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Resumo Fundamento: A análise prognóstica multivariada tem sido realizada tradicionalmente por modelos de regressão. No entanto, muitos algoritmos surgiram, capazes de traduzir uma infinidade de padrões em probabilidades. A acurácia dos modelos de inteligência artificial em comparação à de modelos estatísticos tradicionais não foi estabelecida na área médica. Objetivo: Testar a inteligência artificial como um algoritmo preciso na predição de doença coronariana no cenário de dor torácica aguda, e avaliar se seu desempenho é superior a do modelo estatístico tradicional. Métodos: Foi analisada uma amostra consecutiva de 962 pacientes admitidos com dor torácica. Dois modelos probabilísticos de doença coronariana foram construídos com os primeiros 2/3 dos pacientes: um algoritmo machine learning e um modelo logístico tradicional. O desempenho dessas duas estratégias preditivas foi avaliado no último terço de pacientes. O modelo final de regressão logística foi construído somente com variáveis significativas a um nível de significância de 5%. Resultados: A amostra de treinamento tinha idade média de 59 ± 15 anos, 58% do sexo masculino, e uma prevalência de doença coronariana de 52%. O modelo logístico foi composto de nove preditores independentes. O algoritmo machine learning foi composto por todos os candidatos a preditores. Na amostra teste, a área sob a curva ROC para predição de doença coronariana foi de 0,81 (IC95% = 0,77 – 0,86) para o algoritmo machine learning, similar à obtida no modelo logístico (0,82; IC95% = 0,77 – 0,87), p = 0,68. Conclusão: O presente estudo sugere que um modelo machine learning acurado não garante superioridade à um modelo estatístico tradicional

Abstract Background: Multivariate prognostic analysis has been traditionally performed by regression models. However, many algorithms capable of translating an infinity of patterns into probabilities have emerged. The comparative accuracy of artificial intelligence and traditional statistical models has not been established in the medical field. Objective: To test the artificial intelligence as an accurate algorithm for predicting coronary disease in the scenario of acute chest pain and evaluate whether its performance is superior to traditional statistical model. Methods: A consecutive sample of 962 patients admitted with chest pain was analyzed. Two probabilistic models of coronary disease were built using the first two-thirds of patients: a machine learning algorithm and a traditional logistic model. The performance of these two predictive strategies were evaluated in the remaining third of patients. The final logistic regression model had significant variables only, at the 5% significance level. Results: The training sample had an average age of 59 ± 15 years, 58% males, and a 52% prevalence of coronary disease. The logistic model was composed of nine independent predictors. The machine learning algorithm was composed of all candidates for predictors. In the test sample, the area under the ROC curve for prediction of coronary disease was 0.81 (95% CI = 0.77 - 0.86) for the machine learning algorithm, similar to that obtained in logistic model (0.82; 95% CI = 0.77 - 0.87), p = 0.68. Conclusion: The present study suggests that an accurate machine learning prediction tool did not prove to be superior to the statistical model of logistic regression.

https://doi.org/10.36660/abc.20200302 2 downloads

Corrosion Sensor Using Metallic Double Layer in Optical Fiber
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Oliveira, Hebio J. B. de

; Silva Jr, Elias A.

; Alves, Henrique P.

; Nascimento, Jehan F. do

; Vilela-Leão, Luis H.

; Gonçalves, Charlie S.

; Martins Filho, Joaquim F.

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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sep 2021, Volume 20 N. 3 Pages 513 - 525

Abstract: En | Text: En | PDF: En

Abstract In this paper, a new optical fiber corrosion sensor based on metallic bilayers is described. The detection region is located at a fiber end facet and we present simulations as well as experimental results in controlled lab conditions for Ti(10 nm)/Al(10 nm) and Ni(5 nm)/Al(5 nm) bilayers. We perform the characterization of the device by numerical simulations using the COMSOL Multiphysics software, and with an analytical model, which makes use of the Fresnel equations. According to the simulations, the change in the reflected optical signal over time is related to variations in the thickness of the metallic films by the corrosive process and, consequently, the corrosion rate in each metal of the bilayer can be obtained. Upon the simulation results, sensor devices were fabricated by depositing thin metallic films on the cleaved facet of the optical fiber using the sputtering method. We show that the use of a metallic bilayer as a transducer, instead of a monolayer, improves the sensor measuring interval (20 ± 1 nm) and provides information about the corrosion rate along the corrosion process.

