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Abstract Objective: To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Methods: Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results: 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion: The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.

https://doi.org/10.1016/j.jped.2022.07.007

How many species of Mollusca are there in Brazil? A collective taxonomic effort to reveal this still unknown diversity
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Machado, Fabrizio M.

; Miranda, Marcel S.

; Salvador, Rodrigo B.

; Pimenta, Alexandre D.

; Côrtes, Mariana O.

; Gomes, Jaime A.J.

; Miyahira, Igor C.

; Agudo-Padrón, Ignacio

; Oliveira, Cléo D.C.

; Caetano, Carlos H.S.

; Coelho, Paulo R.S.

; D’Ávila, Sthefane

; Arruda, Eliane P. de

; Almeida, Sérgio M. de

; Gomes, Suzete R.

; Alvim, Juliana

; Galvão-Filho, Hilton

; L. Ferreira-Júnior, Augusto

; Marques, Rodrigo C.

; Martins, Inês

; Souza, Leonardo S. de

; Arruda, Janine O.

; Cavallari, Daniel C.

; Santos, Sonia B. dos

; Pedro, Natan C.

; Salles, Anna C. de A.

; Dornellas, Ana P.S.

; Lima, Tarcilla C. de

; Amaral, Vanessa S. do

; Silva, Fernanda S.

; Passos, Flávio D.

; Thiengo, Silvana S.

; Leite, Tatiana S.

; Simone, Luiz R.L.

Zoologia (Curitiba)

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2023, Volume 40 elocation e23026

Abstract: En | Text: En | PDF: En

ABSTRACT The expression ‘you need to know to conserve’ is a well-known cliche among biologists. Documenting the richness of a group of organisms is the first step towards understanding biodiversity and preparing efficient conservation plans. In this context, many efforts have been made to quantify the number of species on Earth and estimate the number of species still unknown to science. A few countries have complete and integrated databases estimating the approximate number of species recorded for their territory, particularly in the Global South. In Brazil, a country of continental dimensions, revealing the richness of the second most diverse clade of invertebrates (=Mollusca) has been a goal of taxonomists. Recently, in an unprecedented, collective, and integrated effort among Brazilian malacologists, it was possible to estimate how many valid species of molluscs are there in Brazil. In this effort, more than 30 mollusc experts joined together to update the Taxonomic Catalogue of the Brazilian Fauna (TCBF), a governmental website that allows a quick and real-time updating of all Metazoan. So far, more than 5,000 updates have been made in TCBF, indicating the presence of 3,552 valid species of molluscs in Brazil, distributed among the main clades as follows: Caudofoveata (10 spp.), Solenogastres (6 spp.), Polyplacophora (35 spp.), Scaphopoda (43 spp.), Cephalopoda (92 spp.), Bivalvia (629 spp.) and Gastropoda (2,737 spp.). The present study, in addition to demonstrating for the first time the richness of Brazilian molluscs, also presents the state of the art of this important phylum of invertebrates highlighting its most representative and neglected groups.

https://doi.org/10.1590/s1984-4689.v40.e23026

Evaluation of Fully Biodegradable PLA/PHB Blend Filled with Microcrystalline Celluloses
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Iulianelli, Gisele C. Valle

; Costa, Lucas Viana

; Silva, Paulo Sérgio Cruz da

; Santos, Fernanda Abbate dos

Materials Research

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2023, Volume 26 elocation e20220433

Abstract: En | Text: En | PDF: En

In this work, biodegradable biocomposites were developed using PLA/PHB blend as matrix and two types of microcrystalline cellulose as filler at three different contents. The biocomposites were evaluated regarding their thermal and morphological characteristics and molecular dynamic behavior. It was seen that cellulose addition did not promote significant changes in the Tm, Tc and Tcc in the matrix. On the other hand, XRD and TGA revealed that the addition of the highest content (7 wt%) of cellulose fillers resulted in a more significant decrease in crystallinity and thermal stability of the PLA/PHB matrix, suggesting a formation of filler aggregates. This indication was confirmed by TD-NMR, whose results pointed to a greater heterogeneity molecular in the samples containing higher cellulose contents. Therefore, this technique proved to be a relevant and complementary tool for the characterization of composites materials, contributing to determinate the most appropriate filler content introduced in a polymer matrix.

