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ABSTRACT Light is essential for providing energy for photosynthetic reactions and has a complex and not yet fully understood effect on heliconia growth and yield. Thus, the objective of this study was to evaluate the effect of light intensity on the growth and photosynthesis of heliconia under semi-arid conditions and to screen potential genotypes tolerant to high solar irradiation levels during the vegetative stage. The experiment was conducted in Petrolina, PE, Brazil, whose geographic coordinates are 09° 19’ 14” S, 40° 32’ 40” W, with an average altitude of 387 m. The experimental design used was in randomized blocks, arranged in a split-plot scheme, and the treatments were composed of two light intensities (full sun and 50% shading) and five genotypes (Heliconia psittacorum x H. spathocircinata cv. Golden Torch; H. psittacorum cv. Red Opal; H. bihai cv. Lobster Claw Two; H. rauliniana and H. rostrata). Growth and gas exchange assessments were conducted on the 100th day after the trial initiation. Light intensity (full sun and 50% shading) did not influence the rates of photosynthesis (A), stomatal conductance (gs), or transpiration (E) of plants. However, the isolated effect of the genotype revealed that plants of cv. Red Opal, H. bihai, H. rauliniana, and cv. Golden Torch had higher values of A, gs, and E. Overall, shading improved plant growth. We conclude that the genotypes H. psittacorum cv. Red Opal, and H. psittacorum cv. Golden Torch exhibited the greatest tolerances to high solar irradiance conditions.

RESUMO A luz é essencial por fornecer energia para as reações fotossintéticas e tem uma influência complexa e não totalmente compreendida no crescimento e produção de helicônias. Assim, objetivou-se avaliar o efeito da intensidade de luz sobre o crescimento e fotossíntese de helicônias em condições semiáridas e a triagem de genótipos potenciais tolerantes as condições de altos níveis de irradiação solar durante o estágio vegetativo. O experimento foi conduzido em Petrolina-PE, Brasil, cujas coordenadas geográficas são: 09° 19’ 14” S, 40° 32’ 40” O, com altitude média de 387 m. O delineamento experimental utilizado foi em blocos casualizados, arranjados em esquema de parcelas subdivididas, e os tratamentos foram compostos por duas intensidades de luz (pleno sol e sombreamento de 50%) e cinco genótipos (Heliconia psittacorum x H. spathocircinata cv. Golden Torch; H. psittacorum cv. Red Opal; H. bihai cv. Lobster Claw Two; H. rauliniana e H. rostrata). No 100° dia após o início do experimento foram realizadas avaliações de crescimento e trocas gasosas. As intensidades de luz (pleno sol e sombreamento 50%) não influenciaram a taxa fotossintética (A), condutância estomática (gs) e transpiração (E) das plantas. Porém, o efeito isolado do genótipo revela que plantas de cv. Red Opal, H. bihai, H. rauliniana e cv. Golden Torch apresentaram maiores valores de A, gs e E. Em geral, o sombreamento favoreceu maior incremento no crescimento das plantas. Conclui-se que os genótipos H. psittacorum cv. Red Opal e H. psittacorum cv. Golden Torch exibem maior tolerância às condições de elevada irradiância solar.

https://doi.org/10.1590/1807-1929/agriambi.v27n10p757-763

Agronomic characteristics and quality of lettuce cultivars in different crop seasons in western Alagoas, Brazil
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Pereira, Dalbert de F.

; Silva, Thiago P. da

; Freire, Winandy. A.

; Souza, Ênio G. F.

; Cruz, Ellen A. da

; Feitosa, Regilane M.

Revista Caatinga

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mar 2023, Volume 36 N. 1 Pages 106 - 114

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Growing lettuce under high temperatures and light incidence, as in the Alagoas State hinterland, Brazil, induces early tasseling and decreases the quality of the product. Thus, the objective of this work was to evaluate the production and post-harvest quality of lettuce cultivars in different crop seasons in western Alagoas, Brazil. A randomized block experimental design was used, with four replications. The treatments consisted of lettuce cultivars: Baba-de-Verão, Cinderela, Elba, Mônica, Solaris, and Veneranda. The winter crop was more favorable for plant diameter, except for Baba-de-Verão, whose performance was similar in both seasons and stood out in the summer. The winter crop resulted in better performance in plant height, stem diameter, and fresh matter yield, whereas summer plants reached larger number of leaves. The cultivar Mônica presented longer stem length, denoting lower tolerance to early tasseling and, therefore, it is not indicated to be grown in the region. The cultivar Baba-de-Verão (Lisa group) reached higher fresh matter yield, number of leaves per plant, and stem diameter, and it was the most adequate cultivar to be grown in western Alagoas. Elba, Solaris, and Veneranda were the lettuce cultivars from the Crespa group that stood out. Baba-de-Verão was the cultivar that presented the best performance for chlorophyll a, b, and total. The cultivar Solaris presented the highest carotenoid contents. Plants grown in the winter reached higher chlorophyll a and total, carotenoid contents, pH, and soluble solid (SS) to titratable acidity (TA) ratio, whereas the lettuce grown in the summer had higher SS and TA.

