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ABSTRACT: This research evaluated different rice genotypes regarding physicochemical and instrumental parameters of grain quality and associated the data with sensory analysis to support the creation of rules for classification of the culinary quality of rice (texture), based on isolated or combined parameters. The combination of amylose content and gelatinization temperature was able to predict the rice quality. According to the sensorial panel, the instrumental stickiness was able to segregate rice with very low amylose content or waxy to the other ones. Regarding pasting properties, rice that presented high final viscosity (310-480 RVU), setback (165-245 RVU), and pasting temperature (78 - 88 °C), and low values for breakdown (15-120 RVU), associated with a high stickiness (>-5N) was desirable by the Brazilian consumers. The classification rules created through the relationship between the physicochemical parameters and the texture profile evaluated by the sensory panel will help to verify the culinary profile of the rice samples (through free software), which makes it easier to predict the probability of rice meeting the desired quality standards.

RESUMO: Este trabalho avaliou diferentes genótipos de arroz quanto a parâmetros físico-químicos e instrumentais de qualidade do grão e associou os dados à análise sensorial para subsidiar a criação de regras de classificação da qualidade culinária do arroz (textura), com base em parâmetros isolados ou combinados. A combinação do teor de amilose e temperatura de gelatinização foi capaz de predizer a qualidade do arroz. De acordo com o painel sensorial, a pegajosidade instrumental foi capaz de segregar arroz com baixo teor de amilose ou ceroso dos demais. Em relação às propriedades de pasta, o arroz que apresentou alta viscosidade final (310-480RVU), retrogradação (165-245RVU) e temperatura de pasta (78-88 °C) e baixos valores de quebra pasta (15-120RVU), associados a uma alta pegajosidade (> -5N) será desejável pelos consumidores brasileiros. As regras de classificação criadas por meio da relação entre os parâmetros físico-químicos e o perfil de textura avaliado pelo painel sensorial ajudarão a verificar o perfil culinário das amostras de arroz (por meio de um software livre), o que torna mais fácil prever a probabilidade de o arroz atender aos padrões de qualidade desejados.

https://doi.org/10.1590/0103-8478cr20230327

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Occurrence of avian reovirus and picobirnavirus in wild birds from an environmental protection area in the Brazilian Amazon
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PEREIRA, Diego

; SOUTO, Lizandra Caroline dos Santos

; GUERRA, Sylvia de Fátima dos Santos

; PENHA-JÚNIOR, Edvaldo Tavares da

; LOBO, Patrícia dos Santos

; SOARES, Luana da Silva

; PINHEIRO, Helder Henrique Costa

; CHAGAS, Elaine Hellen Nunes

; GUIMARÃES, Ricardo José de Paula Souza e

; RAMOS, Bruna Alves

; CHAGAS, Liliane Leal das

; FREITAS, Maria Nazaré Oliveira

; FURTADO, Erilene Cristina da Silva

; RODRIGUES, Jéssica Cecília Pinheiro

; CASSEB, Alexandre do Rosário

; MARTINS, Lívia Caricio

; MASCARENHAS, Joana D’Arc Pereira

Acta Amazonica

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2024, Volume 54 N. 1 elocation e54hs23012

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Wild birds have great prominence in the transmission of diseases to humans, mainly due to their ease of access to human populations, raising concerns about the potential impact of that proximity on public health. The present study reports ARV and PBV occurrence in wild birds from an environmental protection area in the Amazon biome, in Pará state, Brazil. We obtained 155 fecal specimens from 47 species of wild birds for RNA extraction, ARV and PBV detection utilizing molecular methods, nucleotide sequencing, and phylogenetic analysis. ARV prevalence was 0.6% (1/155), being positive in an individual of Myrmotherula longipennis, and PBV prevalence was 1.29% (2/155), affecting two individuals of Guira guira. The PBV strains were assigned to genogroup I based on phylogenetic analysis, and they shared a strong phylogenetic link with strains isolated from different geographic locations. The ARV strain was more closely related to strains that had previously circulated in the same region. The presence of ARV and PBV in this habitat suggests that infection cycles of these agents occur naturally in the wild ecosystem, potentially triggering transmission events between bird species and humans. This is the first study on ARV detection in wild birds in Brazil and the first report on the occurrence of PBV in wild Guira guira. Additional studies are required to determine the epidemiology, origin, evolution, and emergence of new potentially pathogenic viruses in the Amazon.