https://doi.org/10.1590/1980-5373-mr-2022-0433

Hydrographic structure of the continental shelf in Santos Basin and its causes: The SANAGU and SANSED campaigns (2019)
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Dottori, Marcelo

; Sasaki, Dalton K.

; Silva, Danilo A.

; Del–Giovannino, Sergio R.

; Pinto, Andressa P.

; Gnamah, Magnim

; Santos, Arian D.

; Silveira, Ilson C. A. da

; Belo, Wellington C.

; Martins, Renato P.

; Moreira, Daniel L.

Ocean and Coastal Research

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2023, Volume 71 Suppl. 3 elocation e23013

Abstract: En | Text: En | PDF: En

Abstract This study describes the hydrography and water masses of the Santos Basin Continental Shelf (SBCS) during two hydrographic campaigns (SANAGU, SANSED) in 2019. Coastal Water (CW) is the dominant water mass in the southern portion of the SBCS, with relatively low salinity values (S<35.5 g kg–1), and satellite data show that local precipitation and river discharge could not account for the low salinity observed during the cruises in the southern region of the domain. The low salinity observed is explained by the transport from the south influenced by Subtropical Shelf Water (STSW), which was influenced by the La Plata River discharge. In the northern region of the SBCS, the South Atlantic Central Water (SACW) dominates the bottom layers of the water column, with the wind playing a major role in the uplift of this water mass, as evidenced by a wind impulse analysis. In this part of the shelf, Tropical Water (TW) was the second water mass in volume and occupied the surface layers and offshore the shelf. CW is restricted to a thin surface layer, which reaches distances of a few kilometers from the coast. Our analysis show the differences in the hydrographic structure of the SBCS and suggests that the SBCS can be divided in two regions with distinct characteristics: 1) the area southwest of São Sebastião, where the hydrographic parameters were modulated by the presence of the Subtropical Shelf Water (STSW); 2) the area northeast of São Sebastião, where the uplifting of SACW was the dominant process.

https://doi.org/10.1590/2675-2824071.22062md

Evaluation of shear design criteria of beams according to NBR6118 applying the modified compression field theory
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Sá, Marcelo Araújo de

; Santos, Sergio Hampshire de Carvalho

; Silva Filho, Julio Jeronimo Holtz

Revista IBRACON de Estruturas e Materiais

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2023, Volume 16 N. 3 elocation e16309

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract It is known that design deficiencies in shear design are more dangerous than bending, as shear failures can occur in a fragile way and without possibility of redistributing internal forces. Unlike bending design, designing for shear loads by different standards can generate significantly different results for the same element, as long as design models have been under discussion for many years. This paper analyses the evaluation of the behavior of the combined bending and shear loads in reinforced concrete beams for different pairs of these forces. For this purpose, the verification presented in ABNT NBR 6118 was used and compared to a more improved theory currently used, the Modified Compression Field Theory - MCFT. This theory is able to predict the relationships of specific loads and strains, as well as the shear strength of sections with great precision, being parameterized by several tested elements. As the use of this theory is not practical for manual calculations, the Response-2000 software, developed at the University of Toronto by Evan C. Bentz, was used. The program allows the analysis of beams and columns subject to moments, shear forces and axial loads, for any type of geometry, material properties and reinforcement arrangement, resulting in accurate responses of the behavior of the sections using MCFT as a basis.