https://doi.org/10.1590/2179-10742021v20i31252 54 downloads

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Abstract: En | Text: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

Chemometric-Assisted Hydrophilic Interaction Chromatographic Method for the Determination of Gadolinium-Based Magnetic Resonance Imaging Contrast Agent in Liposomes
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Maia, Ana Luiza C.

; Silva, Pedro Henrique R. da

; Fernandes, Christian

; Silva, Aline T. M. e

; Barros, André Luís B. de

; Soares, Daniel Crístian F.

; Ramaldes, Gilson A.

Journal of the Brazilian Chemical Society

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nov 2018, Volume 29 N. 11 Pages 2426 - 2440

Abstract: En | Text: En | PDF: En

Gadodiamide (Gd-DTPA-BMA) is a gadolinium (Gd) chelate composed of two carboxylate groups of diethylenetriaminepentaacetic acid (DTPA) and two amide groups (BMA). Gd complexes are the most widely used contrast agents in nuclear magnetic resonance. Furthermore, our research group has demonstrated the potential of liposomes containing Gd-DTPA-BMA for cancer therapy. The aim of this study was to develop and validate a chemometric-assisted method by hydrophilic interaction liquid chromatography (HILIC) for determination of Gd-DTPA-BMA in liposomes. The chromatographic conditions obtained were: Sequant® ZIC®-HILIC Merck (150 × 4.6 mm, 3.5 µm, 100 Å) column, mobile phase composed of 5 mmol L-1 ACN/NH4FA, pH 4.5 (60:40 v/v) at 0.6 mL min-1, injection volume of 20 µL, temperature of 30 ºC, and detection at 210 nm. The linear range was of 40 to 120 nmol mL-1. The use of chemometrics allowed obtaining optimal chromatographic parameters, in terms of signal-to-noise ratio, resolution, and asymmetry.

https://doi.org/10.21577/0103-5053.20180120 503 downloads

Compostos nitrogenados sobre o consumo alimentar de camarão-rosa Farfantepenaeus brasiliensis
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Campos, Bruno Ribeiro de

; Furtado, Plínio Schmidt

; D'Incao, Fernando

; Wasielesky, Wilson

; Poersch, Luís Henrique da Silva

Ciência Rural

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dec 2013, Volume 43 N. 12 Pages 2202 - 2207

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Os experimentos foram realizados para investigar os efeitos da amônia, nitrito e nitrato no consumo alimentar de juvenis de Farfantepenaeus brasiliensis. Os camarões com peso médio de 4g foram aclimatados durante 28 dias em diferentes concentrações crônicas de amônia, nitrito e nitrato. Após o período de exposição de 28 dias, 20 camarões por tratamento foram individualizados em unidades experimentais de 3 L, a fim de ser analisado o consumo de ração em função da quantidade de alimento oferecido e as sobras durante um período de 24 horas. O consumo alimentar apresentou alterações significativas (P<0,05) para os camarões expostos às concentrações de nitrito e nitrato testadas, enquanto para o tratamento com amônia, os camarões não apresentaram alterações no consumo alimentar (P>0,05). Foi verificado que o nitrito e o nitrato afetam o consumo alimentar de F. brasiliensis. Contudo, a possibilidade de que isso ocorra durante longos períodos, afetando negativamente o cultivo de espécies em cativeiro, reforçam a necessidade do manejo da qualidade de água.

