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Evaluation of different hormone inducers on the reproduction of Prochilodus brevis males
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Vieira, Carla Tatiana Nascimento Sousa

; Sales, Yara Silvino

; Lobato, Jessica Sales

; Apoliano, Marcos Luiz da Silva

; Ferreira, Yasmim Maia

; Cândido-Sobrinho, Silvio Alencar

; Pereira, Vanessa Alves

; Salmito-Vanderley, Carminda Sandra Brito

Revista Ciência Agronômica

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2024, Volume 55 elocation e20228660

Abstract: En | Text: En | PDF: En

ABSTRACT The use of carp pituitary extract (CPE) in fish reproduction may have drawbacks, whereas analogues of mammalian (aGnRHm) or salmon (aGnRHs) gonadotropins containing dopamine inhibitor (DI) may offer greater advantages. The objective of this study was to evaluate the effect of different hormone inducers on the reproduction of Prochilodus brevis males. A total of 44 specimens of P. brevis were divided into six groups, namely, CPE 4.0 mg; saline solution 1.0 mL; aGnRHm + DI 0.3 mg and 0.5 mg; and aGnRHs + DI 0.25 mL and 0.35 mL kg-1 of live weight. The number of ejaculates, seminal volume, curvilinear velocity (VCL), straight-line velocity (VSL), average path velocity (VAP), sperm morphology and concentration, and membrane and DNA integrity were determined. Sample normality was examined using the Shapiro-Wilk test, and homogeneity using the Levene test. Analysis of variance (ANOVA) was conducted, followed by Tukey's test to compare means, with statistical significance set at p < 0.05. Notably, all fish induced with CPE 4.0 and aGnRHm + DI demonstrated ejaculation, yielding a greater seminal volume. Sperm concentration under aGnRHs + DI 0.35 exceeded that with aGnRHm + DI 0.3 and CPE 4.0. Regarding velocity, aGnRHm + DI 0.3 outperformed aGnRHs + DI 0.35 in VCL, while aGnRHm + DI 0.3 and 0.5 and aGnRHs + DI 0.25 led to higher VSL than aGnRHs 0.35. Additionally, VAP was elevated under aGnRHm + DI 0.3 and CPE, in contrast to aGnRHs + DI 0.35. Improved sperm morphology was observed with aGnRHm + DI 0.5 and aGnRHs + DI 0.25 compared to aGnRHm + DI 0.3. The remaining parameters did not differ significantly.

https://doi.org/10.5935/1806-6690.20240004

Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force
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Tavares, Anna Carolina Faria Moreira Gomes

; Melo, Ana Karla Guedes de

; Cruz, Vítor Alves

; Souza, Viviane Angelina de

; Carvalho, Joana Starling de

; Machado, Ketty Lysie Libardi Lira

; Valadares, Lilian David de Azevedo

; Reis Neto, Edgard Torres dos

; Rezende, Rodrigo Poubel Vieira de

; Guimarães, Maria Fernanda Brandão de Resende

; Ferreira, Gilda Aparecida

; Braz, Alessandra de Sousa

; Vieira, Rejane Maria Rodrigues de Abreu

; Pinheiro, Marcelo de Medeiros

; Ribeiro, Sandra Lúcia Euzébio

; Bica, Blanca Elena Gomes Rios

; Baptista, Kátia Lino

; Costa, Izaias Pereira da

; Marques, Claudia Diniz Lopes

; Lopes, Maria Lúcia Lemos

; Martinez, José Eduardo

; Giorgi, Rina Dalva Neubarth

; Mota, Lícia Maria Henrique da

; Loures, Marcos Antônio Araújo da Rocha

; Paiva, Eduardo dos Santos

; Monticielo, Odirlei André

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Pileggi, Gecilmara Cristina Salviato

Advances in Rheumatology

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2022, Volume 62 elocation 3

Abstract: En | Text: En | PDF: En

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

Influence of the ionic strength on the physicochemical properties of methotrexate-loaded chitosan polyelectrolyte complexes
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Agostini, Sandra Barbosa Neder

