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Abstract Background Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder. Objective The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience. Methods Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy. Results From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease. Conclusions Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.

Resumo Antecedentes Migrânea afeta um bilhão de pessoas em todo o mundo e mais de 30 milhões de brasileiros; além disso, é um distúrbio subdiagnosticado e subtratado. Objetivo Sabe-se sobre a necessidade de difundir o conhecimento sobre o tratamento profilático da migrânea; por isso, a Sociedade Brasileira de Cefaleias (SBCe) nomeou um comitê de autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da migrânea episódica com base em artigos da literatura mundial, assim como da experiência pessoal. Métodos As reuniões foram realizadas inteiramente online, com a participação de 12 grupos que revisaram e escreveram sobre as categorias farmacológicas dos medicamentos e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de medicamentos estudadas na parte II deste Consenso foram: anti-hipertensivos, inibidores seletivos de recaptação de serotonina, inibidores de recaptação de serotonina e noradrenalina, bloqueadores dos canais de cálcio, outros medicamentos e politerapia racional. Resultados Desta lista de medicamentos, apenas o candesartan foi estabelecido como eficaz no controle da migrânea episódica. Flunarizina, venlafaxina, duloxetina e pizotifeno foram definidos como provavelmente eficazes, enquanto lisinopril, enalapril, escitalopram, fluvoxamina, quetiapina, atorvastatina, sinvastatina, ciproheptadina e melatonina foram possivelmente eficazes na profilaxia da doença. Conclusões Apesar do esforço da comunidade científica em encontrarmedicamentos realmente eficazes no tratamento da migrânea, dado o grande número de medicamentos testados para este fim, ainda dispomos de poucas opções terapêuticas.

https://doi.org/10.1055/s-0042-1755320

Jóvenes universitarios de género masculino y el uso del preservativo
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Spindola, Thelma

; Fernandes-da Fonte, Vinícius Rodrigues

; Figueiredo-Lima, Giselle da Silva

; Costa-de Moraes, Paula

; Costa-Martins, Elizabeth Rose

; dos Santos-Soares, Barbara Galvão

Enfermería Global

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2022, Volume 21 N. 67 Pages 185 - 220

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO: Objetivo: Analisar o uso sistemático do preservativo por universitários do gênero masculino. Método: Estudo transversal realizado em duas instituições de ensino superior no Rio de Janeiro, com 661 estudantes de 18-29 anos, sexualmente ativos, que responderam um questionário. Os dados foram analisados com emprego do softwareStatistical Package for the Social Sciences através da estatística descritiva e inferencial, com a aplicação do teste qui-quadrado de Pearson. Resultados: Dados demonstram que os jovens são solteiros (61,98%); heterossexuais (87,37%); não usam preservativo com parcerias fixas (45,40%) ou eventuais (23,55%). A situação conjugal, orientação sexual, crença religiosa, uso de álcool e outras drogas antes da última relação sexual, percepção de risco e história pregressa de infecção sexualmente transmissível são fatores determinante para uso do preservativo (p-valor<0,05). Conclusão: Considerando as características próprias da juventude e fatores socioculturais envolvidos, nota-se que os estudantes assumem comportamentos de risco frente às infecções sexualmente transmissíveis com a utilização não sistemática do preservativo.

RESUMEN: Objetivo: Analizar el uso sistemático del condón por estudiantes universitarios varones. Método: Estudio transversal realizado en dos instituciones de educación superior de Río de Janeiro, con 661 estudiantes sexualmente activos de 18 a 29 años que respondieron un cuestionario. Los datos fueran analizados con el software Statistical Package for Social Sciences mediante estadística descriptiva e inferencial, con la aplicación de la prueba chi-cuadrado de Pearson. Resultados: Los datos muestran que los jóvenes son solteros (61,98%); heterosexuales (87,37%); no usan condones con parejas fijas (45,40%) o ocasionales (23,55%). El estado civil, la orientación sexual, las creencias religiosas, el consumo de alcohol y otras drogas antes de la última relación sexual, la percepción de riesgo y antecedentes de infecciones de transmisión sexual son un factor determinante para el uso del condón (valor de p <0,05). Conclusión: Considerando las características de la juventud y los factores socioculturales involucrados, se observa que los estudiantes asumen conductas de riesgo ante las infecciones de transmisión sexual con el uso no sistemático del condón.