The experiments were carried out to investigate the effects of ammonia, nitrite and nitrate on food consumption of juvenile F. brasiliensis. The juvenile shrimp were acclimated for 28 days with different cronic concentrations of ammonia, nitrite and nitrate. After the acclimation period, 20 shrimps per treatment were individualized in 3 L experimental units in order to analyze their feed intake through the amount of feed offered and leftover for a period of 24 hours. The food consumption presented significant alteration (P<0.05) for the nitrite and nitrate concentrations tested, meanwhile on ammonia treatment, shrimp presented no alteration on food intake (P>0.05). According to the results obtained, nitrite and nitrate affected F. brasiliensis food consumption. However, the possibility of this to happen over long periods, can damage the species in captivity, reinforced the necessity of regular water quality management.

1950 downloads Cited 1 time in SciELO

Classification of journals in the QUALIS System of CAPES URGENT need of changing the criteria!
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Andriolo, Adagmar

; Souza, Aécio Flávio Meireles

; Farias, Alberto Queiroz

; Barbosa, Alfredo José Afonso

; França Netto, Antonio Spina

; Hernandez, Arnaldo José

; Camargos, Aroldo F.

; Barraviera, Benedito

; Kadunc, Bogdana Victoria

; Caramelli, Bruno

; Campos, Carlos Eduardo Aguilera

; Brites, Carlos

; Nascimento, Dejair Caitano do

; Braile, Domingo M.

; Goldenberg, Dov Charles

; Baracat, Edmund Chada

; Kimura, Edna T.

; Marchiori, Edson

; Vieira, Eduardo de Paula

; Almeida, Eros Antônio de

; Jotz, Geraldo Pereira

; Camanho, Gilberto

; Friedman, Gilberto

; Cerri, Giovanni Guido

; Duarte, Ivomar Gomes

; Costa, Izelda Maria Carvalho

; Mello Júnior, João Ferreira de

; Faintuch, Joel

; Martinez, José Antônio Baddini

; Antonio Livramento, José

; Manso, José Eduardo Ferreira

; Amaral, José Luiz Gomes do

; Battistella, Linamara Rizzo

; Machado, Luís dos Ramos

; Moreira, Luiz Felipe P.

; Gebrim, Luiz Henrique

; Madeira, Marcelo

; Riberto, Marcelo

; Bastos, Marcus

; Falcão, Mário Cícero

; Conceição, Mario J. da

; Silva, Mauricio Rocha e

; Ruiz, Milton Artur

; Shibata, Milton K.

; Santiago, Mittermayer Barreto

; Andreollo, Nelson Adami

; Malafaia, Osvaldo

; Martins, Regina Helena Garcia

; Procianoy, Renato Soibelmann

; Baroudi, Ricardo

; Fuller, Ricardo

; Viebig, Ricardo Guilherme

; Nitrini, Ricardo

; Moura, Rita Cristina Mainieri R. de

; Dedivitis, Rogério

; Damião, Ronaldo

; Lianza, Sergio

; Rode, Sigmar de Mello

; Yoshida, Winston Bonetti

; Handar, Zuher

Arquivos de Neuro-Psiquiatria

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apr 2010, Volume 68 N. 2 Pages 327 - 329

Abstract: En | Text: En | PDF: En

3236 downloads Cited 9 times in SciELO

Classificação dos Periódicos no Sistema QUALIS da CAPES - a Mudança dos Critérios é URGENTE!
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Andriolo, Adagmar

; Souza, Aécio Flávio Meireles

; Farias, Alberto Queiroz

; Barbosa, Alfredo José Afonso

; França Netto, Antonio Spina

; Hernandez, Arnaldo José

; Camargos, Aroldo F.

; Barraviera, Benedito

; Kadunc, Bogdana Victoria

; Caramelli, Bruno

; Campos, Carlos Eduardo Aguilera

; Brites, Carlos

; Nascimento, Dejair Caitano do

; Braile, Domingo M.

; Goldenberg, Dov Charles

; Kimura, Edna T

; Marchiori, Edson

; Vieira, Eduardo de Paula

; Almeida, Eros Antônio de

; Jotz, Geraldo Pereira

; Camanho, Gilberto

; Friedman, Gilberto

; Cerri, Giovanni Guido

; Duarte, Ivomar Gomes

; Costa, Izelda Maria Carvalho

; Mello Júnior, João Ferreira de

; Faintuch, Joel

; Martinez, José Antônio Baddini

; Livramento, José Antonio

; Manso, José Eduardo Ferreira

; Battistella, Linamara Rizzo

; Machado, Luís dos Ramos

; Moreira, Luiz Felipe P.

