Studying indigenous languages is, in a way, supporting the current social and political causes of native peoples. The article aims to discuss the concept of usage according to the linguistic thought of José de Anchieta (1534-1597), based on the text Arte de gramática da língua mais usado na costa do Brasil (Anchieta, 1990 [1595]). The term usage (uso) is documented at va-rious points in his grammar, which describes the Tupinambá language used in the intercultural catechesis activities of the 16th-century Portuguese America. The theoretical and methodolo-gical foundation employed in the research is Historiography of Linguistics, following the mo-del of Konrad Koerner (2014) and Pierre Swiggers (2019; Batista, 2019), aiming to investigate Anchieta's linguistic thought. The investigation's outcome reveals the relationship between the missionary's use of the term usage and theological-philosophical and grammatical conceptions that influenced his thinking. This demonstrates the prevalent linguistic thought in the missionary policy of 16th-century Portuguese America, within which his grammatical work is situated.

Estudar as línguas indígenas é, de certa forma, apoiar as causas sociais e políticas atuais dos povos originários. O artigo tem como objetivo debater o conceito de uso segundo o pensamento linguístico de José de Anchieta (1534-1597), a partir do texto Arte de gramática da língua mais usado na costa do Brasil (Anchieta, 1990 [1595]). O termo uso é registrado em diversos momentos em sua gramática que descreve a língua tupinambá empregada nas atividades de catequese intercultural da América portuguesa quinhentista. A fundamentação teórico-metodológica a ser empregada na pesquisa é a Historiografia da Linguística, conforme o modelo de Konrad Koerner (2014) e Pierre Swiggers (2019; Batista, 2019), em que temos como escopo a investigação do pensamento linguístico (linguistic thought) de Anchieta. Como resultado da investigação, encontramos a relação do emprego do termo uso na obra do missionário com concepções teológico-filosóficas e gramaticais que influíram em seu pensamento, o que denota o pensamento linguístico vigente na política missionária da América portuguesa do século XVI, em que a sua obra gramatical se situa.

The Latin Grammaticography in Brazil is one of the subjects of interest in the discipline of Historiography of Linguistics (HL) within our national context. In our text, we discuss theoretical and methodological aspects regarding the construction of a historiographical narrative on the history of Latin grammar in Brazil, following the "koernian" model developed by Konrad Koerner (2014) and Pierre Swiggers (2013; 2019). As an exemplary model for a (meta)historiographical narrative of the history of Latin grammar in Brazil, we also have the recent publication by Ricardo Cavaliere (UFF/ABL) on the history of grammar in Brazil (CAVALIERE, 2022), which can serve as a model for applying the "koernian" historiography for an analysis of our specific context. The topic of the history of Latin grammar in Brazil was approached in a pioneering way by the Latinist and philologist Ernesto Faria (1906-1962) in two of his main works: Gramática Superior da Língua Latina (FARIA, 1958) and Introdução à Didática do Latim (FARIA, 1959).

A Gramaticografia latina no Brasil é um dos temas de interesse da disciplina de Historiografia da Linguística (HL), em nosso contexto nacional. Em nosso texto, debateremos aspectos teórico-metodológicos, acerca da constituição de uma narrativa historiográfica sobre a história da gramática latina no Brasil, pelo modelo “koerniano”, desenvolvido por Konrad Koerner (2014) e Pierre Swiggers (2013; 2019). Como modelo exemplar, para uma narrativa (meta)historiográfica da história da gramática latina no Brasil, temos também a recente publicação de Ricardo Cavaliere (UFF/ABL), sobre a história da gramática no Brasil (CAVALIERE, 2022), que pode nos servir de modelo à aplicação da historiografia “koerniana”, para uma análise de nosso contexto específico. O tema da história da gramática latina no Brasil foi abordado de forma precursora pelo latinista e filólogo Ernesto Faria (1906-1962), em duas de suas principais obras: a Gramática Superior da Língua Latina (FARIA, 1958) e Introdução à didática do Latim (FARIA, 1959).