RESUMO A alface, quando produzida em altas temperaturas e elevada luminosidade, como as encontradas no Sertão Alagoano, é induzida ao pendoamento precoce e à baixa qualidade. Em função disso, o objetivo foi avaliar a produção e a qualidade pós-colheita de cultivares de alface em função de épocas de cultivo distintas no oeste do Estado de Alagoas. O delineamento experimental foi em blocos ao acaso, com quatro repetições, sendo os tratamentos referentes às cultivares Babá-de-Verão, Cinderela, Elba, Mônica, Solaris e Veneranda. Para diâmetro de planta, o cultivo de inverno foi mais favorável, com exceção da Babá-de-Verão que manteve o desempenho semelhante nas duas épocas e destaque da cultivar no verão. O cultivo de inverno proporcionou melhor desempenho de altura de planta, diâmetro de caule e produtividade de massa verde, enquanto no verão as plantas atingiram maior número de folhas. A cultivar Mônica obteve maior comprimento do caule, indicando menor tolerância ao pendoamento precoce, não sendo indicada para o cultivo na região. A Babá-de-Verão (lisa) atingiu maior produtividade de massa verde, número de folhas por planta e diâmetro de caule, sendo a cultivar mais adequada para o cultivo no oeste de Alagoas. Dentre as crespas, destacaram-se as cultivares Elba, Solaris e Veneranda. A cultivar que apresentou melhor desempenho para clorofilas a, b e totais foi a Babá-de-Verão. A Solaris obteve maior teor de carotenoides. As plantas de inverno alcançaram maiores clorofilas a e totais, carotenoides, pH e relação sólidos solúveis totais (SS) e acidez total titulável (TA), enquanto a alface de verão obteve maior SS e TA.

https://doi.org/10.1590/1983-21252023v36n112rc

Plant extracts in the control of plant pathogens seeds and fusariosis in okra
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Silva, Mônica Shirley Brasil dos Santos e

; Rodrigues, Antônia Alice Costa

; Oliveira, Anna Christina Sanazário de

; Silva, Erlen Keila Cândido e

; Dias, Larisse Raquel Carvalho

; Costa, Natalia de Jesus Ferreira

; Silva, Mônica Shirley Brasil dos Santos e

; Rodrigues, Antônia Alice Costa

; Oliveira, Anna Christina Sanazário de

; Silva, Erlen Keila Cândido e

; Dias, Larisse Raquel Carvalho

; Costa, Natalia de Jesus Ferreira

Revista Ceres

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mar 2023, Volume 70 N. 2 Pages 124 - 131

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this study was to assess seed health and the effect of plant extracts on Fusarium oxysporum f. sp. vasinfectum mycelial growth and sporulation, plant pathogen reduction in seeds and fusariosis control in okra seedlings. Health was assessed by the Blotter Test, after immersing the seeds in natural extracts and plating. To verify the mycelial growth of the plant pathogen, the extracts were incorporated in PDA culture medium and the pathogen was added and assessed, including the spore count. In the greenhouse, the seeds were immersed in the extracts, sown and at 15 days they were sprayed with extracts, at 21 days inoculated with the pathogen and disease severity on the seedlings was assessed 7 days later. There were higher incidences of Fusarium sp. and Rhizopus stolonifer in the seeds of the cultivars Valença and Santa Cruz 47. The extracts that resulted in lower pathogen incidence was basil, in cv. Valença and cinnamon and neem, in cv. Santa Cruz 47. The neem treatment presented the best inhibition percentage and the lowest sporulation mean in mycelial growth of the pathogen. Neem presented higher disease incidence control in the seedlings of cv. Valença and basil on the seedlings of cv. Santa Cruz 47.

https://doi.org/10.1590/0034-737x202370020014

UM NOVO COMPOSTO DE COORDENAÇÃO DINUCLEAR PROJETADO PARA NÃO APRESENTAR DANOS OXIDATIVOS E EFEITOS TOXICOLÓGICOS
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Silva, Jamerson H. F. da

; Galembeck, André

; Belian, Mônica F.