RESUMO As aves silvestres têm grande destaque na transmissão de doenças ao homem, principalmente pela facilidade de acesso à população humana, levantando preocupações sobre o potencial impacto dessa proximidade no contexto da saúde pública. O presente estudo relata a ocorrência de ARV e PBV em aves silvestres de uma área de proteção ambiental no bioma Amazônico. Obtivemos 155 espécimes fecais de 47 espécies de aves silvestres, que foram submetidos a extração de RNA, detecção de ARV e PBV por técnicas moleculares, sequenciamento nucleotídico e análise filogenética. A prevalência de infecção por ARV foi 0,6% (1/155), sendo positivo em um indivíduo de Myrmotherula longipennis, e a prevalência de PBV foi 1,29% (2/155), afetando dois insdivíduos de Guira guira. A análise filogenética agrupou as cepas de PBV no genogrupo I, mostrando intensa relação filogenética com cepas isoladas de outras regiões geográficas. A cepa de ARV esteve mais relacionada filogeneticamente a cepas previamente circulantes na mesma região. Este é o primeiro estudo sobre detecção de ARV em aves silvestres no Brasil e o primeiro relato sobre a ocorrência de PBV em Guira guira. A circulação de ARV e PBV nesse ambiente demonstra que os ciclos desses agentes estão ocorrendo de forma natural no ecossistema silvestre, o que pode desencadear possíveis eventos de transmissão entre as espécies aviárias e humanos. Estudos adicionais são necessários para determinar a epidemiologia, origem, evolução e surgimento de novos vírus potencialmente patogênicos na Amazônia.

https://doi.org/10.1590/1809-4392202300120

Biogran Grafting in Rat Tibia Defects - A Model of High Bone Metabolism Site
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Ferreira, Luiza de Almeida Queiroz

; Lehman, Luiz Felipe Cardoso

; Diniz, Marina Gonçalves

; Ferreira, Anderson José

; Silva, Rosangela Maria Ferreira da Costa e

; Silva, Tarcília Aparecida

; Mesquita, Ricardo Alves

; Oliveira, Rafaela Férrer de

; Noronha, Mariana Saturnino

; Leão, Daniel Marques

; Andrade, Ângela Leão

; Domingues, Rosana Zacarias

; Diniz, Ivana Márcia Alves

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230003

Abstract: En | Text: En | PDF: En

Abstract We investigated the Biogran on bone repair and metabolism at several time-intervals upon grafting into rat tibia artificial defects. The biomaterial was thoroughly characterized in vitro, and its dissolution behavior upon immersion was assessed in simulated body fluid (SBF) solution for 1, 3, 7, 14, and 30 days. Biogran was also assessed by in vitro hydroxyapatite formation in SBF solution, which is a marker for bioactive behavior. In vivo, distal and proximal bone defects were performed in the Wistar rat's right tibia and filled according to the experimental groups: I) negative control, no filling; II) positive control, 10 mg of autogenous bone; and III) 10 mg of Biogran. Animals were euthanized at 1, 2, 3, 4, 7, and 10 weeks. Bone neoformation was analyzed using histomorphometry (proximal defect), and local levels of bone morphogenetic protein 2 (BMP-2) were measured using the ELISA assay (distal defect). In vitro, the Biogran sample showed a fast dissolution rate within the first 7 days, parallel to the formation of the hydroxyapatite layer. In vivo, the sample was progressively resorbed at a higher rate within the first month until it became almost absent at week 10th. The sample presented similar or higher bone neoformation concerning the autogenous bone. BMP-2 levels were sustained in the Biogran group (around 200 pg/mg) and detected until the last experimental time with a significant difference compared with the controls. Results suggest Biogran is a candidate for hard tissue engineering even in highly active bone remodeling sites.

https://doi.org/10.1590/1678-4324-2024230003

Individual and contextual factors associated with the survival of patients with severe acute respiratory syndrome by COVID-19 in Brazil
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Martins Neto, Carlos

