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ABSTRACT The effects of diets containing oilseeds were measured to evaluate the productive and economic parameters in the finishing of young, feedlot Nellore bulls. Twenty-four young Nellore bulls were used, with an initial body weight (BW) of 311.46±0.37 kg and 24 months of age, distributed into individual stalls ( 4 × 20 m) in a completely randomized design, totaling four treatments with six repetitions per treatment. Four diets (control, based on corn and soybean meal, and three diets containing cottonseed, soybean, and sunflower) were evaluated. Feed and orts were measured daily to calculate intake and costs. The dry matter intake of the control group was higher than soybean (10.64 kg/day), cotton (9.88 kg/day), and sunflower (9.30 kg/day) treatments, respectively. The cottonseed treatment showed the highest average neutral detergent fiber intake. There was a dietary effect of diets on average daily gain, total weight gain, and final weight. The soybean treatment showed the highest performance, total gain (232.55 kg), and final weight (544.38 kg). Oilseed intake can modify the fatty acids profile in the meat, decreasing its saturated fatty acid content. Whole soybean seed favors performance, improves feed efficiency, fatty acid profile, and fat distribution in the carcass, and can reduce production costs.

https://doi.org/10.37496/rbz5220220160

Agronomic performance of cowpea cultivars inoculated with rhizobia in the brazilian semiarid region
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Oliveira, Pedro R. H. de

; Lopes, Welder de A. R.

; Silveira, Flávio P. da M.

; Santos, Manoel G. dos

; Santos, Gisele L. dos

; Silva, Silvana F. da

; Silveira, Lindomar M. da

; Barros Júnior, Aurélio P.

Revista Caatinga

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2023, Volume 36 N. 4 Pages 785 - 793

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT This work aimed to evaluate the agronomic efficiency of cowpea cultivars inoculated with rhizobia strains recommended for cowpea in a semiarid environment. Experiments were carried out in Mossoró, Rio Grande do Norte, in two agricultural cycles: the first from January to April 2019, and the second from June to August of the same year. The experimental design adopted was randomized blocks with four replications arranged in a 4 × 4 x 2 factorial scheme, with treatments consisting of four cowpea cultivars: ‘BRS Imponente’, ‘BRS Itaim’, ‘BRS Novaera’, and ‘BRS Tumucumaque’ as well as three sources of N, two strains of Bradyrhizobium spp. registered for cowpea (BR 3262 and BR 3267) and, the application of mineral N (50 kg ha-1), beyond an absolute control, without inoculation or application of mineral N. In addition to two planting seasons. The cultivar ‘BRS Tumucumaque’ showed greater productive potential. The inoculation of cowpea seeds with Bradyrhizobium strains BR 3262 and BR 3267 provided grain yields similar to those obtained with the application of mineral N.

RESUMO Este trabalho teve como objetivo avaliar a eficiência agronômica de cultivares de feijão-caupi inoculadas com linhagens de rizóbios recomendadas para feijão-caupi em ambiente semiárido. Os experimentos foram conduzidos em Mossoró, Rio Grande do Norte, em duas safras agrícolas: o primeiro de janeiro a abril de 2019, e o segundo de junho a agosto do mesmo ano. O delineamento experimental adotado foi de blocos ao acaso com quatro repetições em esquema fatorial 4 × 4 x 2, com tratamentos constituídos por quatro cultivares de feijão-caupi: 'BRS Imponente', 'BRS Itaim', 'BRS Novaera' e 'BRS Tumucumaque' e três fontes de N, duas linhagens de Bradyrhizobium spp. registradas para o feijão-caupi (BR 3262 e BR 3267), aplicação de N mineral (50 kg ha-1), além de uma testemunha absoluta, sem inoculação ou aplicação de N mineral. Além de duas épocas de plantio. A cultivar 'BRS Tumucumaque' apresentou maior potencial produtivo. A inoculação de sementes de feijão-caupi com as linhagens de Bradyrhizobium BR 3262 e BR 3267 proporcionou rendimentos de grãos semelhantes aos obtidos com a aplicação de N mineral.

https://doi.org/10.1590/1983-21252023v36n406rc

Avaliação da Energética Prevista nos Modelos Regionais BRAMS, ETA e WRF: Parte I - Inverno
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Gan, Manoel A.

; Ferreira, Sérgio H.S.

; Piva, Everson D.

; Rozante, José R.

; Garcia, José R.M.

; Fernandes, Alex A.

; Neves, André L.O.

; Silva, Vinícios M.