; Machado, Victor Lima de Sousa

; Virtuoso, Luciano Sindra

; Nogueira, Denismar Alves

; Pereira, Gislaine Ribeiro

; Carvalho, Flávia Chiva

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e20621

Abstract: En | Text: En | PDF: En

Abstract Polyelectrolyte complexes (PECs) as drug delivery systems are widely explored since they are easily obtained by coacervation and biopolymers can be associated. However, particle distribution is a challenging critical parameter that has been infrequently focused. This work evaluated the effect of NaCl concentration on the physicochemical properties of PECs based on chitosan and hypromellose loaded with methotrexate. The particle size, zeta potential and polydispersity index (PdI) were determined by DLS, besides of drug entrapment efficiency (EE) and in vitro drug release profile determination. Particle size decreased while NaCl concentration rised, achieving a narrower size distribution of (345±79 nm) and PdI (0.285±0.067) with 200 mmol/L NaCl. The higher the NaCl concentration, the lower the zeta potential at acid pH. The EE was kept similar ((28.2±4.5) %) from 0 to 300 mmol/L NaCl, while 400 mmol/L NaCl impaired the drug entrapment. The addition of (200 and 300) mmol/L NaCl did not affect the drug release profile, but it was faster with (100 or 400) mmol/L. In conclusion, the addition of 200 mmol/L NaCl reduced particle size and PdI with no changes in the EE and drug release. Therefore, the ionic strength plays an important role on PECs development.

https://doi.org/10.1590/s2175-97902022e20621

Management of hypoactive sexual desire disorder in women in the gynecological setting
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Lara, Lucia Alves da Silva

; Scalco, Sandra Cristina Poerner

; Rufino, Andréa Cronemberger

; Paula, Stany Rodrigues Campos de

; Fernandes, Eduardo Siqueira

; Pereira, Joice Martins de Lima

; França, Siglia Sousa de

; Reis, Sheila

; Almeida, Suzane Beirão de

; Vale, Fabiene Bernardes Castro

; Lerner, Théo

; Carvalho, Yara Maia Villar de

; Abdo, Carmita Helena Najjar

; Oliveira, Flávia Fairbanks Lima de

Revista Brasileira de Ginecologia e Obstetrícia

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may 2021, Volume 43 N. 5 Pages 417 - 423

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0041-1731410 98 downloads

Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology
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BRUCKI, Sonia Maria Dozzi

; ADONI, Tarso

; ALMEIDA, Carlos Mauricio Oliveira

; ANDRADE, Daniel Ciampi de

; ANGHINAH, Renato

; BARBOSA, Luciana Mendonça

; BAZAN, Rodrigo

; CARVALHO, Alzira Alves de Siqueira

; CARVALHO, William

; CHRISTO, Paulo Pereira

; COLETTA, Marcus Della

; CONFORTO, Adriana Bastos

; CORREA-NETO, Ylmar

; ENGELHARDT, Eliasz

; FRANÇA JUNIOR, Marcondes Cavalcante

; FRANCO, Clelia

; VON GLEHN, Felipe

; GOMES, Helio Rodrigues

; HOULY, Caroline Gomes de Barros

; KAUP, Alexandre Ottoni

; KOWACS, Fernando

; KANASHIRO, Aline

; LOPES, Victor Gonçalves

; MAIA, Débora

; MANREZA, Maria

; MARTINEZ, Alberto Rolim Muro

; MARTINEZ, Sandra Cristina Gonçalves

; NADER, Saulo Nardy

; NEVES, Luciana de Oliveira

; OKAMOTO, Ivan Hideyo

; OLIVEIRA, Rogério Adas Ayres de

; PEIXOTO, Fabiano de Melo

; PEREIRA, Cristiana Borges

; SABA, Roberta Arb

; SAMPAIO, Leticia Pereira de Brito

; SCHILLING, Lucas Porcello

; SILVA, Marcus Tulius Teixeira

; SILVA, Emanuelle Roberta

; SMID, Jerusa

; SOARES, Cristiane Nascimento

; SOBREIRA-NETO, Manoel

; SOUSA, Nise Alessandra de Carvalho

; SOUZA, Leonardo Cruz de

; TEIVE, Hélio Afonso Ghizoni

; TERRA, Vera Cristina

; VALE, Matheus

; VIEIRA, Vitor Mendes Grise

; ZANOTELI, Edmar

; PRADO, Gilmar

Arquivos de Neuro-Psiquiatria

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apr 2021, Volume 79 N. 4 Pages 354 - 369

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os canabinoides compreendem os endocanabinoides, fitocanabinoides e os canabinoides sintéticos e desempenham ações no sistema nervoso central e periférico. Uma quantidade enorme de publicações tem sido lançada nos últimos anos, embora a cannabis seja conhecida por milênios. Os Departamentos Científicos da Academia Brasileira de Neurologia descreveram as evidências do uso médico em suas áreas. A literatura está em constantes mudanças e possíveis novas evidências podem surgir nos próximos dias ou meses. A prescrição dessas substâncias deve ser discutida com os pacientes e suas famílias, com conhecimento sobre eventos adversos e sua eficácia.

