Abstract Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concentration, minimum bactericidal and fungicidal concentrations, and its antibiofilm activity were evaluated. The EO cytotoxicity was assessed in tumor and non-tumor human cells, and in vivo toxicity was evaluated in a Galleria mellonella model. The major constituents of S. terebinthifolia EO were alpha-phellandrene and beta-phellandrene. The EO had a weak activity against all strains of Candida albicans (MIC 1000μg/mL) and had no activity against non-albicans strains, bacteria, and C. albicans biofilm. Cytostatic activity against all tumor cell lines was shown. Additionally, cell viability remained at EO concentrations up to 62.5 μg/mL. At 16 mg/mL, 50% hemolysis was observed, and it had low toxicity in vivo. Overall, the S. terebinthifolia EO was characterized by low antimicrobial and antibiofilm activities, with no evidence of toxicity to human tumor and non-tumor cells.

ABSTRACT The use of salt stress attenuators is considered an important tool to minimize the deleterious effects of salts. However, its application to chives (Allium schoenoprasum L.) has not been studied. This study aimed to evaluate the induction of salt stress tolerance in chives plants in relation to growth and enzymatic reactions, when subjected to different salinity levels of the nutrient solution, after acclimation of seeds with hydrogen peroxide (H2O2) for 24 h. The experiment was conducted in a greenhouse, where chives seeds were acclimated by H2O2 at concentrations of 0.0, 0.15, 0.30, 0.45 and 0.60 mmol. After germination, the plants were cultivated in hydroponic system with electrical conductivities of 1.0, 2.0, 3.0, 4.0 and 5.0 dS m-1. Plant height, length and number of leaves, H2O2 content, malondialdehyde and catalase (CAT) activity were evaluated in chives plants. The increase in the salinity of the nutrient solution up to 5 dS m-1 reduced by 5.88%, 17% and 9.63% plant height, leaf length and number of leaves, respectively. It was observed that the acclimation of chives seeds with H2O2 at 0.45 mmol g-1 fresh mass in plants that were cultivated in nutrient solution of 3.73 dS m-1 led to maximum CAT activity, minimizing the deleterious effects of nutrient solution salinity on plant growth.

RESUMO Os problemas de salinização da água e do solo são cada vez mais frequentes em regiões áridas e semiáridas, sendo necessária a adoção de tecnologias que viabilizem o uso desses recursos naturais na agricultura, permitindo que haja desenvolvimento vegetal satisfatório. Com isso, objetivou-se estudar os efeitos da irrigação com água salina associada a doses de fósforo sobre a salinidade do solo e acúmulo de fitomassa e o teor de nutrientes em plantas de feijão-caupi. A pesquisa foi realizada em casa de vegetação usando o delineamento de blocos casualizados em esquema fatorial 5 x 3 constituído de cinco condutividades elétricas da água de irrigação (0,5; 1,5; 2,5; 3,5 e 4,5 dS m-1) e três doses de fósforo (60, 100 e 140% da dose recomendada - 60 kg P2O5 ha-1), com cinco repetições. As plantas foram cultivadas em lisímetros de 8 dm3, até à fase de floração, e nesse período foi avaliado a salinidade do solo, o acúmulo de fitomassa e os teores de nutrientes no tecido vegetal. A irrigação com água com condutividade elétrica acima de 2,5 dS m-1 elevou a salinidade do solo e teor de sódio nos tecidos a níveis tóxicos, reduzindo a fitomassa e os teores de macronutrientes no tecido vegetal do feijão-caupi, com exceção do nitrogênio. A aplicação de 60% da dose recomendada de fósforo para o feijão-caupi melhora a homeostase iônica da cultura, aumentando a absorção de potássio e cálcio, porém sem diminuir os efeitos deletérios da alta salinidade no acúmulo de fitomassa.

HIGHLIGHTS Irrigation using water with electrical conductivity above 2.5 dS m-1 is not adequate for ‘Paulistinha’ cowpea. Increment in phosphorus dose does not increase phosphorus content in cowpea plant. Under salt stress conditions, cowpea plants require lower doses of phosphorus.

