Abstract Over the last three decades, stroke care has undergone significant transformations mainly driven by the introduction of reperfusion therapy and the organization of systems of care. Patients receiving treatment through a well-structured stroke service have a much higher chance of favorable outcomes, thereby decreasing both disability and mortality. In this article, we reviewed the scientific evidence for stroke reperfusion therapy, including thrombolysis and thrombectomy, and its implementation in the public health system in Brazil.

Resumo Nas últimas três décadas, o tratamento do AVC sofreu transformações significativas, impulsionadas principalmente pela introdução das terapias de reperfusão e pela organização dos serviços de AVC. Os pacientes que recebem tratamento em um serviço de AVC bem estruturado têm uma probabilidade muito maior de resultados favoráveis, diminuindo assim a incapacidade funcional e a mortalidade. Neste artigo, revisamos as evidências científicas para as terapias de reperfusão do AVC, incluindo trombólise e trombectomia e sua implementação no sistema público de saúde no Brasil.

ABSTRACT Inside the Brazilian semi-arid region (Caatinga biome) there are vegetation refuges from other biomes that are present mainly at greater elevations in ancient geological formations such as Chapada do Araripe. This study aimed to understand the structure, diversity and floristic similarity of a fragment of humid forest in order to support conservation strategies for this community in Chapada do Araripe, southern Ceará (708m Alt.), an area of relevant ecological, cultural and scenic value. In 13 parcels of 25x25m (0.8 ha) all individuals with DBH ≥ 5cm were inventoried, observing total height. Floristic similarity was observed using the Jaccard method, comparing it with seven other areas in different regions of the Brazil. Sixty-six species were found distributed in 34 families, in a total of 1,544 individuals with DA=1,997.30 ind.ha-1 and AB =32,618 m²ha-1. Fabaceae (25.75%) and Myrtaceae (6%) had the highest number of species and Brosimum gaudichaudii had the highest IVI. The Shannon index (H') was 3.13 and the Pielou equability (J') was 0.75. The beta diversity, compared with other areas of humid forest (core and disjunct), was considered high and the statistics showed greater similarity with the area of the mesoregion of Pernambuco forest. The results allow the characterization of the area as a vegetational refuge of humid forest, corroborating the Refuge Theory and showing strong penetration of savanna species (“Cerradão”, Cerrado, Caatinga/“Carrasco”), emphasizing the action of climatic impulses that occurred in the Quaternary and pointing to the need to conservation strategies due to accelerated anthropism.

RESUMO No interior da região semiárida brasileira (bioma Caatinga), há ocorrência de refúgios de vegetação de outros biomas que se apresentam principalmente em topos de formações geológicas do período Pré-Cambriano, como a Chapada do Araripe. Este trabalho objetivou o conhecimento da estrutura, diversidade e similaridade florística de um fragmento de mata úmida na Chapada do Araripe, sul do Ceará (708m Alt.), visando subsidiar estratégias de conservação dessa comunidade, área de relevante valor ecológico, cultural e paisagístico. Em 13 parcelas de 25x25m (0,8 ha), foram inventariados todos os indivíduos com DAP ≥ 5cm, observando-se altura total. A similaridade florística foi observada pelo método de Jaccard a partir da comparação com outras sete áreas em diferentes regiões do Brasil. Foram encontradas 66 espécies distribuídas em 34 famílias, num total de 1.544 indivíduos com DA=1.997,30 ind.ha-1 e AB=32,618 m²ha-1. Fabaceae (25,75%) e Myrtaceae (6%) apresentaram maior número de espécies e Brosimum gaudichaudii apresentou maior IVI. O índice de Shannon (H’) foi 3,13 e a equabilidade de Pielou (J’) foi 0,75. A diversidade beta, comparada com outras áreas de mata úmida (core e disjuntas), foi considerada alta e a estatística apontou maior similaridade com área da mesorregião da mata pernambucana. Os resultados permitem caracterizar a área como refúgio vegetacional de mata úmida, corroborando com a teoria dos refúgios e evidenciam forte penetração de espécies savânicas (cerradão, cerrado, caatinga/carrasco) enfatizando a atuação de impulsos climáticos ocorridos no Quaternário e apontando para a necessidade de estratégias de conservação devido ao antropismo acelerado.