Revista Brasileira de Meteorologia

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dec 2021, Volume 36 N. 4 Pages 775 - 803

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo é avaliar os termos da equação da tendência da energia cinética do distúrbio (K’) nas previsões de 24 h e 48 h dos modelos regionais BRAMS, WRF e ETA. Estes modelos foram integrados operacionalmente no Centro de Previsão de Tempo e Estudos Climáticos (CPTEC). O período de avaliação foi de 1 de junho a 31 de agosto de 2016, sendo que o domínio utilizado foi a região da América do Sul. A resolução horizontal dos modelos é de 5 km e a temporal é de 6 horas. As condições iniciais e de contorno foram obtidas do Global Forecast System (GFS) do National Centers for Environmental Prediction (NCEP), com resolução horizontal de 0,25°. Os modelos foram inicializados apenas com a análise das 1200 UTC. Os modelos foram integrados com a versão não-hidrostática, sendo que o WRF utilizou a parametrização cumulus de Kain-Frisch, o ETA a parametrização culumus de Betts-Miller e o BRAMS Grell e Freitas. Em geral, os três modelos subestimam K’ nas latitudes médias, principalmente sobre os oceanos, porém o ETA é o que menos subestima e o WRF o que tem o maior viés negativo. Com relação aos termos de conversão baroclínica e barotrópica, além do termo de convergência do fluxo ageostrófico, os três modelos apresentam um padrão semelhante aos das análises numéricas do GFS.

Abstract The aim of this study is to evaluate the terms of the eddy kinetic energy (K’) equation in the 24 h and 48 h forecasts of the regional models BRAMS, WRF and ETA. These models were operationally integrated at the Weather Forecast and Climate Studies Center (CPTEC). The evaluation period was from June 1 to August 31, 2016 and the domain was the region of South America. The horizontal resolution of the three models is 5 km and the temporal is 6 h. The initial and boundary conditions were obtained from the Global Forecast System (GFS) of the National Centers for Environmental Prediction (NCEP), with a horizontal resolution of 0.25°. The models were initialized only with the analysis of 1200 UTC. The non-hydrostatic version of the three models was run, with WRF using Kain-Frisch cumulus parameterization, ETA Betts-Miller culumus parameterization and BRAMS Grell and Freitas. In general, the three models underestimate K‘ in mid-latitudes, mainly over the oceans, however, ETA is the one that underestimates the least and WRF the most. Regarding the terms of baroclinic and barotropic conversion, in addition to the term of ageostrophic flow convergence, the three models have a similar pattern of these three terms with that of GFS numerical analysis.

https://doi.org/10.1590/0102-77863640042

Talinumpaniculatum: a plant with antifungal potential mitigates fluconazole-induced oxidative damage-mediated growth inhibition of Candida albicans
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Cerdeira, Cláudio Daniel

; Silva, Jeferson J. da

; Netto, Manoel F. R.

; Boriollo, Marcelo F. G.

; Moraes, Gabriel O. I.

; Santos, Gérsika B.

; dos Reis, Luis F. C.

; Brigagão, Maísa R. P. L.

Revista Colombiana de Ciencias Químico - Farmacéuticas

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aug 2020, Volume 49 N. 2 Pages 401 - 431

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Objetivos: este estudio investigó la bioactividad del extracto de hoja en bruto (EHB) y las fracciones hexano (HX) y acetato de etilo (AcOEt) de Talinum paniculatum solo y en asociación con fluconazol (FLC) contra cepas de referencia y aislados clínicos de Candida albicans resistente a FLC. Además, evaluó la capacidad antioxidante, la composición química de esta planta y los mecanismos subyacentes del efecto fungicida. Métodos: la actividad antifúngica se evaluó mediante microdilución en caldo para establecer las concentraciones inhibitorias mínimas (CIM) y microbicidas mínimas (CMM). Durante el tratamiento con FLC y productos vegetales se detectó la generación de especies reactivas de oxígeno (ERO) (radicales hidroxilo [HO●]) en células de C. albicans utilizando las sondas fluorescentes permeables a la membrana APF y HPF. El perfil de cromatografía líquida de alta resolución (CLAR), el análisis cuantitativo de compuestos antioxidantes y el ensayo DPPH fueron evaluados. Resultados: el EHB y las fracciones presentaron una excelente actividad antifúngica y selectividad contra las células de C. albicans, pero no tuvieron efectos sinérgicos con FLC. Los valores de CIM para EHB y sus fracciones contra la cepa referencia de C. albicans fueron del orden de: HX (31,25 μg ml-1) < AcOEt (62,5 μg ml-1) < EHB (500 μg ml-1), y contra C. albicans resistente a FLC: HX (125 μg ml-1)= AcOEt < EHB (500 µg ml-1). EHB y sus fracciones fueron más potentes antifúngicos que FLC contra los aislados clínicos. Además, estos productos vegetales tienen efectos fungicidas contra C. albicans resistentes a FLC, esto conirmó el potencial antifúngico. Por el contrario, durante la asociación se demostró que los productos vegetales causan un aumento en la CIM de FLC de 2 a 16 veces. La exposición a FLC aumentó los niveles de ERO (HO●) en las células de C. albicans. Los aumentos en las CIM de FLC se debieron a la acción de los antioxidantes presentes en EHB y sus fracciones para prevenir la inhibición del crecimiento mediada por ERO inducida por FLC en C. albicans. Conclusión: T. paniculatum puede ser una fuente de compuestos bioactivos con potencial antifúngico. Sin embargo, debido al uso común de su hoja comestible, se recomienda usarla con precaución durante la terapia con FLC (ya que puede disminuir la susceptibilidad a FLC).