ABSTRACT Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

https://doi.org/10.1590/0004-282x-anp-2020-0432 1049 downloads

Genotypic superiority of Psidium Guajava S1 families using mixed modeling for truncated and simultaneous selection
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Ambrósio, Moisés

; Viana, Alexandre Pio

; Ribeiro, Rodrigo Moreira

; Preisigke, Sandra Costa

; Cavalcante, Natan Ramos

; Silva, Flavia Alves da

; Torres, Géssica Xavier

; Sousa, Carlos Misael Bezerra de

Scientia Agricola

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2021, Volume 78 N. 2 elocation e20190179

Abstract: En | Text: En | PDF: En

ABSTRACT: The purpose of this study was to conduct selection, genetic parameter estimation, and prediction of genetic values for 18 S1 families of guava trees using mixed model methodology and simultaneous selection of traits by means of the additive selection index, multiplicative selection index, and mean rank adapted from Mulamba. All families analyzed were obtained by means of self-fertilization of superior genotypes (full siblings) from the genetic breeding program of guava trees at the Universidade Estadual do Norte Fluminense. An experimental randomized block design with 18 S1 families, three replicates, and ten plants per plot was used. A total of 540 genotypes (individual plants) of guava tree were evaluated. Genetic parameter estimation and selection of the best genotypes based on the genetic value were performed using the statistical procedure, from the Selegen-REML/BLUP program. The analyses of the additive selection index, multiplicative selection index, and the sum of rank adapted from Mulamba were also performed under the Selegen program. During the evaluation by the individual BLUPs, families 1, 12, 4, 6, and 8 contributed to most of the genotypes selected for the traits under evaluation, suggesting their significant potential to generate high quality and high yield genotypes. In the selection indexes via mixed models, the multiplicative index showed higher values for genetic gains (74 %), followed by the mean rank index adapted from Mulamba (19 %), and the additive index (2 %).

https://doi.org/10.1590/1678-992x-2019-0179 467 downloads

Effect of Metabolic Syndrome on Parkinson's Disease: A Systematic Review
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Souza, Ana Patrícia da Silva

; Barros, Waleska Maria Almeida

; Silva, José Maurício Lucas

; Silva, Mariluce Rodrigues Marques

; Silva, Ana Beatriz Januário

; Fernandes, Matheus Santos de Sousa

; Santos, Maria Eduarda Rodrigues Alves dos

; Silva, Mayara Luclécia da

; Carmo, Taciane Silva do

; Silva, Roberta Karlize Pereira

; Silva, Karollainy Gomes da

; Souza, Sandra Lopes de

; Souza, Viviane de Oliveira Nogueira

Clinics

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2021, Volume 76 elocation e3379

Abstract: En | Text: En | PDF: En

Evidence shows that metabolic syndrome (MS) is associated with a greater risk of developing Parkinson's disease (PD) because of the increase in oxidative stress levels along with other factors such as neuroinflammation and mitochondrial dysfunction. However, because some studies have reported that MS is associated with a lower risk of PD, the relationship between MS and PD should be investigated. This study aimed to investigate the effect of MS on PD. Two authors searched five electronic databases, namely, MEDLINE, PubMed, Scopus, PsycINFO, Web of Science, and Science Direct, for relevant articles between September and October 2020. After screening the title and abstract of all articles, 34 articles were selected for full-text review. Finally, 11 articles meeting the eligibility criteria were included in the study. The quality of articles was critically evaluated using the Joanna Briggs Institute. Overall, we evaluated data from 23,586,349 individuals (including healthy individuals, with MS and PD) aged 30 years or more. In cohort studies, the follow-up period varied between 2 and 30 years. MS contributed considerably to the increase in the incidence of PD. In addition, obesity, a component of MS, alone can increase the probability of developing neurodegenerative diseases. However, despite few studies on MS and PD, changes in cognitive function and more rapid progression of PD disease has been documented in patients with MS using methods commonly used in research.

https://doi.org/10.6061/clinics/2021/e3379

A RESPONSABILIDADE CIVIL E A RECORRENTE VIOLAÇÃO AOS DIREITOS DE PERSONALIDADE E AO MEIO AMBIENTE POR GRANDES CORPORAÇÕES
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Sousa, Angela Alves de

; Sette, Sandra Mara Franco

; Reis, Clayton

Revista Internacional CONSINTER de Direito - Publicação Oficial do Conselho Internacional de Estudos Contemporâneos em Pós-Graduação

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dec 2020, N. 11 Pages 605 - 620

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Em tempos de incertezas e mudanças constantes, a questão dos danos punitivos por lesão aos direitos de personalidade e ao meio ambiente, praticados por grandes corporações, conduz a uma necessidade de repensar os institutos, integrando o ordenamento jurídico pátrio em um contexto global. A presente pesquisa inseriu na investigação as questões inerentes aos direitos de personalidade e direitos humanos, bem como, os institutos da responsabilidade civil e a autonomia da pena civil perante o instituto de danos morais e seus desdobramentos, face à sociedade do século XXI. Neste contexto, buscou-se compreender o direito e seus possíveis novos papéis, em especial no ordenamento jurídico pátrio, apontando alterações necessárias à sua evolução com a finalidade de coibir a reincidência de condutas lesivas por parte das grandes corporações.