Abstract Background Evaluation and treatment of primary and secondary headaches is a global public health challenge. Recognizing the epidemiological impact of headaches, a group of researchers linked to the Brazilian Headache Society proposed the Brazilian Headache Registry and drew up its initial protocol. Objective Here we describe the methods and preliminary data obtained from the pilot study. Methods This was a multicenter longitudinal observational study conducted between September 2020 and August 2021. Prospective data were collected in three specialist centers for headache care in states in southern and southeastern Brazil. Patients aged 18 years or older who sought care for headache in tertiary centers and who agreed to participate in the study, were considered eligible. Results Sixty-six patients were included in the pilot study: 43 (65%) from Rio Grande do Sul state and 23 (35%) from Minas Gerais state. Overall, 90% were female, and the subjects' mean age was 38.2 ± 11.2 years. Primary headaches accounted for 85.3% of the diagnoses made. Among secondary headaches, medication overuse headache was the most frequent type (7.1%). Conclusions The pilot study showed the feasibility of the research protocol developed for tertiary centers. The Brazilian Headache Registry will form a source of longitudinal data with the aim of contributing to better characterization of the various phenotypes of patients with primary and secondary headaches, and to detailing the use of health resources and identifying predictors of better clinical outcomes.

Resumo Antecedentes A avaliação e o tratamento das cefaleias primárias e secundárias são um desafio global de saúde pública. Reconhecendo o impacto epidemiológico das cefaleias, um grupo de pesquisadores vinculados à Sociedade Brasileira de Cefaleia propôs a criação de um Registro Brasileiro de Cefaleia e elaborou seu protocolo inicial. Objetivo Nesta publicação descrevemos os métodos e dados preliminares obtidos a partir do estudo piloto. Métodos Trata-se de um estudo prospectivo observacional longitudinal multicêntrico, realizado entre setembro de 2020 e agosto de 2021. Foram coletados dados em três centros especializados no atendimento de cefaleia, em estados da região sul e sudeste do Brasil. Pacientes com idade igual ou superior a 18 anos que procuraram os centros terciários por queixa de cefaleia e concordaram em participar do estudo foram considerados elegíveis. Resultados Sessenta e seis pacientes foram incluídos no estudo piloto, 43 (65%) do Rio Grande do Sul e 23 (35%) de Minas Gerais. Da amostra total, 90% eram do sexo feminino e a idade média dos sujeitos foi de 38,2 ± 11,2 anos. As cefaleias primárias representaram 85,3% dos diagnósticos realizados. Entre as cefaleias secundárias, a cefaleia por uso excessivo de medicamentos foi a mais frequente (7,1%). Conclusões O estudo piloto evidenciou a viabilidade do protocolo de pesquisa desenvolvido para centros terciários. O Registro Brasileiro de Cefaleia constituirá uma fonte de dados longitudinais com o objetivo de contribuir para melhor caracterização dos diversos fenótipos de pacientes com cefaleias primárias e secundárias, detalhar o uso de recursos de saúde e identificar preditores de melhores desfechos clínicos.

