Resumo O cancro da mama é a doença maligna mais frequentemente diagnosticada nas mulheres em todo o mundo, com incidência e mortalidade crescentes, pelo que o conhecimento dos seus fatores de risco é de grande importância para se poder investir em medidas de prevenção primária eficazes. O contracetivo oral combinado (COC) é o método contracetivo mais utilizado em mulheres em idade fértil, com utilização média de 5 anos. Esta revisão sistemática pretende avaliar se existe maior incidência de cancro da mama em mulheres em idade fértil com exposição a COC superior a 5 anos, comparativamente a exposição inferior a 5 anos.

Abstract Breast cancer is the most frequently diagnosed malignant disease in women worldwide, with increasing incidence and mortality, therefore the knowledge of its risk factors is of great importance to be able to invest in effective primary prevention measures. The combined oral contraceptive (COC) is the most widely used contraceptive method in women of childbearing age, with an average use of 5 years. This systematic review aims to assess whether there is a higher incidence of breast cancer in women of childbearing age with exposure to COC for more than 5 years, compared to less than 5 years of exposure.

This study presents a comparative analysis between the North American short story The Story of an Hour (1894), by Kate Chopin, and the Brazilian novel A Hora da Estrela (1977), by Clarice Lispector. The objective was to comparatively analyze the works, focusing on the constitution of the characters Mrs. Mallard and Macabéa in the narrative. The study is anchored in the theoretical assumptions of Comparative Literature (LC), addressed by Carvalhal (2006), as well as by the studies by Candido (2000,2002), Gancho (2002), Compagnon (2001) and Bakhtin (1997), with regard to literature and narrative structures. It was based on a qualitative/interpretative research Gil (1999), directed in the light of CL, exploring the excerpts of the narratives and presenting the necessary discussions. Furthermore, it is considered that this work results from literature as a humanizing function and that it contributes to comparative literary studies, uniting reflections from different cultures, countries and languages ​​through the analysis of the literary text.

Este estudo apresenta uma análise comparativa entre o conto norte-americano The Story of an Hour (1894), escrito por Kate Chopin, e o romance brasileiro A Hora da Estrela (1977), de autoria de Clarice Lispector. O objetivo principal é analisar, de maneira comparativa, as duas obras, com foco na construção das personagens Mrs. Mallard e Macabéa ao longo da narrativa. O estudo está ancorado nos pressupostos teóricos da Literatura Comparada (LC), conforme Carvalhal (2006). Além disso, também nos apoiamos nos estudos de Candido (2000, 2002), Gancho (2002), Compagnon (2001) e Bakhtin (1997), especialmente no que diz respeito à literatura e às estruturas narrativas. Metodologicamente é uma pesquisa de cunho qualitativa e interpretativa Gil (1999), direcionada à luz da Literatura Comparada, explorando os trechos das narrativas e apresentando discussões necessárias. A análise desempenhada aponta para literatura enquanto função humanizadora e que contribui para os estudos literários comparativos, unindo reflexos a partir de culturas, países e línguas diferentes por meio da análise do texto literário.

Resumen En la región semiárida de Paraíba, el caupí es el principal producto de la agricultura familiar. El cultivo tiene baja productividad debido a lluvias irregulares y condiciones climá ticas desfavorables. Además, la productividad también se ve afectada por el uso deficiente de las tecnologías de producción. Con el objetivo de superar estas limitaciones y aumentar la eficiencia de la selección de cultivares superiores, se llevó a cabo un extenso estudio utili zando modelos biométricos en caupí. Este primer trabajo tuvo los siguientes objetivos: i. Cuantificar los efectos directos e indirectos de los componentes primarios y secundarios en la producción de granos; ii. Identificar variables con mayor potencial para la selección de cultivares de caupí en la región semiárida de Paraíba y iii. Determinar las estrategias de selección más adecuadas para el conjunto de variables evaluadas. El experimento se llevó a cabo en un campo experimental en el Centro de Ciencia y Tecnología Agroalimentaria de la Universidad Federal de Campina Grande. Se evaluó la influencia de 6 componentes primarios y 6 componentes secundarios de la producción sobre la variable rendimiento de grano. Los datos se sometieron a ANAVA y se estimaron parámetros genéticos. También se realizaron correlaciones y análisis de ruta. Se identificaron variables con mayor potencial para la selección de cultivares superiores de caupí en la región semiárida de Paraíba. Se encontró que la variable rendimiento de vaina es la más prometedora para la selección de cultivares con mayor rendimiento de grano debido a la magnitud de los efectos fenotípico y genotípico. La selección directa y la selección simultánea son las estrategias más adecuadas para el conjunto de variables evaluadas. Sin embargo, para maximizar las ganancias gené ticas, se continuó el estudio a través de índices de selección.