ABSTRACT: Objective: to analyze systematic condom use by male university students. Method: A cross-sectional study carried out in two higher education institutions from Rio de Janeiro, with 661 sexually active students aged 18-29, who answered a questionnaire. The data were analyzed using the Statistical Package for Social Sciences software through descriptive and inferential statistics, with application of Pearson's chi-square test. Results: The data show that young people are single (61.98%), heterosexuals (87.37%) and that they do not use condoms with steady (45.40%) or occasional (23.55%) partners. Marital status, sexual orientation, religious belief, use of alcohol and other drugs before the last sexual relationship, risk perception and past history of sexually transmitted infections are determining factors for condom use (p-value<0.05). Conclusion: Considering the characteristics inherent to youth and the sociocultural factors involved, it is noted that the students assume risk behaviors in the face of sexually transmitted infections with non-systematic condom use.

https://doi.org/10.6018/eglobal.489491

Performance, body composition, and physiological response of tambaqui fed diet with green tea extract
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Corrêa, Carline Barroso

; Veras, Galileu Crovatto

; Silva, Giselle Paula Silva da

; Brabo, Marcos Ferreira

; Silva, Evaldo Martins

Pesquisa Agropecuária Brasileira

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may 2018, Volume 53 N. 5 Pages 540 - 546

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar o desempenho, a composição corporal e o estado fisiológico de alevinos de tambaqui (Colossoma macropomum), alimentados com dietas com diferentes teores de extrato de chá-verde (Camellia sinensis, ECV). Utilizou-se um delineamento inteiramente casualizado, com cinco tratamentos, diferentes níveis de ECV (0,00, 0,05, 0,30, 0,55 e 0,80 g kg-1) e três repetições. As dietas foram oferecidas aos alevinos duas vezes ao dia, por 90 dias. O aumento dos níveis de ECV na dieta promoveu um efeito quadrático positivo sobre lipídeo corporal, lipídeo hepático, retenção de lipídeo corporal, glicose e triglicerídeos totais, e os valores mínimos destas variáveis foram estimados com níveis de 0,61, 0,54, 0,73, 0,60 e 0,30 g kg-1 ECV na dieta, respectivamente. Houve efeito quadrático negativo sobre proteína corporal e hemoglobina, com o aumento dos níveis de ECV na dieta, e os valores máximos destas variáveis foram estimados com níveis de 0,59 e 0,46 g kg-1 ECV na dieta, respectivamente. Houve redução linear dos níveis de colesterol total, com o aumento dos níveis de inclusão do ECV na dieta. A inclusão de ECV na dieta, apesar de não influenciar o desempenho, reduz a gordura corporal e a do fígado; diminui o colesterol total, os triglicerídeos e a glicose; e promove o aumento da proteína corporal de alevinos de tambaqui, o que melhora a condição de saúde deste peixe, durante o cultivo, e a qualidade do produto final.

Abstract: The objective of this work was to evaluate the performance, body composition, and physiological state of tambaqui (Colossoma macropomum) fingerlings fed diets containing different levels of green tea (Camellia sinensis) extract (GTE). A completely randomized design was used with five treatments, different levels of GTE (0.00, 0.05, 0.30, 0.55, and 0.80 g kg-1) and three replicates. The diets were offered to fingerlings twice a day, for 90 days. The increase of dietary GTE levels promoted a positive quadratic effect on body lipids, hepatic lipids, retention of body lipids, glucose, and total triglycerides, and the minimum values of these variables were estimated with 0.61, 0.54, 0.73, 0.60, and 0.30g kg-1 GTE in the diet, respectively. There was a negative quadratic effect of the extract on body protein and hemoglobin with the increased GTE dietary level, and the maximum values of these variables were estimated with 0.59 and 0.46 g kg-1 GTE dietary level, respectively. Total cholesterol levels showed a linear reduction with increased GTE dietary level. The inclusion of GTE in the diet, although not affecting performance, decreases body and hepatic fat; reduces the levels of total cholesterol, triglycerides, and glucose; and promotes the increase of body protein of tambaqui fingerlings, improving fish health conditions, during cultivation, and the quality of the final product.

https://doi.org/10.1590/s0100-204x2018000500002 987 downloads

Clínica fonoaudiológica bilíngue, uma proposta terapêutica para surdos com a língua escrita: estudo de caso
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Guarinello, Ana Cristina