SUMMARY Aims: This study investigated the bioactivity of the crude leaf extract (CLE) and fractions hexane (HX) and ethyl acetate (EtOAc) from Talinum paniculatum alone and in association with fluconazole (FLC) against reference strain and clinical isolates of FLC-resistant Candida albicans. Furthermore, the antioxidant capability, chemical composition of this plant, and the effect's underlying mechanisms were evaluated. Methods: The antifungal activity was evaluated using checkerboard assay to establish the minimum inhibitory (MIC) and minimum microbicidal concen trations (MMC). During FLC and plant products challenges, the reactive oxygen species (ROS) generation (hydroxyl radicals [HO●]) were detected in C. albicans cells using the membrane-permeable fluorescent probes APF and HPF. High-performance liquid chromatography (HPLC) profile, quantitative analysis of antioxidant compounds, and free radical scavenging activity (DPPH assay) tests were performed. Results: The CLE and fractions presented outstanding antifungal activity and selectivity against C. albicans cells but had no synergistic effect’s with FLC. The MIC values for CLE and its fractions against C. albicans reference strain were in the order of HX (31.25 µg ml-1) < EtOAc (62.5 μg ml-1) < CLE (500 μg ml-1), and against FLC-resistant C. albicans HX (125 μg ml-1) = EtOAc < CLE (500 μg ml-1). CLE and its fractions had more potent antifungal activities than FLC against the clinical isolates. Moreover, fungicidal effect’s for these plant products were demonstrated against FLC-resistant C. albicans, which further conirmed an antifungal potential. Conversely, during association, plant products were shown to cause an increase in FLC MIC anywhere from 2- to 16-fold. FLC exposure led to an increase in the steady-state levels of ROS (HO●) in C. albicans cells. Next, we found that the increases in FLC MICs were owing to action of antioxidants containing-CLE and its fractions in preventing FLC-induced ROS-mediated growth inhibition of C. albicans. Conclusion: T. paniculatum can be a source of bioactive compounds with antifungal potential. However, because of the common use of its edible leaf, caution is advised during therapy with FLC (since it can decrease FLC susceptibility).

https://doi.org/10.15446/rcciquifa.v49n2.89704 347 downloads

Talinum paniculatum leaves with in vitro antimicrobial activity against reference and clinical strains of Staphylococcus aureus interfere with oxacillin action
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Cerdeira, Cláudio Daniel

; da Silva, Jeferson J.

; Netto, Manoel F. R.

; Boriollo, Marcelo F. G.

; Santos, Gérsika B.

; dos Reis, Luis F. C.

; Brigagão, Maísa R. P. L.

Revista Colombiana de Ciencias Químico - Farmacéuticas

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aug 2020, Volume 49 N. 2 Pages 432 - 451

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN Propósito: evaluamos el potencial antibacteriano del extracto de hoja en bruto (EHB) y las fracciones hexano (HX) y acetato de etilo (AcOEt) de Talinum paniculatum solo y en asociación con oxacilina (OXA) contra Staphylococcus aureus resistente a OXA (ORSA, ambientales) y S. aureus sensible a OXA (OSSA, ATCC 25923). Además, se realizaron pruebas de toxicidad. Métodos: la actividad antibacteriana se evaluó mediante microdilución en caldo para establecer las concentraciones inhibitorias mínimas (CIM) y bactericidas mínimas (CBM). Se evaluó la toxicidad en ratones. Resultados: los valores de CIM para el EHB y sus fracciones contra ORSA y OSSA fueron del orden de HX (500 μg ml-1) = AcOEt < EHB (4000 μg ml-1). AcOEt y HX presentaron actividades antibacterianas sobresalientes contra ORSA, y estas fracciones fueron bactericidas hacia OSSA. Por el contrario, las asociaciones entre el producto vegetal (EHB, AcOEt o HX) y OXA no mostraron efectos sinérgicos. Durante estas asociaciones, hubo un aumento en las CIM de OXA de 2 a 4092 veces. EHB no mostró toxicidad a una dosis de 5 g kg-1. Conclusión: aunque T. paniculatum es una buena fuente de compuestos bioactivos con potencial antiestofilocócico, los investigadores deben ser cautelosos, ya que su hoja comestible puede interferir con la terapia con OXA (mitigando la inhibición del crecimiento inducida por OXA o la muerte de S. aureus y promoviendo resistencia bacteriana).