Resumen En la región semiárida de Paraíba, el caupí es el principal producto de la agricultura familiar. El cultivo tiene baja productividad debido a lluvias irregulares y condiciones climá ticas desfavorables. Además, la productividad también se ve afectada por el uso deficiente de las tecnologías de producción. Con el objetivo de superar estas limitaciones y aumentar la eficiencia de la selección de cultivares superiores, se llevó a cabo un extenso estudio utili zando modelos biométricos en caupí. Este primer trabajo tuvo los siguientes objetivos: i. Cuantificar los efectos directos e indirectos de los componentes primarios y secundarios en la producción de granos; ii. Identificar variables con mayor potencial para la selección de cultivares de caupí en la región semiárida de Paraíba y iii. Determinar las estrategias de selección más adecuadas para el conjunto de variables evaluadas. El experimento se llevó a cabo en un campo experimental en el Centro de Ciencia y Tecnología Agroalimentaria de la Universidad Federal de Campina Grande. Se evaluó la influencia de 6 componentes primarios y 6 componentes secundarios de la producción sobre la variable rendimiento de grano. Los datos se sometieron a ANAVA y se estimaron parámetros genéticos. También se realizaron correlaciones y análisis de ruta. Se identificaron variables con mayor potencial para la selección de cultivares superiores de caupí en la región semiárida de Paraíba. Se encontró que la variable rendimiento de vaina es la más prometedora para la selección de cultivares con mayor rendimiento de grano debido a la magnitud de los efectos fenotípico y genotípico. La selección directa y la selección simultánea son las estrategias más adecuadas para el conjunto de variables evaluadas. Sin embargo, para maximizar las ganancias gené ticas, se continuó el estudio a través de índices de selección.

Abstract In the semi-arid region of Paraíba, cowpea has low productivity due to irregular rainfall and poor use of production technologies. An extensive study aimed at selecting more productive cultivars was conducted using biometric models. This first work had the following objectives: i. Quantify direct and indirect effects of primary and secondary compo nents on grain production; ii. Identify variables with greater potential for cultivar selection in the semiarid region of Paraíba and iii. Determine the most appropriate selection strat egies for the evaluated variables. The experiment was conducted in an experimental field. The influence of 6 primary and 6 secondary production components was evaluated on grain yield. Data were subjected to ANOVA. Genetic parameters, correlations and path analysis were estimated. Given the strong direct phenotypic and genotypic effects, pod yield results the most promising variable for higher grain yield selection. Direct and simultaneous selec tions are the most suitable strategies for the set of evaluated variables. However, further studies on selection indices are necessary to maximize genetic gains.

Resumen En la región semiárida de Paraíba, el caupí (Vigna unguiculata (L.) Walp) es el prin cipal producto de la agricultura familiar. El cultivo tiene baja productividad debido a lluvias irregulares y al uso de cultivares de baja productividad. Con el objetivo de superar estas limitaciones y aumentar la eficiencia de la selección de cultivares superiores, se llevó a cabo un extenso estudio utilizando modelos biométricos en caupí, con los siguientes obje tivos: i. Estimar las ganancias genéticas de los componentes de la producción; ii. Identi ficar el modelo de índice de selección que proporciona las mayores ganancias mediante la selección simultánea de un conjunto de variables y iii. Seleccionar cultivares con mayor productividad. El experimento se llevó a cabo en el campo experimental del Centro de Ciencia y Tecnología Agroalimentaria de la Universidad Federal de Campina Grande. Se evaluaron 13 variables relacionadas con la productividad. Los datos se sometieron a ANOVA y las medias se agruparon según la prueba de Scott y Knott p≤ 0,05. También se estimó el coeficiente de heredabilidad de cada variable. Las ganancias genéticas se estimaron utili zando las siguientes metodologías: respuesta correlacionada, índice de selección clásico, suma de rango e índice basado en las ganancias deseadas. Se encontró que la selección directa del componente de rendimiento de la vaina secundaria proporciona ganancias genéticas significativas en rendimiento de grano. Entre las metodologías utilizadas, el índice de selección clásico proporcionó una mayor distribución de las ganancias genéticas para rendimiento de grano y para los componentes primarios de producción. Estos resultados permiten concluir que los cultivares Costela de vaca, BRS Marataoã y Paulistinha pueden seleccionarse para cultivo y explotación en la región semiárida de Paraíba.