; Silva, Fábio Nogueira da

; Dias Júnior, José de Jesus

; Branco, Maria dos Remédios Freitas Carvalho

; Santos, Alcione Miranda dos

; Oliveira, Bruno Luciano Carneiro Alves de

Revista Brasileira de Epidemiologia

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2024, Volume 27 elocation e240019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Analisar a influência dos fatores individuais e contextuais do hospital e do município de assistência sobre a sobrevida de pacientes com Síndrome Respiratória Aguda Grave por COVID-19. Métodos: Estudo de coorte hospitalar com dados de 159.948 adultos e idosos com Síndrome Respiratória Aguda Grave por COVID-19 internados de 01 de janeiro a 31 de dezembro de 2022 e notificados no Sistema de Informação de Vigilância Epidemiológica da Influenza. As variáveis contextuais foram relacionadas à estrutura, aos profissionais e equipamentos dos estabelecimentos hospitalares e indicadores socioeconômicos e de saúde dos municípios. O desfecho foi a sobrevida hospitalar em até 90 dias. Árvore de sobrevida e curvas de Kaplan-Meier foram utilizados para analisar a sobrevida. Resultados: A letalidade hospitalar foi de 30,4%. Idosos submetidos à ventilação mecânica invasiva e internados em cidades com baixo percentual de arrecadação de impostos apresentaram menor sobrevida quando comparados aos demais grupos identificados na árvore de sobrevida (p<0,001). Conclusão: O estudo indicou a interação de fatores contextuais com os individuais, e evidencia que características hospitalares e dos municípios aumentam o risco de óbito, destacando a atenção à organização, ao funcionamento e desempenho da rede hospitalar.

ABSTRACT Objective: To analyze the influence of individual and contextual factors of the hospital and the municipality of care on the survival of patients with Severe Acute Respiratory Syndrome due to COVID-19. Methods: Hospital cohort study with data from 159,948 adults and elderly with Severe Acute Respiratory Syndrome due to COVID-19 hospitalized from January 1 to December 31, 2022 and reported in the Influenza Epidemiological Surveillance Information System. The contextual variables were related to the structure, professionals and equipment of the hospital establishments and socioeconomic and health indicators of the municipalities. The outcome was hospital survival up to 90 days. Survival tree and Kaplan-Meier curves were used for survival analysis. Results: Hospital lethality was 30.4%. Elderly patients who underwent invasive mechanical ventilation and were hospitalized in cities with low tax collection rates had lower survival rates compared to other groups identified in the survival tree (p<0.001). Conclusion: The study indicated the interaction of contextual factors with the individual ones, and it shows that hospital and municipal characteristics increase the risk of death, highlighting the attention to the organization, operation, and performance of the hospital network.

https://doi.org/10.1590/1980-549720240019

Implementação do Projeto ApiceOn: Desenvolvimento e Prática do Enfermeiro
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Ibiapino, Juliana Louise da Silva

; Chirelli, Mara Quaglio

; Rezende, Kátia Terezinha Alves

; Marin, Maria José Sanches

; Mazzetto, Fernanda Moerbeck Cardoso

; Mielo, Márcio

New Trends in Qualitative Research

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oct 2023, Volume 18 elocation e886

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: O Projeto de Aprimoramento e Inovação no Cuidado e Ensino em Obstetrícia e Neonatologia (ApiceOn), propõe integrar os hospitais de ensino à Rede Cegonha, visa as áreas que se referem ao parto e nascimento, planejamento reprodutivo pós-parto e pós aborto, atenção as mulheres que estão em situação de violência sexual e abortamento e aborto legal, por meio de práticas humanizadas e evidências científicas com a inserção de enfermeiros obstetras e obstetrizes, diretamente relacionadas ao aprendizado dos futuros profissionais. Objetivo: analisar o processo de implementação do projeto ApiceOn em uma instituição hospitalar e como se desenvolveu a inserção do enfermeiro e do enfermeiro obstetra. Métodos: pesquisa de abordagem qualitativa, realizada por meio de entrevitas semi-estruturadas com 15 enfermeiros e tratamento dos dados pela Análise Temática de Conteúdo. Identificou-se como tema o conhecimento e desafios do Projeto ApiceOn: do significado, da implementação, do desenvolvimento e da prática do enfermeiro. Resultados: considera-se que as entrevistadas possuem conhecimento incipiente sobre o projeto, sua implementação e desenvolvimento não há inserção dos enfermeiros e enfermeiros obstetras frente ao projeto. O processo de implantação e implementação do Projeto ApiceOn requer a constituição de cogestão, visto que necessita da construção de novas práticas ancoradas no modelo de vigilância à saúde, superando o modelo biomédico, para tanto a lógica de formação dos profissionais está pautada na educação permanente. Conclusão: há a necessidade de mudança do paradigma de cuidado em saúde e, consequentemente, do processo de trabalho com as gestantes/parturientes/famílias, por meio da implementação e formação para o desenvolvimento do projeto ApiceOn, utilizando protocolos para atuação dos profissionais e organização estrutural.