; Silva, Wagner E.

; Santos, Jandyson M.

; Silva Neto, Jacinto da Costa

; Aguiar, Jaciana S.

; Gonçalves, Teresinha

Química Nova

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2023, Volume 46 N. 5 Pages 425 - 434

Abstract: Pt | Text: Pt | PDF: Pt

The synthesis, characterization, acute toxicity, antitumor activity, and histopathological analysis of a novel dinuclear platinum(2+) complex - [Pt(DACH-κ2N)µ-(C4H2O6-κ4O)Pt(DACH-κ2N)] - is reported. Through acute toxicity tests, it was possible to place the platinum complexes into categories according to the OECD protocol. The dinuclear complex was classified in category 2 (cisplatin - category 1; and oxaliplatin - category 2). Analyzing the interaction between dsDNA and dinuclear complex was observed an Tm increase, suggesting that the dinuclear complex-dsDNA interact probably through of the interstrand form. Evaluations of tumor masses extracted from mice inoculated with Ehrlich carcinoma demonstrated a percent of tumor inhibition similar for cisplatin and oxaliplatin, but statistically different and superior for the case of the dinuclear complex. Cisplatin and oxaliplatin showed 41.4 and 40.8% inhibition, respectively, while the dinuclear complex presented 66.3%. The histopathological analysis demonstrated that the group treated with cisplatin showed more significant tissue damage, moderate hepatic steatosis, and nephritis. The livers, spleens, and kidneys of the animals treated with the dinuclear complex were within the normality range with no tissue lesions, and absence of metastasis.

https://doi.org/10.21577/0100-4042.20230032

Effect of the Addition of Porcelain Tile Polishing Residue in Ceramic Masses for Sanitary Ware
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Silva, Ricardo H. L.

; Neves, Gelmires A.

; Nóbrega, Ana C. V.

; Farias, Rosiane M. C.

; Rocha, Mônica F. B.

; Alves, Kleber G. B.

; Menezes, Romualdo R.

Materials Research

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2023, Volume 26 Suppl. 1 elocation e20230563

Abstract: En | Text: En | PDF: En

Currently, there is a severe shortage of good-quality feldspar deposits. On the other hand, porcelain tile polishing residue has been widely recognized as an alternative raw material for the ceramic industry. Thus, this research evaluated the effect of the partial replacement of feldspar by the porcelain polishing residue (PPR) in formulations for sanitary stoneware. It was replaced from 2% to 20% of the total mass of feldspar by the residue. The raw materials were characterized by X-ray fluorescence, X-ray diffraction, and particle size determination. Then, they were mixed in a wet ball mill, and the rheological properties of the suspensions were analyzed. Samples of the test were produced by slip casting and sintered at 1160 °C, 1180 °C, and 1200 °C. Rheological characteristics were not affected when up to 20% of feldspar was replaced by residue. Bodies with high amounts of PPR had flexural strength and water absorption values similar to those of bodies without PPR in formulations. Furthermore, apparent porosity values lower than the reference mass were obtained with the addition of 6% of the residue in the formulation.

https://doi.org/10.1590/1980-5373-mr-2022-0563

Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered to 1,2,3-1H-Triazoles Against the Planktonic Growth of Streptococcus mutans
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Gomes, Mônica P.

; Correia, Eduardo M.

; Gomes, Max W. L.

; Santos, Claudio C. C. dos

; Barros, Caroline S.

; Abreu, Fernanda V. de

; Antunes, Leonardo S.

; Ferreira, Vitor F.

; Gonçalves, Mariana C.

; Resende, Gabriel O. de

; Gonzaga, Daniel T. G.

; Pinto, Carla E. C.

; Paixão, Izabel C. N. P.