SUMMARY Propose: We evaluated the antibacterial potential of the crude leaf extract (CLE) and fractions hexane (HX) and ethyl acetate (EtOAc) from Talinum paniculatum alone and in association with oxacillin (OXA) against OXA-resistant Staphylococcus aureus (ORSA, environment isolates) and OXA-sensitive S. aureus (OSSA, ATCC 25923). Furthermore, toxicity tests were performed. Methods: The antibacterial activity was evaluated through checkerboard assay (broth microdilution) to establish the minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC). Toxicity test in mice was assessed. Results: The MIC values for the CLE and its fractions against ORSA and OSSA were in the order of HX (500 μg ml-1) = EtOAc < CLE (4000 μg ml-1). EtOAc and HX presented outstanding antibacterial activities against ORSA, and these fractions were bactericidal toward OSSA. Conversely, the associations between plant product (CLE, EtOAc, or HX) and OXA exhibited no synergistic effects. During these associations, there was an increase in OXA MICs anywhere from 2- to 4092-fold. The CLE presented absence of toxicity at a dose of 5 g kg-1 (in vivo). Conclusion: Although T. paniculatum be a good source of bioactive compounds with antistaphylococcal potential, the researchers should be cautious, since its edible leaf may interfere with OXA therapy (mitigating OXA-induced growth inhibition or killing of S. aureus and enhancing S. aureus resistance).

https://doi.org/10.15446/rcciquifa.v49n2.89894 322 downloads

Medidas de distanciamento social no controle da pandemia de COVID-19: potenciais impactos e desafios no Brasil
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Aquino, Estela M. L.

; Silveira, Ismael Henrique

; Pescarini, Julia Moreira

; Aquino, Rosana

; Souza-Filho, Jaime Almeida de

; Rocha, Aline dos Santos

; Ferreira, Andrea

; Victor, Audêncio

; Teixeira, Camila

; Machado, Daiane Borges

; Paixão, Enny

; Alves, Flávia Jôse Oliveira

; Pilecco, Flávia

; Menezes, Greice

; Gabrielli, Ligia

; Leite, Luciana

; Almeida, Maria da Conceição Chagas de

; Ortelan, Naiá

; Fernandes, Qeren Hapuk R. Ferreira

; Ortiz, Renzo Joel Flores

; Palmeira, Raquel Nunes

; Pinto Junior, Elzo Pereira

; Aragão, Erika

; Souza, Luis Eugenio Portela Fernandes de

; Barral Netto, Manoel

; Teixeira, Maria Glória

; Barreto, Mauricio Lima

; Ichihara, Maria Yury

; Lima, Raíza Tourinho dos Reis Silva

Ciência & Saúde Coletiva

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jun 2020, Volume 25 Suppl. 1 Pages 2423 - 2446

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A pandemia de COVID-19 tem desafiado pesquisadores e gestores a encontrar medidas de saúde pública que evitem o colapso dos sistemas de saúde e reduzam os óbitos. Esta revisão narrativa buscou sistematizar as evidências sobre o impacto das medidas de distanciamento social na epidemia de COVID-19 e discutir sua implementação no Brasil. Foram triados artigos sobre o efeito do distanciamento social na COVID-19 no PubMed, medRXiv e bioRvix, e analisados atos do poder público nos níveis federal e estadual para sumarizar as estratégias implementadas no Brasil. Os achados sugerem que o distanciamento social adotado por população é efetivo, especialmente quando combinado ao isolamento de casos e à quarentena dos contatos. Recomenda-se a implementação de medidas de distanciamento social e de políticas de proteção social para garantir a sustentabilidade dessas medidas. Para o controle da COVID-19 no Brasil, é imprescindível que essas medidas estejam aliadas ao fortalecimento do sistema de vigilância nos três níveis do SUS, que inclui a avaliação e uso de indicadores adicionais para monitorar a evolução da pandemia e o efeito das medidas de controle, a ampliação da capacidade de testagem, e divulgação ampla e transparente das notificações e de testagem desagregadas.

Abstract The COVID-19 pandemic has challenged researchers and policy makers to identify public safety measures forpreventing the collapse of healthcare systems and reducingdeaths. This narrative review summarizes the available evidence on the impact of social distancing measures on the epidemic and discusses the implementation of these measures in Brazil. Articles on the effect of social distancing on COVID-19 were selected from the PubMed, medRXiv and bioRvix databases. Federal and state legislation was analyzed to summarize the strategies implemented in Brazil. Social distancing measures adopted by the population appear effective, particularly when implemented in conjunction with the isolation of cases and quarantining of contacts. Therefore, social distancing measures, and social protection policies to guarantee the sustainability of these measures, should be implemented. To control COVID-19 in Brazil, it is also crucial that epidemiological monitoring is strengthened at all three levels of the Brazilian National Health System (SUS). This includes evaluating and usingsupplementary indicators to monitor the progression of the pandemic and the effect of the control measures, increasing testing capacity, and making disaggregated notificationsand testing resultstransparentand broadly available.

https://doi.org/10.1590/1413-81232020256.1.10502020 73073 downloads

200.000 IU of vitamin D does not reduce resting Blood Pressure and Inhibit Post-Exercise Hypotension in elderly women: a pilot study
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GONÇALVES, MARIA DA CONCEIÇÃO R.