; Massi, Giselle

; Berberian, Ana Paula

; Tonocchi, Rita

; Lustosa, Sandra Silva

CoDAS

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oct 2015, Volume 27 N. 5 Pages 498 - 504

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: O objetivo deste estudo foi analisar produções escritas de um sujeito surdo em processo de apropriação da escrita. Métodos: Participou dessa pesquisa um sujeito surdo, reconhecido pela inicial R., em conjunto com a sua fonoaudióloga. Cabe esclarecer que tal profissional, proficiente em língua de sinais, atuou como interlocutora e intérprete, priorizando a natureza interativa da linguagem e interferindo nas produções escritas apenas quando solicitada. Resultados: Durante os três anos trabalhados com R., observou-se uma mudança de postura perante a língua escrita. Além disso, ele passou a refletir sobre seus textos e a utilizar a Língua Portuguesa de maneira que seus textos tornaram-se mais coerentes para os leitores. A escrita tornou-se, assim, um espaço a mais de manifestação da singularidade de R., que passou a reconstruir sua história de relação com a linguagem. Conclusão: O trabalho fonoaudiológico em uma clínica bilíngue, por meio do qual os surdos podem ter acesso precoce à língua de sinais, pode possibilitar o desenvolvimento da modalidade escrita da Língua Portuguesa.

ABSTRACT Purpose: This study aimed to analyze the written production of a deaf person who is in the process of written language acquisition. Methods: One person with hearing disability, called R., participated in this study together with his Speech Language Pathologist. The therapist, proficient in sign language, acted as an interlocutor and interpreter, prioritizing the interactive nature of language and interfering in the written production only when it was requested. Results: During the 3 years of work with R., a change in stance toward written language was observed. In addition, he began to reflect on his texts and utilize written Portuguese in a way that allowed his texts to be more coherent. Writing became an opportunity to show his singularity and to begin reconstructing his relationship with language. Conclusion: Speech language pathology and audiology therapy, at a bilingual clinic, can allow people with hearing disability early access to sign language and, consequently, enable the development of the written form of Portuguese.

https://doi.org/10.1590/2317-1782/20152015069 4795 downloads

Depression as a Clinical Determinant of Dependence and Low Quality of Life in Elderly Patients with Cardiovascular Disease
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Rodrigues, Giselle Helena de Paula

; Gebara, Otavio Celso Eluf

; Gerbi, Catia Cilene da Silva

; Pierri, Humberto

; Wajngarten, Mauricio

Arquivos Brasileiros de Cardiologia

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jun 2015, Volume 104 N. 6 Pages 443 - 449

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Fundamento:Com o envelhecimento, a prevalência de doenças crônico-degenerativas sofreu aumento progressivo. A repercussão dessas doenças sobre a capacidade funcional foi reconhecida. Outro parâmetro de saúde é a “qualidade de vida relacionada à saúde”. Na população idosa, as doenças cardiovasculares destacam-se pelo impacto epidemiológico e clínico. Elas, geralmente, vêm associadas a outras afecções. Esse conjunto de problemas pode comprometer a independência e a qualidade de vida do idoso que busca tratamento cardiológico.Objetivo:Avaliar, em uma população de idosos cardiopatas, quais são os determinantes clínicos mais relevantes de dependência e de qualidade de vida.Métodos:O grupo foi selecionado aleatória e consecutivamente, sendo aplicados quatro questionários: HAQ, SF-36, PRIME‑MD e Mini Exame do Estado Mental.Resultados:Incluiu-se 1020 idosos, 63,3% mulheres. O grupo tinha em média 75,56 ± 6,62 anos. 61,4% mostrou-se independente ou com dependência leve. O escore de qualidade de vida foi elevado (HAQ: 88,66 ± 2,68). 87,8% dos pacientes apresentou escore total do SF-36 ≥ 66. À análise multivariada, a associação entre os diagnósticos e graus elevados de dependência foi significante apenas para acidente vascular cerebral prévio (p = 0,014), obesidade (p < 0,001), sedentarismo (p = 0,016), osteoartrite (p < 0,001), déficit cognitivo (p < 0,001), e depressão maior (p < 0,001). Ao analisarmos a qualidade de vida, a depressão maior e a depressão por doença física associou-se significativamente com todos os domínios do SF-36.Conclusão:Em uma população de idosos cardiopatas, os determinantes clínicos mais relevantes de prejuízos para dependência e qualidade de vida foram as comorbidades não cardiovasculares, particularmente a depressão.

