto, André
; Japiassú, André Miguel
; Bafi, Antonio Tonete
; Mazza, Bruno Franco
; Noritomi, Danilo Teixeira
; Dal-Pizzol, Felipe
; Bozza, Fernando
; Salluh, Jorge Ibrahin Figueira
; Westphal, Glauco Adrieno
; Soares, Márcio
; Assunção, Murillo Santucci César de
; Lisboa, Thiago
; Lobo, Suzana Margarete Ajeje
; Barbosa, Achilles Rohlfs
; Ventura, Adriana Fonseca
; Souza, Ailson Faria de
; Silva, Alexandre Francisco
; Toledo, Alexandre
; Reis, Aline
; Cembranel, Allan
; Rea Neto, Alvaro
; Gut, Ana Lúcia
; Justo, Ana Patricia Pierre
; Santos, Ana Paula
; Albuquerque, André Campos D. de
; Scazufka, André
; Rodrigues, Antonio Babo
; Fernandino, Bruno Bonaccorsi
; Silva, Bruno Goncalves
; Vidal, Bruno Sarno
; Pinheiro, Bruno Valle
; Pinto, Bruno Vilela Costa
; Feijo, Carlos Augusto Ramos
; Abreu Filho, Carlos de
; Bosso, Carlos Eduardo da Costa Nunes
; Moreira, Carlos Eduardo Nassif
; Ramos, Carlos Henrique Ferreira
; Tavares, Carmen
; Arantes, Cidamaiá
; Grion, Cintia
; Mendes, Ciro Leite
; Kmohan, Claudio
; Piras, Claudio
; Castro, Cristine Pilati Pileggi
; Lins, Cyntia
; Beraldo, Daniel
; Fontes, Daniel
; Boni, Daniela
; Castiglioni, Débora
; Paisani, Denise de Moraes
; Pedroso, Durval Ferreira Fonseca
; Mattos, Ederson Roberto
; Brito Sobrinho, Edgar de
; Troncoso, Edgar M. V.
; Rodrigues Filho, Edison Moraes
; Nogueira, Eduardo Enrico Ferrari
; Ferreira, Eduardo Leme
; Pacheco, Eduardo Souza
; Jodar, Euzebio
; Ferreira, Evandro L. A.
; Araujo, Fabiana Fernandes de
; Trevisol, Fabiana Schuelter
; Amorim, Fábio Ferreira
; Giannini, Fabio Poianas
; Santos, Fabrício Primitivo Matos
; Buarque, Fátima
; Lima, Felipe Gallego
; Costa, Fernando Antonio Alvares da
; Sad, Fernando Cesar dos Anjos
; Aranha, Fernando G.
; Ganem, Fernando
; Callil, Flavio
; Costa Filho, Francisco Flávio
; Dall´Arto, Frederico Toledo Campo
; Moreno, Geovani
; Friedman, Gilberto
; Moralez, Giulliana Martines
; Silva, Guilherme Abdalla da
; Costa, Guilherme
; Cavalcanti, Guilherme Silva
; Cavalcanti, Guilherme Silva
; Betônico, Gustavo Navarro
; Betônico, Gustavo Navarro
; Reis, Hélder
; Araujo, Helia Beatriz N.