ABSTRACT: This study estimated the growth of body, carcass, primal cuts, edible offal, and feathers of Japanese quail reared in two thermal environments, receiving three nutritional plans, from one to 39 days of age. A total of 576 one-day-old female chicks (Coturnix japonica) with an average initial weight of 7.51±0.75g/bird were evaluated in a completely randomized design with a 3 × 2 factorial arrangement (three nutritional plans × two temperatures). The animals were housed in two climatic chambers, at 25 ºC and 35 ºC, using 12 replications with eight birds per experimental unit. Nutritional plans (NP) were as follows: NP1: one diet from 1-21days and another from 22-39 days; NP2: one diet from 1-14 days and another from 15-39 days; and NP3: a single diet from 1-39 days. The growth curves and growth rates of body, carcass, primal cuts, feathers, and edible offal were evaluated using the Gompertz mathematical model. Quail fed NP3 showed higher growth curves and rates for body, carcass, drumstick +thigh, and feather. There was an effect on maturity rate, which was lowest in quail housed at 35 ºC. Among the animals kept at 25 ºC, the group fed NP3 exhibited the highest growth rate and breast weight. The nutritional plan consisting of a single diet offered from 1 to 39 days, formulated based on the tables for Japanese and European quail, is the most suitable for estimating the growth curves (Gompertz model) of Japanese quail housed at 25 ºC or 35 ºC.

RESUMO: Objetivou-se estimar o crescimento corporal, carcaça, cortes nobres, vísceras comestíveis e penas de codornas japonesas criadas em dois ambientes térmicos e alimentadas com três planos nutricionais de um a 39 dias. Foram utilizadas 576 pintainhas (Coturnix japônica), fêmeas, com um dia de idade, com peso médio inicial 7,51 ± 0,75g/ave, distribuídas em delineamento inteiramente casualizado em esquema fatorial 3 × 2 (três planos nutricionais x duas temperaturas), alojadas em duas câmaras climáticas de 25º e 35 ºC, com 12 repetições e oito aves por unidade experimental. Os planos nutricionais foram: plano nutricional um (PN1) - uma dieta de 1-21 dias e uma dieta de 22-39 dias; plano nutricional dois (PN2) - uma dieta de 1-14 dias e uma dieta de 15-39 dias; e plano nutricional três (PN3) - dieta única de 1-39 dias. Foram avaliadas as curvas e taxas de crescimento corporal, carcaça, cortes nobres, penas e vísceras comestíveis, através do modelo matemático de Gompertz. Codornas alimentadas com PN3 apresentaram maiores curvas e taxas de crescimento corporal, de carcaça, coxa + sobrecoxa e penas. Houve efeito para taxa de maturidade, sendo inferior para codornas alojadas em 35 ºC. Nas aves mantidas em 25 ºC, observou-se maior taxa de crescimento e peso de peito nas codornas alimentadas com PN3. O plano nutricional composto por uma única dieta ofertada durante o período de um a 39 dias, formulado com base nas recomendações das tabelas para codornas japonesas e europeias, é o mais indicado para estimar curvas de crescimento no modelo de Gompertz de codornas japonesas alojadas em 25 ºC ou 35 ºC.

Abstract The construction of high-rise buildings has emerged as a constructive trend worldwide, and excessive vibration problems due to wind actions are becoming increasingly frequent. The Brazilian design standard NBR 6123 recommends that the transfer of wind actions used for structural analysis be carried out based on the pressure coefficients along the building facades for static analyses and considers their non-deterministic dynamic behaviour through a stochastic modelling method of the wind velocity field. To present an alternative approach to this methodology, this study aims to investigate the non-deterministic dynamic structural response of a real reinforced concrete building, considering the soil-structure interaction effect, using the pressure coefficients obtained through different methodologies such as numerical simulations using Computational Fluid Dynamics (CFD), international databases, and the recommendations of the Brazilian standard NBR 6123.

Resumo A construção de edifícios altos tem se mostrado uma tendência construtiva ao redor do mundo, e vibrações excessivas oriundas das ações do vento tem se tornado cada vez mais frequentes. A norma brasileira de projeto NBR 6123 recomenda que a transferência das ações de vento utilizadas para análise estrutural seja realizada com base nos coeficientes de pressão ao longo das fachadas do edifício, para análises estáticas, e considera o seu comportamento dinâmico não determinístico através de um método de modelagem estocástica do campo de velocidade do vento. Objetivando apresentar uma abordagem alternativa para esta metodologia, este estudo tem como objetivo investigar a resposta estrutural dinâmica não determinística de um edifício real de concreto armado, considerando o efeito da interação solo-estrutura, utilizando coeficientes de pressão obtidos por intermédio de metodologias distintas, tais como: simulações numéricas utilizando CFD (Computational Fluid Dynamics), bases de dados internacionais, e utilizando as recomendações da norma brasileira NBR 6123.