Abstract Low cowpea productivity (Vigna unguiculata (L.) Walp) in the semi-arid region of Paraíba is due, among other factors, to poor-quality cultivars. This research tested biometric models intending to increase productivity of superior cultivars with the following objectives: i. Estimate genetic gains in production components; ii. Identify the selection index model providing the greatest gains through simultaneously selecting a set of variables, and iii. Select cultivars with higher productivity. The experiment was carried out in the experimental field of the Agrifood Science and Technology Center of the Federal University of Campina Grande. Eight cultivars and 13 variables were evaluated. Data were subjected to ANOVA and means were grouped using the Scott and Knott test. Genetic gains were estimated by correlated response, classic selection index, rank sum and index based on desired gains. Direct selection of the secondary pod yield component provides significant genetic gains in main grain yield. Among the methodologies used, the classic selection index provided greater distribution of genetic gains for main grain yield and primary production components. These results allow concluding that Costela de vaca, BRS Marataoã and Paulistinha cultivars should be selected for cultivation and commercial exploitation in the semiarid region of Paraíba.

ABSTRACT Understorey herbs form a diverse and understudied plant assemblage in tropical forests. Although several studies and research teams have long been dedicated to the study of this conspicuous vegetation component in Amazonia, no effort to unify the data has been undertaken to date. In contrast to trees and other life forms for which major data compilations already exist, a unified database dedicated to herbs is still lacking. Part of the problem is in defining what is a herb and how to effectively sample herb assemblages. In this article, we describe the database HERBase, an exhaustive compilation of published and unpublished data on herb inventories in Amazonia. We also describe the structure, functioning, and guidelines for data curation and integration in HERBase. We were able to compile information from 1381 plots from all six Amazonian geographic regions. Based on this dataset, we describe and discuss sampling and knowledge gaps, priority areas for new collections, and recommend sampling protocols to facilitate data integration in the future. This novel database provides a unique biodiversity data repository on understorey herbs that will enable new studies on community ecology and biogeography.

RESUMO As ervas do sub-bosque formam um componente diversificado e pouco estudado em florestas tropicais. Embora vários estudos e grupos de pesquisa tenham se dedicado ao estudo desse componente conspícuo na Amazônia, nenhum esforço foi feito até o momento para unificar essas informações. Em contraste com árvores e outros grupos de plantas para os quais já existem grandes compilações de dados, uma base de dados unificada dedicada às ervas ainda não existe. Parte do problema está em definir o que é uma erva e como amostrar comunidados de ervas de forma eficiente. Neste artigo descrevemos a base de dados HERBase, uma compilação exaustiva de dados publicados e não publicados sobre inventários de ervas na Amazônia. Também descrevemos a estrutura, funcionamento e diretrizes para curadoria e integração de dados na HERBase. Conseguimos compilar informações de 1381 parcelas de todas as seis regiões geográficas amazônicas. Com base nesses dados, descrevemos e discutimos lacunas de amostragem e conhecimento, apontamos áreas prioritárias para novas coletas e recomendamos protocolos de amostragem para facilitar a integração de dados no futuro. Essa nova base de dados fornece dados únicos de biodiversidade sobre ervas do sub-bosque que permitirão novos estudos sobre ecologia e biogeografia de comunidades.

Abstract Knowledge Translation (KT) provides technologies that can be used to operationalize the collaboration between university and society for evidence-informed policy-making in response to health needs. Based on the formation of a working group (one of the available KT technologies) and to understand the health needs of Primary Health Care (PHC) workers in the city of São Paulo, this study aimed to report the experience of problematization and instrumentalization carried out with researchers, managers and PHC workers of the city of São Paulo. The Historical and Dialectical Materialism oriented the process of emancipatory workshops with the participants. The problems faced by the workers were raised and workshops and seminars were held to provide knowledge according to the needs of the group of participants. In the process of understanding the health needs of PHC workers the participants related the forms of work organization to the workers' wear out, which was emphasized by the group. The formation of the group was strategic to reach the objective and also to direct the research on the answers to the health needs of workers in the area, the next stage of the KT.