; MIRANDA NETO, MANOEL

; CAVALCANTE, ISA G.M.

; SEBADELHE, VITTÓRIA R.R.J.

; SOUZA, MICHELE F. De

; NEVES, JULIANA P.R.

; SOUZA, FLAVIA T.L. DE

; TAVARES, RENATA L.

; COSTA, MATHEUS S.

; SILVA, ALEXANDRE S.

Anais da Academia Brasileira de Ciências

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2020, Volume 92 N. 1 elocation e20190227

Abstract: En | Text: En | PDF: En

Abstract Given the scarcity of studies with elderly and the existence of studies investigating the effect of vitamin D supplementation in PEH (post exercise hypotension), this study evaluated the effect of a single megadose of vitamin D on resting blood pressure (RBP) and post-exercise hypotension (PEH) in the elderly. 11 hypertensive elderly women (70.3 ± 1.7 years) received a single megadose of 200.000 IU of cholecalciferol or a placebo, orally, through capsules. On day 7, the subjects performed 30 minutes of aerobic exercise with blood pressure measurement before exercise and every 10 minutes after exercise during 60 minutes, besides cardiac autonomic modulation. RBP did not significantly change. Exercise promoted significant systolic PEH only in one moment post exercise in treated group and in the placebo group promoted significant systolic PEH at four moments. Significant diastolic PEH did not occur in any of the groups. Sympathovagal activity increased at post exercise balance in supplemented subjects at 20 min, 40 min, 50 min and 60 min when compared to rest; this increase was not observed in the placebo. A megadose of vitamin D did not reduce RBP, promoted partial inhibition of systolic PEH and increased sympathovagal balance.

https://doi.org/10.1590/0001-3765202020190227 1055 downloads

Medidas de distanciamento social no controle da pandemia de COVID-19: potenciais impactos e desafios no Brasil
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Aquino, Estela M. L.

; Silveira, Ismael Henrique

; Pescarini, Julia Moreira

; Aquino, Rosana

; Souza-Filho, Jaime Almeida de

; Rocha, Aline dos Santos

; Ferreira, Andrea

; Victor, Audêncio

; Teixeira, Camila

; Machado, Daiane Borges

; Paixão, Enny

; Alves, Flávia Jôse Oliveira

; Pilecco, Flávia

; Menezes, Greice

; Gabrielli, Ligia

; Leite, Luciana

; Almeida, Maria da Conceição Chagas de

; Ortelan, Naiá

; Fernandes, Qeren Hapuk R. Ferreira

; Ortiz, Renzo Joel Flores

; Palmeira, Raquel Nunes

; Pinto Junior, Elzo Pereira

; Aragão, Erika

; Souza, Luis Eugenio Portela Fernandes de

; Barral Netto, Manoel

; Teixeira, Maria Glória

; Barreto, Mauricio Lima

; Ichihara, Maria Yury

; Lima, Raíza Tourinho dos Reis Silva

Ciência & Saúde Coletiva

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2020, Volume 25 Suppl. 1 Pages 2423 - 2446

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232020256.1.10502020

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vilar, Lucio

; Abucham, Julio

; Albuquerque, José Luciano

; Araujo, Luiz Antônio

; Azevedo, Monalisa F.

; Boguszewski, Cesar Luiz

; Casulari, Luiz Augusto

; Cunha Neto, Malebranche B. C.

; Czepielewski, Mauro A.

; Duarte, Felipe H. G.

; Faria, Manuel dos S.

; Gadelha, Monica R.

; Garmes, Heraldo M.

; Glezer, Andrea

; Gurgel, Maria Helane

; Jallad, Raquel S.

; Martins, Manoel

; Miranda, Paulo A. C.

; Montenegro, Renan M.

; Musolino, Nina R. C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Silva, Cíntia M. S.

; Viecceli, Camila

; Bronstein, Marcello D.

Archives of Endocrinology and Metabolism

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mar 2018, Volume 62 N. 2 Pages 236 - 263

Abstract: En | Text: En | PDF: En

ABSTRACT Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience.

https://doi.org/10.20945/2359-3997000000032 36158 downloads

10.

NEW SEMISYNTHETIC DERIVATIVES OF A BENZYLISOTHIOCYANATE ISOLATED FROM Moringa oleifera AND EVALUATION OF THEIR CYTOTOXIC ACTIVITY
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Almeida, Diana Kelly C. de

; Silva, Marcos R. da

; Oliveira, Maria Conceição F. de

; Mafezoli, Jair

; Mattos, Marcos C. de

; Moura, Andréa F.

; Moraes Filho, Manoel O.

; Barbosa, Francisco G.