Abstract In times of uncertainty and constant changes, the matter of the punitive damages for injury to the personality rights and environment, caused by great corporations, leads to a necessity of representing the institutes, integrating the national legal system in a international context. The presente research insert in the ivertigation the matters inherent to the personality rights and human rights, as well as, the institutes of the civil responsability and the autonomy of the civil penalty before the institute of the moral damage and it's unfoldings, in face of the XXI century society. In this context, sought to comprehend the Law and it's possible new roles, in special in the national legal system, pointing necessary alterations to it's evolution with the finalty of restraining the recurrence of harmful conduct by the great corporations.

https://doi.org/10.19135/revista.consinter.00011.29 42 downloads

DANOS MORAIS: O INGRESSO DA PENA CIVIL NO SISTEMA DE DIREITO PRIVADO BRASILEIRO
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Séllos-Knoerr, Viviane Coêlho de

; Sette, Sandra Mara Franco

; Sousa, Angela Alves de

Revista Internacional CONSINTER de Direito - Publicação Oficial do Conselho Internacional de Estudos Contemporâneos em Pós-Graduação

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jun 2020, N. 10 Pages 463 - 476

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A tão decantada impunidade atrelada à violação ao que é proposto na Declaração Universal dos Direitos Humanos, em especial a conduta praticada por empresas transnacionais, as quais se instalam em países em desenvolvimento, foram uma fonte inspiradora para o presente trabalho. O foco principal deste trabalho foi o estudo do Ordenamento Jurídico Brasileiro e a possibilidade de preencher lacunas encontradas no Instituto da Responsabilidade Civil, e, nele, as questões referentes ao dano moral através da aplicação da pena civil. O Instituto do “Punitive Damages”, utilizado no ordenamento jurídico de países do “Common Law”, a nosso ver, é um mecanismo que, se implementado no Brasil, pode contribuir para atender a necessidade de evitar o delito, atuando preventivamente enquanto punindo eventuais transgressores. Neste contexto, a presente investigação conduzirá a algumas análises acerca da aplicação da pena civil aos danos morais no sistema de direito privado e público. Serão avaliados o dolo, a culpa, assim como pena civil e sua autonomia, bem como seus critérios de aplicabilidade. Tem como objetivo geral refletir e colocar questões inerentes à contemporaneidade, situando o ordenamento jurídico pátrio num aspecto amplo, inserido em um contexto global e nas particularidades dessa nova sociedade. A pesquisa iniciar-se-á com levantamento bibliográfico, não apenas da doutrina e seus derivados, mas inclusive em artigos e obras da área do Direito, Sociologia, Antropologia e História da Economia. Adotar-se-á o método dedutivo/indutivo, sendo este o meio mais adequado ao desenvolvimento do presente trabalho, em razão das diversas interpretações e discussões sob os mais diversos aspectos que o tema acarreta.

Abstract The so decanted impunity attached to the violation of what is proposed in the Universal Declaration of Human Rights, in special the conduct practiced by transnational companies, which settle in developing countries, were an inspirational source for the present work. The main focus of this work was the study of the Brazilian Legal System and the possibility of filling gaps found in the Institute of Civil Responsability, and, in it, the matters reffering to moral damage through the applicaton of the civil penalty. The Institute of Punitive Damages used in the legal system of countries of the “Common Law”, in our view, is a mechanism that, if implemented in Brazil, can contribute to attend the necessity of averting the delict, acting preentively while punishing eventual transgressores. The so decanted impunity linked to violation of what is proposed by the Universal Declaration of Human Rights, especially the practiced conduct by transnational corporations, which set up themselves in developing countries, was an inspiring source for the present work. The main focus of this work was the study of the Brazilian Legal System and the possibility of filling gaps found in the Institute of Civil Liability, and in it, the matters related to moral damage caused by the application of the civil penalty. The Institute of “Punitive Damage”, used in the legal system of “Common Law” countries, as we see it, is a mechanism that if implemented in Brazil can contribute to addressing the need to prevent crime by acting preventively while punishing eventual transgressors. In this context, the present investigation will conduct some analyzes on the application of the civil penalty to moral damages in the system of private and public law. It will be evaluated the damage, the guilt, as well as the civil penalty and its autonomy, as well as their application requirements. Have as general objective to reflect and pose questions inherent to contemporaneity, situating the homeland legal system on a broad aspect, inserted in a global context and the particularities of this new society. The research will begin with a bibliographic survey, not only of the doctrine and its derivatives but even in articles and works in the area of Law, Sociology, Anthropology, and History of Economics. The deductive/inductive method will be adopted, this being the most appropriate means for the development of the present work, due to various interpretations and discussions under the most diverse aspects of the theme.