Resumo A Tradução do Conhecimento (TC) disponibiliza tecnologias que podem ser empregadas na operacionalização da integração entre universidade e sociedade, para a formulação de políticas informadas por evidências, em resposta a necessidades em saúde. A partir da formação de um grupo de trabalho - uma das tecnologias de TC disponíveis - e para compreender as necessidades em saúde dos trabalhadores inseridos na Atenção Básica (AB), este estudo objetivou relatar a experiência de problematização e instrumentalização realizada com pesquisadores, gestores e trabalhadores da AB no município de São Paulo. O referencial do Materialismo Histórico e Dialético conduziu o processo de realização de oficinas emancipatórias com os participantes. Dessa forma, foram levantados problemas enfrentados pelos trabalhadores, e realizados workshops e seminários de instrumentalização, de acordo com as necessidades do grupo de participantes. No processo de compreensão das necessidades em saúde dos trabalhadores da AB, os participantes relacionaram as formas de organização do trabalho aos desgastes dos trabalhadores, o que foi enfatizado pelo grupo. A formação do grupo foi estratégica para alcançar o objetivo, bem como direcionar a pesquisa sobre as respostas às necessidades em saúde dos trabalhadores na área, etapa seguinte da TC.

ABSTRACT Toxoplasmosis is an infection of vast worldwide distribution whose etiologic agent is Toxoplasma gondii. This disease can cause problems ranging from mild symptoms to serious conditions, such as encephalitis, miscarriage and blindness. Therefore, it is of utmost importance to perform a diagnosis with reproducible techniques in order to obtain a good prognosis. The aim of this review was to analyze the efficiency of toxoplasmosis diagnostic techniques based on sensitivity and specificity results. Five research platforms in English language were used (Eric, Elsevier, Google Scholar, PubMed and SciELO), which contained data on the diagnosis of toxoplasmosis. The search and selection were performed for studies published prior to June 2021. The search resulted in the inclusion of 13 articles published from 2005 to 2020. The data revealed the use of different samples in the standardization of techniques such as serum, total blood, colostrum and amniotic fluid. The flow cytometry, lateral flow immunoassay and qPCR techniques showed 100% sensitivity, whereas the ELISA, western blotting, qPCR and RE-LAMP techniques achieved 100% specificity. Significantly, the qPCR and LAMP techniques were more accurate when the likelihood ratio was assessed. The meta-analysis identified that ISAGA and western blotting have low sensitivity values and LIASON, ELFA and ELISA, using a silica bioconjugate, also have low specificity values. It was noted that a wide range of methods have high values of sensitivity and specificity. Therefore, the choice of the method will be based on the conditions and its financial viability.

Abstract Objective: Identify the one-year survival rate and major complications in patients submitted to pneumonectomy for infectious disease. Methods: Retrospective data from all cases of infectious disease pneumonectomy over the past 10 years were collected from two reference centers. The authors analyzed: patient demographics, etiology, laterality, bronchial stump treatment, presence of previous pulmonary resection, postoperative complications in the first 30 days, the treatment used in pleural complications, and one-year survival rate. Results: 56 procedures were performed. The average age was 44 years, with female predominance (55%). 29 cases were operated on the left side (51%) and the most frequent etiology was post-tuberculosis (51.8%). The overall incidence of complications was 28.6% and the most common was empyema (19.2%). Among empyema cases, 36.3% required pleurostomy, 27.3% required pleuroscopy and 36.3% underwent thoracoplasty for treatment. Bronchial stump fistula was observed in 10.7% of cases. From all cases, 16.1% were completion pneumonectomies and 62.5% of these had some complication, a significantly higher incidence than patients without previous surgery (p = 0.0187). 30-day in-hospital mortality was (7.1%) with 52 cases (92.9%) and 1-year survival. The causes of death were massive postoperative bleeding (1 case) and sepsis (3 cases). Conclusions: Pneumonectomy for benign disease is a high-risk procedure performed for a variety of indications. While morbidity is often significant, once the perioperative risk has passed, the one-year survival rate can be very satisfying in selected patients with benign disease.

