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au:SILVA, SANDRA REGINA MOTA
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1.
Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy
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Silva, Layla Alves Rodrigues da
; Santana, Renato Figueiredo
; Achar, Eduardo
; Ballester, Gerson
; Ortiz, Sandra Regina Mota
; Ribeiro Junior, Marcelo Augusto Fontenelle
.
ABSTRACT Purpose To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. Methods Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. Results To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. Conclusions The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.
https://doi.org/10.1590/acb360204
417 downloads
2.
Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
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Marques, Heloisa Helena de Sousa
; Pereira, Maria Fernanda Badue
; Santos, Angélica Carreira dos
; Fink, Thais Toledo
; Paula, Camila Sanson Yoshino de
; Litvinov, Nadia
; Schvartsman, Claudio
; Delgado, Artur Figueiredo
; Gibelli, Maria Augusta Bento Cicaroni
; Carvalho, Werther Brunow de
; Odone Filho, Vicente
; Tannuri, Uenis
; Carneiro-Sampaio, Magda
; Grisi, Sandra
; Duarte, Alberto José da Silva
; Antonangelo, Leila
; Francisco, Rossana Pucineli Vieira
; Okay, Thelma Suely
; Batisttella, Linamara Rizzo
; Carvalho, Carlos Roberto Ribeiro de
; Brentani, Alexandra Valéria Maria
; Silva, Clovis Artur
; Eisencraft, Adriana Pasmanik
; Rossi Junior, Alfio
; Fante, Alice Lima
; Cora, Aline Pivetta
; Reis, Amelia Gorete A. de Costa
; Ferrer, Ana Paula Scoleze
; Andrade, Anarella Penha Meirelles de
; Watanabe, Andreia
; Gonçalves, Angelina Maria Freire
; Waetge, Aurora Rosaria Pagliara
; Silva, Camila Altenfelder
; Ceneviva, Carina
; Lazari, Carolina dos Santos
; Abellan, Deipara Monteiro
; Santos, Emilly Henrique dos
; Sabino, Ester Cerdeira
; Bianchini, Fabíola Roberta Marim
; Alcantara, Flávio Ferraz de Paes
; Ramos, Gabriel Frizzo
; Leal, Gabriela Nunes
; Rodriguez, Isadora Souza
; Pinho, João Renato Rebello
; Carneiro, Jorge David Avaizoglou
; Paz, Jose Albino
; Ferreira, Juliana Carvalho
; Ferranti, Juliana Ferreira
; Ferreira, Juliana de Oliveira Achili
; Framil, Juliana Valéria de Souza
; Silva, Katia Regina da
; Kanunfre, Kelly Aparecida
; Bastos, Karina Lucio de Medeiros
; Galleti, Karine Vusberg
; Cristofani, Lilian Maria
; Suzuki, Lisa
; Campos, Lucia Maria Arruda
; Perondi, Maria Beatriz de Moliterno
; Diniz, Maria de Fatima Rodrigues
; Fonseca, Maria Fernanda Mota
; Cordon, Mariana Nutti de Almeida
; Pissolato, Mariana
; Peres, Marina Silva
; Garanito, Marlene Pereira
; Imamura, Marta
; Dorna, Mayra de Barros
; Luglio, Michele
; Rocha, Mussya Cisotto
; Aikawa, Nadia Emi
; Degaspare, Natalia Viu
; Sakita, Neusa Keico
; Udsen, Nicole Lee
; Scudeller, Paula Gobi
; Gaiolla, Paula Vieira de Vincenzi
; Severini, Rafael da Silva Giannasi
; Rodrigues, Regina Maria
; Toma, Ricardo Katsuya
; Paula, Ricardo Iunis Citrangulo de
; Palmeira, Patricia
; Forsait, Silvana
; Farhat, Sylvia Costa Lima
; Sakano, Tânia Miyuki Shimoda
; Koch, Vera Hermina Kalika
; Cobello Junior, Vilson
.
OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.
3.