https://doi.org/10.19135/revista.consinter.00010.23 30 downloads

10.

Physical and chemical characterization of sewage sludge with different proportions of diatomaceous earth
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Braga, Fabíola Mendes

; Barbosa, Mário Henrique Cardoso

; Oliveira, Ely Sandra Alves

; Sousa, Izabelle de Paula

; Santos, Claudiana Barbosa dos

; Sampaio, Regynaldo Arruda

Revista Ceres

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feb 2020, Volume 67 N. 1 Pages 81 - 85

Abstract: En | Text: En | PDF: En

ABSTRACT The use of residues for agricultural production is an alternative for the achievement of sustainability. When mixed with diatomaceous earth (DE) from biofuel filtration, sewage sludge (SS) plays an important role as soil conditioning agent. As a result, the objective of this work was to make a DE vermicompost at different proportions: 0; 7.53; 15.06; 22.59 and 30.12% v/v in relation to a SS pre-compost (PC) and gardening pruning residues. The experiment was carried out in 100-L containers in a randomized block design, with 5 treatments and 5 replications, in which Eisenia foetida earthworms were used in the pre-composting and vermicomposting processes. After four months, the physical characteristics of the vermicompost were analyzed. It was verified that the diatomaceous earth can be vermicomposted, even when soaked in biofuel oil, at amounts of up to 30.12% v/v, with no visible physical damage to earthworms and plants, and this proportion of DE reduced the concentration of nutrients, but improved the physical properties of the vermicompost, making it an excellent physical conditioner for use as a substrate of plants and fertilization of soils.

https://doi.org/10.1590/0034-737x202067010011 801 downloads

11.

Investigation of wound healing activity of Lafoensia pacari (Lythraceae) leaves extract cultivated in Goiás state, Brazil
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Chaibub, Beatriz Abdallah

; Parente, Leila Maria Leal

; Lino Jr, Ruy de Souza

; Cirilo, Herica Nubia Cardoso

; Garcia, Sandra Alves de Sousa

; Nogueira, João Carlos Mohn

; Conceição, Edemilson Cardodo da

; Thomaz, Douglas Vieira

; Santos, Suzana da Costa

; Bara, Maria Teresa Freitas

Rodriguésia

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2020, Volume 71 elocation e00992019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Lafoensia pacari é empregada na medicina tradicional no cerrado Brasileiro para tratar feridas. É importante desenvolver estudos para melhor compreender como ocorre a atividade biológica de L. pacari . O objetivo deste estudo foi avaliar a atividade cicatrizante do extrato das folhas de L. pacari em modelo animal. O extrato vegetal foi preparado a partir de plantas oriundas de Goiânia-GO, Brasil. Na avaliação da atividade cicatrizante, foi empregado o modelo de feridas cutâneas em ratos. Análise macroscópica, morfométrica e histológica das feridas também foram realizadas. Na cromatografia de camada delgada foi detectada a presença de taninos hidrolisáveis e na cromatografia líquida de alta eficiência, pôde-se sugerir a presença de elagitaninos. Na avaliação das feridas cutâneas em ratos foi possível observar que o tratamento com extrato de L. pacari a 10% (m/v) proporcionou uma redução no tempo de cicatrização de feridas cutâneas em ratos, com aumento significativo das variáveis envolvidas na cicatrização, como número de vasos sanguíneos e a produção de colágeno. Portanto, este estudo mostra que o potencial cicatrizante de L. pacari pode estar relacionado à presença de elagitaninos, o que corrobora com relatos etnofarmacológicos deste vegetal.