; Gebrim, Luiz Henrique

; Madeira, Marcelo

; Riberto, Marcelo

; Bastos, Marcus

; Falcão, Mário Cícero

; Conceição, Mario J. da

; Rocha e Silva, Mauricio

; Ruiz, Milton Artur

; Shibata, Milton K.

; Santiago, Mittermayer Barreto

; Andreollo, Nelson Adami

; Malafaia, Osvaldo

; Martins, Regina Helena Garcia

; Procianoy, Renato Soibelmann

; Baroudi, Ricardo

; Fuller, Ricardo

; Viebig, Ricardo Guilherme

; Nitrini, Ricardo

; Moura, Rita Cristina Mainieri R. de

; Dedivitis, Rogério

; Damião, Ronaldo

; Lianza, Sergio

; Rode, Sigmar de Mello

; Yoshida, Winston Bonetti

; Handar, Zuher

Arquivos Brasileiros de Cardiologia

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mar 2010, Volume 94 N. 3 Pages 290 - 291

Abstract: Pt | Text: Pt | PDF: Pt

3995 downloads Cited 2 times in SciELO

Classificação dos periódicos no Sistema Qualis da Capes: a mudança dos critérios é urgente!
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Andriolo, Adagmar

; Barbosa, Alfredo José Afonso

; França Netto, Antonio Spina

; Hernandez, Arnaldo José

; Camargos, Aroldo F.

; Barraviera, Benedito

; Kadunc, Bogdana Victoria

; Caramelli, Bruno

; Campos, Carlos Eduardo Aguilera

; Brites, Carlos Roberto

; Braile, Domingo M.

; Goldenberg, Dov Charles

; Kimura, Edna T

; Marchiori, Edson

; Vieira, Eduardo de Paula

; Sampaio, Francisco J. B.

; Jotz, Geraldo Pereira

; Camanho, Gilberto

; Friedman, Gilberto

; Cerri, Giovanni Guido

; Duarte, Ivomar Gomes

; Costa, Izelda Maria Carvalho

; Mello Júnior, João Ferreira de

; Faintuch, Joel

; Martinez, José Antônio Baddini

; Livramento, José Antonio

; Manso, José Eduardo Ferreira

; Battistella, Linamara Rizzo

; Machado, Luís dos Ramos

; Moreira, Luiz Felipe P.

; Gebrim, Luiz Henrique

; Madeira, Marcelo

; Riberto, Marcelo

; Bastos, Marcus

; Falcão, Mário Cícero

; Silva, Mauricio Rocha e

; Ruiz, Milton Artur

; Shibata, Milton K.

; Santiago, Mittermayer Barreto

; Martins, Regina Helena Garcia

; Procianoy, Renato Soibelmann

; Baroudi, Ricardo

; Fuller, Ricardo

; Viebig, Ricardo Guilherme

; Nitrini, Ricardo

; Dedivitis, Rogério

; Damião, Ronaldo

; Lianza, Sergio

; Rode, Sigmar de Mello

; Yoshida, Winston Bonetti

; Handar, Zuher

Revista Brasileira de Hematologia e Hemoterapia

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feb 2010, Volume 32 N. 1 Pages 1 - 3

Abstract: Pt | Text: Pt | PDF: Pt

3073 downloads Cited 2 times in SciELO

Shrimp farming as an alternative to artisanal fishermen communities: the Case of Patos Lagoon, Brazil
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Cavalli, Ronaldo Olivera

; Wasielesky Jr, Wilson

; Peixoto, Silvio

; Poersch, Luís Henrique da Silva

; Santos, Marcos Henrique Silva

; Soares, Roberta Borda

Brazilian Archives of Biology and Technology

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oct 2008, Volume 51 N. 5 Pages 991 - 1001