Abstract In the semi-arid region of Paraíba, cowpea has low productivity due to irregular rainfall and poor use of production technologies. An extensive study aimed at selecting more productive cultivars was conducted using biometric models. This first work had the following objectives: i. Quantify direct and indirect effects of primary and secondary compo nents on grain production; ii. Identify variables with greater potential for cultivar selection in the semiarid region of Paraíba and iii. Determine the most appropriate selection strat egies for the evaluated variables. The experiment was conducted in an experimental field. The influence of 6 primary and 6 secondary production components was evaluated on grain yield. Data were subjected to ANOVA. Genetic parameters, correlations and path analysis were estimated. Given the strong direct phenotypic and genotypic effects, pod yield results the most promising variable for higher grain yield selection. Direct and simultaneous selec tions are the most suitable strategies for the set of evaluated variables. However, further studies on selection indices are necessary to maximize genetic gains.

Resumen En la región semiárida de Paraíba, el caupí (Vigna unguiculata (L.) Walp) es el prin cipal producto de la agricultura familiar. El cultivo tiene baja productividad debido a lluvias irregulares y al uso de cultivares de baja productividad. Con el objetivo de superar estas limitaciones y aumentar la eficiencia de la selección de cultivares superiores, se llevó a cabo un extenso estudio utilizando modelos biométricos en caupí, con los siguientes obje tivos: i. Estimar las ganancias genéticas de los componentes de la producción; ii. Identi ficar el modelo de índice de selección que proporciona las mayores ganancias mediante la selección simultánea de un conjunto de variables y iii. Seleccionar cultivares con mayor productividad. El experimento se llevó a cabo en el campo experimental del Centro de Ciencia y Tecnología Agroalimentaria de la Universidad Federal de Campina Grande. Se evaluaron 13 variables relacionadas con la productividad. Los datos se sometieron a ANOVA y las medias se agruparon según la prueba de Scott y Knott p≤ 0,05. También se estimó el coeficiente de heredabilidad de cada variable. Las ganancias genéticas se estimaron utili zando las siguientes metodologías: respuesta correlacionada, índice de selección clásico, suma de rango e índice basado en las ganancias deseadas. Se encontró que la selección directa del componente de rendimiento de la vaina secundaria proporciona ganancias genéticas significativas en rendimiento de grano. Entre las metodologías utilizadas, el índice de selección clásico proporcionó una mayor distribución de las ganancias genéticas para rendimiento de grano y para los componentes primarios de producción. Estos resultados permiten concluir que los cultivares Costela de vaca, BRS Marataoã y Paulistinha pueden seleccionarse para cultivo y explotación en la región semiárida de Paraíba.

Abstract Low cowpea productivity (Vigna unguiculata (L.) Walp) in the semi-arid region of Paraíba is due, among other factors, to poor-quality cultivars. This research tested biometric models intending to increase productivity of superior cultivars with the following objectives: i. Estimate genetic gains in production components; ii. Identify the selection index model providing the greatest gains through simultaneously selecting a set of variables, and iii. Select cultivars with higher productivity. The experiment was carried out in the experimental field of the Agrifood Science and Technology Center of the Federal University of Campina Grande. Eight cultivars and 13 variables were evaluated. Data were subjected to ANOVA and means were grouped using the Scott and Knott test. Genetic gains were estimated by correlated response, classic selection index, rank sum and index based on desired gains. Direct selection of the secondary pod yield component provides significant genetic gains in main grain yield. Among the methodologies used, the classic selection index provided greater distribution of genetic gains for main grain yield and primary production components. These results allow concluding that Costela de vaca, BRS Marataoã and Paulistinha cultivars should be selected for cultivation and commercial exploitation in the semiarid region of Paraíba.