; Silva, Fernando C. da

Journal of the Brazilian Chemical Society

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sep 2022, Volume 33 N. 9 Pages 1028 - 1040

Abstract: En | Text: En | PDF: En

The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the S. mutans in vitro and the acute toxicity of the better ones in vivo. We observed strong inhibition results in the disc diffusion test ranging, the halos of inhibitions, from 18.66 (± 0.57) to 29 (± 2.64) mm, and good values in the minimum inhibitory concentration (5 to 50 μg), for the compounds 9e, 9h, 9i and 9j: Furthermore, they do not have a cytotoxic effect at the concentrations tested. Besides that, in the in vivo test, they show some slight alteration in the histopathological analyses and the biochemistry. Thus, we found four potential candidates to become instruments for the treatment of cavities.

https://doi.org/10.21577/0103-5053.20220014

ESTUDO DA ATIVIDADE ANTITUMORAL DE UM NOVO COMPLEXO DE RU3+: UMA PROPOSTA PARA O DESIGN DE METALOFÁRMACOS DE BAIXA TOXICIDADE
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Andrade, Maria Helena P. S. de

; Aguiar, Jaciana S.

; Silva, Teresinha G. da

; Santos, Jandyson M.

; Silva, Wagner E.

; Belian, Mônica F.

Química Nova

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aug 2022, Volume 45 N. 8 Pages 906 - 912

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

In this article the synthesis, characterization, acute toxicity, and antitumor activity of the novel Ru3+ complex are described. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol guideline 423. The cisplatin complex was classified in category 1 and the sodium diaquodimalonateruthenate(3+) - Na[Ru(H2O)2(Mal-κ2O)2] - was classified in category 4. This result demonstrates the lower toxicity achieved by the ruthenium complex in comparison with metallopharmaceuticals compound. Evaluations of tumor masses extracted from mice inoculated with Ehrlich ascites carcinoma demonstrated percent inhibition lowest to cisplatin. Cisplatin showed 58% inhibition (1 mg/kg), while Na[Ru(H2O)2(Mal-κ2O)2] complex (5 mg/kg) presented 77%.

https://doi.org/10.21577/0100-4042.20170886

UMA ROTA ALTERNATIVA PARA OBTENÇÃO DE REDES DE COORDENAÇÃO VIA SÍNTESE SOLVOTERMAL UTILIZANDO Eu2O3 E ÁCIDO 2,6-NAFTALENODICARBOXÍLICO
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Oliveira, Roberta F.

; Pereira, Raphael H. de M.

; Viana, Rodrigo da Silva

; Alves Júnior, Severino

; Belian, Mônica F.

Química Nova

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may 2022, Volume 45 N. 5 Pages 537 - 542

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

An alternative route to synthesis of metal-organic frameworks containing Eu(III) ion was proposed via solvothermal process in aqueous medium. The compounds of the minimal formulae [Ln2(NDC)3(H2O)4] were synthesized starting from the mixture of the 2,6-naphthalenedicarboxylic acid with europium(III) oxide. So far, this type of metalorganic framework based on the lanthanide ion synthetic route has not been investigated before as the main metal sources are nitrate and chloride salts. The structural characterizations were performed by FTIR spectroscopy, thermal analysis TG-DSC, and X-ray diffraction. The results of IR and TG were consistent with the structural determination results and complemented by X-ray diffraction patterns. SEM images also corroborate the morphologies found in recent research on this material. The materials obtained shown high-intensity luminescence, for the Eu-NDC compound, which corroborates with an energy transfer efficient of the ligand to Eu(III) ion.

https://doi.org/10.21577/0100-4042.20170863

Memory elicitation, T-cell response and antibody production: an independent study of an inactivated entire virus vaccine (Coronavac)
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SOUZA-SILVA, GUILHERME ANTONIO DE

; AQUINO, RODRIGO CESAR A. DE

; SOUSA, GEORON F. DE

; BARROS, BÁRBARA RAFAELA S.

; LIMA, MARÍLLIA RAPHAELLA C.F. DE

; CRUZ, LEONARDO C.O.

; MARCOS, BIANCA F. SÃO

; SILVA, ANNA JÉSSICA D.

; TALES, APARECIDA VIRGÍNIA S.

; DINIZ, MADI V.

; LIMA, MÔNICA MARIA C.

; SÁ, IGOR W.A. DE

; RODRIGUES, FÁBIO AUGUSTO C.

; SOUZA, EDSON B. DE

; NASCIMENTO, ARIONE V. DO

; VIEIRA, AMANDA M.

; CARVALHO, BRUNO M. DE

; CAMPELO JÚNIOR, EVÔNIO B.