; Hortiz Júnior, Helio Anjos
; Guimaraes, Helio Penna
; Urbano, Hugo
; Maia, Israel
; Santiago Filho, Ivan Lopes
; Farhat Júnior, Jamil
; Alvarez, Janu Rangel
; Passos, Joel Tavares
; Paranhos, Jorge Eduardo da Rocha
; Marques, José Aurelio
; Moreira Filho, José Gonçalves
; Andrade, Jose Neto
; Sobrinho, José Onofre de C
; Bezerra, Jose Terceiro de Paiva
; Alves, Juliana Apolônio
; Ferreira, Juliana
; Gomes, Jussara
; Sato, Karina Midori
; Gerent, Karine
; Teixeira, Kathia Margarida Costa
; Conde, Katia Aparecida Pessoa
; Martins, Laércia Ferreira
; Figueirêdo, Lanese
; Rezegue, Leila
; Tcherniacovsk, Leonardo
; Ferraz, Leone Oliveira
; Cavalcante, Liane
; Rabelo, Ligia
; Miilher, Lilian
; Garcia, Lisiane
; Tannous, Luana
; Hajjar, Ludhmila Abrahão
; Paciência, Luís Eduardo Miranda
; Cruz Neto, Luiz Monteiro da
; Bley, Macia Valeria
; Sousa, Marcelo Ferreira
; Puga, Marcelo Lourencini
; Romano, Marcelo Luz Pereira
; Nobrega, Marciano
; Arbex, Marcio
; Rodrigues, Márcio Leite
; Guerreiro, Márcio Osório
; Rocha, Marcone
; Alves, Maria Angela Pangoni
; Alves, Maria Angela Pangoni
; Rosa, Maria Doroti
; Dias, Mariza D’Agostino
; Martins, Miquéias
; Oliveira, Mirella de
; Moretti, Miriane Melo Silveira
; Matsui, Mirna
; Messender, Octavio
; Santarém, Orlando Luís de Andrade
; Silveira, Patricio Júnior Henrique da
; Vassallo, Paula Frizera
; Antoniazzi, Paulo
; Gottardo, Paulo César
; Correia, Paulo
; Ferreira, Paulo
; Torres, Paulo
; Silva, Pedro Gabrile M. de Barros e
; Foernges, Rafael
; Gomes, Rafael
; Moraes, Rafael
; Nonato filho, Raimundo
; Borba, Renato Luis
; Gomes, Renato V
; Cordioli, Ricardo
; Lima, Ricardo
; López, Ricardo Pérez
; Gargioni, Ricardo Rath de Oliveira
; Rosenblat, Richard
; Souza, Roberta Machado de
; Almeida, Roberto
; Narciso, Roberto Camargo
; Marco, Roberto
; waltrick, Roberto
; Biondi, Rodrigo
; Figueiredo, Rodrigo
; Dutra, Rodrigo Santana
; Batista, Roseane
; Felipe, Rouge
; Franco, Rubens Sergio da Silva
; Houly, Sandra
; Faria, Sara Socorro
; Pinto, Sergio Felix
; Luzzi, Sergio
; Sant’ana, Sergio
; Fernandes, Sergio Sonego
; Yamada, Sérgio
; Zajac, Sérgio
; Vaz, Sidiner Mesquita
; Bezerra, Silvia Aparecida Bezerra
; Farhat, Tatiana Bueno Tardivo
; Santos, Thiago Martins
; Smith, Tiago
; Silva, Ulysses V. A.
; Damasceno, Valnei Bento
; Nobre, Vandack
; Dantas, Vicente Cés de Souza
; Irineu, Vivian Menezes
; Bogado, Viviane
; Nedel, Wagner
; Campos Filho, Walther
; Dantas, Weidson
; Viana, William
; Oliveira Filho, Wilson de
; Delgadinho, Wilson Martins
; Finfer, Simon
; Machado, Flavia Ribeiro
.
RESUMO Objetivo: Descrever as práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras e compará-las com as de outros países participantes do estudo Fluid-TRIPS. Métodos: Este foi um estudo observacional transversal, prospectivo e internacional, de uma amostra de conveniência de unidades de terapia intensiva de 27 países (inclusive o Brasil), com utilização da base de dados Fluid-TRIPS compilada em 2014. Descrevemos os padrões de ressuscitação volêmica utilizados no Brasil em comparação com os de outros países e identificamos os fatores associados com a escolha dos fluidos. Resultados: No dia do estudo, foram incluídos 3.214 pacientes do Brasil e 3.493 pacientes de outros países, dos quais, respectivamente, 16,1% e 26,8% (p < 0,001) receberam fluidos. A principal indicação para ressuscitação volêmica foi comprometimento da perfusão e/ou baixo débito cardíaco (Brasil 71,7% versus outros países 56,4%; p < 0,001). No Brasil, a percentagem de pacientes que receberam soluções cristaloides foi mais elevada (97,7% versus 76,8%; p < 0,001), e solução de cloreto de sódio a 0,9% foi o cristaloide mais comumente utilizado (62,5% versus 27,1%; p < 0,001). A análise multivariada sugeriu que os níveis de albumina se associaram com o uso tanto de cristaloides quanto de coloides, enquanto o tipo de prescritor dos fluidos se associou apenas com o uso de cristaloides. Conclusão: Nossos resultados sugerem que cristaloides são usados mais frequentemente do que coloides para ressuscitação no Brasil, e essa discrepância, em termos de frequências, é mais elevada do que em outros países. A solução de cloreto de sódio 0,9% foi o cristaloide mais frequentemente prescrito. Os níveis de albumina sérica e o tipo de prescritor de fluidos foram os fatores associados com a escolha de cristaloides ou coloides para a prescrição de fluidos.