ABSTRACT This study analyzed the timed up and go test (TUG) as a tool to evaluate muscle strength in community-dwelling older people. As a methodology, an observational, cross-sectional and analytical study was conducted. Data from 442 older people were analyzed, both women (71.7%) and men (28.3%). Ages ranged from 62- 104 years, with a mean of 80.85 (±8.047) years. TUG was used as a tool to evaluate muscle strength. Comparison and correlation analyses were performed to compare performance between the TUG and the chair stand test (CST) and between TUG and handgrip strength (HGS). Analysis of agreement between the diagnosis of low physical performance on TUG and the diagnosis of muscle weakness on CST and HGS was also performed. The predictive values were estimated using the receiver operating characteristic curve. The analyses showed a moderate direct proportional correlation between TUG and CST performance and low inversely proportional correlations between TUG and HGS performance and between CST and HGS (p<0.001). In the accuracy analyses, it was observed that TUG test could predict muscle strength in CST (S 34.4%; PPV 91.5%; NPV 26.1%; AUC=0.779; 95%CI 0.724-0.835; p<0.001) and handgrip dynamometry (S 44.2%; PPV 77.4%; NPV 67.2%; AUC=0.652; 95%CI 0.599-0.705; p<0.001). The Timed Up and Go test was able to satisfactorily indicate individuals with normal muscle strength in CST.

RESUMEN Este estudio analizó el uso de la prueba de levantarse y andar (TUG) como una herramienta para evaluar la fuerza muscular en adultos mayores residentes en la comunidad. Como metodología, se trata de un estudio observacional, transversal y analítico. Se analizaron datos de 442 ancianos, del sexo femeninol(71,7%) y masculino (28,3%), de edad de entre 62 y 104 años, y edad media de 80,85 (±8,047) años. El instrumento TUG se utilizó para evaluar la fuerza muscular. Se realizaron análisis de comparación y correlación entre el rendimiento en TUG y en la prueba de sentarse y levantarse (SL), y entre TUG y la fuerza de agarre. También se realizaron análisis de concordancia entre el diagnóstico de bajo rendimiento físico en TUG y el diagnóstico de debilidad muscular en SL y fuerza de agarre. Los valores predictivos se trazaron utilizando la curva receiver operating characteristic (ROC). Hubo una correlación directamente proporcional moderada entre el rendimiento de TUG y de SL, y se encontraron correlaciones inversamente proporcionales bajas entre el rendimiento de TUG y la fuerza de agarre, así como entre SL y la fuerza de agarre (p<0,001). En los análisis de precisión se observó que TUG fue capaz de predecir la fuerza muscular en SL (S 34,4%; VPP 91,5%; VPN 26,1%; AUC=0,779; IC 95% 0,724-0,835; p<0,001) y en la dinamometría de agarre (S 44,2%; VPP 77,4%; VPN 67,2%; AUC=0,652; IC 95% 0,599-0,705; p<0,001). Se concluye que TUG fue capaz de indicar satisfactoriamente a los individuos con fuerza muscular normal en SL.

RESUMO Este estudo analisou o uso do timed up and go test (TUG) como ferramenta de avaliação da força muscular em idosos da comunidade. Como metodologia, foi realizado um estudo observacional, transversal e analítico. Foram analisados dados de 442 idosos, do sexo feminino (71,7%) e do masculino (28,3%), com idades entre 62 e 104 anos, e média de 80,85 (±8,047) anos. O TUG foi utilizado como instrumento de avaliação da força muscular. Foram realizadas análises de comparação e correlação entre o desempenho no TUG e no teste de sentar e levantar (TSL), e entre o TUG e a força de preensão manual. Também foram realizadas análises de concordância entre diagnóstico de baixo desempenho físico no TUG e diagnóstico de fraqueza muscular no TSL e na força de preensão manual. Os valores preditivos foram traçados por meio da curva receiver operating characteristic (ROC). As análises mostraram correlação diretamente proporcional moderada entre o desempenho no TUG e no TSL e correlações inversamente proporcionais baixas entre o desempenho no TUG e a força de preensão manual e entre o TSL e a força de preensão manual (p<0,001). Nas análises de acurácia, observou-se que o TUG apresentou capacidade de prever a força muscular no TSL (S 34,4%; VPP 91,5%; VPN 26,1%; AUC=0,779; 95% IC 0,724-0,835; p<0,001) e na dinamometria de preensão palmar (S 44,2%; VPP 77,4%; VPN 67,2%; AUC=0,652; 95% IC 0,599-0,705; p<0,001). Conclui-se que o TUG apresentou capacidade de indicar de forma satisfatória os indivíduos com força muscular normal no TSL.