Background:The aging process promotes a progressive increase in chronic-degenerative diseases. The effect of these diseases on the functional capacity has been well recognized. Another health parameter concerns “quality of life related to health”. Among the elderly population, cardiovascular diseases stand out due to the epidemiological and clinical impact. Usually, these diseases have been associated with others. This set of problems may compromise both independence and quality of life in elderly patients who seek cardiologic treatment. These health parameters have not been well contemplated by cardiologists.Objective:Evaluating, among the elderly population with cardiovascular disease, which are the most relevant clinical determinants regarding dependence and quality of life.Methods:This group was randomly and consecutively selected and four questionnaires were applied: HAQ, SF-36, PRIME-MD e Mini Mental State.Results:The study included 1,020 elderly patients, 63.3% women. The group had been between 60 and 97 years-old (mean: 75.56 ± 6.62 years-old). 61.4% were independent or mild dependence. The quality of life total score was high (HAQ: 88.66 ± 2.68). 87.8% of patients had a SF-36 total score > 66. In the multivariate analysis, the association between diagnoses and high degrees of dependence was significant only for previous stroke (p = 0.014), obesity (p < 0.001), lack of physical activity (p = 0.016), osteoarthritis (p < 0.001), cognitive impairment (p < 0.001), and major depression (p < 0.001). Analyzing the quality of life, major depression and physical illness for depression was significantly associated with all domains of the SF-36.Conclusion:Among an elderly outpatient cardiology population, dependence and quality of life clinical determinants are not cardiovascular comorbidities, especially the depression.

https://doi.org/10.5935/abc.20150034 4408 downloads

Perimicrovillar membrane assembly: the fate of phospholipids synthesised by the midgut of Rhodnius prolixus
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Bittencourt-Cunha, Paula Rego

; Silva-Cardoso, Livia

; Oliveira, Giselle Almeida de

; Silva, Jose Roberto da

; Silveira, Alan Barbosa da

; Kluck, George Eduardo Gabriel

; Souza-Lima, Michele

; Gondim, Katia Calp

; Dansa-Petretsky, Marilvia

; Silva, Carlos Peres

; Masuda, Hatisaburo

; Silva Neto, Mario Alberto Cardoso da

; Atella, Georgia Correa

Memórias do Instituto Oswaldo Cruz

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jun 2013, Volume 108 N. 4 Pages 494 - 500

Abstract: En | Text: En | PDF: En

In this study, we describe the fate of fatty acids that are incorporated from the lumen by the posterior midgut epithelium of Rhodnius prolixus and the biosynthesis of lipids. We also demonstrate that neutral lipids (NL) are transferred to the haemolymphatic lipophorin (Lp) and that phospholipids remain in the tissue in which they are organised into perimicrovillar membranes (PMMs). 3H-palmitic acid added at the luminal side of isolated midguts of R. prolixus females was readily absorbed and was used to synthesise phospholipids (80%) and NL (20%). The highest incorporation of 3H-palmitic acid was on the first day after a blood meal. The amounts of diacylglycerol (DG) and triacylglycerol synthesised by the tissue decreased in the presence of Lp in the incubation medium. The metabolic fates of 3H-lipids synthesised by the posterior midgut were followed and it was observed that DG was the major lipid released to Lp particles. However, the majority of phospholipids were not transferred to Lp, but remained in the tissue. The phospholipids that were synthesised and accumulated in the posterior midgut were found to be associated with Rhodnius luminal contents as structural components of PMMs.

https://doi.org/10.1590/S0074-0276108042013016 2979 downloads

Genetic divergence between genotypes of forage peanut in relation to agronomic and chemical traits
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Menezes, Ana Paula Morais

; Assis, Giselle Mariano Lessa de

; Mataveli, Marcela

; Silva, Hellen Sandra Freires da

; Azevedo, José Marlo Araújo de

; Mendonça, Márcia Silva de

Revista Brasileira de Zootecnia

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jul 2012, Volume 41 N. 7 Pages 1608 - 1617