The present work, which is a segment of an ongoing doctoral research, consists of a brief analysis of the work titled Exposition d’une méthode raisonnée pour apprendre la langue latine (Exposition of a reasoned method for learning the Latin language) (1722), authored by the French grammarian and philosopher César Chesneau Du Marsais (1676-1756). Du Marsais, who authored works such as Méthode raisonnée (1722), Traité des Tropes (1730), Principes de Grammaire (1769), among others, was also a contributor to the Encyclopédie, ou dictionnaire raisonné des sciences, des arts et des métiers (D’ALEMBERT; DIDEROT, 1751-1772), responsible for the grammar articles within the publication. As a result, the philosopher became a highly regarded grammarian in France, also influencing the linguistic thought of grammarians in other countries. One of Du Marsais' major works, which constitutes the focus of the doctoral research, "méthode raisonnée," is a method for learning the Latin language within a secular context, thereby breaking away from Jesuit educational standards. The circulation of this method had positive repercussions due to its organization, structure, methodology, and its 'innovative' characteristic. However, it also faced negative repercussions due to its secular approach to education.

O presente trabalho, que é um recorte da pesquisa de doutorado ainda em fase inicial, consiste em uma breve análise da obra intitulada Exposition d’une méthode raisonnée pour apprendre la langue latine (Exposição de um método racional para aprender a língua latina) (1722), do gramático e filósofo francês César Chesneau Du Marsais (1676-1756). O filósofo que é o autor das obras Méthode raisonnée (1722), Traité des Tropes (1730), Principes de Grammaire (1769) etc., Du Marsais também foi um dos colaboradores da Encyclopédie, ou dictionnaire raisonné des sciences, des arts et des métiers (D’ALEMBERT; DIDEROT,1751-1772), responsável pelos artigos de gramática que integram a obra. Em virtude disso, o filósofo tornou-se um gramático prestigiado na França, influindo também o pensamento linguístico de gramáticos de outros países. Uma das grandes obras de Du Marsais, que é corpus da pesquisa de doutorado, o méthode raisonnée, é um método de aprendizagem da língua latina em um contexto secular, ocasionando a descontinuidade com os padrões educacionais jesuíticos. A circulação do método repercutiu positivamente devido a sua organização, estrutura, metodologia e sua característica “inovadora”, mas também repercutiu de modo negativo em razão de um ensino secular.

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD.

Abstract Background Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care. Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil. Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology (n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 (n = 187). The invitation was also diffused through social media. Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) (n = 211), bipolar disorder (n = 117) and dementia with Lewy bodies (n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively. Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.

Resumo Antecedentes A demência frontotemporal (DFT) é causa frequente de demência pré-senil e representa um desafio em termos de diagnóstico e de manejo clínico. É essencial avaliar as dificuldades existentes na propedêutica e nos cuidados médicos. Objetivo Investigar as práticas médicas e as dificuldades para diagnóstico e manejo da DFT no Brasil. Métodos Elaborou-se um questionário online, composto de 29 questões, divididas em quatro partes, com perguntas sobre infraestrutura existente, práticas clínicas relacionadas à DFT e sugestões para desenvolver a pesquisa nacional na área. O convite para participação foi enviado por e-mail a todos neurologistas afiliados à Academia Brasileira de Neurologia (n = 3658), e aos médicos que participaram da XII Reunião de Pesquisadores de Doença de Alzheimer, em 2019 (n = 187). O convite também foi divulgado através de mídias sociais. Resultados 256 médicos brasileiros responderam o questionário. Os três principais diagnósticos diferenciais de DFT foram doença de Alzheimer (n = 211), transtorno bipolar (n = 117) e demência com corpos de Lewy (n = 92). A maior parte dos respondedores (125/256) apontou a dificuldade em realizar testagem genética como o maior limite no diagnóstico de DFT. 93% e 63% dos respondedores indicaram que a avaliação de cognição social e o uso de biomarcadores liquóricos de doença de Alzheimer são úteis no diagnóstico de DFT, respectivamente. Conclusões Estes resultados devem ser considerados na educação e treinamento médicos, e no desenvolvimento da pesquisa brasileira em DFT.