Abstract Introduction: The Project for Improvement and Innovation in Care and Teaching in Obstetrics and Neonatology (ApiceOn) proposes to integrate teaching hospitals to Rede Cegonha, targets areas related to labor and birth, postpartum and post-abortion reproductive planning, care for women who are in a situation of sexual violence and abortion and legal abortion, through humanized practices and scientific evidence with the insertion of obstetric nurses and midwives, directly related to the learning of future professionals. Goals: analyze the ApiceOn project implementation process in a hospital institution and how the insertion of the nurse and the midwife. Methods: qualitative approach research, with 15 nurses through semi-structured interviews and data processing by Analysis thematic content. The knowledge and challenges of the ApiceOn Project were identified as a theme: the meaning, implementation, development and practice of nursing. Results: it is considered that the interviewees have incipient knowledge about the project, its implementation and development and there is no insertion of nurses and midwives in front of the project. The implementation process of the ApiceOn Project requires the constitution of co-management, since it requires the construction of new practices anchored in the health surveillance model, surpassing the biomedical model, therefore, the training logic of professionals is based on permanent education. Conclusions: there is a need to change the paradigm of health care and, consequently, the work process with pregnant women/pregnant women/families, through the implementation and training for the development of the ApiceOn project, using protocols for the performance of professionals and structural organization.

https://doi.org/10.36367/ntqr.18.2023.e886

Atenção Psicosscocial à População em Situação de Rua frente ao uso de Álcool e outras Drogas: Percepção dos Profissionais Envolvidos
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Souza, Aline Pereira

; Vernasque, Juliana Ribeiro da Silva

; Rodrigues, Paula Sales

; Marin, Maria José Sanches

; Rezende, Kátia Terezinha Alves

New Trends in Qualitative Research

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oct 2023, Volume 18 elocation e870

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A população em situação de rua cresce constantemente, sendo composta por uma grande diversidade de pessoas que estão diariamente expostas às diversas formas de violência, são privadas de direitos fundamentais, não possuem privacidade, têm condições precárias de sono, alimentação e higiene, a maioria faz uso abusivo de álcool e outras drogas. Objetivo: Interpretar como é desenvolvido o cuidado ofertado à população em situação de rua frente ao uso abusivo de álcool e outras drogas. Método: estudo qualitativo, realizado no período de outubro de 2021 a fevereiro de 2022, a partir de 20 entrevistas com profissionais de diferentes serviços da rede de atenção à saúde e de assistência e desenvolvimento social de um interior paulista, por meio da análise temática, utilizando-se da ferramenta NVivo. Resultados: foram identificados os temas: a situação de viver na rua favorece o uso de álcool e outras drogas; incipiente efetivação da Rede de Atenção Psicossocial (RAPS); incipiente efetivação da Política de Redução de Danos e Influência do terceiro setor no cuidado à PSR. Considerações Finais: Evidenciam-se limites para a promoção do cuidado na perspectiva da atenção psicossocial, sendo que para avançar é necessário dar voz e considerar as especificidades da PSR, compreender suas concepções do processo de saúde-doença e suas trajetórias.

Abstract The Homeless people is constantly growing, being made up of a wide range of people who are daily exposed to different forms of violence, are deprived of fundamental rights, lack privacy, have precarious conditions of sleep, food and hygiene. Objective: To understand/interpret how the care offered to the homeless population is developed in relation to the abusive use of alcohol and other drugs. Method: qualitative study, carried out from October 2021 to February 2022, based on 20 interviews with professionals from different services in the health care and assistance and social development network in an interior of São Paulo, through thematic analysis, using the NVivo tool. Results: the themes were identified: the situation of living on the street favors the use of alcohol and other drugs; care proposals centered on abstinence; hospitalization and medicalization weaken the continuity of care; incipient implementation of the Policy of Harm Reduction and Influence of the third sector in the care of PSR. Conclusions: Limits are evident for the promotion of care from the perspective of psychosocial care, and to advance it is necessary to give voice and consider the specificities of HP, understand its conceptions of the health-disease process and its trajectories.