Insect (Hexapoda) diversity in the oceanic archipelago of Fernando de Noronha, Brazil: updated taxonomic checklist and new records
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Rafael, José Albertino
; Limeira-de-Oliveira, Francisco
; Hutchings, Roger William
; Miranda, Gil Felipe Gonçalves
; Silva Neto, Alberto Moreira da
; Somavilla, Alexandre
; Camargo, Alexssandro
; Asenjo, Angélico
; Pinto, Ângelo Parise
; Bello, Ayr de Moura
; Dalmorra, Camila
; Mello-Patiu, Cátia Antunes de
; Carvalho, Claudio José Barros de
; Takiya, Daniela Maeda
; Parizotto, Daniele Regina
; Marques, Dayse Willkenia Almeida
; Cavalheiro, Denis de Oliveira
; Mendes, Diego Matheus de Mello
; Zeppelini, Douglas
; Carneiro, Eduardo
; Lima, Élison Fabrício Bezerra
; Lima, Estevam Cipriano Araújo de
; Godoi, Fabio Siqueira Pitaluga de
; Pessoa, Felipe Arley Costa
; Vaz-de-Mello, Fernando Zagury
; Sosa-Duque, Francisco José
; Flores, Heloísa Fernandes
; Fernandes, Itanna Oliveira
; Silva-Júnior, José Osvaldo
; Gomes, Lucas Roberto Pereira
; Monné, Marcela Laura
; Castro, Marcelo Cutrim Moreira de
; Silva, Marcelo Peixoto Gomes da
; Couri, Márcia Souto
; Gottschalk, Marco Silva
; Soares, Matheus Mickael Mota
; Monné, Miguel Angel
; Rafael, Miriam Silva
; Casagrande, Mirna Martins
; Mielke, Olaf Hermann Hendrik
; Grossi, Paschoal Coelho
; Pinto, Paula Jéssica Costa
; Bartholomay, Pedro Reck
; Sobral, Rafael
; Heleodoro, Raphael Aquino
; Machado, Renato José Pires
; Corrêa, Robson Crepes
; Hutchings, Rosa Sá Gomes
; Ale-Rocha, Rosaly
; Santos, Sandra Duque dos
; Lima, Sheila Pereira de
; Mahlmann, Thiago
; Silva, Vera Cristina
; Fernandes, Daniell Rodrigo Rodrigues
.
ABSTRACT Hexapods, commonly known as insects, are a neglected taxonomic group in the Fernando de Noronha archipelago, with unanswered questions about their species richness and the ecological processes in which they are involved (e.g., colonization, introduction, establishment, and extinction). Herein, we provide an updated Hexapod checklist with current nomenclatural combinations. The entomofauna of the Fernando de Noronha archipelago is currently composed of 453 species in 21 orders. The orders, and their respective number of species, are: Blattaria (9), Coleoptera (118), Collembola (29), Dermaptera (3), Diplura (1), Diptera (134), Embioptera (1), Hemiptera (29), Hymenoptera (59), Isoptera (2), Lepidoptera (25), Mantodea (1), Neuroptera (3), Odonata (5), Orthoptera (11), Phasmatodea (1), Phthiraptera (6), Psocoptera (3), Siphonaptera (1), Thysanoptera (10), and Zygentoma (2). The archipelago has 263 new taxon records (family + genera + species). Thirty-eight species (3.39%) were described from local specimens and most of them are likely endemic species. This study more than doubles our knowledge (from the previous 190 records) of the entomofauna in this large Brazilian archipelago. This study also provides a baseline for studies on its conservation status and for implementing future environmental management programs.
https://doi.org/10.1590/1806-9665-rbent-2020-0052
2462 downloads
4.
C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning
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Santana, Renato Figueiredo
; Silva, Layla Alves Rodrigues da
; Achar, Eduardo
; Ballester, Gerson
; Ribeiro Junior, Marcelo Augusto Fontenelle
; Ortiz, Sandra Regina Mota
.