Abstract Objective: To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods: This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results: On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion: Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation.
https://doi.org/10.5935/0103-507x.20210028
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12.
Odontadenia lutea (Apocynaceae) LEAVES: PHYTOCHEMICAL STUDY AND INSECTICIDAL ACTIVITY AGAINST LEAF-CUTTING ANTS Atta sexdens rubropilosa Forel
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Silva Junior, Weber M. da
; Santos, Renato G.
; Duarte, Geane K. G. F.
; Cunha, Gracielle O. S.
; Silva, Daniela M. da
; Marchesin, Thais F. R.
; Bueno, Odair C.
; Menezes, Antônio Carlos S.
.
The present work describes the chemical constituents of Odontadenia lutea (Vell.) Markgr. leaves and the toxicities of its extract and fractions against Atta sexdens rubropilosa Forel (Hymenoptera: Formicidae). Chromatographic procedures of the ethanolic extract resulted in the identification of the triterpene β-amyrin, the flavonoid rutin, two fatty acids palmitic and linolenic, and one glyceroglycolipid 3-O-(9,12,15-octadecatrienoyl)-glyceryl-β-D-galactopyranoside, which are known compounds, but they are described for the first time in the Odontadenia genus. The known triterpenes lupeol and α-amyrin were also identified. Structural identification of the compounds was performed by analysis of IR, ESI-MS, and 1D and 2D NMR spectra. The toxicity of its extract and fractions from O. lutea leaves was tested against leaf-cutting ants Atta sexdens rubropilosa Forel by employing ingestion bioassay procedures. The hexane fraction (2 mg mL-1) decreases the average survival of ants from sixteen to six days, causing 98% mortality on the 14th day and 100% at the end of the experiment.
https://doi.org/10.21577/0100-4042.20170641
176 downloads
13.
Use of blend based on an emulsifier, monolaurin, and glycerides of butyric acid in the diet of broilers: impacts on intestinal health, performance, and meat
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ALMEIDA, AMANDA B.
; ARAÚJO, DENISE N.
; STRAPAZZON, JOÃO V.
; RITA, CLEICIANE
; DILDA, AMANDA
; BALEN, GIOVANA
; DEOLINDO, GUILHERME L.
; NESI, DANIELA
; FURLAN, VALCENIR J.M.
; PELISSER, GIOVANA
; MENDES, RICARDO E.
; FRACASSO, MATEUS
; WAGNER, ROGER
; BOIAGO, MARCEL M.
; SILVA, ALEKSANDRO S. DA
.
Abstract The objective of this study was to evaluate whether the addition of a blend based on α-monolaurin mono-, di- and triglycerides of butyric acid, and lysolecithin on the performance even on diets containing reduced inclusion of oil in the diet and without the use of growth-promoting antibiotics of broilers considering the effect on health, performance, and meat. Three treatments were defined: positive control (TP: with enramycin), negative control (TN: no enramycin), and blend (T-FRA: with monolaurin and glycerides of acid butyric minus 0.8% soybean oil). At 21 days, broilers treated with TP and T-FRA obtained the lower feed conversion ratio (FC); at 35 days, T-FRA broilers obtained lower FC than TN broilers. Cholesterol levels were higher in the blood of T-FRA broilers. On day 42, levels of ROS and TBARS were lower in the intestine, muscles, and liver of T-FRA broilers. Moreover, glutathione S-transferase and total non-enzymatic antioxidants were greater at the intestinal and muscular levels. The T-FRA broilers had a lower percentage of lipids in the meat. The MIC indicated that 111mg of the blend/mL inhibited the growth of E. coli; however, the counts of total coliforms and E. coli in the feces and the broilers’ litter did not differ between treatments. In conclusion, the addition of the blend T-FRA in broiler diets was able to improve the feed conversion and maintain the other performance parameters even considering a reduction of 0.8% in the inclusion of oil.
https://doi.org/10.1590/0001-3765202120210687
1 downloads
14.