Resumo Sabe-se que deficiências de projeto no dimensionamento à força cortante são mais perigosas que as de flexão, pois rupturas por cisalhamento podem ocorrer de forma frágil e sem possibilidade de redistribuição dos esforços internos. Diferentemente do dimensionamento à flexão, o dimensionamento a solicitações cisalhantes por diferentes normas, podem gerar resultados significativamente distintos para um mesmo elemento, visto que os modelos de dimensionamento seguem em discussão por muitos anos. Este trabalho considera a avaliação do comportamento da ação das solicitações combinadas de flexão e força cortante em vigas de concreto armado para diferentes pares de momentos fletores e forças cortantes. Para tanto foi utilizada a verificação definida na ABNT NBR 6118, comparada a uma teoria mais aprimorada utilizada atualmente, a Teoria do Campo de Compressão Modificada (Modified Compression Field Theory - MCFT). Essa teoria é capaz de prever as relações entre carregamentos e deformações específicas, bem como a resistência à força cortante de seções com grande precisão, sendo parametrizada por diversos elementos ensaiados. Como a utilização dessa teoria não é prática para os cálculos manuais, foi utilizado o software Response-2000, desenvolvido na Universidade de Toronto por Evan C. Bentz. O programa permite a análise de vigas e pilares sujeitos a momentos, forças cortantes e cargas axiais, para qualquer tipo de geometria, propriedades de materiais e arranjo de armaduras, resultando em respostas precisas do comportamento das seções utilizando como base a MCFT.

https://doi.org/10.1590/s1983-41952023000300009

Physical, chemical and sensory implications of pequi (Caryocar brasiliense Camb.) sweet bread made with flour, pulp and fruit by-product
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CUNHA, MARIANA C. DA

; TERRA, LAILA H.

; CAMPOS E SOUSA, PIÊTRA

; VILELA, DAIANA R.

; OLIVEIRA, ANA LÁZARA

; SILVA, JÉSSYCA S.

; SIMÃO, SÉRGIO DOMINGOS

; PEREIRA, JOELMA

; ALVES, JOSÉ GUILHERME L.F.

; CARVALHO, ELISÂNGELA ELENA N. DE

; VILAS BOAS, EDUARDO V.B.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 2 elocation e20201550

Abstract: En | Text: En | PDF: En

Abstract This study aimed to develop and evaluate bread with the use of pulp and flours of pequi, in partial replacement of water and wheat flour, to develop a bakery product with good technological, nutritional and sensorial qualities. The pequi husk and pulp flours were obtained by means of a thermal pre-treatment, oven drying and standardization of the dry material. Whereas, the bread formulation was defined through the baker’s formulation. Besides, the dehydration process caused significant changes (p<0.05) in the L* value and chromaticity (C*), mainly of the flours (husk and pequi pulp), such changes are due to non-enzymatic oxidative processes and pigment degradation, especially carotenoids. The effect of the substitution of ingredients (wheat flour and water) by husk and pulp flours and pequi pulp contributed to the increase in lipid, crude fiber, nitrogen-free extract and energy value content. However, the substitution promoted changes in the attributes of color and textural properties, such as increased hardness, chewiness and cohesiveness. Nevertheless, all formulations showed good sensory acceptance and thus, pequi sweet breads can be implemented in school meals for contributing and meeting the nutritional recommendations established by the School Feeding Brazilian Program (PNAE).

https://doi.org/10.1590/0001-3765202320201550

Imputation of precipitation data in northeast Brazil
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RODRIGUES, DANIELE T.

; GONÇALVES, WEBER A.

; SILVA, CLÁUDIO MOISÉS S. E

; SPYRIDES, MARIA HELENA C.