Abstract Lafoensia pacari has been used in traditional folk medicine in Brazilian Cerrado to treat wounds. It is important to develop studies that can clarify how the biological activity of L. pacari occurs. The aim of this study was to evaluate the healing activity of L. pacari leaves extract in an animal model. The extract was prepared from plants cultivated in Goiania-GO, Brazil. The healing activity was assayed using cutaneous wound model in rats, and macroscopic, morphometric and histological analysis of wounds were also conducted. The presence of hydrolysable tannins was detected in thin layer chromatography and in high performance liquid chromatography analysis, may be suggested the presence of ellagitannins. In the evaluation of cutaneous wounds in rats it was possible to observe that the treatment with 10% (w/v) L. pacari extract provided a reduction in the time of cutaneous wound healing, with a significant increase in variables involved in healing, such as the number of blood vessels and collagen production. Therefore, this study shows that L. pacari wound healing potential may be related to the presence of ellagitannins and corroborates to ethnopharmacological reports regarding this plant.

https://doi.org/10.1590/2175-7860202071058 634 downloads

12.

Recommendations of the Brazilian Society of Rheumatology for the diagnosis and treatment of chikungunya fever. Part 2 - Treatment
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Marques, Claudia Diniz Lopes

; Duarte, Angela Luzia Branco Pinto

; Ranzolin, Aline

; Dantas, Andrea Tavares

; Cavalcanti, Nara Gualberto

; Gonçalves, Rafaela Silva Guimarães

; Rocha Junior, Laurindo Ferreira da

; Valadares, Lilian David de Azevedo

; Melo, Ana Karla Guedes de

; Freire, Eutilia Andrade Medeiros

; Teixeira, Roberto

; Neto, Francisco Alves Bezerra

; Medeiros, Marta Maria das Chagas

; Carvalho, Jozélio Freire de

; Santos, Mario Sergio F.

; Océa, Regina Adalva de L. Couto

; Levy, Roger A.

; Andrade, Carlos Augusto Ferreira de

; Pinheiro, Geraldo da Rocha Castelar

; Abreu, Mirhelen Mendes

; Verztman, José Fernando

; Merenlender, Selma

; Ribeiro, Sandra Lucia Euzebio

; Costa, Izaias Pereira da

; Pileggi, Gecilmara

; Trevisani, Virginia Fernandes Moça

; Lopes, Max Igor Banks

; Brito, Carlos

; Figueiredo, Eduardo

; Queiroga, Fabio

; Feitosa, Tiago

; Tenório, Angélica da Silva

; Siqueira, Gisela Rocha de

; Paiva, Renata

; Vasconcelos, José Tupinambá Sousa

; Christopoulos, Georges

Revista Brasileira de Reumatologia

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2017, Volume 57 Suppl. 2 Pages s438 - s451

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A febre chikungunya tem se tornado um importante problema de saúde pública nos países onde ocorrem as epidemias, visto que metade dos casos evolui com artrite crônica, persistente e incapacitante. Os dados na literatura sobre terapêuticas específicas nas diversas fases da artropatia ocasionada pela infecção pelo vírus chikungunya (CHIKV) são limitados, não existem estudos randomizados de qualidade que avaliem a eficácia das diferentes terapias. Há algumas poucas publicações sobre o tratamento das manifestações musculoesqueléticas da febre chikungunya, porém com importantes limitações metodológicas. Os dados atualmente disponíveis não permitem conclusões favoráveis ou contrárias a terapêuticas específicas, bem como uma adequada avaliação quanto à superioridade entre as diferentes medicações empregadas. O objetivo deste trabalho foi elaborar recomendações para o tratamento da febre chikungunya no Brasil. Foi feita uma revisão da literatura com seleção de artigos baseados em evidência, nas bases de dados Medline, SciELO, PubMed e Embase e de resumos de anais de congressos, além da opinião dos especialistas para dar apoio às decisões tomadas para definir as recomendações. Para a definição do grau de concordância foi feita uma metodologia Delphi, em duas reuniões presenciais e várias rodadas de votação on line. Este artigo refere-se à parte 2 das Recomendações da Sociedade Brasileira de Reumatologia para Diagnóstico e Tratamento da Febre Chikungunya, que trata especificamente do tratamento.

Abstract Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations. The data currently available preclude conclusions favorable or contrary to specific therapies, or an adequate comparison between the different drugs used. The objective of this study was to develop recommendations for the treatment of chikungunya fever in Brazil. A literature review was performed via evidence-based selection of articles in the databases Medline, SciELO, PubMed and Embase and conference proceedings abstracts, in addition to expert opinions to support decision-making in defining recommendations. The Delphi method was used to define the degrees of agreement in 2 face-to-face meetings and several online voting rounds. This study is part 2 of the Recommendations of the Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia - SBR) for the Diagnosis and Treatment of chikungunya fever and specifically addresses treatment.

https://doi.org/10.1016/j.rbre.2017.06.004 38509 downloads

13.