Química Nova

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oct 2017, Volume 40 N. 10 Pages 1186 - 1190

Abstract: En | Text: En | PDF: En

From the natural product 4-(4'-O-acetyl-α-L-rhamnosyloxy)benzylisothiocyanate (1), isolated from the flowers of Moringa oleifera Lam (Moringaceae), four new semisynthetic derivatives, N-[4-(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]-2-(pyridinil-4-carbonil)hydrazine-1-carbothioamide (3), 4-(4'-O-acetyl-2',3'-dimesyloxy-α-L-rhamnosyloxy)benzylisothiocyanate (4), N-[(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]hydrazinecarbothioamide (5), 4-[4'-O-acetyl-2',3'-O-bis(decanoiloxy)-α-L-rhamnosyloxy]benzylisothiocianate (6), and the known compound 4-(2',3',4'-O-triacetyl-α-L-rhamnosyloxy)benzylisothiocyanate (2), were obtained. All compounds were tested for their cytotoxicity against the tumor cell lines SF-295, HL-60, HCT-116 e PC-3. The natural product 1 and the semisynthetic derivatives 2 and 4 were the most active compounds (IC50 from16.0 to 3.7 µmol L-1) against all tumor cell lines.

https://doi.org/10.21577/0100-4042.20170132 888 downloads

11.

Expressão do mRNA para IGF-2 em oócitos e células do cumulus extraídos de folículos antrais e pré-antrais de ovelhas nativas do Estado de Pernambuco
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Melo, Arthur N.

; Santos Júnior, Edivaldo R.

; Silva, Diogo F.

; Adrião, Manoel

; Porto, Ana L.F.

; Wischral, Aurea

Pesquisa Veterinária Brasileira

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may 2017, Volume 37 N. 5 Pages 526 - 530

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivou-se avaliar a expressão do mRNA para o gene do fator de crescimento IGF-2 em oócitos e células do cumulus de ovelhas em diferentes estágios do desenvolvimento folicular. Os folículos classificados morfologicamente como antrais (terciários e pré-ovulatórios) foram aspirados manualmente para obtenção dos oócitos e células do cumulus. Os folículos pré-antrais (secundários) foram extraídos do córtex ovariano, por microdissecção, e os oócitos retirados. Nos dois grupos, os oócitos foram desnudados e agrupados em “pools” de dez células cada (Grupo A, n=10; Grupo B, n=10) e dez amostras com grupos de células do cumulus (Grupo A1, n=10, B1, n=10). O mRNA foi extraído e convertido em cDNA utilizando a técnica da RT-PCR, utilizando Oligo DT randômico para o mRNA. A análise da expressão confirmou a expressão gênica para IGF-2 nos grupos de oócitos e células do cumulus. Houve um aumento da expressão relativa do mRNA para IGF-2 nos grupos de oócitos durante a fase mais tardia do desenvolvimento folicular e as diferenças foram consideradas significantes (p<0,05). Não houve variação significante da expressão de IGF2 entre os grupos de células do cumulus. Conclui-se que o fator de crescimento IGF-2 tem níveis mais elevados de expressão em oócitos ovinos, na segunda fase do desenvolvimento folicular, mas expressão semelhante em células do cumulus durante as fases estudadas do desenvolvimento folicular.

ABSTRACT: The aim of this study was to analyze the mRNA expression of IGF-2 growth factor in oocytes and cumulus cells from native sheep follicles at different stages of follicular development. The classified morphologically as antral follicles (tertiary preovulatory) were aspirated manually to obtain the oocyte and the cumulus cells. The preantral follicles (secondary) were extracted from the ovarian cortex by microdissection, and oocytes were removed. In both groups, oocytes were denuded and grouped into “pools” of ten cells each (Group A, n=10, Group B, n=10) and ten samples with groups of cumulus cells (Group A1, n=10; B1, n=10). The mRNA was extracted and converted to cDNA using the RT-PCR technique. The expression analysis confirmed the expression of IGF-2 gene for groups of oocyte and the cumulus cells. There was an increase in the relative expression of mRNA for IGF-2 for groups of oocytes during the later stage of follicular development and differences were considered significant (p<0.05). There was no significant variation in the expression of IGF2 between groups of cumulus cells. It is concluded that the growth factor IGF-2 has higher levels of expression in sheep oocytes in the second stage of follicular development in the conditions adopted and similar expression in cumulus cells during various stages of follicular development.

https://doi.org/10.1590/s0100-736x2017000500017 906 downloads

12.

Effect of racial crossing on the scrotum-testicular biometry in sheep submitted to scrotal insulation
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Lisboa-Neto, Antônio F.S.

; Mariano-Filho, Paulo G.

; Carvalho, Jean R.

; Araújo, Morgana S.

; Santos, Amilton C.

; Machado, Felicianna C.F.

; Silva-Filho, Manoel L.

; Machado-Júnior, Antônio A.N.