; LÚCIO, PAULO SÉRGIO

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 2 elocation e20210737

Abstract: En | Text: En | PDF: En

Abstract This article evaluates four statistical methods of multiple imputation to fill in the missing data of daily precipitation in Northeast Brazil (NEB). We used a daily database collected by 94 rain gauges distributed in NEB from January 1, 1986 to December 31, 2015. The methods were: random sampling from the observed values; predictive mean matching, Bayesian linear regression; and bootstrap expectation maximization algorithm (BootEm). To compare these methods, missing data from the original series were initially excluded. The next step was to create three scenarios for each method, in which 10\%, 20\% and 30\% of the data were removed at random. The BootEM method presented the best statistical results. With the average bias between the complete series and the imputed series values ranging between -0.91 and 1.30 mm/day. The values of the Pearson correlation ranging between 0.96, 0.91 and 0.86 respectively for 10\%, 20\% and 30\% missing data. We conclude that this is an adequate method for the reconstruction of historical precipitation data in NEB.

https://doi.org/10.1590/0001-3765202320210737

Stabilization of β-Galactosidase Encapsulated in Pectin-Alginate Hydrogel and Hydrolysis of Whey Lactose and Whole Milk
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Paiva, Maykon J.

; Paula-Elias, Fabrício C.

; Pereira, Luciana A.

; Carreiro, Solange C.

; Vieira-Almeida, Erika C.

; Silva, Ezequiel M.

; Dias, Giancarlo S.

; Xavier, Michelle A. C.

; Morales, Sergio A.

; Perna, Rafael F.

; Almeida, Alex F.

Journal of the Brazilian Chemical Society

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2023, Volume 34 N. 12 Pages 1743 - 1752

Abstract: En | Text: En | PDF: En

The operational conditions of β-galactosidase encapsulated in pectin-alginate hydrogel were investigated as well as its catalytic activity in the hydrolysis of lactose from whey and whole milk. β-Galactosidase encapsulated in pectin-alginate hydrogel showed the best results to yields and diffusional effect and pH range. Thermostability showed considerable income gain for half-life (1.7-fold), activation energy of denaturation (31.6-fold), activation of denaturation (217.3-fold at 40 ºC; 266.8-fold at 50 ºC; 345.6-fold at 60 ºC), and entropy of activation of denaturation (-42.0 J mol 1 K-1). Reusability of encapsulated β-galactosidase was observed in 8-cycles for the milk whey lactose hydrolysis (51.9%) and 7-cycles for whole milk (55.6%), and the lactose hydrolysis was observed in 13% in milk whey and 10.3% in whole milk after 10 cycles. These results revealed an industrial application potential of β-galactosidase encapsulated in pectin-alginate hydrogel for lactose hydrolysis of milk whey and whole milk processes.

https://doi.org/10.21577/0103-5053.20230067

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Suppl. 3 elocation e23022

Abstract: En | Text: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

10.

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Publication date: 2022-10-11

Abstract: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

11.

Fruit characteristics of cantaloupe melon in protected environment subjected to irrigation frequencies and substrate volumes
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Andrade, Sérgio P.

; Silva, Tonny J. A. da

; Silva, Edna M. B.

; Arantes, Sayonara A. do C. M.

; Arruda Júnior, Alcides

Revista Brasileira de Engenharia Agrícola e Ambiental

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oct 2022, Volume 26 N. 10 Pages 706 - 712

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo deste estudo foi avaliar o efeito de frequências de irrigação e volumes de substratos sobre a massa de frutos, qualidade de frutos e eficiência do uso da água de melão cantaloupe em ambiente protegido. O estudo foi conduzido na Universidade Federal de Rondonópolis, MT, de fevereiro a agosto de 2021, em delineamento de blocos ao acaso em esquema fatorial 3 × 4 com quatro repetições. Os volumes de substrato utilizados nos vasos plásticos foram de 5, 10 e 15 dm3 e as frequências de irrigação foram uma vez ao dia, duas vezes ao dia, três vezes ao dia e uma vez a cada dois dias. As características avaliadas foram massa de fruto, espessura da polpa, eficiência de uso da água, teor de sólidos solúveis e acidez titulável. As frequências de irrigação de uma e três vezes ao dia apresentaram melhor desempenho para massa de fruto e espessura da polpa. A eficiência do uso da água foi maior para a frequência de três vezes ao dia. Com exceção da acidez titulável, os volumes de substrato de 10 e 15 dm3 apresentaram os maiores desempenhos para todas as variáveis avaliadas. Quanto ao teor de sólidos solúveis os frutos apresentaram níveis que os classificaram como frutos extra, de alta qualidade e indicados para exportação.