Abstract: En | Text: En | PDF: En

The objective of this study was to evaluate the genetic divergence of forage peanut in relation to agronomic and chemical traits in both rainy and dry seasons. This experiment was conducted with genotypes from the Forage Peanut Active Germoplasm Bank located in Embrapa Acre. Eighteen genotypes of forage peanut were used: 12 genotypes of A. pintoi, four genotypes of the A. repens species and two interspecific hybrids of A. pintoi × A. repens. The design was of randomized blocks with five replicates. All traits were submitted to analyses of variance and later, study of genetic divergence was done through multivariate analysis techniques, in which the Tocher's optimization method and the nearest neighbor method were used. Dissimilarity measure used in cluster analysis was the generalized distance of Mahalanobis. No pattern was found in the cluster based on species used, according to the results. There is genetic variability for all traits except neutral detergent fiber, acid detergent fiber, hemicellulose and lignin in the rainy season and for pests in the dry season. The traits which presented most relative contribution in the study of genetic divergence of forage peanut were flowering, dry matter yield and average height in the rainy season and crude protein and average height in the dry season. The established cluster may help the breeder to choose parents and crossings to be selected in forage peanut breeding programs.

1548 downloads

Predictors of the risk of falls among elderly with chronic atrial fibrillation
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Santos, Angela Cristina Silva dos

; Nobre, Moacyr Roberto Cucê

; Nussbacher, Amit

; Rodrigues, Giselle Helena de Paula

; Gebara, Otavio Celso Eluf

; Serro Azul, João Batista Carvalho

; Wajngarten, Mauricio

Clinics

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2012, Volume 67 N. 4 Pages 305 - 311

Abstract: En | Text: En | PDF: En

OBJECTIVES: Though elderly persons with chronic atrial fibrillation have more comorbidities that could limit indications for the chronic use of anticoagulants, few studies have focused on the risk of falls within this particular group. To evaluate the predictors of the risk of falls among elderly with chronic atrial fibrillation, a cross-sectional, observational study was performed. METHODS: From 295 consecutive patients aged 60 years or older with a history of atrial fibrillation who were enrolled within the last 2 years in the cardiogeriatrics outpatient clinic of the Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 107 took part in this study. Their age was 77.9±6.4 years, and 62 were female. They were divided into two groups: a) no history of falls in the previous year and b) a history of one or more falls in the previous year. Data regarding the history of falls and social, demographic, anthropometric, and clinical information were collected. Multidimensional assessment instruments and questionnaires were applied. RESULTS: At least one fall was reported in 55 patients (51.4%). Among them, 27 (49.1%) presented recurrent falls, with body lesions in 90.4% and fractures in 9.1% of the cases. Multivariate logistic regression showed that selfreported difficulty maintaining balance, use of amiodarone, and diabetes were independent variables associated with the risk of falls, with a sensitivity of 92.9% and a specificity of 44.9%. CONCLUSION: In a group of elderly patients with chronic atrial fibrillation who were relatively independent and able to attend an outpatient clinic, the occurrence of falls with recurrence and clinical consequences was high. Difficulty maintaining balance, the use of amiodarone and a diagnosis of diabetes mellitus were independent predictors of the risk for falls. Thus, simple clinical data predicted falls better than objective functional tests.

https://doi.org/10.6061/clinics/2012(04)02 2862 downloads

Volatile and non-volatile compounds and antimicrobial activity of Mansoa difficilis (Cham.) Bureau & K. Schum: (Bignoniaceae)
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Guilhon, Giselle Maria Skelding Pinheiro

; Silva, Elisângela Sarmento da

; Santos, Lourivaldo da Silva

; Zoghbi, Maria das Graças Bichara

; Araújo, Isabella Santos

; Uetanabaro, Ana Paula Trovatti

Química Nova

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2012, Volume 35 N. 11 Pages 2249 - 2253

Abstract: En | Text: En | PDF: En

Essential oil from the leaves of Mansoa difficilis was analyzed by GC/MS. Oct-1-en-3-ol (49.65%) was the major compound, but diallyl di- and trisulfide were also present (0.85 and 0.37%, respectively), justifying the garlic-like odor of the crushed leaves. The hexane and methanol extracts of the leaves and stems afforded as main constituents a mixture of linear hydrocarbons, spinasterol, stigmasterol, ursolic and oleanolic acids, two apigenin derivatives and verbascoside. The hexane and methanol extracts of leaves were tested for antimicrobial activity against ten microorganisms. The hexane extract was active against both Psedomonas aeruginosa and Staphylococcus aureus.

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