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O camarão-rosa Farfantepenaeus paulensis é considerado uma espécie com potencial para criação no estuário da Lagoa dos Patos, RS, onde o volume desembarcado deste recurso vem decrescendo nos últimos anos. A criação deste camarão em cercados está sendo proposta como uma fonte de renda alternativa para os pescadores artesanais e agricultores que habitam o entorno deste estuário. Do ponto de vista econômico, estes sistemas alternativos de criação apresentam vantagens sobre os sistemas tradicionais em viveiros de terra: não se necessita ter posse da terra, nem equipamentos de bombeamento d'água ou aeração. Além disso, materiais relativamente baratos são utilizados na construção das estruturas de engorda e há uma grande disponibilidade de alimento natural. Esta revisão apresenta alguns aspectos da criação de F. paulensis em cercados como uma alternativa às comunidades de pescadores. Maior ênfase será dada no desenvolvimento dos sistemas de criação, manejo, impactos sociais e ambientais, dificuldades e possibilidades.

The shrimp Farfantepenaeus paulensis is considered a suitable species for culture in the Patos Lagoon estuary, southern Brazil, where its catch has been decreasing in the last few years. Considering the potential of estuarine areas for shrimp farming, the application of low-cost structures to culture shrimp, such as the pen enclosures, is being proposed as an alternative source of income for artisanal fishermen and farmers living near Patos Lagoon. From an economical standpoint, these alternative systems present several advantages over the traditional pond-based culture systems since land, water pumping and artificial aerations are not required, high natural productivity is available and inexpensive materials are employed in the construction of grow-out structures. This paper reviews the farming of F. paulensis in the pen enclosures as an alternative to the artisanal fishing communities of the Patos Lagoon estuary. Particular emphases are placed on the development of culture systems, social and environmental impacts, constraints and perspectives.

4231 downloads Cited 1 time in SciELO

10.

Influence of the temperature and type of salt on the phase equilibrium of peg 1500 + potassium phosphate and peg 1500 + sodium citrate aqueous two-phase systems
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Carvalho, Carolina P.

; Coimbra, Jane Sélia R.

; Costa, Isabele Andressa F.

; Minim, Luis Antonio

; Maffia, Maria Cristina

; Silva, Luis Henrique M.

Química Nova

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2008, Volume 31 N. 2 Pages 209 - 213

Abstract: En | Text: En | PDF: En

The present work analyzed the effect of the temperature and type of salt on the phase equilibrium of aqueous two-phase systems (ATPS) formed by poly (ethylene glycol) (PEG) 1500 + potassium phosphate, from (278.15 to 318.15) K, and PEG 1500 + sodium citrate, from (278.15 to 298.15) K. The rise of the temperature normally increased the slope of the tie line (STL). With respect to the influence of the type of salt, sodium citrate showed better capability to induce phase separation, when compared to potassium phosphate.

3120 downloads

11.

II Consenso Brasileiro de Fator Antinuclear em Células HEp-2: Definitions for standardization of autoantibody testing against the nucleus (ANA HEp-2), nucleolus, cytoplasm and mitotic apparatus, as wel as its clinical associations
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Dellavance, Alessandra

; Gabriel Júnior, Alexandre

; Cintra, Alice F. U.

; Ximenes, Antônio Carlos

; Nuccitelli, Barbara

; Taliberti, Ben Hur

; Moreira, Caio

; von Mühlen, Carlos Alberto

; Bichara, Carlos David

; Santos, Cláudio Henrique Ramos dos

; Yano, Cristiane Martinez

; Mangueira, Cristóvão Luis Pitangueira

; Carvalho, Darlene Gonçalves

; Bonfá, Eloísa Silva Dutra de O.

; Doi, Elvira M.