ABSTRACT The objective of this study was to evaluate the effect of irrigation frequencies and substrate volumes on fruit mass, fruit quality and water use efficiency of cantaloupe melon in protected environment. The study was conducted at the Federal University of Rondonópolis, MT, Brazil, from February to August 2021, in randomized block design in a 3 × 4 factorial scheme with four replicates. The substrate volumes used in plastic pots were 5, 10 and 15 dm3 and the irrigation frequencies were once a day, twice a day, three times a day and once every other day. The characteristics evaluated were fruit mass, pulp thickness, water use efficiency, soluble solids content, and titratable acidity. The irrigation frequencies of once and three times a day showed the best performance for fruit mass and pulp thickness. The water use efficiency was higher for the frequency of three times a day. With the exception of titratable acidity, the substrate volumes of 10 and 15 dm3 showed the highest performances for all the variables evaluated. As for the soluble solids content, all fruits showed levels that classified them as extra fruits, of high quality and indicated for exportation.

https://doi.org/10.1590/1807-1929/agriambi.v26n10p706-712

12.

Definition and management of very high fracture risk in women with postmenopausal osteoporosis: a position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Association of Bone Assessment and Metabolism (ABRASSO)
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Silva, Barbara C.

; Madeira, Miguel

; d’Alva, Catarina Brasil

; Maeda, Sergio Setsuo

; Holanda, Narriane Chaves Pereira de

; Ohe, Monique Nakayama

; Szejnfeld, Vera

; Zerbini, Cristiano A. F.

; Paula, Francisco José Albuquerque de

; Bandeira, Francisco

Archives of Endocrinology and Metabolism

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oct 2022, Volume 66 N. 5 Pages 591 - 603

Abstract: En | Text: En | PDF: En

ABSTRACT Several drugs are available for the treatment of osteoporosis in postmenopausal women. Over the last decades, most patients requiring pharmacological intervention were offered antiresorptive drugs as first-line therapy, while anabolic agents were considered a last resource for those with therapeutic failure. However, recent randomized trials in patients with severe osteoporosis have shown that anabolic agents reduce fractures to a greater extent than antiresorptive medications. Additionally, evidence indicates that increases in bone mineral density (BMD) are maximized when patients are treated with anabolic agents first, followed by antiresorptive therapy. This evidence is key, considering that greater increases in BMD during osteoporosis treatment are associated with a more pronounced reduction in fracture risk. Thus, international guidelines have recently proposed an individualized approach to osteoporosis treatment based on fracture risk stratification, in which the stratification risk has been refined to include a category of patients at very high risk of fracture who should be managed with anabolic agents as first-line therapy. In this document, the Brazilian Society of Endocrinology and Metabolism and the Brazilian Association of Bone Assessment and Metabolism propose the definition of very high risk of osteoporotic fracture in postmenopausal women, for whom anabolic agents should be considered as first-line therapy. This document also reviews the factors associated with increased fracture risk, trials comparing anabolic versus antiresorptive agents, efficacy of anabolic agents in patients who are treatment naïve versus those previously treated with antiresorptive agents, and safety of anabolic agents.

https://doi.org/10.20945/2359-3997000000522

13.

Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
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Soares, Fábia C. S.

; Araújo, Romário M.

; Werkhauser, Roberto P.

; Diniz, George T.

; Bhaskar, Lakkakula V.K.S

; Carvalho, Viviane D. C. V.

; Tashiro, Tetsuo

; Amorim, Ester A. S.

; Silva, Lilian C. A.

; Montenegro, Sergio Tavares

; Neco, Heytor V. P. C.