Abstract This study aimed to detect, quantify and compare the immunohistochemical expression of EGFR and VEGF and microvessel count (MVC) in oral lipomas, and to correlate the findings with clinical and morphological characteristics of the cases studied. The sample consisted of 54 oral lipomas (33 classic and 21 non-classic) and 23 normal adipose tissue specimens. Cytoplasmic and/or nuclear immunohistochemical staining of EGFR and VEGF was analyzed. The angiogenic index was determined by MVC. Cells were counted using the Image J® software. The Statistical Package for the Social Sciences was used for data analysis, adopting a level of significance of 5% for all statistical tests. A statistically significant difference in EGFR immunoexpression (p=0.047), especially, between classic lipomas and normal adipose tissue. There was a significant difference in MVC between non-classic lipomas and normal adipose tissue (p=0.022). In non-classic lipomas, only VEGF immunoexpression showed a significant moderate positive correlation (r=0.607, p=0.01) with MVC. In classic lipomas, the number of EGFR-immunostained adipocytes was directly proportional to the number of VEGF-positive cells, demonstrating a significant moderate positive correlation (r=0.566, p=0.005). The results suggest that EGFR, VEGF, and angiogenesis participate in the development of oral lipomas but are not primarily involved in the growth of these tumors.

Resumo Lipomas são as neoplasias mesenquimais benignas mais comuns, no entanto sua etiopatogenia ainda permanece desconhecida. Dessa forma, essa pesquisa teve como objetivo detectar, quantificar e comparar a expressão imunoistoquímica do EGFR, VEGF e contagem microvascular (MVC) dos lipomas orais, relacionando-os com as características clínicas e morfológicas dos casos estudados. A amostra foi composta por 54 lipomas orais (33 clássicos e 21 não clássicos) e 23 casos de tecido adiposo normal. A análise da expressão imunoistoquímica de EGFR e VEGF foi fundamentada na marcação citoplasmática e/ou nuclear. O índice angiogênico foi avaliado por meio da MVC. A contagem de células foi realizada utilizando software IMAGE J®. Os dados obtidos foram analisados no software Statistical Package for Social Science. O nível se significância de 5% foi adotado para os testes estatístico. A análise da imunoexpressão das proteínas revelou para o EGFR diferença estatisticamente significativa (p=0,041) entre o lipoma clássico e o tecido adiposo normal. Houve diferença significativa na MVC entre lipomas não clássicos e tecido adiposo normal (p=0,022). Nos lipomas não clássicos, apenas a imunoexpressão de VEGF apresentou correlação do tipo moderada, positiva e significativa (r=0,607; p=0,010) em relação a MVC. Ademais, nos lipomas clássicos foi percebido que os adipócitos imunomarcados para EGFR estiveram diretamente proporcionais a imunoexpressão de VEGF, apresentando correlação do tipo moderada, positiva e estatisticamente significativa (r=0,566; p = 0,005). Com base nos resultados, pode-se sugerir que o EGFR, VEGFR e MCV participam do desenvolvimento nos lipomas orais, contudo, não estão primariamente envolvidos no crescimento tumoral dessas neoplasias.

ABSTRACT. The objective was to assess the physiological and behavioral variables of pasture-raised Holstein heifers on the basis of their coat color. Eight heifers were used, four with black coat, and four with white coat. In the morning and afternoon periods, their physiological variables were measured, namely respiratory rate (RR, mov min. -1), rectal temperature (TR, ºC), and coat surface temperature (TS, ºC). The behavior analysis considered the site (sun or shade), position (standing or lying down), and activities (idleness, rumination, grazing, and others). The data of the physiological variables were assessed through analysis of variance, and significance, through Tukey’s test at 5%, while behavioral data were assessed using the Chi-squared test (SAS Software). There was a difference for all of the heifers’ physiological variables as a function of coat color (p < 0.0001) and period (p < 0.0001), with black ones showing greater results than white ones as to all physiological variables in the afternoon period (p < 0.0001). Grazing behavior is reduced during the hottest hours of the day. We conclude that solar radiation changes the physiological variables and grazing behavior of pasture-raised Holstein heifers.