https://doi.org/10.36367/ntqr.18.2023.e870

[SciELO Preprints] - ESCAZÚ AGREEMENT AND ENVIRONMENTAL DEMOCRACY IN THE GOVERNANCE OF THE WATER OF THE MAMORÉ RIVER VERSUS ENERGY EXPANSION
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Silva, Jose Irivaldo Alves Oliveira Nascimento, Leonardo Leite Farias, Talden

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Publication date: 2023-09-23

Abstract: En Pt

This proposal brings the perspective of popular participation rights in decisions on the use of the waters of the Mamoré River, aiming at its governance and water security in the face of the social and environmental risks of the binational hydroelectric project, between Brazil and Bolivia, under study. The aim is to: 1) Verify the right to use international rivers and certain decisions on conflicts over the use of transboundary waters; 2) Evaluate environmental democracy in water governance in Pan-Amazonian rivers; and 3) Analyze how the Escazú Agreement can contribute to guaranteeing environmental democracy in decisions on the use of waters from the international Mamoré River in relation to the binational hydroelectric development project planned in the Madeira Complex. To achieve reconciliation between development and the environment in the Pan-Amazon, it is necessary to limit the global forces of exploitation of existing environmental assets, including the use of water resources to generate electrical energy.

A presente proposta traz a perspectiva dos direitos de participação popular nas decisões de uso das águas do rio Mamoré, visando sua governança e segurança hídrica frente aos riscos sociais e ambientais do projeto da hidrelétrica binacional, entre Brasil e Bolívia, em estudo. Pretende-se: 1) Verificar o direito dos usos dos rios internacionais e certas decisões sobre conflitos de uso de águas transfronteiriças; 2) Avaliar a democracia ambiental na governança de águas de rios da Pan-Amazônia; e 3) Analisar como o Acordo de Escazú pode contribuir para garantir a democracia ambiental nas decisões de uso das águas do rio internacional Mamoré frente ao projeto de desenvolvimento de hidrelétrica binacional planejado no Complexo do Madeira. Para ser alcançada a conciliação entre desenvolvimento e meio ambiente na Pan-Amazônia é necessário serem limitadas as forças globais de exploração dos bens ambientais existentes, entre os quais o uso dos recursos hídricos para geração de energia elétrica.

https://doi.org/10.1590/SciELOPreprints.6933

Comparação dos casos de beribéri entre indígenas e não indígenas, Brasil, 2013 a 2018
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Assunção, Anne Karine Martins

; Branco, Maria dos Remédios Freitas Carvalho

; Santos, Thiago de Sousa

; Costa, Silmery da Silva Brito

; Dias Júnior, José de Jesus

; Frota, Maria Tereza Borges Araújo

; Oliveira, Bruno Luciano Carneiro Alves de

; Santos, Alcione Miranda dos

Ciência & Saúde Coletiva

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jul 2023, Volume 28 N. 7 Pages 1993 - 2002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O beribéri é a manifestação clínica da deficiência grave e prolongada de tiamina (vitamina B1). Doença negligenciada que acomete a população de baixa renda, em situação de insegurança alimentar e nutricional. O objetivo do estudo foi comparar casos de beribéri em indígenas com casos em não indígenas no Brasil. Trata-se de estudo transversal de casos notificados de beribéri no período de 2013 a 2018, no formulário do SUS (FormSUS) do Ministério da Saúde. Foram comparados os casos em indígenas e em não indígenas pelo teste qui-quadrado ou teste exato de Fisher com nível de significância de p < 0,05. No período estudado foram notificados no país 414 casos de beribéri, sendo 210 (50,7%) indígenas. Referiram consumo de bebidas alcoólicas 58,1% dos indígenas e 71,6% dos não-indígenas (p = 0,004); adicionalmente, 71,0% dos indígenas consumiam caxiri (bebida alcoólica tradicional fermentada). Relataram fazer esforço físico diário 76,1% dos indígenas e 40,2% dos não-indígenas (p <0 ,001). Conclui-se que o beribéri no país acomete mais indígenas e está relacionado ao consumo de álcool e ao esforço físico.