; FREITAS, ANTONIO CARLOS DE

; MELO, CRISTIANE M.L. DE

Anais da Academia Brasileira de Ciências

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2022, Volume 94 N. 3 elocation e20211590

Abstract: En | Text: En | PDF: En

Abstract Health professionals working to mitigate the COVID-19 pandemic are one of the main risk groups for the disease, being prioritized for vaccination. Considering this, the aim of this study was to analyze the immune response of these professionals immunized with CoronaVac in the first and second doses. Blood samples were collected after the first and second doses of the vaccine (CoronaVac) and used to investigate hematological and biochemical parameters, analysis of immunoglobulin production, cytokines, and gene expression profile, as well as the identification of subsets of immune cells. Post-first dose immunological phenotypic memory (CD27+) profiles (T CD4+, TCD8+ and CD19+) showed a significant increase, as did Monocyte APCs (CD80+HLA-DR+) in relation to the second dose. The cytokines IL-2, IL-6 and IFN-° showed increased values in relation to the other analyzed cytokines. The Th2/Th17 profile in the second dose was characterized by gene expression analysis. The production of IgM and IgG after vaccination showed statistically significant values in the comparison between doses. CoronaVac showed activation of APCs monocytes, memory response of T and B lymphocytes, with immunoglobulins production. This set of responses is characterized by the Th2/Th17 immunological profile.

https://doi.org/10.1590/0001-3765202220211590

10.

Diretriz de Miocardites da Sociedade Brasileira de Cardiologia – 2022
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Montera, Marcelo Westerlund

; Marcondes-Braga, Fabiana G.

; Simões, Marcus Vinícius

; Moura, Lídia Ana Zytynski

; Fernandes, Fabio

; Mangine, Sandrigo

; Oliveira Júnior, Amarino Carvalho de

; Souza, Aurea Lucia Alves de Azevedo Grippa de

; Ianni, Bárbara Maria

; Rochitte, Carlos Eduardo

; Mesquita, Claudio Tinoco

; de Azevedo Filho, Clerio F.

; Freitas, Dhayn Cassi de Almeida

; Melo, Dirceu Thiago Pessoa de

; Bocchi, Edimar Alcides

; Horowitz, Estela Suzana Kleiman

; Mesquita, Evandro Tinoco

; Oliveira, Guilherme H.

; Villacorta, Humberto

; Rossi Neto, João Manoel

; Barbosa, João Marcos Bemfica

; Figueiredo Neto, José Albuquerque de

; Luiz, Louise Freire

; Hajjar, Ludhmila Abrahão

; Beck-da-Silva, Luis

; Campos, Luiz Antonio de Almeida

; Danzmann, Luiz Cláudio

; Bittencourt, Marcelo Imbroinise

; Garcia, Marcelo Iorio

; Avila, Monica Samuel

; Clausell, Nadine Oliveira

; Oliveira Jr, Nilson Araujo de

; Silvestre, Odilson Marcos

; Souza, Olga Ferreira de

; Mourilhe-Rocha, Ricardo

; Kalil Filho, Roberto

; Al-Kindi, Sadeer G.

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Ferreira, Silvia Moreira Ayub

; Rizk, Stéphanie Itala

; Mattos, Tiago Azevedo Costa

; Barzilai, Vitor

; Martins, Wolney de Andrade

; Schultheiss, Heinz-Peter

Arquivos Brasileiros de Cardiologia

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2022, Volume 119 N. 1 Pages 143 - 211

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220412

11.

Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.

; Moura, Lídia Ana Zytynski

; Issa, Victor Sarli

; Vieira, Jefferson Luis

; Rohde, Luis Eduardo

; Simões, Marcus Vinícius

; Fernandes-Silva, Miguel Morita

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Albuquerque, Denilson Campos de

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Rossi Neto, João Manoel

; Danzmann, Luiz Claudio

; Montera, Marcelo Westerlund

; Oliveira Junior, Mucio Tavares de

; Clausell, Nadine

; Silvestre, Odilson Marcos

; Bestetti, Reinaldo Bulgarelli

; Bernadez-Pereira, Sabrina

; Freitas Jr, Aguinaldo F.