Abstract The objective of the study was to determine whether Parkia platycephala families with superior morphophysiological traits perform consistently across four stages of early development (plantlets, seedlings, and juveniles at 34 and 60 months), as a means to assess the possibility of conducting pre-selection. For 21 morphophysiological traits, the following genetic parameters were estimated: heritability, coefficients of variation (genetic, relative, and environmental), accuracy, genetic and phenotypic correlation, percentage of coincidence (PC) of the best families, effective population size, and inbreeding in three progeny tests conducted under laboratory, nursery, and field conditions. Families of P. platycephala showed significant phenotypic and genotypic differences. The traits evaluated show genetic control. The percentage of coincidence between the best families was more accurate when the selection intensity was greater than 50% (PC ≥ 52%). Based on the evaluated traits, a pre-selection strategy at the juvenile stage for P. platycephala was researched to effectively identify superior families.

ABSTRACT Parkia platycephala, known commonly as faveira, is a native species that occurs widely throughout Brazil and has high nutritional value and ecological potential. The objective of this study was to estimate the genetic variability in a P. platycephala provenance and progeny test. The test was established using a randomized block design, with 45 progenies from three provenances. The evaluated quantitative traits included height (HEI), diameter at ground level (DGL), and diameter below the first bifurcation (DFB). The data were submitted to Restricted Maximum Likelihood/Best Linear Unbiased Prediction (REML/BLUP) analysis, from which estimates of genetic parameters, genetic correlations, BLUPs, genetic gains, and effective population size were obtained. Estimates of individual narrow sense heritability ( h a 2) and within progeny heritability ( h w 2) ranged from low to moderate (0.01 a 0.39), with the highest values observed for DGL (0.32 and 0.39, respectively). The coefficient of individual variation (CVgi(%)) and between progeny genetic variation (CVgp(%)) indicate the existence of genetic variability between and within provenances. The FSTvalues demonstrate low to moderate genetic differentiation among the three populations, and genetic correlations between traits were all positive and significant. The results obtained show that there is genetic variability between the studied provenances and progenies. This ensures not only the ex situ conservation of the species, but it can also be exploited in breeding programs.

RESUMO Parkia platycephala, popularmente conhecida como faveira, é uma espécie nativa que ocorre amplamente em todo o Brasil e possui alto valor nutricional e potencial ecológico. Objetivou-se com o trabalho estimar a variabilidade genética em teste de procedências e progênies de P. platycephala. O teste foi instalado em blocos casualizados, com 45 progênies de três procedências. Os caracteres quantitativos avaliados foram: altura (ALT), diâmetro a nível do solo (DNS) e diâmetro a altura da primeira bifurcação (DAB) das plantas. Os dados foram submetidos à análise de REML/BLUP, a partir da qual foram obtidas as estimativas de parâmetros genéticos, correlações genéticas, os BLUP’s, ganhos genéticos e tamanho efetivo populacional. As estimativas de herdabilidade individual no sentido restrito ( h a 2) e dentro progênies ( h w 2) variaram de baixa a moderada (0,01 a 0,39), sendo os maiores valores observados para o caractere DNS (0,32 e 0,39, respectivamente). Os valores de coeficiente de variação genética individual CVgi(%)) e entre progênies (CVgp(%)) indicam existência de variabilidade genética entre e dentro de população. Os valores de FSTdemonstraram baixa a moderada diferenciação genética entre as três populações. As correlações genéticas entre os caracteres foram todas positivas e significativas. Os resultados obtidos mostram que há variabilidade genética entre as procedências e progênies estudadas. Isso garante não só a conservação ex situ da espécie, como também pode ser explorada em programas de melhoramento