Gender-related differences in the modulation of anthropometric, biochemical, and immune markers by physical activity in hypertensive and diabetic individuals
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SANTOS, DÉBORAH C. DOS
; RIBEIRO, ISRAEL S.
; LOPES, DIEGO PATRICK S.
; PEREIRA, ÍTALO S.
; SANTOS, DENISAR P.
; MUNIZ, IGOR P.R.
; LIMA, FERNANDA M. DA SILVA
; COSTA, ANDRESSA ANTÔNIA S.
; SOUZA, DANIELA DA SILVA P.
; CALADO, STÉFANO PEDRO DE MELO
; GONÇALVES, CAROLINE V.
; GALANTINI, MARIA POLIANA L.
; LOPES, DANILO N.
; SILVA, ROBSON A.A. DA
; SANTOS, GILVANÉIA S.
.
Abstract Systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM) compose the two major noncommunicable chronic inflammatory diseases. Physical activity has been shown as a promising complementary approach to control the systemic inflammation. However, it is still unclear whether this modulation is gender-dependent. The objective of this study was evaluate the gender-related influence of physical activity on the inflammatory response and biochemical profile of individuals with SAH and T2DM. An international physical activity questionnaire was applied to 376 individuals diagnosed with SAH and T2DM in order to access their exercises routine and was evaluated the influence of physical activity in biochemical, anthropometrical, and immunological markers involved in these disorders in men and women. Even though active individuals have exhibited lower serum levels of IL-1β, IFN-γ, TNF-α, and IL-17A, the ratios between IL-10 and all inflammatory cytokines were higher in men than in women. Physically active individuals also demonstrated increased HDL/LDL and HDL/VLDL ratios. Moreover, multiple correlations revealed that in active women both IL-10 and TNF-α serum levels positively correlate with fasting glucose levels, and were negatively associated with HDL levels. Our findings suggest that gender-related differences dictate a distinct crosstalk between inflammatory and biochemical markers in physically active individuals.
https://doi.org/10.1590/0001-3765202120201905
1 downloads
15.
Association between circulating exhausted CD4+ T cells with poor meningococcal C conjugate vaccine antibody response in HIV-infected children and adolescents
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Silva, Giselle P.
; Pereira-Manfro, Wania F.
; Costa, Priscilla R.
; Costa, Dayane A.
; Ferreira, Bianca
; Barreto, Daniela M.
; Frota, Ana Cristina C.
; Hofer, Cristina B.
; Figueredo, Carlos M.
; Coelho, Barbara
; Kallas, Esper G.
; Milagres, Lucimar G.
.
OBJECTIVES: To investigate the expression levels of surface markers of activation (CD38 and HLA-DR), inhibition (PD-1, TIGIT and CD57) and co-stimulation (CD28 and CD127) on CD4+ T cells of children/adolescents with vertical HIV infection (HI patients) and HIV-uninfected (HU) controls vaccinated with the meningococcal C conjugate vaccine (MCC). METHODS: HI patients (n=12), aged 8-17 years, were immunized with two MCC injections, while HU controls (n=9), aged 5.3-10.7 years, received a single MCC dose (as per national recommendation at the time of this study, a single MCC vaccine dose should be given for healthy children and youth aged 1-18 years). The HI patients were categorized according to the combined antiretroviral therapy (cART) treatment. Blood samples were obtained before vaccination, after priming, and after the administration of a booster dose of vaccine to determine the serum bactericidal antibody (SBA) titers and the expression levels of surface markers on CD4+ T cells by flow cytometry. The levels of serum cytokines, IL-4 and CXCL-13 were also measured using Luminex kits. RESULTS: The co-expression of the TIGIT-HLA-DR-CD38 molecules increased in the CD4+ T cells of HI patients/no-cART who also showed a lower frequency of CD127+CD28+ CD4+ T cells than HI patients/cART and HU group subjects. There were significant negative correlations between the frequency of exhausted CD4+ T cells and the SBA response. IL-4 levels were higher in HI patients/cART and positively correlated with SBA titers but negatively associated with the expression of exhaustion markers. Moreover, the CXCL-13 levels were positively correlated with the exhausted CD4+ T cells. CONCLUSION: The results of our study suggest that the co-expression of exhaustion markers and/or loss of co-stimulatory molecules influence the SBA response in HI patients.
https://doi.org/10.6061/clinics/2021/e2902
127 downloads
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