; Biolo, Andréia

; Barretto, Antonio Carlos Pereira

; Jorge, Antônio José Lagoeiro

; Biselli, Bruno

; Montenegro, Carlos Eduardo Lucena

; Santos Júnior, Edval Gomes dos

; Figueiredo, Estêvão Lanna

; Fernandes, Fábio

; Silveira, Fabio Serra

; Atik, Fernando Antibas

; Brito, Flávio de Souza

; Souza, Germano Emílio Conceição

; Ribeiro, Gustavo Calado de Aguiar

; Villacorta, Humberto

; Souza Neto, João David de

; Goldraich, Livia Adams

; Beck-da-Silva, Luís

; Canesin, Manoel Fernandes

; Bittencourt, Marcelo Imbroinise

; Bonatto, Marcely Gimenes

; Moreira, Maria da Consolação Vieira

; Avila, Mônica Samuel

; Coelho Filho, Otavio Rizzi

; Schwartzmann, Pedro Vellosa

; Mourilhe-Rocha, Ricardo

; Mangini, Sandrigo

; Ferreira, Silvia Moreira Ayub

; Figueiredo Neto, José Albuquerque de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1174 - 1212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210367 3168 downloads

12.

A DYNAMIC JOB SHOP MODEL FOR SCHEDULING TASKS IN A SOFTWARE DEVELOPMENT ENVIRONMENT
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Ribeiro, Sildenir A.

; Schmitz, Eber A.

; Silva, Mônica F. da

; de Alencar, Antônio Juarez S. M.

JISTEM - Journal of Information Systems and Technology Management

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2021, Volume 18 elocation e202118001

Abstract: En | Text: En | PDF: En

ABSTRACT This work proposes a Dynamic Job Shop Scheduling (DJSS) model for scheduling the task in a software production environment. The aim is to organize the insertion of tasks in the shop in a precedence order previously defined that obeys the mapping of the critical path and the critical chain to identify constraints in the productive process. The complexity and dynamism of the software development environment require a mature and adjusted process that enables management throughout its extension. Therefore, the Unified Process (UP) was used in conjunction with the Theory of Constraints (TOC) in the Software Development Process (SDP). The UP requires an efficient model for the processing of activities, given by the set of independent variables involved in the process. For this reason, a model to programming the task based on dynamic scheduling was developed. The problem around the DJSS is to program the tasks in the shop in a way that allows identifying one or more production lines in the shop with constraints of capacity at runtime. A capacity constraint is any element that disturbs the productive process, causing L={Mi Aj} to have delivery (DA) of less than 100% of the artifacts, given by the set of jobs (jn) scheduled. The resource with capacity constraint limits the production of the machines in the production line, leading to bottlenecks in the production process. A bottleneck, in turn, is denoted by the production limitation of a machine (people) caused by one or more capacity constraints that imply maximum production, which in this case is defined by D={Mi, Aj=100%}. In this work, the maximum production is given by the set of tasks processed in each of the phases of the UP and according to the productive calendar, which delimits the deadline of each delivery and establishes the budget of hours for the shop. The set of tasks scheduled and "rescheduling" and properly processed in all phases define the total production of each machine. The use of DJSS facilitated the organization and management of insertion and rescheduling operations in the shop and as result, produced data to measure the effort/time that allowed identifying the bottleneck of the software production process.

https://doi.org/10.4301/s1807-1775202118001 41 downloads

13.

Diagnostic performance between histopathological and molecular methods in the detection of Helicobacter pylori
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Silva, Lucas Luiz L.

; Calassa, Igor M. C.

; Oliveira, Ana Karoline S.

; Ramos, Amanda F. P. L.

; Pontes, Jaqueline C.

; Cardoso, Daniela M. M.

; Rasmussem, Lucas T.

; Carneiro, Lilian Carla

; Barbosa, Monica S.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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2021, Volume 57 elocation e2832021

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: Helicobacter pylori (H. pylori) é uma bactéria Gram negativa considerada o agente etiológico de várias doenças gástricas. A prevalência da infecção bacteriana varia de acordo com idade, localização geográfica, etnia e status socioeconômico. A infecção crônica ocasionada por esse microrganismo pode favorecer o desenvolvimento de patologias severas, como o adenocarcinoma gástrico. Nesse sentido, o diagnóstico precoce é essencial para um melhor prognóstico e o sucesso terapêutico. Vários métodos de diagnóstico realizados com técnicas invasivas e não invasivas, com diferentes sensibilidade e especificidade, têm sido utilizados na detecção de H. pylori. Objetivo: Comparar o desempenho das técnicas molecular e histopatológica utilizadas no diagnóstico da infecção por H. pylori. Métodos: Setenta e seis amostras de tecido gástrico foram coletadas de pacientes dispépticos e submetidas ao diagnóstico molecular e histopatológico. A detecção molecular foi realizada utilizando o gene ribossomal (rRNA 16S) por meio da técnica de reação em cadeia da polimerase (PCR). Resultados: O método molecular de diagnóstico com base na PCR detectou a bactéria em 63,1% das amostras, enquanto o teste histopatológico identificou o microrganismo em apenas 38,1% das biópsias gástricas. Os dados demonstram que a técnica de PCR apresentou cerca de 1,6 vezes mais sensibilidade que a técnica histopatológica. Conclusão: A técnica de PCR foi o método de diagnóstico mais eficiente para detecção de H. pylori e pode ser implementada na rotina laboratorial como teste complementar para detecção precoce de H. pylori.