Recommendations of the Brazilian Society of Rheumatology for diagnosis and treatment of Chikungunya fever. Part 1 - Diagnosis and special situations
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Marques, Claudia Diniz Lopes

; Duarte, Angela Luzia Branco Pinto

; Ranzolin, Aline

; Dantas, Andrea Tavares

; Cavalcanti, Nara Gualberto

; Gonçalves, Rafaela Silva Guimarães

; Rocha Junior, Laurindo Ferreira da

; Valadares, Lilian David de Azevedo

; Melo, Ana Karla Guedes de

; Freire, Eutilia Andrade Medeiros

; Teixeira, Roberto

; Bezerra Neto, Francisco Alves

; Medeiros, Marta Maria das Chagas

; Carvalho, Jozélio Freire de

; Santos, Mario Sergio F.

; Océa, Regina Adalva de L. Couto

; Levy, Roger A.

; Andrade, Carlos Augusto Ferreira de

; Pinheiro, Geraldo da Rocha Castelar

; Abreu, Mirhelen Mendes

; Verztman, José Fernando

; Merenlender, Selma

; Ribeiro, Sandra Lucia Euzebio

; Costa, Izaias Pereira da

; Pileggi, Gecilmara

; Trevisani, Virginia Fernandes Moça

; Lopes, Max Igor Banks

; Brito, Carlos

; Figueiredo, Eduardo

; Queiroga, Fabio

; Feitosa, Tiago

; Tenório, Angélica da Silva

; Siqueira, Gisela Rocha de

; Paiva, Renata

; Vasconcelos, José Tupinambá Sousa

; Christopoulos, Georges

Revista Brasileira de Reumatologia

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2017, Volume 57 Suppl. 2 Pages s421 - s437

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A febre chikungunya tem se tornado um importante problema de saúde pública nos países onde ocorrem as epidemias. Até 2013, as Américas haviam registrado apenas casos importados quando, em outubro desse mesmo ano, foram notificados os primeiros casos na Ilha de Saint Martin, no Caribe. No Brasil, os primeiros relatos autóctones foram confirmados em setembro de 2014 e até a semana epidemiológica 37 de 2016 já haviam sido registrados 236.287 casos prováveis de infecção pelo chikungunya vírus (CHIKV), 116.523 confirmados sorologicamente. As mudanças ambientais causadas pelo homem, o crescimento urbano desordenado e o número cada vez maior de viagens internacionais têm sido apontados como os fatores responsáveis pela reemergência de epidemias em grande escala. Caracterizada clinicamente por febre e dor articular na fase aguda, em cerca de metade dos casos existe evolução para a fase crônica (além de três meses), com dor persistente e incapacitante. O objetivo deste trabalho foi elaborar recomendações para diagnóstico e tratamento da febre chikungunya no Brasil. Para isso, foi feita revisão da literatura nas bases de dados Medline, SciELO e PubMed, para dar apoio às decisões tomadas para definir as recomendações. Para a definição do grau de concordância foi feita uma metodologia Delphi, em duas reuniões presenciais e várias rodadas de votação on line. Foram geradas 25 recomendações, divididas em três grupos temáticos: (1) diagnóstico clínico, laboratorial e por imagem; (2) situações especiais e (3) tratamento. Na primeira parte estão os dois primeiros temas e o tratamento na segunda.

Abstract Chikungunya fever has become a relevant public health problem in countries where epidemics occur. Until 2013, only imported cases occurred in the Americas, but in October of that year, the first cases were reported in Saint Marin island in the Caribbean. The first autochthonous cases were confirmed in Brazil in September 2014; until epidemiological week 37 of 2016, 236,287 probable cases of infection with Chikungunya virus had been registered, 116,523 of which had serological confirmation. Environmental changes caused by humans, disorderly urban growth and an ever-increasing number of international travelers were described as the factors responsible for the emergence of large-scale epidemics. Clinically characterized by fever and joint pain in the acute stage, approximately half of patients progress to the chronic stage (beyond 3 months), which is accompanied by persistent and disabling pain. The aim of the present study was to formulate recommendations for the diagnosis and treatment of Chikungunya fever in Brazil. A literature review was performed in the MEDLINE, SciELO and PubMed databases to ground the decisions for recommendations. The degree of concordance among experts was established through the Delphi method, involving 2 in-person meetings and several online voting rounds. In total, 25 recommendations were formulated and divided into 3 thematic groups: (1) clinical, laboratory and imaging diagnosis; (2) special situations; and (3) treatment. The first 2 themes are presented in part 1, and treatment is presented in part 2.

https://doi.org/10.1016/j.rbre.2017.05.006 37996 downloads

14.