In the article, we discuss a didactic model for the periodization of the history of linguistic thought in Brazil, based on the theoretical-methodological model of Pierre Swiggers (2012; 2019; BATISTA, 2019; ALTMAN, 2019) and on periodization studies of the history of grammar, by Ricardo Cavaliere (2002; 2012). Our proposal, still in the development and theoretical debate phase (KALTNER, 2019, 2020a, 2020b), is to link the history of linguistic thought in Brazil to institutional history, in which there were three great specific administrative models: the ancient colony, the Empire and the Republic. These changes can also be related to three moments in the development of the history of linguistic thought: a missionary period, a secular period and a scientific period, according to the theoretical model still in development. As a case study, we propose to analyze a periodization related to the Art of Grammar of the most used language on the coast of Brazil (ANCHIETA, 1595), the first work with metalinguistic reflections in the context of Brazil, written between 1554 and 1556.

No artigo, discutimos um modelo didático para a periodização da história do pensamento linguístico no Brasil, pelo modelo teórico-metodológico de Pierre Swiggers (2012; 2019; BATISTA, 2019; ALTMAN, 2019) e pelos estudos de periodização de história da gramática, de Ricardo Cavaliere (2002; 2012). Nossa proposta, ainda em fase de desenvolvimento e de debate teórico (KALTNER, 2019, 2020a, 2020b), é vincular a história do pensamento linguístico no Brasil à história institucional, em que houve três grandes modelos administrativos específicos: a antiga colônia, o Império e a República. Essas mudanças institucionais teriam se relacionado a três momentos também no desenvolvimento da história do pensamento linguístico: um período missionário, um período secular e um período científico, segundo o modelo teórico ainda em desenvolvimento. Como estudo de caso, propomos analisar uma periodização relacionada à Arte de gramática da língua mais usada na costa do Brasil (ANCHIETA, 1595), primeira obra com reflexões metalinguísticas no contexto do Brasil, escrita entre 1554 e 1556.

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

ABSTRACT Toxoplasmosis is an infection of vast worldwide distribution whose etiologic agent is Toxoplasma gondii. This disease can cause problems ranging from mild symptoms to serious conditions, such as encephalitis, miscarriage and blindness. Therefore, it is of utmost importance to perform a diagnosis with reproducible techniques in order to obtain a good prognosis. The aim of this review was to analyze the efficiency of toxoplasmosis diagnostic techniques based on sensitivity and specificity results. Five research platforms in English language were used (Eric, Elsevier, Google Scholar, PubMed and SciELO), which contained data on the diagnosis of toxoplasmosis. The search and selection were performed for studies published prior to June 2021. The search resulted in the inclusion of 13 articles published from 2005 to 2020. The data revealed the use of different samples in the standardization of techniques such as serum, total blood, colostrum and amniotic fluid. The flow cytometry, lateral flow immunoassay and qPCR techniques showed 100% sensitivity, whereas the ELISA, western blotting, qPCR and RE-LAMP techniques achieved 100% specificity. Significantly, the qPCR and LAMP techniques were more accurate when the likelihood ratio was assessed. The meta-analysis identified that ISAGA and western blotting have low sensitivity values and LIASON, ELFA and ELISA, using a silica bioconjugate, also have low specificity values. It was noted that a wide range of methods have high values of sensitivity and specificity. Therefore, the choice of the method will be based on the conditions and its financial viability.

ABSTRACT Cystic fibrosis (CF) is a genetic disease that results in dysfunction of the CF transmembrane conductance regulator (CFTR) protein, which is a chloride and bicarbonate channel expressed in the apical portion of epithelial cells of various organs. Dysfunction of that protein results in diverse clinical manifestations, primarily involving the respiratory and gastrointestinal systems, impairing quality of life and reducing life expectancy. Although CF is still an incurable pathology, the therapeutic and prognostic perspectives are now totally different and much more favorable. The purpose of these guidelines is to define evidence-based recommendations regarding the use of pharmacological agents in the treatment of the pulmonary symptoms of CF in Brazil. Questions in the Patients of interest, Intervention to be studied, Comparison of interventions, and Outcome of interest (PICO) format were employed to address aspects related to the use of modulators of this protein (ivacaftor, lumacaftor+ivacaftor, and tezacaftor+ivacaftor), use of dornase alfa, eradication therapy and chronic suppression of Pseudomonas aeruginosa, and eradication of methicillin-resistant Staphylococcus aureus and Burkholderia cepacia complex. To formulate the PICO questions, a group of Brazilian specialists was assembled and a systematic review was carried out on the themes, with meta-analysis when applicable. The results obtained were analyzed in terms of the strength of the evidence compiled, the recommendations being devised by employing the GRADE approach. We believe that these guidelines represent a major advance to be incorporated into the approach to patients with CF, mainly aiming to favor the management of the disease, and could become an auxiliary tool in the definition of public policies related to CF.