Abstract Purpose Studies have demonstrated that star fruit consumption by nephropathic patients triggers severe neurotoxic effects that can lead to convulsions or even death. Brain areas likely susceptible to star fruit poisoning have not been investigated. The objective of the present study was to map possible epileptogenic areas susceptible to star fruit intoxication in nephropathic rats. Methods The study analyzed 25 rats (5 groups). Rats in the experimental group underwent bilateral ureteral obstruction surgery and orogastric gavages with star fruit juice. An electroencephalogram was used to confirm convulsive seizures. Urea and creatinine levels were used to confirm the uremia model. Immunohistochemical analysis was used to map cells with c-Fos protein (c-Fos+ cells) to identify brain areas with increased neuronal activity. Control groups included non-nephropathic and nephropathic rats that did not receive star fruit. Results A statistically significant increase (p<0.01) in c-Fos+ cells was noted in nephropathic animals receiving star fruit juice compared to control groups, in brain areas commonly related to epileptogenic neural circuits including the hippocampus, amygdala, rhinal cortex, anterior cingulate area, piriform area, and medial dorsal thalamus. Conclusion These data corroborate the neurotoxic capacity of star fruit in nephropathic patients.
https://doi.org/10.1590/s0102-865020200070000005
683 downloads
5.
URBAN AND ENVIRONMENTAL MANAGEMENT CHALLENGES CONSIDERING TRANSFORMATIONS IN PROPERTY LAW IN BRAZIL
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Resumo A hegemonia da propriedade privada no Brasil vem passando por transformações que têm relativizado seu caráter absoluto. Tanto pelo campo urbanístico, como ambiental, noções decorrentes das reflexões e práticas, espelhadas em um conjunto de marcos legais, têm trazido novos elementos para o debate que permeia a gestão territorial e ambiental. As contribuições trazidas pela Lei da Política Nacional do Meio Ambiente de 1981, pela Constituição Federal de 1988, pelo Estatuto da Cidade de 2001, entre outros regramentos normativos, produziram diferentes decorrências, inclusive no campo do direito individual privado, do direito coletivo e do direito difuso. A partir do fio condutor da legislação, busca-se discutir os conflitos e contradições presentes em diferentes modalidades do direito de propriedade e seus estreitos vínculos com a propriedade fundiária e imobiliária, com efeitos no universo das reflexões e das práticas do planejamento e da gestão territorial e ambiental.
Abstract Hegemony of private property in Brazil is undergoing transformations which have made its absolute nature relative. Both in the urban and environmental fields, notions arising from reflections and practices, and mirrored in a number of legal frameworks, have brought new ideas to debate, as well as land and environmental management practices. The contributions made by the National Environmental Policy Act of 1981, the Federal Constitution of 1988, the City Statute of 2001, among other normative regulations, have led to different consequences, including in the field of private individual rights, collective rights and diffuse rights. Based on the guiding principle behind legislation, we attempt to discuss the conflicts and contradictions found in different types of property rights and their close ties with land ownership and home ownership, affecting the universe of reflections and practices of planning, as well as land and environmental management.
Resumen La hegemonía de la propiedad privada en Brasil ha sido objeto de transformaciones que han relativizado su carácter absoluto. En el campo urbanístico como en el ambiental, nociones resultantes de reflexiones y prácticas, espejadas en marcos legales, han aportado nuevos elementos al debate sobre la gestión territorial y ambiental. Las contribuciones de la Ley de la Política de Medio Ambiente (1981), de la Constitución Federal (1988) y del Estatuto de la Ciudad (2001), entre otros reglamentos normativos, han generado diferentes consecuencias, incluso en el campo del derecho individual privado, del derecho colectivo y del derecho difuso. A partir del hilo conductor de la legislación, se ha buscado discutir los conflictos y las contradicciones presentes en diferentes formas del derecho de propiedad y sus estrechos enlaces con la propiedad inmobiliaria, con efectos en el universo de las reflexiones y de las prácticas de planeamiento y gestión territorial y ambiental.
https://doi.org/10.1590/1809-4422asoc212r2v2042017
5995 downloads
6.