ABSTRACT Introduction: Helicobacter pylori (H. pylori) is a Gram negative bacterium considered to be the etiologic agent of various gastric diseases. The prevalence of bacterial infection varies according to age, geographic location, ethnicity and socioeconomic status. The chronic infection caused by microorganism can favor the development of severe pathologies such as gastric adenocarcinoma. In this sense, early diagnosis is essential for a better prognosis and therapeutic success. Several diagnostic methods performed using invasive and non-invasive techniques, with different sensitivity and specificity, have been used in the detection of H. pylori. Objective: To compare the performance of the molecular and histopathological technique used in the diagnosis of H. pylori infection. Methods: 76 gastric tissue samples were collected from dyspeptic patients who underwent molecular and histopathological diagnosis. Molecular detection was performed using the ribosomal gene (16S rRNA) using the polymerase chain reaction (PCR) technique. Results: The PCR-based molecular diagnostic method detected the bacterium in 63.1% of the samples, while the histopathological test identified the microorganism in only 38.1% of gastric biopsies. The data demonstrated that the PCR technique was about 1.6 times more sensitive than the histopathological technique. Conclusion: The PCR technique was the most efficient diagnostic method for detecting H. pylori and can be implemented in the laboratory routine as a complementary test for the early detection of H. pylori.

RESUMEN Introducción: Helicobacter pylori (H. pylori) es una bacteria Gram negativa considerada agente etiológico de diversas enfermedades gástricas. La prevalencia de la infección bacteriana varía según la edad, la ubicación geográfica, la etnia y el nivel socioeconómico. La infección crónica provocada por esos microorganismos puede favorecer el desarrollo de patologías graves como el adenocarcinoma gástrico. Por esa razón, el diagnóstico precoz es fundamental para un mejor pronóstico y éxito terapéutico. En la detección de H. pylori se han utilizado varios métodos de diagnóstico realizados mediante técnicas invasivas y no invasivas, con diferentes sensibilidad y especificidad. Objetivo: Comparar el desempeño de las técnicas moleculares e histopatológicas utilizadas en el diagnóstico de la infección por H. pylori. Métodos: Se recolectaron 76 muestras de tejido gástrico de pacientes dispépticos y se las sometieron a diagnóstico molecular e histopatológico. La detección molecular se realizó mediante el gen ribosómico (ARNr 16S) mediante la técnica de reacción en cadena de la polimerasa (PCR). Resultados: El método molecular de diagnóstico basado en PCR detectó la bacteria en el 63,1% de las muestras, mientras que la prueba histopatológica identificó el microorganismo en solo el 38,1% de las biopsias gástricas. Los datos demostraron que la técnica de PCR era aproximadamente 1,6 veces más sensible que la técnica histopatológica. Conclusión: La técnica de PCR fue el método diagnóstico más eficaz para la detección de H. pylori y puede implementarse en la rutina del laboratorio como prueba complementaria para la detección precoz de H. pylori.

https://doi.org/10.5935/1676-2444.20210037 1 downloads

14.

Toxocariasis and Toxocara vaccine: a review
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Jaramillo-Hernández, Dumar A.

; Salazar-Garcés, Luis F.

; Baquero-Parra, Mónica M.

; da Silva-Pinheiro, Carina

; Alcántara-Neves, Neuza M.

ORINOQUIA

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dec 2020, Volume 24 N. 2 Pages 79 - 95

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Según la prevalencia y el impacto en la salud pública, la toxocariasis es una zoonosis subestimada en los países en desarrollo y desarrollados. La transmisión de Toxocara spp. involucra animales de compañía caninos y felinos, como también perros y gatos sin hogar (Canis familiaris y Felis catus, respectivamente), que diseminan los huevos del parásito en sus heces al medio ambiente. Uno de los principales factores de riesgo para la infección y el desarrollo de la toxocariasis humana es convivir con cachorros felinos y caninos. Durante mucho tiempo, la estrategia preventiva para esta infección parasitaria ha sido el uso regular de medicamentos antiparasitarios para reducir la carga parasitaria a corto plazo. Se puede lograr una protección inmunológica duradera con la vacunación, sin embargo, todavía no se dispone de una vacuna. Por lo tanto, es fundamental conocer y comprender el estado del arte del desarrollo de vacunas para el control efectivo de esta zoonosis. Este artículo revisa los estudios experimentales centrados en el desarrollo de vacunas para el control de la toxocariasis, y se presta especial atención a los estudios epidemiológicos relevantes sobre la importancia de los caninos domésticos en la toxocariasis humana.