Pesquisa Veterinária Brasileira

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mar 2017, Volume 37 N. 3 Pages 291 - 294

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivou-se neste trabalho avaliar o efeito do cruzamento sobre as características biométricas escroto-testiculares de carneiros da raça Santa Inês e mestiços (Santa Inês x Dorper), submetidos à insulação escrotal, acompanhando o retorno dessas características aos valores previamente observados. Para isso, foram realizadas duas mensurações referentes à circunferência escrotal (CE), comprimento (C) e largura testicular (L), antes da insulação. O volume testicular (V) foi calculado pela fórmula V=2 [(r2) x π x h]. As bolsas de insulação foram fixadas ao redor do funículo espermático e escroto com fita adesiva e esparadrapo, permanecendo por sete dias. Após o período de insulação, as mensurações foram realizadas a cada sete dias, totalizando 15 mensurações durante todo o experimento. Os dados obtidos foram submetidos à análise de variância (ANOVA) para um delineamento em blocos casualizados, com dois blocos, 15 tratamentos e quatro repetições. As variáveis analisadas foram submetidas ao teste de Dunnett a 5% de probabilidade, para comparar os valores obtidos antes e após a insulação. Para a comparação entre as raças, as variáveis foram submetidas ao teste de Tukey a 5% de probabilidade. Todos os animais estudados sofreram influência significativa (P<0,05) após a insulação escrotal, porém os carneiros da raça Santa Inês retornaram aos valores anteriormente observados em um espaço de tempo mais curto do que os mestiços. Conclui-se que carneiros da raça Santa Inês apresentam maior resistência do que animais mestiços quando submetidos ao estresse térmico induzido pela insulação escrotal.

ABSTRACT: The objective of this study was to evaluate the effect of the racial crossing on scrotum-testicular biometric characteristics of four sheep Santa Ines and four crossbred (Santa Ines x Dorper) submitted to scrotal insulation, following the return of these characteristics to values previously reported. For this, two measurements were made regarding the scrotal circumference (SC), length (L) and testicular width (W) before treatments. The testicular volume (V) was calculated by the formula V=2 [(r2) x π x H]. The pouches were made with double-layer plastic, internally lined with cotton, and fixed around the spermatic funiculus and scrotum with adhesive tape and bandage remaining in this position for seven days. Measurements were made every seven days, totaling 15 measurements throughout the experiment. The data were submitted to analysis of variance (ANOVA) to a randomized block design with two blocks, 15 treatments and four replications. The variables analyzed were subjected to Dunnett test at 5% probability, to compare the values obtained before and after insulation. For comparison between the breeds, the variables were submitted to Tukey test at 5% probability. All animals studied suffered significant influence (P<0.05) after scrotal insulation, but Santa Ines returned to the values previously observed in a shorter period than the crossbred. In summary, sheep Santa Ines have a higher resistance than crossbred animals when subjected to thermal stress induced by scrotal insulation.

https://doi.org/10.1590/s0100-736x2017000300014 677 downloads

13.

Amblyseius largoensis in controlling red palm mite under semi-field conditions
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Morais, Elisangela Gomes Fidelis

; Oliveira, Jéssica Silva

; Gondim Jr., Manoel Guedes Corrêa

; Moraes, Gilberto José

Pesquisa Agropecuária Brasileira

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may 2016, Volume 51 N. 5 Pages 671 - 675

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar a eficiência de duas populações de Amblyseius largoensis (Acari: Phytoseiidae) no controle de Raoiella indica (Acari: Tenuipalpidae). Os tratamentos foram: liberação de A. largoensis da ilha de La Réunion; liberação de A. largoensis do Estado de Roraima; e controle, sem liberação de predadores. Inicialmente, 20 predadores foram liberados por planta; outras três liberações de dez adultos por planta foram feitas aos 46, 135 e 156 dias após a primeira liberação. A densidade populacional foi estimada a cada 20 dias, durante seis meses. Ambas as populações de A. largoensis avaliadas não são suficientemente eficientes para controlar a população de R. indica.

Abstract: The objective of this work was to evaluate the efficiency of two Amblyseius largoensis (Acari: Phytoseiidae) populations in controlling Raoiella indica (Acari: Tenuipalpidae). The treatments were: release of A. largoensis from the island of La Réunion; release of A. largoensis from the state of Roraima, Brazil; and a control, without predator release. Initially, 20 predators were released per plant; three other releases were done at a rate of ten adults per plant, at 46, 135, and 156 days after the first release. The population densities were estimated every 20 days, during six months. Both A. largoensis populations evaluated are not sufficiently efficient to control the R. indica population.

https://doi.org/10.1590/S0100-204X2016000500030 1245 downloads

14.

Conformational Variability in Sulfonamide Chalcone Hybrids: Crystal Structure and Cytotoxicity
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Castro, Mirian R. C. de

; Aragão, Ângelo Q.

; Silva, Cameron C. da

; Perez, Caridad N.

; Queiroz, Darlene P. K.

; Queiroz Júnior, Luiz Henrique K.