; Moraes, Clarice N. L.

; Martins, Danyelly B. G.

; Montenegro, Silvia M. L.

International Journal of Cardiovascular Sciences

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aug 2022, Volume 35 N. 4 Pages 444 - 456

Abstract: En | Text: En | PDF: En

Abstract Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study is to determine the association between variants in the NPY and NPY2R genes, as well as the severity of acute coronary syndrome (ACS). Methods Approximately 221 ACS patients and 278 healthy controls were selected for this study. Four variants in NPY and two variants in NPY2R genes were genotyped using Taqman allelic discrimination and sequencing. The Chi-square and Fisher's exact tests were used to verify the genotype frequencies. The logistic regression analyses were used for the evaluation of the studied variables. Haplotype analysis was used to evaluate the linkage disequilibrium (LD) between the variants (p<0.05). Results An association of NPY c.20T>C variant was found with the ACS group when compared to the healthy group. In the analysis between variants and risk factors in the ACS group, NPY c.84G>A was associated with hypertension. The analysis between TIMI risk showed a significance for NPY c.20T>C between the low and intermediate/high TIMI risk groups. In the haplotype analysis, strong linkage disequilibrium (LD) was found between the variants NPY c.150G>A and NPY c.-485T>C. Conclusion The NPY c.20T>C variant appears to contribute to the development of ACS. The NPY2R c.-1116A>G variant may contribute to the early development of ACS and the NPY c.84G>A variant appears to contribute to the development of hypertension. In addition, the NPY c.20T>C is associated with a protective effect in ACS severity.

https://doi.org/10.36660/ijcs.20210053

14.

Volviéndonos mejores: necesidad de acción inmediata ante el reto de la obesidad. Una postura de profesionales de la salud
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Barquera, Simón

; Véjar-Rentería, Lesly Samara

; Aguilar-Salinas, Carlos

; Garibay-Nieto, Nayely

; García-García, Eduardo

; Bonvecchio, Anabelle

; Perichart, Otilia

; Torres-Tamayo, Margarita

; Esquivias-Zavala, Héctor

; Villalpando-Carrión, Salvador

; García-Méndez, Rosalba Carolina

; Apolinar-Jiménez, Evelia

; Kaufer-Horwitz, Martha

; Martínez-Montañez, Olga Georgina

; Fajardo Niquete, Ileana

; Aguirre-Crespo, Alejandra

; Gómez-Álvarez, Enrique

; Hernández-Jiménez, Sergio C.

; Denova-Gutiérrez, Edgar

; Batis, Carolina

; Elías-López, Daniel

; Palos-Lucio, Ana Gabriela

; Vásquez-Garibay, Edgar M.

; Romero-Velarde, Enrique

; Ortiz-Rodríguez, María Araceli

; Almendra-Pegueros, Rafael

; Contreras, Alejandra

; Nieto, Claudia

; Hernández-Cordero, Sonia

; Munguía, Ana

; Rojas-Russell, Mario

; Sánchez-Escobedo, Samantha

; Delgado-Amézquita, Elvia

; Aranda-González, Irma

; Cruz-Casarrubias, Carlos

; Campos-Nonato, Ismael

; García-Espino, Fátima

; Martínez-Vázquez, Sophia

; Arellano-Gómez, Laura P.

; Caballero-Cantú, Idalia

; Hunot-Alexander, Claudia

; Valero-Morales, Isabel

; González-González, Lorena

; Ríos-Cortázar, Víctor

; Medina-García, Catalina

; Argumedo, Gabriela

; Calleja-Enríquez, Carmen Rosa

; Robles-Macías, Edna

; Nava-González, Edna J.

; Lara-Riegos, Julio

; Sánchez-Plascencia, Ana K.

; Hernández-Fernández, Mauricio

; Rodríguez-Núñez, Jose Luis

; Rangel-Quillo, Sarai

; Cancino-Marentes, Martha Edith

; Hernández-Viana, Mónica J.