Abstract Background: Several hemodynamic and respiratory variables measured during cardiopulmonary exercise testing (CPX) have been shown to predict survival. One such measure is the cardiorespiratory optimal point (COP) that reflects the best possible circulation-respiration interaction, but there are still limited data on its relationship with adverse outcomes. Objective: To assess the association between COP and cardiovascular mortality in men aged 46 to 70 years. Methods: A sample of 2201 men who had anthropometric, clinical, and COP data obtained during cycling CPX between 1995 and 2022 was extracted from the CLINIMEX Exercise cohort. COP was identified as the minimal minute-to-minute VE/VO2 during CPX. Vital data were censored on October 31, 2022 for ICD-10-identified cardiovascular deaths. Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs). Results: The mean ± standard deviation age was 57 ± 6 years and the median COP value was 24 (interquartile range = 21.2 to 27.4). During a mean follow-up of 4688 ± 2416 days, 129 (5.6%) patients died from cardiovascular causes. The death rates for low (< 28), high (28 to 30), and very high (> 30) categories of COP were 3.2%, 9.6%, and 18.7%, respectively. Following adjustment for age, history of myocardial infarction, diagnosis of coronary artery disease, and diabetes mellitus, the HR (95% CI) for cardiovascular mortality comparing very high versus low COP was 2.76 (1.87 to 4.07; p < 0.001). Conclusions: Our data indicate that, for a general population-based sample of men, COP > 30 represents a considerably higher risk for cardiovascular death. Information on COP could assist cardiovascular risk assessment in men.

Abstract Background Rheumatoid arthritis is an autoimmune inflammatory disease that often leads patients to muscle impairment and physical disability. This study aimed to evaluate changes in the activity of proteasome system in skeletal muscles of mice with collagen-induced arthritis (CIA) and treated with etanercept or methotrexate. Methods Male DBA1/J mice were divided into four groups (n = 8 each): CIA-Vehicle (treated with saline), CIA-ETN (treated with etanercept, 5.5 mg/kg), CIA-MTX (treated with methotrexate, 35 mg/kg) and CO (healthy control group). Mice were treated two times a week for 6 weeks. Clinical score and hind paw edema were measured. Muscles were weighted after euthanasia and used to quantify proteasome activity, gene (MuRF-1, PMSα4, PSMβ5, PMSβ6, PSMβ7, PSMβ8, PSMβ9, and PSMβ10), and protein (PSMβ1, PSMβ5, PSMβ1i, PSMβ5i) expression of proteasome subunits. Results Both treatments slowed disease development, but only CIA-ETN maintained muscle weight compared to CIA-MTX and CIA-Vehicle groups. Etanercept treatment showed caspase-like activity of 26S proteasome similar to CO group, while CIA-Vehicle and CIA-MTX had higher activity compared to CO group (p: 0.0057). MuRF-1 mRNA expression was decreased after etanercept administration compared to CIA-Vehicle and CO groups (p: 0.002, p: 0.007, respectively). PSMβ8 and PSMβ9 mRNA levels were increased in CIA-Vehicle and CIA-MTX compared to CO group, while CIA-ETN presented no difference from CO. PMSβ6 mRNA expression was higher in CIA-Vehicle and CIA-MTX groups than in CO group. Protein levels of the PSMβ5 subunit were increased in CO group compared to CIA-Vehicle; after both etanercept and methotrexate treatments, PSMβ5 expression was higher than in CIA-Vehicle group and did not differ from CO group expression (p: 0.0025, p: 0.001, respectively). The inflammation-induced subunit β1 (LMP2) was enhanced after methotrexate treatment compared to CO group (p: 0.043). Conclusions The results of CIA-Vehicle show that arthritis increases muscle proteasome activation by enhanced caspase-like activity of 26S proteasome and increased PSMβ8 and PSMβ9 mRNA levels. Etanercept treatment was able to maintain the muscle weight and to modulate proteasome so that its activity and gene expression were compared to CO after TNF inhibition. The protein expression of inflammation-induced proteasome subunit was increased in muscle of CIA-MTX group but not following etanercept treatment. Thus, anti-TNF treatment may be an interesting approach to attenuate the arthritis-related muscle wasting.