RESUMO O objetivo do presente estudo foi avaliar as mudanças no metabolismo osmorregulador de genótipos de algodoeiro submetidos ao déficit hídrico e ao período de recuperação. Em casa de vegetação, seis genótipos de algodoeiro e dois manejos hídricos foram combinados em esquema fatorial 6 x 2, em delineamento inteiramente casualizado, avaliados após 14 e 22 dias em condições de estresse hídrico e recuperação, respectivamente. Foram avaliados o status hídrico, indicadores de crescimento e solutos compatíveis em folhas. Os genótipos BRS Seridó, BRS Aroeira e BRS 7MH suportam melhor a condição de estresse por apresentarem menores variações nos seus potenciais hídricos devido ao ajustamento osmótico e por manterem seu crescimento em condições de deficit hídrico. O BRS 286 é o genótipo mais sensível à condição de deficit hídrico, pois apresentou maiores variações no seu potencial hídrico que repercutiu na paralização do seu crescimento. A reposição hídrica durante o período de recuperação permitiu a retomada do crescimento da maioria dos genótipos, principalmente CNPA 5M e BRS 286. Após o período de recuperação hídrica, as variações nas concentrações dos osmorreguladores indicam plasticidade do algodoeiro em regular os níveis de osmorreguladores em condições favoráveis e desfavoráveis de água.

ABSTRACT The aim of this study was to evaluate the changes in osmoregulatory metabolism of cotton genotypes subjected to water deficit and recovery period. In a greenhouse, six cotton genotypes and two water managements were combined in a 6 x 2 factorial scheme, in a completely randomized design, evaluated after 14 and 22 days under water stress and recovery conditions, respectively. The water status, growth indicators and compatible solutes in the leaves were evaluated. The genotypes BRS Seridó, BRS Aroeira and BRS 7MH withstand better the stress condition because they had lower variations in their water potentials due to the osmotic adjustment and maintained their growth under water deficit conditions. The BRS 286 is the most sensitive genotype to the water deficit condition, since it showed greater variations in its water potential, which ultimately stopped its growth. Water replacement during the recovery period allowed growth resumption in most of the genotypes, mainly CNPA 5M and BRS 286. After the recovery period, variations in the concentrations of osmoregulators indicate the plasticity of cotton in regulating the concentrations of osmoregulators under favorable and unfavorable water conditions.

ABSTRACT Croton zehntneri Pax & K. Hoffm., Euphorbiaceae, or “canela-de-cunhé” is used in the Northeast Brazil to treat several diseases. Leaves and aerial parts of C. zehntneri are rich in volatile oil of high potential therapeutic. This study aimed to investigate volatile oil systemic toxicity after per oral treatment in rats. Volatile oil characterization (gas chromatography and mass spectrometry) showed 85.7% anethole and 4.8% estragole. Male Wistar rats (116–149 g) were treated with volatile oil (250 mg/kg p.o.) during ten weeks and evaluated for the following parameters: survival; food and water intake; body mass; absolute/relative organs weight; hemogram; plasma biochemical dosage; organs morphology. Volatile oil did not alter animal water and food consumption or the relative/absolute weight of most organs, but animals gained less weight. Volatile oil did not alter function biomarkers of pancreas, kidney, heart or liver, but increased plasma gamma-glutamyltranspeptidase (liver biomarker) and decreased uric acid (kidney biomarker). Although volatile oil had caused discrete morphological alterations in some organs, it did not induce architectural changes in these organs. In conclusion, the sub-acute per oral treatment with volatile oil no longer than ten weeks in rats offers small toxicity at doses below 250 mg/kg.