Implementación del análisis de la situación de salud en una unidad básica sanitaria de Brasil
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Zayas Vinent, Meinardo

; Alves Correia, Alessandra

; Barbosa de Sousa Lopes, Sandra Rogeria

; Aparecida Magalhaes, Cristiana

MEDISAN

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oct 2016, Volume 20 N. 10 Pages 2240 - 2249

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

An observational, descriptive and cross-sectional study of 618 families with 1 943 inhabitants, belonging to the Health Basic Unit No. 1, São Vicente, of the Vianópolis municipality, in the Goiás state, Brazil, during the months of May to July, 2015, with the objective of carrying out the analysis of the health situation of 2014, for which the methodology of the Mato Grosso of the South University was used. Data were collected in the Statistical Department from the Health Secretary, and through surveys applied to the health community agents and the population, and formal and informal interviews made to different social actors. The main problems were the high incidences of hypertension, diabetes mellitus, alcoholism and pregnant adolescents, as well as the little knowledge of hypertensive people on their disease and the bad dietary and social habits

Se efectuó un estudio observacional, descriptivo y transversal de 618 familias con 1 943 habitantes, pertenecientes a la Unidad Básica de Salud No. 1 São Vicente, del municipio de Vianópolis, en el estado Goiás, Brasil, durante los meses de mayo a julio del 2015, con vistas a realizar el análisis de la situación de salud del año 2014, para lo cual se utilizó la metodología de la Universidad de Mato Grosso del Sur. Los datos fueron recolectados en el Departamento de Estadísticas de la Secretaría de Salud, y a través de encuestas aplicadas a los agentes comunitarios de salud y a la población, y entrevistas efectuadas a diferentes actores sociales formales e informales. Los principales problemas fueron las altas incidencias de hipertensión arterial, diabetes mellitus, alcoholismo y adolescentes gestantes, así como el poco conocimiento de las personas hipertensas sobre su enfermedad y los malos hábitos dietéticos y sociales

15.

Documentação do processo de enfermagem: justificativa e métodos de estudo analítico
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Cruz, Diná de Almeida Lopes Monteiro da

; Guedes, Erika de Souza

; Santos, Mariana Alvina dos

; Sousa, Regina Márcia Cardoso de

; Turrini, Ruth Natalia Teresa

; Maia, Magda Maria

; Araújo, Sandra Alves Neves

Revista Brasileira de Enfermagem

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feb 2016, Volume 69 N. 1 Pages 197 - 204

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to describe the methods used to analyze the associations between variables of service, nursing and the nursing process documentation in institutions of the Department of Health of the State of São Paulo. Method: multilevel analytical study with data obtained in the domains of institution, units of the institution and nursing professionals who work there, using standardized instruments. The analyses had as axis the degree of completeness of the nursing process documentation in units or institutions and their association with variables of nursing personnel, of units and of institutions. Conclusion: This study will provide important empirical evidence on the factors involved in the nursing process documentation.

RESUMEN Objetivo: describir los métodos usados para analizar las asociaciones entre variables del servicio, de la enfermería y de la documentación del proceso de enfermería en las instituciones de la Secretaria de Estado de la Salud de São Paulo. Método: estudio analítico multi-nivel, con datos obtenidos en los ámbitos de la institución, de los sectores de la institución y de los profesionales de enfermería que en ellos actúan, por medio de instrumentos empadronados. Los análisis tuvieron como eje el grado de la documentación completa del proceso de enfermería en los sectores o en las instituciones y sus asociaciones con variables del personal de enfermería, de las unidades y de las instituciones. Conclusión: este estudio empírico fornecerá importantes evidencias sobre los factores envueltos en la documentación del proceso de enfermería.

RESUMO Objetivo: descrever os métodos usados para analisar as associações entre variáveis do serviço, da enfermagem e da documentação do processo de enfermagem nas instituições da Secretaria de Estado da Saúde de São Paulo. Método: estudo analítico multinível, com dados obtidos nos âmbitos da instituição, dos setores da instituição e dos profissionais de enfermagem que neles atuam, por meio de instrumentos padronizados. As análises tiveram como eixo o grau de completude da documentação do processo de enfermagem nos setores ou nas instituições e suas associações com variáveis do pessoal de enfermagem, das unidades e das instituições. Conclusão: este estudo empírico fornecerá importantes evidências sobre os fatores envolvidos na documentação do processo de enfermagem. Descritores: Processos de Enfermagem; Pesquisa Metodológica em Enfermagem; Pesquisa em Enfermagem.

https://doi.org/10.1590/0034-7167.2016690126i 2 downloads

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