Abstract Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to produce standardized extracts has not been investigated. This study analyzes the influence of spray drying parameters on the contents of the chemical markers (total phenolic, total flavonoid, and hibalactone) and the functional properties of H. umbellata extract. The optimization of drying conditions was performed using a central composite design combined with response surface methodology and desirability function approach. The mathematical models fitted to experimental data indicated that all the evaluated drying parameters significantly influenced the chemical contents. The optimal conditions were: inlet temperature of 120 °C, feed flow rate of 4 mL min-1, and colloidal silicon dioxide:maltodextrin ratio of 16%:4%. Under these conditions, the powder samples had spherical particles and desirable physicochemical and functional properties, such as low water activity and moisture content, good product recovery, reconstitution, and flowability. Thus, spray drying might be a promising technique for processing standardized H. umbellata extracts.

Abstract The aim of this study was to evaluate the time elapsed from first symptoms to the treatment of oral and oropharyngeal cancer (OOC) and to identify variables associated with treatment delay. This is an observational study with retrospective and prospective data collection. Patients with a diagnosis of OOC seen at the Head and Neck Surgery outpatient clinic of a Brazilian public hospital were included and followed up to treatment initiation. Participants answered a questionnaire for the collection of socioeconomic, demographic, cultural, and clinical information, as well as information about the time elapsed from first symptoms to the first appointment with a head and neck surgeon. Time to treatment was classified into four intervals: 1- first symptoms to first medical appointment; 2- first medical appointment to specialized medical care; 3- specialized medical care to preparation for treatment; and 4- preparation for treatment to treatment initiation. Bivariate statistics were computed. Out of 100 participants, nine died before treatment. Mean time to treatment was 217 days. Highest mean time was observed for interval 2 (94 days), followed by interval 1 (63 days), interval 4 (39 days), and interval 3 (21 days). At interval 1, a longer time was associated with severe alcohol consumption, severe smoking, and family history of cancer. At interval 2, the delay was associated with appointment with a general practitioner, clinical diagnosis of disease other than cancer, and antibiotic prescription. At interval 4, delay in treatment was associated with surgical treatment. Patients with OOC experience delays from symptom onset to treatment initiation. The longest interval was associated with professional delay, followed by patient delay in help-seeking.

Abstract Knowledge Translation (KT) provides technologies that can be used to operationalize the collaboration between university and society for evidence-informed policy-making in response to health needs. Based on the formation of a working group (one of the available KT technologies) and to understand the health needs of Primary Health Care (PHC) workers in the city of São Paulo, this study aimed to report the experience of problematization and instrumentalization carried out with researchers, managers and PHC workers of the city of São Paulo. The Historical and Dialectical Materialism oriented the process of emancipatory workshops with the participants. The problems faced by the workers were raised and workshops and seminars were held to provide knowledge according to the needs of the group of participants. In the process of understanding the health needs of PHC workers the participants related the forms of work organization to the workers' wear out, which was emphasized by the group. The formation of the group was strategic to reach the objective and also to direct the research on the answers to the health needs of workers in the area, the next stage of the KT.