ABSTRACT The fungus Fusarium verticillioides produces fumonisins (FB1 and FB2), characterized by being the most frequently produced molecular forms and with greater toxicity. Fumonisin contamination is responsible for substantial losses during the meat production chain, so the safe levels of these compounds must be determined. The study was directed to establish safe levels of FB1 in poultry production; for this purpose, were used COBB 500® birds on experimental lots of infected corn during the 2015/2016 season in Brazil. The experimental group included 160 animals, divided into two groups: The T1 without fumonisin in the diet (control); and the T2 group in which corn was contaminated with 2.78 μg/g of fumonisin FB1. Histopathological effects of liver, heart, and small intestine, and zootechnical parameters were measured in birds treated. We found that there were no significant differences between the birds treated and untreated after 21 days of exposure to each treatment; F-values > P-values (P<0,05) for feed intake and weekly weight gain. Taken together, our data showed that the concentration evaluated is safe in poultry and will contribute to the design of future clinical studies.

RESUMEN El hongo Fusarium verticillioides produce fumonisinas (FB1 y FB2), caracterizadas por ser las formas moleculares más frecuentemente producidas y con la toxicidad más significativa. La contaminación por fumonisinas es responsable de pérdidas sustanciales durante la cadena de producción de carne por lo que niveles seguros de estos compuestos deben ser determinados. Este estudio pretende establecer niveles seguros de FB1 en la producción avícola; para ello, se utilizaron aves COBB 500® en lotes experimentales de maíz infectado durante la temporada 2015/2016 en Brasil. El grupo experimental incluyó 160 animales, divididos en dos grupos: T1 sin fumonisinas en la dieta (control); y el grupo T2 en el que el maíz fue contaminado con 2,78μg/g de fumonisina FB1. Fueron medidos los efectos histopatológicos en hígado, corazón e intestino delgado y parámetros zootécnicos en aves tratadas. No se encontraron diferencias significativas entre las aves tratadas y el control después de 21 días de exposición, para consumo de alimento y ganancia de peso semanal. En conjunto, los resultados muestran que la concentración de FB1 evaluada es segura en aves de corral y contribuirán al diseño de futuros estudios clínicos.

RESUMO A perda da variabilidade genética de populações naturais implica negativamente no processo adaptativo e evolutivo das espécies. Nesse contexto, objetivou-se avaliar a variabilidade genética existente entre e dentro de populações naturais de P. platycephala, a partir de caracteres biométricos de frutos e sementes e fisiológicos de sementes e plântulas, e assim, verificar o potencial para seleção de árvores matrizes e indicar áreas para coleta e uso de sementes, como também gerar subsídios para conservação e pré-melhoramento genético da espécie. O delineamento experimental utilizado foi o inteiramente casualizado, com 45 tratamentos (progênies) e quatro repetições de 25 sementes cada. As progênies foram avaliadas em laboratório, a partir de sementes coletadas de 45 matrizes amostradas em três populações naturais. Para tanto, avaliou-se os seguintes caracteres: porcentagem de germinação, índice de velocidade de germinação, tempo médio de germinação, comprimento de parte aérea e raiz principal, massa seca da parte aérea e do sistema radicular de plântulas. Os dados foram submetidos a análise RELM/BLUP para estimativa dos parâmetros genéticos, correlações e análises de divergência genética (UPGMA). As populações apresentam diferenças genéticas entre si, e variação significativa entre progênies para todos os caracteres avaliados, sendo maior a variação dentro do que entre populações. Os caracteres avaliados apresentam alto controle genético, portanto, estes podem ser utilizados na análise da variabilidade genética de populações e progênies de P. platycephala, auxiliando assim na identificação de áreas para a coleta de sementes, programas de conservação e pré-melhoramento genético da espécie.

ABSTRACT Loss of genetic variability in natural populations affects negatively the adaptive and evolutive process of plant species. In this context, the objective of this work was to evaluate the existing genetic variability between and within natural populations of P. platycephala, using biometric characters of fruits and seeds and physiological characters of seeds and seedlings, and, thus, assess the potential for selection of mother trees, indicate areas for seed collection and use, and generate support for conservation and pre-breeding of plant species. A completely randomized experimental design was used, with 45 treatments (progenies) and four replications of 25 seeds. The progenies were evaluated in laboratory, using seeds collected from 45 mother trees sampled in three natural populations. The following characters were evaluated: seed germination percentage, germination speed index, and mean germination time; shoot and main root lengths; and seedling shoot and root dry weights. The data were subjected to RELM/BLUP analysis for estimating genetic parameters and correlations and to analyses of genetic divergence (UPGMA). The populations present genetic differences to each other and a significant variation between progenies for all characters evaluated, and the variation was greater within the populations. The characters evaluated present high genetic control; therefore, they can be used in analysis of genetic variability of populations and progenies of P. platycephala, thus assisting in the identification of areas for seed collection, conservation programs, and pre-breeding of the species.