RESUMO A fibrose cística (FC) é uma doença genética que resulta em disfunção da proteína reguladora de condutância transmembrana da FC (CFTR), que é um canal de cloro e bicarbonato expresso na porção apical de células epiteliais de diversos órgãos. A disfunção dessa proteína resulta em manifestações clínicas diversas, envolvendo primariamente os sistemas respiratório e gastrointestinal com redução da qualidade e expectativa de vida. A FC ainda é uma patologia incurável, porém o horizonte terapêutico e prognóstico é hoje totalmente distinto e muito mais favorável. O objetivo destas diretrizes foi definir recomendações brasileiras baseadas em evidências em relação ao emprego de agentes farmacológicos no tratamento pulmonar da FC. As perguntas PICO (acrônimo baseado em perguntas referentes aos Pacientes de interesse, Intervenção a ser estudada, Comparação da intervenção e Outcome [desfecho] de interesse) abordaram aspectos relativos ao uso de moduladores de CFTR (ivacaftor, lumacaftor + ivacaftor e tezacaftor + ivacaftor), uso de dornase alfa, terapia de erradicação e supressão crônica de Pseudomonas aeruginosa, e erradicação de Staphylococcus aureus resistente a meticilina e do complexo Burkholderia cepacia. Para a formulação das perguntas, um grupo de especialistas brasileiros foi reunido e realizou-se uma revisão sistemática sobre os temas, com meta-análise quando aplicável. Os resultados encontrados foram analisados quanto à força das evidências compiladas, sendo concebidas recomendações seguindo a metodologia GRADE. Os autores acreditam que o presente documento represente um importante avanço a ser incorporado na abordagem de pacientes com FC, objetivando principalmente favorecer seu manejo, podendo se tornar uma ferramenta auxiliar na definição de políticas públicas relacionadas à FC.

Abstract Background Use of endolaser for chronic venous disease involves choosing the laser wavelength and optical fiber to use and the quantity of energy to be administered. Efficacy is assessed by the venous occlusion rate and safety is evaluated in terms of side effects. Objectives To determine the incidence of total post-endolaser saphenous vein occlusion at 1-year follow-up. To describe side effects and their incidence and rates of reintervention or supplementary treatment during the postoperative period. Methods A retrospective, observational cohort study with a quantitative approach, enrolling patients with saphenous vein incompetence treated with intravenous 1,470 nm laser ablation. Data were input to an MS Excel 2019 spreadsheet, calculating means and standard deviations with the software’s Power Query supplement. Results 38 patients and 104 venous segments were eligible for the study. 100% were occluded at 30 days and 99.04% were still occluded at 1 year after the procedure. Mean Linear Endovenous Energy Density administered to the internal saphenous vein was 2,040.52 W/cm/s with standard deviation of ± 1,510.06 W/cm/s and 1,168.4 W/cm/s with standard deviation of ± 665.011 W/cm/s was administered to the external saphenous vein. Pain along the saphenous path was the most common side effect, with eight cases (21.05%), followed by one case of paresthesia (2.63%). Conclusions The total occlusion rate at 1-year follow-up suggests the technique is promising and is currently applicable in this sample. The incidence of pain and paresthesia may be caused by the high mean energy delivered in some cases. It is recommended that multicenter studies be conducted with larger and more uniform samples in terms of their Clinical-Etiological-Anatomical-Pathological classifications.