RESUMO: A capivara (Hydrochoerus hydrochaeris) é o maior roedor do mundo. No estado do Acre, Brasil, as populações de capivaras têm aumentado significativamente. O papel das capivaras na transmissão de certas infecções zoonóticas bacterianas não é bem compreendido, incluindo as bactérias do gênero Salmonella. Salmonella spp. geralmente causam enterite ou septicemia em mamíferos, porém muitas espécies de mamíferos podem carregar a bactéria de forma assintomática e eliminá-la em suas fezes. Para entender melhor o possível papel das capivaras como reservatórios de Salmonellaspp., realizamos um estudo para identificação de Salmonella spp. em amostras fecais de capivaras no Acre. Em uma amostra de conveniência, 54 capivaras de duas áreas urbanas e duas áreas rurais do Acre foram capturadas e mantidas por três a quatro dias para amostragem. Nenhum dos animais era sintomático de qualquer doença intestinal. Três amostras fecais foram coletadas de cada animal, durante sua permanência em cativeiro. Cada amostra foi cultivada para a presença de Salmonella spp. no Laboratório de Bacteriologia Veterinária da Universidade Federal do Acre. As amostras foram semeadas em caldo de pré-enriquecimento tetrationato e em peptona de caldo de pré-enriquecimento. Após 24 horas de incubação, todas as amostras foram semeadas em ágar MacConkey (MC) e ágar Salmonella-Shigella (SS). Colônias sugestivas foram submetidas a análises bioquímicas. Colônias compatíveis com Salmonella de acordo com o perfil bioquímico foram submetidas à sorotipagem (Sorokit para Salmonella - Probac do Brasil). Além disso, a primeira amostra de cada uma das 54 capivaras foi testada para Salmonella spp. usando PCR, visando gene hilA. Oito (5%) das 162 amostras examinadas por cultura bacteriana foram positivas para Salmonella spp. Enquanto quatro (7%) das 54 examinadas pela PCR foram positivas. Dos oito animais positivos em cultura, cinco eram de área urbana e três de área rural. Na PCR, apenas um animal positivo era de área urbana e quatro de área rural. Considerando o diagnóstico conjunto por ambos os testes, PCR e cultura, um animal foi considerado positivo. Todas as amostras foram coletadas em animais livres, sem sinais clínicos aparentes de salmonelose, indicando o potencial da capivara como reservatório nesse ecossistema.

ABSTRACT: The capybara (Hydrochoerus hydrochaeris) is the largest rodent in the world. In the state of Acre, Brazil, populations of capybaras have been increasing significantly. The role of capybaras in the transmission of certain bacterial zoonotic infections is not well understood, including bacteria of the genus Salmonella. Salmonella spp. generally cause enteritis or septicemia in mammals, however many mammalian species can carry the bacteria asymptomatically and shed it in their feces. To better understand the possible role of capybaras as reservoirs of Salmonella spp., we conducted a study of Salmonella within fecal samples from capybara in Acre. In a convenience sample, 54 capybaras from two urban and two rural areas of Acre were captured and kept for three to four days for sampling. None of the animals were symptomatic of any intestinal illness. Three separate fecal samples were collected from each animal, during their stays in captivity. Each sample was cultured for the presence of Salmonella spp. at the bacteriology laboratory of the Veterinary College of the Federal University of Acre. Samples were seeded in tetrationate pre-enrichment broth and in pre-enrichment broth peptone. After a 24 hour of incubation all samples were streaked on MacConkey Agar (MC) and Salmonella-Shigella Agar (SS). Suggestive colonies were submitted to biochemical analysis. Salmonella compatible colonies according to biochemical profile were submitted to serotyping (Sorokit for Salmonella - Probac do Brasil). In addition, the first sample from each of the 54 capybara was tested for Salmonella spp. using PCR targeting gene hilA. Eight (5%) of the 162 samples examined by bacterial culture were positive for Salmonella spp., while four (7%) of the 54 examined by PCR were positive. From the eight positive animals on culture, five were from urban area and three from rural area. On PCR, only one positive animal was from urban area and four were from rural area. Overall, by either test, one of the 54 animals was positive. All samples were collected in free - living animals with no apparent clinical signs of salmonellosis, indicating the potential of capybara as reservoir on this ecosystem.

The secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI50 values of 2.28, 3.29 and 5.76 mol L-1, respectively.