Resumo: O “marxismo cultural” tem sido usado como justificativa para o ataque ao pensamento social crítico em todo o mundo. O ensino superior, como local de produção do conhecimento, não tem ficado de fora deste ataque e vem sendo alvo nos últimos anos no Brasil com maior força desde o início do governo Bolsonaro. Assim, este artigo visa apresentar uma proposta de Revisão Sistemática Crítica sobre a relação entre o ‘marxismo cultural’ e o ensino superior. Trata-se de uma revisão sistemática crítica da literatura sobre o tema presente em periódicos marxistas. Optamos pelo método de revisão sistemática, adaptando suas etapas à área do conhecimento científico marxista. Foram identificadas 32 revistas científicas reconhecidamente marxistas. Os “termos livres primários” para elaborar uma estratégia de busca foram ‘ensino superior’, ‘marxismo cultural’ e ‘guerra cultural’ e os “termos livres secundários” usados foram ‘Escola de Frankfurt, ‘bolchevismo’ e ‘conservadorismo’. Como resultado, obtiveram-se 563 publicações. Após a utilização do fluxograma PRISMA, 35 artigos foram incluídos para revisão. A análise dos dados extraídos dos 35 artigos incluídos será realizada por meio da Análise Crítica de Conteúdo e a interpretação será feita pelo método do materialismo histórico dialético. Nesta adaptação foi preciso considerar aos diferentes sistemas internos de busca de cada revista e suas limitações. Uma hipótese é que essas dificuldades possam ser decorrentes do interesse de que o conhecimento marxista esteja fora do debate, e, uma forma de fazer isso, é dificultar sua recuperação na internet. Pensamos que o caminho de busca apresentado neste artigo possa ajudar outros pesquisadores interessados no debate marxista a encontrar periódicos e utilizar uma forma sistemática para facilitar a reprodutibilidade do caminho a ser seguido.

Abstract: “Cultural Marxism” has been used as a justification for the attack on critical social thought around the world. Higher education, as a place of knowledge production, has not been left out of this attack and has been targeted in recent years in Brazil with greater force since the beginning of the Bolsonaro government. Thus, this article aims to present a proposal for a Critical Systematic Review on the relationship between 'cultural Marxism' and higher education. This is a systematic critical review of the literature on the topic present in Marxist journals. We opted for the systematic review method, adapting its steps to the area of Marxist scientific knowledge. Thirty-two recognizably Marxist scientific journals were identified. The "primary free terms" used to create a search strategy were 'higher education', 'cultural Marxism' and 'culture warfare' and the "secondary free terms" used were 'Frankfurt School, 'Bolshevism' and 'conservatism'. As a result, 563 publications were obtained. After using the PRISMA flowchart, 35 articles were included for review. The analysis of the data extracted from the 35 articles included will be carried out through Critical Content Analysis and the interpretation will be made by the method of dialectical historical materialism. In this adaptation, it was necessary to consider the different internal search systems of each journal and their limitations. One hypothesis is that these difficulties may be due to the interest that Marxist knowledge is out of the debate, and one way to do this is to make it difficult to retrieve it on the internet. We think that the search path presented in this article can help other researchers interested in the Marxist debate to find journals and use a systematic way to facilitate the reproducibility of the path to be followed.