Resumo Contexto O uso do endolaser para doença venosa crônica envolve a escolha do comprimento de onda, fibra óptica e energia dispensada. Sua eficácia é avaliada pela taxa de oclusão venosa e, a segurança, pelos efeitos colaterais. Objetivos Demonstrar a incidência de oclusões venosas totais de veias safenas pós-endolaser no seguimento de 1 ano. Descrever a incidência e os efeitos colaterais e a necessidade de reintervenção ou complemento da terapêutica no pós-operatório. Métodos Estudo observacional retrospectivo de uma coorte com abordagem quantitativa de pacientes com insuficiência das veias safenas tratados com laser ablação endovenosa de 1.470 nm. Dados cadastrados em planilha MS Excel 2019, com cálculos de médias e desvios padrão pelo suplemento Power Query do Software. Resultados Foram elegíveis para o estudo 38 pacientes e 104 segmentos venosos, dos quais 100% estavam ocluídos em 30 dias e 99,04% em 1 ano pós-procedimento. O Linear Endovenous Energy Density médio para safena interna foi de 2.040,52 W/cm/s com desvio padrão ± 1.510,06 W/cm/s e 1.168,4 W/cm/s com desvio padrão de ± 665,011 W/cm/s para safena externa. Dor no trajeto da safena foi o principal efeito colateral, com oito casos (21,05%), seguido de parestesia, com um caso (2,63%). Conclusões Taxa de oclusão total no seguimento de 1 ano sugerindo técnica promissora e com atual aplicabilidade na amostra. A incidência da dor e parestesia podem ser justificadas pela alta média de energia utilizada em alguns casos. Recomenda-se a realização de estudos multicêntricos, com amostras maiores e mais homogêneas em relação à classificação Clínica-Etiológica-Anatômica-Patológica.

ABSTRACT. Multi-trait multi-environment (MTME) models were fitted to eucalyptus breeding trials data to assess residual variance structure, genetic stability and adaptability. To do so, 215 eucalyptus clones were evaluated in a randomized complete block design with 30 replicates and one plant per plot in four environments. At 36 months of age, tree diameter at breast height (DBH) and pilodyn penetration (PP) were measured. Two MTME models were fitted, for which residuals were considered homoscedastic and heteroscedastic, with the best MTME model selected using Bayesian information criterion. The harmonic mean of the relative performance of the genotypic values (HMRPGV) was used to determine stability and adaptability. Of the two models, the heteroscedastic MTME model had better fit and provided greater accuracy. In addition, genotype-by-environment interaction was complex, and there was low genetic correlation between DBH and PP. Rank correlation between the clones selected by the MTME models was high for DBH but low for PP. The HMRPGV facilitated clone selection through simultaneous evaluation of stability, adaptability, and productivity. Thus, our results suggest that heteroscedastic MTME model / HMRPGV can be efficiently applied in the genetic evaluation and selection of eucalyptus clones.

Abstract The aim of the present study was to evaluate semen cryopreservation with ACP-Lact® diluent, which consists of coconut water powder (ACP) added to goat milk powder. After thawing, the samples were evaluated for sperm kinetics, membrane evaluation and in vivo insemination. For cryopreservation, a pool was made with the ejaculate of six goats, diluted in four equal aliquots for the respective treatments: T1 (ACP-Lact®); T2 (ACP-Lact® 50%); T3 (ACP + 2.5% egg yolk) and T4 (Tris + 2.5% egg yolk). After dilution of the treatments, the samples were placed in 0.5 ml straws and chilled at a rate of -1.07°C/min. After reaching 4°C and stabilizing for one hour, the straws were placed in nitrogen vapour at -60°C for 15 minutes and then immersed in liquid nitrogen (-196ºC). The straws were thawed in a 37°C water bath and kinetic assessments were performed immediately using a computerized semen analysis program (CSA), viability (EN), membrane functionality (HOST), mitochondrial activity (DAB) and DNA integrity assessment of spermatozoa. For the in vivo experiment, ten goats were inseminated, divided into two groups of five goats each, G1 inseminated with ACP-Lact® and G2 with ACP, by fixed-time artificial insemination (FTAI). Regarding the kinetic parameters, the ACP-Lact® treatment showed higher progressive motility (PM) and sperm velocity than the other treatments (36.77%). In the VSL parameter the ACP-Lact diluent was superior to ACP and Tris. In viability the treatment with ACP-Lact® was superior to the treatment with Tris, 95% and 83% respectively. In FTAI two goats were born out of the 5 goats inseminated with ACP-Lact®. It was concluded that the use of ACP-Lact® for cryopreservation of caprine semen is efficient in maintaining seminal parameters during thawing in vitro and in vivo and proved to be a good alternative extender for the caprine species.