ABSTRACT The secondary metabolites of the aerial parts of Zornia brasiliensis Vogel, Fabaceae, and the biological activity of one of these secondary metabolites were characterized in this study. A phytochemical investigation was performed using chromatographic techniques including analytical and preparative reverse-phase HPLC column sequences, which resulted in the isolation of fourteen compounds: one previously undescribed C-glycosylated dihydrochalcone (zornioside), one cyclitol (D-pinitol), one glycosylated megastigmane (roseoside) and eleven phenolic compounds: 7-methoxyflavanone, 7,4'-dimethoxyisoflavone, medicarpin, 2'-4'-dihydroxychalcone, onionin, isoorientin-3'-O-methyl ether, isovitexin, glycosylated (Z)-O-coumaric acid, glycosylated (E)-O-coumaric acid, dihydromelilotoside, and isoorientin. The structures of the isolated compounds were determined based on 1D and 2D-NMR, HRESIMS, IR and CD spectroscopic analyses. The cytotoxic activity of zornoside was assessed against tumor cell lines (MCF-7, HCC1954, T-47D, 4T1, HL60), and a non-tumor cell line (RAW264.7) using MTT assay. The compound zornioside was selectively cytotoxic for HL60 leukemia cells (IC50: 37.26 µM).

RESUMO Objetivou-se, neste trabalho, avaliar o crescimento da alface crespa em cultivo hidropônico, seguindo a técnica do fluxo laminar de nutrientes (NFT), utilizando soluções nutritivas minerais e organominerais otimizadas. Instalou-se um experimento em blocos casualizados com o uso de parcelas subdivididas, com três repetições. As parcelas corresponderam a oito soluções nutritivas, sendo quatro minerais com composição química sugeridas por Bernardes, Furlani, Castellane & Araújo e Ueda e quatro organominerais, sugeridas nesta pesquisa com composição química semelhante às soluções minerais, anteriormente citadas. As subparcelas corresponderam a três cultivares da alface crespa (Thaís, Vanda e Verônica). Aos 25 dias após o transplantio das mudas avaliaram-se as variáveis diâmetro do caule e da coroa, comprimento da raiz, área foliar e número de folhas. Para os diâmetros da coroa e do caule e número de folhas, as soluções minerais promoveram as maiores médias. A solução mineral de Furlani e as soluções organominerais, exceto a de Castellane & Araújo modificada, promoveram os maiores comprimentos de raízes; a menor área foliar foi obtida pela solução organomineral de Ueda. A cultivar Verônica apresentou os maiores comprimento de raiz e diâmetro caulinar.

ABSTRACT The objective of this study was to evaluate the growth of crisp lettuce in hydroponic cultivation, following the nutrient film technique (NFT), using optimized mineral and organomineral nutrient solutions. The experiment was set in 8 x 3 factorial scheme, with treatments distributed in randomized blocks and split plots, with three replicates. The plots corresponded to eight nutrient solutions, of which four were mineral solutions with chemical composition suggested by Bernardes, Furlani, Castellane & Araújo and Ueda, and four were organomineral solutions, suggested by this research with chemical composition similar to those of the previously mentioned mineral solutions. The subplots corresponded to three varieties of crisp lettuce: Thaís, Vanda and Verônica. At 25 days after transplanting, the following parameters were evaluated: stem and crown diameter, root length, leaf area and number of leaves. For stem and crown diameters and number of leaves, the mineral solutions promoted the highest means. The mineral solution of Furlani and the organomineral solutions, except the modified solution of Castellane & Araújo, promoted the greatest root lengths. The smallest leaf area was obtained in the organomineral solution of Ueda. The cultivar Verônica had the highest root length and stem diameter.

OBJECTIVES: To analyze angiotomographic parameters of juxtarenal aneurysms to assess the applicability of an endograft model to patients and to create in vitro and in vivo models to assess the new endograft. METHODS: A total of 49 patients with juxtarenal aneurysms were submitted to angiotomographic evaluation, and parameters such as the aortic diameter, the length of the neck, and the angulations of the celiac trunk, superior mesenteric artery and renal arteries; the distances between them; and anatomic variations were analyzed. Based on these parameters, an endograft model was developed and tested in a newly created in vitro model of juxtarenal aneurysm. An experimental model of juxtarenal aneurysm was then established in six pigs weighing 50-60 kg to assess the new endograft model. RESULTS: The angiotomographic parameters of juxtarenal aneurysm measured in this study were similar to those reported in the literature and allowed the development of an endograft based on the hourglass concept, which was applicable to 85.8% of the patients. The in vitro model of juxtarenal aneurysm evidenced good radiopacity and functionality and permitted adjustments in the new device and technical improvements in the procedures for treating these aneurysms. In addition, the porcine model of juxtarenal aneurysm was successfully created in all six animals using a bovine pericardial patch, and use of the new endograft in three pilot procedures evidenced its feasibility. CONCLUSIONS: The Hourglass endograft was rendered applicable to treatment of the majority of patients with juxtarenal aneurysms simply by changing its diameter. Moreover, the new in vitro and in vivo models were shown to be effective for assessing both the presented endograft and experiments assessing the endovascular treatment of juxtarenal aneurysms.