Abstract Beriberi is the clinical manifestation of severe and prolonged thiamine (vitamin B1) deficiency. It is a neglected disease that affects low-income populations facing food and nutrition insecurity. The aim of this study was to compare cases of beriberi among indigenous and non-indigenous people in Brazil. We conducted a cross-sectional study using data on cases of beriberi during the period July 2013-September 2018 derived from beriberi notification forms available on the FormSUS platform. Cases in indigenous and non-indigenous patients were compared using the chi-squared test or Fisher’s exact test, adopting a significance level of 0.05. A total of 414 cases of beriberi were reported in the country during the study period, 210 of which (50.7%) were among indigenous people. Alcohol consumption was reported by 58.1% of the indigenous patients and 71.6% of the non-indigenous patients (p = 0.004); 71.0% of the indigenous patients reported that they consumed caxiri, a traditional alcoholic drink. Daily physical exertion was reported by 76.1% of the indigenous patients and 40.2% of the non-indigenous patients (p < 0.001). It is concluded that beriberi disproportionately affects indigenous people and is associated with alcohol consumption and physical exertion.

https://doi.org/10.1590/1413-81232023287.16422022

10.

Comparison of strip meniscometry and Schirmer tear test results and tear film breakup time between healthy dogs and dogs with dry eye disease
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Nascimento, Felipe Franco

; Passareli, João Victor Goulart Consoni

; Zulim, Luís Felipe da Costa

; Silva, Danielle Alves

; Giuffrida, Rogerio

; Estanho, Giovana José Garcia

; Villa, Mayra Claudino

; Andrade, Silvia Franco

Arquivos Brasileiros de Oftalmologia

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jul 2023, Volume 86 N. 4 Pages 314 - 321

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Purpose: To compare strip meniscometry and Schirmer tear test 1 results and tear film breakup time between dogs with normal eyes and dogs diagnosed with keratoconjunctivitis sicca. Methods: One-hundred fifty-six eyes of 78 dogs, 88 normal eyes, and 68 eyes diagnosed with keratoconjunctivitis sicca were included in the study. The tests were performed in the following sequence: Schirmer tear test 1 was used to allocate the dogs to the normal or keratoconjunctivitis sicca group, followed by the strip meniscometry test and tear film breakup time measurement. Results: The results (mean ± standard deviation) of the tests in the normal group were as follows: Schirmer tear test 1, 22.75 ± 3.88 mm/min; strip meniscometry test, 10.01 ± 2.35 mm/5 sec; and tear film breakup time, 25.82 ± 5.47 sec. In the keratoconjunctivitis sicca group, the results were as follows: Schirmer tear test 1, 6.10 ± 4.44 mm/min; strip meniscometry test, 3.03 ± 2.62 mm/5 sec; and tear film breakup time, 10.78 ± 4.23 sec. The Spearman correlation coefficient in the keratoconjunctivitis sicca group was very high, with a significant difference between the strip meniscometry test and Schirmer tear test 1 (r=0.848, p<0.001), and moderate and significant between the strip meniscometry test and tear film breakup time (r=0.773, p<0.001). The cutoff for the strip meniscometry test for keratoconjunctivitis sicca was 7.0 mm/5 sec. Keratoconjunctivitis sicca was suspected when the values were <10 mm/5 sec. Conclusions: This study provided strip meniscometry test values from dogs with normal eyes and eyes with keratoconjunctivitis sicca, with high sensitivity and specificity compared with those of the Schirmer tear test 1. In the future, the strip meniscometry test may be another important quantitative test and could complement the gold standard Schirmer tear test for the diagnosis of keratoconjunctivitis sicca in dogs, an excellent animal model for the study of the disease.