; Saldivar-Frausto, Mariana

; Álvarez-Ramírez, Miriam

; Sandoval-Salazar, Cuauhtémoc

; Silva-Tinoco, Rubén Oswaldo

; Moreno-Villanueva, Mildred

; Villarreal-Arce, María Elena

; Barriguete, J. Armando

; White, Mariel

; Jauregui, Alejandra

; Tolentino-Mayo, Lizbeth

; López-Ridaura, Ruy

; Rivera-Dommarco, Juan

Salud Pública de México

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apr 2022, Volume 64 N. 2 Pages 225 - 229

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: In recent decades, the growing obesity epidemic in Mexico has become one of the most important public health challenges faced by the country. With support from the World Obesity Federation, we formed a working group in 2021 to identify and summarize priority actions that Mexico can take to face this epidemic. More than 1 000 health professionals joined the development and discussion process. Recommendations from previously published, high-level documents and guidelines were taken into account. In commemoration of World Obesity Day 2022, this statement is presented as input for health care professionals to develop actions to address obesity. The statement includes 10 recommendations that include population-level and individual-level actions. It emphasizes the importance of social participation, comprehensive interventions with a person- centered perspective, planetary sustainability, on improving education and communication campaigns, as well as fostering a built environment that promotes active living, and shielding prevention and control efforts from conflicts of interest. The statement calls for obesity to be treated seriously, based on scientific evidence, in a timely and comprehensive manner, employing a life-course and ethical approach that does not perpetuate weight stigma in society.

resumen está disponible en el texto completo

https://doi.org/10.21149/13679

15.

A new species of Characidium (Characiformes: Crenuchidae) from the rio Doce basin, Brazil
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Oliveira-Silva, Leonardo

; Santos, Sérgio A. dos

; Lopes, Maridiesse Morais

; Zanata, Angela Maria

Neotropical Ichthyology

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2022, Volume 20 N. 1 elocation e210125

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Uma nova espécie de Characidium é descrita de afluentes do alto e médio curso da bacia do rio Doce, Minas Gerais, Brasil. A nova espécie se distingue da maioria das congêneres, exceto C. cricarense, C. hasemani, C. helmeri, C. kalunga, C. pterostictum, C. schubarti, C. summus e C. travassosi pela falta de escamas na área entre o limite anterior do istmo e a margem anterior do cleitro. A nova espécie difere das espécies acima mencionadas por uma série de caracteres, incluindo a presença de nadadeira adiposa, 2–4 escamas entre o ânus e a nadadeira anal, duas séries de dentes no dentário, ramo parietal do canal supraorbital presente, 4 séries de escamas acima da linha lateral e ausência de duas bandas escuras inclinadas em cada lobo da nadadeira caudal. A nova espécie difere ainda mais da maioria das congêneres com superfície ventral sem escamas no istmo por ter 33–34 escamas perfuradas na linha lateral e traços escuros nos raios da nadadeira caudal não formando bandas bem definidas.

Abstract A new species of Characidium is described from the tributaries of the upper and middle rio Doce basin, Minas Gerais, Brazil. The new species is distinguished from most congeners, except C. cricarense, C. hasemani, C. helmeri, C. kalunga, C. pterostictum, C. schubarti, C. summus, and C. travassosi by lacking scales in the area between the anterior limit of the isthmus and the anterior margin of cleithrum. The new species differs from the aforementioned species by a series of characters, including the presence of the adipose fin, 2–4 scales between the anus and anal fin, two rows of dentary teeth, presence of the parietal branch of the supraorbital canal, 4 scale rows above the lateral line, and absence of two conspicuous inclined dark bands on each caudal-fin lobe. The new species further differs from most congeners with an unscaled ventral surface of the isthmus by the presence of 33–34 pored scales on the lateral line and by the dark dashes on the caudal fin-rays not forming well-defined bands.

https://doi.org/10.1590/1982-0224-2021-0125

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