O objetivo deste trabalho foi avaliar a compressibilidade de um Argissolo Amarelo distrocoeso submetido a diferentes sistemas de manejo sob cultivo de cana-de-açúcar. O experimento foi realizado em áreas da Usina Triunfo Industrial, AL, onde se avaliaram os manejos: MA - mata nativa; MSI - manejo sem irrigação; MCI - manejo com irrigação e MCV - manejo com fertirrigação (vinhaça). Todas as áreas estudadas, exceto no MA, vêm utilizando o preparo convencional do solo com uso de grades pesadas. As amostras de solo foram coletadas nas profundidades de 0-20 e 20-40 cm. Trincheiras foram abertas nas quatro áreas de manejo em estudo, quando amostras de solo indeformadas foram retiradas com auxílio de aneis metálicos de 6,4 cm diâmetro e 2,5 cm de altura em cada profundidade. Após coletadas, as amostras foram saturadas e submetidas a sucções de 0,1 a 10 kPa; 50, 500 e 1500 kPa, levadas à prensa mecânica e realizado o ensaio de compressibilidade. A partir dos dados obtidos determinou-se a tensão de preconsolidação (σp) das diversas amostras ensaiadas, cujos resultados foram submetidos à análise de regressão para a variável tensão de preconsolidação, em função da sucção matricial do solo. Em todos os manejos, a profundidade de 0-20 cm mostrou ser a mais susceptível à compactação em relação à profundidade de 20-40 cm; o manejo MCV alterou o comportamento compressivo do solo em ambas as profundidades (0-20 e 20-40 cm) e a capacidade de suporte do solo foi maior em todos os manejos, nas camadas de 20-40 cm.

The objective of this paper was to evaluate the compressibility of an Ultisol submitted to different managements of sugarcane cultivation. The investigation was carried out at Triunfo Mill, in the State of Alagoas, Brazil. The testing area was composed by four distinct sub-areas: a preserved forest (NF), an area without irrigation (MWOI), an irrigated area (MWI), and an area with vinasse (MWV). All investigated areas, except the forest, were prepared using conventional equipment for soil preparation. Soil samples were collected within depths ranging from 0 to 20 cm, 20 to 40 cm, and 40 to 60 cm. A trench was dug in the four selected areas and four undeformed samples were collected in each depth. The samples were collected with metallic rings with dimensions of 6.4 cm in diameter and 2.5 cm in height. In the laboratory, the samples were previously saturated and submitted to soil suctions raging from 0.1 to 1500 kPa in order to build the soil-water characteristic curves. Confined compression tests were performed with saturated samples. The results obtained from the compression tests were used for the determination of the void ratio (e) and the pre-consolidation stress (σp) of the tested samples. Data were submitted to regression analysis and the differences among the obtained means were compared using the test of Tukey at 5% of probability. Regression analysis for pre-consolidation stress in function of water content (Ug) and correlations among the several variables were carried out at 5-% significance. Within all investigated areas, the depth range from 0 to 20 cm showed to be more susceptible to compaction in relation to the depth range from 20 to 40 cm. Management MWV was found to modify the compressive behavior of the soil in both depth ranges. In all investigated areas, the soil bearing capacity was higher in the depth range of 20 to 40 cm.