Resumo A Tradução do Conhecimento (TC) disponibiliza tecnologias que podem ser empregadas na operacionalização da integração entre universidade e sociedade, para a formulação de políticas informadas por evidências, em resposta a necessidades em saúde. A partir da formação de um grupo de trabalho - uma das tecnologias de TC disponíveis - e para compreender as necessidades em saúde dos trabalhadores inseridos na Atenção Básica (AB), este estudo objetivou relatar a experiência de problematização e instrumentalização realizada com pesquisadores, gestores e trabalhadores da AB no município de São Paulo. O referencial do Materialismo Histórico e Dialético conduziu o processo de realização de oficinas emancipatórias com os participantes. Dessa forma, foram levantados problemas enfrentados pelos trabalhadores, e realizados workshops e seminários de instrumentalização, de acordo com as necessidades do grupo de participantes. No processo de compreensão das necessidades em saúde dos trabalhadores da AB, os participantes relacionaram as formas de organização do trabalho aos desgastes dos trabalhadores, o que foi enfatizado pelo grupo. A formação do grupo foi estratégica para alcançar o objetivo, bem como direcionar a pesquisa sobre as respostas às necessidades em saúde dos trabalhadores na área, etapa seguinte da TC.

ABSTRACT Background: classical models of microsurgical anastomosis training are expensive and have ethical implications. Some alternatives join low cost and easiness to store. However, the translation of knowledge acquired by training in these methods into the traditional ones is not clear. This project aims to assess the feasibility of konjac noodles as a reliable microsurgery-training model. Methods: 10 neurosurgery residents performed an end-to-end anastomosis in a 2-3mm placenta artery. The anastomoses were evaluated quantitatively, recording time; and qualitatively, applying a validated score (Anastomosis Lapse Index - ALI) by three experienced neurosurgeons and verifying the presence of gross leakage through the infusion of fluorescein. Subsequently, they performed 10 non-consecutive sessions of anastomosis training in the konjac noodle. Eventually, a final anastomosis in the placenta model was performed and the same parameters were scored. Results: we observed a 17min reduction in the mean time to perform the anastomosis in the placenta model after the training in the konjac (p<0.05). There was a non-significant 20% reduction in gross leakage, but the training sessions were not able to consistently improve the ALI score. Conclusions: we demonstrate a reduction in anastomosis performing time in placental arteries after training sessions in the konjac noodle model, which can be regarded as a feasible low-cost method, particularly useful in centers with surgical microscopes only in the operation room.

ABSTRACT Introdução: modelos tradicionais de treinamento de anastomose microcirúrgica costumam ter custos elevados e implicações éticas de aquisição e manutenção, buscando-se alternativas que reúnam baixo custo e facilidade de armazenamento. Existem diferentes propostas, porém há poucas evidências de que conhecimentos adquiridos com o treinamento nessas plataformas se traduza em melhora na performance, quando estes são comparados a modelos consagrados. Este projeto objetiva avaliar a viabilidade do macarrão de konjac como modelo confiável de treinamento microcirúrgico. Métodos: 10 residentes de neurocirurgia realizaram uma anastomose término-terminal em artéria placentária humana de 2-3mm. As anastomoses foram avaliadas quantitativamente, registrando-se o tempo de confecção e qualitativamente, aplicando-se um escore validado (Anastomosis Lapse Index – ALI) por neurocirurgiões experientes e verificando-se a presença de vazamento grosseiro através da visualização no modo fluorescente injetando-se fluoresceína. Subsequentemente, realizaram 10 sessões de treinamento não consecutivos de anastomose términoterminal no modelo de konjac. Por fim, uma anastomose final foi realizada no modelo placentário e os mesmo parâmetros reavaliados. Resultados: observamos uma redução de 17 min no tempo médio de confecção da anastomose no modelo de placenta após os treinos no modelo do macarrão (p<0.05). Houve uma redução não significativa de 20% no vazamento grosseiro. As sessões de treino no macarrão não foram capazes de melhorar consistentemente o score ALI. Conclusão: o treinamento em modelo de macarrão konjac é capaz de reduzir o tempo para realização das anastomoses no modelo em placenta humana, mostrando-se alternativa viável de baixo custo e manutenção, útil em serviços que disponham de microscópio apenas no ambiente cirúrgico.