; Guimarães, Fabiana Nunes de Carvalho

; Araújo, Flávia Ikeda e

; Mundim, Hugo Mendonça

; Rego, Jozelia

; Vieira, Lisiane Ericonio dos Anjos

; Poli, Luciana

; Andrade, Luís Eduardo Coelho

; Callado, Maria Roseli

; Mesquita, Mauro Meira

; Sugiyama, Mitiko

; Slhessarenko, Natasha

; Silva, Nilzio Antônio da

; Carballo, Orlando Gabriel

; Leser, Paulo Guilherme

; Francescantonio, Paulo Luiz Carvalho

; Jarach, Renata

; Xavier, Ricardo Machado

; Levy, Roger Abramino

; Neves, Suzane P. F.

; Cruvinel, Wilson de Melo

; Santos, Wilton Silva dos

Revista Brasileira de Reumatologia

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jun 2003, Volume 43 N. 3 Pages 129 - 140

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: O Segundo Consenso Brasileiro de Fator Antinuclear (FAN) em Células HEp-2 ratificou os algoritmos de decisão para leitura dos padrões do FAN na imunofluorescência indireta vistos na primeira edição do Consenso Brasileiro, adicionando ainda um novo algoritmo relacionado com os padrões mistos. MÉTODOS: Tendo em vista a habilidade do teste em detectar autoantígenos nos distintos compartimentos celulares, e não apenas no núcleo, propõe-se novas denominações para este exame laboratorial. RESULTADOS E CONCLUSÕES: Como novas denominações algumas sugestões foram igualmente aceitas, dentro do tema "pesquisa de auto-anticorpos contra constituintes do núcleo (FAN HEp-2), nucléolo, citoplasma e aparelho mitótico". Foram abordadas as principais relevâncias clínicas com os padrões de FAN descritos, facilitando o melhor uso do ensaio pelo médico.

OBJECTIVE: The Second Brazilian Consensus on Antinuclear Antibodies (ANA) in HEp-2 Cells approved and extended the decision trees developed during the First Brazilian Consensus in order to also offer information about mixed patterns of fluorescence. METHODS: Since this test elicits reactions not only to nuclear autoimmune antigens but also to different cell compartments, new denominations for the test were approved. Results and CONCLUSIONS: These new denominations encompass variations on the "autoantibody testing against the nucleus (ANA HEp-2), nucleolus, cytoplasm, and mitotic apparatus" issue. Furthermore, major clinical associations were described for each immunofluorescent pattern, facilitating the interpretation of laboratory results in the clinical practice.

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Valvoplastia mitral percutânea de urgência em gestante
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Gubolino, Luiz A.

; Amaral, Fernando

; Bragalha, Antoninha M. L. de A.

; Moschini, Ronaldo

; Silva, Luis Henrique F.

; Kalafe, Amir M.

Arquivos Brasileiros de Cardiologia

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- Sobre o periódico
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jul 1997, Volume 69 N. 1 Pages 51 - 53

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Gestante com 33 anos na 28ª semana e sinais de óbito fetal foi admitida em caráter de urgência com quadro de edema pulmonar agudo secundário à estenose mitral grave. Com o insucesso do tratamento medicamentoso intensivo, a paciente foi submetida à valvoplastia mitral percutânea de emergência com melhora imediata. O agravamento subseqüente do quadro, atribuído ao óbito fetal, foi tratado através parto cesáreo com melhora clínica considerável. A paciente teve alta hospitalar no 10º dia, e 11 meses após o procedimento, encontra-se em classe funcional I, sem uso de medicação e com sinais ecocardiográficos de estenose mitral leve (área valvar: 2,0 cm²).

We report the case of a 33-year-old woman in the 28th week of pregnancy and with signs of fetal death, admitted to hospital in an emergency due to pulmonary edema secondary to severe mitral valve stenosis. Intensive medical treatment was unsuccessful and the patient was submitted to an emergency percutaneous balloon mitral valvoplasty with prompt clinical improvement. Subsequent clinical deterioration secondary to fetal death was managed by cesarean section resulting in clinical estabilization. The patient was discharged 10 days after admission and at 11 months after the procedure she had mild symptons without drug therapy and echocardiographic signs of mild residual mitral stenosis (mitral valve area: 2,0cm²).

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