RESUMO A intensificação da agropecuária na Amazônia ameaça a manutenção da biodiversidade, interfere na ciclagem da água e nos estoques de carbono, alterando os ciclos biogeoquímicos em escala local e regional. Recentemente, na Amazônia, políticas públicas têm sido criadas para promover o desenvolvimento sustentável, tal como observado com o Plano Nacional de Produção e uso do Biodiesel (PNPB) em 2005, e o Programa de Produção Sustentável de Óleo de Palma (PPSOP) em 2010, facilitando a entrada de alguns municípios do nordeste paraense na cadeia produtiva da palma de óleo (dendê - Elaeis guineensis Jacq.). Assim, o objetivo deste trabalho é quantificar a cobertura vegetal e o uso da terra para avaliar a qualidade ambiental do município de Mãe do Rio no Pará, para os anos de 2008 e 2016. A metodologia inclui revisão bibliográfica, análise espacial/temporal da cobertura e uso da terra e o Índice de Transformação Antrópica (ITA). Os resultados demonstram que as principais mudanças ocorridas em 2008 e 2016 são: i. o desmatamento contínuo das florestas primárias, enquanto a floresta secundária aumenta em área; ii. a expansão gradual dos dendezeiros sobre as áreas de agropecuária; iii. o aumento da área de solo exposto indica uma alta rotatividade do uso e cobertura da terra; iv. em 2008 e 2016, os índices são 7,56 e 7,64 respectivamente, considerados “potencialmente insustentáveis”, devido à continua supressão de floresta primária, degradada e campinaranas, favorecendo a perda da biodiversidade na região, condição que justifica o apoio à política da dendeicultura.

ABSTRACT The intensification of agriculture in the Amazon threatens the maintenance of biodiversity, interferes with water cycling and carbon stocks, altering biogeochemical cycles on a local and regional scale. Recently, in the Amazon, public policies have been created to promote sustainable development, as observed with the National Plan for the Production and Use of Biodiesel (PNPB) in 2005 and the Sustainable Palm Oil Production Program (PPSOP) in 2010, facilitating the entry of some municipalities in the northeast of Pará to the oil palm productive chain (oil palm - Elaeis guineensis Jacq.). Thus, the objective is to quantify the vegetation cover and land use to assess the environmental quality of the municipality of Mãe do Rio in Pará for the years 2008 and 2016. The methodology includes bibliographic review, spatial/temporal analysis of the coverage and use of land, and the Anthropic Transformation Index (ITA). The results show that the main changes that occurred in 2008 and 2016 are: i. the continuous deforestation of primary forests, while the secondary forest increases in area; ii. the gradual expansion of oil palm over agricultural areas; iii. the increase in the area of exposed soil indicates a high turnover in land use and coverage; iv. in 2008 and 2016, the indexes are 7.56 and 7.64 respectively, considered “potentially unsustainable,” due to the continuous suppression of primary, degraded and campinaranas forests, favoring the loss of biodiversity in the region, a condition that justifies support for oil palm.

Abstract Odontomas are the most common tumor-like (hamartoma) odontogenic lesions in the gnathic bones. There are two main types: complex odontoma which is composed mainly of amorphous calcification, and compound odontoma which is characterized by irregular tooth-like structures. Odontomas are generally asymptomatic and in most cases involve only one quadrant of the maxilla or mandible. The treatment of choice is surgical removal. The aim of the present study is to report a rare case of multiple complex odontomas affecting the mandible and to review the literature on the clinical and pathological features of these tumors.

Resumo Odontomas são as lesões odontogênicas mais comuns nos ossos gnaticos mais comuns. Existem dois tipos principais: odontoma complexo que é composto principalmente de calcificação amorfa, e odontoma composto que é caracterizado por estruturas irregulares semelhantes à dentes. Odontomas são geralmente assintomáticos e, na maioria dos casos, envolvem apenas um quadrante da maxila ou mandíbula. O tratamento escolhido é a remoção cirúrgica.

Resumen Los odontomas son las lesiones odontogénicas más comunes en los huesos gnáticos más comunes. Hay dos tipos principales: odontoma complejo, que se compone principalmente de calcificación amorfa, y odontoma compuesto, que se caracteriza por estructuras irregulares similares a dientes. Los odontomas suelen ser asintomáticos y, en la mayoría de los casos, afectan solo un cuadrante del maxilar o la mandíbula. El tratamiento elegido es la extirpación quirúrgica.