RESUMO Objetivo: Comparar o teste de meniscometria em tira com o teste lacrimal de Schirmer 1 e o tempo de ruptura do filme lacrimal, em cães com olhos normais e cães com diagnóstico de ceratoconjuntivite seca. Métodos: Cento e cinquenta e seis olhos de 78 cães, 88 olhos normais e 68 olhos com diagnóstico de ceratoconjuntivite seca. Os testes foram realizados na seguinte sequência: o teste lacrimal de Schirmer 1 foi utilizado para alocar os cães no grupo normal ou no grupo ceratoconjuntivite seca, seguido pelo teste de meniscometria em tira e tempo de ruptura do filme lacrimal. Resultados: As médias e desvios-padrão para os olhos normais foram: teste lacrimal de Schirmer 1 = 22,75 ± 3,88 mm / min; teste de meniscometria em tira = 10,01 ± 2,35 mm / 5 seg; tempo de ruptura do filme lacrimal = 25,82 ± 5,47 seg; e para os olhos do grupo ceratoconjuntivite seca foram: teste lacrimal de Schirmer 1 = 6,10 ± 4,44 mm / min; teste de meniscometria em tira = 3,03 ± 2,62 mm / 5 seg; tempo de ruptura do filme lacrimal = 10,78 ± 4,23 seg. O teste de correlação de Spearman no grupo ceratoconjuntivite seca foi muito alto, com diferença significativa entre teste de meniscometria em tira e teste lacrimal de Schirmer 1 (r=0,848, p<0,001), moderada e significativa entre teste de meniscometria em tira e tempo de ruptura do filme lacrimal (r=0,773, p<0,001). O cut-off para teste de meniscometria em tira para ceratoconjuntivite seca foi identificado em 7,0 mm / 5 seg, valores abaixo de 10 mm / 5 seg podem ser considerados suspeitos para KCS. Conclusões: Este estudo forneceu valores de teste de meniscometria em tira em olhos normais e com ceratoconjuntivite seca em cães, revelando alta sensibilidade e especificidade em comparação com o teste lacrimal de Schirmer 1. No futuro, o teste de meniscometria em tira pode ser outro teste quantitativo importante e pode complementar o teste lacrimal de Schirmer padrão ouro para o diagnóstico de ceratoconjuntivite seca em cães, um excelente modelo animal para o estudo de ceratoconjuntivite seca.

https://doi.org/10.5935/0004-2749.20230057

11.

Comparação dos casos de beribéri entre indígenas e não indígenas, Brasil, 2013 a 2018
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Assunção, Anne Karine Martins

; Branco, Maria dos Remédios Freitas Carvalho

; Santos, Thiago de Sousa

; Costa, Silmery da Silva Brito

; Dias Júnior, José de Jesus

; Frota, Maria Tereza Borges Araújo

; Oliveira, Bruno Luciano Carneiro Alves de

; Santos, Alcione Miranda dos

Ciência & Saúde Coletiva

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jul 2023, Volume 28 N. 7 Pages 1993 - 2002

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-81232023287.16422022

12.

Prejudice impairing quality of life in sickle cell disease patients in a developing country: faces of suffering
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Rodrigues, Camila Freitas de Andrade

; Rodrigues, Thiago Alves

; Oliveira, Eduardo José Silva Gomes de

; Garcia, João Batista Santos

; Cartágenes, Maria do Socorro de Sousa

Hematology, Transfusion and Cell Therapy

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jul 2023, Volume 45 Suppl. 2 Pages S3 - S10

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. Methods: This is a cross-sectional study conducted between March 2019 and February 2020, with patients diagnosed with SCD. Patients were questioned about the perception of prejudice in any kind of situation, choosing between “Yes” or “No”, not differentiating situations related to prejudice. To assess the QoL and impact of the disease, the volunteers answered a version of the SF-36 questionnaire translated and validated into Brazilian Portuguese. Results: In this study, 113 patients with SCD were followed up, 92% were classified as HbSS and the rest, divided between HbSC and HbS-β-0. Regarding the SF-36, the worst scores were in the summary of the physical components (mean 48.19 ± 21.51) and the physical aspect had the lowest mean (30.75 ± €42.65). When questioned if they had already perceived any kind of prejudice, including the SCD, 32.74% answered “Yes”. For this comparison, there was a significant difference in the summary of the physical and mental components, with worse QoL for those who had already suffered prejudice. Conclusion: Patients diagnosed with SCD who reported perception of prejudice had statistically significant worse QoL, revealing the negative impact, that might lead to sadness and social isolation.

https://doi.org/10.1016/j.htct.2021.06.002

13.

Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study
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Ferreira-deLima, Mabelle Alves

; Costa-de Souza, Karla Simone

; Endrigo-Silva-de Andrade, César

; Abbott-Galvão-Ururahy, Marcela

; de Medeiros, Paulo José

; Galvão-Pereira, Maurício

; de Almeida, José Bruno

; Cavalcanti-Maurício-Sena-Evangelista, Karine

; Augusto-de Rezende, Adriana

Nutrición Hospitalaria

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apr 2023, Volume 40 N. 2 Pages 412 - 418

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Introduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies.