; Barreto, Stefânio

; Moraes, Manoel O. de

; Martins, Felipe Terra

Journal of the Brazilian Chemical Society

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may 2016, Volume 27 N. 5 Pages 884 - 898

Abstract: En | Text: En | PDF: En

Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. They were synthesized by Claisen-Schmidt condensation reaction between N-(4-acetylphenyl)benzenesulfonamide or N-(4-acetylphenyl)-2,5-dichlorobenzenesulfonamide with benzaldehyde or p-nitrobenzaldehyde. Values of Z' > 1 are found in three compounds as a consequence of conformerism. The chalcone molecular backbones are featured by different levels of planarity in their conformers. Another conformational variability is in its benzenesulfonamide moiety. In the compound came from N-(4-acetylphenyl)benzenesulfonamide and benzaldehyde, there is a rotation of ca. 180° on the bond axis bridging the sulfonamide and chalcone motifs of one conformer if the two others are taken as references. The cytotoxic activity of all compounds synthesized here and of two other related sulfonamide chalcones was also assessed against three cancer cell lines (SF-295, HCT-8 and MDA-MB-435). The para-nitro compounds were the most active ones among all those tested, regardless of substitution pattern in benzenesulfonamide core.

https://doi.org/10.5935/0103-5053.20150341 1555 downloads

15.

Qualidade de vida nas espondiloartrites: análise de uma grande coorte brasileira
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Ribeiro, Sandra L.E.

; Albuquerque, Elisa N.

; Bortoluzzo, Adriana B.

; Gonçalves, Célio R.

; Silva, José Antonio Braga da

; Ximenes, Antonio Carlos

; Bértolo, Manoel B.

; Keiserman, Mauro

; Menin, Rita

; Skare, Thelma L.

; Carneiro, Sueli

; Azevedo, Valderílio F.

; Vieira, Walber P.

; Bianchi, Washington A.

; Bonfiglioli, Rubens

; Campanholo, Cristiano

; Carvalho, Hellen M.S.

; Costa, Izaias P.

; Duarte, Angela L.B. Pinto

; Kohem, Charles L.

; Leite, Nocy H.

; Lima, Sonia A.L.

; Meirelles, Eduardo S.

; Pereira, Ivânio A.

; Pinheiro, Marcelo M.

; Polito, Elizandra

; Resende, Gustavo G.

; Rocha, Francisco Airton C.

; Santiago, Mittermayer B.

; Sauma, Maria de Fátima L.C.

; Valim, Valéria

; Sampaio-Barros, Percival D.

Revista Brasileira de Reumatologia

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feb 2016, Volume 56 N. 1 Pages 22 - 27

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Analisar as variáveis demográficas e clínicas associadas à diminuição da qualidade de vida em uma grande coorte brasileira de pacientes com espondiloartrite (EpA). Métodos: Foi aplicado um protocolo de pesquisa único a 1.465 pacientes brasileiros classificados como tendo EpA de acordo com os critérios do European Spondyloarthropaties Study Group (ESSG), atendidos em 29 centros de referência em reumatologia do Brasil. Foram registradas as variáveis clínicas e demográficas. A qualidade de vida foi analisada por meio do questionário Ankylosing Spondylitis Quality of Life (ASQoL). Resultados: A pontuação média do ASQoL foi de 7,74 (+ 5,39). Ao analisar doenças específicas no grupo de EpA, as pontuações do ASQoL não apresentaram diferença estatisticamente significativa. Os dados demográficos mostraram piores escores de ASQoL associados ao gênero feminino (p = 0,014) e etnia negra (p < 0,001). Quanto aos sintomas clínicos, a dor na região glútea (p = 0,032), a dor cervical (p < 0,001) e a dor no quadril (p = 0,001), estiveram estatisticamente associadas a piores escores no ASQoL. O uso contínuo de fármacos anti-inflamatórios não esteroides (p < 0,001) e agentes biológicos (p = 0,044) esteve associado a escores mais elevados de ASQoL, enquanto outros medicamentos não interferiram nos escores do ASQoL. Conclusão: Nesta grande série de pacientes com EpA, o sexo feminino e a etnia negra, bem como sintomas predominantemente axiais, estiveram associados a uma qualidade de vida reduzida.

Abstract Objective: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). Methods: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: The mean ASQoL score was 7.74 (± 5.39). When analyzing the specific diseases in the SpA group, the ASQoL scores did not present statistical significance. Demographic data showed worse scores of ASQoL associated with female gender (p = 0.014) and African-Brazilian ethnicity (p < 0.001). Regarding clinical symptoms, buttock pain (p = 0.032), cervical pain (p < 0.001) and hip pain (p = 0.001), were statistically associated with worse scores of ASQoL. Continuous use of nonsteroidal anti-inflammatory drugs (p < 0.001) and biologic agents (p = 0.044) were associated with higher scores of ASQoL, while the other medications did not interfere with the ASQoL scores. Conclusion: In this large series of patients with SpA, female gender and African-Brazilian ethnicity, as well as predominant axial symptoms, were associated with impaired quality of life.

https://doi.org/10.1016/j.rbr.2015.03.003 3358 downloads

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