Este trabalho avalia as principais propriedades do carvão de Manilkara amazonica (maçaranduba), Lecythis pisonis (sapucaia) e Piptadenia suaveolens (timborana), carbonizadas em sete e dez dias. O carvão foi produzido a partir de resíduos da serraria da Empresa Cikel Brasil Verde S. A., na Fazenda Rio Capim, em Paragominas. Foram utilizados 30 fornos de alvenaria, sendo dez fornos para cada espécie, dos quais cinco para carbonização em sete dias e cinco para dez dias. Após a carbonização, foram retiradas amostras de carvão produzido para estudo de rendimento gravimétrico e de propriedades físicas, químicas e mecânicas. Os principais resultados foram: o rendimento gravimétrico do carvão variou de 21,47 a 29,59 % (base úmida); a densidade média a granel, variou de 178,51 a 231,14 kg.m-3; a densidade média aparente foi de 0,38 a 0,53 g.cm-3; o poder calorífico foi de 23451 a 28830 kj.kg-1; o teor de materiais voláteis variou de 23,94 a 31,47%; cinzas de 0,7 a 2,5%; o carbono fixo de 68,29 a 74,49%; e a friabilidade de 12 a 32,6%. Constatou-se que a espécie é o principal fator que influencia nas propriedades do carvão. Através da análise das propriedades, não foi possível identificar qual espécie produziu o melhor carvão, uma vez que as três apresentaram algumas características consideradas boas, porém, sempre acompanhadas de outras inadequadas.

The timber industry in Amazonia generates large quantities of residues from log processing. A viable alternative for the enterprises is the production of charcoal from these residues. This study evaluates the main properties of the charcoal from Manilkara amazonica (maçaranduba), Lecythis pisonis (sapucaia) and Piptadenia suaveolens (timborana), carbonized in 7 and 10 days. The charcoal was produced from residues of timbers from the sawmill of Cikel Brasil Verde S. A., in Rio Capim estate, Paragominas, PA. A series of 30 kilns was used, being 10 for each species, of which 5 kilns used a 7-day carbonization process and 5 kilns 10 days. After the carbonization, samples of the charcoal produced were collected for studying gravimetric yield and physical, chemical and mechanical properties. The main results were: gravimetrical yield of the charcoal varied from 21,47 to 29,59 % (humid base); the bulk medium density varied from 178,51 to 231,14 kg.m-3; apparent medium density from 0,38 to 0,53 g.cm-3; calorific power from 23451 to 28830 kj.kg-1; volatile materials content from 23,94 to 31,47 %; ashes from 0,7 to 2,5 %; fixed carbon from 68,29 to 74,49 %; and the friableness varied from 12 to 32,6 %. It was noted that species is the main factor that influences the properties of the charcoal. It was not possible to say which species produced the best charcoal, from the properties analyses, because all the three species present some good characteristics, but these are always accompanied by other inadequate characteristics.

A síndrome da veia cava superior (SVCS) é condição relativamente rara. Relatamos o caso de um paciente de 42 anos, masculino, hipertenso há 15 anos, que evoluiu com dor cervical e torácica há um um ano, sendo evidenciada oclusão de 95% da coronária direita. Submetido a angioplastia, porém com persistência da dor torácica. Posteriormente evoluiu com episódios recorrentes de hemiplegia à direita associados a crises hipertensivas, que melhoravam com medicamentos anti-hipertensivos. Pela presença de coloração vinhosa na face e acentuação durante os períodos de ataques isquêmicos transitórios, foi feita a suspeita diagnóstica de provável acometimento do sistema de drenagem venosa, confirmada à venografia pelo achado de dilatação da veia jugular direita e imagem de estreitamento importante na junção com a veia cava superior. Em conclusão, não foi possível definir com certeza a relação entre as duas patologias no caso aqui apresentado, porém chamou a atenção a melhora dos sintomas neurológicos após o controle da SVCS com o tratamento instituído.

The superior vena cava obstruction is a relatively rare condition. We report the case of a 42 year old man suffering of hypertension for about fifteen years. He reported a cervical and thoracic pain for one year, that was related to a 95% of occlusion on the right coronary artery. An angioplasty has been done but the patient still related the thoracic pain. Afterwards the patient had recurrent episodes of right hemiplegia and hypertensive emergencies that have been treated with anti-hypertensive agents. A venous disease was suspected because of cyanosis in the face especially when episodes of transient ischemic attacks occurred. A venography showed obstruction of the right jugular vein near the junction with the superior vena cava. In conclusion, it was not possible to define with certainty the relationship between the two pathologies presented by the patient, even so, we call attention to the improvement of the neurological symptoms after the control of superior vena cava obstruction with the treatment.