IV Diretrizes Brasileiras de Hipertensão Arterial Grupos de trabalho
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Gomes, Marco Antonio Mota
; Pierin, Angela Maria Geraldo
; Sbissa, Antonio Silveira
; Nogueira, Armando da Rocha
; Brandão, Ayrton Pires
; Rodrigues, Cibeli I. Saad
; Mello, Edgar Pessoa de
; Mello Filho, José Xavier de
; Bodanese, Luiz Carlos
; Toscano, Paulo
; Ferreira Filho, Sebastião
; Nobre, Fernando
; Tavares, Agostinho
; Lopes, Antonio Carlos
; Ribeiro, Jorge Pinto
; Ayoub, José Carlos Aydar
; Ribeiro, José Márcio
; Introcaso, Luiz
; Corrêa, Marcelo
; Maranhão, Mario
; Jabur, Pedro
; Nascimento, Raimundo Marques
; Cunha, Roberto de Sá
; Mulinari, Rogério Andrade
; Machado, Carlos Alberto
; Avila, Adriana
; Andrade, Clóvis Oliveira
; Rocha, João Carlos
; Lopes, Margarida Maria Veríssimo
; Arruda, Maria Cecília G. Marinho
; Azevedo, Maria Fátima
; Carvalho, Maria Helena C.
; Lipp, Marilda Novaes
; Kohlmann, Nárcia Elisa B.
; Jesus, Neide de
; Jardim, Paulo César da Veiga
; Amodeo, Celso
; Negrão, Carlos Eduardo
; Ferreira, Celso
; Cunha, Cláudio Pereira da
; Toscano, Eli
; Lima, Eliuden Galvão de
; Monego, Estelamaris Tronco
; Braga, Fátima Lúcia Machado
; Chaves Jr., Hilton de Castro
; Heiman, Joel
; Carvalho, Tales de
; Kohlmann Jr., Osvaldo
; Avezum, Alvaro
; Ribeiro, Artur Beltrame
; Gomes, Carlos Alberto
; Giorgi, Dante Marcelo Artigas
; Feitosa, Gilson
; Ohashi, Harue
; Ramirez, José Antonio Franchini
; Machado, Marcelo Marcondes
; Salgado Filho, Natalino
; Luna, Rafael Leite
; Franco, Roberto Jorge da Silva
; Santos, Robson Augusto dos
; Oigman, Wille
; Pascoal, Istênio Fernandes
; Massaro, Airton
; Atallah, Álvaro Nagib
; Brandão, Andréa
; Freitas, Elizabete Viana de
; Cordovil, Ivan
; Oliveira, José Egídio Paulo de
; Ramos, José Geraldo L.
; Zanella, Maria Teresa
; Wajngarten, Maurício
; Miranda, Roberto Dischinger
; Kahhale, Soubihe
; Koch, Vera
; Mion Jr., Décio
; Guimarães, Armênio C.
; Palmeira, Catia Sueli
; Forjaz, Claudia Lucia de Moraes
; Coelho, Eduardo B.
; Almeida, Fernando Antonio
; Pellizari, Isabel Cristina Estefano
; Ribeiro, Marcos Ausenka
; Batlouni, Michel
; Lotufo, Paulo
; Capelari, Regina Teresa
; Magalhães, Lucélia C.
; Afiune Neto, Abrahão
; Cury, Abrão
; Moreira, Alci
; Souza, Ana Luisa de
; Fuchs, Flavio Danni
; Lessa, Ines
; Malachias, Marcus V. Bolívar
; Bezerra, Romero
; Fuchs, Sandra
; Praxedes, José Nery
; Cambara, Antonio
; Lucon, Antonio Marmo
; Mendonça, Berenice
; Borelli, Flavio
; Silva, Helio B.
; Romão Jr., João Egidio
; Carvalho, José Gastão Rocha
; Santello, José Luiz
; Bortolotto, Luiz
; Matavelli, Luis Celso
; Pinheiro, Maria Eliete
; Guimarães, Valéria
.
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