BACKGROUND Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RDRio. The strain has been associated with different characteristics of the disease. OBJECTIVES In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RDRioMycobacterium tuberculosis strain in large regions of São Paulo. METHODS We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RDRio genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS The RDRio deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RDRio deletion. The multivariate analysis confirmed the association of the RDRio deletion with the age groups: 25-35 years old [OR: 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR: 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR: 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS In this study, we identified new factors associated with the M. tuberculosis of the RDRio deletion strains infection.

Paisagens são construídas, no duplo sentido de serem concebidas e de serem produtos da ação prática de sujeitos sobre o mundo. O artigo trata dos híbridos que emergem nas paisagens construídas por habitantes da zona rural de São Luiz do Paraitinga e por uma equipe de pesquisadores, da qual fiz parte, que estudava a região. A emergência de tais híbridos, num contexto considerado de crise por diversos agentes, em paisagens onde se presume uma divisão em espaços de produção e espaços de preservação, indica uma crise mais ampla da Modernidade, no sentido indicado por Latour, de que "jamais fomos modernos".

The present article deals with hybrids emerging in the landscapes built by the inhabitants of the rural zone of São Luiz do Paraitinga and a team of researchers studying the region, which I was part of. The appearance of these hybrids, considered to have taken place in a context of crisis, said so by several agents, and in landscapes where there is presumably a division of production and preservation sites, indicates a broad crisis of Modernity, in the sense of Latour that "we have never been modern".