Resumen Introducción: los bajos niveles de 25-hidroxivitamina D [25(OH)D] ocurren después del procedimiento de trasplante de riñón (KTx) y pueden estar asociados con un aumento del riesgo de pérdida del injerto. Este estudio longitudinal tuvo como objetivo evaluar el estado de la vitamina D y la asociación con los biomarcadores de función del injerto renal después del KTx. Métodos: este estudio longitudinal incluyó a 42 pacientes que fueron evaluados al inicio del estudio, y 3 y 6 meses después del KTx. Se evaluaron los parámetros biodemográficos, clínicos y bioquímicos, como 25(OH)D y hormona paratiroidea (PTH), y los biomarcadores de función del injerto renal, como creatinina, tasa de filtración glomerular estimada (eGFR) y relación albúmina/creatinina (ACR). También se evaluó la exposición al sol. Los pacientes se clasificaron según sus niveles de 25(OH)D. Resultados: al inicio del estudio se encontraron niveles de 25(OH)D < 30 ng/ml en el 43 % de los pacientes, mientras que el 38 % de estos pacientes no lograron mejorar sus niveles de 25(OH)D a los 6 meses después del KTx. También se produjeron niveles bajos de 25(OH)D independientemente de la exposición al sol. Asimismo, el 44 % de los pacientes desarrollaron albuminuria a los 6 meses. Se observó un aumento de la ACR en los pacientes con niveles de 25(OH)D < 30 ng/mL (p = 0,002) en comparación con los pacientes con 25(OH)D > 30 ng/mL. Además, los niveles de 25(OH)D se correlacionaron negativamente con la ACR a los 6 meses después del KTx (r = -0,444; p = 0,003). Doce (28,6 %) pacientes con niveles de 25(OH)D < 30 ng/ml no mostraron recuperación de la TFGe hasta 6 meses después del KTx. Conclusión: se observaron niveles bajos de vitamina D y un aumento de la albuminuria a los 6 meses después del KTx, incluso en una región con alta exposición solar. La asociación entre el estado de la vitamina D y los biomarcadores de función del injerto renal después del KTx debe explorarse en estudios adicionales.

https://doi.org/10.20960/nh.04024

14.

Dynamic cystoscopy to optimize preoperative assessment of bladder endometriosis
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Silva Filho, Fernando Salles da

; Favorito, Luciano Alves

; Crispi, Claúdio Peixoto

; Fonseca, Marlon de Freitas

; Resende Júnior, José Anacleto de

International braz j urol

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apr 2023, Volume 49 N. 2 Pages 202 - 210

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose Bladder endometriosis (BE) accounts for 84% of cases of urinary tract involvement. The use of cystoscopy for preoperative evaluation is limited. The aim of this study was to evaluate the accuracy of preoperative dynamic cystoscopy (DC) in patients undergoing surgery for deep endometriosis and to describe the main findings and their impact on surgical planning. Materials and Methods This cross-sectional observational study was conducted from January 2011 to March 2022. DC findings were divided into two groups according to the depth of involvement. To estimate sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), laparoscopic findings of bladder involvement and histopathological report were used as the gold standard. Results We included 157 patients in this study. 41 had abnormalities in DC. Of these, 39 had abnormalities that were confirmed intraoperatively. The sensitivity and specificity of the test were 58.21% and 97.78%, respectively. PPV was 95.12%, and NPV was 75.86%. The presence of any lesions in the DC had a diagnostic odds ratio (OR) of 61.28 for BE. Patients with BE type 2 had a higher rate of partial cystectomy than those with BE type 1 lesions (OR 9.72 CI 95% 1.9-49.1) Conclusion DC appears to be a highly specific test with lower sensitivity. DC abnormalities are associated with a higher ratio of bladder surgery for the treatment of deep endometriosis, and BE type 2 seems to be associated with a greater ratio (9.72) of partial cystectomy.

https://doi.org/10.1590/s1677-5538.ibju.2022.0594

15.

Cannabis products: medical use products
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Fernandes, César Eduardo

; Dolci, José Eduardo Lutaif

; Navarro, Leonardo Sobral

; Allevato, Marcelo

; Constantino, Clóvis Francisco

; Pereira, Rodrigo Pastor Alves

; Rieder, Carlos Roberto de Mello

; Torino, Flávia

; Bernardo, Wanderley Marques

; Silva, Antônio Geraldo da

Revista da Associação Médica Brasileira

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mar 2023, Volume 69 N. 3 Pages 358 - 364

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2023d693

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