Abstract Based on prevalence and impact on public health, toxocariasis is an underestimated zoonosis in developing and developed countries. The transmission of Toxocara spp. involves pets, stray dogs and cats (Canis familiaris and Felis catus, respectively), which spread the parasite’s eggs in their feces to the environment. One of the main risk factors for the infection and development of human toxocariasis, is to cohabit with puppies and kittens. For a long time, the preventive strategy for this parasitic infection has been the regular use of antiparasitic drugs to reduce parasite burden in the short term. A long lasting immunological protection can be achieved with vaccination, however, a vaccine is not yet available. Therefore, it is fundamental to know and to understand the state of the art of vaccine development for effective control of this zoonosis. This paper reviews the experimental studies focused on vaccine development for toxocariasis control, and special attention is given to relevant epidemiological studies on the importance of dogs in human toxocariasis.

Resumo Com base na prevalência e no impacto na saúde pública, a toxocaríase é uma zoonose subestimada nos países em desenvolvimento e desenvolvidos. A transmissão de Toxocara spp. envolve animais cães e gatos de estimação e vadios (Canis familiaris e Felis catus, respectivamente), que espalham os ovos do parasita nas fezes para o meio ambiente. Um dos principais fatores de risco para a infecção e desenvolvimento da toxocaríase humana é coabitar com filhotes de cachorros e gatos. Por um longo tempo, a estratégia preventiva para essa infecção parasitária tem sido o uso regular de medicamentos antiparasitários para reduzir a carga parasitária a curto prazo. Uma proteção imunológica duradoura pode ser alcançada com a vacinação, no entanto, uma vacina ainda não está disponível. Portanto, é fundamental conhecer e entender o estado da arte do desenvolvimento de vacinas para o controle efetivo dessa zoonose. Este artigo revisa os estudos experimentais focados no desenvolvimento de vacinas para o controle da toxocaríase, e atenção especial é dada a estudos epidemiológicos relevantes sobre a importância dos cães na toxocaríase humana.

https://doi.org/10.22579/20112629.631 266 downloads

15.

COMPLEXOS DE PLATINA(II) CONJUGADO E ANÁLOGO A O-GLICOSÍDEOS: SÍNTESE, CARACTERIZAÇÃO ESTRUTURAL E ATIVIDADE ANTITUMORAL
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Lima, Lidiane M. A. de

; Santos, Mirelly D. F.

; Albuquerque, Leonardo S.

; Belian, Mônica F.

; Silva, Wagner E.

; R. F. Filho, João

; Santos, Jandyson M.

; Aguiar, Jaciana S.

; Silva, Teresinha G. da

Química Nova

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jun 2020, Volume 43 N. 6 Pages 752 - 759

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The synthesis, characterization, cytotoxicity and antitumor activity of platinum(II) complexes coordinated to O-glycoside and analogous is reported. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol. The cis-[PtCl2(C6H14S2O2)-κ2S] complex was classified in category 3 and the cis-[PtCl2(C26H38O12S2)-κ2S] complex was classified in category 4. This result demonstrates the lower toxicity achieved by the glycoside in comparison with its analogous system. Evaluations of tumor masses extracted from mice inoculated with Ehrlich carcinoma demonstrated percent inhibition similar to cisplatin and synthesized platinum complexes. Cisplatin showed 59% inhibition, while cis-[PtCl2(C6H14S2O2)-κ2S] and cis-[PtCl2(C26H38O12S2)-κ2S] complexes presented 57% and 59%, respectively. Although the glycosidic compounds exhibit tumor activity, reported in the literature, the presence of platinum ion was shown to be determinant for antitumor action according with the compounds tested, since the glycosidic ligand presented tumor inhibition of only 38%, with a similar antitumor activity in relation to cisplatin.

https://doi.org/10.21577/0100-4042.20170546 390 downloads

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